Amino acid dipepetide frequency for Vagococcus teuberi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.902AlaAla: 3.902 ± 0.1
0.477AlaCys: 0.477 ± 0.03
3.123AlaAsp: 3.123 ± 0.073
3.511AlaGlu: 3.511 ± 0.091
2.772AlaPhe: 2.772 ± 0.076
4.078AlaGly: 4.078 ± 0.105
1.059AlaHis: 1.059 ± 0.048
5.656AlaIle: 5.656 ± 0.113
4.73AlaLys: 4.73 ± 0.095
6.001AlaLeu: 6.001 ± 0.129
1.875AlaMet: 1.875 ± 0.057
2.863AlaAsn: 2.863 ± 0.077
1.775AlaPro: 1.775 ± 0.061
2.132AlaGln: 2.132 ± 0.063
2.057AlaArg: 2.057 ± 0.067
3.891AlaSer: 3.891 ± 0.089
3.921AlaThr: 3.921 ± 0.084
4.179AlaVal: 4.179 ± 0.097
0.423AlaTrp: 0.423 ± 0.025
2.175AlaTyr: 2.175 ± 0.062
0.0AlaXaa: 0.0 ± 0.0
Cys
0.348CysAla: 0.348 ± 0.026
0.085CysCys: 0.085 ± 0.012
0.413CysAsp: 0.413 ± 0.026
0.391CysGlu: 0.391 ± 0.029
0.33CysPhe: 0.33 ± 0.026
0.592CysGly: 0.592 ± 0.034
0.224CysHis: 0.224 ± 0.02
0.491CysIle: 0.491 ± 0.028
0.292CysLys: 0.292 ± 0.023
0.731CysLeu: 0.731 ± 0.042
0.171CysMet: 0.171 ± 0.016
0.184CysAsn: 0.184 ± 0.017
0.303CysPro: 0.303 ± 0.025
0.313CysGln: 0.313 ± 0.02
0.225CysArg: 0.225 ± 0.02
0.419CysSer: 0.419 ± 0.028
0.318CysThr: 0.318 ± 0.024
0.426CysVal: 0.426 ± 0.028
0.063CysTrp: 0.063 ± 0.011
0.227CysTyr: 0.227 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.369AspAla: 3.369 ± 0.071
0.361AspCys: 0.361 ± 0.026
3.445AspAsp: 3.445 ± 0.096
4.754AspGlu: 4.754 ± 0.111
2.662AspPhe: 2.662 ± 0.073
3.601AspGly: 3.601 ± 0.081
0.91AspHis: 0.91 ± 0.042
5.268AspIle: 5.268 ± 0.095
4.597AspLys: 4.597 ± 0.105
5.111AspLeu: 5.111 ± 0.095
1.853AspMet: 1.853 ± 0.052
2.78AspAsn: 2.78 ± 0.082
1.557AspPro: 1.557 ± 0.045
1.494AspGln: 1.494 ± 0.053
1.891AspArg: 1.891 ± 0.066
3.153AspSer: 3.153 ± 0.068
3.35AspThr: 3.35 ± 0.076
4.663AspVal: 4.663 ± 0.097
0.564AspTrp: 0.564 ± 0.035
2.758AspTyr: 2.758 ± 0.074
0.0AspXaa: 0.0 ± 0.0
Glu
4.705GluAla: 4.705 ± 0.1
0.411GluCys: 0.411 ± 0.031
4.007GluAsp: 4.007 ± 0.083
6.412GluGlu: 6.412 ± 0.141
2.662GluPhe: 2.662 ± 0.076
3.805GluGly: 3.805 ± 0.102
1.25GluHis: 1.25 ± 0.047
4.942GluIle: 4.942 ± 0.096
6.818GluLys: 6.818 ± 0.137
7.592GluLeu: 7.592 ± 0.142
2.24GluMet: 2.24 ± 0.066
3.669GluAsn: 3.669 ± 0.078
1.916GluPro: 1.916 ± 0.101
2.841GluGln: 2.841 ± 0.087
2.783GluArg: 2.783 ± 0.073
3.959GluSer: 3.959 ± 0.088
4.401GluThr: 4.401 ± 0.096
4.776GluVal: 4.776 ± 0.119
0.671GluTrp: 0.671 ± 0.036
2.303GluTyr: 2.303 ± 0.065
0.0GluXaa: 0.0 ± 0.0
Phe
2.399PheAla: 2.399 ± 0.067
0.343PheCys: 0.343 ± 0.028
2.934PheAsp: 2.934 ± 0.069
2.631PheGlu: 2.631 ± 0.075
2.364PhePhe: 2.364 ± 0.087
3.208PheGly: 3.208 ± 0.088
0.761PheHis: 0.761 ± 0.038
3.944PheIle: 3.944 ± 0.104
2.768PheLys: 2.768 ± 0.065
4.338PheLeu: 4.338 ± 0.099
1.136PheMet: 1.136 ± 0.039
2.306PheAsn: 2.306 ± 0.063
1.462PhePro: 1.462 ± 0.05
1.255PheGln: 1.255 ± 0.043
1.276PheArg: 1.276 ± 0.048
3.567PheSer: 3.567 ± 0.084
2.313PheThr: 2.313 ± 0.07
3.087PheVal: 3.087 ± 0.079
0.375PheTrp: 0.375 ± 0.024
1.935PheTyr: 1.935 ± 0.057
0.0PheXaa: 0.0 ± 0.0
Gly
4.179GlyAla: 4.179 ± 0.095
0.496GlyCys: 0.496 ± 0.026
3.223GlyAsp: 3.223 ± 0.072
4.179GlyGlu: 4.179 ± 0.089
3.138GlyPhe: 3.138 ± 0.07
4.327GlyGly: 4.327 ± 0.106
1.172GlyHis: 1.172 ± 0.05
5.643GlyIle: 5.643 ± 0.109
4.879GlyLys: 4.879 ± 0.122
6.434GlyLeu: 6.434 ± 0.127
2.059GlyMet: 2.059 ± 0.066
2.649GlyAsn: 2.649 ± 0.066
1.368GlyPro: 1.368 ± 0.044
2.15GlyGln: 2.15 ± 0.067
2.173GlyArg: 2.173 ± 0.065
3.828GlySer: 3.828 ± 0.087
4.017GlyThr: 4.017 ± 0.126
4.97GlyVal: 4.97 ± 0.107
0.593GlyTrp: 0.593 ± 0.04
2.574GlyTyr: 2.574 ± 0.082
0.0GlyXaa: 0.0 ± 0.0
His
1.097HisAla: 1.097 ± 0.043
0.153HisCys: 0.153 ± 0.017
1.087HisAsp: 1.087 ± 0.052
1.117HisGlu: 1.117 ± 0.041
0.978HisPhe: 0.978 ± 0.041
1.149HisGly: 1.149 ± 0.049
0.605HisHis: 0.605 ± 0.034
1.397HisIle: 1.397 ± 0.05
0.955HisLys: 0.955 ± 0.047
1.963HisLeu: 1.963 ± 0.063
0.444HisMet: 0.444 ± 0.03
0.666HisAsn: 0.666 ± 0.031
1.011HisPro: 1.011 ± 0.047
0.86HisGln: 0.86 ± 0.04
0.713HisArg: 0.713 ± 0.036
1.097HisSer: 1.097 ± 0.048
0.961HisThr: 0.961 ± 0.044
1.267HisVal: 1.267 ± 0.048
0.153HisTrp: 0.153 ± 0.016
0.918HisTyr: 0.918 ± 0.041
0.0HisXaa: 0.0 ± 0.0
Ile
5.311IleAla: 5.311 ± 0.119
0.635IleCys: 0.635 ± 0.037
5.104IleAsp: 5.104 ± 0.1
5.779IleGlu: 5.779 ± 0.092
3.319IlePhe: 3.319 ± 0.093
5.832IleGly: 5.832 ± 0.124
1.455IleHis: 1.455 ± 0.056
6.425IleIle: 6.425 ± 0.14
5.691IleLys: 5.691 ± 0.113
7.452IleLeu: 7.452 ± 0.117
1.963IleMet: 1.963 ± 0.065
3.962IleAsn: 3.962 ± 0.084
3.17IlePro: 3.17 ± 0.075
2.78IleGln: 2.78 ± 0.072
2.732IleArg: 2.732 ± 0.076
5.563IleSer: 5.563 ± 0.078
4.41IleThr: 4.41 ± 0.095
5.686IleVal: 5.686 ± 0.12
0.549IleTrp: 0.549 ± 0.029
2.707IleTyr: 2.707 ± 0.078
0.0IleXaa: 0.0 ± 0.0
Lys
4.038LysAla: 4.038 ± 0.081
0.265LysCys: 0.265 ± 0.024
4.768LysAsp: 4.768 ± 0.102
8.09LysGlu: 8.09 ± 0.129
1.887LysPhe: 1.887 ± 0.065
4.221LysGly: 4.221 ± 0.088
1.378LysHis: 1.378 ± 0.046
5.19LysIle: 5.19 ± 0.103
7.233LysLys: 7.233 ± 0.126
5.809LysLeu: 5.809 ± 0.095
2.279LysMet: 2.279 ± 0.065
4.211LysAsn: 4.211 ± 0.091
2.203LysPro: 2.203 ± 0.087
3.649LysGln: 3.649 ± 0.105
3.267LysArg: 3.267 ± 0.07
3.972LysSer: 3.972 ± 0.087
4.201LysThr: 4.201 ± 0.084
4.686LysVal: 4.686 ± 0.095
0.62LysTrp: 0.62 ± 0.031
2.359LysTyr: 2.359 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
6.492LeuAla: 6.492 ± 0.108
0.666LeuCys: 0.666 ± 0.035
5.597LeuAsp: 5.597 ± 0.109
6.447LeuGlu: 6.447 ± 0.115
4.789LeuPhe: 4.789 ± 0.112
6.155LeuGly: 6.155 ± 0.118
1.436LeuHis: 1.436 ± 0.048
7.398LeuIle: 7.398 ± 0.133
6.611LeuLys: 6.611 ± 0.121
9.684LeuLeu: 9.684 ± 0.16
2.599LeuMet: 2.599 ± 0.071
4.842LeuAsn: 4.842 ± 0.099
3.778LeuPro: 3.778 ± 0.088
2.772LeuGln: 2.772 ± 0.073
2.987LeuArg: 2.987 ± 0.072
7.939LeuSer: 7.939 ± 0.131
6.386LeuThr: 6.386 ± 0.112
6.991LeuVal: 6.991 ± 0.113
0.665LeuTrp: 0.665 ± 0.038
3.14LeuTyr: 3.14 ± 0.073
0.0LeuXaa: 0.0 ± 0.0
Met
1.761MetAla: 1.761 ± 0.06
0.126MetCys: 0.126 ± 0.013
1.52MetAsp: 1.52 ± 0.057
1.643MetGlu: 1.643 ± 0.054
1.071MetPhe: 1.071 ± 0.045
1.737MetGly: 1.737 ± 0.065
0.393MetHis: 0.393 ± 0.024
2.5MetIle: 2.5 ± 0.072
2.233MetLys: 2.233 ± 0.067
2.571MetLeu: 2.571 ± 0.066
1.021MetMet: 1.021 ± 0.045
1.465MetAsn: 1.465 ± 0.052
0.981MetPro: 0.981 ± 0.04
0.872MetGln: 0.872 ± 0.038
0.892MetArg: 0.892 ± 0.044
2.192MetSer: 2.192 ± 0.065
2.39MetThr: 2.39 ± 0.063
1.878MetVal: 1.878 ± 0.06
0.177MetTrp: 0.177 ± 0.016
0.819MetTyr: 0.819 ± 0.039
0.0MetXaa: 0.0 ± 0.0
Asn
2.593AsnAla: 2.593 ± 0.071
0.32AsnCys: 0.32 ± 0.026
2.828AsnAsp: 2.828 ± 0.081
3.468AsnGlu: 3.468 ± 0.088
1.792AsnPhe: 1.792 ± 0.057
3.221AsnGly: 3.221 ± 0.086
1.129AsnHis: 1.129 ± 0.042
3.778AsnIle: 3.778 ± 0.081
3.71AsnLys: 3.71 ± 0.087
4.047AsnLeu: 4.047 ± 0.089
1.358AsnMet: 1.358 ± 0.048
2.644AsnAsn: 2.644 ± 0.089
2.067AsnPro: 2.067 ± 0.063
2.551AsnGln: 2.551 ± 0.07
1.941AsnArg: 1.941 ± 0.058
2.584AsnSer: 2.584 ± 0.072
2.467AsnThr: 2.467 ± 0.064
3.267AsnVal: 3.267 ± 0.075
0.516AsnTrp: 0.516 ± 0.033
2.024AsnTyr: 2.024 ± 0.066
0.0AsnXaa: 0.0 ± 0.0
Pro
1.694ProAla: 1.694 ± 0.059
0.167ProCys: 0.167 ± 0.016
1.848ProAsp: 1.848 ± 0.052
2.719ProGlu: 2.719 ± 0.106
1.794ProPhe: 1.794 ± 0.06
1.951ProGly: 1.951 ± 0.065
0.579ProHis: 0.579 ± 0.029
2.875ProIle: 2.875 ± 0.07
2.505ProLys: 2.505 ± 0.066
3.168ProLeu: 3.168 ± 0.081
0.9ProMet: 0.9 ± 0.045
1.756ProAsn: 1.756 ± 0.049
0.617ProPro: 0.617 ± 0.033
1.043ProGln: 1.043 ± 0.051
0.859ProArg: 0.859 ± 0.036
2.24ProSer: 2.24 ± 0.068
2.425ProThr: 2.425 ± 0.123
2.566ProVal: 2.566 ± 0.082
0.26ProTrp: 0.26 ± 0.021
1.336ProTyr: 1.336 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
2.566GlnAla: 2.566 ± 0.077
0.196GlnCys: 0.196 ± 0.018
1.868GlnAsp: 1.868 ± 0.058
2.782GlnGlu: 2.782 ± 0.077
1.518GlnPhe: 1.518 ± 0.051
1.945GlnGly: 1.945 ± 0.058
0.685GlnHis: 0.685 ± 0.037
2.521GlnIle: 2.521 ± 0.059
2.863GlnLys: 2.863 ± 0.075
4.222GlnLeu: 4.222 ± 0.111
1.034GlnMet: 1.034 ± 0.042
1.575GlnAsn: 1.575 ± 0.057
1.162GlnPro: 1.162 ± 0.048
1.802GlnGln: 1.802 ± 0.072
1.424GlnArg: 1.424 ± 0.053
2.361GlnSer: 2.361 ± 0.075
2.356GlnThr: 2.356 ± 0.071
2.598GlnVal: 2.598 ± 0.069
0.307GlnTrp: 0.307 ± 0.022
1.228GlnTyr: 1.228 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
1.971ArgAla: 1.971 ± 0.06
0.225ArgCys: 0.225 ± 0.018
1.853ArgAsp: 1.853 ± 0.063
2.652ArgGlu: 2.652 ± 0.072
1.693ArgPhe: 1.693 ± 0.05
2.016ArgGly: 2.016 ± 0.062
0.698ArgHis: 0.698 ± 0.039
2.659ArgIle: 2.659 ± 0.066
2.631ArgLys: 2.631 ± 0.076
3.746ArgLeu: 3.746 ± 0.09
1.036ArgMet: 1.036 ± 0.043
1.49ArgAsn: 1.49 ± 0.048
1.142ArgPro: 1.142 ± 0.052
1.626ArgGln: 1.626 ± 0.053
1.543ArgArg: 1.543 ± 0.054
1.734ArgSer: 1.734 ± 0.054
1.671ArgThr: 1.671 ± 0.058
2.573ArgVal: 2.573 ± 0.077
0.26ArgTrp: 0.26 ± 0.021
1.454ArgTyr: 1.454 ± 0.052
0.0ArgXaa: 0.0 ± 0.0
Ser
3.524SerAla: 3.524 ± 0.09
0.363SerCys: 0.363 ± 0.024
3.861SerAsp: 3.861 ± 0.091
4.277SerGlu: 4.277 ± 0.1
3.291SerPhe: 3.291 ± 0.089
4.514SerGly: 4.514 ± 0.091
1.431SerHis: 1.431 ± 0.055
5.485SerIle: 5.485 ± 0.099
4.211SerLys: 4.211 ± 0.094
6.715SerLeu: 6.715 ± 0.125
1.701SerMet: 1.701 ± 0.06
2.918SerAsn: 2.918 ± 0.066
1.998SerPro: 1.998 ± 0.06
2.589SerGln: 2.589 ± 0.068
2.185SerArg: 2.185 ± 0.067
4.416SerSer: 4.416 ± 0.105
3.682SerThr: 3.682 ± 0.093
4.716SerVal: 4.716 ± 0.085
0.59SerTrp: 0.59 ± 0.031
2.503SerTyr: 2.503 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
3.347ThrAla: 3.347 ± 0.075
0.318ThrCys: 0.318 ± 0.021
3.586ThrAsp: 3.586 ± 0.081
3.683ThrGlu: 3.683 ± 0.139
2.737ThrPhe: 2.737 ± 0.068
4.11ThrGly: 4.11 ± 0.094
1.303ThrHis: 1.303 ± 0.055
5.253ThrIle: 5.253 ± 0.106
4.05ThrLys: 4.05 ± 0.089
5.913ThrLeu: 5.913 ± 0.107
1.49ThrMet: 1.49 ± 0.05
3.027ThrAsn: 3.027 ± 0.081
2.606ThrPro: 2.606 ± 0.072
2.064ThrGln: 2.064 ± 0.062
1.807ThrArg: 1.807 ± 0.053
3.906ThrSer: 3.906 ± 0.084
3.912ThrThr: 3.912 ± 0.106
4.287ThrVal: 4.287 ± 0.124
0.479ThrTrp: 0.479 ± 0.034
2.316ThrTyr: 2.316 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
4.86ValAla: 4.86 ± 0.104
0.602ValCys: 0.602 ± 0.032
4.168ValAsp: 4.168 ± 0.089
4.796ValGlu: 4.796 ± 0.098
3.223ValPhe: 3.223 ± 0.086
4.67ValGly: 4.67 ± 0.1
1.028ValHis: 1.028 ± 0.037
5.981ValIle: 5.981 ± 0.116
4.728ValLys: 4.728 ± 0.095
6.88ValLeu: 6.88 ± 0.113
1.981ValMet: 1.981 ± 0.061
3.166ValAsn: 3.166 ± 0.07
2.604ValPro: 2.604 ± 0.073
1.93ValGln: 1.93 ± 0.068
2.135ValArg: 2.135 ± 0.063
5.351ValSer: 5.351 ± 0.1
4.494ValThr: 4.494 ± 0.095
5.58ValVal: 5.58 ± 0.126
0.491ValTrp: 0.491 ± 0.025
2.493ValTyr: 2.493 ± 0.068
0.0ValXaa: 0.0 ± 0.0
Trp
0.383TrpAla: 0.383 ± 0.029
0.056TrpCys: 0.056 ± 0.009
0.458TrpAsp: 0.458 ± 0.026
0.496TrpGlu: 0.496 ± 0.028
0.434TrpPhe: 0.434 ± 0.028
0.497TrpGly: 0.497 ± 0.033
0.186TrpHis: 0.186 ± 0.019
0.622TrpIle: 0.622 ± 0.031
0.537TrpLys: 0.537 ± 0.032
1.044TrpLeu: 1.044 ± 0.044
0.242TrpMet: 0.242 ± 0.021
0.431TrpAsn: 0.431 ± 0.031
0.182TrpPro: 0.182 ± 0.02
0.419TrpGln: 0.419 ± 0.029
0.308TrpArg: 0.308 ± 0.023
0.472TrpSer: 0.472 ± 0.028
0.446TrpThr: 0.446 ± 0.028
0.572TrpVal: 0.572 ± 0.033
0.081TrpTrp: 0.081 ± 0.011
0.318TrpTyr: 0.318 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.061TyrAla: 2.061 ± 0.058
0.28TyrCys: 0.28 ± 0.023
2.452TyrAsp: 2.452 ± 0.072
2.336TyrGlu: 2.336 ± 0.072
1.948TyrPhe: 1.948 ± 0.053
2.424TyrGly: 2.424 ± 0.064
0.913TyrHis: 0.913 ± 0.045
2.495TyrIle: 2.495 ± 0.069
2.284TyrLys: 2.284 ± 0.064
3.954TyrLeu: 3.954 ± 0.095
0.859TyrMet: 0.859 ± 0.036
1.701TyrAsn: 1.701 ± 0.052
1.397TyrPro: 1.397 ± 0.053
1.87TyrGln: 1.87 ± 0.073
1.474TyrArg: 1.474 ± 0.054
2.326TyrSer: 2.326 ± 0.074
2.074TyrThr: 2.074 ± 0.078
2.392TyrVal: 2.392 ± 0.066
0.35TyrTrp: 0.35 ± 0.026
1.649TyrTyr: 1.649 ± 0.058
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1935 proteins (603234 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski