Amino acid dipepetide frequency for Pelomicrobium methylotrophicum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.891AlaAla: 15.891 ± 0.203	1.418AlaCys: 1.418 ± 0.046	5.294AlaAsp: 5.294 ± 0.082	7.498AlaGlu: 7.498 ± 0.099	4.141AlaPhe: 4.141 ± 0.08	9.821AlaGly: 9.821 ± 0.105	2.517AlaHis: 2.517 ± 0.053	5.358AlaIle: 5.358 ± 0.086	3.804AlaLys: 3.804 ± 0.091	14.424AlaLeu: 14.424 ± 0.161	2.989AlaMet: 2.989 ± 0.063	2.384AlaAsn: 2.384 ± 0.058	5.344AlaPro: 5.344 ± 0.1	4.475AlaGln: 4.475 ± 0.071	10.309AlaArg: 10.309 ± 0.133	5.577AlaSer: 5.577 ± 0.074	5.061AlaThr: 5.061 ± 0.083	9.381AlaVal: 9.381 ± 0.112	1.89AlaTrp: 1.89 ± 0.05	2.719AlaTyr: 2.719 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	1.18CysAla: 1.18 ± 0.034	0.147CysCys: 0.147 ± 0.013	0.515CysAsp: 0.515 ± 0.023	0.556CysGlu: 0.556 ± 0.025	0.337CysPhe: 0.337 ± 0.019	1.141CysGly: 1.141 ± 0.04	0.335CysHis: 0.335 ± 0.022	0.388CysIle: 0.388 ± 0.021	0.242CysLys: 0.242 ± 0.017	0.957CysLeu: 0.957 ± 0.032	0.184CysMet: 0.184 ± 0.015	0.248CysAsn: 0.248 ± 0.015	0.715CysPro: 0.715 ± 0.033	0.284CysGln: 0.284 ± 0.02	0.86CysArg: 0.86 ± 0.03	0.484CysSer: 0.484 ± 0.025	0.481CysThr: 0.481 ± 0.025	0.714CysVal: 0.714 ± 0.032	0.12CysTrp: 0.12 ± 0.011	0.254CysTyr: 0.254 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	5.508AspAla: 5.508 ± 0.081	0.45AspCys: 0.45 ± 0.023	2.174AspAsp: 2.174 ± 0.051	3.381AspGlu: 3.381 ± 0.07	2.018AspPhe: 2.018 ± 0.051	4.074AspGly: 4.074 ± 0.068	1.069AspHis: 1.069 ± 0.039	2.233AspIle: 2.233 ± 0.058	1.534AspLys: 1.534 ± 0.043	5.284AspLeu: 5.284 ± 0.075	0.994AspMet: 0.994 ± 0.033	0.97AspAsn: 0.97 ± 0.032	3.477AspPro: 3.477 ± 0.069	1.462AspGln: 1.462 ± 0.041	3.812AspArg: 3.812 ± 0.064	1.749AspSer: 1.749 ± 0.045	2.149AspThr: 2.149 ± 0.044	3.736AspVal: 3.736 ± 0.065	0.843AspTrp: 0.843 ± 0.032	1.495AspTyr: 1.495 ± 0.037	0.0AspXaa: 0.0 ± 0.0
Glu	8.78GluAla: 8.78 ± 0.114	0.516GluCys: 0.516 ± 0.025	2.666GluAsp: 2.666 ± 0.064	4.308GluGlu: 4.308 ± 0.083	1.992GluPhe: 1.992 ± 0.047	4.584GluGly: 4.584 ± 0.07	1.404GluHis: 1.404 ± 0.04	3.488GluIle: 3.488 ± 0.071	2.42GluLys: 2.42 ± 0.057	6.561GluLeu: 6.561 ± 0.09	1.422GluMet: 1.422 ± 0.033	1.558GluAsn: 1.558 ± 0.041	2.919GluPro: 2.919 ± 0.057	2.485GluGln: 2.485 ± 0.053	6.555GluArg: 6.555 ± 0.103	2.557GluSer: 2.557 ± 0.059	3.114GluThr: 3.114 ± 0.06	5.032GluVal: 5.032 ± 0.077	0.871GluTrp: 0.871 ± 0.028	1.4GluTyr: 1.4 ± 0.04	0.0GluXaa: 0.0 ± 0.0
Phe	3.885PheAla: 3.885 ± 0.07	0.403PheCys: 0.403 ± 0.022	2.268PheAsp: 2.268 ± 0.056	2.233PheGlu: 2.233 ± 0.047	1.473PhePhe: 1.473 ± 0.051	3.131PheGly: 3.131 ± 0.061	0.829PheHis: 0.829 ± 0.034	1.508PheIle: 1.508 ± 0.042	1.059PheLys: 1.059 ± 0.04	3.52PheLeu: 3.52 ± 0.068	0.752PheMet: 0.752 ± 0.03	1.026PheAsn: 1.026 ± 0.032	1.784PhePro: 1.784 ± 0.044	1.08PheGln: 1.08 ± 0.033	2.431PheArg: 2.431 ± 0.044	1.977PheSer: 1.977 ± 0.052	1.733PheThr: 1.733 ± 0.041	2.896PheVal: 2.896 ± 0.063	0.541PheTrp: 0.541 ± 0.027	0.995PheTyr: 0.995 ± 0.037	0.0PheXaa: 0.0 ± 0.0
Gly	8.444GlyAla: 8.444 ± 0.135	1.057GlyCys: 1.057 ± 0.035	3.654GlyAsp: 3.654 ± 0.059	5.09GlyGlu: 5.09 ± 0.076	3.298GlyPhe: 3.298 ± 0.066	6.543GlyGly: 6.543 ± 0.098	1.832GlyHis: 1.832 ± 0.049	4.237GlyIle: 4.237 ± 0.066	3.258GlyLys: 3.258 ± 0.064	8.619GlyLeu: 8.619 ± 0.113	2.248GlyMet: 2.248 ± 0.054	1.91GlyAsn: 1.91 ± 0.056	3.244GlyPro: 3.244 ± 0.062	2.67GlyGln: 2.67 ± 0.054	6.763GlyArg: 6.763 ± 0.086	3.906GlySer: 3.906 ± 0.065	4.12GlyThr: 4.12 ± 0.069	6.689GlyVal: 6.689 ± 0.09	1.305GlyTrp: 1.305 ± 0.038	2.405GlyTyr: 2.405 ± 0.049	0.0GlyXaa: 0.0 ± 0.0
His	2.509HisAla: 2.509 ± 0.053	0.281HisCys: 0.281 ± 0.019	1.055HisAsp: 1.055 ± 0.033	1.252HisGlu: 1.252 ± 0.039	0.853HisPhe: 0.853 ± 0.033	2.119HisGly: 2.119 ± 0.047	0.636HisHis: 0.636 ± 0.029	0.895HisIle: 0.895 ± 0.031	0.565HisLys: 0.565 ± 0.024	2.478HisLeu: 2.478 ± 0.049	0.42HisMet: 0.42 ± 0.022	0.449HisAsn: 0.449 ± 0.022	1.712HisPro: 1.712 ± 0.045	0.714HisGln: 0.714 ± 0.025	1.781HisArg: 1.781 ± 0.045	0.896HisSer: 0.896 ± 0.031	0.915HisThr: 0.915 ± 0.033	1.661HisVal: 1.661 ± 0.047	0.36HisTrp: 0.36 ± 0.021	0.678HisTyr: 0.678 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.855IleAla: 5.855 ± 0.075	0.424IleCys: 0.424 ± 0.022	2.839IleAsp: 2.839 ± 0.057	3.474IleGlu: 3.474 ± 0.066	1.315IlePhe: 1.315 ± 0.039	3.999IleGly: 3.999 ± 0.072	1.014IleHis: 1.014 ± 0.03	1.728IleIle: 1.728 ± 0.051	1.653IleLys: 1.653 ± 0.046	4.258IleLeu: 4.258 ± 0.067	0.793IleMet: 0.793 ± 0.029	1.225IleAsn: 1.225 ± 0.035	2.5IlePro: 2.5 ± 0.062	1.409IleGln: 1.409 ± 0.043	3.441IleArg: 3.441 ± 0.067	2.023IleSer: 2.023 ± 0.052	2.231IleThr: 2.231 ± 0.05	3.881IleVal: 3.881 ± 0.063	0.398IleTrp: 0.398 ± 0.022	1.078IleTyr: 1.078 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.124LysAla: 4.124 ± 0.081	0.223LysCys: 0.223 ± 0.016	1.654LysAsp: 1.654 ± 0.044	2.18LysGlu: 2.18 ± 0.054	0.874LysPhe: 0.874 ± 0.032	2.585LysGly: 2.585 ± 0.061	0.686LysHis: 0.686 ± 0.029	1.598LysIle: 1.598 ± 0.05	1.493LysLys: 1.493 ± 0.063	3.555LysLeu: 3.555 ± 0.065	0.807LysMet: 0.807 ± 0.031	0.943LysAsn: 0.943 ± 0.038	2.153LysPro: 2.153 ± 0.052	1.186LysGln: 1.186 ± 0.04	2.938LysArg: 2.938 ± 0.059	1.645LysSer: 1.645 ± 0.047	1.883LysThr: 1.883 ± 0.047	2.632LysVal: 2.632 ± 0.064	0.37LysTrp: 0.37 ± 0.023	0.777LysTyr: 0.777 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	14.984LeuAla: 14.984 ± 0.17	0.904LeuCys: 0.904 ± 0.037	5.484LeuAsp: 5.484 ± 0.076	7.499LeuGlu: 7.499 ± 0.109	3.645LeuPhe: 3.645 ± 0.071	8.616LeuGly: 8.616 ± 0.12	2.251LeuHis: 2.251 ± 0.05	4.621LeuIle: 4.621 ± 0.072	4.556LeuLys: 4.556 ± 0.07	11.234LeuLeu: 11.234 ± 0.157	2.229LeuMet: 2.229 ± 0.049	2.497LeuAsn: 2.497 ± 0.054	6.111LeuPro: 6.111 ± 0.089	3.357LeuGln: 3.357 ± 0.066	8.271LeuArg: 8.271 ± 0.114	5.784LeuSer: 5.784 ± 0.086	5.422LeuThr: 5.422 ± 0.069	8.041LeuVal: 8.041 ± 0.101	1.368LeuTrp: 1.368 ± 0.042	2.519LeuTyr: 2.519 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.725MetAla: 2.725 ± 0.051	0.147MetCys: 0.147 ± 0.012	1.121MetAsp: 1.121 ± 0.035	1.424MetGlu: 1.424 ± 0.041	0.547MetPhe: 0.547 ± 0.025	1.768MetGly: 1.768 ± 0.044	0.436MetHis: 0.436 ± 0.021	1.008MetIle: 1.008 ± 0.037	1.04MetLys: 1.04 ± 0.035	2.294MetLeu: 2.294 ± 0.052	0.518MetMet: 0.518 ± 0.022	0.714MetAsn: 0.714 ± 0.029	1.266MetPro: 1.266 ± 0.036	0.771MetGln: 0.771 ± 0.031	1.806MetArg: 1.806 ± 0.042	1.207MetSer: 1.207 ± 0.034	1.318MetThr: 1.318 ± 0.041	1.623MetVal: 1.623 ± 0.046	0.188MetTrp: 0.188 ± 0.016	0.341MetTyr: 0.341 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.669AsnAla: 2.669 ± 0.058	0.254AsnCys: 0.254 ± 0.016	1.09AsnAsp: 1.09 ± 0.036	1.196AsnGlu: 1.196 ± 0.036	0.831AsnPhe: 0.831 ± 0.034	1.972AsnGly: 1.972 ± 0.049	0.478AsnHis: 0.478 ± 0.019	1.125AsnIle: 1.125 ± 0.036	0.708AsnLys: 0.708 ± 0.029	2.562AsnLeu: 2.562 ± 0.054	0.469AsnMet: 0.469 ± 0.024	0.557AsnAsn: 0.557 ± 0.023	1.985AsnPro: 1.985 ± 0.049	0.701AsnGln: 0.701 ± 0.027	1.92AsnArg: 1.92 ± 0.041	0.864AsnSer: 0.864 ± 0.032	1.116AsnThr: 1.116 ± 0.039	1.939AsnVal: 1.939 ± 0.051	0.329AsnTrp: 0.329 ± 0.019	0.615AsnTyr: 0.615 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	6.274ProAla: 6.274 ± 0.096	0.466ProCys: 0.466 ± 0.024	3.155ProAsp: 3.155 ± 0.058	4.298ProGlu: 4.298 ± 0.079	1.991ProPhe: 1.991 ± 0.045	4.895ProGly: 4.895 ± 0.064	1.186ProHis: 1.186 ± 0.039	2.061ProIle: 2.061 ± 0.057	1.765ProLys: 1.765 ± 0.042	5.422ProLeu: 5.422 ± 0.075	1.164ProMet: 1.164 ± 0.034	1.186ProAsn: 1.186 ± 0.037	3.086ProPro: 3.086 ± 0.075	1.906ProGln: 1.906 ± 0.047	3.658ProArg: 3.658 ± 0.068	2.663ProSer: 2.663 ± 0.055	2.293ProThr: 2.293 ± 0.045	4.559ProVal: 4.559 ± 0.068	0.799ProTrp: 0.799 ± 0.03	1.395ProTyr: 1.395 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.942GlnAla: 4.942 ± 0.088	0.309GlnCys: 0.309 ± 0.021	1.381GlnAsp: 1.381 ± 0.036	2.078GlnGlu: 2.078 ± 0.052	1.037GlnPhe: 1.037 ± 0.032	2.64GlnGly: 2.64 ± 0.053	0.692GlnHis: 0.692 ± 0.023	1.5GlnIle: 1.5 ± 0.041	1.186GlnLys: 1.186 ± 0.041	3.321GlnLeu: 3.321 ± 0.057	0.741GlnMet: 0.741 ± 0.026	0.692GlnAsn: 0.692 ± 0.028	1.756GlnPro: 1.756 ± 0.041	1.299GlnGln: 1.299 ± 0.045	2.971GlnArg: 2.971 ± 0.056	1.391GlnSer: 1.391 ± 0.039	1.514GlnThr: 1.514 ± 0.042	2.964GlnVal: 2.964 ± 0.057	0.512GlnTrp: 0.512 ± 0.025	0.752GlnTyr: 0.752 ± 0.03	0.0GlnXaa: 0.0 ± 0.0
Arg	8.606ArgAla: 8.606 ± 0.114	0.878ArgCys: 0.878 ± 0.034	3.732ArgAsp: 3.732 ± 0.065	5.756ArgGlu: 5.756 ± 0.089	3.321ArgPhe: 3.321 ± 0.059	5.498ArgGly: 5.498 ± 0.072	2.157ArgHis: 2.157 ± 0.054	4.117ArgIle: 4.117 ± 0.069	2.471ArgLys: 2.471 ± 0.052	10.417ArgLeu: 10.417 ± 0.136	1.876ArgMet: 1.876 ± 0.039	1.865ArgAsn: 1.865 ± 0.038	3.994ArgPro: 3.994 ± 0.068	3.035ArgGln: 3.035 ± 0.066	7.396ArgArg: 7.396 ± 0.09	3.641ArgSer: 3.641 ± 0.065	3.271ArgThr: 3.271 ± 0.048	6.202ArgVal: 6.202 ± 0.084	1.368ArgTrp: 1.368 ± 0.046	2.355ArgTyr: 2.355 ± 0.056	0.0ArgXaa: 0.0 ± 0.0
Ser	5.271SerAla: 5.271 ± 0.08	0.469SerCys: 0.469 ± 0.027	2.216SerAsp: 2.216 ± 0.045	2.552SerGlu: 2.552 ± 0.06	1.77SerPhe: 1.77 ± 0.045	4.657SerGly: 4.657 ± 0.07	1.033SerHis: 1.033 ± 0.029	2.153SerIle: 2.153 ± 0.057	1.39SerLys: 1.39 ± 0.039	5.164SerLeu: 5.164 ± 0.076	1.131SerMet: 1.131 ± 0.032	1.092SerAsn: 1.092 ± 0.039	2.787SerPro: 2.787 ± 0.056	1.498SerGln: 1.498 ± 0.043	3.895SerArg: 3.895 ± 0.06	2.363SerSer: 2.363 ± 0.057	2.121SerThr: 2.121 ± 0.052	3.509SerVal: 3.509 ± 0.067	0.623SerTrp: 0.623 ± 0.026	1.106SerTyr: 1.106 ± 0.034	0.0SerXaa: 0.0 ± 0.0
Thr	5.177ThrAla: 5.177 ± 0.08	0.494ThrCys: 0.494 ± 0.022	2.224ThrAsp: 2.224 ± 0.05	2.503ThrGlu: 2.503 ± 0.048	1.643ThrPhe: 1.643 ± 0.037	4.443ThrGly: 4.443 ± 0.073	0.999ThrHis: 0.999 ± 0.029	1.981ThrIle: 1.981 ± 0.055	1.155ThrLys: 1.155 ± 0.036	6.088ThrLeu: 6.088 ± 0.086	0.925ThrMet: 0.925 ± 0.031	0.97ThrAsn: 0.97 ± 0.035	3.173ThrPro: 3.173 ± 0.063	1.441ThrGln: 1.441 ± 0.042	3.511ThrArg: 3.511 ± 0.057	2.116ThrSer: 2.116 ± 0.048	2.28ThrThr: 2.28 ± 0.06	4.247ThrVal: 4.247 ± 0.064	0.615ThrTrp: 0.615 ± 0.025	1.121ThrTyr: 1.121 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	9.419ValAla: 9.419 ± 0.117	0.818ValCys: 0.818 ± 0.027	3.984ValAsp: 3.984 ± 0.069	5.256ValGlu: 5.256 ± 0.08	2.9ValPhe: 2.9 ± 0.056	5.774ValGly: 5.774 ± 0.091	1.655ValHis: 1.655 ± 0.042	3.983ValIle: 3.983 ± 0.07	2.797ValLys: 2.797 ± 0.058	8.409ValLeu: 8.409 ± 0.102	1.81ValMet: 1.81 ± 0.049	2.078ValAsn: 2.078 ± 0.052	4.178ValPro: 4.178 ± 0.063	2.401ValGln: 2.401 ± 0.046	5.97ValArg: 5.97 ± 0.073	4.125ValSer: 4.125 ± 0.062	4.201ValThr: 4.201 ± 0.069	6.924ValVal: 6.924 ± 0.107	1.037ValTrp: 1.037 ± 0.033	1.888ValTyr: 1.888 ± 0.044	0.0ValXaa: 0.0 ± 0.0
Trp	1.315TrpAla: 1.315 ± 0.039	0.186TrpCys: 0.186 ± 0.015	0.617TrpAsp: 0.617 ± 0.026	0.786TrpGlu: 0.786 ± 0.03	0.536TrpPhe: 0.536 ± 0.026	0.865TrpGly: 0.865 ± 0.032	0.371TrpHis: 0.371 ± 0.02	0.739TrpIle: 0.739 ± 0.029	0.529TrpLys: 0.529 ± 0.025	1.96TrpLeu: 1.96 ± 0.054	0.337TrpMet: 0.337 ± 0.019	0.396TrpAsn: 0.396 ± 0.02	0.658TrpPro: 0.658 ± 0.026	0.551TrpGln: 0.551 ± 0.025	1.302TrpArg: 1.302 ± 0.043	0.663TrpSer: 0.663 ± 0.024	0.664TrpThr: 0.664 ± 0.029	1.088TrpVal: 1.088 ± 0.037	0.241TrpTrp: 0.241 ± 0.018	0.365TrpTyr: 0.365 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.739TyrAla: 2.739 ± 0.056	0.298TyrCys: 0.298 ± 0.017	1.287TyrAsp: 1.287 ± 0.037	1.311TyrGlu: 1.311 ± 0.044	1.001TyrPhe: 1.001 ± 0.035	2.169TyrGly: 2.169 ± 0.047	0.649TyrHis: 0.649 ± 0.025	0.815TyrIle: 0.815 ± 0.033	0.682TyrLys: 0.682 ± 0.031	2.865TyrLeu: 2.865 ± 0.056	0.452TyrMet: 0.452 ± 0.021	0.618TyrAsn: 0.618 ± 0.028	1.38TyrPro: 1.38 ± 0.041	0.955TyrGln: 0.955 ± 0.028	2.364TyrArg: 2.364 ± 0.053	1.171TyrSer: 1.171 ± 0.04	1.22TyrThr: 1.22 ± 0.037	1.891TyrVal: 1.891 ± 0.046	0.388TyrTrp: 0.388 ± 0.021	0.805TyrTyr: 0.805 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3202 proteins (968774 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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