Amino acid dipepetide frequency for Streptococcus satellite phage Javan749

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.0AlaAla: 0.0 ± 0.0
0.334AlaCys: 0.334 ± 0.336
2.007AlaAsp: 2.007 ± 1.117
3.344AlaGlu: 3.344 ± 0.923
2.676AlaPhe: 2.676 ± 0.999
2.341AlaGly: 2.341 ± 0.692
0.669AlaHis: 0.669 ± 0.505
3.01AlaIle: 3.01 ± 0.995
7.023AlaLys: 7.023 ± 1.698
4.348AlaLeu: 4.348 ± 1.044
2.007AlaMet: 2.007 ± 0.818
2.341AlaAsn: 2.341 ± 0.738
0.334AlaPro: 0.334 ± 0.28
3.01AlaGln: 3.01 ± 0.962
3.344AlaArg: 3.344 ± 1.074
2.007AlaSer: 2.007 ± 0.888
4.013AlaThr: 4.013 ± 1.35
3.344AlaVal: 3.344 ± 0.983
0.0AlaTrp: 0.0 ± 0.0
3.01AlaTyr: 3.01 ± 0.791
0.0AlaXaa: 0.0 ± 0.0
Cys
1.003CysAla: 1.003 ± 0.516
0.0CysCys: 0.0 ± 0.0
0.334CysAsp: 0.334 ± 0.374
0.334CysGlu: 0.334 ± 0.27
0.334CysPhe: 0.334 ± 0.286
0.334CysGly: 0.334 ± 0.304
0.334CysHis: 0.334 ± 0.27
0.669CysIle: 0.669 ± 0.434
0.669CysLys: 0.669 ± 0.502
1.003CysLeu: 1.003 ± 0.474
0.0CysMet: 0.0 ± 0.0
0.334CysAsn: 0.334 ± 0.314
1.003CysPro: 1.003 ± 0.447
1.338CysGln: 1.338 ± 0.985
0.0CysArg: 0.0 ± 0.0
0.334CysSer: 0.334 ± 0.336
0.334CysThr: 0.334 ± 0.376
0.669CysVal: 0.669 ± 0.449
0.0CysTrp: 0.0 ± 0.0
0.334CysTyr: 0.334 ± 0.305
0.0CysXaa: 0.0 ± 0.0
Asp
1.003AspAla: 1.003 ± 0.403
1.003AspCys: 1.003 ± 0.404
5.686AspAsp: 5.686 ± 1.246
2.676AspGlu: 2.676 ± 0.984
5.017AspPhe: 5.017 ± 0.934
3.01AspGly: 3.01 ± 0.994
0.0AspHis: 0.0 ± 0.0
7.023AspIle: 7.023 ± 1.207
6.355AspLys: 6.355 ± 1.889
7.358AspLeu: 7.358 ± 1.592
1.338AspMet: 1.338 ± 0.719
6.02AspAsn: 6.02 ± 0.884
1.338AspPro: 1.338 ± 0.542
0.669AspGln: 0.669 ± 0.472
2.676AspArg: 2.676 ± 0.872
3.679AspSer: 3.679 ± 1.78
2.341AspThr: 2.341 ± 0.854
2.341AspVal: 2.341 ± 0.637
0.669AspTrp: 0.669 ± 0.398
3.01AspTyr: 3.01 ± 1.394
0.0AspXaa: 0.0 ± 0.0
Glu
2.341GluAla: 2.341 ± 1.162
1.338GluCys: 1.338 ± 0.556
3.679GluAsp: 3.679 ± 1.245
3.679GluGlu: 3.679 ± 1.014
3.344GluPhe: 3.344 ± 1.176
2.007GluGly: 2.007 ± 1.037
1.003GluHis: 1.003 ± 0.524
8.696GluIle: 8.696 ± 1.12
9.03GluLys: 9.03 ± 1.727
9.03GluLeu: 9.03 ± 1.817
2.341GluMet: 2.341 ± 0.764
5.017GluAsn: 5.017 ± 1.345
1.338GluPro: 1.338 ± 0.608
3.679GluGln: 3.679 ± 1.065
2.341GluArg: 2.341 ± 0.836
7.023GluSer: 7.023 ± 1.75
4.013GluThr: 4.013 ± 0.876
4.013GluVal: 4.013 ± 1.43
0.669GluTrp: 0.669 ± 0.434
4.013GluTyr: 4.013 ± 1.166
0.0GluXaa: 0.0 ± 0.0
Phe
1.338PheAla: 1.338 ± 0.777
0.669PheCys: 0.669 ± 0.627
3.679PheAsp: 3.679 ± 1.155
3.01PheGlu: 3.01 ± 1.532
2.341PhePhe: 2.341 ± 0.806
1.338PheGly: 1.338 ± 0.547
0.334PheHis: 0.334 ± 0.27
3.344PheIle: 3.344 ± 1.041
4.682PheLys: 4.682 ± 1.427
4.348PheLeu: 4.348 ± 1.333
0.669PheMet: 0.669 ± 0.471
3.01PheAsn: 3.01 ± 1.066
1.338PhePro: 1.338 ± 0.781
1.672PheGln: 1.672 ± 0.757
1.672PheArg: 1.672 ± 0.692
2.341PheSer: 2.341 ± 0.845
2.007PheThr: 2.007 ± 0.793
1.338PheVal: 1.338 ± 1.003
0.334PheTrp: 0.334 ± 0.304
1.672PheTyr: 1.672 ± 0.821
0.0PheXaa: 0.0 ± 0.0
Gly
3.01GlyAla: 3.01 ± 0.893
0.334GlyCys: 0.334 ± 0.313
1.003GlyAsp: 1.003 ± 0.61
4.013GlyGlu: 4.013 ± 1.061
0.669GlyPhe: 0.669 ± 0.437
1.338GlyGly: 1.338 ± 0.619
1.338GlyHis: 1.338 ± 0.678
2.676GlyIle: 2.676 ± 0.707
4.013GlyLys: 4.013 ± 1.046
3.344GlyLeu: 3.344 ± 0.772
1.338GlyMet: 1.338 ± 0.635
2.341GlyAsn: 2.341 ± 1.022
0.0GlyPro: 0.0 ± 0.0
2.007GlyGln: 2.007 ± 0.728
1.338GlyArg: 1.338 ± 0.728
2.676GlySer: 2.676 ± 1.045
3.01GlyThr: 3.01 ± 0.876
2.341GlyVal: 2.341 ± 0.874
0.334GlyTrp: 0.334 ± 0.314
4.013GlyTyr: 4.013 ± 1.32
0.0GlyXaa: 0.0 ± 0.0
His
2.007HisAla: 2.007 ± 0.887
0.0HisCys: 0.0 ± 0.0
0.669HisAsp: 0.669 ± 0.435
0.669HisGlu: 0.669 ± 0.505
0.0HisPhe: 0.0 ± 0.0
0.334HisGly: 0.334 ± 0.374
0.334HisHis: 0.334 ± 0.313
0.669HisIle: 0.669 ± 0.545
0.0HisLys: 0.0 ± 0.0
3.01HisLeu: 3.01 ± 1.051
0.0HisMet: 0.0 ± 0.0
1.003HisAsn: 1.003 ± 0.708
0.669HisPro: 0.669 ± 0.422
0.669HisGln: 0.669 ± 0.449
1.338HisArg: 1.338 ± 0.67
0.669HisSer: 0.669 ± 0.705
1.338HisThr: 1.338 ± 0.576
0.334HisVal: 0.334 ± 0.34
0.0HisTrp: 0.0 ± 0.0
0.334HisTyr: 0.334 ± 0.305
0.0HisXaa: 0.0 ± 0.0
Ile
2.676IleAla: 2.676 ± 0.93
0.0IleCys: 0.0 ± 0.0
6.02IleAsp: 6.02 ± 1.251
6.02IleGlu: 6.02 ± 1.793
3.344IlePhe: 3.344 ± 1.129
2.007IleGly: 2.007 ± 0.844
1.338IleHis: 1.338 ± 0.691
4.682IleIle: 4.682 ± 1.19
10.033IleLys: 10.033 ± 1.706
7.358IleLeu: 7.358 ± 1.606
2.007IleMet: 2.007 ± 0.692
3.679IleAsn: 3.679 ± 0.918
3.679IlePro: 3.679 ± 0.866
3.679IleGln: 3.679 ± 0.734
2.676IleArg: 2.676 ± 0.729
5.351IleSer: 5.351 ± 1.22
3.01IleThr: 3.01 ± 0.783
2.676IleVal: 2.676 ± 0.865
0.334IleTrp: 0.334 ± 0.374
3.01IleTyr: 3.01 ± 0.979
0.0IleXaa: 0.0 ± 0.0
Lys
7.358LysAla: 7.358 ± 1.299
1.338LysCys: 1.338 ± 0.59
6.355LysAsp: 6.355 ± 1.688
10.368LysGlu: 10.368 ± 1.753
3.01LysPhe: 3.01 ± 1.043
5.017LysGly: 5.017 ± 1.15
2.007LysHis: 2.007 ± 0.938
6.355LysIle: 6.355 ± 1.156
8.027LysLys: 8.027 ± 1.148
11.037LysLeu: 11.037 ± 1.763
1.672LysMet: 1.672 ± 0.763
7.692LysAsn: 7.692 ± 1.491
2.341LysPro: 2.341 ± 1.041
4.013LysGln: 4.013 ± 0.796
5.351LysArg: 5.351 ± 1.194
8.696LysSer: 8.696 ± 1.307
7.023LysThr: 7.023 ± 1.39
3.679LysVal: 3.679 ± 0.913
1.003LysTrp: 1.003 ± 0.567
4.682LysTyr: 4.682 ± 1.06
0.0LysXaa: 0.0 ± 0.0
Leu
7.023LeuAla: 7.023 ± 1.438
1.003LeuCys: 1.003 ± 0.606
10.033LeuAsp: 10.033 ± 1.636
9.699LeuGlu: 9.699 ± 0.973
3.679LeuPhe: 3.679 ± 1.026
4.348LeuGly: 4.348 ± 0.972
0.334LeuHis: 0.334 ± 0.313
7.692LeuIle: 7.692 ± 1.247
9.699LeuLys: 9.699 ± 1.556
7.692LeuLeu: 7.692 ± 1.525
2.676LeuMet: 2.676 ± 0.599
8.361LeuAsn: 8.361 ± 1.495
2.676LeuPro: 2.676 ± 0.843
5.017LeuGln: 5.017 ± 1.11
4.682LeuArg: 4.682 ± 0.781
4.682LeuSer: 4.682 ± 0.901
8.027LeuThr: 8.027 ± 1.566
3.344LeuVal: 3.344 ± 0.817
0.0LeuTrp: 0.0 ± 0.0
2.676LeuTyr: 2.676 ± 0.869
0.0LeuXaa: 0.0 ± 0.0
Met
2.341MetAla: 2.341 ± 0.992
0.334MetCys: 0.334 ± 0.376
1.672MetAsp: 1.672 ± 0.711
2.007MetGlu: 2.007 ± 0.731
0.669MetPhe: 0.669 ± 0.52
0.334MetGly: 0.334 ± 0.376
0.0MetHis: 0.0 ± 0.0
1.338MetIle: 1.338 ± 0.56
2.676MetLys: 2.676 ± 0.619
1.338MetLeu: 1.338 ± 0.447
0.334MetMet: 0.334 ± 0.343
1.338MetAsn: 1.338 ± 0.64
1.003MetPro: 1.003 ± 0.541
0.334MetGln: 0.334 ± 0.28
2.341MetArg: 2.341 ± 0.765
2.007MetSer: 2.007 ± 0.709
2.676MetThr: 2.676 ± 1.278
0.334MetVal: 0.334 ± 0.304
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.013AsnAla: 4.013 ± 0.939
0.334AsnCys: 0.334 ± 0.27
2.341AsnAsp: 2.341 ± 0.893
2.341AsnGlu: 2.341 ± 0.825
2.676AsnPhe: 2.676 ± 0.651
3.01AsnGly: 3.01 ± 0.771
2.676AsnHis: 2.676 ± 1.003
4.013AsnIle: 4.013 ± 1.677
7.692AsnLys: 7.692 ± 2.18
6.02AsnLeu: 6.02 ± 1.281
2.007AsnMet: 2.007 ± 1.059
4.013AsnAsn: 4.013 ± 1.825
1.672AsnPro: 1.672 ± 0.71
4.682AsnGln: 4.682 ± 1.547
2.341AsnArg: 2.341 ± 0.863
4.682AsnSer: 4.682 ± 1.255
4.682AsnThr: 4.682 ± 1.229
2.007AsnVal: 2.007 ± 0.874
1.003AsnTrp: 1.003 ± 0.628
3.01AsnTyr: 3.01 ± 0.699
0.0AsnXaa: 0.0 ± 0.0
Pro
1.338ProAla: 1.338 ± 0.57
0.0ProCys: 0.0 ± 0.0
3.679ProAsp: 3.679 ± 1.076
2.341ProGlu: 2.341 ± 0.915
1.003ProPhe: 1.003 ± 0.447
0.334ProGly: 0.334 ± 0.304
0.334ProHis: 0.334 ± 0.336
1.672ProIle: 1.672 ± 0.744
4.682ProLys: 4.682 ± 1.406
1.003ProLeu: 1.003 ± 0.527
0.334ProMet: 0.334 ± 0.341
2.007ProAsn: 2.007 ± 0.685
1.672ProPro: 1.672 ± 0.768
0.669ProGln: 0.669 ± 0.314
2.676ProArg: 2.676 ± 0.874
0.669ProSer: 0.669 ± 0.443
0.669ProThr: 0.669 ± 0.413
1.672ProVal: 1.672 ± 0.487
0.0ProTrp: 0.0 ± 0.0
0.669ProTyr: 0.669 ± 0.364
0.0ProXaa: 0.0 ± 0.0
Gln
3.344GlnAla: 3.344 ± 0.82
0.334GlnCys: 0.334 ± 0.313
2.341GlnAsp: 2.341 ± 0.907
3.344GlnGlu: 3.344 ± 0.636
2.007GlnPhe: 2.007 ± 0.913
1.338GlnGly: 1.338 ± 0.685
0.334GlnHis: 0.334 ± 0.313
3.01GlnIle: 3.01 ± 0.655
4.348GlnLys: 4.348 ± 0.908
3.344GlnLeu: 3.344 ± 1.128
1.338GlnMet: 1.338 ± 0.739
2.676GlnAsn: 2.676 ± 0.92
1.338GlnPro: 1.338 ± 0.652
1.672GlnGln: 1.672 ± 0.795
1.003GlnArg: 1.003 ± 0.56
1.338GlnSer: 1.338 ± 0.622
2.007GlnThr: 2.007 ± 0.77
4.013GlnVal: 4.013 ± 0.887
0.334GlnTrp: 0.334 ± 0.27
2.007GlnTyr: 2.007 ± 0.935
0.0GlnXaa: 0.0 ± 0.0
Arg
1.338ArgAla: 1.338 ± 0.696
0.0ArgCys: 0.0 ± 0.0
2.007ArgAsp: 2.007 ± 0.784
6.02ArgGlu: 6.02 ± 1.284
1.672ArgPhe: 1.672 ± 0.756
1.338ArgGly: 1.338 ± 0.647
0.669ArgHis: 0.669 ± 0.364
3.01ArgIle: 3.01 ± 0.6
5.017ArgLys: 5.017 ± 1.083
6.355ArgLeu: 6.355 ± 1.575
1.003ArgMet: 1.003 ± 0.54
3.01ArgAsn: 3.01 ± 1.002
0.334ArgPro: 0.334 ± 0.304
2.007ArgGln: 2.007 ± 0.819
1.672ArgArg: 1.672 ± 0.913
2.676ArgSer: 2.676 ± 1.096
1.672ArgThr: 1.672 ± 0.596
1.338ArgVal: 1.338 ± 0.613
0.334ArgTrp: 0.334 ± 0.353
2.007ArgTyr: 2.007 ± 0.988
0.0ArgXaa: 0.0 ± 0.0
Ser
2.341SerAla: 2.341 ± 1.665
0.669SerCys: 0.669 ± 0.457
4.348SerAsp: 4.348 ± 0.699
6.02SerGlu: 6.02 ± 1.404
1.672SerPhe: 1.672 ± 0.688
5.017SerGly: 5.017 ± 0.996
1.003SerHis: 1.003 ± 0.453
4.348SerIle: 4.348 ± 0.861
6.355SerLys: 6.355 ± 1.502
6.02SerLeu: 6.02 ± 1.044
1.003SerMet: 1.003 ± 0.509
4.682SerAsn: 4.682 ± 1.301
1.338SerPro: 1.338 ± 0.413
1.672SerGln: 1.672 ± 0.722
2.341SerArg: 2.341 ± 0.969
4.348SerSer: 4.348 ± 1.561
3.344SerThr: 3.344 ± 0.98
2.676SerVal: 2.676 ± 0.617
0.334SerTrp: 0.334 ± 0.339
2.007SerTyr: 2.007 ± 0.797
0.0SerXaa: 0.0 ± 0.0
Thr
2.007ThrAla: 2.007 ± 0.753
0.334ThrCys: 0.334 ± 0.34
1.672ThrAsp: 1.672 ± 0.723
3.679ThrGlu: 3.679 ± 1.015
2.007ThrPhe: 2.007 ± 0.583
3.344ThrGly: 3.344 ± 1.094
1.003ThrHis: 1.003 ± 0.53
4.682ThrIle: 4.682 ± 1.332
6.02ThrLys: 6.02 ± 1.598
7.692ThrLeu: 7.692 ± 1.231
1.338ThrMet: 1.338 ± 0.56
3.344ThrAsn: 3.344 ± 1.056
2.341ThrPro: 2.341 ± 0.848
0.669ThrGln: 0.669 ± 0.451
1.672ThrArg: 1.672 ± 0.655
3.344ThrSer: 3.344 ± 0.949
5.017ThrThr: 5.017 ± 1.388
6.355ThrVal: 6.355 ± 1.676
0.669ThrTrp: 0.669 ± 0.466
4.013ThrTyr: 4.013 ± 1.402
0.0ThrXaa: 0.0 ± 0.0
Val
3.01ValAla: 3.01 ± 1.399
0.334ValCys: 0.334 ± 0.374
2.341ValAsp: 2.341 ± 1.01
5.017ValGlu: 5.017 ± 1.449
2.007ValPhe: 2.007 ± 1.022
3.344ValGly: 3.344 ± 1.188
0.0ValHis: 0.0 ± 0.0
3.01ValIle: 3.01 ± 0.848
5.017ValLys: 5.017 ± 1.289
3.679ValLeu: 3.679 ± 1.114
0.334ValMet: 0.334 ± 0.32
2.341ValAsn: 2.341 ± 0.708
1.003ValPro: 1.003 ± 0.535
2.676ValGln: 2.676 ± 1.16
1.672ValArg: 1.672 ± 0.667
3.01ValSer: 3.01 ± 1.05
2.676ValThr: 2.676 ± 0.699
2.341ValVal: 2.341 ± 0.984
0.0ValTrp: 0.0 ± 0.0
2.341ValTyr: 2.341 ± 0.915
0.0ValXaa: 0.0 ± 0.0
Trp
1.003TrpAla: 1.003 ± 0.447
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
1.672TrpGlu: 1.672 ± 0.738
0.0TrpPhe: 0.0 ± 0.0
0.334TrpGly: 0.334 ± 0.353
0.0TrpHis: 0.0 ± 0.0
0.669TrpIle: 0.669 ± 0.466
0.669TrpLys: 0.669 ± 0.453
1.003TrpLeu: 1.003 ± 0.628
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.669TrpSer: 0.669 ± 0.469
0.0TrpThr: 0.0 ± 0.0
0.334TrpVal: 0.334 ± 0.286
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
0.669TyrAla: 0.669 ± 0.539
1.003TyrCys: 1.003 ± 0.433
3.344TyrAsp: 3.344 ± 0.86
2.341TyrGlu: 2.341 ± 0.763
3.01TyrPhe: 3.01 ± 0.946
0.669TyrGly: 0.669 ± 0.493
0.334TyrHis: 0.334 ± 0.305
3.01TyrIle: 3.01 ± 1.058
5.351TyrLys: 5.351 ± 1.849
8.361TyrLeu: 8.361 ± 1.544
1.003TyrMet: 1.003 ± 0.537
2.007TyrAsn: 2.007 ± 0.559
2.007TyrPro: 2.007 ± 0.701
1.338TyrGln: 1.338 ± 0.685
2.341TyrArg: 2.341 ± 0.692
1.338TyrSer: 1.338 ± 0.711
3.344TyrThr: 3.344 ± 0.762
1.003TyrVal: 1.003 ± 0.636
0.334TyrTrp: 0.334 ± 0.314
0.669TyrTyr: 0.669 ± 0.453
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 20 proteins (2991 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski