Amino acid dipepetide frequency for Rippkaea orientalis (strain PCC 8801) (Cyanothece sp. (strain PCC 8801))

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.373AlaAla: 5.373 ± 0.083	0.724AlaCys: 0.724 ± 0.026	3.219AlaAsp: 3.219 ± 0.063	4.332AlaGlu: 4.332 ± 0.062	2.636AlaPhe: 2.636 ± 0.049	4.237AlaGly: 4.237 ± 0.072	1.119AlaHis: 1.119 ± 0.028	6.545AlaIle: 6.545 ± 0.089	4.204AlaLys: 4.204 ± 0.066	7.63AlaLeu: 7.63 ± 0.093	1.559AlaMet: 1.559 ± 0.037	3.032AlaAsn: 3.032 ± 0.067	2.247AlaPro: 2.247 ± 0.047	3.908AlaGln: 3.908 ± 0.066	2.758AlaArg: 2.758 ± 0.055	4.028AlaSer: 4.028 ± 0.062	3.952AlaThr: 3.952 ± 0.061	4.344AlaVal: 4.344 ± 0.06	0.895AlaTrp: 0.895 ± 0.027	2.206AlaTyr: 2.206 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	0.539CysAla: 0.539 ± 0.02	0.179CysCys: 0.179 ± 0.011	0.555CysAsp: 0.555 ± 0.02	0.493CysGlu: 0.493 ± 0.022	0.439CysPhe: 0.439 ± 0.021	0.8CysGly: 0.8 ± 0.029	0.327CysHis: 0.327 ± 0.017	0.563CysIle: 0.563 ± 0.021	0.287CysLys: 0.287 ± 0.014	1.355CysLeu: 1.355 ± 0.037	0.135CysMet: 0.135 ± 0.011	0.38CysAsn: 0.38 ± 0.017	0.619CysPro: 0.619 ± 0.023	0.806CysGln: 0.806 ± 0.027	0.522CysArg: 0.522 ± 0.023	0.663CysSer: 0.663 ± 0.022	0.443CysThr: 0.443 ± 0.016	0.554CysVal: 0.554 ± 0.023	0.156CysTrp: 0.156 ± 0.011	0.425CysTyr: 0.425 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	2.915AspAla: 2.915 ± 0.044	0.599AspCys: 0.599 ± 0.023	2.151AspAsp: 2.151 ± 0.049	2.932AspGlu: 2.932 ± 0.063	2.279AspPhe: 2.279 ± 0.043	3.084AspGly: 3.084 ± 0.059	1.042AspHis: 1.042 ± 0.029	3.55AspIle: 3.55 ± 0.066	2.423AspLys: 2.423 ± 0.046	5.952AspLeu: 5.952 ± 0.083	0.734AspMet: 0.734 ± 0.021	2.341AspAsn: 2.341 ± 0.049	2.683AspPro: 2.683 ± 0.046	2.297AspGln: 2.297 ± 0.048	2.891AspArg: 2.891 ± 0.046	2.879AspSer: 2.879 ± 0.053	2.315AspThr: 2.315 ± 0.042	2.673AspVal: 2.673 ± 0.05	0.886AspTrp: 0.886 ± 0.026	2.214AspTyr: 2.214 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.138GluAla: 5.138 ± 0.07	0.444GluCys: 0.444 ± 0.019	2.995GluAsp: 2.995 ± 0.051	4.687GluGlu: 4.687 ± 0.064	2.304GluPhe: 2.304 ± 0.046	3.531GluGly: 3.531 ± 0.06	1.004GluHis: 1.004 ± 0.035	5.564GluIle: 5.564 ± 0.082	4.217GluLys: 4.217 ± 0.066	7.088GluLeu: 7.088 ± 0.086	1.404GluMet: 1.404 ± 0.03	3.008GluAsn: 3.008 ± 0.052	2.406GluPro: 2.406 ± 0.039	3.742GluGln: 3.742 ± 0.058	3.135GluArg: 3.135 ± 0.062	3.545GluSer: 3.545 ± 0.051	4.214GluThr: 4.214 ± 0.063	4.228GluVal: 4.228 ± 0.059	0.803GluTrp: 0.803 ± 0.027	1.847GluTyr: 1.847 ± 0.039	0.0GluXaa: 0.0 ± 0.0
Phe	2.575PheAla: 2.575 ± 0.04	0.576PheCys: 0.576 ± 0.022	2.263PheAsp: 2.263 ± 0.036	2.408PheGlu: 2.408 ± 0.044	1.756PhePhe: 1.756 ± 0.051	2.625PheGly: 2.625 ± 0.053	0.719PheHis: 0.719 ± 0.023	2.656PheIle: 2.656 ± 0.053	1.893PheLys: 1.893 ± 0.043	4.35PheLeu: 4.35 ± 0.069	0.72PheMet: 0.72 ± 0.023	1.967PheAsn: 1.967 ± 0.043	2.031PhePro: 2.031 ± 0.042	1.719PheGln: 1.719 ± 0.041	1.823PheArg: 1.823 ± 0.04	3.096PheSer: 3.096 ± 0.052	2.128PheThr: 2.128 ± 0.043	2.357PheVal: 2.357 ± 0.049	0.756PheTrp: 0.756 ± 0.028	1.498PheTyr: 1.498 ± 0.039	0.0PheXaa: 0.0 ± 0.0
Gly	3.904GlyAla: 3.904 ± 0.082	0.786GlyCys: 0.786 ± 0.026	3.15GlyAsp: 3.15 ± 0.06	4.096GlyGlu: 4.096 ± 0.054	2.944GlyPhe: 2.944 ± 0.05	4.582GlyGly: 4.582 ± 0.081	1.244GlyHis: 1.244 ± 0.029	5.442GlyIle: 5.442 ± 0.072	4.004GlyLys: 4.004 ± 0.066	7.155GlyLeu: 7.155 ± 0.1	1.44GlyMet: 1.44 ± 0.034	2.881GlyAsn: 2.881 ± 0.062	1.184GlyPro: 1.184 ± 0.034	3.199GlyGln: 3.199 ± 0.059	2.924GlyArg: 2.924 ± 0.053	3.782GlySer: 3.782 ± 0.054	3.879GlyThr: 3.879 ± 0.071	4.454GlyVal: 4.454 ± 0.061	1.108GlyTrp: 1.108 ± 0.031	2.467GlyTyr: 2.467 ± 0.038	0.0GlyXaa: 0.0 ± 0.0
His	0.93HisAla: 0.93 ± 0.027	0.306HisCys: 0.306 ± 0.016	0.775HisAsp: 0.775 ± 0.026	0.918HisGlu: 0.918 ± 0.026	0.876HisPhe: 0.876 ± 0.031	1.136HisGly: 1.136 ± 0.031	0.708HisHis: 0.708 ± 0.032	1.064HisIle: 1.064 ± 0.033	0.769HisLys: 0.769 ± 0.024	2.402HisLeu: 2.402 ± 0.051	0.183HisMet: 0.183 ± 0.011	0.827HisAsn: 0.827 ± 0.024	1.472HisPro: 1.472 ± 0.037	1.461HisGln: 1.461 ± 0.035	1.129HisArg: 1.129 ± 0.03	1.136HisSer: 1.136 ± 0.029	0.803HisThr: 0.803 ± 0.026	0.681HisVal: 0.681 ± 0.024	0.381HisTrp: 0.381 ± 0.018	0.812HisTyr: 0.812 ± 0.021	0.0HisXaa: 0.0 ± 0.0
Ile	6.735IleAla: 6.735 ± 0.089	0.767IleCys: 0.767 ± 0.026	4.091IleAsp: 4.091 ± 0.056	5.009IleGlu: 5.009 ± 0.073	2.899IlePhe: 2.899 ± 0.053	4.552IleGly: 4.552 ± 0.073	1.297IleHis: 1.297 ± 0.033	5.297IleIle: 5.297 ± 0.081	3.823IleLys: 3.823 ± 0.06	7.952IleLeu: 7.952 ± 0.093	1.101IleMet: 1.101 ± 0.033	3.841IleAsn: 3.841 ± 0.067	4.05IlePro: 4.05 ± 0.061	3.063IleGln: 3.063 ± 0.058	3.192IleArg: 3.192 ± 0.057	4.63IleSer: 4.63 ± 0.064	4.21IleThr: 4.21 ± 0.052	4.305IleVal: 4.305 ± 0.06	0.888IleTrp: 0.888 ± 0.026	2.28IleTyr: 2.28 ± 0.044	0.0IleXaa: 0.0 ± 0.0
Lys	4.065LysAla: 4.065 ± 0.068	0.357LysCys: 0.357 ± 0.018	2.519LysAsp: 2.519 ± 0.064	3.4LysGlu: 3.4 ± 0.055	1.734LysPhe: 1.734 ± 0.041	2.995LysGly: 2.995 ± 0.048	0.779LysHis: 0.779 ± 0.024	4.341LysIle: 4.341 ± 0.074	2.936LysLys: 2.936 ± 0.05	5.76LysLeu: 5.76 ± 0.083	1.09LysMet: 1.09 ± 0.028	2.603LysAsn: 2.603 ± 0.042	2.485LysPro: 2.485 ± 0.045	3.14LysGln: 3.14 ± 0.052	2.56LysArg: 2.56 ± 0.045	3.209LysSer: 3.209 ± 0.048	3.507LysThr: 3.507 ± 0.057	3.314LysVal: 3.314 ± 0.055	0.528LysTrp: 0.528 ± 0.019	1.509LysTyr: 1.509 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	8.676LeuAla: 8.676 ± 0.089	1.073LeuCys: 1.073 ± 0.028	5.723LeuAsp: 5.723 ± 0.079	8.264LeuGlu: 8.264 ± 0.083	4.005LeuPhe: 4.005 ± 0.07	8.05LeuGly: 8.05 ± 0.077	1.715LeuHis: 1.715 ± 0.033	8.099LeuIle: 8.099 ± 0.096	6.574LeuLys: 6.574 ± 0.083	11.462LeuLeu: 11.462 ± 0.128	2.358LeuMet: 2.358 ± 0.04	5.02LeuAsn: 5.02 ± 0.066	5.473LeuPro: 5.473 ± 0.074	5.21LeuGln: 5.21 ± 0.07	5.066LeuArg: 5.066 ± 0.075	8.13LeuSer: 8.13 ± 0.088	7.17LeuThr: 7.17 ± 0.083	6.968LeuVal: 6.968 ± 0.081	1.435LeuTrp: 1.435 ± 0.039	2.892LeuTyr: 2.892 ± 0.058	0.0LeuXaa: 0.0 ± 0.0
Met	1.705MetAla: 1.705 ± 0.038	0.12MetCys: 0.12 ± 0.009	0.769MetAsp: 0.769 ± 0.023	1.008MetGlu: 1.008 ± 0.03	0.55MetPhe: 0.55 ± 0.019	1.508MetGly: 1.508 ± 0.04	0.209MetHis: 0.209 ± 0.013	1.477MetIle: 1.477 ± 0.033	1.112MetLys: 1.112 ± 0.031	1.84MetLeu: 1.84 ± 0.041	0.511MetMet: 0.511 ± 0.023	0.903MetAsn: 0.903 ± 0.026	0.828MetPro: 0.828 ± 0.028	0.672MetGln: 0.672 ± 0.022	0.844MetArg: 0.844 ± 0.028	1.375MetSer: 1.375 ± 0.032	1.501MetThr: 1.501 ± 0.037	1.372MetVal: 1.372 ± 0.035	0.13MetTrp: 0.13 ± 0.011	0.333MetTyr: 0.333 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.705AsnAla: 2.705 ± 0.05	0.578AsnCys: 0.578 ± 0.022	1.824AsnAsp: 1.824 ± 0.036	2.01AsnGlu: 2.01 ± 0.044	2.05AsnPhe: 2.05 ± 0.04	2.462AsnGly: 2.462 ± 0.062	1.113AsnHis: 1.113 ± 0.035	2.953AsnIle: 2.953 ± 0.055	2.051AsnLys: 2.051 ± 0.045	5.941AsnLeu: 5.941 ± 0.099	0.674AsnMet: 0.674 ± 0.024	2.575AsnAsn: 2.575 ± 0.06	3.156AsnPro: 3.156 ± 0.056	3.27AsnGln: 3.27 ± 0.056	2.423AsnArg: 2.423 ± 0.049	3.015AsnSer: 3.015 ± 0.058	2.366AsnThr: 2.366 ± 0.06	2.095AsnVal: 2.095 ± 0.045	0.834AsnTrp: 0.834 ± 0.027	1.899AsnTyr: 1.899 ± 0.042	0.0AsnXaa: 0.0 ± 0.0
Pro	2.294ProAla: 2.294 ± 0.041	0.398ProCys: 0.398 ± 0.016	3.01ProAsp: 3.01 ± 0.057	3.909ProGlu: 3.909 ± 0.064	1.898ProPhe: 1.898 ± 0.037	2.766ProGly: 2.766 ± 0.052	0.999ProHis: 0.999 ± 0.028	3.468ProIle: 3.468 ± 0.054	2.366ProLys: 2.366 ± 0.05	5.169ProLeu: 5.169 ± 0.07	0.775ProMet: 0.775 ± 0.024	2.506ProAsn: 2.506 ± 0.05	2.392ProPro: 2.392 ± 0.056	2.808ProGln: 2.808 ± 0.048	1.784ProArg: 1.784 ± 0.041	3.221ProSer: 3.221 ± 0.059	2.623ProThr: 2.623 ± 0.051	2.896ProVal: 2.896 ± 0.044	0.673ProTrp: 0.673 ± 0.023	1.492ProTyr: 1.492 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	4.175GlnAla: 4.175 ± 0.07	0.413GlnCys: 0.413 ± 0.018	2.354GlnAsp: 2.354 ± 0.042	4.444GlnGlu: 4.444 ± 0.07	2.008GlnPhe: 2.008 ± 0.037	3.911GlnGly: 3.911 ± 0.069	0.779GlnHis: 0.779 ± 0.026	3.695GlnIle: 3.695 ± 0.062	3.38GlnLys: 3.38 ± 0.067	6.393GlnLeu: 6.393 ± 0.085	1.059GlnMet: 1.059 ± 0.032	2.053GlnAsn: 2.053 ± 0.046	2.432GlnPro: 2.432 ± 0.046	3.802GlnGln: 3.802 ± 0.069	2.715GlnArg: 2.715 ± 0.057	3.028GlnSer: 3.028 ± 0.052	3.133GlnThr: 3.133 ± 0.054	3.576GlnVal: 3.576 ± 0.059	0.892GlnTrp: 0.892 ± 0.029	1.409GlnTyr: 1.409 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.477ArgAla: 2.477 ± 0.05	0.484ArgCys: 0.484 ± 0.021	2.34ArgAsp: 2.34 ± 0.046	3.218ArgGlu: 3.218 ± 0.056	2.134ArgPhe: 2.134 ± 0.042	2.849ArgGly: 2.849 ± 0.052	1.011ArgHis: 1.011 ± 0.03	3.193ArgIle: 3.193 ± 0.048	2.259ArgLys: 2.259 ± 0.045	5.805ArgLeu: 5.805 ± 0.07	0.92ArgMet: 0.92 ± 0.026	1.963ArgAsn: 1.963 ± 0.04	1.919ArgPro: 1.919 ± 0.046	3.171ArgGln: 3.171 ± 0.052	2.683ArgArg: 2.683 ± 0.065	2.942ArgSer: 2.942 ± 0.047	2.26ArgThr: 2.26 ± 0.042	2.916ArgVal: 2.916 ± 0.055	0.8ArgTrp: 0.8 ± 0.024	1.877ArgTyr: 1.877 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	3.519SerAla: 3.519 ± 0.057	0.667SerCys: 0.667 ± 0.023	3.194SerAsp: 3.194 ± 0.052	3.753SerGlu: 3.753 ± 0.047	2.623SerPhe: 2.623 ± 0.045	4.143SerGly: 4.143 ± 0.057	1.425SerHis: 1.425 ± 0.033	4.136SerIle: 4.136 ± 0.064	2.63SerLys: 2.63 ± 0.047	8.073SerLeu: 8.073 ± 0.072	1.221SerMet: 1.221 ± 0.033	2.807SerAsn: 2.807 ± 0.049	3.763SerPro: 3.763 ± 0.059	4.058SerGln: 4.058 ± 0.064	3.051SerArg: 3.051 ± 0.046	4.625SerSer: 4.625 ± 0.075	3.109SerThr: 3.109 ± 0.05	3.735SerVal: 3.735 ± 0.065	0.907SerTrp: 0.907 ± 0.028	2.023SerTyr: 2.023 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.073ThrAla: 4.073 ± 0.061	0.481ThrCys: 0.481 ± 0.022	2.598ThrAsp: 2.598 ± 0.046	3.556ThrGlu: 3.556 ± 0.052	2.161ThrPhe: 2.161 ± 0.046	4.059ThrGly: 4.059 ± 0.082	1.118ThrHis: 1.118 ± 0.029	4.348ThrIle: 4.348 ± 0.058	2.436ThrLys: 2.436 ± 0.052	6.942ThrLeu: 6.942 ± 0.08	0.869ThrMet: 0.869 ± 0.025	2.36ThrAsn: 2.36 ± 0.054	3.517ThrPro: 3.517 ± 0.057	3.075ThrGln: 3.075 ± 0.055	2.229ThrArg: 2.229 ± 0.045	3.233ThrSer: 3.233 ± 0.056	3.247ThrThr: 3.247 ± 0.065	3.974ThrVal: 3.974 ± 0.066	0.744ThrTrp: 0.744 ± 0.022	1.753ThrTyr: 1.753 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	4.656ValAla: 4.656 ± 0.069	0.654ValCys: 0.654 ± 0.024	3.071ValAsp: 3.071 ± 0.054	4.122ValGlu: 4.122 ± 0.054	2.485ValPhe: 2.485 ± 0.041	4.092ValGly: 4.092 ± 0.069	0.987ValHis: 0.987 ± 0.03	4.832ValIle: 4.832 ± 0.066	3.514ValLys: 3.514 ± 0.051	5.938ValLeu: 5.938 ± 0.074	1.334ValMet: 1.334 ± 0.032	2.956ValAsn: 2.956 ± 0.062	2.646ValPro: 2.646 ± 0.053	2.439ValGln: 2.439 ± 0.045	2.748ValArg: 2.748 ± 0.054	4.04ValSer: 4.04 ± 0.056	3.745ValThr: 3.745 ± 0.069	3.969ValVal: 3.969 ± 0.06	0.778ValTrp: 0.778 ± 0.028	1.866ValTyr: 1.866 ± 0.039	0.0ValXaa: 0.0 ± 0.0
Trp	0.68TrpAla: 0.68 ± 0.023	0.153TrpCys: 0.153 ± 0.01	0.639TrpAsp: 0.639 ± 0.02	0.934TrpGlu: 0.934 ± 0.028	0.634TrpPhe: 0.634 ± 0.019	1.082TrpGly: 1.082 ± 0.034	0.296TrpHis: 0.296 ± 0.016	0.941TrpIle: 0.941 ± 0.029	0.734TrpLys: 0.734 ± 0.027	2.017TrpLeu: 2.017 ± 0.043	0.289TrpMet: 0.289 ± 0.015	0.652TrpAsn: 0.652 ± 0.022	0.304TrpPro: 0.304 ± 0.014	1.218TrpGln: 1.218 ± 0.034	0.733TrpArg: 0.733 ± 0.024	0.827TrpSer: 0.827 ± 0.026	0.707TrpThr: 0.707 ± 0.024	0.929TrpVal: 0.929 ± 0.028	0.24TrpTrp: 0.24 ± 0.012	0.446TrpTyr: 0.446 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.816TyrAla: 1.816 ± 0.037	0.482TyrCys: 0.482 ± 0.021	1.6TyrAsp: 1.6 ± 0.047	1.81TyrGlu: 1.81 ± 0.039	1.502TyrPhe: 1.502 ± 0.038	2.159TyrGly: 2.159 ± 0.039	0.877TyrHis: 0.877 ± 0.027	1.818TyrIle: 1.818 ± 0.04	1.217TyrLys: 1.217 ± 0.036	4.136TyrLeu: 4.136 ± 0.056	0.389TyrMet: 0.389 ± 0.02	1.318TyrAsn: 1.318 ± 0.037	1.841TyrPro: 1.841 ± 0.045	2.597TyrGln: 2.597 ± 0.05	2.01TyrArg: 2.01 ± 0.044	2.056TyrSer: 2.056 ± 0.039	1.462TyrThr: 1.462 ± 0.035	1.534TyrVal: 1.534 ± 0.033	0.623TyrTrp: 0.623 ± 0.022	1.294TyrTyr: 1.294 ± 0.036	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4335 proteins (1335749 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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