Amino acid dipepetide frequency for Streptomyces sp. Ag109_O5-1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	20.527AlaAla: 20.527 ± 0.114	1.06AlaCys: 1.06 ± 0.018	8.312AlaAsp: 8.312 ± 0.062	8.48AlaGlu: 8.48 ± 0.073	3.5AlaPhe: 3.5 ± 0.038	12.729AlaGly: 12.729 ± 0.077	2.933AlaHis: 2.933 ± 0.033	3.504AlaIle: 3.504 ± 0.038	2.92AlaLys: 2.92 ± 0.038	14.148AlaLeu: 14.148 ± 0.086	2.437AlaMet: 2.437 ± 0.027	2.065AlaAsn: 2.065 ± 0.025	6.88AlaPro: 6.88 ± 0.066	3.917AlaGln: 3.917 ± 0.037	9.974AlaArg: 9.974 ± 0.064	6.065AlaSer: 6.065 ± 0.047	7.202AlaThr: 7.202 ± 0.062	12.182AlaVal: 12.182 ± 0.084	1.895AlaTrp: 1.895 ± 0.024	2.803AlaTyr: 2.803 ± 0.03	0.0AlaXaa: 0.0 ± 0.0
Cys	1.056CysAla: 1.056 ± 0.019	0.1CysCys: 0.1 ± 0.006	0.463CysAsp: 0.463 ± 0.013	0.393CysGlu: 0.393 ± 0.012	0.223CysPhe: 0.223 ± 0.008	0.934CysGly: 0.934 ± 0.017	0.203CysHis: 0.203 ± 0.007	0.186CysIle: 0.186 ± 0.008	0.118CysLys: 0.118 ± 0.005	0.794CysLeu: 0.794 ± 0.015	0.139CysMet: 0.139 ± 0.007	0.147CysAsn: 0.147 ± 0.006	0.496CysPro: 0.496 ± 0.013	0.192CysGln: 0.192 ± 0.008	0.614CysArg: 0.614 ± 0.017	0.468CysSer: 0.468 ± 0.012	0.556CysThr: 0.556 ± 0.013	0.656CysVal: 0.656 ± 0.014	0.141CysTrp: 0.141 ± 0.007	0.172CysTyr: 0.172 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	7.365AspAla: 7.365 ± 0.065	0.434AspCys: 0.434 ± 0.012	3.6AspAsp: 3.6 ± 0.037	3.673AspGlu: 3.673 ± 0.038	1.716AspPhe: 1.716 ± 0.025	6.352AspGly: 6.352 ± 0.05	1.468AspHis: 1.468 ± 0.025	1.908AspIle: 1.908 ± 0.028	1.183AspLys: 1.183 ± 0.025	6.176AspLeu: 6.176 ± 0.047	0.825AspMet: 0.825 ± 0.015	1.045AspAsn: 1.045 ± 0.02	4.48AspPro: 4.48 ± 0.042	1.604AspGln: 1.604 ± 0.026	4.804AspArg: 4.804 ± 0.046	2.694AspSer: 2.694 ± 0.029	3.38AspThr: 3.38 ± 0.041	4.708AspVal: 4.708 ± 0.044	1.065AspTrp: 1.065 ± 0.017	1.197AspTyr: 1.197 ± 0.02	0.0AspXaa: 0.0 ± 0.0
Glu	6.94GluAla: 6.94 ± 0.062	0.358GluCys: 0.358 ± 0.011	2.673GluAsp: 2.673 ± 0.032	3.358GluGlu: 3.358 ± 0.042	1.435GluPhe: 1.435 ± 0.025	4.063GluGly: 4.063 ± 0.042	1.542GluHis: 1.542 ± 0.023	2.146GluIle: 2.146 ± 0.027	1.323GluLys: 1.323 ± 0.024	6.593GluLeu: 6.593 ± 0.051	0.821GluMet: 0.821 ± 0.015	1.014GluAsn: 1.014 ± 0.02	3.215GluPro: 3.215 ± 0.038	2.258GluGln: 2.258 ± 0.03	5.095GluArg: 5.095 ± 0.052	2.55GluSer: 2.55 ± 0.029	2.88GluThr: 2.88 ± 0.033	4.272GluVal: 4.272 ± 0.042	0.793GluTrp: 0.793 ± 0.015	1.123GluTyr: 1.123 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.696PheAla: 3.696 ± 0.039	0.254PheCys: 0.254 ± 0.008	1.967PheAsp: 1.967 ± 0.026	1.438PheGlu: 1.438 ± 0.022	0.907PhePhe: 0.907 ± 0.02	3.039PheGly: 3.039 ± 0.034	0.641PheHis: 0.641 ± 0.015	0.692PheIle: 0.692 ± 0.016	0.531PheLys: 0.531 ± 0.014	2.555PheLeu: 2.555 ± 0.031	0.421PheMet: 0.421 ± 0.01	0.593PheAsn: 0.593 ± 0.014	1.407PhePro: 1.407 ± 0.022	0.725PheGln: 0.725 ± 0.013	1.877PheArg: 1.877 ± 0.024	1.449PheSer: 1.449 ± 0.022	2.046PheThr: 2.046 ± 0.028	2.268PheVal: 2.268 ± 0.029	0.437PheTrp: 0.437 ± 0.012	0.596PheTyr: 0.596 ± 0.013	0.0PheXaa: 0.0 ± 0.0
Gly	10.6GlyAla: 10.6 ± 0.067	0.833GlyCys: 0.833 ± 0.016	5.123GlyAsp: 5.123 ± 0.046	4.747GlyGlu: 4.747 ± 0.035	2.855GlyPhe: 2.855 ± 0.034	8.451GlyGly: 8.451 ± 0.076	2.417GlyHis: 2.417 ± 0.031	3.483GlyIle: 3.483 ± 0.039	2.437GlyLys: 2.437 ± 0.031	9.291GlyLeu: 9.291 ± 0.067	1.928GlyMet: 1.928 ± 0.023	1.893GlyAsn: 1.893 ± 0.028	4.918GlyPro: 4.918 ± 0.048	2.737GlyGln: 2.737 ± 0.034	7.679GlyArg: 7.679 ± 0.06	5.627GlySer: 5.627 ± 0.047	6.626GlyThr: 6.626 ± 0.06	7.449GlyVal: 7.449 ± 0.068	1.751GlyTrp: 1.751 ± 0.024	2.382GlyTyr: 2.382 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.726HisAla: 2.726 ± 0.03	0.204HisCys: 0.204 ± 0.008	1.397HisAsp: 1.397 ± 0.021	1.214HisGlu: 1.214 ± 0.021	0.671HisPhe: 0.671 ± 0.014	2.485HisGly: 2.485 ± 0.03	0.743HisHis: 0.743 ± 0.017	0.773HisIle: 0.773 ± 0.015	0.386HisLys: 0.386 ± 0.01	2.45HisLeu: 2.45 ± 0.03	0.349HisMet: 0.349 ± 0.012	0.418HisAsn: 0.418 ± 0.011	1.86HisPro: 1.86 ± 0.026	0.695HisGln: 0.695 ± 0.016	2.189HisArg: 2.189 ± 0.029	1.104HisSer: 1.104 ± 0.02	1.452HisThr: 1.452 ± 0.024	1.718HisVal: 1.718 ± 0.025	0.406HisTrp: 0.406 ± 0.01	0.517HisTyr: 0.517 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	4.769IleAla: 4.769 ± 0.047	0.28IleCys: 0.28 ± 0.009	2.273IleAsp: 2.273 ± 0.029	1.904IleGlu: 1.904 ± 0.028	0.683IlePhe: 0.683 ± 0.017	3.525IleGly: 3.525 ± 0.034	0.646IleHis: 0.646 ± 0.015	0.839IleIle: 0.839 ± 0.016	0.736IleLys: 0.736 ± 0.017	2.457IleLeu: 2.457 ± 0.03	0.44IleMet: 0.44 ± 0.012	0.726IleAsn: 0.726 ± 0.016	1.876IlePro: 1.876 ± 0.023	0.778IleGln: 0.778 ± 0.016	2.332IleArg: 2.332 ± 0.028	1.73IleSer: 1.73 ± 0.024	2.341IleThr: 2.341 ± 0.031	2.726IleVal: 2.726 ± 0.035	0.387IleTrp: 0.387 ± 0.01	0.564IleTyr: 0.564 ± 0.013	0.0IleXaa: 0.0 ± 0.0
Lys	3.015LysAla: 3.015 ± 0.038	0.118LysCys: 0.118 ± 0.005	1.32LysAsp: 1.32 ± 0.023	1.094LysGlu: 1.094 ± 0.02	0.461LysPhe: 0.461 ± 0.011	1.852LysGly: 1.852 ± 0.029	0.455LysHis: 0.455 ± 0.011	0.87LysIle: 0.87 ± 0.017	0.846LysLys: 0.846 ± 0.022	2.03LysLeu: 2.03 ± 0.03	0.367LysMet: 0.367 ± 0.011	0.593LysAsn: 0.593 ± 0.016	1.337LysPro: 1.337 ± 0.024	0.724LysGln: 0.724 ± 0.016	1.437LysArg: 1.437 ± 0.023	1.214LysSer: 1.214 ± 0.021	1.359LysThr: 1.359 ± 0.024	1.922LysVal: 1.922 ± 0.026	0.303LysTrp: 0.303 ± 0.009	0.493LysTyr: 0.493 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	14.942LeuAla: 14.942 ± 0.091	0.867LeuCys: 0.867 ± 0.02	6.651LeuAsp: 6.651 ± 0.05	4.452LeuGlu: 4.452 ± 0.044	2.597LeuPhe: 2.597 ± 0.037	9.064LeuGly: 9.064 ± 0.059	2.338LeuHis: 2.338 ± 0.031	3.249LeuIle: 3.249 ± 0.038	2.06LeuLys: 2.06 ± 0.027	11.105LeuLeu: 11.105 ± 0.089	1.572LeuMet: 1.572 ± 0.024	1.744LeuAsn: 1.744 ± 0.024	6.501LeuPro: 6.501 ± 0.048	2.324LeuGln: 2.324 ± 0.029	8.463LeuArg: 8.463 ± 0.062	5.345LeuSer: 5.345 ± 0.041	7.166LeuThr: 7.166 ± 0.058	8.718LeuVal: 8.718 ± 0.052	1.334LeuTrp: 1.334 ± 0.023	1.967LeuTyr: 1.967 ± 0.026	0.0LeuXaa: 0.0 ± 0.0
Met	2.192MetAla: 2.192 ± 0.026	0.139MetCys: 0.139 ± 0.007	0.852MetAsp: 0.852 ± 0.014	0.705MetGlu: 0.705 ± 0.015	0.437MetPhe: 0.437 ± 0.012	1.255MetGly: 1.255 ± 0.022	0.354MetHis: 0.354 ± 0.01	0.656MetIle: 0.656 ± 0.014	0.406MetLys: 0.406 ± 0.011	1.652MetLeu: 1.652 ± 0.021	0.283MetMet: 0.283 ± 0.01	0.46MetAsn: 0.46 ± 0.011	1.104MetPro: 1.104 ± 0.018	0.452MetGln: 0.452 ± 0.013	1.346MetArg: 1.346 ± 0.021	1.328MetSer: 1.328 ± 0.02	1.607MetThr: 1.607 ± 0.021	1.234MetVal: 1.234 ± 0.022	0.227MetTrp: 0.227 ± 0.008	0.331MetTyr: 0.331 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.327AsnAla: 2.327 ± 0.029	0.182AsnCys: 0.182 ± 0.007	1.007AsnAsp: 1.007 ± 0.016	0.821AsnGlu: 0.821 ± 0.016	0.491AsnPhe: 0.491 ± 0.015	2.084AsnGly: 2.084 ± 0.032	0.432AsnHis: 0.432 ± 0.01	0.685AsnIle: 0.685 ± 0.016	0.437AsnLys: 0.437 ± 0.013	1.727AsnLeu: 1.727 ± 0.024	0.322AsnMet: 0.322 ± 0.009	0.535AsnAsn: 0.535 ± 0.033	1.405AsnPro: 1.405 ± 0.022	0.565AsnGln: 0.565 ± 0.013	1.336AsnArg: 1.336 ± 0.02	1.084AsnSer: 1.084 ± 0.019	1.28AsnThr: 1.28 ± 0.023	1.412AsnVal: 1.412 ± 0.026	0.332AsnTrp: 0.332 ± 0.009	0.468AsnTyr: 0.468 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	8.54ProAla: 8.54 ± 0.063	0.364ProCys: 0.364 ± 0.01	4.392ProAsp: 4.392 ± 0.044	4.172ProGlu: 4.172 ± 0.044	1.556ProPhe: 1.556 ± 0.022	6.409ProGly: 6.409 ± 0.047	1.45ProHis: 1.45 ± 0.022	1.325ProIle: 1.325 ± 0.019	1.266ProLys: 1.266 ± 0.022	5.371ProLeu: 5.371 ± 0.045	1.0ProMet: 1.0 ± 0.019	0.954ProAsn: 0.954 ± 0.017	3.414ProPro: 3.414 ± 0.049	1.826ProGln: 1.826 ± 0.034	3.797ProArg: 3.797 ± 0.04	3.285ProSer: 3.285 ± 0.038	3.349ProThr: 3.349 ± 0.034	5.489ProVal: 5.489 ± 0.045	0.914ProTrp: 0.914 ± 0.018	1.443ProTyr: 1.443 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.862GlnAla: 3.862 ± 0.038	0.192GlnCys: 0.192 ± 0.008	1.478GlnAsp: 1.478 ± 0.018	1.455GlnGlu: 1.455 ± 0.023	0.733GlnPhe: 0.733 ± 0.014	2.35GlnGly: 2.35 ± 0.031	0.736GlnHis: 0.736 ± 0.015	1.135GlnIle: 1.135 ± 0.021	0.642GlnLys: 0.642 ± 0.015	3.177GlnLeu: 3.177 ± 0.035	0.489GlnMet: 0.489 ± 0.011	0.557GlnAsn: 0.557 ± 0.015	1.764GlnPro: 1.764 ± 0.03	1.336GlnGln: 1.336 ± 0.026	2.407GlnArg: 2.407 ± 0.025	1.393GlnSer: 1.393 ± 0.024	1.531GlnThr: 1.531 ± 0.024	2.502GlnVal: 2.502 ± 0.035	0.533GlnTrp: 0.533 ± 0.015	0.674GlnTyr: 0.674 ± 0.015	0.0GlnXaa: 0.0 ± 0.0
Arg	9.487ArgAla: 9.487 ± 0.069	0.611ArgCys: 0.611 ± 0.016	4.089ArgAsp: 4.089 ± 0.037	4.549ArgGlu: 4.549 ± 0.044	2.3ArgPhe: 2.3 ± 0.029	5.5ArgGly: 5.5 ± 0.042	2.203ArgHis: 2.203 ± 0.028	3.256ArgIle: 3.256 ± 0.035	1.619ArgLys: 1.619 ± 0.026	8.778ArgLeu: 8.778 ± 0.066	1.674ArgMet: 1.674 ± 0.023	1.372ArgAsn: 1.372 ± 0.019	4.951ArgPro: 4.951 ± 0.046	2.429ArgGln: 2.429 ± 0.029	7.646ArgArg: 7.646 ± 0.07	3.986ArgSer: 3.986 ± 0.036	5.483ArgThr: 5.483 ± 0.041	5.756ArgVal: 5.756 ± 0.049	1.405ArgTrp: 1.405 ± 0.022	1.796ArgTyr: 1.796 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	6.99SerAla: 6.99 ± 0.051	0.448SerCys: 0.448 ± 0.014	2.822SerAsp: 2.822 ± 0.032	2.331SerGlu: 2.331 ± 0.028	1.583SerPhe: 1.583 ± 0.022	6.176SerGly: 6.176 ± 0.057	1.078SerHis: 1.078 ± 0.017	1.489SerIle: 1.489 ± 0.026	1.095SerLys: 1.095 ± 0.02	4.894SerLeu: 4.894 ± 0.042	1.086SerMet: 1.086 ± 0.016	0.993SerAsn: 0.993 ± 0.018	3.251SerPro: 3.251 ± 0.04	1.369SerGln: 1.369 ± 0.022	3.677SerArg: 3.677 ± 0.035	3.251SerSer: 3.251 ± 0.05	3.365SerThr: 3.365 ± 0.037	4.465SerVal: 4.465 ± 0.045	0.97SerTrp: 0.97 ± 0.017	1.38SerTyr: 1.38 ± 0.02	0.0SerXaa: 0.0 ± 0.0
Thr	9.41ThrAla: 9.41 ± 0.061	0.485ThrCys: 0.485 ± 0.013	3.85ThrAsp: 3.85 ± 0.04	3.248ThrGlu: 3.248 ± 0.032	1.696ThrPhe: 1.696 ± 0.024	7.057ThrGly: 7.057 ± 0.061	1.307ThrHis: 1.307 ± 0.023	1.798ThrIle: 1.798 ± 0.026	1.235ThrLys: 1.235 ± 0.025	5.856ThrLeu: 5.856 ± 0.048	0.947ThrMet: 0.947 ± 0.017	1.12ThrAsn: 1.12 ± 0.021	4.273ThrPro: 4.273 ± 0.047	1.434ThrGln: 1.434 ± 0.024	3.988ThrArg: 3.988 ± 0.042	3.501ThrSer: 3.501 ± 0.048	4.287ThrThr: 4.287 ± 0.05	6.435ThrVal: 6.435 ± 0.046	0.989ThrTrp: 0.989 ± 0.018	1.424ThrTyr: 1.424 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	10.585ValAla: 10.585 ± 0.071	0.773ValCys: 0.773 ± 0.015	4.867ValAsp: 4.867 ± 0.044	4.457ValGlu: 4.457 ± 0.041	2.489ValPhe: 2.489 ± 0.03	6.452ValGly: 6.452 ± 0.048	1.994ValHis: 1.994 ± 0.024	2.907ValIle: 2.907 ± 0.033	1.73ValLys: 1.73 ± 0.027	9.434ValLeu: 9.434 ± 0.076	1.367ValMet: 1.367 ± 0.021	1.735ValAsn: 1.735 ± 0.026	5.269ValPro: 5.269 ± 0.052	2.233ValGln: 2.233 ± 0.028	7.035ValArg: 7.035 ± 0.054	4.523ValSer: 4.523 ± 0.049	5.942ValThr: 5.942 ± 0.042	7.902ValVal: 7.902 ± 0.079	1.208ValTrp: 1.208 ± 0.02	1.683ValTyr: 1.683 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.709TrpAla: 1.709 ± 0.027	0.16TrpCys: 0.16 ± 0.008	0.845TrpAsp: 0.845 ± 0.016	0.74TrpGlu: 0.74 ± 0.017	0.53TrpPhe: 0.53 ± 0.013	1.099TrpGly: 1.099 ± 0.021	0.407TrpHis: 0.407 ± 0.012	0.583TrpIle: 0.583 ± 0.015	0.4TrpLys: 0.4 ± 0.012	1.808TrpLeu: 1.808 ± 0.022	0.284TrpMet: 0.284 ± 0.01	0.482TrpAsn: 0.482 ± 0.013	0.801TrpPro: 0.801 ± 0.018	0.689TrpGln: 0.689 ± 0.014	1.362TrpArg: 1.362 ± 0.021	1.041TrpSer: 1.041 ± 0.02	1.147TrpThr: 1.147 ± 0.02	1.003TrpVal: 1.003 ± 0.018	0.34TrpTrp: 0.34 ± 0.011	0.388TrpTyr: 0.388 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.796TyrAla: 2.796 ± 0.029	0.187TyrCys: 0.187 ± 0.007	1.694TyrAsp: 1.694 ± 0.028	1.221TyrGlu: 1.221 ± 0.021	0.677TyrPhe: 0.677 ± 0.016	2.351TyrGly: 2.351 ± 0.031	0.411TyrHis: 0.411 ± 0.011	0.532TyrIle: 0.532 ± 0.011	0.44TyrLys: 0.44 ± 0.012	2.16TyrLeu: 2.16 ± 0.027	0.268TyrMet: 0.268 ± 0.01	0.486TyrAsn: 0.486 ± 0.015	1.114TyrPro: 1.114 ± 0.021	0.661TyrGln: 0.661 ± 0.015	1.833TyrArg: 1.833 ± 0.023	1.075TyrSer: 1.075 ± 0.022	1.341TyrThr: 1.341 ± 0.025	1.768TyrVal: 1.768 ± 0.025	0.387TyrTrp: 0.387 ± 0.012	0.509TyrTyr: 0.509 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 10263 proteins (3383640 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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