Amino acid dipepetide frequency for Arthrobacter phage DrSierra

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.226AlaAla: 16.226 ± 1.503
0.381AlaCys: 0.381 ± 0.17
8.456AlaAsp: 8.456 ± 0.833
9.522AlaGlu: 9.522 ± 0.961
3.276AlaPhe: 3.276 ± 0.539
8.684AlaGly: 8.684 ± 0.924
2.514AlaHis: 2.514 ± 0.476
4.266AlaIle: 4.266 ± 0.622
6.475AlaLys: 6.475 ± 0.694
14.474AlaLeu: 14.474 ± 1.27
3.276AlaMet: 3.276 ± 0.505
2.438AlaAsn: 2.438 ± 0.412
7.161AlaPro: 7.161 ± 1.136
3.2AlaGln: 3.2 ± 0.624
8.989AlaArg: 8.989 ± 1.005
6.78AlaSer: 6.78 ± 0.769
6.094AlaThr: 6.094 ± 0.791
8.456AlaVal: 8.456 ± 0.891
2.057AlaTrp: 2.057 ± 0.302
4.19AlaTyr: 4.19 ± 0.588
0.0AlaXaa: 0.0 ± 0.0
Cys
0.533CysAla: 0.533 ± 0.21
0.0CysCys: 0.0 ± 0.0
0.533CysAsp: 0.533 ± 0.242
0.838CysGlu: 0.838 ± 0.284
0.152CysPhe: 0.152 ± 0.094
0.686CysGly: 0.686 ± 0.225
0.229CysHis: 0.229 ± 0.133
0.076CysIle: 0.076 ± 0.077
0.229CysLys: 0.229 ± 0.149
0.229CysLeu: 0.229 ± 0.182
0.0CysMet: 0.0 ± 0.0
0.381CysAsn: 0.381 ± 0.197
0.533CysPro: 0.533 ± 0.186
0.305CysGln: 0.305 ± 0.164
0.838CysArg: 0.838 ± 0.37
0.305CysSer: 0.305 ± 0.151
0.152CysThr: 0.152 ± 0.117
0.076CysVal: 0.076 ± 0.078
0.076CysTrp: 0.076 ± 0.078
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.684AspAla: 8.684 ± 0.781
0.686AspCys: 0.686 ± 0.404
4.19AspAsp: 4.19 ± 0.674
4.495AspGlu: 4.495 ± 0.58
2.362AspPhe: 2.362 ± 0.398
7.466AspGly: 7.466 ± 0.803
1.676AspHis: 1.676 ± 0.33
1.219AspIle: 1.219 ± 0.279
2.209AspLys: 2.209 ± 0.444
6.475AspLeu: 6.475 ± 1.141
0.686AspMet: 0.686 ± 0.241
1.752AspAsn: 1.752 ± 0.32
3.428AspPro: 3.428 ± 0.518
1.371AspGln: 1.371 ± 0.247
3.961AspArg: 3.961 ± 0.737
3.809AspSer: 3.809 ± 0.491
2.895AspThr: 2.895 ± 0.48
4.571AspVal: 4.571 ± 0.527
0.914AspTrp: 0.914 ± 0.216
2.133AspTyr: 2.133 ± 0.443
0.0AspXaa: 0.0 ± 0.0
Glu
10.132GluAla: 10.132 ± 1.258
0.381GluCys: 0.381 ± 0.163
3.428GluAsp: 3.428 ± 0.547
4.875GluGlu: 4.875 ± 0.62
1.676GluPhe: 1.676 ± 0.338
4.647GluGly: 4.647 ± 0.557
2.133GluHis: 2.133 ± 0.409
2.895GluIle: 2.895 ± 0.483
2.285GluLys: 2.285 ± 0.372
6.17GluLeu: 6.17 ± 0.823
1.295GluMet: 1.295 ± 0.248
1.067GluAsn: 1.067 ± 0.216
3.809GluPro: 3.809 ± 0.628
0.914GluGln: 0.914 ± 0.235
5.485GluArg: 5.485 ± 0.955
3.2GluSer: 3.2 ± 0.508
4.342GluThr: 4.342 ± 0.579
5.333GluVal: 5.333 ± 0.634
1.828GluTrp: 1.828 ± 0.376
0.99GluTyr: 0.99 ± 0.286
0.0GluXaa: 0.0 ± 0.0
Phe
2.895PheAla: 2.895 ± 0.457
0.305PheCys: 0.305 ± 0.146
2.742PheAsp: 2.742 ± 0.531
2.438PheGlu: 2.438 ± 0.437
1.295PhePhe: 1.295 ± 0.3
3.2PheGly: 3.2 ± 0.457
0.838PheHis: 0.838 ± 0.254
1.371PheIle: 1.371 ± 0.299
1.219PheLys: 1.219 ± 0.319
2.285PheLeu: 2.285 ± 0.467
0.914PheMet: 0.914 ± 0.228
0.914PheAsn: 0.914 ± 0.263
1.828PhePro: 1.828 ± 0.337
0.914PheGln: 0.914 ± 0.26
1.752PheArg: 1.752 ± 0.353
1.752PheSer: 1.752 ± 0.398
2.514PheThr: 2.514 ± 0.561
2.362PheVal: 2.362 ± 0.397
0.305PheTrp: 0.305 ± 0.173
0.914PheTyr: 0.914 ± 0.233
0.0PheXaa: 0.0 ± 0.0
Gly
8.532GlyAla: 8.532 ± 0.879
0.457GlyCys: 0.457 ± 0.192
5.18GlyAsp: 5.18 ± 0.617
6.323GlyGlu: 6.323 ± 0.698
2.742GlyPhe: 2.742 ± 0.466
6.551GlyGly: 6.551 ± 0.778
1.6GlyHis: 1.6 ± 0.306
3.733GlyIle: 3.733 ± 0.711
4.037GlyLys: 4.037 ± 0.448
7.618GlyLeu: 7.618 ± 0.907
2.285GlyMet: 2.285 ± 0.426
3.123GlyAsn: 3.123 ± 0.561
4.418GlyPro: 4.418 ± 0.664
1.6GlyGln: 1.6 ± 0.436
5.485GlyArg: 5.485 ± 0.656
3.961GlySer: 3.961 ± 0.666
5.79GlyThr: 5.79 ± 1.174
5.637GlyVal: 5.637 ± 0.713
2.438GlyTrp: 2.438 ± 0.477
3.276GlyTyr: 3.276 ± 0.545
0.0GlyXaa: 0.0 ± 0.0
His
1.828HisAla: 1.828 ± 0.377
0.229HisCys: 0.229 ± 0.115
1.371HisAsp: 1.371 ± 0.276
0.838HisGlu: 0.838 ± 0.254
1.524HisPhe: 1.524 ± 0.368
1.6HisGly: 1.6 ± 0.29
0.686HisHis: 0.686 ± 0.227
0.686HisIle: 0.686 ± 0.201
0.533HisLys: 0.533 ± 0.193
1.676HisLeu: 1.676 ± 0.397
0.381HisMet: 0.381 ± 0.157
0.609HisAsn: 0.609 ± 0.192
1.524HisPro: 1.524 ± 0.329
0.609HisGln: 0.609 ± 0.198
1.524HisArg: 1.524 ± 0.285
0.609HisSer: 0.609 ± 0.195
0.99HisThr: 0.99 ± 0.25
1.067HisVal: 1.067 ± 0.231
0.381HisTrp: 0.381 ± 0.15
0.533HisTyr: 0.533 ± 0.206
0.0HisXaa: 0.0 ± 0.0
Ile
5.028IleAla: 5.028 ± 0.499
0.229IleCys: 0.229 ± 0.129
2.362IleAsp: 2.362 ± 0.36
3.352IleGlu: 3.352 ± 0.549
1.828IlePhe: 1.828 ± 0.411
4.19IleGly: 4.19 ± 0.916
1.143IleHis: 1.143 ± 0.242
1.752IleIle: 1.752 ± 0.414
1.447IleLys: 1.447 ± 0.36
3.047IleLeu: 3.047 ± 0.552
0.838IleMet: 0.838 ± 0.249
1.067IleAsn: 1.067 ± 0.234
2.438IlePro: 2.438 ± 0.5
1.219IleGln: 1.219 ± 0.367
3.276IleArg: 3.276 ± 0.454
2.133IleSer: 2.133 ± 0.522
2.209IleThr: 2.209 ± 0.451
2.819IleVal: 2.819 ± 0.473
0.457IleTrp: 0.457 ± 0.216
0.533IleTyr: 0.533 ± 0.214
0.0IleXaa: 0.0 ± 0.0
Lys
6.247LysAla: 6.247 ± 0.717
0.152LysCys: 0.152 ± 0.111
1.904LysAsp: 1.904 ± 0.45
2.819LysGlu: 2.819 ± 0.563
1.067LysPhe: 1.067 ± 0.244
3.352LysGly: 3.352 ± 0.577
1.295LysHis: 1.295 ± 0.312
2.59LysIle: 2.59 ± 0.38
1.981LysLys: 1.981 ± 0.438
3.2LysLeu: 3.2 ± 0.502
0.838LysMet: 0.838 ± 0.262
0.99LysAsn: 0.99 ± 0.279
2.362LysPro: 2.362 ± 0.489
0.914LysGln: 0.914 ± 0.225
2.971LysArg: 2.971 ± 0.422
2.057LysSer: 2.057 ± 0.353
2.514LysThr: 2.514 ± 0.458
2.819LysVal: 2.819 ± 0.469
0.609LysTrp: 0.609 ± 0.211
0.381LysTyr: 0.381 ± 0.172
0.0LysXaa: 0.0 ± 0.0
Leu
12.95LeuAla: 12.95 ± 1.066
0.686LeuCys: 0.686 ± 0.234
6.704LeuAsp: 6.704 ± 0.902
3.961LeuGlu: 3.961 ± 0.541
2.285LeuPhe: 2.285 ± 0.376
7.313LeuGly: 7.313 ± 0.846
1.143LeuHis: 1.143 ± 0.373
4.418LeuIle: 4.418 ± 0.587
2.209LeuLys: 2.209 ± 0.417
6.704LeuLeu: 6.704 ± 0.625
1.143LeuMet: 1.143 ± 0.281
2.819LeuAsn: 2.819 ± 0.472
4.647LeuPro: 4.647 ± 0.599
2.59LeuGln: 2.59 ± 0.536
7.618LeuArg: 7.618 ± 0.849
5.18LeuSer: 5.18 ± 0.769
6.932LeuThr: 6.932 ± 0.58
5.942LeuVal: 5.942 ± 0.667
1.447LeuTrp: 1.447 ± 0.263
1.6LeuTyr: 1.6 ± 0.42
0.0LeuXaa: 0.0 ± 0.0
Met
3.276MetAla: 3.276 ± 0.493
0.152MetCys: 0.152 ± 0.109
1.295MetAsp: 1.295 ± 0.325
1.143MetGlu: 1.143 ± 0.279
0.381MetPhe: 0.381 ± 0.159
1.143MetGly: 1.143 ± 0.362
0.229MetHis: 0.229 ± 0.136
1.371MetIle: 1.371 ± 0.321
1.143MetLys: 1.143 ± 0.254
1.371MetLeu: 1.371 ± 0.269
0.229MetMet: 0.229 ± 0.128
0.305MetAsn: 0.305 ± 0.153
0.838MetPro: 0.838 ± 0.241
0.305MetGln: 0.305 ± 0.143
0.914MetArg: 0.914 ± 0.277
1.371MetSer: 1.371 ± 0.336
2.285MetThr: 2.285 ± 0.477
0.838MetVal: 0.838 ± 0.225
0.0MetTrp: 0.0 ± 0.0
0.229MetTyr: 0.229 ± 0.115
0.0MetXaa: 0.0 ± 0.0
Asn
4.037AsnAla: 4.037 ± 0.666
0.0AsnCys: 0.0 ± 0.0
1.904AsnAsp: 1.904 ± 0.425
0.686AsnGlu: 0.686 ± 0.202
0.533AsnPhe: 0.533 ± 0.188
2.971AsnGly: 2.971 ± 0.559
0.381AsnHis: 0.381 ± 0.155
0.914AsnIle: 0.914 ± 0.255
0.609AsnLys: 0.609 ± 0.158
1.828AsnLeu: 1.828 ± 0.373
0.533AsnMet: 0.533 ± 0.194
0.305AsnAsn: 0.305 ± 0.243
2.514AsnPro: 2.514 ± 0.457
0.533AsnGln: 0.533 ± 0.196
1.752AsnArg: 1.752 ± 0.357
1.295AsnSer: 1.295 ± 0.213
2.362AsnThr: 2.362 ± 0.531
2.362AsnVal: 2.362 ± 0.562
0.381AsnTrp: 0.381 ± 0.193
0.686AsnTyr: 0.686 ± 0.26
0.0AsnXaa: 0.0 ± 0.0
Pro
8.151ProAla: 8.151 ± 1.288
0.533ProCys: 0.533 ± 0.199
4.571ProAsp: 4.571 ± 0.513
4.571ProGlu: 4.571 ± 0.518
2.209ProPhe: 2.209 ± 0.32
5.485ProGly: 5.485 ± 0.808
0.99ProHis: 0.99 ± 0.231
2.133ProIle: 2.133 ± 0.425
2.819ProLys: 2.819 ± 0.483
4.266ProLeu: 4.266 ± 0.646
0.914ProMet: 0.914 ± 0.231
1.067ProAsn: 1.067 ± 0.261
2.133ProPro: 2.133 ± 0.576
0.838ProGln: 0.838 ± 0.312
3.2ProArg: 3.2 ± 0.424
2.285ProSer: 2.285 ± 0.402
2.819ProThr: 2.819 ± 0.523
4.266ProVal: 4.266 ± 0.59
0.762ProTrp: 0.762 ± 0.233
0.762ProTyr: 0.762 ± 0.233
0.0ProXaa: 0.0 ± 0.0
Gln
2.285GlnAla: 2.285 ± 0.38
0.381GlnCys: 0.381 ± 0.163
1.371GlnAsp: 1.371 ± 0.313
1.143GlnGlu: 1.143 ± 0.25
0.457GlnPhe: 0.457 ± 0.184
1.295GlnGly: 1.295 ± 0.459
0.381GlnHis: 0.381 ± 0.167
1.143GlnIle: 1.143 ± 0.331
1.676GlnLys: 1.676 ± 0.345
1.524GlnLeu: 1.524 ± 0.332
1.067GlnMet: 1.067 ± 0.453
0.99GlnAsn: 0.99 ± 0.233
0.686GlnPro: 0.686 ± 0.223
0.305GlnGln: 0.305 ± 0.128
1.828GlnArg: 1.828 ± 0.457
1.295GlnSer: 1.295 ± 0.324
1.904GlnThr: 1.904 ± 0.424
2.133GlnVal: 2.133 ± 0.451
0.457GlnTrp: 0.457 ± 0.19
0.305GlnTyr: 0.305 ± 0.125
0.0GlnXaa: 0.0 ± 0.0
Arg
7.846ArgAla: 7.846 ± 0.884
0.381ArgCys: 0.381 ± 0.167
5.561ArgAsp: 5.561 ± 0.918
5.409ArgGlu: 5.409 ± 0.679
3.047ArgPhe: 3.047 ± 0.399
4.875ArgGly: 4.875 ± 0.68
1.143ArgHis: 1.143 ± 0.339
2.742ArgIle: 2.742 ± 0.617
3.352ArgLys: 3.352 ± 0.514
7.389ArgLeu: 7.389 ± 0.93
1.295ArgMet: 1.295 ± 0.339
2.362ArgAsn: 2.362 ± 0.475
3.047ArgPro: 3.047 ± 0.424
2.285ArgGln: 2.285 ± 0.422
6.323ArgArg: 6.323 ± 0.995
3.809ArgSer: 3.809 ± 0.586
3.428ArgThr: 3.428 ± 0.596
5.942ArgVal: 5.942 ± 0.745
1.143ArgTrp: 1.143 ± 0.267
2.285ArgTyr: 2.285 ± 0.516
0.0ArgXaa: 0.0 ± 0.0
Ser
5.485SerAla: 5.485 ± 0.639
0.076SerCys: 0.076 ± 0.081
2.59SerAsp: 2.59 ± 0.453
3.504SerGlu: 3.504 ± 0.41
2.285SerPhe: 2.285 ± 0.444
6.399SerGly: 6.399 ± 0.859
0.533SerHis: 0.533 ± 0.193
2.666SerIle: 2.666 ± 0.458
2.057SerLys: 2.057 ± 0.412
3.428SerLeu: 3.428 ± 0.606
0.762SerMet: 0.762 ± 0.263
1.752SerAsn: 1.752 ± 0.335
2.819SerPro: 2.819 ± 0.402
1.143SerGln: 1.143 ± 0.315
3.2SerArg: 3.2 ± 0.372
2.895SerSer: 2.895 ± 0.401
4.495SerThr: 4.495 ± 0.508
4.114SerVal: 4.114 ± 0.59
1.143SerTrp: 1.143 ± 0.288
1.752SerTyr: 1.752 ± 0.363
0.0SerXaa: 0.0 ± 0.0
Thr
7.77ThrAla: 7.77 ± 0.821
0.457ThrCys: 0.457 ± 0.241
3.276ThrAsp: 3.276 ± 0.41
3.961ThrGlu: 3.961 ± 0.637
2.59ThrPhe: 2.59 ± 0.471
6.551ThrGly: 6.551 ± 0.789
0.609ThrHis: 0.609 ± 0.21
2.438ThrIle: 2.438 ± 0.449
2.057ThrLys: 2.057 ± 0.323
5.942ThrLeu: 5.942 ± 0.675
0.457ThrMet: 0.457 ± 0.205
1.295ThrAsn: 1.295 ± 0.271
4.799ThrPro: 4.799 ± 0.773
0.99ThrGln: 0.99 ± 0.275
4.647ThrArg: 4.647 ± 0.653
3.657ThrSer: 3.657 ± 0.52
4.571ThrThr: 4.571 ± 0.861
5.028ThrVal: 5.028 ± 0.928
0.914ThrTrp: 0.914 ± 0.305
1.447ThrTyr: 1.447 ± 0.363
0.0ThrXaa: 0.0 ± 0.0
Val
9.675ValAla: 9.675 ± 0.926
0.533ValCys: 0.533 ± 0.203
4.19ValAsp: 4.19 ± 0.74
4.19ValGlu: 4.19 ± 0.766
1.676ValPhe: 1.676 ± 0.332
4.571ValGly: 4.571 ± 0.736
0.914ValHis: 0.914 ± 0.296
3.123ValIle: 3.123 ± 0.491
2.971ValLys: 2.971 ± 0.575
6.932ValLeu: 6.932 ± 0.661
1.067ValMet: 1.067 ± 0.258
1.981ValAsn: 1.981 ± 0.413
3.961ValPro: 3.961 ± 0.358
1.828ValGln: 1.828 ± 0.394
6.551ValArg: 6.551 ± 0.935
4.266ValSer: 4.266 ± 0.552
3.961ValThr: 3.961 ± 0.4
5.637ValVal: 5.637 ± 0.699
1.295ValTrp: 1.295 ± 0.346
2.59ValTyr: 2.59 ± 0.393
0.0ValXaa: 0.0 ± 0.0
Trp
1.981TrpAla: 1.981 ± 0.32
0.0TrpCys: 0.0 ± 0.0
1.447TrpAsp: 1.447 ± 0.327
1.371TrpGlu: 1.371 ± 0.311
0.229TrpPhe: 0.229 ± 0.128
1.295TrpGly: 1.295 ± 0.277
0.381TrpHis: 0.381 ± 0.153
0.99TrpIle: 0.99 ± 0.283
0.609TrpLys: 0.609 ± 0.213
1.6TrpLeu: 1.6 ± 0.367
0.305TrpMet: 0.305 ± 0.124
0.762TrpAsn: 0.762 ± 0.238
0.381TrpPro: 0.381 ± 0.189
0.457TrpGln: 0.457 ± 0.224
1.6TrpArg: 1.6 ± 0.34
1.295TrpSer: 1.295 ± 0.313
1.6TrpThr: 1.6 ± 0.353
0.609TrpVal: 0.609 ± 0.207
0.152TrpTrp: 0.152 ± 0.134
0.305TrpTyr: 0.305 ± 0.147
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.428TyrAla: 3.428 ± 0.443
0.152TyrCys: 0.152 ± 0.121
1.904TyrAsp: 1.904 ± 0.475
1.447TyrGlu: 1.447 ± 0.307
1.143TyrPhe: 1.143 ± 0.29
2.514TyrGly: 2.514 ± 0.405
0.381TyrHis: 0.381 ± 0.165
0.838TyrIle: 0.838 ± 0.261
1.143TyrLys: 1.143 ± 0.3
2.133TyrLeu: 2.133 ± 0.367
0.457TyrMet: 0.457 ± 0.209
0.609TyrAsn: 0.609 ± 0.236
1.447TyrPro: 1.447 ± 0.327
0.305TyrGln: 0.305 ± 0.128
1.752TyrArg: 1.752 ± 0.34
1.143TyrSer: 1.143 ± 0.294
1.6TyrThr: 1.6 ± 0.341
1.904TyrVal: 1.904 ± 0.42
0.609TyrTrp: 0.609 ± 0.21
0.381TyrTyr: 0.381 ± 0.181
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 66 proteins (13128 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski