Amino acid dipepetide frequency for Mycobacterium phage CaptainTrips

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.455AlaAla: 15.455 ± 1.885
0.976AlaCys: 0.976 ± 0.23
7.429AlaAsp: 7.429 ± 0.688
7.754AlaGlu: 7.754 ± 0.796
2.766AlaPhe: 2.766 ± 0.404
9.707AlaGly: 9.707 ± 1.158
2.278AlaHis: 2.278 ± 0.337
4.175AlaIle: 4.175 ± 0.543
3.85AlaLys: 3.85 ± 0.429
8.026AlaLeu: 8.026 ± 0.753
2.386AlaMet: 2.386 ± 0.397
2.44AlaAsn: 2.44 ± 0.362
5.043AlaPro: 5.043 ± 0.502
3.796AlaGln: 3.796 ± 0.487
8.243AlaArg: 8.243 ± 0.833
5.206AlaSer: 5.206 ± 0.686
6.453AlaThr: 6.453 ± 0.593
7.592AlaVal: 7.592 ± 0.668
2.603AlaTrp: 2.603 ± 0.444
2.115AlaTyr: 2.115 ± 0.324
0.0AlaXaa: 0.0 ± 0.0
Cys
1.301CysAla: 1.301 ± 0.332
0.108CysCys: 0.108 ± 0.082
1.139CysAsp: 1.139 ± 0.299
0.976CysGlu: 0.976 ± 0.239
0.271CysPhe: 0.271 ± 0.128
1.464CysGly: 1.464 ± 0.292
0.38CysHis: 0.38 ± 0.144
0.108CysIle: 0.108 ± 0.082
0.434CysLys: 0.434 ± 0.165
0.813CysLeu: 0.813 ± 0.252
0.325CysMet: 0.325 ± 0.134
0.434CysAsn: 0.434 ± 0.142
1.085CysPro: 1.085 ± 0.296
0.325CysGln: 0.325 ± 0.125
0.813CysArg: 0.813 ± 0.219
0.759CysSer: 0.759 ± 0.2
0.868CysThr: 0.868 ± 0.289
0.596CysVal: 0.596 ± 0.161
0.217CysTrp: 0.217 ± 0.109
0.38CysTyr: 0.38 ± 0.148
0.0CysXaa: 0.0 ± 0.0
Asp
7.104AspAla: 7.104 ± 0.657
0.922AspCys: 0.922 ± 0.267
4.609AspAsp: 4.609 ± 0.522
2.982AspGlu: 2.982 ± 0.377
1.844AspPhe: 1.844 ± 0.309
6.887AspGly: 6.887 ± 0.644
1.193AspHis: 1.193 ± 0.255
2.332AspIle: 2.332 ± 0.319
1.627AspLys: 1.627 ± 0.291
5.911AspLeu: 5.911 ± 0.557
1.085AspMet: 1.085 ± 0.276
1.789AspAsn: 1.789 ± 0.344
5.043AspPro: 5.043 ± 0.575
2.006AspGln: 2.006 ± 0.303
5.043AspArg: 5.043 ± 0.539
3.85AspSer: 3.85 ± 0.581
4.175AspThr: 4.175 ± 0.532
4.121AspVal: 4.121 ± 0.518
1.627AspTrp: 1.627 ± 0.339
1.952AspTyr: 1.952 ± 0.365
0.0AspXaa: 0.0 ± 0.0
Glu
6.019GluAla: 6.019 ± 0.613
1.03GluCys: 1.03 ± 0.313
2.657GluAsp: 2.657 ± 0.361
2.766GluGlu: 2.766 ± 0.53
2.223GluPhe: 2.223 ± 0.315
2.982GluGly: 2.982 ± 0.438
1.735GluHis: 1.735 ± 0.384
2.115GluIle: 2.115 ± 0.307
2.006GluLys: 2.006 ± 0.311
5.64GluLeu: 5.64 ± 0.709
1.573GluMet: 1.573 ± 0.306
1.681GluAsn: 1.681 ± 0.236
2.44GluPro: 2.44 ± 0.398
3.199GluGln: 3.199 ± 0.458
5.368GluArg: 5.368 ± 0.615
3.471GluSer: 3.471 ± 0.557
3.959GluThr: 3.959 ± 0.617
4.284GluVal: 4.284 ± 0.475
1.681GluTrp: 1.681 ± 0.311
1.898GluTyr: 1.898 ± 0.301
0.0GluXaa: 0.0 ± 0.0
Phe
3.199PheAla: 3.199 ± 0.408
0.271PheCys: 0.271 ± 0.127
2.44PheAsp: 2.44 ± 0.417
1.681PheGlu: 1.681 ± 0.285
0.922PhePhe: 0.922 ± 0.282
2.874PheGly: 2.874 ± 0.592
0.38PheHis: 0.38 ± 0.146
1.41PheIle: 1.41 ± 0.316
0.813PheLys: 0.813 ± 0.193
1.518PheLeu: 1.518 ± 0.241
0.813PheMet: 0.813 ± 0.265
1.356PheAsn: 1.356 ± 0.318
1.464PhePro: 1.464 ± 0.321
1.03PheGln: 1.03 ± 0.278
2.006PheArg: 2.006 ± 0.322
1.301PheSer: 1.301 ± 0.255
2.169PheThr: 2.169 ± 0.405
2.386PheVal: 2.386 ± 0.344
0.542PheTrp: 0.542 ± 0.15
0.922PheTyr: 0.922 ± 0.273
0.0PheXaa: 0.0 ± 0.0
Gly
8.785GlyAla: 8.785 ± 1.116
1.085GlyCys: 1.085 ± 0.307
5.965GlyAsp: 5.965 ± 0.637
4.284GlyGlu: 4.284 ± 0.599
2.874GlyPhe: 2.874 ± 0.408
8.243GlyGly: 8.243 ± 1.22
2.006GlyHis: 2.006 ± 0.285
4.175GlyIle: 4.175 ± 0.58
2.44GlyLys: 2.44 ± 0.385
6.29GlyLeu: 6.29 ± 0.592
2.386GlyMet: 2.386 ± 0.425
3.091GlyAsn: 3.091 ± 0.428
4.555GlyPro: 4.555 ± 0.45
2.44GlyGln: 2.44 ± 0.531
5.477GlyArg: 5.477 ± 0.662
5.152GlySer: 5.152 ± 0.699
6.128GlyThr: 6.128 ± 0.709
5.531GlyVal: 5.531 ± 0.571
2.386GlyTrp: 2.386 ± 0.349
1.518GlyTyr: 1.518 ± 0.286
0.0GlyXaa: 0.0 ± 0.0
His
2.061HisAla: 2.061 ± 0.364
0.542HisCys: 0.542 ± 0.199
1.193HisAsp: 1.193 ± 0.254
1.085HisGlu: 1.085 ± 0.258
0.434HisPhe: 0.434 ± 0.149
1.844HisGly: 1.844 ± 0.289
0.813HisHis: 0.813 ± 0.221
1.356HisIle: 1.356 ± 0.292
0.868HisLys: 0.868 ± 0.254
1.356HisLeu: 1.356 ± 0.271
0.542HisMet: 0.542 ± 0.156
0.868HisAsn: 0.868 ± 0.184
1.789HisPro: 1.789 ± 0.318
0.759HisGln: 0.759 ± 0.171
2.115HisArg: 2.115 ± 0.328
0.759HisSer: 0.759 ± 0.219
1.41HisThr: 1.41 ± 0.36
1.41HisVal: 1.41 ± 0.291
0.488HisTrp: 0.488 ± 0.157
0.922HisTyr: 0.922 ± 0.23
0.0HisXaa: 0.0 ± 0.0
Ile
5.314IleAla: 5.314 ± 0.464
0.596IleCys: 0.596 ± 0.262
3.85IleAsp: 3.85 ± 0.498
3.471IleGlu: 3.471 ± 0.34
0.813IlePhe: 0.813 ± 0.258
3.579IleGly: 3.579 ± 0.503
1.464IleHis: 1.464 ± 0.269
1.681IleIle: 1.681 ± 0.304
1.139IleLys: 1.139 ± 0.253
2.115IleLeu: 2.115 ± 0.452
0.434IleMet: 0.434 ± 0.164
1.898IleAsn: 1.898 ± 0.287
2.82IlePro: 2.82 ± 0.323
1.301IleGln: 1.301 ± 0.252
2.82IleArg: 2.82 ± 0.442
1.844IleSer: 1.844 ± 0.342
3.416IleThr: 3.416 ± 0.436
2.928IleVal: 2.928 ± 0.403
0.922IleTrp: 0.922 ± 0.226
0.542IleTyr: 0.542 ± 0.215
0.0IleXaa: 0.0 ± 0.0
Lys
3.85LysAla: 3.85 ± 0.457
0.542LysCys: 0.542 ± 0.152
1.844LysAsp: 1.844 ± 0.33
1.518LysGlu: 1.518 ± 0.274
1.247LysPhe: 1.247 ± 0.241
2.278LysGly: 2.278 ± 0.334
1.03LysHis: 1.03 ± 0.239
1.085LysIle: 1.085 ± 0.238
1.247LysLys: 1.247 ± 0.32
2.874LysLeu: 2.874 ± 0.45
0.868LysMet: 0.868 ± 0.193
0.976LysAsn: 0.976 ± 0.251
2.494LysPro: 2.494 ± 0.451
1.681LysGln: 1.681 ± 0.284
2.061LysArg: 2.061 ± 0.377
1.844LysSer: 1.844 ± 0.264
2.061LysThr: 2.061 ± 0.321
2.332LysVal: 2.332 ± 0.363
0.651LysTrp: 0.651 ± 0.157
0.922LysTyr: 0.922 ± 0.281
0.0LysXaa: 0.0 ± 0.0
Leu
8.188LeuAla: 8.188 ± 0.79
0.759LeuCys: 0.759 ± 0.229
4.718LeuAsp: 4.718 ± 0.57
3.959LeuGlu: 3.959 ± 0.489
2.332LeuPhe: 2.332 ± 0.313
5.477LeuGly: 5.477 ± 0.613
1.247LeuHis: 1.247 ± 0.283
3.525LeuIle: 3.525 ± 0.434
2.494LeuLys: 2.494 ± 0.4
4.826LeuLeu: 4.826 ± 0.482
1.41LeuMet: 1.41 ± 0.265
2.657LeuAsn: 2.657 ± 0.381
5.26LeuPro: 5.26 ± 0.585
2.44LeuGln: 2.44 ± 0.325
5.043LeuArg: 5.043 ± 0.67
5.694LeuSer: 5.694 ± 0.525
5.314LeuThr: 5.314 ± 0.496
5.206LeuVal: 5.206 ± 0.553
1.464LeuTrp: 1.464 ± 0.248
2.006LeuTyr: 2.006 ± 0.366
0.0LeuXaa: 0.0 ± 0.0
Met
2.332MetAla: 2.332 ± 0.331
0.108MetCys: 0.108 ± 0.076
1.247MetAsp: 1.247 ± 0.28
1.03MetGlu: 1.03 ± 0.211
0.868MetPhe: 0.868 ± 0.24
1.681MetGly: 1.681 ± 0.263
0.271MetHis: 0.271 ± 0.137
0.813MetIle: 0.813 ± 0.213
0.759MetLys: 0.759 ± 0.229
2.169MetLeu: 2.169 ± 0.29
0.596MetMet: 0.596 ± 0.219
0.976MetAsn: 0.976 ± 0.261
1.247MetPro: 1.247 ± 0.252
0.488MetGln: 0.488 ± 0.122
1.627MetArg: 1.627 ± 0.267
2.928MetSer: 2.928 ± 0.408
2.386MetThr: 2.386 ± 0.343
1.301MetVal: 1.301 ± 0.317
0.325MetTrp: 0.325 ± 0.112
0.38MetTyr: 0.38 ± 0.132
0.0MetXaa: 0.0 ± 0.0
Asn
3.199AsnAla: 3.199 ± 0.31
0.163AsnCys: 0.163 ± 0.083
2.006AsnAsp: 2.006 ± 0.343
1.627AsnGlu: 1.627 ± 0.367
0.922AsnPhe: 0.922 ± 0.288
3.796AsnGly: 3.796 ± 0.469
0.922AsnHis: 0.922 ± 0.213
1.356AsnIle: 1.356 ± 0.378
1.139AsnLys: 1.139 ± 0.286
2.223AsnLeu: 2.223 ± 0.375
0.651AsnMet: 0.651 ± 0.18
1.627AsnAsn: 1.627 ± 0.375
2.44AsnPro: 2.44 ± 0.338
1.139AsnGln: 1.139 ± 0.296
2.332AsnArg: 2.332 ± 0.354
1.464AsnSer: 1.464 ± 0.257
2.169AsnThr: 2.169 ± 0.302
2.006AsnVal: 2.006 ± 0.333
0.813AsnTrp: 0.813 ± 0.165
0.868AsnTyr: 0.868 ± 0.212
0.0AsnXaa: 0.0 ± 0.0
Pro
5.477ProAla: 5.477 ± 0.64
0.488ProCys: 0.488 ± 0.168
4.447ProAsp: 4.447 ± 0.522
4.392ProGlu: 4.392 ± 0.504
1.573ProPhe: 1.573 ± 0.306
7.05ProGly: 7.05 ± 0.657
1.464ProHis: 1.464 ± 0.292
2.278ProIle: 2.278 ± 0.286
2.169ProLys: 2.169 ± 0.425
4.447ProLeu: 4.447 ± 0.54
1.627ProMet: 1.627 ± 0.345
2.223ProAsn: 2.223 ± 0.339
4.23ProPro: 4.23 ± 0.596
2.169ProGln: 2.169 ± 0.298
3.254ProArg: 3.254 ± 0.478
2.874ProSer: 2.874 ± 0.422
3.199ProThr: 3.199 ± 0.467
4.935ProVal: 4.935 ± 0.648
1.085ProTrp: 1.085 ± 0.222
1.681ProTyr: 1.681 ± 0.292
0.0ProXaa: 0.0 ± 0.0
Gln
4.664GlnAla: 4.664 ± 0.584
0.434GlnCys: 0.434 ± 0.238
1.41GlnAsp: 1.41 ± 0.263
1.573GlnGlu: 1.573 ± 0.307
1.085GlnPhe: 1.085 ± 0.219
2.223GlnGly: 2.223 ± 0.442
0.868GlnHis: 0.868 ± 0.233
1.681GlnIle: 1.681 ± 0.23
1.193GlnLys: 1.193 ± 0.214
3.308GlnLeu: 3.308 ± 0.382
0.705GlnMet: 0.705 ± 0.197
1.085GlnAsn: 1.085 ± 0.243
2.657GlnPro: 2.657 ± 0.396
1.193GlnGln: 1.193 ± 0.3
2.332GlnArg: 2.332 ± 0.37
2.115GlnSer: 2.115 ± 0.356
1.735GlnThr: 1.735 ± 0.328
2.494GlnVal: 2.494 ± 0.308
0.705GlnTrp: 0.705 ± 0.185
0.922GlnTyr: 0.922 ± 0.266
0.0GlnXaa: 0.0 ± 0.0
Arg
6.399ArgAla: 6.399 ± 0.763
1.301ArgCys: 1.301 ± 0.298
4.23ArgAsp: 4.23 ± 0.666
5.097ArgGlu: 5.097 ± 0.676
2.061ArgPhe: 2.061 ± 0.362
4.284ArgGly: 4.284 ± 0.487
1.518ArgHis: 1.518 ± 0.331
3.579ArgIle: 3.579 ± 0.583
2.332ArgLys: 2.332 ± 0.365
5.097ArgLeu: 5.097 ± 0.683
2.711ArgMet: 2.711 ± 0.387
2.061ArgAsn: 2.061 ± 0.396
3.687ArgPro: 3.687 ± 0.399
1.844ArgGln: 1.844 ± 0.322
5.64ArgArg: 5.64 ± 0.831
3.85ArgSer: 3.85 ± 0.504
3.959ArgThr: 3.959 ± 0.473
5.531ArgVal: 5.531 ± 0.588
2.061ArgTrp: 2.061 ± 0.364
2.115ArgTyr: 2.115 ± 0.34
0.0ArgXaa: 0.0 ± 0.0
Ser
6.019SerAla: 6.019 ± 1.164
0.976SerCys: 0.976 ± 0.322
4.284SerAsp: 4.284 ± 0.502
3.416SerGlu: 3.416 ± 0.475
1.952SerPhe: 1.952 ± 0.458
5.911SerGly: 5.911 ± 0.697
1.139SerHis: 1.139 ± 0.225
2.928SerIle: 2.928 ± 0.457
2.278SerLys: 2.278 ± 0.434
3.742SerLeu: 3.742 ± 0.476
1.573SerMet: 1.573 ± 0.266
2.061SerAsn: 2.061 ± 0.344
3.471SerPro: 3.471 ± 0.443
1.681SerGln: 1.681 ± 0.285
2.82SerArg: 2.82 ± 0.396
3.471SerSer: 3.471 ± 0.523
2.982SerThr: 2.982 ± 0.372
4.609SerVal: 4.609 ± 0.51
1.356SerTrp: 1.356 ± 0.235
1.356SerTyr: 1.356 ± 0.197
0.0SerXaa: 0.0 ± 0.0
Thr
6.453ThrAla: 6.453 ± 0.698
0.813ThrCys: 0.813 ± 0.225
4.338ThrAsp: 4.338 ± 0.566
3.416ThrGlu: 3.416 ± 0.445
1.789ThrPhe: 1.789 ± 0.331
6.128ThrGly: 6.128 ± 0.604
1.735ThrHis: 1.735 ± 0.334
3.037ThrIle: 3.037 ± 0.42
2.332ThrLys: 2.332 ± 0.4
4.609ThrLeu: 4.609 ± 0.492
1.356ThrMet: 1.356 ± 0.266
2.386ThrAsn: 2.386 ± 0.341
4.447ThrPro: 4.447 ± 0.505
2.115ThrGln: 2.115 ± 0.325
4.013ThrArg: 4.013 ± 0.449
3.959ThrSer: 3.959 ± 0.44
4.772ThrThr: 4.772 ± 0.625
5.748ThrVal: 5.748 ± 0.639
1.085ThrTrp: 1.085 ± 0.298
1.952ThrTyr: 1.952 ± 0.323
0.0ThrXaa: 0.0 ± 0.0
Val
7.429ValAla: 7.429 ± 0.508
1.247ValCys: 1.247 ± 0.24
5.26ValAsp: 5.26 ± 0.506
4.935ValGlu: 4.935 ± 0.653
2.169ValPhe: 2.169 ± 0.351
5.206ValGly: 5.206 ± 0.751
1.41ValHis: 1.41 ± 0.308
2.928ValIle: 2.928 ± 0.416
2.44ValLys: 2.44 ± 0.329
5.152ValLeu: 5.152 ± 0.544
1.464ValMet: 1.464 ± 0.237
2.006ValAsn: 2.006 ± 0.309
4.23ValPro: 4.23 ± 0.45
2.982ValGln: 2.982 ± 0.369
4.447ValArg: 4.447 ± 0.497
5.043ValSer: 5.043 ± 0.549
5.64ValThr: 5.64 ± 0.564
6.236ValVal: 6.236 ± 0.726
1.789ValTrp: 1.789 ± 0.328
1.139ValTyr: 1.139 ± 0.241
0.0ValXaa: 0.0 ± 0.0
Trp
2.711TrpAla: 2.711 ± 0.362
0.163TrpCys: 0.163 ± 0.093
1.356TrpAsp: 1.356 ± 0.283
1.085TrpGlu: 1.085 ± 0.322
0.651TrpPhe: 0.651 ± 0.168
1.03TrpGly: 1.03 ± 0.254
0.434TrpHis: 0.434 ± 0.156
1.03TrpIle: 1.03 ± 0.166
1.085TrpLys: 1.085 ± 0.208
1.898TrpLeu: 1.898 ± 0.349
0.705TrpMet: 0.705 ± 0.205
0.596TrpAsn: 0.596 ± 0.199
1.03TrpPro: 1.03 ± 0.272
0.922TrpGln: 0.922 ± 0.307
2.115TrpArg: 2.115 ± 0.438
1.518TrpSer: 1.518 ± 0.372
1.898TrpThr: 1.898 ± 0.347
1.681TrpVal: 1.681 ± 0.419
1.03TrpTrp: 1.03 ± 0.185
0.38TrpTyr: 0.38 ± 0.14
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.332TyrAla: 2.332 ± 0.355
0.271TyrCys: 0.271 ± 0.109
1.681TyrAsp: 1.681 ± 0.312
1.681TyrGlu: 1.681 ± 0.29
0.705TyrPhe: 0.705 ± 0.188
2.169TyrGly: 2.169 ± 0.385
0.325TyrHis: 0.325 ± 0.116
1.356TyrIle: 1.356 ± 0.248
0.759TyrLys: 0.759 ± 0.221
2.006TyrLeu: 2.006 ± 0.314
0.271TyrMet: 0.271 ± 0.115
0.651TyrAsn: 0.651 ± 0.165
1.627TyrPro: 1.627 ± 0.231
0.868TyrGln: 0.868 ± 0.206
1.789TyrArg: 1.789 ± 0.332
0.976TyrSer: 0.976 ± 0.206
1.789TyrThr: 1.789 ± 0.387
2.223TyrVal: 2.223 ± 0.332
0.488TyrTrp: 0.488 ± 0.13
0.651TyrTyr: 0.651 ± 0.153
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 107 proteins (18442 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski