Amino acid dipepetide frequency for Crocosphaera subtropica (strain ATCC 51142 / BH68) (Cyanothece sp. (strain ATCC 51142))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	4.892AlaAla: 4.892 ± 0.063	0.686AlaCys: 0.686 ± 0.023	3.24AlaAsp: 3.24 ± 0.055	4.179AlaGlu: 4.179 ± 0.062	2.679AlaPhe: 2.679 ± 0.041	4.122AlaGly: 4.122 ± 0.069	1.054AlaHis: 1.054 ± 0.028	5.949AlaIle: 5.949 ± 0.067	3.983AlaLys: 3.983 ± 0.057	7.265AlaLeu: 7.265 ± 0.078	1.578AlaMet: 1.578 ± 0.03	3.012AlaAsn: 3.012 ± 0.051	2.039AlaPro: 2.039 ± 0.041	3.348AlaGln: 3.348 ± 0.048	2.573AlaArg: 2.573 ± 0.041	3.849AlaSer: 3.849 ± 0.054	3.817AlaThr: 3.817 ± 0.06	4.392AlaVal: 4.392 ± 0.066	0.889AlaTrp: 0.889 ± 0.023	2.201AlaTyr: 2.201 ± 0.038	0.0AlaXaa: 0.0 ± 0.0
Cys	0.534CysAla: 0.534 ± 0.022	0.187CysCys: 0.187 ± 0.01	0.559CysAsp: 0.559 ± 0.02	0.522CysGlu: 0.522 ± 0.018	0.484CysPhe: 0.484 ± 0.019	0.731CysGly: 0.731 ± 0.022	0.326CysHis: 0.326 ± 0.017	0.553CysIle: 0.553 ± 0.018	0.335CysLys: 0.335 ± 0.015	1.314CysLeu: 1.314 ± 0.032	0.144CysMet: 0.144 ± 0.01	0.385CysAsn: 0.385 ± 0.014	0.536CysPro: 0.536 ± 0.021	0.68CysGln: 0.68 ± 0.023	0.514CysArg: 0.514 ± 0.019	0.608CysSer: 0.608 ± 0.02	0.469CysThr: 0.469 ± 0.019	0.553CysVal: 0.553 ± 0.018	0.139CysTrp: 0.139 ± 0.01	0.425CysTyr: 0.425 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	2.93AspAla: 2.93 ± 0.049	0.529AspCys: 0.529 ± 0.019	2.466AspAsp: 2.466 ± 0.046	3.211AspGlu: 3.211 ± 0.061	2.475AspPhe: 2.475 ± 0.046	3.201AspGly: 3.201 ± 0.071	1.03AspHis: 1.03 ± 0.028	3.97AspIle: 3.97 ± 0.054	2.698AspLys: 2.698 ± 0.05	5.608AspLeu: 5.608 ± 0.075	0.847AspMet: 0.847 ± 0.023	2.801AspAsn: 2.801 ± 0.047	2.635AspPro: 2.635 ± 0.049	2.089AspGln: 2.089 ± 0.038	2.705AspArg: 2.705 ± 0.048	3.057AspSer: 3.057 ± 0.049	2.495AspThr: 2.495 ± 0.052	2.867AspVal: 2.867 ± 0.048	0.876AspTrp: 0.876 ± 0.024	2.288AspTyr: 2.288 ± 0.041	0.0AspXaa: 0.0 ± 0.0
Glu	5.112GluAla: 5.112 ± 0.069	0.443GluCys: 0.443 ± 0.02	3.262GluAsp: 3.262 ± 0.052	4.976GluGlu: 4.976 ± 0.068	2.356GluPhe: 2.356 ± 0.044	3.681GluGly: 3.681 ± 0.055	0.976GluHis: 0.976 ± 0.026	5.405GluIle: 5.405 ± 0.065	4.769GluLys: 4.769 ± 0.07	6.649GluLeu: 6.649 ± 0.071	1.473GluMet: 1.473 ± 0.031	3.427GluAsn: 3.427 ± 0.05	2.312GluPro: 2.312 ± 0.045	3.685GluGln: 3.685 ± 0.057	2.914GluArg: 2.914 ± 0.048	3.478GluSer: 3.478 ± 0.045	4.523GluThr: 4.523 ± 0.068	4.191GluVal: 4.191 ± 0.064	0.77GluTrp: 0.77 ± 0.021	1.808GluTyr: 1.808 ± 0.042	0.0GluXaa: 0.0 ± 0.0
Phe	2.623PheAla: 2.623 ± 0.04	0.571PheCys: 0.571 ± 0.019	2.445PheAsp: 2.445 ± 0.044	2.429PheGlu: 2.429 ± 0.043	1.95PhePhe: 1.95 ± 0.041	2.769PheGly: 2.769 ± 0.055	0.727PheHis: 0.727 ± 0.022	2.943PheIle: 2.943 ± 0.045	1.931PheLys: 1.931 ± 0.038	4.565PheLeu: 4.565 ± 0.077	0.82PheMet: 0.82 ± 0.022	2.152PheAsn: 2.152 ± 0.038	1.959PhePro: 1.959 ± 0.035	1.752PheGln: 1.752 ± 0.03	1.742PheArg: 1.742 ± 0.035	3.208PheSer: 3.208 ± 0.049	2.249PheThr: 2.249 ± 0.043	2.327PheVal: 2.327 ± 0.041	0.721PheTrp: 0.721 ± 0.023	1.527PheTyr: 1.527 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	3.742GlyAla: 3.742 ± 0.061	0.743GlyCys: 0.743 ± 0.019	3.389GlyAsp: 3.389 ± 0.067	4.07GlyGlu: 4.07 ± 0.063	3.049GlyPhe: 3.049 ± 0.05	4.517GlyGly: 4.517 ± 0.085	1.284GlyHis: 1.284 ± 0.033	5.242GlyIle: 5.242 ± 0.056	4.169GlyLys: 4.169 ± 0.061	6.944GlyLeu: 6.944 ± 0.076	1.502GlyMet: 1.502 ± 0.034	3.103GlyAsn: 3.103 ± 0.074	1.283GlyPro: 1.283 ± 0.031	2.976GlyGln: 2.976 ± 0.045	2.671GlyArg: 2.671 ± 0.047	3.813GlySer: 3.813 ± 0.053	3.875GlyThr: 3.875 ± 0.085	4.482GlyVal: 4.482 ± 0.062	1.077GlyTrp: 1.077 ± 0.027	2.41GlyTyr: 2.41 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	0.85HisAla: 0.85 ± 0.022	0.304HisCys: 0.304 ± 0.012	0.873HisAsp: 0.873 ± 0.023	0.978HisGlu: 0.978 ± 0.024	0.897HisPhe: 0.897 ± 0.025	1.128HisGly: 1.128 ± 0.028	0.765HisHis: 0.765 ± 0.03	1.177HisIle: 1.177 ± 0.03	0.823HisLys: 0.823 ± 0.022	2.291HisLeu: 2.291 ± 0.041	0.237HisMet: 0.237 ± 0.013	0.878HisAsn: 0.878 ± 0.03	1.341HisPro: 1.341 ± 0.033	1.323HisGln: 1.323 ± 0.03	1.092HisArg: 1.092 ± 0.027	1.223HisSer: 1.223 ± 0.028	0.886HisThr: 0.886 ± 0.028	0.714HisVal: 0.714 ± 0.021	0.393HisTrp: 0.393 ± 0.017	0.791HisTyr: 0.791 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.115IleAla: 6.115 ± 0.073	0.74IleCys: 0.74 ± 0.024	4.251IleAsp: 4.251 ± 0.056	5.22IleGlu: 5.22 ± 0.062	3.031IlePhe: 3.031 ± 0.056	4.586IleGly: 4.586 ± 0.068	1.271IleHis: 1.271 ± 0.029	5.83IleIle: 5.83 ± 0.074	4.125IleLys: 4.125 ± 0.052	7.844IleLeu: 7.844 ± 0.084	1.269IleMet: 1.269 ± 0.028	4.07IleAsn: 4.07 ± 0.069	3.883IlePro: 3.883 ± 0.05	2.941IleGln: 2.941 ± 0.042	3.18IleArg: 3.18 ± 0.048	4.868IleSer: 4.868 ± 0.061	4.391IleThr: 4.391 ± 0.053	4.278IleVal: 4.278 ± 0.057	0.896IleTrp: 0.896 ± 0.03	2.301IleTyr: 2.301 ± 0.047	0.0IleXaa: 0.0 ± 0.0
Lys	3.919LysAla: 3.919 ± 0.053	0.358LysCys: 0.358 ± 0.016	2.715LysAsp: 2.715 ± 0.045	3.941LysGlu: 3.941 ± 0.063	1.772LysPhe: 1.772 ± 0.039	3.131LysGly: 3.131 ± 0.051	0.942LysHis: 0.942 ± 0.027	4.558LysIle: 4.558 ± 0.057	3.641LysLys: 3.641 ± 0.058	5.837LysLeu: 5.837 ± 0.071	1.201LysMet: 1.201 ± 0.027	2.904LysAsn: 2.904 ± 0.051	2.488LysPro: 2.488 ± 0.043	3.291LysGln: 3.291 ± 0.054	2.64LysArg: 2.64 ± 0.041	3.16LysSer: 3.16 ± 0.045	3.629LysThr: 3.629 ± 0.052	3.489LysVal: 3.489 ± 0.051	0.557LysTrp: 0.557 ± 0.018	1.565LysTyr: 1.565 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	7.906LeuAla: 7.906 ± 0.072	1.048LeuCys: 1.048 ± 0.029	5.612LeuAsp: 5.612 ± 0.07	7.979LeuGlu: 7.979 ± 0.087	4.144LeuPhe: 4.144 ± 0.066	7.653LeuGly: 7.653 ± 0.082	1.68LeuHis: 1.68 ± 0.04	7.949LeuIle: 7.949 ± 0.093	6.596LeuLys: 6.596 ± 0.071	11.417LeuLeu: 11.417 ± 0.12	2.362LeuMet: 2.362 ± 0.045	5.244LeuAsn: 5.244 ± 0.066	5.282LeuPro: 5.282 ± 0.065	4.959LeuGln: 4.959 ± 0.06	4.748LeuArg: 4.748 ± 0.052	8.18LeuSer: 8.18 ± 0.083	7.004LeuThr: 7.004 ± 0.075	6.66LeuVal: 6.66 ± 0.064	1.429LeuTrp: 1.429 ± 0.039	2.874LeuTyr: 2.874 ± 0.045	0.0LeuXaa: 0.0 ± 0.0
Met	1.692MetAla: 1.692 ± 0.035	0.142MetCys: 0.142 ± 0.009	0.816MetAsp: 0.816 ± 0.024	1.083MetGlu: 1.083 ± 0.027	0.623MetPhe: 0.623 ± 0.021	1.609MetGly: 1.609 ± 0.035	0.218MetHis: 0.218 ± 0.012	1.63MetIle: 1.63 ± 0.034	1.244MetLys: 1.244 ± 0.029	1.912MetLeu: 1.912 ± 0.042	0.593MetMet: 0.593 ± 0.02	1.05MetAsn: 1.05 ± 0.025	0.767MetPro: 0.767 ± 0.023	0.652MetGln: 0.652 ± 0.022	0.883MetArg: 0.883 ± 0.022	1.443MetSer: 1.443 ± 0.026	1.545MetThr: 1.545 ± 0.036	1.458MetVal: 1.458 ± 0.032	0.168MetTrp: 0.168 ± 0.011	0.406MetTyr: 0.406 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.738AsnAla: 2.738 ± 0.047	0.566AsnCys: 0.566 ± 0.02	2.168AsnAsp: 2.168 ± 0.057	2.305AsnGlu: 2.305 ± 0.044	2.234AsnPhe: 2.234 ± 0.037	2.692AsnGly: 2.692 ± 0.059	1.236AsnHis: 1.236 ± 0.034	3.487AsnIle: 3.487 ± 0.055	2.406AsnLys: 2.406 ± 0.042	6.16AsnLeu: 6.16 ± 0.092	0.835AsnMet: 0.835 ± 0.025	3.076AsnAsn: 3.076 ± 0.065	3.058AsnPro: 3.058 ± 0.049	3.024AsnGln: 3.024 ± 0.049	2.337AsnArg: 2.337 ± 0.041	3.253AsnSer: 3.253 ± 0.056	2.511AsnThr: 2.511 ± 0.043	2.305AsnVal: 2.305 ± 0.044	0.823AsnTrp: 0.823 ± 0.025	2.052AsnTyr: 2.052 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.054ProAla: 2.054 ± 0.036	0.372ProCys: 0.372 ± 0.016	2.824ProAsp: 2.824 ± 0.042	3.662ProGlu: 3.662 ± 0.051	1.885ProPhe: 1.885 ± 0.037	2.639ProGly: 2.639 ± 0.05	0.982ProHis: 0.982 ± 0.028	3.406ProIle: 3.406 ± 0.052	2.335ProLys: 2.335 ± 0.041	4.902ProLeu: 4.902 ± 0.071	0.814ProMet: 0.814 ± 0.022	2.51ProAsn: 2.51 ± 0.047	2.133ProPro: 2.133 ± 0.059	2.509ProGln: 2.509 ± 0.047	1.637ProArg: 1.637 ± 0.036	3.041ProSer: 3.041 ± 0.049	2.598ProThr: 2.598 ± 0.043	2.786ProVal: 2.786 ± 0.044	0.634ProTrp: 0.634 ± 0.02	1.546ProTyr: 1.546 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	3.683GlnAla: 3.683 ± 0.055	0.425GlnCys: 0.425 ± 0.016	2.323GlnAsp: 2.323 ± 0.038	4.087GlnGlu: 4.087 ± 0.063	1.942GlnPhe: 1.942 ± 0.039	3.63GlnGly: 3.63 ± 0.049	0.759GlnHis: 0.759 ± 0.023	3.236GlnIle: 3.236 ± 0.051	3.197GlnLys: 3.197 ± 0.059	5.915GlnLeu: 5.915 ± 0.073	0.989GlnMet: 0.989 ± 0.026	1.989GlnAsn: 1.989 ± 0.043	2.254GlnPro: 2.254 ± 0.042	3.629GlnGln: 3.629 ± 0.064	2.547GlnArg: 2.547 ± 0.048	2.811GlnSer: 2.811 ± 0.049	3.117GlnThr: 3.117 ± 0.051	3.265GlnVal: 3.265 ± 0.049	0.88GlnTrp: 0.88 ± 0.026	1.399GlnTyr: 1.399 ± 0.032	0.0GlnXaa: 0.0 ± 0.0
Arg	2.214ArgAla: 2.214 ± 0.039	0.472ArgCys: 0.472 ± 0.019	2.239ArgAsp: 2.239 ± 0.043	3.015ArgGlu: 3.015 ± 0.047	2.08ArgPhe: 2.08 ± 0.039	2.626ArgGly: 2.626 ± 0.044	0.986ArgHis: 0.986 ± 0.023	3.141ArgIle: 3.141 ± 0.045	2.445ArgLys: 2.445 ± 0.047	5.303ArgLeu: 5.303 ± 0.067	0.883ArgMet: 0.883 ± 0.024	2.118ArgAsn: 2.118 ± 0.039	1.801ArgPro: 1.801 ± 0.036	2.782ArgGln: 2.782 ± 0.042	2.607ArgArg: 2.607 ± 0.055	2.828ArgSer: 2.828 ± 0.041	2.154ArgThr: 2.154 ± 0.038	2.779ArgVal: 2.779 ± 0.041	0.745ArgTrp: 0.745 ± 0.022	1.836ArgTyr: 1.836 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	3.495SerAla: 3.495 ± 0.05	0.648SerCys: 0.648 ± 0.023	3.268SerAsp: 3.268 ± 0.049	3.778SerGlu: 3.778 ± 0.05	2.801SerPhe: 2.801 ± 0.045	4.172SerGly: 4.172 ± 0.064	1.506SerHis: 1.506 ± 0.034	4.256SerIle: 4.256 ± 0.055	2.85SerLys: 2.85 ± 0.043	8.081SerLeu: 8.081 ± 0.08	1.321SerMet: 1.321 ± 0.027	3.046SerAsn: 3.046 ± 0.057	3.471SerPro: 3.471 ± 0.053	3.913SerGln: 3.913 ± 0.061	2.892SerArg: 2.892 ± 0.052	4.557SerSer: 4.557 ± 0.068	3.099SerThr: 3.099 ± 0.047	3.692SerVal: 3.692 ± 0.045	0.907SerTrp: 0.907 ± 0.024	2.028SerTyr: 2.028 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	4.133ThrAla: 4.133 ± 0.065	0.463ThrCys: 0.463 ± 0.019	2.644ThrAsp: 2.644 ± 0.056	3.748ThrGlu: 3.748 ± 0.053	2.345ThrPhe: 2.345 ± 0.056	4.114ThrGly: 4.114 ± 0.07	1.104ThrHis: 1.104 ± 0.028	4.74ThrIle: 4.74 ± 0.065	2.502ThrLys: 2.502 ± 0.048	6.933ThrLeu: 6.933 ± 0.076	0.926ThrMet: 0.926 ± 0.027	2.379ThrAsn: 2.379 ± 0.04	3.323ThrPro: 3.323 ± 0.057	2.854ThrGln: 2.854 ± 0.046	2.157ThrArg: 2.157 ± 0.04	3.293ThrSer: 3.293 ± 0.049	3.3ThrThr: 3.3 ± 0.054	4.134ThrVal: 4.134 ± 0.06	0.735ThrTrp: 0.735 ± 0.02	1.831ThrTyr: 1.831 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	4.681ValAla: 4.681 ± 0.067	0.661ValCys: 0.661 ± 0.022	3.227ValAsp: 3.227 ± 0.056	4.106ValGlu: 4.106 ± 0.06	2.465ValPhe: 2.465 ± 0.043	4.147ValGly: 4.147 ± 0.056	0.916ValHis: 0.916 ± 0.026	4.757ValIle: 4.757 ± 0.059	3.542ValLys: 3.542 ± 0.052	5.788ValLeu: 5.788 ± 0.068	1.409ValMet: 1.409 ± 0.032	3.096ValAsn: 3.096 ± 0.043	2.631ValPro: 2.631 ± 0.044	2.216ValGln: 2.216 ± 0.04	2.597ValArg: 2.597 ± 0.043	4.215ValSer: 4.215 ± 0.048	3.808ValThr: 3.808 ± 0.053	3.966ValVal: 3.966 ± 0.055	0.776ValTrp: 0.776 ± 0.024	1.827ValTyr: 1.827 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.695TrpAla: 0.695 ± 0.022	0.165TrpCys: 0.165 ± 0.01	0.713TrpAsp: 0.713 ± 0.024	0.928TrpGlu: 0.928 ± 0.025	0.658TrpPhe: 0.658 ± 0.021	0.989TrpGly: 0.989 ± 0.028	0.33TrpHis: 0.33 ± 0.014	0.996TrpIle: 0.996 ± 0.028	0.77TrpLys: 0.77 ± 0.023	1.952TrpLeu: 1.952 ± 0.038	0.294TrpMet: 0.294 ± 0.013	0.631TrpAsn: 0.631 ± 0.021	0.29TrpPro: 0.29 ± 0.016	1.066TrpGln: 1.066 ± 0.029	0.703TrpArg: 0.703 ± 0.019	0.821TrpSer: 0.821 ± 0.026	0.648TrpThr: 0.648 ± 0.019	0.909TrpVal: 0.909 ± 0.023	0.228TrpTrp: 0.228 ± 0.014	0.449TrpTyr: 0.449 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.737TyrAla: 1.737 ± 0.038	0.474TyrCys: 0.474 ± 0.014	1.745TyrAsp: 1.745 ± 0.037	1.989TyrGlu: 1.989 ± 0.039	1.541TyrPhe: 1.541 ± 0.031	2.204TyrGly: 2.204 ± 0.037	0.876TyrHis: 0.876 ± 0.026	1.866TyrIle: 1.866 ± 0.03	1.375TyrLys: 1.375 ± 0.029	4.048TyrLeu: 4.048 ± 0.062	0.436TyrMet: 0.436 ± 0.017	1.396TyrAsn: 1.396 ± 0.032	1.783TyrPro: 1.783 ± 0.037	2.39TyrGln: 2.39 ± 0.043	1.914TyrArg: 1.914 ± 0.04	2.074TyrSer: 2.074 ± 0.036	1.541TyrThr: 1.541 ± 0.029	1.584TyrVal: 1.584 ± 0.031	0.592TyrTrp: 0.592 ± 0.02	1.317TyrTyr: 1.317 ± 0.031	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5239 proteins (1562895 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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