Amino acid dipepetide frequency for Pyrrhoderma noxium

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.167AlaAla: 6.167 ± 0.057	0.868AlaCys: 0.868 ± 0.013	3.266AlaAsp: 3.266 ± 0.029	4.105AlaGlu: 4.105 ± 0.037	2.901AlaPhe: 2.901 ± 0.027	4.474AlaGly: 4.474 ± 0.04	1.599AlaHis: 1.599 ± 0.018	3.855AlaIle: 3.855 ± 0.032	3.363AlaLys: 3.363 ± 0.038	7.014AlaLeu: 7.014 ± 0.046	1.413AlaMet: 1.413 ± 0.019	2.785AlaAsn: 2.785 ± 0.024	3.945AlaPro: 3.945 ± 0.039	2.718AlaGln: 2.718 ± 0.028	4.213AlaArg: 4.213 ± 0.036	7.29AlaSer: 7.29 ± 0.054	4.511AlaThr: 4.511 ± 0.035	4.254AlaVal: 4.254 ± 0.031	0.832AlaTrp: 0.832 ± 0.014	2.072AlaTyr: 2.072 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.77CysAla: 0.77 ± 0.015	0.218CysCys: 0.218 ± 0.007	0.602CysAsp: 0.602 ± 0.011	0.595CysGlu: 0.595 ± 0.013	0.569CysPhe: 0.569 ± 0.012	0.874CysGly: 0.874 ± 0.015	0.272CysHis: 0.272 ± 0.008	0.786CysIle: 0.786 ± 0.015	0.506CysLys: 0.506 ± 0.01	1.231CysLeu: 1.231 ± 0.02	0.228CysMet: 0.228 ± 0.007	0.428CysAsn: 0.428 ± 0.009	0.607CysPro: 0.607 ± 0.012	0.354CysGln: 0.354 ± 0.009	0.625CysArg: 0.625 ± 0.012	0.983CysSer: 0.983 ± 0.018	0.675CysThr: 0.675 ± 0.012	0.737CysVal: 0.737 ± 0.013	0.15CysTrp: 0.15 ± 0.005	0.336CysTyr: 0.336 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	3.932AspAla: 3.932 ± 0.033	0.611AspCys: 0.611 ± 0.013	4.014AspAsp: 4.014 ± 0.041	4.55AspGlu: 4.55 ± 0.042	2.102AspPhe: 2.102 ± 0.023	3.938AspGly: 3.938 ± 0.04	1.061AspHis: 1.061 ± 0.015	3.329AspIle: 3.329 ± 0.028	2.539AspLys: 2.539 ± 0.024	4.806AspLeu: 4.806 ± 0.034	1.126AspMet: 1.126 ± 0.013	2.156AspAsn: 2.156 ± 0.022	3.056AspPro: 3.056 ± 0.026	1.577AspGln: 1.577 ± 0.021	2.749AspArg: 2.749 ± 0.026	4.661AspSer: 4.661 ± 0.039	3.079AspThr: 3.079 ± 0.027	3.73AspVal: 3.73 ± 0.03	0.77AspTrp: 0.77 ± 0.013	1.562AspTyr: 1.562 ± 0.019	0.0AspXaa: 0.0 ± 0.0
Glu	4.471GluAla: 4.471 ± 0.04	0.674GluCys: 0.674 ± 0.013	4.22GluAsp: 4.22 ± 0.034	5.957GluGlu: 5.957 ± 0.063	1.94GluPhe: 1.94 ± 0.023	3.874GluGly: 3.874 ± 0.036	1.341GluHis: 1.341 ± 0.017	3.337GluIle: 3.337 ± 0.03	3.947GluLys: 3.947 ± 0.037	5.611GluLeu: 5.611 ± 0.043	1.299GluMet: 1.299 ± 0.015	2.721GluAsn: 2.721 ± 0.025	2.475GluPro: 2.475 ± 0.027	2.248GluGln: 2.248 ± 0.034	4.369GluArg: 4.369 ± 0.049	4.687GluSer: 4.687 ± 0.032	3.358GluThr: 3.358 ± 0.032	3.573GluVal: 3.573 ± 0.031	0.831GluTrp: 0.831 ± 0.015	1.78GluTyr: 1.78 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	2.748PheAla: 2.748 ± 0.026	0.509PheCys: 0.509 ± 0.01	2.278PheAsp: 2.278 ± 0.026	2.154PheGlu: 2.154 ± 0.021	1.691PhePhe: 1.691 ± 0.022	2.757PheGly: 2.757 ± 0.032	0.803PheHis: 0.803 ± 0.014	2.151PheIle: 2.151 ± 0.024	1.681PheLys: 1.681 ± 0.022	3.492PheLeu: 3.492 ± 0.03	0.716PheMet: 0.716 ± 0.012	1.555PheAsn: 1.555 ± 0.02	1.921PhePro: 1.921 ± 0.025	1.167PheGln: 1.167 ± 0.015	1.849PheArg: 1.849 ± 0.021	3.775PheSer: 3.775 ± 0.032	2.191PheThr: 2.191 ± 0.025	2.449PheVal: 2.449 ± 0.025	0.57PheTrp: 0.57 ± 0.01	1.124PheTyr: 1.124 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	4.38GlyAla: 4.38 ± 0.038	0.764GlyCys: 0.764 ± 0.015	3.365GlyAsp: 3.365 ± 0.034	3.7GlyGlu: 3.7 ± 0.032	2.464GlyPhe: 2.464 ± 0.029	5.412GlyGly: 5.412 ± 0.074	1.647GlyHis: 1.647 ± 0.024	3.501GlyIle: 3.501 ± 0.03	3.558GlyLys: 3.558 ± 0.033	5.489GlyLeu: 5.489 ± 0.035	1.393GlyMet: 1.393 ± 0.027	2.775GlyAsn: 2.775 ± 0.027	3.046GlyPro: 3.046 ± 0.03	2.13GlyGln: 2.13 ± 0.028	3.872GlyArg: 3.872 ± 0.034	6.597GlySer: 6.597 ± 0.061	4.115GlyThr: 4.115 ± 0.037	4.036GlyVal: 4.036 ± 0.038	0.973GlyTrp: 0.973 ± 0.015	1.92GlyTyr: 1.92 ± 0.023	0.0GlyXaa: 0.0 ± 0.0
His	1.59HisAla: 1.59 ± 0.021	0.275HisCys: 0.275 ± 0.008	1.151HisAsp: 1.151 ± 0.016	1.217HisGlu: 1.217 ± 0.017	0.893HisPhe: 0.893 ± 0.013	1.422HisGly: 1.422 ± 0.018	0.836HisHis: 0.836 ± 0.019	1.375HisIle: 1.375 ± 0.016	0.956HisLys: 0.956 ± 0.016	2.148HisLeu: 2.148 ± 0.023	0.416HisMet: 0.416 ± 0.01	0.889HisAsn: 0.889 ± 0.014	1.659HisPro: 1.659 ± 0.021	0.9HisGln: 0.9 ± 0.016	1.381HisArg: 1.381 ± 0.018	2.203HisSer: 2.203 ± 0.026	1.43HisThr: 1.43 ± 0.018	1.391HisVal: 1.391 ± 0.017	0.289HisTrp: 0.289 ± 0.009	0.693HisTyr: 0.693 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	3.897IleAla: 3.897 ± 0.03	0.813IleCys: 0.813 ± 0.014	3.042IleAsp: 3.042 ± 0.026	3.13IleGlu: 3.13 ± 0.034	2.142IlePhe: 2.142 ± 0.022	3.297IleGly: 3.297 ± 0.027	1.303IleHis: 1.303 ± 0.017	3.112IleIle: 3.112 ± 0.03	2.661IleLys: 2.661 ± 0.027	5.144IleLeu: 5.144 ± 0.043	1.026IleMet: 1.026 ± 0.015	2.228IleAsn: 2.228 ± 0.024	3.488IlePro: 3.488 ± 0.027	1.993IleGln: 1.993 ± 0.022	3.148IleArg: 3.148 ± 0.027	5.036IleSer: 5.036 ± 0.032	3.184IleThr: 3.184 ± 0.025	3.375IleVal: 3.375 ± 0.029	0.906IleTrp: 0.906 ± 0.02	1.565IleTyr: 1.565 ± 0.021	0.0IleXaa: 0.0 ± 0.0
Lys	3.719LysAla: 3.719 ± 0.04	0.533LysCys: 0.533 ± 0.012	2.931LysAsp: 2.931 ± 0.031	3.989LysGlu: 3.989 ± 0.04	1.549LysPhe: 1.549 ± 0.019	3.128LysGly: 3.128 ± 0.026	1.112LysHis: 1.112 ± 0.017	2.507LysIle: 2.507 ± 0.025	3.766LysLys: 3.766 ± 0.047	4.5LysLeu: 4.5 ± 0.037	0.944LysMet: 0.944 ± 0.014	2.115LysAsn: 2.115 ± 0.024	2.568LysPro: 2.568 ± 0.03	1.828LysGln: 1.828 ± 0.024	3.727LysArg: 3.727 ± 0.035	4.107LysSer: 4.107 ± 0.034	2.896LysThr: 2.896 ± 0.028	2.796LysVal: 2.796 ± 0.027	0.66LysTrp: 0.66 ± 0.013	1.486LysTyr: 1.486 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	6.697LeuAla: 6.697 ± 0.042	1.16LeuCys: 1.16 ± 0.018	5.01LeuAsp: 5.01 ± 0.036	5.514LeuGlu: 5.514 ± 0.054	3.513LeuPhe: 3.513 ± 0.038	5.565LeuGly: 5.565 ± 0.038	2.153LeuHis: 2.153 ± 0.025	4.47LeuIle: 4.47 ± 0.038	4.646LeuLys: 4.646 ± 0.042	8.556LeuLeu: 8.556 ± 0.061	1.624LeuMet: 1.624 ± 0.018	3.653LeuAsn: 3.653 ± 0.031	5.563LeuPro: 5.563 ± 0.043	3.419LeuGln: 3.419 ± 0.031	5.656LeuArg: 5.656 ± 0.043	8.779LeuSer: 8.779 ± 0.045	5.073LeuThr: 5.073 ± 0.033	5.415LeuVal: 5.415 ± 0.039	1.083LeuTrp: 1.083 ± 0.016	2.524LeuTyr: 2.524 ± 0.031	0.0LeuXaa: 0.0 ± 0.0
Met	1.475MetAla: 1.475 ± 0.02	0.208MetCys: 0.208 ± 0.006	1.185MetAsp: 1.185 ± 0.015	1.141MetGlu: 1.141 ± 0.017	0.695MetPhe: 0.695 ± 0.013	1.257MetGly: 1.257 ± 0.023	0.48MetHis: 0.48 ± 0.009	0.957MetIle: 0.957 ± 0.016	1.02MetLys: 1.02 ± 0.014	1.595MetLeu: 1.595 ± 0.018	0.474MetMet: 0.474 ± 0.011	0.892MetAsn: 0.892 ± 0.015	1.022MetPro: 1.022 ± 0.016	0.703MetGln: 0.703 ± 0.013	1.169MetArg: 1.169 ± 0.016	2.02MetSer: 2.02 ± 0.02	1.168MetThr: 1.168 ± 0.016	0.973MetVal: 0.973 ± 0.014	0.245MetTrp: 0.245 ± 0.007	0.531MetTyr: 0.531 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.026AsnAla: 3.026 ± 0.024	0.449AsnCys: 0.449 ± 0.009	2.218AsnAsp: 2.218 ± 0.023	2.529AsnGlu: 2.529 ± 0.025	1.478AsnPhe: 1.478 ± 0.018	3.144AsnGly: 3.144 ± 0.032	0.906AsnHis: 0.906 ± 0.016	2.552AsnIle: 2.552 ± 0.022	1.97AsnLys: 1.97 ± 0.024	3.544AsnLeu: 3.544 ± 0.031	0.866AsnMet: 0.866 ± 0.014	2.239AsnAsn: 2.239 ± 0.041	2.467AsnPro: 2.467 ± 0.024	1.494AsnGln: 1.494 ± 0.018	2.049AsnArg: 2.049 ± 0.02	3.882AsnSer: 3.882 ± 0.035	2.797AsnThr: 2.797 ± 0.025	2.702AsnVal: 2.702 ± 0.026	0.527AsnTrp: 0.527 ± 0.012	1.171AsnTyr: 1.171 ± 0.016	0.0AsnXaa: 0.0 ± 0.0
Pro	3.833ProAla: 3.833 ± 0.034	0.479ProCys: 0.479 ± 0.011	3.023ProAsp: 3.023 ± 0.028	3.574ProGlu: 3.574 ± 0.029	2.161ProPhe: 2.161 ± 0.026	3.429ProGly: 3.429 ± 0.034	1.334ProHis: 1.334 ± 0.017	3.028ProIle: 3.028 ± 0.028	2.603ProLys: 2.603 ± 0.027	5.023ProLeu: 5.023 ± 0.036	0.933ProMet: 0.933 ± 0.016	2.326ProAsn: 2.326 ± 0.024	5.403ProPro: 5.403 ± 0.085	2.233ProGln: 2.233 ± 0.032	3.138ProArg: 3.138 ± 0.037	7.064ProSer: 7.064 ± 0.062	4.03ProThr: 4.03 ± 0.039	3.505ProVal: 3.505 ± 0.038	0.576ProTrp: 0.576 ± 0.012	1.563ProTyr: 1.563 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	2.763GlnAla: 2.763 ± 0.028	0.4GlnCys: 0.4 ± 0.009	1.78GlnAsp: 1.78 ± 0.019	2.234GlnGlu: 2.234 ± 0.026	1.207GlnPhe: 1.207 ± 0.016	2.057GlnGly: 2.057 ± 0.027	0.956GlnHis: 0.956 ± 0.017	1.961GlnIle: 1.961 ± 0.023	1.826GlnLys: 1.826 ± 0.024	3.197GlnLeu: 3.197 ± 0.032	0.764GlnMet: 0.764 ± 0.012	1.673GlnAsn: 1.673 ± 0.023	2.037GlnPro: 2.037 ± 0.031	2.267GlnGln: 2.267 ± 0.055	2.312GlnArg: 2.312 ± 0.027	3.201GlnSer: 3.201 ± 0.034	2.336GlnThr: 2.336 ± 0.023	2.029GlnVal: 2.029 ± 0.021	0.404GlnTrp: 0.404 ± 0.009	1.014GlnTyr: 1.014 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	4.199ArgAla: 4.199 ± 0.034	0.647ArgCys: 0.647 ± 0.013	3.291ArgAsp: 3.291 ± 0.031	4.025ArgGlu: 4.025 ± 0.041	2.086ArgPhe: 2.086 ± 0.023	3.479ArgGly: 3.479 ± 0.035	1.389ArgHis: 1.389 ± 0.017	3.354ArgIle: 3.354 ± 0.03	3.601ArgLys: 3.601 ± 0.032	5.158ArgLeu: 5.158 ± 0.042	1.247ArgMet: 1.247 ± 0.016	2.424ArgAsn: 2.424 ± 0.024	3.245ArgPro: 3.245 ± 0.035	2.163ArgGln: 2.163 ± 0.026	5.002ArgArg: 5.002 ± 0.052	5.37ArgSer: 5.37 ± 0.051	3.389ArgThr: 3.389 ± 0.029	3.532ArgVal: 3.532 ± 0.029	0.774ArgTrp: 0.774 ± 0.012	1.601ArgTyr: 1.601 ± 0.018	0.0ArgXaa: 0.0 ± 0.0
Ser	6.527SerAla: 6.527 ± 0.05	0.958SerCys: 0.958 ± 0.015	4.922SerAsp: 4.922 ± 0.038	5.111SerGlu: 5.111 ± 0.042	3.616SerPhe: 3.616 ± 0.034	6.709SerGly: 6.709 ± 0.057	2.133SerHis: 2.133 ± 0.024	5.026SerIle: 5.026 ± 0.033	4.339SerLys: 4.339 ± 0.039	8.502SerLeu: 8.502 ± 0.054	1.713SerMet: 1.713 ± 0.02	4.027SerAsn: 4.027 ± 0.036	6.656SerPro: 6.656 ± 0.068	3.515SerGln: 3.515 ± 0.031	5.697SerArg: 5.697 ± 0.051	12.74SerSer: 12.74 ± 0.119	6.9SerThr: 6.9 ± 0.057	5.581SerVal: 5.581 ± 0.04	1.031SerTrp: 1.031 ± 0.016	2.33SerTyr: 2.33 ± 0.025	0.0SerXaa: 0.0 ± 0.0
Thr	4.265ThrAla: 4.265 ± 0.036	0.661ThrCys: 0.661 ± 0.012	2.831ThrAsp: 2.831 ± 0.031	3.114ThrGlu: 3.114 ± 0.03	2.403ThrPhe: 2.403 ± 0.024	4.059ThrGly: 4.059 ± 0.046	1.385ThrHis: 1.385 ± 0.021	3.555ThrIle: 3.555 ± 0.034	2.825ThrLys: 2.825 ± 0.027	5.618ThrLeu: 5.618 ± 0.04	1.042ThrMet: 1.042 ± 0.016	2.604ThrAsn: 2.604 ± 0.026	4.472ThrPro: 4.472 ± 0.045	2.133ThrGln: 2.133 ± 0.029	3.394ThrArg: 3.394 ± 0.03	6.794ThrSer: 6.794 ± 0.056	4.619ThrThr: 4.619 ± 0.063	3.571ThrVal: 3.571 ± 0.027	0.712ThrTrp: 0.712 ± 0.014	1.612ThrTyr: 1.612 ± 0.02	0.0ThrXaa: 0.0 ± 0.0
Val	4.355ValAla: 4.355 ± 0.032	0.783ValCys: 0.783 ± 0.015	3.534ValAsp: 3.534 ± 0.03	3.688ValGlu: 3.688 ± 0.027	2.45ValPhe: 2.45 ± 0.024	3.66ValGly: 3.66 ± 0.034	1.422ValHis: 1.422 ± 0.016	3.206ValIle: 3.206 ± 0.024	3.012ValLys: 3.012 ± 0.031	5.697ValLeu: 5.697 ± 0.039	1.124ValMet: 1.124 ± 0.017	2.522ValAsn: 2.522 ± 0.024	3.627ValPro: 3.627 ± 0.032	2.21ValGln: 2.21 ± 0.022	3.287ValArg: 3.287 ± 0.036	5.331ValSer: 5.331 ± 0.037	3.464ValThr: 3.464 ± 0.031	3.978ValVal: 3.978 ± 0.031	0.872ValTrp: 0.872 ± 0.016	1.84ValTyr: 1.84 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	0.919TrpAla: 0.919 ± 0.015	0.161TrpCys: 0.161 ± 0.005	1.01TrpAsp: 1.01 ± 0.022	0.777TrpGlu: 0.777 ± 0.012	0.505TrpPhe: 0.505 ± 0.01	0.785TrpGly: 0.785 ± 0.013	0.283TrpHis: 0.283 ± 0.008	0.764TrpIle: 0.764 ± 0.013	0.761TrpLys: 0.761 ± 0.014	1.089TrpLeu: 1.089 ± 0.016	0.304TrpMet: 0.304 ± 0.009	0.667TrpAsn: 0.667 ± 0.015	0.487TrpPro: 0.487 ± 0.011	0.361TrpGln: 0.361 ± 0.009	0.764TrpArg: 0.764 ± 0.014	0.998TrpSer: 0.998 ± 0.014	0.778TrpThr: 0.778 ± 0.014	0.799TrpVal: 0.799 ± 0.014	0.237TrpTrp: 0.237 ± 0.007	0.362TrpTyr: 0.362 ± 0.009	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.914TyrAla: 1.914 ± 0.02	0.375TyrCys: 0.375 ± 0.009	1.672TyrAsp: 1.672 ± 0.02	1.607TyrGlu: 1.607 ± 0.021	1.218TyrPhe: 1.218 ± 0.017	1.818TyrGly: 1.818 ± 0.025	0.701TyrHis: 0.701 ± 0.015	1.665TyrIle: 1.665 ± 0.024	1.282TyrLys: 1.282 ± 0.02	2.66TyrLeu: 2.66 ± 0.029	0.559TyrMet: 0.559 ± 0.011	1.332TyrAsn: 1.332 ± 0.018	1.515TyrPro: 1.515 ± 0.022	1.003TyrGln: 1.003 ± 0.022	1.57TyrArg: 1.57 ± 0.018	2.514TyrSer: 2.514 ± 0.028	1.677TyrThr: 1.677 ± 0.019	1.635TyrVal: 1.635 ± 0.02	0.366TyrTrp: 0.366 ± 0.009	0.966TyrTyr: 0.966 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9911 proteins (4934286 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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