Amino acid dipepetide frequency for Plantibacter sp. Leaf314

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.224AlaAla: 20.224 ± 0.218	0.632AlaCys: 0.632 ± 0.025	8.299AlaAsp: 8.299 ± 0.161	8.161AlaGlu: 8.161 ± 0.091	4.108AlaPhe: 4.108 ± 0.061	12.005AlaGly: 12.005 ± 0.107	2.187AlaHis: 2.187 ± 0.046	5.979AlaIle: 5.979 ± 0.077	2.762AlaLys: 2.762 ± 0.058	13.604AlaLeu: 13.604 ± 0.128	2.619AlaMet: 2.619 ± 0.051	2.326AlaAsn: 2.326 ± 0.05	6.167AlaPro: 6.167 ± 0.094	3.491AlaGln: 3.491 ± 0.061	8.308AlaArg: 8.308 ± 0.091	7.678AlaSer: 7.678 ± 0.085	8.101AlaThr: 8.101 ± 0.096	12.114AlaVal: 12.114 ± 0.117	1.888AlaTrp: 1.888 ± 0.044	2.304AlaTyr: 2.304 ± 0.047	0.001AlaXaa: 0.001 ± 0.001
Cys	0.599CysAla: 0.599 ± 0.025	0.05CysCys: 0.05 ± 0.007	0.283CysAsp: 0.283 ± 0.014	0.226CysGlu: 0.226 ± 0.015	0.174CysPhe: 0.174 ± 0.014	0.523CysGly: 0.523 ± 0.022	0.11CysHis: 0.11 ± 0.011	0.183CysIle: 0.183 ± 0.013	0.058CysLys: 0.058 ± 0.008	0.399CysLeu: 0.399 ± 0.02	0.071CysMet: 0.071 ± 0.008	0.088CysAsn: 0.088 ± 0.01	0.253CysPro: 0.253 ± 0.018	0.103CysGln: 0.103 ± 0.01	0.282CysArg: 0.282 ± 0.019	0.344CysSer: 0.344 ± 0.018	0.307CysThr: 0.307 ± 0.017	0.371CysVal: 0.371 ± 0.017	0.066CysTrp: 0.066 ± 0.008	0.093CysTyr: 0.093 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	9.131AspAla: 9.131 ± 0.144	0.223AspCys: 0.223 ± 0.014	4.598AspAsp: 4.598 ± 0.068	4.41AspGlu: 4.41 ± 0.068	1.694AspPhe: 1.694 ± 0.039	6.376AspGly: 6.376 ± 0.086	1.364AspHis: 1.364 ± 0.037	2.22AspIle: 2.22 ± 0.047	0.853AspLys: 0.853 ± 0.034	6.173AspLeu: 6.173 ± 0.076	0.655AspMet: 0.655 ± 0.025	0.878AspAsn: 0.878 ± 0.024	4.233AspPro: 4.233 ± 0.072	1.686AspGln: 1.686 ± 0.036	4.82AspArg: 4.82 ± 0.072	2.529AspSer: 2.529 ± 0.052	3.285AspThr: 3.285 ± 0.084	5.527AspVal: 5.527 ± 0.096	1.026AspTrp: 1.026 ± 0.03	1.219AspTyr: 1.219 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	7.265GluAla: 7.265 ± 0.094	0.196GluCys: 0.196 ± 0.014	2.765GluAsp: 2.765 ± 0.052	2.965GluGlu: 2.965 ± 0.051	1.58GluPhe: 1.58 ± 0.041	3.579GluGly: 3.579 ± 0.059	1.72GluHis: 1.72 ± 0.043	2.466GluIle: 2.466 ± 0.047	0.875GluLys: 0.875 ± 0.032	7.191GluLeu: 7.191 ± 0.082	0.83GluMet: 0.83 ± 0.025	0.974GluAsn: 0.974 ± 0.029	3.179GluPro: 3.179 ± 0.052	2.614GluGln: 2.614 ± 0.049	5.716GluArg: 5.716 ± 0.08	2.865GluSer: 2.865 ± 0.047	3.126GluThr: 3.126 ± 0.063	4.572GluVal: 4.572 ± 0.064	0.786GluTrp: 0.786 ± 0.025	1.117GluTyr: 1.117 ± 0.031	0.0GluXaa: 0.0 ± 0.0
Phe	4.223PheAla: 4.223 ± 0.068	0.16PheCys: 0.16 ± 0.012	2.397PheAsp: 2.397 ± 0.045	1.711PheGlu: 1.711 ± 0.04	1.079PhePhe: 1.079 ± 0.038	3.544PheGly: 3.544 ± 0.069	0.534PheHis: 0.534 ± 0.023	1.344PheIle: 1.344 ± 0.039	0.43PheLys: 0.43 ± 0.018	2.939PheLeu: 2.939 ± 0.055	0.47PheMet: 0.47 ± 0.02	0.625PheAsn: 0.625 ± 0.028	1.478PhePro: 1.478 ± 0.039	0.787PheGln: 0.787 ± 0.029	1.881PheArg: 1.881 ± 0.046	1.899PheSer: 1.899 ± 0.041	2.209PheThr: 2.209 ± 0.053	2.942PheVal: 2.942 ± 0.059	0.479PheTrp: 0.479 ± 0.024	0.61PheTyr: 0.61 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.566GlyAla: 10.566 ± 0.109	0.547GlyCys: 0.547 ± 0.023	4.926GlyAsp: 4.926 ± 0.067	4.632GlyGlu: 4.632 ± 0.073	3.434GlyPhe: 3.434 ± 0.058	7.784GlyGly: 7.784 ± 0.12	1.76GlyHis: 1.76 ± 0.042	4.505GlyIle: 4.505 ± 0.066	2.023GlyLys: 2.023 ± 0.053	9.073GlyLeu: 9.073 ± 0.112	1.738GlyMet: 1.738 ± 0.043	1.654GlyAsn: 1.654 ± 0.038	3.936GlyPro: 3.936 ± 0.061	2.5GlyGln: 2.5 ± 0.059	6.376GlyArg: 6.376 ± 0.085	5.925GlySer: 5.925 ± 0.071	5.924GlyThr: 5.924 ± 0.09	8.379GlyVal: 8.379 ± 0.098	1.608GlyTrp: 1.608 ± 0.041	2.15GlyTyr: 2.15 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	2.291HisAla: 2.291 ± 0.047	0.11HisCys: 0.11 ± 0.011	1.377HisAsp: 1.377 ± 0.035	1.136HisGlu: 1.136 ± 0.029	0.533HisPhe: 0.533 ± 0.027	2.012HisGly: 2.012 ± 0.045	0.612HisHis: 0.612 ± 0.028	0.656HisIle: 0.656 ± 0.024	0.198HisLys: 0.198 ± 0.012	2.209HisLeu: 2.209 ± 0.044	0.276HisMet: 0.276 ± 0.017	0.308HisAsn: 0.308 ± 0.016	1.477HisPro: 1.477 ± 0.041	0.539HisGln: 0.539 ± 0.022	1.647HisArg: 1.647 ± 0.039	0.837HisSer: 0.837 ± 0.028	1.004HisThr: 1.004 ± 0.028	1.537HisVal: 1.537 ± 0.039	0.32HisTrp: 0.32 ± 0.017	0.392HisTyr: 0.392 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	6.948IleAla: 6.948 ± 0.08	0.205IleCys: 0.205 ± 0.013	3.446IleAsp: 3.446 ± 0.06	2.787IleGlu: 2.787 ± 0.057	1.108IlePhe: 1.108 ± 0.034	4.785IleGly: 4.785 ± 0.075	0.661IleHis: 0.661 ± 0.025	1.904IleIle: 1.904 ± 0.05	0.739IleLys: 0.739 ± 0.029	3.929IleLeu: 3.929 ± 0.064	0.619IleMet: 0.619 ± 0.026	0.878IleAsn: 0.878 ± 0.033	2.374IlePro: 2.374 ± 0.044	0.937IleGln: 0.937 ± 0.033	2.609IleArg: 2.609 ± 0.052	2.271IleSer: 2.271 ± 0.05	2.991IleThr: 2.991 ± 0.051	4.905IleVal: 4.905 ± 0.072	0.449IleTrp: 0.449 ± 0.02	0.634IleTyr: 0.634 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	2.157LysAla: 2.157 ± 0.053	0.05LysCys: 0.05 ± 0.006	1.05LysAsp: 1.05 ± 0.038	0.828LysGlu: 0.828 ± 0.031	0.442LysPhe: 0.442 ± 0.023	1.357LysGly: 1.357 ± 0.043	0.457LysHis: 0.457 ± 0.02	0.766LysIle: 0.766 ± 0.034	0.575LysLys: 0.575 ± 0.028	1.93LysLeu: 1.93 ± 0.046	0.331LysMet: 0.331 ± 0.02	0.454LysAsn: 0.454 ± 0.023	1.185LysPro: 1.185 ± 0.034	0.773LysGln: 0.773 ± 0.026	1.605LysArg: 1.605 ± 0.04	0.998LysSer: 0.998 ± 0.034	1.244LysThr: 1.244 ± 0.035	1.477LysVal: 1.477 ± 0.045	0.19LysTrp: 0.19 ± 0.014	0.396LysTyr: 0.396 ± 0.018	0.0LysXaa: 0.0 ± 0.0
Leu	14.816LeuAla: 14.816 ± 0.144	0.489LeuCys: 0.489 ± 0.023	7.296LeuAsp: 7.296 ± 0.096	5.385LeuGlu: 5.385 ± 0.069	2.942LeuPhe: 2.942 ± 0.054	9.744LeuGly: 9.744 ± 0.098	1.921LeuHis: 1.921 ± 0.04	4.563LeuIle: 4.563 ± 0.074	1.539LeuLys: 1.539 ± 0.045	10.873LeuLeu: 10.873 ± 0.134	1.468LeuMet: 1.468 ± 0.037	1.725LeuAsn: 1.725 ± 0.045	5.642LeuPro: 5.642 ± 0.071	2.707LeuGln: 2.707 ± 0.048	7.41LeuArg: 7.41 ± 0.099	5.955LeuSer: 5.955 ± 0.072	6.141LeuThr: 6.141 ± 0.076	9.926LeuVal: 9.926 ± 0.119	1.163LeuTrp: 1.163 ± 0.035	1.597LeuTyr: 1.597 ± 0.045	0.002LeuXaa: 0.002 ± 0.001
Met	1.882MetAla: 1.882 ± 0.043	0.083MetCys: 0.083 ± 0.009	0.765MetAsp: 0.765 ± 0.027	0.61MetGlu: 0.61 ± 0.025	0.502MetPhe: 0.502 ± 0.022	1.131MetGly: 1.131 ± 0.033	0.312MetHis: 0.312 ± 0.015	0.837MetIle: 0.837 ± 0.029	0.33MetLys: 0.33 ± 0.017	1.859MetLeu: 1.859 ± 0.046	0.284MetMet: 0.284 ± 0.016	0.442MetAsn: 0.442 ± 0.02	1.004MetPro: 1.004 ± 0.033	0.528MetGln: 0.528 ± 0.023	1.222MetArg: 1.222 ± 0.031	1.416MetSer: 1.416 ± 0.035	1.684MetThr: 1.684 ± 0.042	1.287MetVal: 1.287 ± 0.032	0.17MetTrp: 0.17 ± 0.014	0.27MetTyr: 0.27 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.416AsnAla: 2.416 ± 0.043	0.101AsnCys: 0.101 ± 0.009	1.097AsnAsp: 1.097 ± 0.034	0.939AsnGlu: 0.939 ± 0.035	0.595AsnPhe: 0.595 ± 0.025	1.89AsnGly: 1.89 ± 0.046	0.322AsnHis: 0.322 ± 0.018	0.772AsnIle: 0.772 ± 0.027	0.345AsnLys: 0.345 ± 0.018	1.867AsnLeu: 1.867 ± 0.04	0.257AsnMet: 0.257 ± 0.017	0.397AsnAsn: 0.397 ± 0.023	1.463AsnPro: 1.463 ± 0.035	0.558AsnGln: 0.558 ± 0.025	1.334AsnArg: 1.334 ± 0.036	0.897AsnSer: 0.897 ± 0.029	1.139AsnThr: 1.139 ± 0.036	1.582AsnVal: 1.582 ± 0.042	0.272AsnTrp: 0.272 ± 0.019	0.457AsnTyr: 0.457 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	7.138ProAla: 7.138 ± 0.105	0.171ProCys: 0.171 ± 0.013	3.835ProAsp: 3.835 ± 0.066	3.951ProGlu: 3.951 ± 0.062	1.763ProPhe: 1.763 ± 0.04	4.981ProGly: 4.981 ± 0.072	0.991ProHis: 0.991 ± 0.032	2.256ProIle: 2.256 ± 0.042	1.112ProLys: 1.112 ± 0.038	4.728ProLeu: 4.728 ± 0.075	0.86ProMet: 0.86 ± 0.028	1.079ProAsn: 1.079 ± 0.031	2.219ProPro: 2.219 ± 0.054	1.496ProGln: 1.496 ± 0.04	3.071ProArg: 3.071 ± 0.055	3.618ProSer: 3.618 ± 0.071	3.751ProThr: 3.751 ± 0.068	4.946ProVal: 4.946 ± 0.069	0.828ProTrp: 0.828 ± 0.029	1.084ProTyr: 1.084 ± 0.032	0.002ProXaa: 0.002 ± 0.002
Gln	3.69GlnAla: 3.69 ± 0.068	0.097GlnCys: 0.097 ± 0.01	1.425GlnAsp: 1.425 ± 0.038	1.364GlnGlu: 1.364 ± 0.037	0.885GlnPhe: 0.885 ± 0.025	2.043GlnGly: 2.043 ± 0.047	0.7GlnHis: 0.7 ± 0.027	1.249GlnIle: 1.249 ± 0.033	0.552GlnLys: 0.552 ± 0.025	3.361GlnLeu: 3.361 ± 0.056	0.458GlnMet: 0.458 ± 0.023	0.601GlnAsn: 0.601 ± 0.03	1.697GlnPro: 1.697 ± 0.05	1.305GlnGln: 1.305 ± 0.051	2.329GlnArg: 2.329 ± 0.049	1.469GlnSer: 1.469 ± 0.038	1.577GlnThr: 1.577 ± 0.041	2.368GlnVal: 2.368 ± 0.048	0.419GlnTrp: 0.419 ± 0.018	0.632GlnTyr: 0.632 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	8.39ArgAla: 8.39 ± 0.11	0.26ArgCys: 0.26 ± 0.016	3.936ArgAsp: 3.936 ± 0.059	4.005ArgGlu: 4.005 ± 0.062	2.633ArgPhe: 2.633 ± 0.05	5.066ArgGly: 5.066 ± 0.061	1.551ArgHis: 1.551 ± 0.039	3.778ArgIle: 3.778 ± 0.064	1.322ArgLys: 1.322 ± 0.041	7.7ArgLeu: 7.7 ± 0.106	1.59ArgMet: 1.59 ± 0.037	1.338ArgAsn: 1.338 ± 0.032	3.773ArgPro: 3.773 ± 0.072	1.916ArgGln: 1.916 ± 0.039	6.392ArgArg: 6.392 ± 0.092	4.625ArgSer: 4.625 ± 0.068	4.279ArgThr: 4.279 ± 0.063	5.942ArgVal: 5.942 ± 0.072	1.193ArgTrp: 1.193 ± 0.038	1.554ArgTyr: 1.554 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	7.375SerAla: 7.375 ± 0.098	0.29SerCys: 0.29 ± 0.017	3.306SerAsp: 3.306 ± 0.055	2.937SerGlu: 2.937 ± 0.045	1.975SerPhe: 1.975 ± 0.048	6.053SerGly: 6.053 ± 0.077	0.968SerHis: 0.968 ± 0.033	2.84SerIle: 2.84 ± 0.05	1.16SerLys: 1.16 ± 0.036	5.707SerLeu: 5.707 ± 0.073	1.204SerMet: 1.204 ± 0.036	1.124SerAsn: 1.124 ± 0.029	3.065SerPro: 3.065 ± 0.054	1.386SerGln: 1.386 ± 0.033	3.78SerArg: 3.78 ± 0.063	3.76SerSer: 3.76 ± 0.072	4.038SerThr: 4.038 ± 0.064	5.052SerVal: 5.052 ± 0.071	1.03SerTrp: 1.03 ± 0.034	1.203SerTyr: 1.203 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	8.4ThrAla: 8.4 ± 0.117	0.257ThrCys: 0.257 ± 0.016	3.829ThrAsp: 3.829 ± 0.073	3.347ThrGlu: 3.347 ± 0.06	1.906ThrPhe: 1.906 ± 0.042	6.123ThrGly: 6.123 ± 0.08	0.997ThrHis: 0.997 ± 0.03	3.234ThrIle: 3.234 ± 0.06	1.311ThrLys: 1.311 ± 0.037	6.065ThrLeu: 6.065 ± 0.072	1.014ThrMet: 1.014 ± 0.031	1.214ThrAsn: 1.214 ± 0.036	4.168ThrPro: 4.168 ± 0.074	1.43ThrGln: 1.43 ± 0.038	3.724ThrArg: 3.724 ± 0.064	3.629ThrSer: 3.629 ± 0.06	4.586ThrThr: 4.586 ± 0.086	6.471ThrVal: 6.471 ± 0.119	0.857ThrTrp: 0.857 ± 0.03	1.07ThrTyr: 1.07 ± 0.03	0.0ThrXaa: 0.0 ± 0.0
Val	11.567ValAla: 11.567 ± 0.104	0.472ValCys: 0.472 ± 0.022	6.25ValAsp: 6.25 ± 0.093	5.329ValGlu: 5.329 ± 0.065	3.09ValPhe: 3.09 ± 0.053	7.533ValGly: 7.533 ± 0.088	1.724ValHis: 1.724 ± 0.035	4.296ValIle: 4.296 ± 0.069	1.48ValLys: 1.48 ± 0.041	9.827ValLeu: 9.827 ± 0.113	1.382ValMet: 1.382 ± 0.033	1.724ValAsn: 1.724 ± 0.046	4.874ValPro: 4.874 ± 0.067	2.348ValGln: 2.348 ± 0.05	5.887ValArg: 5.887 ± 0.091	5.418ValSer: 5.418 ± 0.076	6.099ValThr: 6.099 ± 0.115	9.546ValVal: 9.546 ± 0.123	1.16ValTrp: 1.16 ± 0.038	1.555ValTyr: 1.555 ± 0.037	0.001ValXaa: 0.001 ± 0.001
Trp	1.545TrpAla: 1.545 ± 0.042	0.086TrpCys: 0.086 ± 0.009	0.797TrpAsp: 0.797 ± 0.029	0.617TrpGlu: 0.617 ± 0.023	0.613TrpPhe: 0.613 ± 0.022	1.01TrpGly: 1.01 ± 0.034	0.304TrpHis: 0.304 ± 0.017	0.736TrpIle: 0.736 ± 0.027	0.296TrpLys: 0.296 ± 0.018	1.664TrpLeu: 1.664 ± 0.043	0.292TrpMet: 0.292 ± 0.014	0.442TrpAsn: 0.442 ± 0.023	0.675TrpPro: 0.675 ± 0.027	0.531TrpGln: 0.531 ± 0.022	1.171TrpArg: 1.171 ± 0.038	1.064TrpSer: 1.064 ± 0.029	0.963TrpThr: 0.963 ± 0.031	1.135TrpVal: 1.135 ± 0.03	0.372TrpTrp: 0.372 ± 0.02	0.284TrpTyr: 0.284 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.338TyrAla: 2.338 ± 0.043	0.106TyrCys: 0.106 ± 0.009	1.223TyrAsp: 1.223 ± 0.037	1.044TyrGlu: 1.044 ± 0.032	0.686TyrPhe: 0.686 ± 0.026	1.898TyrGly: 1.898 ± 0.042	0.276TyrHis: 0.276 ± 0.016	0.597TyrIle: 0.597 ± 0.025	0.304TyrLys: 0.304 ± 0.016	2.206TyrLeu: 2.206 ± 0.044	0.197TyrMet: 0.197 ± 0.013	0.428TyrAsn: 0.428 ± 0.022	1.014TyrPro: 1.014 ± 0.031	0.584TyrGln: 0.584 ± 0.025	1.679TyrArg: 1.679 ± 0.04	1.058TyrSer: 1.058 ± 0.03	1.183TyrThr: 1.183 ± 0.039	1.482TyrVal: 1.482 ± 0.039	0.321TyrTrp: 0.321 ± 0.019	0.441TyrTyr: 0.441 ± 0.02	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.003XaaAla: 0.003 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.002XaaPro: 0.002 ± 0.002	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.001XaaThr: 0.001 ± 0.001	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3521 proteins (1149947 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---