Amino acid dipepetide frequency for Pontiella sulfatireligans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.642AlaAla: 8.642 ± 0.076	1.093AlaCys: 1.093 ± 0.025	5.721AlaAsp: 5.721 ± 0.052	6.103AlaGlu: 6.103 ± 0.058	3.508AlaPhe: 3.508 ± 0.038	7.966AlaGly: 7.966 ± 0.065	1.632AlaHis: 1.632 ± 0.027	4.463AlaIle: 4.463 ± 0.051	4.236AlaLys: 4.236 ± 0.055	8.2AlaLeu: 8.2 ± 0.066	2.391AlaMet: 2.391 ± 0.035	3.165AlaAsn: 3.165 ± 0.035	3.739AlaPro: 3.739 ± 0.05	2.807AlaGln: 2.807 ± 0.039	3.913AlaArg: 3.913 ± 0.046	5.533AlaSer: 5.533 ± 0.065	4.767AlaThr: 4.767 ± 0.06	6.642AlaVal: 6.642 ± 0.067	1.336AlaTrp: 1.336 ± 0.028	2.719AlaTyr: 2.719 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.076CysAla: 1.076 ± 0.024	0.211CysCys: 0.211 ± 0.009	0.734CysAsp: 0.734 ± 0.019	0.624CysGlu: 0.624 ± 0.016	0.542CysPhe: 0.542 ± 0.017	1.18CysGly: 1.18 ± 0.026	0.323CysHis: 0.323 ± 0.017	0.735CysIle: 0.735 ± 0.021	0.486CysLys: 0.486 ± 0.016	1.011CysLeu: 1.011 ± 0.023	0.304CysMet: 0.304 ± 0.012	0.438CysAsn: 0.438 ± 0.013	0.565CysPro: 0.565 ± 0.018	0.313CysGln: 0.313 ± 0.011	0.643CysArg: 0.643 ± 0.018	0.884CysSer: 0.884 ± 0.023	0.694CysThr: 0.694 ± 0.021	0.78CysVal: 0.78 ± 0.018	0.206CysTrp: 0.206 ± 0.01	0.428CysTyr: 0.428 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	5.606AspAla: 5.606 ± 0.061	0.651AspCys: 0.651 ± 0.02	3.483AspAsp: 3.483 ± 0.045	3.797AspGlu: 3.797 ± 0.047	2.76AspPhe: 2.76 ± 0.034	6.007AspGly: 6.007 ± 0.069	1.32AspHis: 1.32 ± 0.029	3.197AspIle: 3.197 ± 0.039	2.471AspLys: 2.471 ± 0.042	5.441AspLeu: 5.441 ± 0.061	1.414AspMet: 1.414 ± 0.026	2.357AspAsn: 2.357 ± 0.036	3.355AspPro: 3.355 ± 0.043	1.994AspGln: 1.994 ± 0.028	2.981AspArg: 2.981 ± 0.04	3.342AspSer: 3.342 ± 0.042	2.772AspThr: 2.772 ± 0.044	3.966AspVal: 3.966 ± 0.047	1.381AspTrp: 1.381 ± 0.025	2.374AspTyr: 2.374 ± 0.034	0.0AspXaa: 0.0 ± 0.0
Glu	5.561GluAla: 5.561 ± 0.062	0.615GluCys: 0.615 ± 0.018	2.995GluAsp: 2.995 ± 0.037	4.066GluGlu: 4.066 ± 0.057	2.441GluPhe: 2.441 ± 0.034	4.455GluGly: 4.455 ± 0.053	1.356GluHis: 1.356 ± 0.027	3.72GluIle: 3.72 ± 0.044	4.003GluLys: 4.003 ± 0.053	6.374GluLeu: 6.374 ± 0.065	1.791GluMet: 1.791 ± 0.03	2.821GluAsn: 2.821 ± 0.041	2.45GluPro: 2.45 ± 0.044	2.625GluGln: 2.625 ± 0.038	3.382GluArg: 3.382 ± 0.045	3.368GluSer: 3.368 ± 0.041	3.649GluThr: 3.649 ± 0.038	3.982GluVal: 3.982 ± 0.039	1.239GluTrp: 1.239 ± 0.025	2.134GluTyr: 2.134 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	3.303PheAla: 3.303 ± 0.038	0.659PheCys: 0.659 ± 0.018	3.086PheAsp: 3.086 ± 0.043	2.557PheGlu: 2.557 ± 0.032	1.893PhePhe: 1.893 ± 0.032	3.439PheGly: 3.439 ± 0.043	0.873PheHis: 0.873 ± 0.02	2.381PheIle: 2.381 ± 0.035	2.015PheLys: 2.015 ± 0.032	3.26PheLeu: 3.26 ± 0.049	1.106PheMet: 1.106 ± 0.019	1.861PheAsn: 1.861 ± 0.031	1.722PhePro: 1.722 ± 0.031	1.315PheGln: 1.315 ± 0.022	1.964PheArg: 1.964 ± 0.03	3.093PheSer: 3.093 ± 0.044	2.423PheThr: 2.423 ± 0.042	2.642PheVal: 2.642 ± 0.037	0.616PheTrp: 0.616 ± 0.017	1.488PheTyr: 1.488 ± 0.025	0.0PheXaa: 0.0 ± 0.0
Gly	6.655GlyAla: 6.655 ± 0.074	1.151GlyCys: 1.151 ± 0.029	4.654GlyAsp: 4.654 ± 0.056	4.689GlyGlu: 4.689 ± 0.049	3.688GlyPhe: 3.688 ± 0.037	7.029GlyGly: 7.029 ± 0.1	1.768GlyHis: 1.768 ± 0.026	4.977GlyIle: 4.977 ± 0.051	5.089GlyLys: 5.089 ± 0.061	7.074GlyLeu: 7.074 ± 0.059	2.415GlyMet: 2.415 ± 0.037	3.436GlyAsn: 3.436 ± 0.048	2.506GlyPro: 2.506 ± 0.035	2.539GlyGln: 2.539 ± 0.039	4.057GlyArg: 4.057 ± 0.048	5.332GlySer: 5.332 ± 0.071	5.328GlyThr: 5.328 ± 0.075	5.33GlyVal: 5.33 ± 0.053	1.555GlyTrp: 1.555 ± 0.032	3.096GlyTyr: 3.096 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.89HisAla: 1.89 ± 0.031	0.337HisCys: 0.337 ± 0.013	1.285HisAsp: 1.285 ± 0.026	1.203HisGlu: 1.203 ± 0.021	0.995HisPhe: 0.995 ± 0.024	1.879HisGly: 1.879 ± 0.032	0.687HisHis: 0.687 ± 0.019	1.192HisIle: 1.192 ± 0.024	0.837HisLys: 0.837 ± 0.02	2.026HisLeu: 2.026 ± 0.031	0.545HisMet: 0.545 ± 0.016	0.819HisAsn: 0.819 ± 0.021	1.377HisPro: 1.377 ± 0.028	0.619HisGln: 0.619 ± 0.018	1.151HisArg: 1.151 ± 0.023	1.252HisSer: 1.252 ± 0.025	1.062HisThr: 1.062 ± 0.023	1.329HisVal: 1.329 ± 0.024	0.444HisTrp: 0.444 ± 0.015	0.807HisTyr: 0.807 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	4.815IleAla: 4.815 ± 0.051	0.743IleCys: 0.743 ± 0.019	3.862IleAsp: 3.862 ± 0.042	3.809IleGlu: 3.809 ± 0.046	2.008IlePhe: 2.008 ± 0.032	4.411IleGly: 4.411 ± 0.055	1.278IleHis: 1.278 ± 0.026	2.84IleIle: 2.84 ± 0.043	2.713IleLys: 2.713 ± 0.04	4.41IleLeu: 4.41 ± 0.042	1.19IleMet: 1.19 ± 0.023	2.205IleAsn: 2.205 ± 0.034	2.861IlePro: 2.861 ± 0.039	1.884IleGln: 1.884 ± 0.033	3.039IleArg: 3.039 ± 0.039	3.439IleSer: 3.439 ± 0.043	3.062IleThr: 3.062 ± 0.041	3.564IleVal: 3.564 ± 0.041	0.73IleTrp: 0.73 ± 0.018	1.856IleTyr: 1.856 