Amino acid dipepetide frequency for Klebsiella quasipneumoniae subsp. similipneumoniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.456AlaAla: 11.456 ± 0.136
1.15AlaCys: 1.15 ± 0.027
5.486AlaAsp: 5.486 ± 0.068
5.919AlaGlu: 5.919 ± 0.074
3.938AlaPhe: 3.938 ± 0.06
8.379AlaGly: 8.379 ± 0.094
2.23AlaHis: 2.23 ± 0.043
5.927AlaIle: 5.927 ± 0.076
3.597AlaLys: 3.597 ± 0.068
12.064AlaLeu: 12.064 ± 0.116
3.076AlaMet: 3.076 ± 0.047
2.966AlaAsn: 2.966 ± 0.05
3.817AlaPro: 3.817 ± 0.054
4.695AlaGln: 4.695 ± 0.077
6.209AlaArg: 6.209 ± 0.093
5.461AlaSer: 5.461 ± 0.075
4.634AlaThr: 4.634 ± 0.07
7.479AlaVal: 7.479 ± 0.09
1.68AlaTrp: 1.68 ± 0.036
1.877AlaTyr: 1.877 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
1.072CysAla: 1.072 ± 0.028
0.212CysCys: 0.212 ± 0.013
0.565CysAsp: 0.565 ± 0.024
0.582CysGlu: 0.582 ± 0.021
0.473CysPhe: 0.473 ± 0.021
1.028CysGly: 1.028 ± 0.031
0.339CysHis: 0.339 ± 0.015
0.565CysIle: 0.565 ± 0.021
0.351CysLys: 0.351 ± 0.019
1.025CysLeu: 1.025 ± 0.031
0.268CysMet: 0.268 ± 0.014
0.312CysAsn: 0.312 ± 0.015
0.528CysPro: 0.528 ± 0.025
0.505CysGln: 0.505 ± 0.022
0.744CysArg: 0.744 ± 0.025
0.686CysSer: 0.686 ± 0.024
0.473CysThr: 0.473 ± 0.02
0.754CysVal: 0.754 ± 0.027
0.186CysTrp: 0.186 ± 0.013
0.326CysTyr: 0.326 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
5.221AspAla: 5.221 ± 0.074
0.499AspCys: 0.499 ± 0.02
3.019AspAsp: 3.019 ± 0.061
3.357AspGlu: 3.357 ± 0.062
2.152AspPhe: 2.152 ± 0.046
3.823AspGly: 3.823 ± 0.057
1.285AspHis: 1.285 ± 0.034
3.371AspIle: 3.371 ± 0.052
2.478AspLys: 2.478 ± 0.05
4.696AspLeu: 4.696 ± 0.063
1.34AspMet: 1.34 ± 0.039
2.121AspAsn: 2.121 ± 0.045
2.284AspPro: 2.284 ± 0.04
1.749AspGln: 1.749 ± 0.04
3.018AspArg: 3.018 ± 0.058
2.711AspSer: 2.711 ± 0.049
2.362AspThr: 2.362 ± 0.04
3.659AspVal: 3.659 ± 0.061
0.73AspTrp: 0.73 ± 0.025
1.768AspTyr: 1.768 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
5.526GluAla: 5.526 ± 0.075
0.46GluCys: 0.46 ± 0.022
2.324GluAsp: 2.324 ± 0.049
3.285GluGlu: 3.285 ± 0.067
1.752GluPhe: 1.752 ± 0.035
3.592GluGly: 3.592 ± 0.055
1.399GluHis: 1.399 ± 0.032
3.117GluIle: 3.117 ± 0.055
2.984GluLys: 2.984 ± 0.06
5.55GluLeu: 5.55 ± 0.072
1.76GluMet: 1.76 ± 0.042
2.089GluAsn: 2.089 ± 0.045
1.974GluPro: 1.974 ± 0.043
3.161GluGln: 3.161 ± 0.051
3.646GluArg: 3.646 ± 0.061
2.815GluSer: 2.815 ± 0.051
2.751GluThr: 2.751 ± 0.05
3.718GluVal: 3.718 ± 0.052
0.772GluTrp: 0.772 ± 0.028
1.37GluTyr: 1.37 ± 0.038
0.0GluXaa: 0.0 ± 0.0
Phe
4.093PheAla: 4.093 ± 0.058
0.57PheCys: 0.57 ± 0.022
2.431PheAsp: 2.431 ± 0.053
1.649PheGlu: 1.649 ± 0.041
1.911PhePhe: 1.911 ± 0.05
3.236PheGly: 3.236 ± 0.061
1.011PheHis: 1.011 ± 0.036
2.687PheIle: 2.687 ± 0.051
1.299PheLys: 1.299 ± 0.032
3.423PheLeu: 3.423 ± 0.064
0.994PheMet: 0.994 ± 0.031
1.698PheAsn: 1.698 ± 0.038
1.551PhePro: 1.551 ± 0.038
1.32PheGln: 1.32 ± 0.039
2.266PheArg: 2.266 ± 0.046
3.109PheSer: 3.109 ± 0.051
2.56PheThr: 2.56 ± 0.043
2.665PheVal: 2.665 ± 0.056
0.638PheTrp: 0.638 ± 0.022
1.224PheTyr: 1.224 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
6.563GlyAla: 6.563 ± 0.085
0.986GlyCys: 0.986 ± 0.025
4.076GlyAsp: 4.076 ± 0.069
4.622GlyGlu: 4.622 ± 0.076
3.552GlyPhe: 3.552 ± 0.06
5.788GlyGly: 5.788 ± 0.072
1.843GlyHis: 1.843 ± 0.04
4.916GlyIle: 4.916 ± 0.07
3.72GlyLys: 3.72 ± 0.061
7.612GlyLeu: 7.612 ± 0.088
2.417GlyMet: 2.417 ± 0.049
2.593GlyAsn: 2.593 ± 0.049
2.067GlyPro: 2.067 ± 0.043
3.102GlyGln: 3.102 ± 0.052
4.087GlyArg: 4.087 ± 0.061
3.926GlySer: 3.926 ± 0.058
3.43GlyThr: 3.43 ± 0.049
6.079GlyVal: 6.079 ± 0.076
1.274GlyTrp: 1.274 ± 0.033
2.551GlyTyr: 2.551 ± 0.058
0.0GlyXaa: 0.0 ± 0.0
His
2.244HisAla: 2.244 ± 0.046
0.324HisCys: 0.324 ± 0.015
1.268HisAsp: 1.268 ± 0.028
1.038HisGlu: 1.038 ± 0.027
1.282HisPhe: 1.282 ± 0.035
1.891HisGly: 1.891 ± 0.039
1.141HisHis: 1.141 ± 0.041
1.463HisIle: 1.463 ± 0.034
0.781HisLys: 0.781 ± 0.025
2.517HisLeu: 2.517 ± 0.05
0.552HisMet: 0.552 ± 0.02
0.782HisAsn: 0.782 ± 0.022
1.528HisPro: 1.528 ± 0.036
1.537HisGln: 1.537 ± 0.04
1.863HisArg: 1.863 ± 0.05
1.301HisSer: 1.301 ± 0.031
1.094HisThr: 1.094 ± 0.034
1.487HisVal: 1.487 ± 0.035
0.395HisTrp: 0.395 ± 0.019
0.892HisTyr: 0.892 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.739IleAla: 6.739 ± 0.089
0.671IleCys: 0.671 ± 0.022
3.524IleAsp: 3.524 ± 0.06
3.068IleGlu: 3.068 ± 0.055
2.167IlePhe: 2.167 ± 0.043
4.649IleGly: 4.649 ± 0.068
1.306IleHis: 1.306 ± 0.036
3.177IleIle: 3.177 ± 0.062
2.301IleLys: 2.301 ± 0.046
4.966IleLeu: 4.966 ± 0.071
1.252IleMet: 1.252 ± 0.033
2.408IleAsn: 2.408 ± 0.049
2.703IlePro: 2.703 ± 0.046
1.824IleGln: 1.824 ± 0.039
3.007IleArg: 3.007 ± 0.05
3.514IleSer: 3.514 ± 0.06
3.172IleThr: 3.172 ± 0.048
4.001IleVal: 4.001 ± 0.066
0.675IleTrp: 0.675 ± 0.023
1.415IleTyr: 1.415 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.212LysAla: 4.212 ± 0.074
0.289LysCys: 0.289 ± 0.017
1.842LysAsp: 1.842 ± 0.047
2.237LysGlu: 2.237 ± 0.05
1.072LysPhe: 1.072 ± 0.029
2.791LysGly: 2.791 ± 0.053
0.867LysHis: 0.867 ± 0.025
2.28LysIle: 2.28 ± 0.056
2.2LysLys: 2.2 ± 0.052
4.0LysLeu: 4.0 ± 0.064
1.295LysMet: 1.295 ± 0.034
1.583LysAsn: 1.583 ± 0.041
1.94LysPro: 1.94 ± 0.045
1.887LysGln: 1.887 ± 0.042
2.533LysArg: 2.533 ± 0.05
2.119LysSer: 2.119 ± 0.043
2.356LysThr: 2.356 ± 0.05
2.852LysVal: 2.852 ± 0.049
0.414LysTrp: 0.414 ± 0.02
1.074LysTyr: 1.074 ± 0.031
0.0LysXaa: 0.0 ± 0.0
Leu
11.887LeuAla: 11.887 ± 0.115
1.318LeuCys: 1.318 ± 0.037
5.133LeuAsp: 5.133 ± 0.07
5.162LeuGlu: 5.162 ± 0.074
4.479LeuPhe: 4.479 ± 0.073
7.268LeuGly: 7.268 ± 0.095
2.493LeuHis: 2.493 ± 0.047
5.755LeuIle: 5.755 ± 0.073
4.174LeuLys: 4.174 ± 0.065
12.208LeuLeu: 12.208 ± 0.143
2.904LeuMet: 2.904 ± 0.052
3.956LeuAsn: 3.956 ± 0.057
5.622LeuPro: 5.622 ± 0.065
4.578LeuGln: 4.578 ± 0.069
6.81LeuArg: 6.81 ± 0.079
6.919LeuSer: 6.919 ± 0.092
6.161LeuThr: 6.161 ± 0.073
7.019LeuVal: 7.019 ± 0.086
1.436LeuTrp: 1.436 ± 0.037
2.437LeuTyr: 2.437 ± 0.047
0.0LeuXaa: 0.0 ± 0.0
Met
3.077MetAla: 3.077 ± 0.051
0.209MetCys: 0.209 ± 0.013
1.096MetAsp: 1.096 ± 0.029
1.212MetGlu: 1.212 ± 0.032
0.91MetPhe: 0.91 ± 0.027
1.864MetGly: 1.864 ± 0.037
0.577MetHis: 0.577 ± 0.019
1.446MetIle: 1.446 ± 0.041
1.337MetLys: 1.337 ± 0.032
3.207MetLeu: 3.207 ± 0.056
0.883MetMet: 0.883 ± 0.028
1.097MetAsn: 1.097 ± 0.034
1.412MetPro: 1.412 ± 0.033
1.231MetGln: 1.231 ± 0.03
1.561MetArg: 1.561 ± 0.031
1.799MetSer: 1.799 ± 0.04
1.784MetThr: 1.784 ± 0.036
2.019MetVal: 2.019 ± 0.041
0.269MetTrp: 0.269 ± 0.013
0.51MetTyr: 0.51 ± 0.019
0.0MetXaa: 0.0 ± 0.0
Asn
3.213AsnAla: 3.213 ± 0.05
0.322AsnCys: 0.322 ± 0.016
1.966AsnAsp: 1.966 ± 0.041
1.781AsnGlu: 1.781 ± 0.037
1.275AsnPhe: 1.275 ± 0.034
2.842AsnGly: 2.842 ± 0.049
0.917AsnHis: 0.917 ± 0.028
2.174AsnIle: 2.174 ± 0.046
1.457AsnLys: 1.457 ± 0.041
3.219AsnLeu: 3.219 ± 0.05
0.91AsnMet: 0.91 ± 0.029
1.449AsnAsn: 1.449 ± 0.044
1.958AsnPro: 1.958 ± 0.04
1.486AsnGln: 1.486 ± 0.04
2.016AsnArg: 2.016 ± 0.039
1.869AsnSer: 1.869 ± 0.039
1.799AsnThr: 1.799 ± 0.046
2.459AsnVal: 2.459 ± 0.051
0.485AsnTrp: 0.485 ± 0.018
1.028AsnTyr: 1.028 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
4.983ProAla: 4.983 ± 0.065
0.41ProCys: 0.41 ± 0.016
2.631ProAsp: 2.631 ± 0.047
3.114ProGlu: 3.114 ± 0.054
1.916ProPhe: 1.916 ± 0.041
3.697ProGly: 3.697 ± 0.06
1.15ProHis: 1.15 ± 0.029
1.719ProIle: 1.719 ± 0.041
1.33ProLys: 1.33 ± 0.031
5.2ProLeu: 5.2 ± 0.067
1.09ProMet: 1.09 ± 0.031
1.159ProAsn: 1.159 ± 0.031
1.791ProPro: 1.791 ± 0.053
2.44ProGln: 2.44 ± 0.046
2.31ProArg: 2.31 ± 0.047
2.106ProSer: 2.106 ± 0.042
2.001ProThr: 2.001 ± 0.039
3.826ProVal: 3.826 ± 0.055
0.781ProTrp: 0.781 ± 0.028
1.104ProTyr: 1.104 ± 0.031
0.0ProXaa: 0.0 ± 0.0
Gln
4.952GlnAla: 4.952 ± 0.067
0.405GlnCys: 0.405 ± 0.02
1.693GlnAsp: 1.693 ± 0.04
2.032GlnGlu: 2.032 ± 0.042
1.567GlnPhe: 1.567 ± 0.036
3.22GlnGly: 3.22 ± 0.05
1.539GlnHis: 1.539 ± 0.04
2.331GlnIle: 2.331 ± 0.042
1.682GlnLys: 1.682 ± 0.044
5.204GlnLeu: 5.204 ± 0.073
1.248GlnMet: 1.248 ± 0.036
1.321GlnAsn: 1.321 ± 0.035
2.392GlnPro: 2.392 ± 0.047
3.49GlnGln: 3.49 ± 0.073
4.151GlnArg: 4.151 ± 0.073
2.132GlnSer: 2.132 ± 0.047
2.216GlnThr: 2.216 ± 0.044
3.113GlnVal: 3.113 ± 0.054
0.608GlnTrp: 0.608 ± 0.022
1.125GlnTyr: 1.125 ± 0.03
0.0GlnXaa: 0.0 ± 0.0
Arg
5.264ArgAla: 5.264 ± 0.074
0.678ArgCys: 0.678 ± 0.026
3.214ArgAsp: 3.214 ± 0.057
3.876ArgGlu: 3.876 ± 0.064
2.953ArgPhe: 2.953 ± 0.058
3.829ArgGly: 3.829 ± 0.056
2.101ArgHis: 2.101 ± 0.049
3.509ArgIle: 3.509 ± 0.058
2.385ArgLys: 2.385 ± 0.042
7.174ArgLeu: 7.174 ± 0.097
1.732ArgMet: 1.732 ± 0.037
1.922ArgAsn: 1.922 ± 0.047
2.658ArgPro: 2.658 ± 0.051
3.984ArgGln: 3.984 ± 0.073
4.868ArgArg: 4.868 ± 0.094
2.883ArgSer: 2.883 ± 0.051
2.571ArgThr: 2.571 ± 0.05
4.111ArgVal: 4.111 ± 0.064
1.025ArgTrp: 1.025 ± 0.029
2.147ArgTyr: 2.147 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
5.604SerAla: 5.604 ± 0.072
0.61SerCys: 0.61 ± 0.021
2.999SerAsp: 2.999 ± 0.05
2.981SerGlu: 2.981 ± 0.048
2.235SerPhe: 2.235 ± 0.045
5.002SerGly: 5.002 ± 0.07
1.404SerHis: 1.404 ± 0.032
2.89SerIle: 2.89 ± 0.053
1.945SerLys: 1.945 ± 0.042
6.348SerLeu: 6.348 ± 0.08
1.492SerMet: 1.492 ± 0.039
1.751SerAsn: 1.751 ± 0.04
2.673SerPro: 2.673 ± 0.05
2.435SerGln: 2.435 ± 0.045
3.543SerArg: 3.543 ± 0.051
3.397SerSer: 3.397 ± 0.071
2.715SerThr: 2.715 ± 0.051
4.006SerVal: 4.006 ± 0.063
0.954SerTrp: 0.954 ± 0.028
1.518SerTyr: 1.518 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
4.989ThrAla: 4.989 ± 0.079
0.52ThrCys: 0.52 ± 0.02
2.456ThrAsp: 2.456 ± 0.043
2.452ThrGlu: 2.452 ± 0.048
2.048ThrPhe: 2.048 ± 0.046
4.248ThrGly: 4.248 ± 0.054
1.228ThrHis: 1.228 ± 0.031
2.721ThrIle: 2.721 ± 0.048
1.434ThrLys: 1.434 ± 0.036
6.991ThrLeu: 6.991 ± 0.085
1.111ThrMet: 1.111 ± 0.033
1.376ThrAsn: 1.376 ± 0.035
2.937ThrPro: 2.937 ± 0.043
1.89ThrGln: 1.89 ± 0.041
3.138ThrArg: 3.138 ± 0.057
2.786ThrSer: 2.786 ± 0.054
2.784ThrThr: 2.784 ± 0.059
3.833ThrVal: 3.833 ± 0.054
0.814ThrTrp: 0.814 ± 0.026
1.138ThrTyr: 1.138 ± 0.031
0.0ThrXaa: 0.0 ± 0.0
Val
7.604ValAla: 7.604 ± 0.088
0.81ValCys: 0.81 ± 0.028
3.854ValAsp: 3.854 ± 0.055
3.954ValGlu: 3.954 ± 0.06
2.797ValPhe: 2.797 ± 0.053
5.138ValGly: 5.138 ± 0.074
1.358ValHis: 1.358 ± 0.037
4.429ValIle: 4.429 ± 0.064
3.01ValLys: 3.01 ± 0.052
7.089ValLeu: 7.089 ± 0.085
2.142ValMet: 2.142 ± 0.038
2.661ValAsn: 2.661 ± 0.048
2.945ValPro: 2.945 ± 0.047
2.532ValGln: 2.532 ± 0.045
3.991ValArg: 3.991 ± 0.064
4.523ValSer: 4.523 ± 0.059
4.051ValThr: 4.051 ± 0.058
5.784ValVal: 5.784 ± 0.086
0.98ValTrp: 0.98 ± 0.027
1.752ValTyr: 1.752 ± 0.04
0.0ValXaa: 0.0 ± 0.0
Trp
0.975TrpAla: 0.975 ± 0.029
0.183TrpCys: 0.183 ± 0.012
0.593TrpAsp: 0.593 ± 0.024
0.561TrpGlu: 0.561 ± 0.02
0.709TrpPhe: 0.709 ± 0.027
0.847TrpGly: 0.847 ± 0.028
0.463TrpHis: 0.463 ± 0.02
0.714TrpIle: 0.714 ± 0.025
0.503TrpLys: 0.503 ± 0.023
2.336TrpLeu: 2.336 ± 0.05
0.44TrpMet: 0.44 ± 0.02
0.483TrpAsn: 0.483 ± 0.023
0.654TrpPro: 0.654 ± 0.024
1.087TrpGln: 1.087 ± 0.031
1.203TrpArg: 1.203 ± 0.035
0.831TrpSer: 0.831 ± 0.024
0.605TrpThr: 0.605 ± 0.025
0.924TrpVal: 0.924 ± 0.027
0.231TrpTrp: 0.231 ± 0.015
0.407TrpTyr: 0.407 ± 0.018
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.366TyrAla: 2.366 ± 0.05
0.367TyrCys: 0.367 ± 0.017
1.476TyrAsp: 1.476 ± 0.04
1.163TyrGlu: 1.163 ± 0.032
1.147TyrPhe: 1.147 ± 0.033
2.071TyrGly: 2.071 ± 0.044
0.73TyrHis: 0.73 ± 0.023
1.348TyrIle: 1.348 ± 0.03
0.873TyrLys: 0.873 ± 0.028
2.891TyrLeu: 2.891 ± 0.049
0.592TyrMet: 0.592 ± 0.02
0.898TyrAsn: 0.898 ± 0.03
1.323TyrPro: 1.323 ± 0.035
1.488TyrGln: 1.488 ± 0.036
1.924TyrArg: 1.924 ± 0.04
1.613TyrSer: 1.613 ± 0.036
1.373TyrThr: 1.373 ± 0.038
1.617TyrVal: 1.617 ± 0.037
0.405TyrTrp: 0.405 ± 0.019
0.867TyrTyr: 0.867 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5434 proteins (1237787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski