Amino acid dipepetide frequency for Sphingomonas taxi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.501AlaAla: 23.501 ± 0.239	1.038AlaCys: 1.038 ± 0.029	8.475AlaAsp: 8.475 ± 0.102	7.307AlaGlu: 7.307 ± 0.102	4.41AlaPhe: 4.41 ± 0.059	12.947AlaGly: 12.947 ± 0.12	2.392AlaHis: 2.392 ± 0.058	7.102AlaIle: 7.102 ± 0.082	3.865AlaLys: 3.865 ± 0.073	14.682AlaLeu: 14.682 ± 0.144	3.844AlaMet: 3.844 ± 0.068	3.221AlaAsn: 3.221 ± 0.068	7.208AlaPro: 7.208 ± 0.113	4.674AlaGln: 4.674 ± 0.068	10.67AlaArg: 10.67 ± 0.117	6.437AlaSer: 6.437 ± 0.083	8.332AlaThr: 8.332 ± 0.117	9.721AlaVal: 9.721 ± 0.107	1.798AlaTrp: 1.798 ± 0.043	2.739AlaTyr: 2.739 ± 0.054	0.0AlaXaa: 0.0 ± 0.0
Cys	0.873CysAla: 0.873 ± 0.028	0.084CysCys: 0.084 ± 0.01	0.461CysAsp: 0.461 ± 0.023	0.305CysGlu: 0.305 ± 0.018	0.25CysPhe: 0.25 ± 0.018	0.727CysGly: 0.727 ± 0.029	0.162CysHis: 0.162 ± 0.013	0.297CysIle: 0.297 ± 0.015	0.121CysLys: 0.121 ± 0.01	0.574CysLeu: 0.574 ± 0.024	0.111CysMet: 0.111 ± 0.01	0.159CysAsn: 0.159 ± 0.013	0.394CysPro: 0.394 ± 0.021	0.157CysGln: 0.157 ± 0.012	0.498CysArg: 0.498 ± 0.02	0.351CysSer: 0.351 ± 0.019	0.375CysThr: 0.375 ± 0.017	0.503CysVal: 0.503 ± 0.02	0.094CysTrp: 0.094 ± 0.009	0.153CysTyr: 0.153 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	8.924AspAla: 8.924 ± 0.104	0.391AspCys: 0.391 ± 0.021	3.569AspAsp: 3.569 ± 0.066	3.017AspGlu: 3.017 ± 0.064	2.004AspPhe: 2.004 ± 0.047	6.27AspGly: 6.27 ± 0.09	1.432AspHis: 1.432 ± 0.039	2.583AspIle: 2.583 ± 0.045	1.46AspLys: 1.46 ± 0.046	5.962AspLeu: 5.962 ± 0.082	1.195AspMet: 1.195 ± 0.033	1.182AspAsn: 1.182 ± 0.034	4.022AspPro: 4.022 ± 0.06	1.862AspGln: 1.862 ± 0.039	5.329AspArg: 5.329 ± 0.076	2.086AspSer: 2.086 ± 0.043	3.007AspThr: 3.007 ± 0.05	4.424AspVal: 4.424 ± 0.067	1.19AspTrp: 1.19 ± 0.034	1.751AspTyr: 1.751 ± 0.04	0.0AspXaa: 0.0 ± 0.0
Glu	7.321GluAla: 7.321 ± 0.104	0.223GluCys: 0.223 ± 0.016	2.348GluAsp: 2.348 ± 0.05	2.321GluGlu: 2.321 ± 0.064	1.132GluPhe: 1.132 ± 0.029	3.978GluGly: 3.978 ± 0.068	1.003GluHis: 1.003 ± 0.03	2.384GluIle: 2.384 ± 0.052	1.359GluLys: 1.359 ± 0.042	4.276GluLeu: 4.276 ± 0.078	1.098GluMet: 1.098 ± 0.035	0.99GluAsn: 0.99 ± 0.033	2.352GluPro: 2.352 ± 0.049	1.783GluGln: 1.783 ± 0.042	4.706GluArg: 4.706 ± 0.077	1.875GluSer: 1.875 ± 0.047	3.034GluThr: 3.034 ± 0.058	3.309GluVal: 3.309 ± 0.061	0.602GluTrp: 0.602 ± 0.025	0.789GluTyr: 0.789 ± 0.028	0.0GluXaa: 0.0 ± 0.0
Phe	5.08PheAla: 5.08 ± 0.081	0.262PheCys: 0.262 ± 0.015	2.677PheAsp: 2.677 ± 0.054	1.674PheGlu: 1.674 ± 0.044	1.153PhePhe: 1.153 ± 0.035	3.642PheGly: 3.642 ± 0.065	0.673PheHis: 0.673 ± 0.025	1.129PheIle: 1.129 ± 0.034	0.739PheLys: 0.739 ± 0.028	2.855PheLeu: 2.855 ± 0.061	0.639PheMet: 0.639 ± 0.022	0.958PheAsn: 0.958 ± 0.032	1.391PhePro: 1.391 ± 0.034	0.86PheGln: 0.86 ± 0.032	2.224PheArg: 2.224 ± 0.052	1.613PheSer: 1.613 ± 0.045	2.089PheThr: 2.089 ± 0.052	2.751PheVal: 2.751 ± 0.05	0.464PheTrp: 0.464 ± 0.02	0.885PheTyr: 0.885 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.975GlyAla: 10.975 ± 0.114	0.754GlyCys: 0.754 ± 0.027	5.328GlyAsp: 5.328 ± 0.08	4.616GlyGlu: 4.616 ± 0.073	3.71GlyPhe: 3.71 ± 0.064	8.614GlyGly: 8.614 ± 0.126	1.928GlyHis: 1.928 ± 0.049	4.585GlyIle: 4.585 ± 0.07	2.88GlyLys: 2.88 ± 0.059	8.815GlyLeu: 8.815 ± 0.093	2.174GlyMet: 2.174 ± 0.057	2.284GlyAsn: 2.284 ± 0.057	3.59GlyPro: 3.59 ± 0.052	2.943GlyGln: 2.943 ± 0.056	7.053GlyArg: 7.053 ± 0.079	4.725GlySer: 4.725 ± 0.07	5.38GlyThr: 5.38 ± 0.103	6.798GlyVal: 6.798 ± 0.068	1.783GlyTrp: 1.783 ± 0.045	2.566GlyTyr: 2.566 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.682HisAla: 2.682 ± 0.061	0.181HisCys: 0.181 ± 0.012	1.352HisAsp: 1.352 ± 0.034	0.898HisGlu: 0.898 ± 0.029	0.734HisPhe: 0.734 ± 0.026	2.076HisGly: 2.076 ± 0.047	0.578HisHis: 0.578 ± 0.024	0.768HisIle: 0.768 ± 0.029	0.341HisLys: 0.341 ± 0.019	1.904HisLeu: 1.904 ± 0.043	0.374HisMet: 0.374 ± 0.019	0.412HisAsn: 0.412 ± 0.02	1.298HisPro: 1.298 ± 0.037	0.531HisGln: 0.531 ± 0.022	1.569HisArg: 1.569 ± 0.041	0.756HisSer: 0.756 ± 0.023	0.686HisThr: 0.686 ± 0.024	1.513HisVal: 1.513 ± 0.04	0.389HisTrp: 0.389 ± 0.02	0.561HisTyr: 0.561 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	8.239IleAla: 8.239 ± 0.088	0.328IleCys: 0.328 ± 0.016	3.987IleAsp: 3.987 ± 0.065	2.964IleGlu: 2.964 ± 0.058	1.231IlePhe: 1.231 ± 0.036	5.284IleGly: 5.284 ± 0.08	0.847IleHis: 0.847 ± 0.028	1.549IleIle: 1.549 ± 0.044	1.064IleLys: 1.064 ± 0.032	3.633IleLeu: 3.633 ± 0.068	0.69IleMet: 0.69 ± 0.026	1.198IleAsn: 1.198 ± 0.044	2.067IlePro: 2.067 ± 0.045	1.06IleGln: 1.06 ± 0.034	3.118IleArg: 3.118 ± 0.051	1.868IleSer: 1.868 ± 0.047	2.455IleThr: 2.455 ± 0.057	4.402IleVal: 4.402 ± 0.069	0.532IleTrp: 0.532 ± 0.023	0.815IleTyr: 0.815 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.555LysAla: 