Amino acid dipepetide frequency for Xanthomonas phage Xoo-sp15

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.707AlaAla: 2.707 ± 0.418
0.387AlaCys: 0.387 ± 0.091
3.394AlaAsp: 3.394 ± 0.257
4.512AlaGlu: 4.512 ± 0.299
2.449AlaPhe: 2.449 ± 0.21
4.727AlaGly: 4.727 ± 0.422
0.881AlaHis: 0.881 ± 0.14
3.889AlaIle: 3.889 ± 0.3
4.748AlaLys: 4.748 ± 0.322
4.898AlaLeu: 4.898 ± 0.338
1.568AlaMet: 1.568 ± 0.183
3.051AlaAsn: 3.051 ± 0.327
2.062AlaPro: 2.062 ± 0.324
2.686AlaGln: 2.686 ± 0.25
2.406AlaArg: 2.406 ± 0.257
3.244AlaSer: 3.244 ± 0.321
4.619AlaThr: 4.619 ± 0.478
3.781AlaVal: 3.781 ± 0.334
0.752AlaTrp: 0.752 ± 0.098
2.707AlaTyr: 2.707 ± 0.266
0.0AlaXaa: 0.0 ± 0.0
Cys
0.322CysAla: 0.322 ± 0.086
0.129CysCys: 0.129 ± 0.054
0.58CysAsp: 0.58 ± 0.129
0.687CysGlu: 0.687 ± 0.139
0.279CysPhe: 0.279 ± 0.074
0.795CysGly: 0.795 ± 0.139
0.258CysHis: 0.258 ± 0.075
0.473CysIle: 0.473 ± 0.111
0.773CysLys: 0.773 ± 0.168
0.58CysLeu: 0.58 ± 0.109
0.193CysMet: 0.193 ± 0.058
0.387CysAsn: 0.387 ± 0.093
0.365CysPro: 0.365 ± 0.093
0.172CysGln: 0.172 ± 0.053
0.344CysArg: 0.344 ± 0.081
0.602CysSer: 0.602 ± 0.109
0.537CysThr: 0.537 ± 0.118
0.494CysVal: 0.494 ± 0.095
0.107CysTrp: 0.107 ± 0.05
0.494CysTyr: 0.494 ± 0.113
0.0CysXaa: 0.0 ± 0.0
Asp
3.695AspAla: 3.695 ± 0.323
0.709AspCys: 0.709 ± 0.115
3.846AspAsp: 3.846 ± 0.348
4.555AspGlu: 4.555 ± 0.292
2.793AspPhe: 2.793 ± 0.209
4.018AspGly: 4.018 ± 0.336
1.074AspHis: 1.074 ± 0.189
5.156AspIle: 5.156 ± 0.315
5.478AspLys: 5.478 ± 0.381
5.178AspLeu: 5.178 ± 0.31
1.568AspMet: 1.568 ± 0.183
3.609AspAsn: 3.609 ± 0.308
2.17AspPro: 2.17 ± 0.228
1.353AspGln: 1.353 ± 0.176
2.728AspArg: 2.728 ± 0.229
3.309AspSer: 3.309 ± 0.243
3.652AspThr: 3.652 ± 0.299
4.812AspVal: 4.812 ± 0.329
1.01AspTrp: 1.01 ± 0.157
3.502AspTyr: 3.502 ± 0.275
0.0AspXaa: 0.0 ± 0.0
Glu
4.211GluAla: 4.211 ± 0.34
0.602GluCys: 0.602 ± 0.113
5.693GluAsp: 5.693 ± 0.47
8.465GluGlu: 8.465 ± 0.671
3.051GluPhe: 3.051 ± 0.292
5.027GluGly: 5.027 ± 0.322
1.332GluHis: 1.332 ± 0.205
5.135GluIle: 5.135 ± 0.351
6.252GluLys: 6.252 ± 0.387
7.455GluLeu: 7.455 ± 0.447
2.557GluMet: 2.557 ± 0.275
3.781GluAsn: 3.781 ± 0.293
2.105GluPro: 2.105 ± 0.365
3.266GluGln: 3.266 ± 0.321
3.48GluArg: 3.48 ± 0.284
3.545GluSer: 3.545 ± 0.292
3.566GluThr: 3.566 ± 0.273
5.264GluVal: 5.264 ± 0.38
0.924GluTrp: 0.924 ± 0.107
3.566GluTyr: 3.566 ± 0.264
0.0GluXaa: 0.0 ± 0.0
Phe
2.084PheAla: 2.084 ± 0.173
0.516PheCys: 0.516 ± 0.093
2.771PheAsp: 2.771 ± 0.235
2.793PheGlu: 2.793 ± 0.248
1.482PhePhe: 1.482 ± 0.179
2.471PheGly: 2.471 ± 0.218
0.902PheHis: 0.902 ± 0.179
2.385PheIle: 2.385 ± 0.233
3.094PheLys: 3.094 ± 0.225
2.814PheLeu: 2.814 ± 0.268
1.16PheMet: 1.16 ± 0.153
2.256PheAsn: 2.256 ± 0.237
1.053PhePro: 1.053 ± 0.139
1.16PheGln: 1.16 ± 0.191
1.439PheArg: 1.439 ± 0.146
2.986PheSer: 2.986 ± 0.256
2.664PheThr: 2.664 ± 0.308
2.728PheVal: 2.728 ± 0.27
0.236PheTrp: 0.236 ± 0.067
1.633PheTyr: 1.633 ± 0.185
0.0PheXaa: 0.0 ± 0.0
Gly
3.523GlyAla: 3.523 ± 0.402
0.73GlyCys: 0.73 ± 0.145
3.91GlyAsp: 3.91 ± 0.271
4.404GlyGlu: 4.404 ± 0.323
2.492GlyPhe: 2.492 ± 0.28
5.564GlyGly: 5.564 ± 0.738
1.311GlyHis: 1.311 ± 0.164
4.254GlyIle: 4.254 ± 0.324
5.371GlyLys: 5.371 ± 0.274
4.748GlyLeu: 4.748 ± 0.358
1.977GlyMet: 1.977 ± 0.269
3.91GlyAsn: 3.91 ± 0.403
0.086GlyPro: 0.086 ± 0.059
2.643GlyGln: 2.643 ± 0.26
2.621GlyArg: 2.621 ± 0.23
4.963GlySer: 4.963 ± 0.443
5.264GlyThr: 5.264 ± 0.414
4.834GlyVal: 4.834 ± 0.326
1.053GlyTrp: 1.053 ± 0.167
3.051GlyTyr: 3.051 ± 0.262
0.0GlyXaa: 0.0 ± 0.0
His
0.967HisAla: 0.967 ± 0.156
0.236HisCys: 0.236 ± 0.078
0.838HisAsp: 0.838 ± 0.133
1.289HisGlu: 1.289 ± 0.198
0.666HisPhe: 0.666 ± 0.142
0.881HisGly: 0.881 ± 0.155
0.322HisHis: 0.322 ± 0.09
1.311HisIle: 1.311 ± 0.195
1.332HisLys: 1.332 ± 0.186
1.547HisLeu: 1.547 ± 0.207
0.451HisMet: 0.451 ± 0.111
0.924HisAsn: 0.924 ± 0.145
0.537HisPro: 0.537 ± 0.109
0.451HisGln: 0.451 ± 0.098
1.332HisArg: 1.332 ± 0.178
0.838HisSer: 0.838 ± 0.129
1.182HisThr: 1.182 ± 0.17
1.676HisVal: 1.676 ± 0.189
0.258HisTrp: 0.258 ± 0.078
0.881HisTyr: 0.881 ± 0.157
0.0HisXaa: 0.0 ± 0.0
Ile
4.469IleAla: 4.469 ± 0.294
0.344IleCys: 0.344 ± 0.107
3.867IleAsp: 3.867 ± 0.297
5.414IleGlu: 5.414 ± 0.359
1.998IlePhe: 1.998 ± 0.206
3.889IleGly: 3.889 ± 0.295
1.504IleHis: 1.504 ± 0.194
3.33IleIle: 3.33 ± 0.28
5.457IleLys: 5.457 ± 0.336
4.103IleLeu: 4.103 ± 0.358
1.74IleMet: 1.74 ± 0.211
3.889IleAsn: 3.889 ± 0.302
2.449IlePro: 2.449 ± 0.236
1.934IleGln: 1.934 ± 0.182
3.072IleArg: 3.072 ± 0.258
4.383IleSer: 4.383 ± 0.306
4.49IleThr: 4.49 ± 0.377
4.555IleVal: 4.555 ± 0.365
0.473IleTrp: 0.473 ± 0.095
2.191IleTyr: 2.191 ± 0.19
0.0IleXaa: 0.0 ± 0.0
Lys
4.855LysAla: 4.855 ± 0.349
0.365LysCys: 0.365 ± 0.108
5.371LysAsp: 5.371 ± 0.396
8.336LysGlu: 8.336 ± 0.626
2.9LysPhe: 2.9 ± 0.221
4.769LysGly: 4.769 ± 0.317
1.396LysHis: 1.396 ± 0.178
3.975LysIle: 3.975 ± 0.283
6.101LysLys: 6.101 ± 0.493
5.973LysLeu: 5.973 ± 0.397
2.406LysMet: 2.406 ± 0.227
3.889LysAsn: 3.889 ± 0.307
2.879LysPro: 2.879 ± 0.332
3.502LysGln: 3.502 ± 0.257
3.48LysArg: 3.48 ± 0.264
3.953LysSer: 3.953 ± 0.388
3.889LysThr: 3.889 ± 0.302
5.93LysVal: 5.93 ± 0.303
1.053LysTrp: 1.053 ± 0.144
3.266LysTyr: 3.266 ± 0.346
0.0LysXaa: 0.0 ± 0.0
Leu
5.35LeuAla: 5.35 ± 0.349
0.623LeuCys: 0.623 ± 0.111
5.5LeuAsp: 5.5 ± 0.396
6.961LeuGlu: 6.961 ± 0.525
3.437LeuPhe: 3.437 ± 0.286
4.984LeuGly: 4.984 ± 0.353
1.332LeuHis: 1.332 ± 0.182
4.469LeuIle: 4.469 ± 0.415
6.144LeuLys: 6.144 ± 0.327
6.316LeuLeu: 6.316 ± 0.534
1.934LeuMet: 1.934 ± 0.229
4.018LeuAsn: 4.018 ± 0.255
2.836LeuPro: 2.836 ± 0.287
3.717LeuGln: 3.717 ± 0.281
3.631LeuArg: 3.631 ± 0.308
4.361LeuSer: 4.361 ± 0.279
5.199LeuThr: 5.199 ± 0.343
5.264LeuVal: 5.264 ± 0.401
0.752LeuTrp: 0.752 ± 0.134
3.223LeuTyr: 3.223 ± 0.249
0.0LeuXaa: 0.0 ± 0.0
Met
1.848MetAla: 1.848 ± 0.179
0.15MetCys: 0.15 ± 0.065
1.762MetAsp: 1.762 ± 0.2
2.299MetGlu: 2.299 ± 0.222
1.074MetPhe: 1.074 ± 0.15
1.353MetGly: 1.353 ± 0.211
0.387MetHis: 0.387 ± 0.089
1.848MetIle: 1.848 ± 0.218
2.643MetLys: 2.643 ± 0.254
2.148MetLeu: 2.148 ± 0.235
0.773MetMet: 0.773 ± 0.119
1.633MetAsn: 1.633 ± 0.199
0.773MetPro: 0.773 ± 0.167
0.795MetGln: 0.795 ± 0.155
1.375MetArg: 1.375 ± 0.169
1.719MetSer: 1.719 ± 0.233
1.998MetThr: 1.998 ± 0.214
1.74MetVal: 1.74 ± 0.19
0.279MetTrp: 0.279 ± 0.083
0.881MetTyr: 0.881 ± 0.172
0.0MetXaa: 0.0 ± 0.0
Asn
3.266AsnAla: 3.266 ± 0.306
0.709AsnCys: 0.709 ± 0.173
2.535AsnAsp: 2.535 ± 0.23
3.394AsnGlu: 3.394 ± 0.302
1.955AsnPhe: 1.955 ± 0.239
4.555AsnGly: 4.555 ± 0.425
0.945AsnHis: 0.945 ± 0.156
4.039AsnIle: 4.039 ± 0.285
4.06AsnLys: 4.06 ± 0.302
4.383AsnLeu: 4.383 ± 0.314
1.654AsnMet: 1.654 ± 0.173
3.051AsnAsn: 3.051 ± 0.402
2.449AsnPro: 2.449 ± 0.248
1.697AsnGln: 1.697 ± 0.173
2.385AsnArg: 2.385 ± 0.257
2.621AsnSer: 2.621 ± 0.274
3.244AsnThr: 3.244 ± 0.341
3.652AsnVal: 3.652 ± 0.242
0.494AsnTrp: 0.494 ± 0.097
2.105AsnTyr: 2.105 ± 0.169
0.0AsnXaa: 0.0 ± 0.0
Pro
1.568ProAla: 1.568 ± 0.242
0.279ProCys: 0.279 ± 0.074
2.062ProAsp: 2.062 ± 0.236
2.191ProGlu: 2.191 ± 0.232
1.289ProPhe: 1.289 ± 0.179
1.246ProGly: 1.246 ± 0.193
0.58ProHis: 0.58 ± 0.108
2.191ProIle: 2.191 ± 0.22
2.857ProLys: 2.857 ± 0.256
2.363ProLeu: 2.363 ± 0.238
0.988ProMet: 0.988 ± 0.16
1.654ProAsn: 1.654 ± 0.23
0.816ProPro: 0.816 ± 0.127
1.439ProGln: 1.439 ± 0.221
1.16ProArg: 1.16 ± 0.149
2.062ProSer: 2.062 ± 0.25
2.342ProThr: 2.342 ± 0.397
2.664ProVal: 2.664 ± 0.3
0.193ProTrp: 0.193 ± 0.064
1.396ProTyr: 1.396 ± 0.171
0.0ProXaa: 0.0 ± 0.0
Gln
2.943GlnAla: 2.943 ± 0.281
0.387GlnCys: 0.387 ± 0.102
2.17GlnAsp: 2.17 ± 0.232
2.986GlnGlu: 2.986 ± 0.246
1.139GlnPhe: 1.139 ± 0.143
2.514GlnGly: 2.514 ± 0.266
0.773GlnHis: 0.773 ± 0.14
1.869GlnIle: 1.869 ± 0.196
2.428GlnLys: 2.428 ± 0.251
3.115GlnLeu: 3.115 ± 0.276
0.816GlnMet: 0.816 ± 0.142
1.912GlnAsn: 1.912 ± 0.154
1.611GlnPro: 1.611 ± 0.329
1.891GlnGln: 1.891 ± 0.246
1.461GlnArg: 1.461 ± 0.18
2.148GlnSer: 2.148 ± 0.201
1.955GlnThr: 1.955 ± 0.205
2.857GlnVal: 2.857 ± 0.213
0.451GlnTrp: 0.451 ± 0.084
1.289GlnTyr: 1.289 ± 0.173
0.0GlnXaa: 0.0 ± 0.0
Arg
2.213ArgAla: 2.213 ± 0.217
0.301ArgCys: 0.301 ± 0.085
2.643ArgAsp: 2.643 ± 0.219
3.781ArgGlu: 3.781 ± 0.308
1.719ArgPhe: 1.719 ± 0.185
2.707ArgGly: 2.707 ± 0.223
0.58ArgHis: 0.58 ± 0.107
2.728ArgIle: 2.728 ± 0.233
3.137ArgLys: 3.137 ± 0.307
3.695ArgLeu: 3.695 ± 0.279
1.633ArgMet: 1.633 ± 0.199
2.234ArgAsn: 2.234 ± 0.243
1.268ArgPro: 1.268 ± 0.166
1.547ArgGln: 1.547 ± 0.177
1.955ArgArg: 1.955 ± 0.217
2.256ArgSer: 2.256 ± 0.234
2.621ArgThr: 2.621 ± 0.219
3.588ArgVal: 3.588 ± 0.313
0.687ArgTrp: 0.687 ± 0.14
2.32ArgTyr: 2.32 ± 0.233
0.0ArgXaa: 0.0 ± 0.0
Ser
3.244SerAla: 3.244 ± 0.332
0.43SerCys: 0.43 ± 0.118
4.103SerAsp: 4.103 ± 0.313
3.523SerGlu: 3.523 ± 0.309
2.771SerPhe: 2.771 ± 0.232
4.297SerGly: 4.297 ± 0.349
0.709SerHis: 0.709 ± 0.114
3.695SerIle: 3.695 ± 0.325
4.232SerLys: 4.232 ± 0.294
5.07SerLeu: 5.07 ± 0.287
1.611SerMet: 1.611 ± 0.214
3.051SerAsn: 3.051 ± 0.333
1.826SerPro: 1.826 ± 0.2
1.719SerGln: 1.719 ± 0.175
2.6SerArg: 2.6 ± 0.257
4.232SerSer: 4.232 ± 0.596
3.588SerThr: 3.588 ± 0.374
4.254SerVal: 4.254 ± 0.265
0.902SerTrp: 0.902 ± 0.177
2.707SerTyr: 2.707 ± 0.285
0.0SerXaa: 0.0 ± 0.0
Thr
3.846ThrAla: 3.846 ± 0.445
0.516ThrCys: 0.516 ± 0.108
3.867ThrAsp: 3.867 ± 0.317
4.211ThrGlu: 4.211 ± 0.318
2.449ThrPhe: 2.449 ± 0.233
5.328ThrGly: 5.328 ± 0.44
1.01ThrHis: 1.01 ± 0.154
5.006ThrIle: 5.006 ± 0.285
4.189ThrLys: 4.189 ± 0.284
5.35ThrLeu: 5.35 ± 0.336
1.332ThrMet: 1.332 ± 0.174
3.287ThrAsn: 3.287 ± 0.338
2.643ThrPro: 2.643 ± 0.319
2.041ThrGln: 2.041 ± 0.184
2.793ThrArg: 2.793 ± 0.271
3.201ThrSer: 3.201 ± 0.322
4.082ThrThr: 4.082 ± 0.393
5.457ThrVal: 5.457 ± 0.372
0.58ThrTrp: 0.58 ± 0.104
3.072ThrTyr: 3.072 ± 0.267
0.0ThrXaa: 0.0 ± 0.0
Val
4.791ValAla: 4.791 ± 0.319
0.494ValCys: 0.494 ± 0.094
4.898ValAsp: 4.898 ± 0.262
5.478ValGlu: 5.478 ± 0.397
2.514ValPhe: 2.514 ± 0.258
3.932ValGly: 3.932 ± 0.309
1.525ValHis: 1.525 ± 0.187
4.211ValIle: 4.211 ± 0.322
5.543ValLys: 5.543 ± 0.337
5.586ValLeu: 5.586 ± 0.365
1.719ValMet: 1.719 ± 0.199
3.566ValAsn: 3.566 ± 0.283
2.492ValPro: 2.492 ± 0.239
2.707ValGln: 2.707 ± 0.254
3.244ValArg: 3.244 ± 0.259
4.834ValSer: 4.834 ± 0.361
5.5ValThr: 5.5 ± 0.405
5.371ValVal: 5.371 ± 0.41
0.924ValTrp: 0.924 ± 0.142
2.986ValTyr: 2.986 ± 0.264
0.0ValXaa: 0.0 ± 0.0
Trp
0.645TrpAla: 0.645 ± 0.132
0.258TrpCys: 0.258 ± 0.062
1.053TrpAsp: 1.053 ± 0.155
0.902TrpGlu: 0.902 ± 0.132
0.473TrpPhe: 0.473 ± 0.109
0.859TrpGly: 0.859 ± 0.138
0.193TrpHis: 0.193 ± 0.066
0.687TrpIle: 0.687 ± 0.113
1.01TrpLys: 1.01 ± 0.126
0.967TrpLeu: 0.967 ± 0.134
0.215TrpMet: 0.215 ± 0.07
0.687TrpAsn: 0.687 ± 0.141
0.0TrpPro: 0.0 ± 0.0
0.473TrpGln: 0.473 ± 0.102
0.451TrpArg: 0.451 ± 0.107
0.687TrpSer: 0.687 ± 0.122
0.773TrpThr: 0.773 ± 0.125
0.752TrpVal: 0.752 ± 0.121
0.215TrpTrp: 0.215 ± 0.054
0.602TrpTyr: 0.602 ± 0.128
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.922TyrAla: 2.922 ± 0.221
0.408TyrCys: 0.408 ± 0.089
3.352TyrAsp: 3.352 ± 0.24
3.094TyrGlu: 3.094 ± 0.252
1.697TyrPhe: 1.697 ± 0.21
2.793TyrGly: 2.793 ± 0.28
0.902TyrHis: 0.902 ± 0.139
2.9TyrIle: 2.9 ± 0.269
3.437TyrLys: 3.437 ± 0.278
3.76TyrLeu: 3.76 ± 0.281
1.16TyrMet: 1.16 ± 0.13
2.406TyrAsn: 2.406 ± 0.198
0.924TyrPro: 0.924 ± 0.134
1.525TyrGln: 1.525 ± 0.166
1.654TyrArg: 1.654 ± 0.18
2.621TyrSer: 2.621 ± 0.212
3.115TyrThr: 3.115 ± 0.251
2.643TyrVal: 2.643 ± 0.249
0.559TyrTrp: 0.559 ± 0.104
2.062TyrTyr: 2.062 ± 0.242
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 229 proteins (46547 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski