Amino acid dipepetide frequency for Akkermansia glycaniphila

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.197AlaAla: 12.197 ± 0.175	1.658AlaCys: 1.658 ± 0.053	5.703AlaAsp: 5.703 ± 0.093	6.114AlaGlu: 6.114 ± 0.115	3.502AlaPhe: 3.502 ± 0.07	7.765AlaGly: 7.765 ± 0.152	1.796AlaHis: 1.796 ± 0.044	4.896AlaIle: 4.896 ± 0.098	4.095AlaLys: 4.095 ± 0.078	9.704AlaLeu: 9.704 ± 0.13	2.811AlaMet: 2.811 ± 0.061	2.906AlaAsn: 2.906 ± 0.09	4.669AlaPro: 4.669 ± 0.1	3.545AlaGln: 3.545 ± 0.081	5.672AlaArg: 5.672 ± 0.092	6.073AlaSer: 6.073 ± 0.107	5.222AlaThr: 5.222 ± 0.118	6.592AlaVal: 6.592 ± 0.107	1.638AlaTrp: 1.638 ± 0.049	2.857AlaTyr: 2.857 ± 0.059	0.0AlaXaa: 0.0 ± 0.0
Cys	1.247CysAla: 1.247 ± 0.042	0.292CysCys: 0.292 ± 0.017	0.726CysAsp: 0.726 ± 0.027	0.719CysGlu: 0.719 ± 0.027	0.615CysPhe: 0.615 ± 0.027	1.302CysGly: 1.302 ± 0.046	0.339CysHis: 0.339 ± 0.02	0.9CysIle: 0.9 ± 0.029	0.504CysLys: 0.504 ± 0.025	1.412CysLeu: 1.412 ± 0.05	0.429CysMet: 0.429 ± 0.021	0.385CysAsn: 0.385 ± 0.019	0.771CysPro: 0.771 ± 0.032	0.333CysGln: 0.333 ± 0.021	1.017CysArg: 1.017 ± 0.035	0.977CysSer: 0.977 ± 0.034	0.823CysThr: 0.823 ± 0.03	0.894CysVal: 0.894 ± 0.035	0.22CysTrp: 0.22 ± 0.016	0.514CysTyr: 0.514 ± 0.031	0.0CysXaa: 0.0 ± 0.0
Asp	5.825AspAla: 5.825 ± 0.091	0.712AspCys: 0.712 ± 0.027	2.737AspAsp: 2.737 ± 0.064	3.504AspGlu: 3.504 ± 0.07	2.185AspPhe: 2.185 ± 0.046	4.863AspGly: 4.863 ± 0.097	1.054AspHis: 1.054 ± 0.033	3.384AspIle: 3.384 ± 0.076	2.724AspLys: 2.724 ± 0.065	4.903AspLeu: 4.903 ± 0.078	1.529AspMet: 1.529 ± 0.044	1.849AspAsn: 1.849 ± 0.055	2.755AspPro: 2.755 ± 0.062	1.421AspGln: 1.421 ± 0.044	3.182AspArg: 3.182 ± 0.067	3.05AspSer: 3.05 ± 0.059	2.983AspThr: 2.983 ± 0.057	3.465AspVal: 3.465 ± 0.073	0.954AspTrp: 0.954 ± 0.037	1.847AspTyr: 1.847 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	5.914GluAla: 5.914 ± 0.105	0.684GluCys: 0.684 ± 0.027	2.938GluAsp: 2.938 ± 0.067	4.458GluGlu: 4.458 ± 0.1	1.863GluPhe: 1.863 ± 0.048	4.298GluGly: 4.298 ± 0.071	1.365GluHis: 1.365 ± 0.044	3.34GluIle: 3.34 ± 0.073	3.37GluLys: 3.37 ± 0.087	5.73GluLeu: 5.73 ± 0.085	1.618GluMet: 1.618 ± 0.05	2.394GluAsn: 2.394 ± 0.055	2.549GluPro: 2.549 ± 0.061	3.052GluGln: 3.052 ± 0.067	3.82GluArg: 3.82 ± 0.07	2.844GluSer: 2.844 ± 0.061	3.619GluThr: 3.619 ± 0.078	3.263GluVal: 3.263 ± 0.089	0.982GluTrp: 0.982 ± 0.038	1.785GluTyr: 1.785 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.363PheAla: 3.363 ± 0.068	0.672PheCys: 0.672 ± 0.029	2.358PheAsp: 2.358 ± 0.058	1.822PheGlu: 1.822 ± 0.047	1.606PhePhe: 1.606 ± 0.054	3.036PheGly: 3.036 ± 0.06	0.834PheHis: 0.834 ± 0.033	1.879PheIle: 1.879 ± 0.048	1.263PheLys: 1.263 ± 0.042	3.591PheLeu: 3.591 ± 0.077	0.875PheMet: 0.875 ± 0.03	1.246PheAsn: 1.246 ± 0.042	1.686PhePro: 1.686 ± 0.047	0.981PheGln: 0.981 ± 0.033	2.307PheArg: 2.307 ± 0.056	2.687PheSer: 2.687 ± 0.061	2.105PheThr: 2.105 ± 0.054	2.336PheVal: 2.336 ± 0.06	0.554PheTrp: 0.554 ± 0.027	1.263PheTyr: 1.263 ± 0.036	0.0PheXaa: 0.0 ± 0.0
Gly	6.536GlyAla: 6.536 ± 0.158	1.234GlyCys: 1.234 ± 0.045	4.175GlyAsp: 4.175 ± 0.066	4.297GlyGlu: 4.297 ± 0.08	2.912GlyPhe: 2.912 ± 0.06	6.24GlyGly: 6.24 ± 0.182	1.753GlyHis: 1.753 ± 0.043	5.177GlyIle: 5.177 ± 0.085	4.83GlyLys: 4.83 ± 0.092	6.505GlyLeu: 6.505 ± 0.075	2.419GlyMet: 2.419 ± 0.056	3.501GlyAsn: 3.501 ± 0.122	1.944GlyPro: 1.944 ± 0.053	2.522GlyGln: 2.522 ± 0.049	4.343GlyArg: 4.343 ± 0.071	5.265GlySer: 5.265 ± 0.15	5.553GlyThr: 5.553 ± 0.266	4.949GlyVal: 4.949 ± 0.095	1.317GlyTrp: 1.317 ± 0.045	2.695GlyTyr: 2.695 ± 0.054	0.0GlyXaa: 0.0 ± 0.0
His	2.24HisAla: 2.24 ± 0.052	0.301HisCys: 0.301 ± 0.017	1.157HisAsp: 1.157 ± 0.037	1.181HisGlu: 1.181 ± 0.034	0.827HisPhe: 0.827 ± 0.031	1.858HisGly: 1.858 ± 0.049	0.633HisHis: 0.633 ± 0.033	1.385HisIle: 1.385 ± 0.046	0.716HisLys: 0.716 ± 0.029	2.249HisLeu: 2.249 ± 0.052	0.475HisMet: 0.475 ± 0.025	0.673HisAsn: 0.673 ± 0.032	1.532HisPro: 1.532 ± 0.046	0.643HisGln: 0.643 ± 0.026	1.29HisArg: 1.29 ± 0.044	1.214HisSer: 1.214 ± 0.035	1.311HisThr: 1.311 ± 0.039	1.249HisVal: 1.249 ± 0.036	0.34HisTrp: 0.34 ± 0.02	0.733HisTyr: 0.733 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	5.669IleAla: 5.669 ± 0.094	0.83IleCys: 0.83 ± 0.033	3.417IleAsp: 3.417 ± 0.059	3.119IleGlu: 3.119 ± 0.07	1.94IlePhe: 1.94 ± 0.058	4.218IleGly: 4.218 ± 0.074	1.206IleHis: 1.206 ± 0.035	2.797IleIle: 2.797 ± 0.072	1.931IleLys: 1.931 ± 0.058	5.589IleLeu: 5.589 ± 0.101	1.118IleMet: 1.118 ± 0.041	1.892IleAsn: 1.892 ± 0.051	3.209IlePro: 3.209 ± 0.065	1.636IleGln: 1.636 ± 0.048	3.593IleArg: 3.593 ± 0.064	3.477IleSer: 3.477 ± 0.069	3.155IleThr: 3.155 ± 0.084	4.022IleVal: 4.022 ± 0.074	0.646IleTrp: 0.646 ± 0.026	1.553IleTyr: 1.553 ± 0.048	0.0IleXaa: 0.0 ± 0.0
Lys	4.81LysAla: 4.81 ± 0.102	0.395LysCys: 0.395 ± 0.021	2.791LysAsp: 2.791 ± 0.076	3.149LysGlu: 3.149 ± 0.065	1.176LysPhe: 1.176 ± 0.042	3.484LysGly: 3.484 ± 0.073	1.004LysHis: 1.004 ± 0.034	2.277LysIle: 2.277 ± 0.07	2.949LysLys: 2.949 ± 0.07	4.186LysLeu: 4.186 ± 0.068	1.27LysMet: 1.27 ± 0.038	2.095LysAsn: 2.095 ± 0.058	2.458LysPro: 2.458 ± 0.073	1.933LysGln: 1.933 ± 0.052	2.569LysArg: 2.569 ± 0.058	2.34LysSer: 2.34 ± 0.056	3.052LysThr: 3.052 ± 0.066	2.6LysVal: 2.6 ± 0.071	0.635LysTrp: 0.635 ± 0.03	1.377LysTyr: 1.377 ± 0.046	0.0LysXaa: 0.0 ± 0.0
Leu	10.122LeuAla: 10.122 ± 0.132	1.618LeuCys: 1.618 ± 0.045	5.32LeuAsp: 5.32 ± 0.081	5.17LeuGlu: 5.17 ± 0.084	3.541LeuPhe: 3.541 ± 0.079	6.875LeuGly: 6.875 ± 0.091	2.348LeuHis: 2.348 ± 0.063	4.73LeuIle: 4.73 ± 0.091	4.409LeuLys: 4.409 ± 0.071	9.688LeuLeu: 9.688 ± 0.168	2.365LeuMet: 2.365 ± 0.059	3.288LeuAsn: 3.288 ± 0.095	5.805LeuPro: 5.805 ± 0.102	3.551LeuGln: 3.551 ± 0.068	6.023LeuArg: 6.023 ± 0.097	6.367LeuSer: 6.367 ± 0.102	5.133LeuThr: 5.133 ± 0.126	5.844LeuVal: 5.844 ± 0.098	1.196LeuTrp: 1.196 ± 0.04	2.755LeuTyr: 2.755 ± 0.056	0.0LeuXaa: 0.0 ± 0.0
Met	2.624MetAla: 2.624 ± 0.056	0.302MetCys: 0.302 ± 0.017	1.424MetAsp: 1.424 ± 0.039	1.666MetGlu: 1.666 ± 0.049	0.752MetPhe: 0.752 ± 0.035	1.883MetGly: 1.883 ± 0.047	0.542MetHis: 0.542 ± 0.025	1.241MetIle: 1.241 ± 0.04	1.701MetLys: 1.701 ± 0.051	2.481MetLeu: 2.481 ± 0.062	0.757MetMet: 0.757 ± 0.035	1.236MetAsn: 1.236 ± 0.033	1.583MetPro: 1.583 ± 0.046	1.189MetGln: 1.189 ± 0.045	1.531MetArg: 1.531 ± 0.048	1.681MetSer: 1.681 ± 0.047	1.481MetThr: 1.481 ± 0.04	1.436MetVal: 1.436 ± 0.046	0.285MetTrp: 0.285 ± 0.017	0.611MetTyr: 0.611 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.428AsnAla: 3.428 ± 0.084	0.377AsnCys: 0.377 ± 0.02	1.749AsnAsp: 1.749 ± 0.046	1.783AsnGlu: 1.783 ± 0.046	1.208AsnPhe: 1.208 ± 0.039	3.407AsnGly: 3.407 ± 0.134	0.757AsnHis: 0.757 ± 0.031	2.344AsnIle: 2.344 ± 0.071	1.549AsnLys: 1.549 ± 0.045	3.322AsnLeu: 3.322 ± 0.074	1.015AsnMet: 1.015 ± 0.032	1.55AsnAsn: 1.55 ± 0.073	2.224AsnPro: 2.224 ± 0.054	1.038AsnGln: 1.038 ± 0.042	2.199AsnArg: 2.199 ± 0.046	2.008AsnSer: 2.008 ± 0.074	2.387AsnThr: 2.387 ± 0.084	2.17AsnVal: 2.17 ± 0.053	0.456AsnTrp: 0.456 ± 0.023	1.174AsnTyr: 1.174 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	5.891ProAla: 5.891 ± 0.12	0.613ProCys: 0.613 ± 0.026	3.482ProAsp: 3.482 ± 0.074	4.304ProGlu: 4.304 ± 0.09	1.811ProPhe: 1.811 ± 0.058	4.286ProGly: 4.286 ± 0.08	1.145ProHis: 1.145 ± 0.042	2.157ProIle: 2.157 ± 0.064	1.979ProLys: 1.979 ± 0.048	4.426ProLeu: 4.426 ± 0.087	1.15ProMet: 1.15 ± 0.038	1.571ProAsn: 1.571 ± 0.046	2.301ProPro: 2.301 ± 0.066	1.826ProGln: 1.826 ± 0.048	2.25ProArg: 2.25 ± 0.058	3.279ProSer: 3.279 ± 0.069	2.245ProThr: 2.245 ± 0.056	3.94ProVal: 3.94 ± 0.072	0.792ProTrp: 0.792 ± 0.037	1.511ProTyr: 1.511 ± 0.043	0.0ProXaa: 0.0 ± 0.0
Gln	3.833GlnAla: 3.833 ± 0.075	0.42GlnCys: 0.42 ± 0.023	1.736GlnAsp: 1.736 ± 0.044	2.302GlnGlu: 2.302 ± 0.054	1.042GlnPhe: 1.042 ± 0.038	2.77GlnGly: 2.77 ± 0.075	0.843GlnHis: 0.843 ± 0.036	1.808GlnIle: 1.808 ± 0.046	1.802GlnLys: 1.802 ± 0.05	2.993GlnLeu: 2.993 ± 0.059	0.904GlnMet: 0.904 ± 0.036	1.486GlnAsn: 1.486 ± 0.051	1.977GlnPro: 1.977 ± 0.059	1.69GlnGln: 1.69 ± 0.052	1.919GlnArg: 1.919 ± 0.048	2.06GlnSer: 2.06 ± 0.05	2.181GlnThr: 2.181 ± 0.059	1.858GlnVal: 1.858 ± 0.053	0.597GlnTrp: 0.597 ± 0.024	1.265GlnTyr: 1.265 ± 0.044	0.0GlnXaa: 0.0 ± 0.0
Arg	4.661ArgAla: 4.661 ± 0.081	0.781ArgCys: 0.781 ± 0.032	3.152ArgAsp: 3.152 ± 0.073	4.069ArgGlu: 4.069 ± 0.099	2.444ArgPhe: 2.444 ± 0.06	3.487ArgGly: 3.487 ± 0.07	1.601ArgHis: 1.601 ± 0.053	3.841ArgIle: 3.841 ± 0.069	3.23ArgLys: 3.23 ± 0.068	5.993ArgLeu: 5.993 ± 0.103	1.943ArgMet: 1.943 ± 0.062	2.301ArgAsn: 2.301 ± 0.047	2.731ArgPro: 2.731 ± 0.067	2.607ArgGln: 2.607 ± 0.069	4.282ArgArg: 4.282 ± 0.093	3.238ArgSer: 3.238 ± 0.056	3.4ArgThr: 3.4 ± 0.065	3.308ArgVal: 3.308 ± 0.073	0.857ArgTrp: 0.857 ± 0.034	1.989ArgTyr: 1.989 ± 0.049	0.0ArgXaa: 0.0 ± 0.0
Ser	5.464SerAla: 5.464 ± 0.085	1.021SerCys: 1.021 ± 0.036	3.018SerAsp: 3.018 ± 0.053	3.059SerGlu: 3.059 ± 0.078	2.63SerPhe: 2.63 ± 0.06	5.817SerGly: 5.817 ± 0.159	1.185SerHis: 1.185 ± 0.04	3.728SerIle: 3.728 ± 0.063	2.337SerLys: 2.337 ± 0.063	6.253SerLeu: 6.253 ± 0.101	1.738SerMet: 1.738 ± 0.042	1.873SerAsn: 1.873 ± 0.066	3.328SerPro: 3.328 ± 0.063	1.783SerGln: 1.783 ± 0.046	3.609SerArg: 3.609 ± 0.063	4.398SerSer: 4.398 ± 0.131	3.173SerThr: 3.173 ± 0.085	3.98SerVal: 3.98 ± 0.08	0.932SerTrp: 0.932 ± 0.029	1.929SerTyr: 1.929 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	5.725ThrAla: 5.725 ± 0.128	0.749ThrCys: 0.749 ± 0.033	2.911ThrAsp: 2.911 ± 0.067	2.878ThrGlu: 2.878 ± 0.066	2.108ThrPhe: 2.108 ± 0.05	5.018ThrGly: 5.018 ± 0.187	1.152ThrHis: 1.152 ± 0.037	3.394ThrIle: 3.394 ± 0.079	1.991ThrLys: 1.991 ± 0.049	6.45ThrLeu: 6.45 ± 0.205	1.27ThrMet: 1.27 ± 0.043	1.702ThrAsn: 1.702 ± 0.058	3.903ThrPro: 3.903 ± 0.081	1.705ThrGln: 1.705 ± 0.047	3.001ThrArg: 3.001 ± 0.066	3.268ThrSer: 3.268 ± 0.079	3.19ThrThr: 3.19 ± 0.105	4.356ThrVal: 4.356 ± 0.106	0.923ThrTrp: 0.923 ± 0.04	1.782ThrTyr: 1.782 ± 0.059	0.0ThrXaa: 0.0 ± 0.0
Val	5.827ValAla: 5.827 ± 0.101	1.079ValCys: 1.079 ± 0.039	3.37ValAsp: 3.37 ± 0.071	3.764ValGlu: 3.764 ± 0.085	2.557ValPhe: 2.557 ± 0.06	3.879ValGly: 3.879 ± 0.076	1.365ValHis: 1.365 ± 0.037	3.255ValIle: 3.255 ± 0.065	2.903ValLys: 2.903 ± 0.073	6.181ValLeu: 6.181 ± 0.102	1.515ValMet: 1.515 ± 0.045	2.192ValAsn: 2.192 ± 0.063	3.461ValPro: 3.461 ± 0.082	2.365ValGln: 2.365 ± 0.059	4.32ValArg: 4.32 ± 0.083	4.338ValSer: 4.338 ± 0.081	3.612ValThr: 3.612 ± 0.085	4.212ValVal: 4.212 ± 0.094	1.038ValTrp: 1.038 ± 0.039	1.871ValTyr: 1.871 ± 0.051	0.0ValXaa: 0.0 ± 0.0
Trp	1.009TrpAla: 1.009 ± 0.036	0.248TrpCys: 0.248 ± 0.016	0.89TrpAsp: 0.89 ± 0.03	0.872TrpGlu: 0.872 ± 0.036	0.529TrpPhe: 0.529 ± 0.026	0.984TrpGly: 0.984 ± 0.035	0.401TrpHis: 0.401 ± 0.022	0.817TrpIle: 0.817 ± 0.032	1.01TrpLys: 1.01 ± 0.037	1.532TrpLeu: 1.532 ± 0.048	0.513TrpMet: 0.513 ± 0.027	0.806TrpAsn: 0.806 ± 0.032	0.501TrpPro: 0.501 ± 0.023	0.719TrpGln: 0.719 ± 0.029	0.846TrpArg: 0.846 ± 0.037	0.95TrpSer: 0.95 ± 0.041	0.872TrpThr: 0.872 ± 0.03	0.827TrpVal: 0.827 ± 0.035	0.294TrpTrp: 0.294 ± 0.021	0.496TrpTyr: 0.496 ± 0.029	0.0TrpXaa: 0.0 ± 0.0
Tyr	3.031TyrAla: 3.031 ± 0.068	0.432TyrCys: 0.432 ± 0.023	1.872TyrAsp: 1.872 ± 0.057	1.657TyrGlu: 1.657 ± 0.042	1.213TyrPhe: 1.213 ± 0.037	2.696TyrGly: 2.696 ± 0.049	0.685TyrHis: 0.685 ± 0.028	1.667TyrIle: 1.667 ± 0.047	1.256TyrLys: 1.256 ± 0.039	2.961TyrLeu: 2.961 ± 0.059	0.69TyrMet: 0.69 ± 0.026	1.202TyrAsn: 1.202 ± 0.045	1.569TyrPro: 1.569 ± 0.05	0.95TyrGln: 0.95 ± 0.034	2.141TyrArg: 2.141 ± 0.057	1.745TyrSer: 1.745 ± 0.054	1.978TyrThr: 1.978 ± 0.056	1.804TyrVal: 1.804 ± 0.049	0.46TyrTrp: 0.46 ± 0.025	1.125TyrTyr: 1.125 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2530 proteins (925710 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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