3.555 ± 0.068	0.085LysCys: 0.085 ± 0.009	1.315LysAsp: 1.315 ± 0.036	0.862LysGlu: 0.862 ± 0.033	0.687LysPhe: 0.687 ± 0.028	2.308LysGly: 2.308 ± 0.055	0.41LysHis: 0.41 ± 0.021	1.116LysIle: 1.116 ± 0.038	0.769LysLys: 0.769 ± 0.035	2.666LysLeu: 2.666 ± 0.049	0.612LysMet: 0.612 ± 0.027	0.597LysAsn: 0.597 ± 0.028	1.853LysPro: 1.853 ± 0.051	0.792LysGln: 0.792 ± 0.028	1.978LysArg: 1.978 ± 0.047	1.227LysSer: 1.227 ± 0.036	1.63LysThr: 1.63 ± 0.044	1.977LysVal: 1.977 ± 0.05	0.296LysTrp: 0.296 ± 0.016	0.503LysTyr: 0.503 ± 0.027	0.0LysXaa: 0.0 ± 0.0
Leu	15.301LeuAla: 15.301 ± 0.166	0.669LeuCys: 0.669 ± 0.023	6.503LeuAsp: 6.503 ± 0.083	3.843LeuGlu: 3.843 ± 0.071	3.58LeuPhe: 3.58 ± 0.064	8.532LeuGly: 8.532 ± 0.088	1.816LeuHis: 1.816 ± 0.049	4.551LeuIle: 4.551 ± 0.075	2.523LeuLys: 2.523 ± 0.053	9.392LeuLeu: 9.392 ± 0.155	1.867LeuMet: 1.867 ± 0.052	2.227LeuAsn: 2.227 ± 0.044	5.926LeuPro: 5.926 ± 0.085	2.319LeuGln: 2.319 ± 0.046	7.017LeuArg: 7.017 ± 0.089	5.433LeuSer: 5.433 ± 0.077	5.894LeuThr: 5.894 ± 0.071	7.505LeuVal: 7.505 ± 0.087	1.256LeuTrp: 1.256 ± 0.04	2.043LeuTyr: 2.043 ± 0.046	0.0LeuXaa: 0.0 ± 0.0
Met	3.001MetAla: 3.001 ± 0.058	0.119MetCys: 0.119 ± 0.009	0.945MetAsp: 0.945 ± 0.029	0.811MetGlu: 0.811 ± 0.031	0.624MetPhe: 0.624 ± 0.024	1.604MetGly: 1.604 ± 0.042	0.402MetHis: 0.402 ± 0.02	1.285MetIle: 1.285 ± 0.035	0.719MetLys: 0.719 ± 0.029	2.496MetLeu: 2.496 ± 0.052	0.585MetMet: 0.585 ± 0.03	0.524MetAsn: 0.524 ± 0.022	1.385MetPro: 1.385 ± 0.039	0.608MetGln: 0.608 ± 0.024	1.728MetArg: 1.728 ± 0.046	1.173MetSer: 1.173 ± 0.033	1.82MetThr: 1.82 ± 0.041	1.452MetVal: 1.452 ± 0.038	0.195MetTrp: 0.195 ± 0.014	0.255MetTyr: 0.255 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.164AsnAla: 3.164 ± 0.066	0.191AsnCys: 0.191 ± 0.013	1.395AsnAsp: 1.395 ± 0.038	0.881AsnGlu: 0.881 ± 0.03	0.873AsnPhe: 0.873 ± 0.038	2.421AsnGly: 2.421 ± 0.064	0.433AsnHis: 0.433 ± 0.017	1.144AsnIle: 1.144 ± 0.042	0.524AsnLys: 0.524 ± 0.024	2.354AsnLeu: 2.354 ± 0.051	0.44AsnMet: 0.44 ± 0.02	0.653AsnAsn: 0.653 ± 0.037	1.63AsnPro: 1.63 ± 0.043	0.719AsnGln: 0.719 ± 0.028	1.731AsnArg: 1.731 ± 0.036	1.085AsnSer: 1.085 ± 0.04	1.221AsnThr: 1.221 ± 0.04	1.897AsnVal: 1.897 ± 0.051	0.389AsnTrp: 0.389 ± 0.021	0.746AsnTyr: 0.746 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	8.436ProAla: 8.436 ± 0.104	0.286ProCys: 0.286 ± 0.017	3.947ProAsp: 3.947 ± 0.064	2.994ProGlu: 2.994 ± 0.06	1.885ProPhe: 1.885 ± 0.039	4.956ProGly: 4.956 ± 0.07	1.06ProHis: 1.06 ± 0.031	2.409ProIle: 2.409 ± 0.046	1.328ProLys: 1.328 ± 0.036	5.197ProLeu: 5.197 ± 0.074	1.121ProMet: 1.121 ± 0.031	1.217ProAsn: 1.217 ± 0.038	2.892ProPro: 2.892 ± 0.078	1.771ProGln: 1.771 ± 0.042	3.337ProArg: 3.337 ± 0.064	2.514ProSer: 2.514 ± 0.051	2.976ProThr: 2.976 ± 0.06	4.585ProVal: 4.585 ± 0.08	0.695ProTrp: 0.695 ± 0.027	1.141ProTyr: 1.141 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.431GlnAla: 4.431 ± 0.077	0.169GlnCys: 0.169 ± 0.013	1.377GlnAsp: 1.377 ± 0.038	1.033GlnGlu: 1.033 ± 0.031	0.997GlnPhe: 0.997 ± 0.036	2.431GlnGly: 2.431 ± 0.048	0.576GlnHis: 0.576 ± 0.021	1.574GlnIle: 1.574 ± 0.04	0.695GlnLys: 0.695 ± 0.026	2.997GlnLeu: 2.997 ± 0.051	0.741GlnMet: 0.741 ± 0.029	0.743GlnAsn: 0.743 ± 0.032	1.949GlnPro: 1.949 ± 0.046	1.257GlnGln: 1.257 ± 0.043	2.59GlnArg: 2.59 ± 0.055	1.591GlnSer: 1.591 ± 0.042	1.839GlnThr: 1.839 ± 0.042	2.353GlnVal: 2.353 ± 0.047	0.417GlnTrp: 0.417 ± 0.02	0.637GlnTyr: 0.637 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.458ArgAla: 9.458 ± 0.109	0.46ArgCys: 0.46 ± 0.02	4.893ArgAsp: 4.893 ± 0.075	3.57ArgGlu: 3.57 ± 0.064	3.205ArgPhe: 3.205 ± 0.051	5.628ArgGly: 5.628 ± 0.078	1.771ArgHis: 1.771 ± 0.044	4.233ArgIle: 4.233 ± 0.06	1.709ArgLys: 1.709 ± 0.045	8.593ArgLeu: 8.593 ± 0.116	1.896ArgMet: 1.896 ± 0.045	1.769ArgAsn: 1.769 ± 0.044	4.071ArgPro: 4.071 ± 0.064	2.519ArgGln: 2.519 ± 0.052	6.309ArgArg: 6.309 ± 0.1	3.658ArgSer: 3.658 ± 0.057	3.992ArgThr: 3.992 ± 0.067	5.296ArgVal: 5.296 ± 0.07	1.298ArgTrp: 1.298 ± 0.041	2.041ArgTyr: 2.041 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	6.07SerAla: 6.07 ± 0.081	0.306SerCys: 0.306 ± 0.017	2.862SerAsp: 2.862 ± 0.056	1.939SerGlu: 1.939 ± 0.04	1.849SerPhe: 1.849 ± 0.04	5.053SerGly: 5.053 ± 0.076	0.875SerHis: 0.875 ± 0.025	2.364SerIle: 2.364 ± 0.043	1.146SerLys: 1.146 ± 0.033	4.62SerLeu: 4.62 ± 0.067	0.915SerMet: 0.915 ± 0.029	1.337SerAsn: 1.337 ± 0.036	2.711SerPro: 2.711 ± 0.056	1.34SerGln: 1.34 ± 0.037	3.245SerArg: 3.245 ± 0.053	2.396SerSer: 2.396 ± 0.054	2.67SerThr: 2.67 ± 0.053	3.537SerVal: 3.537 ± 0.065	0.719SerTrp: 0.719 ± 0.026	1.394SerTyr: 1.394 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	7.44ThrAla: 7.44 ± 0.115	0.324ThrCys: 0.324 ± 0.017	3.153ThrAsp: 3.153 ± 0.053	2.193ThrGlu: 2.193 ± 0.045	1.816ThrPhe: 1.816 ± 0.043	5.916ThrGly: 5.916 ± 0.094	0.97ThrHis: 0.97 ± 0.028	3.345ThrIle: 3.345 ± 0.061	1.291ThrLys: 1.291 ± 0.037	6.606ThrLeu: 6.606 ± 0.085	1.191ThrMet: 1.191 ± 0.03	1.34ThrAsn: 1.34 ± 0.048	4.009ThrPro: 4.009 ± 0.07	1.708ThrGln: 1.708 ± 0.037	3.993ThrArg: 3.993 ± 0.061	2.688ThrSer: 2.688 ± 0.052	3.248ThrThr: 3.248 ± 0.073	4.767ThrVal: 4.767 ± 0.104	0.635ThrTrp: 0.635 ± 0.026	1.303ThrTyr: 1.303 ± 0.039	0.0ThrXaa: 0.0 ± 0.0
Val	11.517ValAla: 11.517 ± 0.126	0.471ValCys: 0.471 ± 0.021	4.677ValAsp: 4.677 ± 0.065	4.081ValGlu: 4.081 ± 0.065	2.223ValPhe: 2.223 ± 0.053	5.885ValGly: 5.885 ± 0.08	1.407ValHis: 1.407 ± 0.038	3.559ValIle: 3.559 ± 0.058	1.803ValLys: 1.803 ± 0.044	6.742ValLeu: 6.742 ± 0.086	1.529ValMet: 1.529 ± 0.044	1.981ValAsn: 1.981 ± 0.057	4.187ValPro: 4.187 ± 0.057	2.131ValGln: 2.131 ± 0.049	5.655ValArg: 5.655 ± 0.068	3.907ValSer: 3.907 ± 0.064	5.217ValThr: 5.217 ± 0.101	6.031ValVal: 6.031 ± 0.098	0.859ValTrp: 0.859 ± 0.029	1.493ValTyr: 1.493 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.392TrpAla: 1.392 ± 0.037	0.116TrpCys: 0.116 ± 0.01	0.726TrpAsp: 0.726 ± 0.027	0.502TrpGlu: 0.502 ± 0.021	0.573TrpPhe: 0.573 ± 0.025	0.976TrpGly: 0.976 ± 0.03	0.366TrpHis: 0.366 ± 0.017	0.601TrpIle: 0.601 ± 0.024	0.36TrpLys: 0.36 ± 0.02	1.731TrpLeu: 1.731 ± 0.051	0.328TrpMet: 0.328 ± 0.019	0.41TrpAsn: 0.41 ± 0.02	0.751TrpPro: 0.751 ± 0.027	0.671TrpGln: 0.671 ± 0.024	1.508TrpArg: 1.508 ± 0.04	0.857TrpSer: 0.857 ± 0.03	0.964TrpThr: 0.964 ± 0.032	0.815TrpVal: 0.815 ± 0.027	0.293TrpTrp: 0.293 ± 0.019	0.318TrpTyr: 0.318 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.005TyrAla: 3.005 ± 0.06	0.194TyrCys: 0.194 ± 0.013	1.669TyrAsp: 1.669 ± 0.047	1.072TyrGlu: 1.072 ± 0.029	0.822TyrPhe: 0.822 ± 0.026	2.253TyrGly: 2.253 ± 0.055	0.502TyrHis: 0.502 ± 0.021	0.751TyrIle: 0.751 ± 0.025	0.541TyrLys: 0.541 ± 0.023	2.102TyrLeu: 2.102 ± 0.04	0.379TyrMet: 0.379 ± 0.017	0.686TyrAsn: 0.686 ± 0.032	1.061TyrPro: 1.061 ± 0.031	0.695TyrGln: 0.695 ± 0.025	2.11TyrArg: 2.11 ± 0.047	1.109TyrSer: 1.109 ± 0.032	1.107TyrThr: 1.107 ± 0.038	1.718TyrVal: 1.718 ± 0.041	0.355TyrTrp: 0.355 ± 0.021	0.66TyrTyr: 0.66 ± 0.026	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3401 proteins (1123099 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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