Amino acid dipepetide frequency for Sphingobium sp. CAP-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
19.185AlaAla: 19.185 ± 0.178
1.095AlaCys: 1.095 ± 0.027
8.244AlaAsp: 8.244 ± 0.08
6.721AlaGlu: 6.721 ± 0.089
4.427AlaPhe: 4.427 ± 0.057
11.461AlaGly: 11.461 ± 0.112
2.472AlaHis: 2.472 ± 0.045
7.137AlaIle: 7.137 ± 0.08
3.971AlaLys: 3.971 ± 0.07
14.328AlaLeu: 14.328 ± 0.132
4.124AlaMet: 4.124 ± 0.057
3.176AlaAsn: 3.176 ± 0.057
6.572AlaPro: 6.572 ± 0.1
5.162AlaGln: 5.162 ± 0.078
9.938AlaArg: 9.938 ± 0.101
6.562AlaSer: 6.562 ± 0.094
6.712AlaThr: 6.712 ± 0.101
8.216AlaVal: 8.216 ± 0.088
1.556AlaTrp: 1.556 ± 0.035
2.79AlaTyr: 2.79 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
1.091CysAla: 1.091 ± 0.032
0.1CysCys: 0.1 ± 0.008
0.506CysAsp: 0.506 ± 0.018
0.358CysGlu: 0.358 ± 0.017
0.279CysPhe: 0.279 ± 0.016
0.865CysGly: 0.865 ± 0.028
0.222CysHis: 0.222 ± 0.014
0.34CysIle: 0.34 ± 0.015
0.164CysLys: 0.164 ± 0.013
0.739CysLeu: 0.739 ± 0.024
0.16CysMet: 0.16 ± 0.011
0.2CysAsn: 0.2 ± 0.012
0.446CysPro: 0.446 ± 0.02
0.208CysGln: 0.208 ± 0.012
0.538CysArg: 0.538 ± 0.024
0.405CysSer: 0.405 ± 0.019
0.42CysThr: 0.42 ± 0.019
0.528CysVal: 0.528 ± 0.021
0.15CysTrp: 0.15 ± 0.011
0.202CysTyr: 0.202 ± 0.013
0.0CysXaa: 0.0 ± 0.0
Asp
8.252AspAla: 8.252 ± 0.081
0.48AspCys: 0.48 ± 0.019
3.459AspAsp: 3.459 ± 0.063
3.11AspGlu: 3.11 ± 0.06
2.188AspPhe: 2.188 ± 0.046
5.962AspGly: 5.962 ± 0.074
1.523AspHis: 1.523 ± 0.035
3.287AspIle: 3.287 ± 0.052
1.723AspLys: 1.723 ± 0.039
5.971AspLeu: 5.971 ± 0.085
1.712AspMet: 1.712 ± 0.035
1.49AspAsn: 1.49 ± 0.034
3.848AspPro: 3.848 ± 0.058
1.955AspGln: 1.955 ± 0.045
5.122AspArg: 5.122 ± 0.074
2.537AspSer: 2.537 ± 0.04
2.493AspThr: 2.493 ± 0.042
3.928AspVal: 3.928 ± 0.05
1.178AspTrp: 1.178 ± 0.03
1.849AspTyr: 1.849 ± 0.038
0.0AspXaa: 0.0 ± 0.0
Glu
7.132GluAla: 7.132 ± 0.093
0.288GluCys: 0.288 ± 0.016
2.421GluAsp: 2.421 ± 0.047
2.869GluGlu: 2.869 ± 0.062
1.303GluPhe: 1.303 ± 0.033
4.286GluGly: 4.286 ± 0.056
0.936GluHis: 0.936 ± 0.026
2.733GluIle: 2.733 ± 0.049
1.967GluLys: 1.967 ± 0.041
4.397GluLeu: 4.397 ± 0.053
1.399GluMet: 1.399 ± 0.034
1.288GluAsn: 1.288 ± 0.03
2.302GluPro: 2.302 ± 0.047
2.107GluGln: 2.107 ± 0.044
4.44GluArg: 4.44 ± 0.061
2.159GluSer: 2.159 ± 0.042
2.805GluThr: 2.805 ± 0.048
3.097GluVal: 3.097 ± 0.049
0.695GluTrp: 0.695 ± 0.025
0.913GluTyr: 0.913 ± 0.027
0.0GluXaa: 0.0 ± 0.0
Phe
4.746PheAla: 4.746 ± 0.07
0.349PheCys: 0.349 ± 0.017
2.694PheAsp: 2.694 ± 0.048
1.754PheGlu: 1.754 ± 0.035
1.272PhePhe: 1.272 ± 0.035
3.576PheGly: 3.576 ± 0.06
0.715PheHis: 0.715 ± 0.025
1.447PheIle: 1.447 ± 0.036
0.831PheLys: 0.831 ± 0.024
3.157PheLeu: 3.157 ± 0.051
0.745PheMet: 0.745 ± 0.024
1.021PheAsn: 1.021 ± 0.033
1.548PhePro: 1.548 ± 0.035
0.91PheGln: 0.91 ± 0.026
2.296PheArg: 2.296 ± 0.042
2.025PheSer: 2.025 ± 0.041
1.996PheThr: 1.996 ± 0.042
2.409PheVal: 2.409 ± 0.043
0.492PheTrp: 0.492 ± 0.02
0.942PheTyr: 0.942 ± 0.028
0.0PheXaa: 0.0 ± 0.0
Gly
10.348GlyAla: 10.348 ± 0.127
0.813GlyCys: 0.813 ± 0.029
5.235GlyAsp: 5.235 ± 0.073
4.468GlyGlu: 4.468 ± 0.063
3.629GlyPhe: 3.629 ± 0.049
8.263GlyGly: 8.263 ± 0.199
2.006GlyHis: 2.006 ± 0.043
4.422GlyIle: 4.422 ± 0.057
3.364GlyLys: 3.364 ± 0.064
8.792GlyLeu: 8.792 ± 0.094
2.37GlyMet: 2.37 ± 0.044
2.32GlyAsn: 2.32 ± 0.054
3.622GlyPro: 3.622 ± 0.049
3.289GlyGln: 3.289 ± 0.055
6.622GlyArg: 6.622 ± 0.076
4.76GlySer: 4.76 ± 0.103
4.533GlyThr: 4.533 ± 0.076
6.356GlyVal: 6.356 ± 0.068
1.709GlyTrp: 1.709 ± 0.036
2.449GlyTyr: 2.449 ± 0.055
0.0GlyXaa: 0.0 ± 0.0
His
2.397HisAla: 2.397 ± 0.043
0.211HisCys: 0.211 ± 0.012
1.279HisAsp: 1.279 ± 0.033
0.927HisGlu: 0.927 ± 0.026
0.842HisPhe: 0.842 ± 0.028
2.129HisGly: 2.129 ± 0.047
0.601HisHis: 0.601 ± 0.025
1.084HisIle: 1.084 ± 0.029
0.488HisLys: 0.488 ± 0.021
1.99HisLeu: 1.99 ± 0.038
0.564HisMet: 0.564 ± 0.021
0.455HisAsn: 0.455 ± 0.022
1.287HisPro: 1.287 ± 0.031
0.563HisGln: 0.563 ± 0.02
1.453HisArg: 1.453 ± 0.036
0.911HisSer: 0.911 ± 0.025
0.592HisThr: 0.592 ± 0.021
1.64HisVal: 1.64 ± 0.038
0.434HisTrp: 0.434 ± 0.019
0.661HisTyr: 0.661 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
8.147IleAla: 8.147 ± 0.078
0.436IleCys: 0.436 ± 0.019
4.227IleAsp: 4.227 ± 0.053
3.194IleGlu: 3.194 ± 0.051
1.797IlePhe: 1.797 ± 0.039
5.253IleGly: 5.253 ± 0.068
0.932IleHis: 0.932 ± 0.028
2.321IleIle: 2.321 ± 0.043
1.175IleLys: 1.175 ± 0.031
4.465IleLeu: 4.465 ± 0.057
0.982IleMet: 0.982 ± 0.026
1.364IleAsn: 1.364 ± 0.038
2.317IlePro: 2.317 ± 0.042
1.191IleGln: 1.191 ± 0.03
3.349IleArg: 3.349 ± 0.052
2.675IleSer: 2.675 ± 0.047
2.448IleThr: 2.448 ± 0.048
4.1IleVal: 4.1 ± 0.06
0.693IleTrp: 0.693 ± 0.025
1.016IleTyr: 1.016 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
4.342LysAla: 4.342 ± 0.07
0.146LysCys: 0.146 ± 0.01
1.677LysAsp: 1.677 ± 0.043
1.215LysGlu: 1.215 ± 0.034
0.793LysPhe: 0.793 ± 0.027
2.787LysGly: 2.787 ± 0.059
0.519LysHis: 0.519 ± 0.023
1.497LysIle: 1.497 ± 0.035
1.104LysLys: 1.104 ± 0.036
2.982LysLeu: 2.982 ± 0.057
0.729LysMet: 0.729 ± 0.025
0.755LysAsn: 0.755 ± 0.024
1.955LysPro: 1.955 ± 0.046
0.927LysGln: 0.927 ± 0.024
2.101LysArg: 2.101 ± 0.045
1.549LysSer: 1.549 ± 0.036
1.513LysThr: 1.513 ± 0.033
2.202LysVal: 2.202 ± 0.04
0.415LysTrp: 0.415 ± 0.02
0.607LysTyr: 0.607 ± 0.024
0.0LysXaa: 0.0 ± 0.0
Leu
13.572LeuAla: 13.572 ± 0.128
0.869LeuCys: 0.869 ± 0.03
6.098LeuAsp: 6.098 ± 0.069
4.431LeuGlu: 4.431 ± 0.072
3.714LeuPhe: 3.714 ± 0.063
8.06LeuGly: 8.06 ± 0.079
1.863LeuHis: 1.863 ± 0.04
5.221LeuIle: 5.221 ± 0.068
2.997LeuLys: 2.997 ± 0.052
9.983LeuLeu: 9.983 ± 0.132
2.27LeuMet: 2.27 ± 0.044
2.541LeuAsn: 2.541 ± 0.051
5.784LeuPro: 5.784 ± 0.068
2.395LeuGln: 2.395 ± 0.04
7.022LeuArg: 7.022 ± 0.095
6.366LeuSer: 6.366 ± 0.072
5.791LeuThr: 5.791 ± 0.068
6.676LeuVal: 6.676 ± 0.084
1.323LeuTrp: 1.323 ± 0.034
2.092LeuTyr: 2.092 ± 0.042
0.0LeuXaa: 0.0 ± 0.0
Met
3.593MetAla: 3.593 ± 0.056
0.14MetCys: 0.14 ± 0.009
1.251MetAsp: 1.251 ± 0.032
1.114MetGlu: 1.114 ± 0.033
0.684MetPhe: 0.684 ± 0.025
2.024MetGly: 2.024 ± 0.051
0.427MetHis: 0.427 ± 0.02
1.406MetIle: 1.406 ± 0.033
0.92MetLys: 0.92 ± 0.029
2.765MetLeu: 2.765 ± 0.049
0.698MetMet: 0.698 ± 0.023
0.67MetAsn: 0.67 ± 0.02
1.504MetPro: 1.504 ± 0.036
0.839MetGln: 0.839 ± 0.025
1.823MetArg: 1.823 ± 0.032
1.427MetSer: 1.427 ± 0.033
1.895MetThr: 1.895 ± 0.038
1.709MetVal: 1.709 ± 0.039
0.205MetTrp: 0.205 ± 0.013
0.251MetTyr: 0.251 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.313AsnAla: 3.313 ± 0.055
0.21AsnCys: 0.21 ± 0.012
1.492AsnAsp: 1.492 ± 0.037
1.032AsnGlu: 1.032 ± 0.028
0.952AsnPhe: 0.952 ± 0.029
2.575AsnGly: 2.575 ± 0.062
0.469AsnHis: 0.469 ± 0.018
1.409AsnIle: 1.409 ± 0.034
0.66AsnLys: 0.66 ± 0.02
2.446AsnLeu: 2.446 ± 0.045
0.597AsnMet: 0.597 ± 0.02
0.687AsnAsn: 0.687 ± 0.025
1.686AsnPro: 1.686 ± 0.046
0.766AsnGln: 0.766 ± 0.025
1.879AsnArg: 1.879 ± 0.039
1.315AsnSer: 1.315 ± 0.042
1.019AsnThr: 1.019 ± 0.032
1.896AsnVal: 1.896 ± 0.041
0.47AsnTrp: 0.47 ± 0.02
0.713AsnTyr: 0.713 ± 0.024
0.0AsnXaa: 0.0 ± 0.0
Pro
7.341ProAla: 7.341 ± 0.098
0.353ProCys: 0.353 ± 0.017
4.076ProAsp: 4.076 ± 0.064
3.046ProGlu: 3.046 ± 0.047
1.97ProPhe: 1.97 ± 0.037
4.77ProGly: 4.77 ± 0.063
1.125ProHis: 1.125 ± 0.033
2.558ProIle: 2.558 ± 0.045
1.452ProLys: 1.452 ± 0.034
4.954ProLeu: 4.954 ± 0.058
1.308ProMet: 1.308 ± 0.031
1.205ProAsn: 1.205 ± 0.033
2.799ProPro: 2.799 ± 0.062
1.859ProGln: 1.859 ± 0.039
3.03ProArg: 3.03 ± 0.05
2.702ProSer: 2.702 ± 0.048
2.647ProThr: 2.647 ± 0.045
4.351ProVal: 4.351 ± 0.062
0.723ProTrp: 0.723 ± 0.026
1.136ProTyr: 1.136 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.638GlnAla: 4.638 ± 0.064
0.249GlnCys: 0.249 ± 0.013
1.705GlnAsp: 1.705 ± 0.036
1.404GlnGlu: 1.404 ± 0.034
1.052GlnPhe: 1.052 ± 0.028
2.853GlnGly: 2.853 ± 0.046
0.598GlnHis: 0.598 ± 0.021
1.861GlnIle: 1.861 ± 0.04
0.985GlnLys: 0.985 ± 0.03
2.986GlnLeu: 2.986 ± 0.055
0.934GlnMet: 0.934 ± 0.029
0.818GlnAsn: 0.818 ± 0.025
1.896GlnPro: 1.896 ± 0.044
1.251GlnGln: 1.251 ± 0.037
2.546GlnArg: 2.546 ± 0.041
1.838GlnSer: 1.838 ± 0.041
1.629GlnThr: 1.629 ± 0.037
2.391GlnVal: 2.391 ± 0.042
0.498GlnTrp: 0.498 ± 0.02
0.69GlnTyr: 0.69 ± 0.025
0.0GlnXaa: 0.0 ± 0.0
Arg
9.048ArgAla: 9.048 ± 0.103
0.511ArgCys: 0.511 ± 0.021
4.453ArgAsp: 4.453 ± 0.064
3.53ArgGlu: 3.53 ± 0.062
3.06ArgPhe: 3.06 ± 0.048
5.094ArgGly: 5.094 ± 0.07
1.815ArgHis: 1.815 ± 0.035
4.331ArgIle: 4.331 ± 0.059
2.13ArgLys: 2.13 ± 0.044
8.201ArgLeu: 8.201 ± 0.097
1.861ArgMet: 1.861 ± 0.041
1.846ArgAsn: 1.846 ± 0.037
3.857ArgPro: 3.857 ± 0.06
2.681ArgGln: 2.681 ± 0.049
5.717ArgArg: 5.717 ± 0.088
3.637ArgSer: 3.637 ± 0.053
3.589ArgThr: 3.589 ± 0.051
4.603ArgVal: 4.603 ± 0.065
1.206ArgTrp: 1.206 ± 0.029
2.019ArgTyr: 2.019 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
6.647SerAla: 6.647 ± 0.09
0.423SerCys: 0.423 ± 0.02
3.192SerAsp: 3.192 ± 0.048
2.315SerGlu: 2.315 ± 0.045
2.162SerPhe: 2.162 ± 0.04
5.343SerGly: 5.343 ± 0.088
1.05SerHis: 1.05 ± 0.03
2.785SerIle: 2.785 ± 0.051
1.375SerLys: 1.375 ± 0.035
5.248SerLeu: 5.248 ± 0.076
1.181SerMet: 1.181 ± 0.03
1.329SerAsn: 1.329 ± 0.038
2.836SerPro: 2.836 ± 0.043
1.588SerGln: 1.588 ± 0.039
3.487SerArg: 3.487 ± 0.058
2.679SerSer: 2.679 ± 0.064
2.565SerThr: 2.565 ± 0.05
3.686SerVal: 3.686 ± 0.062
0.782SerTrp: 0.782 ± 0.023
1.442SerTyr: 1.442 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
6.159ThrAla: 6.159 ± 0.089
0.384ThrCys: 0.384 ± 0.018
3.083ThrAsp: 3.083 ± 0.043
2.045ThrGlu: 2.045 ± 0.039
1.631ThrPhe: 1.631 ± 0.036
5.295ThrGly: 5.295 ± 0.072
0.948ThrHis: 0.948 ± 0.031
3.054ThrIle: 3.054 ± 0.05
1.249ThrLys: 1.249 ± 0.029
5.908ThrLeu: 5.908 ± 0.067
1.149ThrMet: 1.149 ± 0.029
1.276ThrAsn: 1.276 ± 0.039
3.53ThrPro: 3.53 ± 0.052
1.571ThrGln: 1.571 ± 0.037
3.417ThrArg: 3.417 ± 0.052
2.552ThrSer: 2.552 ± 0.059
2.543ThrThr: 2.543 ± 0.052
3.939ThrVal: 3.939 ± 0.062
0.577ThrTrp: 0.577 ± 0.019
1.184ThrTyr: 1.184 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
9.599ValAla: 9.599 ± 0.095
0.491ValCys: 0.491 ± 0.022
4.523ValAsp: 4.523 ± 0.057
4.3ValGlu: 4.3 ± 0.061
1.731ValPhe: 1.731 ± 0.041
5.535ValGly: 5.535 ± 0.07
1.342ValHis: 1.342 ± 0.036
3.556ValIle: 3.556 ± 0.05
2.158ValLys: 2.158 ± 0.05
5.8ValLeu: 5.8 ± 0.06
1.694ValMet: 1.694 ± 0.038
2.041ValAsn: 2.041 ± 0.047
3.777ValPro: 3.777 ± 0.052
2.197ValGln: 2.197 ± 0.044
5.046ValArg: 5.046 ± 0.069
3.83ValSer: 3.83 ± 0.056
4.426ValThr: 4.426 ± 0.064
4.859ValVal: 4.859 ± 0.06
0.78ValTrp: 0.78 ± 0.025
1.371ValTyr: 1.371 ± 0.036
0.0ValXaa: 0.0 ± 0.0
Trp
1.426TrpAla: 1.426 ± 0.035
0.131TrpCys: 0.131 ± 0.01
0.77TrpAsp: 0.77 ± 0.026
0.59TrpGlu: 0.59 ± 0.022
0.532TrpPhe: 0.532 ± 0.02
0.974TrpGly: 0.974 ± 0.03
0.366TrpHis: 0.366 ± 0.017
0.74TrpIle: 0.74 ± 0.027
0.464TrpLys: 0.464 ± 0.016
1.74TrpLeu: 1.74 ± 0.042
0.38TrpMet: 0.38 ± 0.016
0.458TrpAsn: 0.458 ± 0.018
0.765TrpPro: 0.765 ± 0.025
0.604TrpGln: 0.604 ± 0.023
1.344TrpArg: 1.344 ± 0.03
0.918TrpSer: 0.918 ± 0.024
0.896TrpThr: 0.896 ± 0.03
0.87TrpVal: 0.87 ± 0.03
0.259TrpTrp: 0.259 ± 0.013
0.307TrpTyr: 0.307 ± 0.015
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.875TyrAla: 2.875 ± 0.045
0.244TyrCys: 0.244 ± 0.012
1.681TyrAsp: 1.681 ± 0.041
1.114TyrGlu: 1.114 ± 0.032
0.902TyrPhe: 0.902 ± 0.03
2.264TyrGly: 2.264 ± 0.047
0.578TyrHis: 0.578 ± 0.022
0.894TyrIle: 0.894 ± 0.026
0.639TyrLys: 0.639 ± 0.024
2.216TyrLeu: 2.216 ± 0.039
0.486TyrMet: 0.486 ± 0.019
0.647TyrAsn: 0.647 ± 0.028
1.074TyrPro: 1.074 ± 0.032
0.757TyrGln: 0.757 ± 0.025
2.018TyrArg: 2.018 ± 0.04
1.269TyrSer: 1.269 ± 0.04
0.983TyrThr: 0.983 ± 0.033
1.602TyrVal: 1.602 ± 0.034
0.389TyrTrp: 0.389 ± 0.02
0.687TyrTyr: 0.687 ± 0.027
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4137 proteins (1348542 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski