Amino acid dipepetide frequency for Oceanibacterium hippocampi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.989AlaAla: 18.989 ± 0.184	1.133AlaCys: 1.133 ± 0.033	7.536AlaAsp: 7.536 ± 0.089	8.429AlaGlu: 8.429 ± 0.076	4.558AlaPhe: 4.558 ± 0.061	12.4AlaGly: 12.4 ± 0.097	2.128AlaHis: 2.128 ± 0.039	6.756AlaIle: 6.756 ± 0.076	2.996AlaLys: 2.996 ± 0.052	14.118AlaLeu: 14.118 ± 0.129	3.58AlaMet: 3.58 ± 0.051	2.709AlaAsn: 2.709 ± 0.046	5.652AlaPro: 5.652 ± 0.083	2.847AlaGln: 2.847 ± 0.05	10.08AlaArg: 10.08 ± 0.105	5.769AlaSer: 5.769 ± 0.062	6.114AlaThr: 6.114 ± 0.062	9.272AlaVal: 9.272 ± 0.098	1.497AlaTrp: 1.497 ± 0.036	2.594AlaTyr: 2.594 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.933CysAla: 0.933 ± 0.028	0.1CysCys: 0.1 ± 0.009	0.576CysAsp: 0.576 ± 0.021	0.473CysGlu: 0.473 ± 0.018	0.35CysPhe: 0.35 ± 0.016	0.968CysGly: 0.968 ± 0.028	0.283CysHis: 0.283 ± 0.018	0.383CysIle: 0.383 ± 0.016	0.187CysLys: 0.187 ± 0.011	0.869CysLeu: 0.869 ± 0.025	0.187CysMet: 0.187 ± 0.012	0.227CysAsn: 0.227 ± 0.015	0.453CysPro: 0.453 ± 0.02	0.234CysGln: 0.234 ± 0.012	0.795CysArg: 0.795 ± 0.026	0.401CysSer: 0.401 ± 0.016	0.395CysThr: 0.395 ± 0.015	0.623CysVal: 0.623 ± 0.023	0.119CysTrp: 0.119 ± 0.009	0.22CysTyr: 0.22 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	6.683AspAla: 6.683 ± 0.069	0.596AspCys: 0.596 ± 0.018	3.808AspAsp: 3.808 ± 0.06	3.73AspGlu: 3.73 ± 0.057	2.276AspPhe: 2.276 ± 0.04	6.348AspGly: 6.348 ± 0.082	1.239AspHis: 1.239 ± 0.029	3.229AspIle: 3.229 ± 0.047	1.433AspLys: 1.433 ± 0.032	5.906AspLeu: 5.906 ± 0.073	1.428AspMet: 1.428 ± 0.029	1.321AspAsn: 1.321 ± 0.035	3.744AspPro: 3.744 ± 0.057	1.431AspGln: 1.431 ± 0.033	5.032AspArg: 5.032 ± 0.055	2.51AspSer: 2.51 ± 0.04	2.05AspThr: 2.05 ± 0.036	3.986AspVal: 3.986 ± 0.065	1.15AspTrp: 1.15 ± 0.028	1.624AspTyr: 1.624 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	8.439GluAla: 8.439 ± 0.091	0.403GluCys: 0.403 ± 0.016	2.763GluAsp: 2.763 ± 0.049	3.271GluGlu: 3.271 ± 0.055	1.791GluPhe: 1.791 ± 0.034	4.422GluGly: 4.422 ± 0.063	1.158GluHis: 1.158 ± 0.033	3.958GluIle: 3.958 ± 0.047	2.101GluLys: 2.101 ± 0.04	5.574GluLeu: 5.574 ± 0.065	1.557GluMet: 1.557 ± 0.031	1.593GluAsn: 1.593 ± 0.035	2.886GluPro: 2.886 ± 0.048	1.995GluGln: 1.995 ± 0.04	5.447GluArg: 5.447 ± 0.068	2.715GluSer: 2.715 ± 0.046	3.633GluThr: 3.633 ± 0.052	3.858GluVal: 3.858 ± 0.05	0.699GluTrp: 0.699 ± 0.025	1.006GluTyr: 1.006 ± 0.027	0.0GluXaa: 0.0 ± 0.0
Phe	4.732PheAla: 4.732 ± 0.06	0.425PheCys: 0.425 ± 0.018	2.672PheAsp: 2.672 ± 0.046	2.235PheGlu: 2.235 ± 0.038	1.333PhePhe: 1.333 ± 0.035	3.8PheGly: 3.8 ± 0.053	0.775PheHis: 0.775 ± 0.027	1.535PheIle: 1.535 ± 0.036	0.751PheLys: 0.751 ± 0.02	3.54PheLeu: 3.54 ± 0.052	0.783PheMet: 0.783 ± 0.025	0.944PheAsn: 0.944 ± 0.031	1.613PhePro: 1.613 ± 0.039	0.932PheGln: 0.932 ± 0.025	2.678PheArg: 2.678 ± 0.049	1.989PheSer: 1.989 ± 0.039	1.924PheThr: 1.924 ± 0.035	2.872PheVal: 2.872 ± 0.043	0.541PheTrp: 0.541 ± 0.02	0.923PheTyr: 0.923 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	10.157GlyAla: 10.157 ± 0.095	0.852GlyCys: 0.852 ± 0.024	5.205GlyAsp: 5.205 ± 0.072	5.462GlyGlu: 5.462 ± 0.067	3.604GlyPhe: 3.604 ± 0.048	8.074GlyGly: 8.074 ± 0.104	2.004GlyHis: 2.004 ± 0.038	5.062GlyIle: 5.062 ± 0.062	2.953GlyLys: 2.953 ± 0.049	9.596GlyLeu: 9.596 ± 0.096	2.41GlyMet: 2.41 ± 0.039	2.298GlyAsn: 2.298 ± 0.049	3.947GlyPro: 3.947 ± 0.052	2.68GlyGln: 2.68 ± 0.045	7.396GlyArg: 7.396 ± 0.084	4.576GlySer: 4.576 ± 0.064	4.589GlyThr: 4.589 ± 0.061	6.264GlyVal: 6.264 ± 0.068	1.285GlyTrp: 1.285 ± 0.032	2.488GlyTyr: 2.488 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.226HisAla: 2.226 ± 0.039	0.283HisCys: 0.283 ± 0.013	1.263HisAsp: 1.263 ± 0.031	1.094HisGlu: 1.094 ± 0.026	0.846HisPhe: 0.846 ± 0.026	2.008HisGly: 2.008 ± 0.039	0.5HisHis: 0.5 ± 0.023	0.831HisIle: 0.831 ± 0.027	0.422HisLys: 0.422 ± 0.02	2.032HisLeu: 2.032 ± 0.041	0.485HisMet: 0.485 ± 0.018	0.432HisAsn: 0.432 ± 0.018	1.328HisPro: 1.328 ± 0.031	0.507HisGln: 0.507 ± 0.018	1.586HisArg: 1.586 ± 0.033	0.886HisSer: 0.886 ± 0.025	0.69HisThr: 0.69 ± 0.02	1.624HisVal: 1.624 ± 0.038	0.32HisTrp: 0.32 ± 0.014	0.617HisTyr: 0.617 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	7.707IleAla: 7.707 ± 0.08	0.51IleCys: 0.51 ± 0.018	3.644IleAsp: 3.644 ± 0.049	3.525IleGlu: 3.525 ± 0.046	1.794IlePhe: 1.794 ± 0.042	5.303IleGly: 5.303 ± 0.06	0.918IleHis: 0.918 ± 0.027	2.101IleIle: 2.101 ± 0.043	1.135IleLys: 1.135 ± 0.031	4.693IleLeu: 4.693 ± 0.065	0.948IleMet: 0.948 ± 0.029	1.263IleAsn: 1.263 ± 0.031	2.27IlePro: 2.27 ± 0.041	1.046IleGln: 1.046 ± 0.026	3.735IleArg: 3.735 ± 0.052	2.571IleSer: 2.571 ± 0.044	2.421IleThr: 2.421 ± 0.045	4.591IleVal: 4.591 ± 0.06	0.607IleTrp: 0.607 ± 0.023	1.192IleTyr: 1.192 ± 0.029	0.0IleXaa: 0.0 ± 0.0
Lys	3.593LysAla: 3.593 ± 0.052	0.167LysCys: 0.167 ± 0.011	1.362LysAsp: 1.362 ± 0.03	1.372LysGlu: 1.372 ± 0.035	0.73LysPhe: 0.73 ± 0.023	2.274LysGly: 2.274 ± 0.046	0.472LysHis: 0.472 ± 0.017	1.438LysIle: 1.438 ± 0.035	0.971LysLys: 0.971 ± 0.029	2.665LysLeu: 2.665 ± 0.045	0.622LysMet: 0.622 ± 0.024	0.655LysAsn: 0.655 ± 0.023	1.656LysPro: 1.656 ± 0.041	0.772LysGln: 0.772 ± 0.026	2.187LysArg: 2.187 ± 0.042	1.555LysSer: 1.555 ± 0.036	1.498LysThr: 1.498 ± 0.034	2.008LysVal: 2.008 ± 0.04	0.304LysTrp: 0.304 ± 0.015	0.558LysTyr: 0.558 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	14.782LeuAla: 14.782 ± 0.134	0.883LeuCys: 0.883 ± 0.026	6.509LeuAsp: 6.509 ± 0.076	5.569LeuGlu: 5.569 ± 0.07	3.861LeuPhe: 3.861 ± 0.064	9.113LeuGly: 9.113 ± 0.096	1.892LeuHis: 1.892 ± 0.035	5.026LeuIle: 5.026 ± 0.074	2.971LeuLys: 2.971 ± 0.047	10.108LeuLeu: 10.108 ± 0.125	2.257LeuMet: 2.257 ± 0.044	2.387LeuAsn: 2.387 ± 0.042	5.689LeuPro: 5.689 ± 0.073	2.534LeuGln: 2.534 ± 0.044	7.295LeuArg: 7.295 ± 0.091	5.73LeuSer: 5.73 ± 0.064	5.129LeuThr: 5.129 ± 0.059	7.908LeuVal: 7.908 ± 0.078	1.142LeuTrp: 1.142 ± 0.031	2.081LeuTyr: 2.081 ± 0.04	0.0LeuXaa: 0.0 ± 0.0
Met	3.271MetAla: 3.271 ± 0.052	0.152MetCys: 0.152 ± 0.011	1.03MetAsp: 1.03 ± 0.027	1.095MetGlu: 1.095 ± 0.027	0.699MetPhe: 0.699 ± 0.02	1.648MetGly: 1.648 ± 0.033	0.462MetHis: 0.462 ± 0.017	1.39MetIle: 1.39 ± 0.033	0.845MetLys: 0.845 ± 0.025	2.582MetLeu: 2.582 ± 0.042	0.592MetMet: 0.592 ± 0.022	0.775MetAsn: 0.775 ± 0.023	1.492MetPro: 1.492 ± 0.033	0.76MetGln: 0.76 ± 0.023	1.834MetArg: 1.834 ± 0.036	1.658MetSer: 1.658 ± 0.033	1.871MetThr: 1.871 ± 0.031	1.684MetVal: 1.684 ± 0.033	0.202MetTrp: 0.202 ± 0.013	0.308MetTyr: 0.308 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.842AsnAla: 2.842 ± 0.049	0.26AsnCys: 0.26 ± 0.014	1.313AsnAsp: 1.313 ± 0.035	1.292AsnGlu: 1.292 ± 0.031	0.884AsnPhe: 0.884 ± 0.026	2.473AsnGly: 2.473 ± 0.049	0.454AsnHis: 0.454 ± 0.017	1.263AsnIle: 1.263 ± 0.031	0.552AsnLys: 0.552 ± 0.021	2.466AsnLeu: 2.466 ± 0.043	0.618AsnMet: 0.618 ± 0.024	0.583AsnAsn: 0.583 ± 0.024	1.674AsnPro: 1.674 ± 0.033	0.658AsnGln: 0.658 ± 0.022	1.964AsnArg: 1.964 ± 0.044	1.129AsnSer: 1.129 ± 0.031	0.986AsnThr: 0.986 ± 0.025	1.844AsnVal: 1.844 ± 0.037	0.409AsnTrp: 0.409 ± 0.017	0.62AsnTyr: 0.62 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.904ProAla: 6.904 ± 0.093	0.353ProCys: 0.353 ± 0.018	3.899ProAsp: 3.899 ± 0.055	3.91ProGlu: 3.91 ± 0.062	1.996ProPhe: 1.996 ± 0.043	4.951ProGly: 4.951 ± 0.061	1.006ProHis: 1.006 ± 0.025	2.274ProIle: 2.274 ± 0.041	1.46ProLys: 1.46 ± 0.035	4.947ProLeu: 4.947 ± 0.067	1.127ProMet: 1.127 ± 0.029	1.151ProAsn: 1.151 ± 0.027	2.648ProPro: 2.648 ± 0.054	1.17ProGln: 1.17 ± 0.028	3.02ProArg: 3.02 ± 0.051	2.496ProSer: 2.496 ± 0.046	2.412ProThr: 2.412 ± 0.039	4.329ProVal: 4.329 ± 0.057	0.709ProTrp: 0.709 ± 0.023	1.165ProTyr: 1.165 ± 0.025	0.0ProXaa: 0.0 ± 0.0
Gln	3.612GlnAla: 3.612 ± 0.059	0.198GlnCys: 0.198 ± 0.013	1.289GlnAsp: 1.289 ± 0.03	1.367GlnGlu: 1.367 ± 0.031	0.91GlnPhe: 0.91 ± 0.023	2.176GlnGly: 2.176 ± 0.038	0.528GlnHis: 0.528 ± 0.018	1.577GlnIle: 1.577 ± 0.036	0.827GlnLys: 0.827 ± 0.027	2.356GlnLeu: 2.356 ± 0.037	0.725GlnMet: 0.725 ± 0.023	0.715GlnAsn: 0.715 ± 0.021	1.445GlnPro: 1.445 ± 0.036	0.968GlnGln: 0.968 ± 0.028	2.111GlnArg: 2.111 ± 0.035	1.492GlnSer: 1.492 ± 0.029	1.252GlnThr: 1.252 ± 0.032	2.046GlnVal: 2.046 ± 0.036	0.314GlnTrp: 0.314 ± 0.013	0.517GlnTyr: 0.517 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.919ArgAla: 8.919 ± 0.105	0.583ArgCys: 0.583 ± 0.02	4.729ArgAsp: 4.729 ± 0.064	4.742ArgGlu: 4.742 ± 0.062	3.227ArgPhe: 3.227 ± 0.052	5.193ArgGly: 5.193 ± 0.055	2.04ArgHis: 2.04 ± 0.04	4.489ArgIle: 4.489 ± 0.057	2.264ArgLys: 2.264 ± 0.043	8.972ArgLeu: 8.972 ± 0.095	1.92ArgMet: 1.92 ± 0.038	2.03ArgAsn: 2.03 ± 0.037	4.179ArgPro: 4.179 ± 0.057	2.596ArgGln: 2.596 ± 0.047	6.844ArgArg: 6.844 ± 0.085	3.476ArgSer: 3.476 ± 0.044	3.381ArgThr: 3.381 ± 0.051	5.126ArgVal: 5.126 ± 0.062	0.997ArgTrp: 0.997 ± 0.027	1.945ArgTyr: 1.945 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.763SerAla: 5.763 ± 0.068	0.399SerCys: 0.399 ± 0.017	2.823SerAsp: 2.823 ± 0.045	2.7SerGlu: 2.7 ± 0.047	2.158SerPhe: 2.158 ± 0.041	5.66SerGly: 5.66 ± 0.067	1.053SerHis: 1.053 ± 0.029	2.47SerIle: 2.47 ± 0.047	1.255SerLys: 1.255 ± 0.029	5.282SerLeu: 5.282 ± 0.068	1.234SerMet: 1.234 ± 0.029	1.164SerAsn: 1.164 ± 0.031	2.551SerPro: 2.551 ± 0.038	1.22SerGln: 1.22 ± 0.026	3.618SerArg: 3.618 ± 0.045	2.356SerSer: 2.356 ± 0.048	2.312SerThr: 2.312 ± 0.045	3.676SerVal: 3.676 ± 0.054	0.668SerTrp: 0.668 ± 0.024	1.205SerTyr: 1.205 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.185ThrAla: 6.185 ± 0.069	0.409ThrCys: 0.409 ± 0.016	2.62ThrAsp: 2.62 ± 0.05	2.539ThrGlu: 2.539 ± 0.045	1.76ThrPhe: 1.76 ± 0.038	5.098ThrGly: 5.098 ± 0.062	0.827ThrHis: 0.827 ± 0.023	2.721ThrIle: 2.721 ± 0.042	0.982ThrLys: 0.982 ± 0.027	5.51ThrLeu: 5.51 ± 0.067	1.197ThrMet: 1.197 ± 0.027	1.061ThrAsn: 1.061 ± 0.026	2.95ThrPro: 2.95 ± 0.047	1.094ThrGln: 1.094 ± 0.026	3.276ThrArg: 3.276 ± 0.047	2.325ThrSer: 2.325 ± 0.044	2.616ThrThr: 2.616 ± 0.049	4.448ThrVal: 4.448 ± 0.058	0.581ThrTrp: 0.581 ± 0.018	1.059ThrTyr: 1.059 ± 0.026	0.0ThrXaa: 0.0 ± 0.0
Val	9.943ValAla: 9.943 ± 0.097	0.657ValCys: 0.657 ± 0.023	4.41ValAsp: 4.41 ± 0.059	4.679ValGlu: 4.679 ± 0.062	2.725ValPhe: 2.725 ± 0.046	5.952ValGly: 5.952 ± 0.077	1.393ValHis: 1.393 ± 0.035	4.01ValIle: 4.01 ± 0.049	1.816ValLys: 1.816 ± 0.037	7.389ValLeu: 7.389 ± 0.079	1.863ValMet: 1.863 ± 0.039	2.018ValAsn: 2.018 ± 0.037	3.827ValPro: 3.827 ± 0.054	1.756ValGln: 1.756 ± 0.037	5.302ValArg: 5.302 ± 0.062	4.01ValSer: 4.01 ± 0.054	4.389ValThr: 4.389 ± 0.066	6.103ValVal: 6.103 ± 0.074	0.855ValTrp: 0.855 ± 0.024	1.53ValTyr: 1.53 ± 0.026	0.0ValXaa: 0.0 ± 0.0
Trp	1.181TrpAla: 1.181 ± 0.028	0.15TrpCys: 0.15 ± 0.011	0.623TrpAsp: 0.623 ± 0.023	0.585TrpGlu: 0.585 ± 0.022	0.518TrpPhe: 0.518 ± 0.019	0.859TrpGly: 0.859 ± 0.026	0.334TrpHis: 0.334 ± 0.015	0.65TrpIle: 0.65 ± 0.022	0.381TrpLys: 0.381 ± 0.016	1.708TrpLeu: 1.708 ± 0.037	0.318TrpMet: 0.318 ± 0.016	0.397TrpAsn: 0.397 ± 0.017	0.781TrpPro: 0.781 ± 0.023	0.584TrpGln: 0.584 ± 0.021	1.295TrpArg: 1.295 ± 0.028	0.736TrpSer: 0.736 ± 0.023	0.673TrpThr: 0.673 ± 0.024	0.732TrpVal: 0.732 ± 0.024	0.183TrpTrp: 0.183 ± 0.012	0.317TrpTyr: 0.317 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.297TyrAla: 2.297 ± 0.043	0.262TyrCys: 0.262 ± 0.012	1.447TyrAsp: 1.447 ± 0.031	1.199TyrGlu: 1.199 ± 0.027	0.976TyrPhe: 0.976 ± 0.026	2.184TyrGly: 2.184 ± 0.04	0.515TyrHis: 0.515 ± 0.019	0.813TyrIle: 0.813 ± 0.024	0.556TyrLys: 0.556 ± 0.018	2.555TyrLeu: 2.555 ± 0.04	0.496TyrMet: 0.496 ± 0.017	0.559TyrAsn: 0.559 ± 0.021	1.142TyrPro: 1.142 ± 0.032	0.642TyrGln: 0.642 ± 0.024	2.159TyrArg: 2.159 ± 0.04	1.187TyrSer: 1.187 ± 0.029	0.924TyrThr: 0.924 ± 0.026	1.632TyrVal: 1.632 ± 0.032	0.425TyrTrp: 0.425 ± 0.017	0.636TyrTyr: 0.636 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4524 proteins (1462766 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---