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	4.6LysAla: 4.6 ± 0.053	0.414LysCys: 0.414 ± 0.014	2.833LysAsp: 2.833 ± 0.039	3.33LysGlu: 3.33 ± 0.045	1.576LysPhe: 1.576 ± 0.027	3.875LysGly: 3.875 ± 0.053	1.17LysHis: 1.17 ± 0.026	2.69LysIle: 2.69 ± 0.04	3.968LysLys: 3.968 ± 0.072	4.454LysLeu: 4.454 ± 0.053	1.47LysMet: 1.47 ± 0.027	2.431LysAsn: 2.431 ± 0.042	2.735LysPro: 2.735 ± 0.04	2.005LysGln: 2.005 ± 0.037	2.719LysArg: 2.719 ± 0.038	2.813LysSer: 2.813 ± 0.039	3.432LysThr: 3.432 ± 0.046	3.216LysVal: 3.216 ± 0.043	0.942LysTrp: 0.942 ± 0.02	1.596LysTyr: 1.596 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	8.376LeuAla: 8.376 ± 0.066	1.194LeuCys: 1.194 ± 0.024	5.567LeuAsp: 5.567 ± 0.053	5.858LeuGlu: 5.858 ± 0.057	3.818LeuPhe: 3.818 ± 0.049	6.538LeuGly: 6.538 ± 0.057	1.804LeuHis: 1.804 ± 0.031	4.722LeuIle: 4.722 ± 0.056	5.025LeuLys: 5.025 ± 0.054	8.344LeuLeu: 8.344 ± 0.095	2.298LeuMet: 2.298 ± 0.038	3.649LeuAsn: 3.649 ± 0.047	4.435LeuPro: 4.435 ± 0.051	2.905LeuGln: 2.905 ± 0.043	4.445LeuArg: 4.445 ± 0.054	5.997LeuSer: 5.997 ± 0.055	4.941LeuThr: 4.941 ± 0.055	5.88LeuVal: 5.88 ± 0.061	1.184LeuTrp: 1.184 ± 0.03	2.887LeuTyr: 2.887 ± 0.042	0.0LeuXaa: 0.0 ± 0.0
Met	2.409MetAla: 2.409 ± 0.037	0.219MetCys: 0.219 ± 0.01	1.55MetAsp: 1.55 ± 0.027	1.553MetGlu: 1.553 ± 0.027	0.8MetPhe: 0.8 ± 0.021	1.984MetGly: 1.984 ± 0.031	0.574MetHis: 0.574 ± 0.018	1.421MetIle: 1.421 ± 0.025	2.057MetLys: 2.057 ± 0.033	2.384MetLeu: 2.384 ± 0.034	0.774MetMet: 0.774 ± 0.02	1.219MetAsn: 1.219 ± 0.022	1.316MetPro: 1.316 ± 0.027	0.886MetGln: 0.886 ± 0.02	1.376MetArg: 1.376 ± 0.026	1.391MetSer: 1.391 ± 0.024	1.429MetThr: 1.429 ± 0.027	1.763MetVal: 1.763 ± 0.027	0.294MetTrp: 0.294 ± 0.011	0.558MetTyr: 0.558 ± 0.018	0.0MetXaa: 0.0 ± 0.0
Asn	3.631AsnAla: 3.631 ± 0.047	0.504AsnCys: 0.504 ± 0.022	2.38AsnAsp: 2.38 ± 0.036	2.215AsnGlu: 2.215 ± 0.032	1.548AsnPhe: 1.548 ± 0.029	4.116AsnGly: 4.116 ± 0.052	0.914AsnHis: 0.914 ± 0.022	2.481AsnIle: 2.481 ± 0.035	1.743AsnLys: 1.743 ± 0.027	3.819AsnLeu: 3.819 ± 0.04	1.024AsnMet: 1.024 ± 0.02	1.831AsnAsn: 1.831 ± 0.034	2.682AsnPro: 2.682 ± 0.038	1.286AsnGln: 1.286 ± 0.023	2.076AsnArg: 2.076 ± 0.035	2.368AsnSer: 2.368 ± 0.047	2.387AsnThr: 2.387 ± 0.034	2.788AsnVal: 2.788 ± 0.039	0.77AsnTrp: 0.77 ± 0.019	1.436AsnTyr: 1.436 ± 0.027	0.0AsnXaa: 0.0 ± 0.0
Pro	4.349ProAla: 4.349 ± 0.05	0.468ProCys: 0.468 ± 0.017	3.411ProAsp: 3.411 ± 0.046	4.161ProGlu: 4.161 ± 0.044	2.113ProPhe: 2.113 ± 0.031	3.637ProGly: 3.637 ± 0.044	1.097ProHis: 1.097 ± 0.023	2.058ProIle: 2.058 ± 0.034	2.221ProLys: 2.221 ± 0.039	3.838ProLeu: 3.838 ± 0.043	1.144ProMet: 1.144 ± 0.026	2.046ProAsn: 2.046 ± 0.034	1.873ProPro: 1.873 ± 0.036	1.424ProGln: 1.424 ± 0.027	1.858ProArg: 1.858 ± 0.032	2.805ProSer: 2.805 ± 0.037	2.453ProThr: 2.453 ± 0.036	3.711ProVal: 3.711 ± 0.042	0.745ProTrp: 0.745 ± 0.02	1.529ProTyr: 1.529 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.062GlnAla: 3.062 ± 0.044	0.338GlnCys: 0.338 ± 0.012	1.505GlnAsp: 1.505 ± 0.027	1.852GlnGlu: 1.852 ± 0.034	1.299GlnPhe: 1.299 ± 0.027	2.41GlnGly: 2.41 ± 0.031	0.714GlnHis: 0.714 ± 0.02	1.892GlnIle: 1.892 ± 0.033	1.792GlnLys: 1.792 ± 0.029	3.292GlnLeu: 3.292 ± 0.039	0.924GlnMet: 0.924 ± 0.023	1.281GlnAsn: 1.281 ± 0.026	1.514GlnPro: 1.514 ± 0.025	1.359GlnGln: 1.359 ± 0.026	1.794GlnArg: 1.794 ± 0.028	1.92GlnSer: 1.92 ± 0.031	2.058GlnThr: 2.058 ± 0.035	2.112GlnVal: 2.112 ± 0.035	0.616GlnTrp: 0.616 ± 0.016	1.056GlnTyr: 1.056 ± 0.024	0.0GlnXaa: 0.0 ± 0.0
Arg	3.693ArgAla: 3.693 ± 0.046	0.632ArgCys: 0.632 ± 0.02	2.677ArgAsp: 2.677 ± 0.037	3.171ArgGlu: 3.171 ± 0.047	2.485ArgPhe: 2.485 ± 0.039	3.265ArgGly: 3.265 ± 0.042	1.103ArgHis: 1.103 ± 0.023	3.31ArgIle: 3.31 ± 0.04	2.873ArgLys: 2.873 ± 0.034	4.688ArgLeu: 4.688 ± 0.047	1.535ArgMet: 1.535 ± 0.025	2.184ArgAsn: 2.184 ± 0.033	2.115ArgPro: 2.115 ± 0.037	1.656ArgGln: 1.656 ± 0.033	2.72ArgArg: 2.72 ± 0.047	2.835ArgSer: 2.835 ± 0.039	2.601ArgThr: 2.601 ± 0.039	3.165ArgVal: 3.165 ± 0.041	0.903ArgTrp: 0.903 ± 0.019	1.878ArgTyr: 1.878 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	5.356SerAla: 5.356 ± 0.051	0.718SerCys: 0.718 ± 0.018	3.819SerAsp: 3.819 ± 0.047	3.405SerGlu: 3.405 ± 0.041	2.659SerPhe: 2.659 ± 0.035	6.122SerGly: 6.122 ± 0.083	1.266SerHis: 1.266 ± 0.023	3.517SerIle: 3.517 ± 0.044	2.861SerLys: 2.861 ± 0.038	5.36SerLeu: 5.36 ± 0.056	1.589SerMet: 1.589 ± 0.03	2.548SerAsn: 2.548 ± 0.04	2.806SerPro: 2.806 ± 0.04	1.663SerGln: 1.663 ± 0.028	2.923SerArg: 2.923 ± 0.037	3.964SerSer: 3.964 ± 0.06	3.348SerThr: 3.348 ± 0.05	4.47SerVal: 4.47 ± 0.052	1.072SerTrp: 1.072 ± 0.023	2.009SerTyr: 2.009 ± 0.029	0.0SerXaa: 0.0 ± 0.0
Thr	5.163ThrAla: 5.163 ± 0.065	0.582ThrCys: 0.582 ± 0.017	3.585ThrAsp: 3.585 ± 0.05	3.014ThrGlu: 3.014 ± 0.037	2.346ThrPhe: 2.346 ± 0.035	5.121ThrGly: 5.121 ± 0.056	1.179ThrHis: 1.179 ± 0.022	3.165ThrIle: 3.165 ± 0.044	2.059ThrLys: 2.059 ± 0.034	5.419ThrLeu: 5.419 ± 0.057	1.229ThrMet: 1.229 ± 0.021	2.749ThrAsn: 2.749 ± 0.066	3.111ThrPro: 3.111 ± 0.04	1.593ThrGln: 1.593 ± 0.027	2.267ThrArg: 2.267 ± 0.03	3.111ThrSer: 3.111 ± 0.044	3.012ThrThr: 3.012 ± 0.045	4.425ThrVal: 4.425 ± 0.053	0.827ThrTrp: 0.827 ± 0.021	1.819ThrTyr: 1.819 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	6.192ValAla: 6.192 ± 0.073	0.947ValCys: 0.947 ± 0.02	4.277ValAsp: 4.277 ± 0.053	4.661ValGlu: 4.661 ± 0.051	3.031ValPhe: 3.031 ± 0.04	4.792ValGly: 4.792 ± 0.054	1.377ValHis: 1.377 ± 0.025	3.448ValIle: 3.448 ± 0.038	3.182ValLys: 3.182 ± 0.042	6.296ValLeu: 6.296 ± 0.064	1.606ValMet: 1.606 ± 0.027	2.553ValAsn: 2.553 ± 0.033	3.327ValPro: 3.327 ± 0.039	2.186ValGln: 2.186 ± 0.035	3.433ValArg: 3.433 ± 0.041	4.747ValSer: 4.747 ± 0.053	3.513ValThr: 3.513 ± 0.045	5.26ValVal: 5.26 ± 0.062	1.046ValTrp: 1.046 ± 0.024	2.138ValTyr: 2.138 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.189TrpAla: 1.189 ± 0.026	0.21TrpCys: 0.21 ± 0.01	1.048TrpAsp: 1.048 ± 0.025	0.919TrpGlu: 0.919 ± 0.018	0.685TrpPhe: 0.685 ± 0.019	1.291TrpGly: 1.291 ± 0.025	0.501TrpHis: 0.501 ± 0.014	0.913TrpIle: 0.913 ± 0.019	1.138TrpLys: 1.138 ± 0.024	1.402TrpLeu: 1.402 ± 0.026	0.504TrpMet: 0.504 ± 0.018	0.946TrpAsn: 0.946 ± 0.023	0.751TrpPro: 0.751 ± 0.019	0.601TrpGln: 0.601 ± 0.016	0.864TrpArg: 0.864 ± 0.021	1.09TrpSer: 1.09 ± 0.027	0.952TrpThr: 0.952 ± 0.027	0.962TrpVal: 0.962 ± 0.02	0.28TrpTrp: 0.28 ± 0.012	0.54TrpTyr: 0.54 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.01TyrAla: 3.01 ± 0.043	0.495TyrCys: 0.495 ± 0.018	2.2TyrAsp: 2.2 ± 0.035	2.041TyrGlu: 2.041 ± 0.034	1.504TyrPhe: 1.504 ± 0.024	2.849TyrGly: 2.849 ± 0.041	0.8TyrHis: 0.8 ± 0.02	1.594TyrIle: 1.594 ± 0.028	1.497TyrLys: 1.497 ± 0.027	2.774TyrLeu: 2.774 ± 0.038	0.705TyrMet: 0.705 ± 0.02	1.46TyrAsn: 1.46 ± 0.028	1.701TyrPro: 1.701 ± 0.034	1.13TyrGln: 1.13 ± 0.022	1.885TyrArg: 1.885 ± 0.032	2.188TyrSer: 2.188 ± 0.033	1.895TyrThr: 1.895 ± 0.035	2.022TyrVal: 2.022 ± 0.031	0.599TyrTrp: 0.599 ± 0.02	1.313TyrTyr: 1.313 ± 0.032	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5575 proteins (2209931 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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