Amino acid dipepetide frequency for cyanobiont of Ornithocercus magnificus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.412AlaAla: 10.412 ± 0.203
1.582AlaCys: 1.582 ± 0.066
4.571AlaAsp: 4.571 ± 0.092
5.481AlaGlu: 5.481 ± 0.123
2.851AlaPhe: 2.851 ± 0.069
7.146AlaGly: 7.146 ± 0.153
1.649AlaHis: 1.649 ± 0.059
5.474AlaIle: 5.474 ± 0.107
2.861AlaLys: 2.861 ± 0.09
11.382AlaLeu: 11.382 ± 0.176
2.27AlaMet: 2.27 ± 0.069
2.638AlaAsn: 2.638 ± 0.086
3.558AlaPro: 3.558 ± 0.091
3.237AlaGln: 3.237 ± 0.097
5.879AlaArg: 5.879 ± 0.121
6.2AlaSer: 6.2 ± 0.103
4.596AlaThr: 4.596 ± 0.091
6.972AlaVal: 6.972 ± 0.134
1.385AlaTrp: 1.385 ± 0.057
1.992AlaTyr: 1.992 ± 0.067
0.0AlaXaa: 0.0 ± 0.0
Cys
1.012CysAla: 1.012 ± 0.044
0.458CysCys: 0.458 ± 0.029
0.76CysAsp: 0.76 ± 0.041
0.717CysGlu: 0.717 ± 0.036
0.617CysPhe: 0.617 ± 0.035
1.41CysGly: 1.41 ± 0.058
0.476CysHis: 0.476 ± 0.029
0.727CysIle: 0.727 ± 0.036
0.435CysLys: 0.435 ± 0.028
1.929CysLeu: 1.929 ± 0.068
0.262CysMet: 0.262 ± 0.021
0.529CysAsn: 0.529 ± 0.032
0.868CysPro: 0.868 ± 0.042
0.615CysGln: 0.615 ± 0.033
1.338CysArg: 1.338 ± 0.054
1.153CysSer: 1.153 ± 0.049
0.697CysThr: 0.697 ± 0.042
0.728CysVal: 0.728 ± 0.038
0.419CysTrp: 0.419 ± 0.028
0.409CysTyr: 0.409 ± 0.028
0.0CysXaa: 0.0 ± 0.0
Asp
3.997AspAla: 3.997 ± 0.09
0.785AspCys: 0.785 ± 0.044
2.127AspAsp: 2.127 ± 0.077
2.532AspGlu: 2.532 ± 0.066
1.567AspPhe: 1.567 ± 0.062
3.766AspGly: 3.766 ± 0.094
1.097AspHis: 1.097 ± 0.044
2.624AspIle: 2.624 ± 0.079
1.522AspLys: 1.522 ± 0.066
6.866AspLeu: 6.866 ± 0.13
0.869AspMet: 0.869 ± 0.041
1.496AspAsn: 1.496 ± 0.057
3.037AspPro: 3.037 ± 0.079
2.066AspGln: 2.066 ± 0.057
3.388AspArg: 3.388 ± 0.085
3.2AspSer: 3.2 ± 0.085
2.142AspThr: 2.142 ± 0.069
3.071AspVal: 3.071 ± 0.084
1.028AspTrp: 1.028 ± 0.048
1.351AspTyr: 1.351 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
5.883GluAla: 5.883 ± 0.109
0.572GluCys: 0.572 ± 0.032
2.579GluAsp: 2.579 ± 0.097
3.505GluGlu: 3.505 ± 0.093
1.48GluPhe: 1.48 ± 0.05
3.768GluGly: 3.768 ± 0.096
1.285GluHis: 1.285 ± 0.05
3.112GluIle: 3.112 ± 0.088
2.015GluLys: 2.015 ± 0.079
7.381GluLeu: 7.381 ± 0.131
1.083GluMet: 1.083 ± 0.046
1.48GluAsn: 1.48 ± 0.055
2.544GluPro: 2.544 ± 0.063
2.996GluGln: 2.996 ± 0.079
4.504GluArg: 4.504 ± 0.093
3.186GluSer: 3.186 ± 0.084
2.663GluThr: 2.663 ± 0.064
3.997GluVal: 3.997 ± 0.088
0.703GluTrp: 0.703 ± 0.038
0.924GluTyr: 0.924 ± 0.042
0.0GluXaa: 0.0 ± 0.0
Phe
2.763PheAla: 2.763 ± 0.073
0.601PheCys: 0.601 ± 0.039
1.976PheAsp: 1.976 ± 0.06
1.665PheGlu: 1.665 ± 0.06
1.126PhePhe: 1.126 ± 0.052
2.775PheGly: 2.775 ± 0.081
0.768PheHis: 0.768 ± 0.041
1.576PheIle: 1.576 ± 0.056
0.887PheLys: 0.887 ± 0.049
3.572PheLeu: 3.572 ± 0.092
0.584PheMet: 0.584 ± 0.036
1.208PheAsn: 1.208 ± 0.059
1.488PhePro: 1.488 ± 0.052
1.289PheGln: 1.289 ± 0.051
2.189PheArg: 2.189 ± 0.065
2.54PheSer: 2.54 ± 0.063
1.751PheThr: 1.751 ± 0.054
1.755PheVal: 1.755 ± 0.066
0.634PheTrp: 0.634 ± 0.038
0.838PheTyr: 0.838 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
5.828GlyAla: 5.828 ± 0.116
1.457GlyCys: 1.457 ± 0.055
3.462GlyAsp: 3.462 ± 0.086
3.778GlyGlu: 3.778 ± 0.087
3.092GlyPhe: 3.092 ± 0.083
5.521GlyGly: 5.521 ± 0.14
1.796GlyHis: 1.796 ± 0.059
4.888GlyIle: 4.888 ± 0.102
2.783GlyLys: 2.783 ± 0.081
9.324GlyLeu: 9.324 ± 0.166
1.702GlyMet: 1.702 ± 0.067
2.325GlyAsn: 2.325 ± 0.069
2.9GlyPro: 2.9 ± 0.076
3.208GlyGln: 3.208 ± 0.083
5.36GlyArg: 5.36 ± 0.098
5.501GlySer: 5.501 ± 0.102
3.926GlyThr: 3.926 ± 0.091
4.955GlyVal: 4.955 ± 0.11
1.428GlyTrp: 1.428 ± 0.058
2.041GlyTyr: 2.041 ± 0.064
0.0GlyXaa: 0.0 ± 0.0
His
1.655HisAla: 1.655 ± 0.058
0.511HisCys: 0.511 ± 0.032
0.973HisAsp: 0.973 ± 0.039
0.956HisGlu: 0.956 ± 0.047
0.887HisPhe: 0.887 ± 0.04
1.727HisGly: 1.727 ± 0.054
0.903HisHis: 0.903 ± 0.05
1.181HisIle: 1.181 ± 0.051
0.611HisLys: 0.611 ± 0.038
3.01HisLeu: 3.01 ± 0.095
0.368HisMet: 0.368 ± 0.028
0.869HisAsn: 0.869 ± 0.042
1.39HisPro: 1.39 ± 0.055
1.095HisGln: 1.095 ± 0.048
1.962HisArg: 1.962 ± 0.074
1.633HisSer: 1.633 ± 0.062
0.999HisThr: 0.999 ± 0.046
1.191HisVal: 1.191 ± 0.055
0.597HisTrp: 0.597 ± 0.034
0.656HisTyr: 0.656 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.599IleAla: 5.599 ± 0.099
0.956IleCys: 0.956 ± 0.05
3.2IleAsp: 3.2 ± 0.08
3.325IleGlu: 3.325 ± 0.086
1.747IlePhe: 1.747 ± 0.063
4.559IleGly: 4.559 ± 0.118
1.226IleHis: 1.226 ± 0.058
2.567IleIle: 2.567 ± 0.075
1.667IleLys: 1.667 ± 0.067
5.256IleLeu: 5.256 ± 0.127
0.728IleMet: 0.728 ± 0.036
2.084IleAsn: 2.084 ± 0.068
2.922IlePro: 2.922 ± 0.083
1.999IleGln: 1.999 ± 0.062
3.472IleArg: 3.472 ± 0.077
4.269IleSer: 4.269 ± 0.088
3.257IleThr: 3.257 ± 0.09
3.419IleVal: 3.419 ± 0.091
0.858IleTrp: 0.858 ± 0.04
1.263IleTyr: 1.263 ± 0.049
0.0IleXaa: 0.0 ± 0.0
Lys
3.169LysAla: 3.169 ± 0.087
0.36LysCys: 0.36 ± 0.029
1.516LysAsp: 1.516 ± 0.066
1.766LysGlu: 1.766 ± 0.07
0.854LysPhe: 0.854 ± 0.046
2.14LysGly: 2.14 ± 0.07
0.719LysHis: 0.719 ± 0.036
1.698LysIle: 1.698 ± 0.067
1.173LysLys: 1.173 ± 0.072
3.981LysLeu: 3.981 ± 0.104
0.505LysMet: 0.505 ± 0.034
0.948LysAsn: 0.948 ± 0.043
1.884LysPro: 1.884 ± 0.067
1.674LysGln: 1.674 ± 0.062
2.565LysArg: 2.565 ± 0.085
2.041LysSer: 2.041 ± 0.067
1.782LysThr: 1.782 ± 0.063
2.207LysVal: 2.207 ± 0.08
0.294LysTrp: 0.294 ± 0.028
0.656LysTyr: 0.656 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
12.567LeuAla: 12.567 ± 0.182
1.651LeuCys: 1.651 ± 0.057
6.083LeuAsp: 6.083 ± 0.122
8.062LeuGlu: 8.062 ± 0.136
3.378LeuPhe: 3.378 ± 0.091
9.1LeuGly: 9.1 ± 0.158
2.822LeuHis: 2.822 ± 0.086
6.639LeuIle: 6.639 ± 0.138
4.118LeuLys: 4.118 ± 0.094
15.831LeuLeu: 15.831 ± 0.298
2.554LeuMet: 2.554 ± 0.073
3.807LeuAsn: 3.807 ± 0.088
6.895LeuPro: 6.895 ± 0.127
6.13LeuGln: 6.13 ± 0.121
8.883LeuArg: 8.883 ± 0.168
8.623LeuSer: 8.623 ± 0.139
6.116LeuThr: 6.116 ± 0.124
8.801LeuVal: 8.801 ± 0.154
1.717LeuTrp: 1.717 ± 0.065
2.274LeuTyr: 2.274 ± 0.066
0.0LeuXaa: 0.0 ± 0.0
Met
2.454MetAla: 2.454 ± 0.068
0.176MetCys: 0.176 ± 0.019
0.785MetAsp: 0.785 ± 0.04
1.016MetGlu: 1.016 ± 0.048
0.48MetPhe: 0.48 ± 0.029
1.496MetGly: 1.496 ± 0.058
0.429MetHis: 0.429 ± 0.03
0.967MetIle: 0.967 ± 0.043
0.681MetLys: 0.681 ± 0.038
2.454MetLeu: 2.454 ± 0.066
0.392MetMet: 0.392 ± 0.027
0.576MetAsn: 0.576 ± 0.034
1.236MetPro: 1.236 ± 0.049
0.883MetGln: 0.883 ± 0.04
1.316MetArg: 1.316 ± 0.049
1.408MetSer: 1.408 ± 0.055
1.259MetThr: 1.259 ± 0.051
1.51MetVal: 1.51 ± 0.056
0.141MetTrp: 0.141 ± 0.017
0.29MetTyr: 0.29 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
2.655AsnAla: 2.655 ± 0.079
0.578AsnCys: 0.578 ± 0.032
1.326AsnAsp: 1.326 ± 0.056
1.292AsnGlu: 1.292 ± 0.056
1.144AsnPhe: 1.144 ± 0.049
2.195AsnGly: 2.195 ± 0.067
0.789AsnHis: 0.789 ± 0.044
1.723AsnIle: 1.723 ± 0.059
0.969AsnLys: 0.969 ± 0.054
4.187AsnLeu: 4.187 ± 0.1
0.58AsnMet: 0.58 ± 0.034
1.2AsnAsn: 1.2 ± 0.05
2.09AsnPro: 2.09 ± 0.069
1.418AsnGln: 1.418 ± 0.057
2.325AsnArg: 2.325 ± 0.064
2.373AsnSer: 2.373 ± 0.072
1.52AsnThr: 1.52 ± 0.058
1.755AsnVal: 1.755 ± 0.053
0.687AsnTrp: 0.687 ± 0.039
0.887AsnTyr: 0.887 ± 0.045
0.0AsnXaa: 0.0 ± 0.0
Pro
4.308ProAla: 4.308 ± 0.095
