Amino acid dipepetide frequency for Enterorhabdus caecimuris B7

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.121AlaAla: 20.121 ± 0.358
2.23AlaCys: 2.23 ± 0.081
7.989AlaAsp: 7.989 ± 0.195
8.768AlaGlu: 8.768 ± 0.123
4.445AlaPhe: 4.445 ± 0.102
10.892AlaGly: 10.892 ± 0.164
2.012AlaHis: 2.012 ± 0.06
5.425AlaIle: 5.425 ± 0.148
4.235AlaLys: 4.235 ± 0.085
12.484AlaLeu: 12.484 ± 0.286
3.273AlaMet: 3.273 ± 0.09
3.071AlaAsn: 3.071 ± 0.096
5.829AlaPro: 5.829 ± 0.129
3.554AlaGln: 3.554 ± 0.076
7.399AlaArg: 7.399 ± 0.168
7.073AlaSer: 7.073 ± 0.101
6.273AlaThr: 6.273 ± 0.143
10.169AlaVal: 10.169 ± 0.158
1.373AlaTrp: 1.373 ± 0.04
3.184AlaTyr: 3.184 ± 0.09
0.0AlaXaa: 0.0 ± 0.0
Cys
2.005CysAla: 2.005 ± 0.067
0.299CysCys: 0.299 ± 0.021
0.925CysAsp: 0.925 ± 0.035
0.942CysGlu: 0.942 ± 0.039
0.497CysPhe: 0.497 ± 0.025
1.681CysGly: 1.681 ± 0.056
0.311CysHis: 0.311 ± 0.027
0.676CysIle: 0.676 ± 0.027
0.45CysLys: 0.45 ± 0.026
1.248CysLeu: 1.248 ± 0.051
0.359CysMet: 0.359 ± 0.022
0.362CysAsn: 0.362 ± 0.026
0.889CysPro: 0.889 ± 0.041
0.358CysGln: 0.358 ± 0.026
0.785CysArg: 0.785 ± 0.031
0.774CysSer: 0.774 ± 0.039
0.86CysThr: 0.86 ± 0.034
1.189CysVal: 1.189 ± 0.048
0.167CysTrp: 0.167 ± 0.013
0.408CysTyr: 0.408 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
8.196AspAla: 8.196 ± 0.181
0.666AspCys: 0.666 ± 0.033
3.883AspAsp: 3.883 ± 0.124
5.3AspGlu: 5.3 ± 0.104
2.456AspPhe: 2.456 ± 0.065
6.084AspGly: 6.084 ± 0.273
0.949AspHis: 0.949 ± 0.035
2.939AspIle: 2.939 ± 0.063
1.941AspLys: 1.941 ± 0.092
4.992AspLeu: 4.992 ± 0.086
1.505AspMet: 1.505 ± 0.042
1.596AspAsn: 1.596 ± 0.098
3.113AspPro: 3.113 ± 0.079
1.323AspGln: 1.323 ± 0.045
3.241AspArg: 3.241 ± 0.064
2.588AspSer: 2.588 ± 0.087
2.921AspThr: 2.921 ± 0.115
4.46AspVal: 4.46 ± 0.083
0.723AspTrp: 0.723 ± 0.042
2.088AspTyr: 2.088 ± 0.076
0.0AspXaa: 0.0 ± 0.0
Glu
9.224GluAla: 9.224 ± 0.155
0.729GluCys: 0.729 ± 0.031
3.668GluAsp: 3.668 ± 0.082
5.024GluGlu: 5.024 ± 0.108
1.931GluPhe: 1.931 ± 0.056
6.08GluGly: 6.08 ± 0.1
1.226GluHis: 1.226 ± 0.04
2.91GluIle: 2.91 ± 0.075
2.936GluLys: 2.936 ± 0.075
5.759GluLeu: 5.759 ± 0.105
1.756GluMet: 1.756 ± 0.051
2.166GluAsn: 2.166 ± 0.069
2.956GluPro: 2.956 ± 0.074
2.022GluGln: 2.022 ± 0.054
5.015GluArg: 5.015 ± 0.118
3.109GluSer: 3.109 ± 0.077
3.25GluThr: 3.25 ± 0.076
5.1GluVal: 5.1 ± 0.084
0.69GluTrp: 0.69 ± 0.03
1.694GluTyr: 1.694 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
4.564PheAla: 4.564 ± 0.107
0.633PheCys: 0.633 ± 0.032
2.722PheAsp: 2.722 ± 0.056
2.231PheGlu: 2.231 ± 0.058
1.439PhePhe: 1.439 ± 0.053
3.457PheGly: 3.457 ± 0.076
0.531PheHis: 0.531 ± 0.027
1.644PheIle: 1.644 ± 0.05
1.163PheLys: 1.163 ± 0.039
3.077PheLeu: 3.077 ± 0.094
0.906PheMet: 0.906 ± 0.037
1.111PheAsn: 1.111 ± 0.045
1.471PhePro: 1.471 ± 0.049
0.884PheGln: 0.884 ± 0.032
1.678PheArg: 1.678 ± 0.052
2.357PheSer: 2.357 ± 0.056
2.106PheThr: 2.106 ± 0.053
2.855PheVal: 2.855 ± 0.065
0.471PheTrp: 0.471 ± 0.023
1.125PheTyr: 1.125 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
10.353GlyAla: 10.353 ± 0.156
1.697GlyCys: 1.697 ± 0.062
4.782GlyAsp: 4.782 ± 0.127
5.63GlyGlu: 5.63 ± 0.098
3.332GlyPhe: 3.332 ± 0.068
6.73GlyGly: 6.73 ± 0.12
1.425GlyHis: 1.425 ± 0.044
4.543GlyIle: 4.543 ± 0.109
3.575GlyLys: 3.575 ± 0.085
7.444GlyLeu: 7.444 ± 0.118
2.253GlyMet: 2.253 ± 0.073
2.638GlyAsn: 2.638 ± 0.124
2.516GlyPro: 2.516 ± 0.068
2.137GlyGln: 2.137 ± 0.061
5.121GlyArg: 5.121 ± 0.103
4.963GlySer: 4.963 ± 0.102
5.162GlyThr: 5.162 ± 0.152
6.691GlyVal: 6.691 ± 0.104
1.118GlyTrp: 1.118 ± 0.038
2.631GlyTyr: 2.631 ± 0.095
0.0GlyXaa: 0.0 ± 0.0
His
1.699HisAla: 1.699 ± 0.05
0.299HisCys: 0.299 ± 0.021
1.04HisAsp: 1.04 ± 0.038
1.022HisGlu: 1.022 ± 0.043
0.598HisPhe: 0.598 ± 0.03
1.62HisGly: 1.62 ± 0.046
0.373HisHis: 0.373 ± 0.023
0.835HisIle: 0.835 ± 0.031
0.477HisLys: 0.477 ± 0.027
1.525HisLeu: 1.525 ± 0.05
0.382HisMet: 0.382 ± 0.021
0.488HisAsn: 0.488 ± 0.027
1.01HisPro: 1.01 ± 0.04
0.438HisGln: 0.438 ± 0.024
1.08HisArg: 1.08 ± 0.044
0.871HisSer: 0.871 ± 0.037
0.863HisThr: 0.863 ± 0.03
1.323HisVal: 1.323 ± 0.042
0.209HisTrp: 0.209 ± 0.016
0.559HisTyr: 0.559 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
6.282IleAla: 6.282 ± 0.167
0.702IleCys: 0.702 ± 0.031
3.447IleAsp: 3.447 ± 0.067
3.497IleGlu: 3.497 ± 0.095
1.429IlePhe: 1.429 ± 0.051
3.968IleGly: 3.968 ± 0.098
0.692IleHis: 0.692 ± 0.032
2.279IleIle: 2.279 ± 0.072
1.475IleLys: 1.475 ± 0.047
3.429IleLeu: 3.429 ± 0.084
1.179IleMet: 1.179 ± 0.048
1.339IleAsn: 1.339 ± 0.047
2.263IlePro: 2.263 ± 0.061
1.08IleGln: 1.08 ± 0.042
2.276IleArg: 2.276 ± 0.069
2.521IleSer: 2.521 ± 0.07
2.643IleThr: 2.643 ± 0.059
4.338IleVal: 4.338 ± 0.087
0.431IleTrp: 0.431 ± 0.02
1.223IleTyr: 1.223 ± 0.042
0.0IleXaa: 0.0 ± 0.0
Lys
4.138LysAla: 4.138 ± 0.091
0.453LysCys: 0.453 ± 0.023
1.95LysAsp: 1.95 ± 0.078
2.167LysGlu: 2.167 ± 0.057
0.897LysPhe: 0.897 ± 0.036
2.882LysGly: 2.882 ± 0.076
0.584LysHis: 0.584 ± 0.028
1.667LysIle: 1.667 ± 0.052
2.267LysLys: 2.267 ± 0.085
3.156LysLeu: 3.156 ± 0.074
1.032LysMet: 1.032 ± 0.035
1.223LysAsn: 1.223 ± 0.059
1.716LysPro: 1.716 ± 0.061
1.06LysGln: 1.06 ± 0.045
2.481LysArg: 2.481 ± 0.061
2.013LysSer: 2.013 ± 0.06
2.245LysThr: 2.245 ± 0.085
2.788LysVal: 2.788 ± 0.08
0.395LysTrp: 0.395 ± 0.024
1.026LysTyr: 1.026 ± 0.041
0.0LysXaa: 0.0 ± 0.0
Leu
12.755LeuAla: 12.755 ± 0.238
1.397LeuCys: 1.397 ± 0.047
5.233LeuAsp: 5.233 ± 0.097
5.026LeuGlu: 5.026 ± 0.12
3.466LeuPhe: 3.466 ± 0.082
7.36LeuGly: 7.36 ± 0.137
1.291LeuHis: 1.291 ± 0.049
3.943LeuIle: 3.943 ± 0.107
2.992LeuLys: 2.992 ± 0.067
8.069LeuLeu: 8.069 ± 0.208
2.455LeuMet: 2.455 ± 0.072
2.289LeuAsn: 2.289 ± 0.064
4.32LeuPro: 4.32 ± 0.081
1.965LeuGln: 1.965 ± 0.05
5.344LeuArg: 5.344 ± 0.122
5.525LeuSer: 5.525 ± 0.112
5.093LeuThr: 5.093 ± 0.09
7.692LeuVal: 7.692 ± 0.151
1.04LeuTrp: 1.04 ± 0.036
2.347LeuTyr: 2.347 ± 0.048
0.0LeuXaa: 0.0 ± 0.0
Met
3.442MetAla: 3.442 ± 0.094
0.284MetCys: 0.284 ± 0.02
1.392MetAsp: 1.392 ± 0.041
1.638MetGlu: 1.638 ± 0.056
0.854MetPhe: 0.854 ± 0.04
2.263MetGly: 2.263 ± 0.057
0.38MetHis: 0.38 ± 0.018
1.086MetIle: 1.086 ± 0.045
1.021MetLys: 1.021 ± 0.041
2.278MetLeu: 2.278 ± 0.074
0.65MetMet: 0.65 ± 0.036
0.923MetAsn: 0.923 ± 0.033
1.275MetPro: 1.275 ± 0.037
0.691MetGln: 0.691 ± 0.034
1.674MetArg: 1.674 ± 0.057
1.38MetSer: 1.38 ± 0.045
1.664MetThr: 1.664 ± 0.049
1.866MetVal: 1.866 ± 0.057
0.207MetTrp: 0.207 ± 0.017
0.549MetTyr: 0.549 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
3.258AsnAla: 3.258 ± 0.114
0.393AsnCys: 0.393 ± 0.024
1.782AsnAsp: 1.782 ± 0.095
1.869AsnGlu: 1.869 ± 0.07
0.996AsnPhe: 0.996 ± 0.039
2.482AsnGly: 2.482 ± 0.124
0.515AsnHis: 0.515 ± 0.026
1.368AsnIle: 1.368 ± 0.042
0.962AsnLys: 0.962 ± 0.056
2.59AsnLeu: 2.59 ± 0.062
0.764AsnMet: 0.764 ± 0.032
0.873AsnAsn: 0.873 ± 0.057
1.932AsnPro: 1.932 ± 0.054
0.749AsnGln: 0.749 ± 0.036
1.623AsnArg: 1.623 ± 0.048
1.393AsnSer: 1.393 ± 0.062
1.537AsnThr: 1.537 ± 0.067
2.159AsnVal: 2.159 ± 0.073
0.36AsnTrp: 0.36 ± 0.03
0.904AsnTyr: 0.904 ± 0.06
0.0AsnXaa: 0.0 ± 0.0
Pro
6.339ProAla: 6.339 ± 0.127
0.566ProCys: 0.566 ± 0.027
3.15ProAsp: 3.15 ± 0.072
3.808ProGlu: 3.808 ± 0.082
1.818ProPhe: 1.818 ± 0.048
3.477ProGly: 3.477 ± 0.075
0.86ProHis: 0.86 ± 0.032
1.842ProIle: 1.842 ± 0.046
1.45ProLys: 1.45 ± 0.048
4.091ProLeu: 4.091 ± 0.082
0.975ProMet: 0.975 ± 0.036
1.153ProAsn: 1.153 ± 0.052
1.45ProPro: 1.45 ± 0.051
1.301ProGln: 1.301 ± 0.04
2.345ProArg: 2.345 ± 0.069
2.681ProSer: 2.681 ± 0.058
2.539ProThr: 2.539 ± 0.065
3.915ProVal: 3.915 ± 0.067
0.609ProTrp: 0.609 ± 0.025
1.451ProTyr: 1.451 ± 0.055
0.0ProXaa: 0.0 ± 0.0
Gln
3.38GlnAla: 3.38 ± 0.074
0.331GlnCys: 0.331 ± 0.023
1.184GlnAsp: 1.184 ± 0.044
1.627GlnGlu: 1.627 ± 0.046
0.905GlnPhe: 0.905 ± 0.035
1.961GlnGly: 1.961 ± 0.05
0.434GlnHis: 0.434 ± 0.024
1.352GlnIle: 1.352 ± 0.044
1.113GlnLys: 1.113 ± 0.04
2.387GlnLeu: 2.387 ± 0.057
0.793GlnMet: 0.793 ± 0.04
0.885GlnAsn: 0.885 ± 0.047
1.228GlnPro: 1.228 ± 0.039
0.962GlnGln: 0.962 ± 0.041
1.826GlnArg: 1.826 ± 0.053
1.388GlnSer: 1.388 ± 0.048
1.416GlnThr: 1.416 ± 0.051
2.056GlnVal: 2.056 ± 0.051
0.43GlnTrp: 0.43 ± 0.04
0.705GlnTyr: 0.705 ± 0.041
0.0GlnXaa: 0.0 ± 0.0
Arg
7.231ArgAla: 7.231 ± 0.155
0.93ArgCys: 0.93 ± 0.039
3.496ArgAsp: 3.496 ± 0.062
4.595ArgGlu: 4.595 ± 0.131
2.286ArgPhe: 2.286 ± 0.055
4.281ArgGly: 4.281 ± 0.098
1.186ArgHis: 1.186 ± 0.043
3.103ArgIle: 3.103 ± 0.066
2.293ArgLys: 2.293 ± 0.07
5.082ArgLeu: 5.082 ± 0.135
1.696ArgMet: 1.696 ± 0.052
1.667ArgAsn: 1.667 ± 0.048
2.634ArgPro: 2.634 ± 0.061
1.701ArgGln: 1.701 ± 0.047
4.576ArgArg: 4.576 ± 0.124
3.1ArgSer: 3.1 ± 0.07
3.237ArgThr: 3.237 ± 0.067
4.174ArgVal: 4.174 ± 0.073
0.722ArgTrp: 0.722 ± 0.03
1.932ArgTyr: 1.932 ± 0.048
0.0ArgXaa: 0.0 ± 0.0
Ser
6.252SerAla: 6.252 ± 0.115
0.834SerCys: 0.834 ± 0.038
3.18SerAsp: 3.18 ± 0.085
3.124SerGlu: 3.124 ± 0.067
2.427SerPhe: 2.427 ± 0.052
4.84SerGly: 4.84 ± 0.095
1.001SerHis: 1.001 ± 0.035
2.594SerIle: 2.594 ± 0.078
1.906SerLys: 1.906 ± 0.062
5.331SerLeu: 5.331 ± 0.114
1.477SerMet: 1.477 ± 0.042
1.503SerAsn: 1.503 ± 0.072
2.427SerPro: 2.427 ± 0.058
1.595SerGln: 1.595 ± 0.042
3.301SerArg: 3.301 ± 0.068
3.37SerSer: 3.37 ± 0.084
2.804SerThr: 2.804 ± 0.073
4.339SerVal: 4.339 ± 0.075
0.781SerTrp: 0.781 ± 0.032
1.794SerTyr: 1.794 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
6.221ThrAla: 6.221 ± 0.119
0.806ThrCys: 0.806 ± 0.031
3.395ThrAsp: 3.395 ± 0.183
3.097ThrGlu: 3.097 ± 0.089
2.097ThrPhe: 2.097 ± 0.06
4.992ThrGly: 4.992 ± 0.125
0.893ThrHis: 0.893 ± 0.03
2.695ThrIle: 2.695 ± 0.07
1.724ThrLys: 1.724 ± 0.08
5.075ThrLeu: 5.075 ± 0.086
1.274ThrMet: 1.274 ± 0.037
1.433ThrAsn: 1.433 ± 0.063
3.054ThrPro: 3.054 ± 0.07
1.317ThrGln: 1.317 ± 0.06
2.695ThrArg: 2.695 ± 0.069
2.97ThrSer: 2.97 ± 0.086
3.046ThrThr: 3.046 ± 0.145
5.104ThrVal: 5.104 ± 0.108
0.698ThrTrp: 0.698 ± 0.033
1.846ThrTyr: 1.846 ± 0.099
0.0ThrXaa: 0.0 ± 0.0
Val
10.143ValAla: 10.143 ± 0.149
1.296ValCys: 1.296 ± 0.053
4.811ValAsp: 4.811 ± 0.107
5.128ValGlu: 5.128 ± 0.091
3.002ValPhe: 3.002 ± 0.094
6.113ValGly: 6.113 ± 0.104
1.273ValHis: 1.273 ± 0.043
3.835ValIle: 3.835 ± 0.089
2.772ValLys: 2.772 ± 0.071
7.49ValLeu: 7.49 ± 0.134
1.84ValMet: 1.84 ± 0.064
2.435ValAsn: 2.435 ± 0.078
4.049ValPro: 4.049 ± 0.078
1.946ValGln: 1.946 ± 0.053
4.781ValArg: 4.781 ± 0.087
4.81ValSer: 4.81 ± 0.079
4.606ValThr: 4.606 ± 0.139
7.154ValVal: 7.154 ± 0.113
0.84ValTrp: 0.84 ± 0.04
2.179ValTyr: 2.179 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
1.152TrpAla: 1.152 ± 0.042
0.226TrpCys: 0.226 ± 0.018
0.731TrpAsp: 0.731 ± 0.032
0.793TrpGlu: 0.793 ± 0.031
0.466TrpPhe: 0.466 ± 0.027
1.041TrpGly: 1.041 ± 0.035
0.266TrpHis: 0.266 ± 0.018
0.567TrpIle: 0.567 ± 0.024
0.429TrpLys: 0.429 ± 0.025
1.235TrpLeu: 1.235 ± 0.046
0.338TrpMet: 0.338 ± 0.02
0.431TrpAsn: 0.431 ± 0.03
0.423TrpPro: 0.423 ± 0.021
0.347TrpGln: 0.347 ± 0.02
0.747TrpArg: 0.747 ± 0.03
0.614TrpSer: 0.614 ± 0.029
0.549TrpThr: 0.549 ± 0.035
0.896TrpVal: 0.896 ± 0.043
0.16TrpTrp: 0.16 ± 0.014
0.328TrpTyr: 0.328 ± 0.031
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.041TyrAla: 3.041 ± 0.064
0.414TyrCys: 0.414 ± 0.022
2.208TyrAsp: 2.208 ± 0.117
1.958TyrGlu: 1.958 ± 0.058
1.082TyrPhe: 1.082 ± 0.041
2.537TyrGly: 2.537 ± 0.068
0.509TyrHis: 0.509 ± 0.027
1.19TyrIle: 1.19 ± 0.044
0.957TyrLys: 0.957 ± 0.054
2.861TyrLeu: 2.861 ± 0.066
0.609TyrMet: 0.609 ± 0.024
0.925TyrAsn: 0.925 ± 0.067
1.267TyrPro: 1.267 ± 0.039
0.93TyrGln: 0.93 ± 0.036
1.937TyrArg: 1.937 ± 0.058
1.377TyrSer: 1.377 ± 0.045
1.62TyrThr: 1.62 ± 0.113
2.237TyrVal: 2.237 ± 0.085
0.315TyrTrp: 0.315 ± 0.026
1.044TyrTyr: 1.044 ± 0.07
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2435 proteins (846340 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski