Amino acid dipepetide frequency for Xenococcus sp. PCC 7305

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.307AlaAla: 6.307 ± 0.083
0.735AlaCys: 0.735 ± 0.022
3.982AlaAsp: 3.982 ± 0.055
5.166AlaGlu: 5.166 ± 0.063
2.802AlaPhe: 2.802 ± 0.046
5.171AlaGly: 5.171 ± 0.079
1.164AlaHis: 1.164 ± 0.029
7.387AlaIle: 7.387 ± 0.087
4.289AlaLys: 4.289 ± 0.061
7.499AlaLeu: 7.499 ± 0.082
1.47AlaMet: 1.47 ± 0.039
3.747AlaAsn: 3.747 ± 0.068
2.502AlaPro: 2.502 ± 0.055
4.011AlaGln: 4.011 ± 0.05
3.102AlaArg: 3.102 ± 0.05
4.517AlaSer: 4.517 ± 0.066
4.514AlaThr: 4.514 ± 0.069
4.746AlaVal: 4.746 ± 0.056
0.904AlaTrp: 0.904 ± 0.024
2.193AlaTyr: 2.193 ± 0.041
0.0AlaXaa: 0.0 ± 0.0
Cys
0.54CysAla: 0.54 ± 0.021
0.147CysCys: 0.147 ± 0.009
0.638CysAsp: 0.638 ± 0.021
0.465CysGlu: 0.465 ± 0.019
0.445CysPhe: 0.445 ± 0.017
0.668CysGly: 0.668 ± 0.023
0.261CysHis: 0.261 ± 0.015
0.514CysIle: 0.514 ± 0.021
0.325CysLys: 0.325 ± 0.015
1.171CysLeu: 1.171 ± 0.03
0.156CysMet: 0.156 ± 0.009
0.393CysAsn: 0.393 ± 0.014
0.513CysPro: 0.513 ± 0.018
0.584CysGln: 0.584 ± 0.02
0.477CysArg: 0.477 ± 0.017
0.645CysSer: 0.645 ± 0.021
0.367CysThr: 0.367 ± 0.016
0.448CysVal: 0.448 ± 0.018
0.156CysTrp: 0.156 ± 0.011
0.369CysTyr: 0.369 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
3.504AspAla: 3.504 ± 0.053
0.535AspCys: 0.535 ± 0.018
2.89AspAsp: 2.89 ± 0.072
3.057AspGlu: 3.057 ± 0.05
2.879AspPhe: 2.879 ± 0.047
3.824AspGly: 3.824 ± 0.085
0.815AspHis: 0.815 ± 0.022
4.145AspIle: 4.145 ± 0.056
2.613AspLys: 2.613 ± 0.049
6.548AspLeu: 6.548 ± 0.08
0.727AspMet: 0.727 ± 0.021
2.953AspAsn: 2.953 ± 0.059
2.464AspPro: 2.464 ± 0.049
1.949AspGln: 1.949 ± 0.037
3.456AspArg: 3.456 ± 0.052
3.65AspSer: 3.65 ± 0.067
2.64AspThr: 2.64 ± 0.058
2.926AspVal: 2.926 ± 0.048
0.935AspTrp: 0.935 ± 0.025
2.265AspTyr: 2.265 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
5.146GluAla: 5.146 ± 0.074
0.442GluCys: 0.442 ± 0.019
3.315GluAsp: 3.315 ± 0.056
4.622GluGlu: 4.622 ± 0.073
2.575GluPhe: 2.575 ± 0.041
3.467GluGly: 3.467 ± 0.057
1.017GluHis: 1.017 ± 0.026
5.639GluIle: 5.639 ± 0.066
4.003GluLys: 4.003 ± 0.061
7.379GluLeu: 7.379 ± 0.08
1.214GluMet: 1.214 ± 0.032
3.269GluAsn: 3.269 ± 0.05
2.306GluPro: 2.306 ± 0.038
3.828GluGln: 3.828 ± 0.063
2.768GluArg: 2.768 ± 0.052
3.934GluSer: 3.934 ± 0.053
3.763GluThr: 3.763 ± 0.05
4.083GluVal: 4.083 ± 0.052
0.701GluTrp: 0.701 ± 0.021
2.027GluTyr: 2.027 ± 0.032
0.0GluXaa: 0.0 ± 0.0
Phe
3.336PheAla: 3.336 ± 0.054
0.539PheCys: 0.539 ± 0.018
2.572PheAsp: 2.572 ± 0.042
2.296PheGlu: 2.296 ± 0.041
1.987PhePhe: 1.987 ± 0.036
3.085PheGly: 3.085 ± 0.055
0.703PheHis: 0.703 ± 0.022
2.674PheIle: 2.674 ± 0.043
1.766PheLys: 1.766 ± 0.033
4.343PheLeu: 4.343 ± 0.063
0.656PheMet: 0.656 ± 0.023
1.992PheAsn: 1.992 ± 0.034
1.901PhePro: 1.901 ± 0.036
1.769PheGln: 1.769 ± 0.038
1.857PheArg: 1.857 ± 0.035
3.26PheSer: 3.26 ± 0.054
2.301PheThr: 2.301 ± 0.044
2.506PheVal: 2.506 ± 0.038
0.672PheTrp: 0.672 ± 0.022
1.397PheTyr: 1.397 ± 0.03
0.0PheXaa: 0.0 ± 0.0
Gly
4.769GlyAla: 4.769 ± 0.077
0.715GlyCys: 0.715 ± 0.022
4.086GlyAsp: 4.086 ± 0.081
4.22GlyGlu: 4.22 ± 0.067
3.124GlyPhe: 3.124 ± 0.05
4.854GlyGly: 4.854 ± 0.087
1.17GlyHis: 1.17 ± 0.034
5.347GlyIle: 5.347 ± 0.064
4.118GlyLys: 4.118 ± 0.056
6.639GlyLeu: 6.639 ± 0.084
1.377GlyMet: 1.377 ± 0.038
3.764GlyAsn: 3.764 ± 0.096
1.041GlyPro: 1.041 ± 0.03
2.872GlyGln: 2.872 ± 0.05
2.728GlyArg: 2.728 ± 0.044
4.261GlySer: 4.261 ± 0.065
3.84GlyThr: 3.84 ± 0.075
4.264GlyVal: 4.264 ± 0.059
1.003GlyTrp: 1.003 ± 0.026
2.333GlyTyr: 2.333 ± 0.036
0.0GlyXaa: 0.0 ± 0.0
His
0.891HisAla: 0.891 ± 0.023
0.235HisCys: 0.235 ± 0.013
0.816HisAsp: 0.816 ± 0.023
0.829HisGlu: 0.829 ± 0.028
0.75HisPhe: 0.75 ± 0.022
1.093HisGly: 1.093 ± 0.03
0.581HisHis: 0.581 ± 0.022
1.039HisIle: 1.039 ± 0.025
0.799HisLys: 0.799 ± 0.026
2.049HisLeu: 2.049 ± 0.039
0.244HisMet: 0.244 ± 0.012
0.866HisAsn: 0.866 ± 0.023
1.058HisPro: 1.058 ± 0.027
1.117HisGln: 1.117 ± 0.03
0.909HisArg: 0.909 ± 0.024
1.144HisSer: 1.144 ± 0.026
0.702HisThr: 0.702 ± 0.022
0.711HisVal: 0.711 ± 0.024
0.306HisTrp: 0.306 ± 0.014
0.679HisTyr: 0.679 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
7.806IleAla: 7.806 ± 0.085
0.783IleCys: 0.783 ± 0.025
4.464IleAsp: 4.464 ± 0.069
5.112IleGlu: 5.112 ± 0.057
3.084IlePhe: 3.084 ± 0.05
4.712IleGly: 4.712 ± 0.062
1.107IleHis: 1.107 ± 0.023
5.163IleIle: 5.163 ± 0.067
3.788IleLys: 3.788 ± 0.054
7.336IleLeu: 7.336 ± 0.075
1.075IleMet: 1.075 ± 0.025
3.757IleAsn: 3.757 ± 0.065
3.816IlePro: 3.816 ± 0.057
2.784IleGln: 2.784 ± 0.042
3.139IleArg: 3.139 ± 0.051
5.268IleSer: 5.268 ± 0.055
4.42IleThr: 4.42 ± 0.071
4.724IleVal: 4.724 ± 0.061
0.893IleTrp: 0.893 ± 0.024
2.213IleTyr: 2.213 ± 0.04
0.0IleXaa: 0.0 ± 0.0
Lys
4.004LysAla: 4.004 ± 0.06
0.314LysCys: 0.314 ± 0.015
2.475LysAsp: 2.475 ± 0.046
3.278LysGlu: 3.278 ± 0.066
2.081LysPhe: 2.081 ± 0.043
2.685LysGly: 2.685 ± 0.045
0.821LysHis: 0.821 ± 0.026
4.715LysIle: 4.715 ± 0.058
3.288LysLys: 3.288 ± 0.05
5.969LysLeu: 5.969 ± 0.069
1.049LysMet: 1.049 ± 0.029
2.65LysAsn: 2.65 ± 0.049
2.338LysPro: 2.338 ± 0.041
2.739LysGln: 2.739 ± 0.049
2.304LysArg: 2.304 ± 0.046
3.317LysSer: 3.317 ± 0.054
3.239LysThr: 3.239 ± 0.05
3.311LysVal: 3.311 ± 0.046
0.521LysTrp: 0.521 ± 0.018
1.792LysTyr: 1.792 ± 0.033
0.0LysXaa: 0.0 ± 0.0
Leu
9.218LeuAla: 9.218 ± 0.094
0.935LeuCys: 0.935 ± 0.025
6.048LeuAsp: 6.048 ± 0.064
7.827LeuGlu: 7.827 ± 0.091
3.994LeuPhe: 3.994 ± 0.053
7.533LeuGly: 7.533 ± 0.073
1.614LeuHis: 1.614 ± 0.033
7.355LeuIle: 7.355 ± 0.076
5.777LeuLys: 5.777 ± 0.075
10.586LeuLeu: 10.586 ± 0.11
1.911LeuMet: 1.911 ± 0.043
5.026LeuAsn: 5.026 ± 0.069
4.99LeuPro: 4.99 ± 0.067
5.089LeuGln: 5.089 ± 0.068
4.776LeuArg: 4.776 ± 0.062
7.611LeuSer: 7.611 ± 0.082
6.279LeuThr: 6.279 ± 0.062
6.947LeuVal: 6.947 ± 0.073
1.331LeuTrp: 1.331 ± 0.032
2.789LeuTyr: 2.789 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
1.539MetAla: 1.539 ± 0.037
0.087MetCys: 0.087 ± 0.007
0.706MetAsp: 0.706 ± 0.021
0.863MetGlu: 0.863 ± 0.027
0.604MetPhe: 0.604 ± 0.021
1.313MetGly: 1.313 ± 0.036
0.239MetHis: 0.239 ± 0.012
1.193MetIle: 1.193 ± 0.031
1.061MetLys: 1.061 ± 0.029
1.722MetLeu: 1.722 ± 0.037
0.431MetMet: 0.431 ± 0.018
0.891MetAsn: 0.891 ± 0.022
0.792MetPro: 0.792 ± 0.025
0.696MetGln: 0.696 ± 0.019
0.824MetArg: 0.824 ± 0.023
1.417MetSer: 1.417 ± 0.027
1.212MetThr: 1.212 ± 0.029
1.132MetVal: 1.132 ± 0.028
0.117MetTrp: 0.117 ± 0.008
0.351MetTyr: 0.351 ± 0.014
0.0MetXaa: 0.0 ± 0.0
Asn
3.068AsnAla: 3.068 ± 0.058
0.521AsnCys: 0.521 ± 0.02
2.467AsnAsp: 2.467 ± 0.077
2.079AsnGlu: 2.079 ± 0.038
2.36AsnPhe: 2.36 ± 0.041
3.143AsnGly: 3.143 ± 0.095
0.96AsnHis: 0.96 ± 0.028
3.814AsnIle: 3.814 ± 0.074
2.291AsnLys: 2.291 ± 0.041
6.441AsnLeu: 6.441 ± 0.079
0.763AsnMet: 0.763 ± 0.022
3.09AsnAsn: 3.09 ± 0.074
2.982AsnPro: 2.982 ± 0.049
2.863AsnGln: 2.863 ± 0.05
2.305AsnArg: 2.305 ± 0.038
3.919AsnSer: 3.919 ± 0.062
2.332AsnThr: 2.332 ± 0.055
2.296AsnVal: 2.296 ± 0.047
0.785AsnTrp: 0.785 ± 0.024
1.81AsnTyr: 1.81 ± 0.036
0.0AsnXaa: 0.0 ± 0.0
Pro
2.487ProAla: 2.487 ± 0.042
0.317ProCys: 0.317 ± 0.015
2.716ProAsp: 2.716 ± 0.056
3.945ProGlu: 3.945 ± 0.056
1.639ProPhe: 1.639 ± 0.028
2.806ProGly: 2.806 ± 0.045
0.787ProHis: 0.787 ± 0.024
3.015ProIle: 3.015 ± 0.049
2.092ProLys: 2.092 ± 0.04
4.182ProLeu: 4.182 ± 0.053
0.659ProMet: 0.659 ± 0.019
2.268ProAsn: 2.268 ± 0.045
1.684ProPro: 1.684 ± 0.04
2.502ProGln: 2.502 ± 0.047
1.572ProArg: 1.572 ± 0.036
2.504ProSer: 2.504 ± 0.045
2.358ProThr: 2.358 ± 0.046
2.625ProVal: 2.625 ± 0.043
0.556ProTrp: 0.556 ± 0.021
1.248ProTyr: 1.248 ± 0.026
0.0ProXaa: 0.0 ± 0.0
Gln
4.145GlnAla: 4.145 ± 0.072
0.315GlnCys: 0.315 ± 0.015
2.677GlnAsp: 2.677 ± 0.038
4.259GlnGlu: 4.259 ± 0.066
1.599GlnPhe: 1.599 ± 0.033
3.298GlnGly: 3.298 ± 0.047
0.715GlnHis: 0.715 ± 0.019
3.798GlnIle: 3.798 ± 0.05
3.199GlnLys: 3.199 ± 0.054
5.328GlnLeu: 5.328 ± 0.068
0.886GlnMet: 0.886 ± 0.022
2.403GlnAsn: 2.403 ± 0.042
1.959GlnPro: 1.959 ± 0.041
3.191GlnGln: 3.191 ± 0.065
2.17GlnArg: 2.17 ± 0.04
2.818GlnSer: 2.818 ± 0.044
2.683GlnThr: 2.683 ± 0.047
3.191GlnVal: 3.191 ± 0.049
0.669GlnTrp: 0.669 ± 0.019
1.246GlnTyr: 1.246 ± 0.028
0.001GlnXaa: 0.001 ± 0.001
Arg
2.83ArgAla: 2.83 ± 0.048
0.402ArgCys: 0.402 ± 0.018
2.587ArgAsp: 2.587 ± 0.04
3.124ArgGlu: 3.124 ± 0.046
2.045ArgPhe: 2.045 ± 0.032
2.681ArgGly: 2.681 ± 0.043
0.814ArgHis: 0.814 ± 0.028
3.221ArgIle: 3.221 ± 0.051
2.523ArgLys: 2.523 ± 0.048
5.01ArgLeu: 5.01 ± 0.061
0.797ArgMet: 0.797 ± 0.024
2.183ArgAsn: 2.183 ± 0.037
1.672ArgPro: 1.672 ± 0.04
2.641ArgGln: 2.641 ± 0.047
2.447ArgArg: 2.447 ± 0.045
3.05ArgSer: 3.05 ± 0.044
2.1ArgThr: 2.1 ± 0.034
2.744ArgVal: 2.744 ± 0.046
0.635ArgTrp: 0.635 ± 0.02
1.674ArgTyr: 1.674 ± 0.029
0.0ArgXaa: 0.0 ± 0.0
Ser
4.348SerAla: 4.348 ± 0.053
0.695SerCys: 0.695 ± 0.022
3.743SerAsp: 3.743 ± 0.063
4.042SerGlu: 4.042 ± 0.053
3.003SerPhe: 3.003 ± 0.047
4.823SerGly: 4.823 ± 0.076
1.261SerHis: 1.261 ± 0.029
4.419SerIle: 4.419 ± 0.058
3.024SerLys: 3.024 ± 0.045
8.088SerLeu: 8.088 ± 0.089
1.096SerMet: 1.096 ± 0.028
3.376SerAsn: 3.376 ± 0.068
3.027SerPro: 3.027 ± 0.049
3.812SerGln: 3.812 ± 0.054
3.018SerArg: 3.018 ± 0.045
5.035SerSer: 5.035 ± 0.072
3.306SerThr: 3.306 ± 0.054
3.801SerVal: 3.801 ± 0.057
1.023SerTrp: 1.023 ± 0.028
2.171SerTyr: 2.171 ± 0.043
0.0SerXaa: 0.0 ± 0.0
Thr
4.379ThrAla: 4.379 ± 0.063
0.458ThrCys: 0.458 ± 0.018
2.775ThrAsp: 2.775 ± 0.062
3.536ThrGlu: 3.536 ± 0.048
2.046ThrPhe: 2.046 ± 0.044
4.197ThrGly: 4.197 ± 0.067
0.874ThrHis: 0.874 ± 0.022
4.721ThrIle: 4.721 ± 0.071
2.788ThrLys: 2.788 ± 0.045
5.703ThrLeu: 5.703 ± 0.066
0.796ThrMet: 0.796 ± 0.022
2.693ThrAsn: 2.693 ± 0.055
2.706ThrPro: 2.706 ± 0.043
2.37ThrGln: 2.37 ± 0.043
2.16ThrArg: 2.16 ± 0.038
3.516ThrSer: 3.516 ± 0.055
3.367ThrThr: 3.367 ± 0.07
3.853ThrVal: 3.853 ± 0.058
0.694ThrTrp: 0.694 ± 0.024
1.641ThrTyr: 1.641 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
5.259ValAla: 5.259 ± 0.063
0.562ValCys: 0.562 ± 0.02
3.439ValAsp: 3.439 ± 0.055
4.161ValGlu: 4.161 ± 0.053
2.537ValPhe: 2.537 ± 0.047
4.207ValGly: 4.207 ± 0.059
0.896ValHis: 0.896 ± 0.027
4.597ValIle: 4.597 ± 0.05
3.221ValLys: 3.221 ± 0.049
5.821ValLeu: 5.821 ± 0.062
1.198ValMet: 1.198 ± 0.029
2.991ValAsn: 2.991 ± 0.051
2.421ValPro: 2.421 ± 0.035
2.206ValGln: 2.206 ± 0.043
2.581ValArg: 2.581 ± 0.042
4.177ValSer: 4.177 ± 0.055
3.888ValThr: 3.888 ± 0.058
4.105ValVal: 4.105 ± 0.048
0.726ValTrp: 0.726 ± 0.025
1.746ValTyr: 1.746 ± 0.038
0.0ValXaa: 0.0 ± 0.0
Trp
0.774TrpAla: 0.774 ± 0.023
0.14TrpCys: 0.14 ± 0.008
0.659TrpAsp: 0.659 ± 0.02
0.829TrpGlu: 0.829 ± 0.024
0.59TrpPhe: 0.59 ± 0.02
0.898TrpGly: 0.898 ± 0.024
0.334TrpHis: 0.334 ± 0.013
0.834TrpIle: 0.834 ± 0.024
0.58TrpLys: 0.58 ± 0.019
1.804TrpLeu: 1.804 ± 0.036
0.268TrpMet: 0.268 ± 0.013
0.609TrpAsn: 0.609 ± 0.023
0.235TrpPro: 0.235 ± 0.013
1.293TrpGln: 1.293 ± 0.034
0.701TrpArg: 0.701 ± 0.021
0.93TrpSer: 0.93 ± 0.027
0.558TrpThr: 0.558 ± 0.022
0.741TrpVal: 0.741 ± 0.023
0.213TrpTrp: 0.213 ± 0.013
0.403TrpTyr: 0.403 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.862TyrAla: 1.862 ± 0.032
0.401TyrCys: 0.401 ± 0.016
1.719TyrAsp: 1.719 ± 0.039
1.788TyrGlu: 1.788 ± 0.038
1.469TyrPhe: 1.469 ± 0.028
2.067TyrGly: 2.067 ± 0.043
0.685TyrHis: 0.685 ± 0.019
1.854TyrIle: 1.854 ± 0.032
1.347TyrLys: 1.347 ± 0.035
4.014TyrLeu: 4.014 ± 0.058
0.421TyrMet: 0.421 ± 0.015
1.368TyrAsn: 1.368 ± 0.032
1.552TyrPro: 1.552 ± 0.033
2.232TyrGln: 2.232 ± 0.039
1.888TyrArg: 1.888 ± 0.037
2.135TyrSer: 2.135 ± 0.039
1.402TyrThr: 1.402 ± 0.031
1.586TyrVal: 1.586 ± 0.03
0.555TyrTrp: 0.555 ± 0.018
1.277TyrTyr: 1.277 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.001XaaGlu: 0.001 ± 0.001
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5347 proteins (1695650 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski