Amino acid dipepetide frequency for Klebsiella quasipneumoniae subsp. similipneumoniae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.456AlaAla: 11.456 ± 0.136	1.15AlaCys: 1.15 ± 0.027	5.486AlaAsp: 5.486 ± 0.068	5.919AlaGlu: 5.919 ± 0.074	3.938AlaPhe: 3.938 ± 0.06	8.379AlaGly: 8.379 ± 0.094	2.23AlaHis: 2.23 ± 0.043	5.927AlaIle: 5.927 ± 0.076	3.597AlaLys: 3.597 ± 0.068	12.064AlaLeu: 12.064 ± 0.116	3.076AlaMet: 3.076 ± 0.047	2.966AlaAsn: 2.966 ± 0.05	3.817AlaPro: 3.817 ± 0.054	4.695AlaGln: 4.695 ± 0.077	6.209AlaArg: 6.209 ± 0.093	5.461AlaSer: 5.461 ± 0.075	4.634AlaThr: 4.634 ± 0.07	7.479AlaVal: 7.479 ± 0.09	1.68AlaTrp: 1.68 ± 0.036	1.877AlaTyr: 1.877 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	1.072CysAla: 1.072 ± 0.028	0.212CysCys: 0.212 ± 0.013	0.565CysAsp: 0.565 ± 0.024	0.582CysGlu: 0.582 ± 0.021	0.473CysPhe: 0.473 ± 0.021	1.028CysGly: 1.028 ± 0.031	0.339CysHis: 0.339 ± 0.015	0.565CysIle: 0.565 ± 0.021	0.351CysLys: 0.351 ± 0.019	1.025CysLeu: 1.025 ± 0.031	0.268CysMet: 0.268 ± 0.014	0.312CysAsn: 0.312 ± 0.015	0.528CysPro: 0.528 ± 0.025	0.505CysGln: 0.505 ± 0.022	0.744CysArg: 0.744 ± 0.025	0.686CysSer: 0.686 ± 0.024	0.473CysThr: 0.473 ± 0.02	0.754CysVal: 0.754 ± 0.027	0.186CysTrp: 0.186 ± 0.013	0.326CysTyr: 0.326 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	5.221AspAla: 5.221 ± 0.074	0.499AspCys: 0.499 ± 0.02	3.019AspAsp: 3.019 ± 0.061	3.357AspGlu: 3.357 ± 0.062	2.152AspPhe: 2.152 ± 0.046	3.823AspGly: 3.823 ± 0.057	1.285AspHis: 1.285 ± 0.034	3.371AspIle: 3.371 ± 0.052	2.478AspLys: 2.478 ± 0.05	4.696AspLeu: 4.696 ± 0.063	1.34AspMet: 1.34 ± 0.039	2.121AspAsn: 2.121 ± 0.045	2.284AspPro: 2.284 ± 0.04	1.749AspGln: 1.749 ± 0.04	3.018AspArg: 3.018 ± 0.058	2.711AspSer: 2.711 ± 0.049	2.362AspThr: 2.362 ± 0.04	3.659AspVal: 3.659 ± 0.061	0.73AspTrp: 0.73 ± 0.025	1.768AspTyr: 1.768 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	5.526GluAla: 5.526 ± 0.075	0.46GluCys: 0.46 ± 0.022	2.324GluAsp: 2.324 ± 0.049	3.285GluGlu: 3.285 ± 0.067	1.752GluPhe: 1.752 ± 0.035	3.592GluGly: 3.592 ± 0.055	1.399GluHis: 1.399 ± 0.032	3.117GluIle: 3.117 ± 0.055	2.984GluLys: 2.984 ± 0.06	5.55GluLeu: 5.55 ± 0.072	1.76GluMet: 1.76 ± 0.042	2.089GluAsn: 2.089 ± 0.045	1.974GluPro: 1.974 ± 0.043	3.161GluGln: 3.161 ± 0.051	3.646GluArg: 3.646 ± 0.061	2.815GluSer: 2.815 ± 0.051	2.751GluThr: 2.751 ± 0.05	3.718GluVal: 3.718 ± 0.052	0.772GluTrp: 0.772 ± 0.028	1.37GluTyr: 1.37 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.093PheAla: 4.093 ± 0.058	0.57PheCys: 0.57 ± 0.022	2.431PheAsp: 2.431 ± 0.053	1.649PheGlu: 1.649 ± 0.041	1.911PhePhe: 1.911 ± 0.05	3.236PheGly: 3.236 ± 0.061	1.011PheHis: 1.011 ± 0.036	2.687PheIle: 2.687 ± 0.051	1.299PheLys: 1.299 ± 0.032	3.423PheLeu: 3.423 ± 0.064	0.994PheMet: 0.994 ± 0.031	1.698PheAsn: 1.698 ± 0.038	1.551PhePro: 1.551 ± 0.038	1.32PheGln: 1.32 ± 0.039	2.266PheArg: 2.266 ± 0.046	3.109PheSer: 3.109 ± 0.051	2.56PheThr: 2.56 ± 0.043	2.665PheVal: 2.665 ± 0.056	0.638PheTrp: 0.638 ± 0.022	1.224PheTyr: 1.224 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	6.563GlyAla: 6.563 ± 0.085	0.986GlyCys: 0.986 ± 0.025	4.076GlyAsp: 4.076 ± 0.069	4.622GlyGlu: 4.622 ± 0.076	3.552GlyPhe: 3.552 ± 0.06	5.788GlyGly: 5.788 ± 0.072	1.843GlyHis: 1.843 ± 0.04	4.916GlyIle: 4.916 ± 0.07	3.72GlyLys: 3.72 ± 0.061	7.612GlyLeu: 7.612 ± 0.088	2.417GlyMet: 2.417 ± 0.049	2.593GlyAsn: 2.593 ± 0.049	2.067GlyPro: 2.067 ± 0.043	3.102GlyGln: 3.102 ± 0.052	4.087GlyArg: 4.087 ± 0.061	3.926GlySer: 3.926 ± 0.058	3.43GlyThr: 3.43 ± 0.049	6.079GlyVal: 6.079 ± 0.076	1.274GlyTrp: 1.274 ± 0.033	2.551GlyTyr: 2.551 ± 0.058	0.0GlyXaa: 0.0 ± 0.0
His	2.244HisAla: 2.244 ± 0.046	0.324HisCys: 0.324 ± 0.015	1.268HisAsp: 1.268 ± 0.028	1.038HisGlu: 1.038 ± 0.027	1.282HisPhe: 1.282 ± 0.035	1.891HisGly: 1.891 ± 0.039	1.141HisHis: 1.141 ± 0.041	1.463HisIle: 1.463 ± 0.034	0.781HisLys: 0.781 ± 0.025	2.517HisLeu: 2.517 ± 0.05	0.552HisMet: 0.552 ± 0.02	0.782HisAsn: 0.782 ± 0.022	1.528HisPro: 1.528 ± 0.036	1.537HisGln: 1.537 ± 0.04	1.863HisArg: 1.863 ± 0.05	1.301HisSer: 1.301 ± 0.031	1.094HisThr: 1.094 ± 0.034	1.487HisVal: 1.487 ± 0.035	0.395HisTrp: 0.395 ± 0.019	0.892HisTyr: 0.892 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.739IleAla: 6.739 ± 0.089	0.671IleCys: 0.671 ± 0.022	3.524IleAsp: 3.524 ± 0.06	3.068IleGlu: 3.068 ± 0.055	2.167IlePhe: 2.167 ± 0.043	4.649IleGly: 4.649 ± 0.068	1.306IleHis: 1.306 ± 0.036	3.177IleIle: 3.177 ± 0.062	2.301IleLys: 2.301 ± 0.046	4.966IleLeu: 4.966 ± 0.071	1.252IleMet: 1.252 ± 0.033	2.408IleAsn: 2.408 ± 0.049	2.703IlePro: 2.703 ± 0.046	1.824IleGln: 1.824 ± 0.039	3.007IleArg: 3.007 ± 0.05	3.514IleSer: 3.514 ± 0.06	3.172IleThr: 3.172 ± 0.048	4.001IleVal: 4.001 ± 0.066	0.675IleTrp: 0.675 ± 0.023	1.415IleTyr: 1.415 ± 0.038	0.0IleXaa: 0.0 ± 0.0
Lys	4.212LysAla: 4.212 ± 0.074	0.289LysCys: 0.289 ± 0.017	1.842LysAsp: 1.842 ± 0.047	2.237LysGlu: 2.237 ± 0.05	1.072LysPhe: 1.072 ± 0.029	2.791LysGly: 2.791 ± 0.053	0.867LysHis: 0.867 ± 0.025	2.28LysIle: 2.28 ± 0.056	2.2LysLys: 2.2 ± 0.052	4.0LysLeu: 4.0 ± 0.064	1.295LysMet: 1.295 ± 0.034	1.583LysAsn: 1.583 ± 0.041	1.94LysPro: 1.94 ± 0.045	1.887LysGln: 1.887 ± 0.042	2.533LysArg: 2.533 ± 0.05	2.119LysSer: 2.119 ± 0.043	2.356LysThr: 2.356 ± 0.05	2.852LysVal: 2.852 ± 0.049	0.414LysTrp: 0.414 ± 0.02	1.074LysTyr: 1.074 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	11.887LeuAla: 11.887 ± 0.115	1.318LeuCys: 1.318 ± 0.037	5.133LeuAsp: 5.133 ± 0.07	5.162LeuGlu: 5.162 ± 0.074	4.479LeuPhe: 4.479 ± 0.073	7.268LeuGly: 7.268 ± 0.095	2.493LeuHis: 2.493 ± 0.047	5.755LeuIle: 5.755 ± 0.073	4.174LeuLys: 4.174 ± 0.065	12.208LeuLeu: 12.208 ± 0.143	2.904LeuMet: 2.904 ± 0.052	3.956LeuAsn: 3.956 ± 0.057	5.622LeuPro: 5.622 ± 0.065	4.578LeuGln: 4.578 ± 0.069	6.81LeuArg: 6.81 ± 0.079	6.919LeuSer: 6.919 ± 0.092	6.161LeuThr: 6.161 ± 0.073	7.019LeuVal: 7.019 ± 0.086	1.436LeuTrp: 1.436 ± 0.037	2.437LeuTyr: 2.437 ± 0.047	0.0LeuXaa: 0.0 ± 0.0
Met	3.077MetAla: 3.077 ± 0.051	0.209MetCys: 0.209 ± 0.013	1.096MetAsp: 1.096 ± 0.029	1.212MetGlu: 1.212 ± 0.032	0.91MetPhe: 0.91 ± 0.027	1.864MetGly: 1.864 ± 0.037	0.577MetHis: 0.577 ± 0.019	1.446MetIle: 1.446 ± 0.041	1.337MetLys: 1.337 ± 0.032	3.207MetLeu: 3.207 ± 0.056	0.883MetMet: 0.883 ± 0.028	1.097MetAsn: 1.097 ± 0.034	1.412MetPro: 1.412 ± 0.033	1.231MetGln: 1.231 ± 0.03	1.561MetArg: 1.561 ± 0.031	1.799MetSer: 1.799 ± 0.04	1.784MetThr: 1.784 ± 0.036	2.019MetVal: 2.019 ± 0.041	0.269MetTrp: 0.269 ± 0.013	0.51MetTyr: 0.51 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.213AsnAla: 3.213 ± 0.05	0.322AsnCys: 0.322 ± 0.016	1.966AsnAsp: 1.966 ± 0.041	1.781AsnGlu: 1.781 ± 0.037	1.275AsnPhe: 1.275 ± 0.034	2.842AsnGly: 2.842 ± 0.049	0.917AsnHis: 0.917 ± 0.028	2.174AsnIle: 2.174 ± 0.046	1.457AsnLys: 1.457 ± 0.041	3.219AsnLeu: 3.219 ± 0.05	0.91AsnMet: 0.91 ± 0.029	1.449AsnAsn: 1.449 ± 0.044	1.958AsnPro: 1.958 ± 0.04	1.486AsnGln: 1.486 ± 0.04	2.016AsnArg: 2.016 ± 0.039	1.869AsnSer: 1.869 ± 0.039	1.799AsnThr: 1.799 ± 0.046	2.459AsnVal: 2.459 ± 0.051	0.485AsnTrp: 0.485 ± 0.018	1.028AsnTyr: 1.028 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	4.983ProAla: 4.983 ± 0.065	0.41ProCys: 0.41 ± 0.016	2.631ProAsp: 2.631 ± 0.047	3.114ProGlu: 3.114 ± 0.054	1.916ProPhe: 1.916 ± 0.041	3.697ProGly: 3.697 ± 0.06	1.15ProHis: 1.15 ± 0.029	1.719ProIle: 1.719 ± 0.041	1.33ProLys: 1.33 ± 0.031	5.2ProLeu: 5.2 ± 0.067	1.09ProMet: 1.09 ± 0.031	1.159ProAsn: 1.159 ± 0.031	1.791ProPro: 1.791 ± 0.053	2.44ProGln: 2.44 ± 0.046	2.31ProArg: 2.31 ± 0.047	2.106ProSer: 2.106 ± 0.042	2.001ProThr: 2.001 ± 0.039	3.826ProVal: 3.826 ± 0.055	0.781ProTrp: 0.781 ± 0.028	1.104ProTyr: 1.104 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	4.952GlnAla: 4.952 ± 0.067	0.405GlnCys: 0.405 ± 0.02	1.693GlnAsp: 1.693 ± 0.04	2.032GlnGlu: 2.032 ± 0.042	1.567GlnPhe: 1.567 ± 0.036	3.22GlnGly: 3.22 ± 0.05	1.539GlnHis: 1.539 ± 0.04	2.331GlnIle: 2.331 ± 0.042	1.682GlnLys: 1.682 ± 0.044	5.204GlnLeu: 5.204 ± 0.073	1.248GlnMet: 1.248 ± 0.036	1.321GlnAsn: 1.321 ± 0.035	2.392GlnPro: 2.392 ± 0.047	3.49GlnGln: 3.49 ± 0.073	4.151GlnArg: 4.151 ± 0.073	2.132GlnSer: 2.132 ± 0.047	2.216GlnThr: 2.216 ± 0.044	3.113GlnVal: 3.113 ± 0.054	0.608GlnTrp: 0.608 ± 0.022	1.125GlnTyr: 1.125 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	5.264ArgAla: 5.264 ± 0.074	0.678ArgCys: 0.678 ± 0.026	3.214ArgAsp: 3.214 ± 0.057	3.876ArgGlu: 3.876 ± 0.064	2.953ArgPhe: 2.953 ± 0.058	3.829ArgGly: 3.829 ± 0.056	2.101ArgHis: 2.101 ± 0.049	3.509ArgIle: 3.509 ± 0.058	2.385ArgLys: 2.385 ± 0.042	7.174ArgLeu: 7.174 ± 0.097	1.732ArgMet: 1.732 ± 0.037	1.922ArgAsn: 1.922 ± 0.047	2.658ArgPro: 2.658 ± 0.051	3.984ArgGln: 3.984 ± 0.073	4.868ArgArg: 4.868 ± 0.094	2.883ArgSer: 2.883 ± 0.051	2.571ArgThr: 2.571 ± 0.05	4.111ArgVal: 4.111 ± 0.064	1.025ArgTrp: 1.025 ± 0.029	2.147ArgTyr: 2.147 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	5.604SerAla: 5.604 ± 0.072	0.61SerCys: 0.61 ± 0.021	2.999SerAsp: 2.999 ± 0.05	2.981SerGlu: 2.981 ± 0.048	2.235SerPhe: 2.235 ± 0.045	5.002SerGly: 5.002 ± 0.07	1.404SerHis: 1.404 ± 0.032	2.89SerIle: 2.89 ± 0.053	1.945SerLys: 1.945 ± 0.042	6.348SerLeu: 6.348 ± 0.08	1.492SerMet: 1.492 ± 0.039	1.751SerAsn: 1.751 ± 0.04	2.673SerPro: 2.673 ± 0.05	2.435SerGln: 2.435 ± 0.045	3.543SerArg: 3.543 ± 0.051	3.397SerSer: 3.397 ± 0.071	2.715SerThr: 2.715 ± 0.051	4.006SerVal: 4.006 ± 0.063	0.954SerTrp: 0.954 ± 0.028	1.518SerTyr: 1.518 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	4.989ThrAla: 4.989 ± 0.079	0.52ThrCys: 0.52 ± 0.02	2.456ThrAsp: 2.456 ± 0.043	2.452ThrGlu: 2.452 ± 0.048	2.048ThrPhe: 2.048 ± 0.046	4.248ThrGly: 4.248 ± 0.054	1.228ThrHis: 1.228 ± 0.031	2.721ThrIle: 2.721 ± 0.048	1.434ThrLys: 1.434 ± 0.036	6.991ThrLeu: 6.991 ± 0.085	1.111ThrMet: 1.111 ± 0.033	1.376ThrAsn: 1.376 ± 0.035	2.937ThrPro: 2.937 ± 0.043	1.89ThrGln: 1.89 ± 0.041	3.138ThrArg: 3.138 ± 0.057	2.786ThrSer: 2.786 ± 0.054	2.784ThrThr: 2.784 ± 0.059	3.833ThrVal: 3.833 ± 0.054	0.814ThrTrp: 0.814 ± 0.026	1.138ThrTyr: 1.138 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.604ValAla: 7.604 ± 0.088	0.81ValCys: 0.81 ± 0.028	3.854ValAsp: 3.854 ± 0.055	3.954ValGlu: 3.954 ± 0.06	2.797ValPhe: 2.797 ± 0.053	5.138ValGly: 5.138 ± 0.074	1.358ValHis: 1.358 ± 0.037	4.429ValIle: 4.429 ± 0.064	3.01ValLys: 3.01 ± 0.052	7.089ValLeu: 7.089 ± 0.085	2.142ValMet: 2.142 ± 0.038	2.661ValAsn: 2.661 ± 0.048	2.945ValPro: 2.945 ± 0.047	2.532ValGln: 2.532 ± 0.045	3.991ValArg: 3.991 ± 0.064	4.523ValSer: 4.523 ± 0.059	4.051ValThr: 4.051 ± 0.058	5.784ValVal: 5.784 ± 0.086	0.98ValTrp: 0.98 ± 0.027	1.752ValTyr: 1.752 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	0.975TrpAla: 0.975 ± 0.029	0.183TrpCys: 0.183 ± 0.012	0.593TrpAsp: 0.593 ± 0.024	0.561TrpGlu: 0.561 ± 0.02	0.709TrpPhe: 0.709 ± 0.027	0.847TrpGly: 0.847 ± 0.028	0.463TrpHis: 0.463 ± 0.02	0.714TrpIle: 0.714 ± 0.025	0.503TrpLys: 0.503 ± 0.023	2.336TrpLeu: 2.336 ± 0.05	0.44TrpMet: 0.44 ± 0.02	0.483TrpAsn: 0.483 ± 0.023	0.654TrpPro: 0.654 ± 0.024	1.087TrpGln: 1.087 ± 0.031	1.203TrpArg: 1.203 ± 0.035	0.831TrpSer: 0.831 ± 0.024	0.605TrpThr: 0.605 ± 0.025	0.924TrpVal: 0.924 ± 0.027	0.231TrpTrp: 0.231 ± 0.015	0.407TrpTyr: 0.407 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.366TyrAla: 2.366 ± 0.05	0.367TyrCys: 0.367 ± 0.017	1.476TyrAsp: 1.476 ± 0.04	1.163TyrGlu: 1.163 ± 0.032	1.147TyrPhe: 1.147 ± 0.033	2.071TyrGly: 2.071 ± 0.044	0.73TyrHis: 0.73 ± 0.023	1.348TyrIle: 1.348 ± 0.03	0.873TyrLys: 0.873 ± 0.028	2.891TyrLeu: 2.891 ± 0.049	0.592TyrMet: 0.592 ± 0.02	0.898TyrAsn: 0.898 ± 0.03	1.323TyrPro: 1.323 ± 0.035	1.488TyrGln: 1.488 ± 0.036	1.924TyrArg: 1.924 ± 0.04	1.613TyrSer: 1.613 ± 0.036	1.373TyrThr: 1.373 ± 0.038	1.617TyrVal: 1.617 ± 0.037	0.405TyrTrp: 0.405 ± 0.019	0.867TyrTyr: 0.867 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5434 proteins (1237787 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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