0.68ProCys: 0.68 ± 0.037
2.845ProAsp: 2.845 ± 0.076
3.439ProGlu: 3.439 ± 0.081
1.712ProPhe: 1.712 ± 0.065
4.013ProGly: 4.013 ± 0.088
1.042ProHis: 1.042 ± 0.047
2.695ProIle: 2.695 ± 0.076
1.678ProLys: 1.678 ± 0.061
6.255ProLeu: 6.255 ± 0.132
1.059ProMet: 1.059 ± 0.048
1.571ProAsn: 1.571 ± 0.056
2.295ProPro: 2.295 ± 0.07
1.964ProGln: 1.964 ± 0.064
2.773ProArg: 2.773 ± 0.073
3.498ProSer: 3.498 ± 0.093
2.644ProThr: 2.644 ± 0.069
3.834ProVal: 3.834 ± 0.086
0.924ProTrp: 0.924 ± 0.044
1.183ProTyr: 1.183 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
4.25GlnAla: 4.25 ± 0.089
0.49GlnCys: 0.49 ± 0.033
1.78GlnAsp: 1.78 ± 0.064
2.55GlnGlu: 2.55 ± 0.074
1.159GlnPhe: 1.159 ± 0.043
2.969GlnGly: 2.969 ± 0.076
1.13GlnHis: 1.13 ± 0.047
2.33GlnIle: 2.33 ± 0.06
1.445GlnLys: 1.445 ± 0.055
6.443GlnLeu: 6.443 ± 0.131
0.772GlnMet: 0.772 ± 0.04
1.091GlnAsn: 1.091 ± 0.045
2.319GlnPro: 2.319 ± 0.068
2.726GlnGln: 2.726 ± 0.079
3.968GlnArg: 3.968 ± 0.09
2.605GlnSer: 2.605 ± 0.074
1.733GlnThr: 1.733 ± 0.056
3.345GlnVal: 3.345 ± 0.085
0.607GlnTrp: 0.607 ± 0.033
0.805GlnTyr: 0.805 ± 0.034
0.0GlnXaa: 0.0 ± 0.0
Arg
5.217ArgAla: 5.217 ± 0.11
1.289ArgCys: 1.289 ± 0.055
3.339ArgAsp: 3.339 ± 0.087
3.876ArgGlu: 3.876 ± 0.095
2.534ArgPhe: 2.534 ± 0.073
4.549ArgGly: 4.549 ± 0.093
1.988ArgHis: 1.988 ± 0.072
3.731ArgIle: 3.731 ± 0.085
2.103ArgLys: 2.103 ± 0.068
9.803ArgLeu: 9.803 ± 0.155
1.363ArgMet: 1.363 ± 0.049
2.229ArgAsn: 2.229 ± 0.064
3.458ArgPro: 3.458 ± 0.101
4.126ArgGln: 4.126 ± 0.096
6.188ArgArg: 6.188 ± 0.122
4.794ArgSer: 4.794 ± 0.102
3.0ArgThr: 3.0 ± 0.075
4.253ArgVal: 4.253 ± 0.09
1.547ArgTrp: 1.547 ± 0.064
1.913ArgTyr: 1.913 ± 0.063
0.0ArgXaa: 0.0 ± 0.0
Ser
5.464SerAla: 5.464 ± 0.102
1.191SerCys: 1.191 ± 0.047
3.427SerAsp: 3.427 ± 0.096
3.605SerGlu: 3.605 ± 0.078
2.35SerPhe: 2.35 ± 0.065
5.94SerGly: 5.94 ± 0.11
1.616SerHis: 1.616 ± 0.055
3.644SerIle: 3.644 ± 0.078
2.256SerLys: 2.256 ± 0.081
8.773SerLeu: 8.773 ± 0.172
1.571SerMet: 1.571 ± 0.062
2.424SerAsn: 2.424 ± 0.065
3.149SerPro: 3.149 ± 0.081
2.912SerGln: 2.912 ± 0.071
4.837SerArg: 4.837 ± 0.108
5.742SerSer: 5.742 ± 0.126
3.689SerThr: 3.689 ± 0.094
4.22SerVal: 4.22 ± 0.087
1.5SerTrp: 1.5 ± 0.061
1.739SerTyr: 1.739 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
5.239ThrAla: 5.239 ± 0.1
0.629ThrCys: 0.629 ± 0.035
2.399ThrAsp: 2.399 ± 0.077
2.561ThrGlu: 2.561 ± 0.074
1.48ThrPhe: 1.48 ± 0.049
4.091ThrGly: 4.091 ± 0.103
0.928ThrHis: 0.928 ± 0.044
2.793ThrIle: 2.793 ± 0.081
1.459ThrLys: 1.459 ± 0.056
5.985ThrLeu: 5.985 ± 0.116
1.063ThrMet: 1.063 ± 0.044
1.688ThrAsn: 1.688 ± 0.052
2.963ThrPro: 2.963 ± 0.08
1.643ThrGln: 1.643 ± 0.063
2.748ThrArg: 2.748 ± 0.085
3.742ThrSer: 3.742 ± 0.075
3.114ThrThr: 3.114 ± 0.089
3.817ThrVal: 3.817 ± 0.097
0.668ThrTrp: 0.668 ± 0.036
1.23ThrTyr: 1.23 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
6.68ValAla: 6.68 ± 0.114
0.873ValCys: 0.873 ± 0.044
3.592ValAsp: 3.592 ± 0.087
3.862ValGlu: 3.862 ± 0.101
2.15ValPhe: 2.15 ± 0.071
4.966ValGly: 4.966 ± 0.094
1.512ValHis: 1.512 ± 0.056
3.997ValIle: 3.997 ± 0.091
2.039ValLys: 2.039 ± 0.065
8.209ValLeu: 8.209 ± 0.18
1.465ValMet: 1.465 ± 0.051
2.268ValAsn: 2.268 ± 0.064
3.282ValPro: 3.282 ± 0.083
2.497ValGln: 2.497 ± 0.075
4.334ValArg: 4.334 ± 0.091
4.59ValSer: 4.59 ± 0.102
3.666ValThr: 3.666 ± 0.092
5.554ValVal: 5.554 ± 0.11
0.913ValTrp: 0.913 ± 0.041
1.218ValTyr: 1.218 ± 0.048
0.0ValXaa: 0.0 ± 0.0
Trp
1.132TrpAla: 1.132 ± 0.052
0.276TrpCys: 0.276 ± 0.024
0.634TrpAsp: 0.634 ± 0.041
0.631TrpGlu: 0.631 ± 0.034
0.634TrpPhe: 0.634 ± 0.038
1.016TrpGly: 1.016 ± 0.04
0.48TrpHis: 0.48 ± 0.032
0.928TrpIle: 0.928 ± 0.043
0.497TrpLys: 0.497 ± 0.03
2.763TrpLeu: 2.763 ± 0.094
0.36TrpMet: 0.36 ± 0.029
0.531TrpAsn: 0.531 ± 0.031
0.881TrpPro: 0.881 ± 0.043
1.042TrpGln: 1.042 ± 0.048
1.426TrpArg: 1.426 ± 0.062
1.265TrpSer: 1.265 ± 0.051
0.656TrpThr: 0.656 ± 0.038
1.034TrpVal: 1.034 ± 0.042
0.366TrpTrp: 0.366 ± 0.03
0.37TrpTyr: 0.37 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.853TyrAla: 1.853 ± 0.062
0.445TyrCys: 0.445 ± 0.03
1.157TyrAsp: 1.157 ± 0.045
1.042TyrGlu: 1.042 ± 0.048
0.742TyrPhe: 0.742 ± 0.044
2.125TyrGly: 2.125 ± 0.072
0.523TyrHis: 0.523 ± 0.035
1.079TyrIle: 1.079 ± 0.044
0.732TyrLys: 0.732 ± 0.043
2.646TyrLeu: 2.646 ± 0.08
0.398TyrMet: 0.398 ± 0.03
0.732TyrAsn: 0.732 ± 0.043
1.251TyrPro: 1.251 ± 0.056
0.995TyrGln: 0.995 ± 0.041
1.849TyrArg: 1.849 ± 0.067
1.686TyrSer: 1.686 ± 0.055
1.028TyrThr: 1.028 ± 0.044
1.249TyrVal: 1.249 ± 0.043
0.507TyrTrp: 0.507 ± 0.031
0.539TyrTyr: 0.539 ± 0.033
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1841 proteins (510641 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski