Amino acid dipepetide frequency for Thermoplasmatales archaeon Gpl

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.38AlaAla: 3.38 ± 0.106	0.38AlaCys: 0.38 ± 0.026	2.389AlaAsp: 2.389 ± 0.073	3.143AlaGlu: 3.143 ± 0.085	2.802AlaPhe: 2.802 ± 0.088	4.152AlaGly: 4.152 ± 0.111	0.755AlaHis: 0.755 ± 0.037	5.377AlaIle: 5.377 ± 0.113	3.327AlaLys: 3.327 ± 0.077	5.258AlaLeu: 5.258 ± 0.098	1.861AlaMet: 1.861 ± 0.062	2.167AlaAsn: 2.167 ± 0.067	1.46AlaPro: 1.46 ± 0.059	1.205AlaGln: 1.205 ± 0.046	2.58AlaArg: 2.58 ± 0.076	4.074AlaSer: 4.074 ± 0.093	2.82AlaThr: 2.82 ± 0.075	4.023AlaVal: 4.023 ± 0.104	0.427AlaTrp: 0.427 ± 0.03	2.087AlaTyr: 2.087 ± 0.062	0.002AlaXaa: 0.002 ± 0.002
Cys	0.354CysAla: 0.354 ± 0.026	0.076CysCys: 0.076 ± 0.014	0.39CysAsp: 0.39 ± 0.025	0.412CysGlu: 0.412 ± 0.03	0.261CysPhe: 0.261 ± 0.021	0.66CysGly: 0.66 ± 0.047	0.162CysHis: 0.162 ± 0.02	0.504CysIle: 0.504 ± 0.031	0.436CysLys: 0.436 ± 0.028	0.442CysLeu: 0.442 ± 0.033	0.173CysMet: 0.173 ± 0.017	0.386CysAsn: 0.386 ± 0.028	0.446CysPro: 0.446 ± 0.031	0.151CysGln: 0.151 ± 0.018	0.367CysArg: 0.367 ± 0.022	0.632CysSer: 0.632 ± 0.04	0.349CysThr: 0.349 ± 0.023	0.422CysVal: 0.422 ± 0.033	0.034CysTrp: 0.034 ± 0.007	0.28CysTyr: 0.28 ± 0.023	0.0CysXaa: 0.0 ± 0.0
Asp	2.589AspAla: 2.589 ± 0.074	0.358AspCys: 0.358 ± 0.025	2.384AspAsp: 2.384 ± 0.079	3.848AspGlu: 3.848 ± 0.097	2.727AspPhe: 2.727 ± 0.076	3.432AspGly: 3.432 ± 0.089	0.983AspHis: 0.983 ± 0.046	4.961AspIle: 4.961 ± 0.108	2.913AspLys: 2.913 ± 0.084	4.939AspLeu: 4.939 ± 0.105	1.6AspMet: 1.6 ± 0.057	2.083AspAsn: 2.083 ± 0.064	2.296AspPro: 2.296 ± 0.063	1.477AspGln: 1.477 ± 0.054	2.634AspArg: 2.634 ± 0.075	3.908AspSer: 3.908 ± 0.086	2.087AspThr: 2.087 ± 0.065	3.204AspVal: 3.204 ± 0.084	0.425AspTrp: 0.425 ± 0.031	2.335AspTyr: 2.335 ± 0.072	0.0AspXaa: 0.0 ± 0.0
Glu	3.361GluAla: 3.361 ± 0.095	0.403GluCys: 0.403 ± 0.029	3.507GluAsp: 3.507 ± 0.091	5.351GluGlu: 5.351 ± 0.119	2.938GluPhe: 2.938 ± 0.079	3.74GluGly: 3.74 ± 0.078	0.923GluHis: 0.923 ± 0.043	7.004GluIle: 7.004 ± 0.118	6.687GluLys: 6.687 ± 0.142	5.663GluLeu: 5.663 ± 0.104	2.425GluMet: 2.425 ± 0.075	4.501GluAsn: 4.501 ± 0.1	1.856GluPro: 1.856 ± 0.061	1.557GluGln: 1.557 ± 0.056	3.635GluArg: 3.635 ± 0.093	4.743GluSer: 4.743 ± 0.096	3.428GluThr: 3.428 ± 0.085	4.049GluVal: 4.049 ± 0.102	0.634GluTrp: 0.634 ± 0.04	2.54GluTyr: 2.54 ± 0.07	0.0GluXaa: 0.0 ± 0.0
Phe	2.533PheAla: 2.533 ± 0.064	0.328PheCys: 0.328 ± 0.027	2.283PheAsp: 2.283 ± 0.062	2.425PheGlu: 2.425 ± 0.07	2.557PhePhe: 2.557 ± 0.099	3.258PheGly: 3.258 ± 0.084	0.836PheHis: 0.836 ± 0.04	4.475PheIle: 4.475 ± 0.124	2.66PheLys: 2.66 ± 0.064	5.036PheLeu: 5.036 ± 0.129	1.395PheMet: 1.395 ± 0.052	2.658PheAsn: 2.658 ± 0.074	1.973PhePro: 1.973 ± 0.059	1.388PheGln: 1.388 ± 0.053	2.281PheArg: 2.281 ± 0.07	4.488PheSer: 4.488 ± 0.112	2.652PheThr: 2.652 ± 0.078	3.022PheVal: 3.022 ± 0.083	0.403PheTrp: 0.403 ± 0.028	2.117PheTyr: 2.117 ± 0.072	0.002PheXaa: 0.002 ± 0.002
Gly	3.872GlyAla: 3.872 ± 0.112	0.444GlyCys: 0.444 ± 0.027	3.154GlyAsp: 3.154 ± 0.074	4.053GlyGlu: 4.053 ± 0.092	3.628GlyPhe: 3.628 ± 0.094	4.704GlyGly: 4.704 ± 0.126	1.136GlyHis: 1.136 ± 0.048	7.045GlyIle: 7.045 ± 0.135	6.08GlyLys: 6.08 ± 0.119	5.657GlyLeu: 5.657 ± 0.109	2.19GlyMet: 2.19 ± 0.074	3.837GlyAsn: 3.837 ± 0.098	1.839GlyPro: 1.839 ± 0.062	1.543GlyGln: 1.543 ± 0.065	3.191GlyArg: 3.191 ± 0.079	5.407GlySer: 5.407 ± 0.112	4.072GlyThr: 4.072 ± 0.105	4.378GlyVal: 4.378 ± 0.09	0.657GlyTrp: 0.657 ± 0.035	2.997GlyTyr: 2.997 ± 0.093	0.002GlyXaa: 0.002 ± 0.002
His	0.714HisAla: 0.714 ± 0.035	0.121HisCys: 0.121 ± 0.016	0.727HisAsp: 0.727 ± 0.033	0.944HisGlu: 0.944 ± 0.043	0.746HisPhe: 0.746 ± 0.039	1.224HisGly: 1.224 ± 0.051	0.302HisHis: 0.302 ± 0.021	1.358HisIle: 1.358 ± 0.044	0.832HisLys: 0.832 ± 0.043	1.395HisLeu: 1.395 ± 0.06	0.459HisMet: 0.459 ± 0.03	0.754HisAsn: 0.754 ± 0.037	0.72HisPro: 0.72 ± 0.036	0.332HisGln: 0.332 ± 0.021	0.778HisArg: 0.778 ± 0.043	1.218HisSer: 1.218 ± 0.05	0.8HisThr: 0.8 ± 0.041	0.975HisVal: 0.975 ± 0.039	0.153HisTrp: 0.153 ± 0.018	0.625HisTyr: 0.625 ± 0.033	0.002HisXaa: 0.002 ± 0.002
Ile	5.282IleAla: 5.282 ± 0.106	0.696IleCys: 0.696 ± 0.038	4.788IleAsp: 4.788 ± 0.101	5.887IleGlu: 5.887 ± 0.107	4.551IlePhe: 4.551 ± 0.129	5.989IleGly: 5.989 ± 0.116	1.363IleHis: 1.363 ± 0.049	7.752IleIle: 7.752 ± 0.165	5.696IleLys: 5.696 ± 0.104	8.699IleLeu: 8.699 ± 0.187	2.587IleMet: 2.587 ± 0.076	4.628IleAsn: 4.628 ± 0.097	3.969IlePro: 3.969 ± 0.096	2.08IleGln: 2.08 ± 0.06	4.327IleArg: 4.327 ± 0.089	8.291IleSer: 8.291 ± 0.144	4.665IleThr: 4.665 ± 0.106	5.655IleVal: 5.655 ± 0.115	0.634IleTrp: 0.634 ± 0.036	3.618IleTyr: 3.618 ± 0.103	0.004IleXaa: 0.004 ± 0.003
Lys	3.471LysAla: 3.471 ± 0.091	0.573LysCys: 0.573 ± 0.038	3.906LysAsp: 3.906 ± 0.104	5.881LysGlu: 5.881 ± 0.134	2.971LysPhe: 2.971 ± 0.081	4.409LysGly: 4.409 ± 0.09	0.906LysHis: 0.906 ± 0.047	6.823LysIle: 6.823 ± 0.118	6.159LysLys: 6.159 ± 0.127	5.762LysLeu: 5.762 ± 0.122	2.305LysMet: 2.305 ± 0.072	4.614LysAsn: 4.614 ± 0.09	2.136LysPro: 2.136 ± 0.065	1.451LysGln: 1.451 ± 0.061	3.393LysArg: 3.393 ± 0.089	4.764LysSer: 4.764 ± 0.098	3.659LysThr: 3.659 ± 0.085	4.128LysVal: 4.128 ± 0.101	0.679LysTrp: 0.679 ± 0.035	3.053LysTyr: 3.053 ± 0.081	0.0LysXaa: 0.0 ± 0.0
Leu	4.896LeuAla: 4.896 ± 0.117	0.591LeuCys: 0.591 ± 0.036	4.4LeuAsp: 4.4 ± 0.099	5.568LeuGlu: 5.568 ± 0.122	4.236LeuPhe: 4.236 ± 0.127	6.077LeuGly: 6.077 ± 0.121	1.214LeuHis: 1.214 ± 0.05	7.772LeuIle: 7.772 ± 0.173	7.306LeuLys: 7.306 ± 0.122	7.849LeuLeu: 7.849 ± 0.159	2.734LeuMet: 2.734 ± 0.071	5.079LeuAsn: 5.079 ± 0.112	3.264LeuPro: 3.264 ± 0.083	2.102LeuGln: 2.102 ± 0.058	4.163LeuArg: 4.163 ± 0.09	7.957LeuSer: 7.957 ± 0.159	4.695LeuThr: 4.695 ± 0.1	5.098LeuVal: 5.098 ± 0.096	0.774LeuTrp: 0.774 ± 0.04	3.141LeuTyr: 3.141 ± 0.086	0.004LeuXaa: 0.004 ± 0.003
Met	2.085MetAla: 2.085 ± 0.07	0.164MetCys: 0.164 ± 0.016	1.975MetAsp: 1.975 ± 0.062	2.818MetGlu: 2.818 ± 0.071	1.11MetPhe: 1.11 ± 0.045	2.216MetGly: 2.216 ± 0.063	0.433MetHis: 0.433 ± 0.027	2.533MetIle: 2.533 ± 0.072	2.686MetLys: 2.686 ± 0.074	2.221MetLeu: 2.221 ± 0.069	0.815MetMet: 0.815 ± 0.039	1.942MetAsn: 1.942 ± 0.064	1.1MetPro: 1.1 ± 0.047	0.698MetGln: 0.698 ± 0.038	1.442MetArg: 1.442 ± 0.044	2.106MetSer: 2.106 ± 0.059	1.449MetThr: 1.449 ± 0.048	2.039MetVal: 2.039 ± 0.058	0.233MetTrp: 0.233 ± 0.023	0.795MetTyr: 0.795 ± 0.037	0.0MetXaa: 0.0 ± 0.0
Asn	2.693AsnAla: 2.693 ± 0.082	0.38AsnCys: 0.38 ± 0.028	2.417AsnAsp: 2.417 ± 0.068	3.518AsnGlu: 3.518 ± 0.088	2.807AsnPhe: 2.807 ± 0.071	4.079AsnGly: 4.079 ± 0.132	0.847AsnHis: 0.847 ± 0.042	4.993AsnIle: 4.993 ± 0.099	2.964AsnLys: 2.964 ± 0.069	5.223AsnLeu: 5.223 ± 0.103	1.72AsnMet: 1.72 ± 0.051	2.678AsnAsn: 2.678 ± 0.087	2.367AsnPro: 2.367 ± 0.073	1.289AsnGln: 1.289 ± 0.057	2.363AsnArg: 2.363 ± 0.062	4.282AsnSer: 4.282 ± 0.103	2.55AsnThr: 2.55 ± 0.081	3.339AsnVal: 3.339 ± 0.082	0.42AsnTrp: 0.42 ± 0.022	2.414AsnTyr: 2.414 ± 0.071	0.0AsnXaa: 0.0 ± 0.0
Pro	1.893ProAla: 1.893 ± 0.061	0.222ProCys: 0.222 ± 0.019	2.4ProAsp: 2.4 ± 0.065	3.382ProGlu: 3.382 ± 0.084	1.802ProPhe: 1.802 ± 0.055	2.537ProGly: 2.537 ± 0.086	0.606ProHis: 0.606 ± 0.034	2.451ProIle: 2.451 ± 0.072	1.792ProLys: 1.792 ± 0.062	3.189ProLeu: 3.189 ± 0.077	1.007ProMet: 1.007 ± 0.041	1.423ProAsn: 1.423 ± 0.061	1.121ProPro: 1.121 ± 0.047	0.925ProGln: 0.925 ± 0.047	1.248ProArg: 1.248 ± 0.048	2.738ProSer: 2.738 ± 0.084	1.619ProThr: 1.619 ± 0.06	3.066ProVal: 3.066 ± 0.074	0.384ProTrp: 0.384 ± 0.027	1.623ProTyr: 1.623 ± 0.059	0.004ProXaa: 0.004 ± 0.003
Gln	1.233GlnAla: 1.233 ± 0.05	0.151GlnCys: 0.151 ± 0.018	1.127GlnAsp: 1.127 ± 0.043	1.667GlnGlu: 1.667 ± 0.059	1.168GlnPhe: 1.168 ± 0.056	1.369GlnGly: 1.369 ± 0.053	0.313GlnHis: 0.313 ± 0.026	2.376GlnIle: 2.376 ± 0.063	1.998GlnLys: 1.998 ± 0.064	1.897GlnLeu: 1.897 ± 0.056	0.843GlnMet: 0.843 ± 0.046	1.404GlnAsn: 1.404 ± 0.059	0.66GlnPro: 0.66 ± 0.034	0.578GlnGln: 0.578 ± 0.034	1.1GlnArg: 1.1 ± 0.048	1.74GlnSer: 1.74 ± 0.055	1.181GlnThr: 1.181 ± 0.044	1.347GlnVal: 1.347 ± 0.053	0.282GlnTrp: 0.282 ± 0.023	0.948GlnTyr: 0.948 ± 0.05	0.002GlnXaa: 0.002 ± 0.002
Arg	2.354ArgAla: 2.354 ± 0.068	0.351ArgCys: 0.351 ± 0.03	2.718ArgAsp: 2.718 ± 0.072	4.176ArgGlu: 4.176 ± 0.103	1.96ArgPhe: 1.96 ± 0.061	2.932ArgGly: 2.932 ± 0.073	0.606ArgHis: 0.606 ± 0.035	4.391ArgIle: 4.391 ± 0.102	4.519ArgLys: 4.519 ± 0.092	3.402ArgLeu: 3.402 ± 0.089	1.598ArgMet: 1.598 ± 0.058	2.962ArgAsn: 2.962 ± 0.079	1.266ArgPro: 1.266 ± 0.057	1.003ArgGln: 1.003 ± 0.049	2.443ArgArg: 2.443 ± 0.082	3.078ArgSer: 3.078 ± 0.075	2.387ArgThr: 2.387 ± 0.067	2.824ArgVal: 2.824 ± 0.086	0.384ArgTrp: 0.384 ± 0.028	1.75ArgTyr: 1.75 ± 0.049	0.002ArgXaa: 0.002 ± 0.002
Ser	3.913SerAla: 3.913 ± 0.083	0.502SerCys: 0.502 ± 0.035	3.937SerAsp: 3.937 ± 0.096	5.189SerGlu: 5.189 ± 0.108	4.165SerPhe: 4.165 ± 0.106	6.62SerGly: 6.62 ± 0.123	1.212SerHis: 1.212 ± 0.043	7.159SerIle: 7.159 ± 0.127	4.922SerLys: 4.922 ± 0.104	7.535SerLeu: 7.535 ± 0.13	2.499SerMet: 2.499 ± 0.068	3.844SerAsn: 3.844 ± 0.109	2.622SerPro: 2.622 ± 0.071	1.899SerGln: 1.899 ± 0.055	3.689SerArg: 3.689 ± 0.08	6.439SerSer: 6.439 ± 0.144	4.13SerThr: 4.13 ± 0.091	5.103SerVal: 5.103 ± 0.122	0.712SerTrp: 0.712 ± 0.034	3.346SerTyr: 3.346 ± 0.1	0.002SerXaa: 0.002 ± 0.002
Thr	2.891ThrAla: 2.891 ± 0.079	0.297ThrCys: 0.297 ± 0.027	2.671ThrAsp: 2.671 ± 0.066	3.268ThrGlu: 3.268 ± 0.089	2.58ThrPhe: 2.58 ± 0.078	4.685ThrGly: 4.685 ± 0.109	0.813ThrHis: 0.813 ± 0.04	4.251ThrIle: 4.251 ± 0.089	2.79ThrLys: 2.79 ± 0.066	4.631ThrLeu: 4.631 ± 0.099	1.475ThrMet: 1.475 ± 0.051	2.311ThrAsn: 2.311 ± 0.077	2.007ThrPro: 2.007 ± 0.057	1.227ThrGln: 1.227 ± 0.049	2.083ThrArg: 2.083 ± 0.068	3.74ThrSer: 3.74 ± 0.104	2.742ThrThr: 2.742 ± 0.088	4.098ThrVal: 4.098 ± 0.105	0.394ThrTrp: 0.394 ± 0.026	2.169ThrTyr: 2.169 ± 0.068	0.0ThrXaa: 0.0 ± 0.0
Val	3.648ValAla: 3.648 ± 0.088	0.507ValCys: 0.507 ± 0.029	3.387ValAsp: 3.387 ± 0.083	4.273ValGlu: 4.273 ± 0.099	3.091ValPhe: 3.091 ± 0.08	4.042ValGly: 4.042 ± 0.09	0.931ValHis: 0.931 ± 0.041	5.873ValIle: 5.873 ± 0.115	4.596ValLys: 4.596 ± 0.11	5.456ValLeu: 5.456 ± 0.097	1.917ValMet: 1.917 ± 0.055	3.413ValAsn: 3.413 ± 0.085	2.486ValPro: 2.486 ± 0.075	1.328ValGln: 1.328 ± 0.047	2.986ValArg: 2.986 ± 0.074	5.543ValSer: 5.543 ± 0.111	3.432ValThr: 3.432 ± 0.087	4.288ValVal: 4.288 ± 0.105	0.539ValTrp: 0.539 ± 0.033	2.522ValTyr: 2.522 ± 0.075	0.002ValXaa: 0.002 ± 0.002
Trp	0.435TrpAla: 0.435 ± 0.029	0.063TrpCys: 0.063 ± 0.009	0.474TrpAsp: 0.474 ± 0.035	0.546TrpGlu: 0.546 ± 0.035	0.418TrpPhe: 0.418 ± 0.028	0.571TrpGly: 0.571 ± 0.035	0.132TrpHis: 0.132 ± 0.015	0.886TrpIle: 0.886 ± 0.046	0.763TrpLys: 0.763 ± 0.042	0.699TrpLeu: 0.699 ± 0.028	0.257TrpMet: 0.257 ± 0.023	0.601TrpAsn: 0.601 ± 0.032	0.284TrpPro: 0.284 ± 0.026	0.235TrpGln: 0.235 ± 0.02	0.39TrpArg: 0.39 ± 0.029	0.604TrpSer: 0.604 ± 0.031	0.328TrpThr: 0.328 ± 0.024	0.533TrpVal: 0.533 ± 0.033	0.093TrpTrp: 0.093 ± 0.013	0.345TrpTyr: 0.345 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.07TyrAla: 2.07 ± 0.073	0.33TyrCys: 0.33 ± 0.027	2.151TyrAsp: 2.151 ± 0.065	2.596TyrGlu: 2.596 ± 0.076	2.253TyrPhe: 2.253 ± 0.066	3.188TyrGly: 3.188 ± 0.07	0.701TyrHis: 0.701 ± 0.033	3.176TyrIle: 3.176 ± 0.078	1.917TyrLys: 1.917 ± 0.061	3.962TyrLeu: 3.962 ± 0.105	0.994TyrMet: 0.994 ± 0.048	2.054TyrAsn: 2.054 ± 0.073	1.557TyrPro: 1.557 ± 0.055	0.914TyrGln: 0.914 ± 0.041	2.013TyrArg: 2.013 ± 0.063	3.689TyrSer: 3.689 ± 0.097	2.072TyrThr: 2.072 ± 0.074	2.671TyrVal: 2.671 ± 0.075	0.397TyrTrp: 0.397 ± 0.031	1.968TyrTyr: 1.968 ± 0.081	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.002	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.002XaaGly: 0.002 ± 0.002	0.002XaaHis: 0.002 ± 0.002	0.002XaaIle: 0.002 ± 0.002	0.0XaaLys: 0.0 ± 0.0	0.004XaaLeu: 0.004 ± 0.002	0.0XaaMet: 0.0 ± 0.0	0.004XaaAsn: 0.004 ± 0.003	0.002XaaPro: 0.002 ± 0.002	0.002XaaGln: 0.002 ± 0.002	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.006XaaThr: 0.006 ± 0.003	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.002XaaTyr: 0.002 ± 0.002	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 1917 proteins (536142 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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