Amino acid dipepetide frequency for Lacibacter luteus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.721AlaAla: 7.721 ± 0.111	0.687AlaCys: 0.687 ± 0.024	4.434AlaAsp: 4.434 ± 0.058	4.495AlaGlu: 4.495 ± 0.066	3.685AlaPhe: 3.685 ± 0.06	5.922AlaGly: 5.922 ± 0.078	1.21AlaHis: 1.21 ± 0.032	5.019AlaIle: 5.019 ± 0.069	4.867AlaLys: 4.867 ± 0.065	6.519AlaLeu: 6.519 ± 0.073	1.858AlaMet: 1.858 ± 0.04	4.126AlaAsn: 4.126 ± 0.058	2.411AlaPro: 2.411 ± 0.045	2.94AlaGln: 2.94 ± 0.045	2.336AlaArg: 2.336 ± 0.039	4.629AlaSer: 4.629 ± 0.066	4.859AlaThr: 4.859 ± 0.075	5.904AlaVal: 5.904 ± 0.069	0.95AlaTrp: 0.95 ± 0.027	2.884AlaTyr: 2.884 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.579CysAla: 0.579 ± 0.021	0.14CysCys: 0.14 ± 0.01	0.424CysAsp: 0.424 ± 0.021	0.415CysGlu: 0.415 ± 0.02	0.498CysPhe: 0.498 ± 0.02	0.703CysGly: 0.703 ± 0.029	0.158CysHis: 0.158 ± 0.011	0.62CysIle: 0.62 ± 0.022	0.568CysLys: 0.568 ± 0.022	0.722CysLeu: 0.722 ± 0.024	0.21CysMet: 0.21 ± 0.011	0.496CysAsn: 0.496 ± 0.022	0.346CysPro: 0.346 ± 0.017	0.188CysGln: 0.188 ± 0.011	0.343CysArg: 0.343 ± 0.016	0.623CysSer: 0.623 ± 0.023	0.526CysThr: 0.526 ± 0.021	0.528CysVal: 0.528 ± 0.018	0.103CysTrp: 0.103 ± 0.008	0.353CysTyr: 0.353 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.573AspAla: 4.573 ± 0.062	0.426AspCys: 0.426 ± 0.022	2.459AspAsp: 2.459 ± 0.045	3.357AspGlu: 3.357 ± 0.059	2.741AspPhe: 2.741 ± 0.042	4.001AspGly: 4.001 ± 0.071	0.925AspHis: 0.925 ± 0.024	3.212AspIle: 3.212 ± 0.05	3.406AspLys: 3.406 ± 0.051	4.224AspLeu: 4.224 ± 0.056	1.126AspMet: 1.126 ± 0.027	2.461AspAsn: 2.461 ± 0.054	1.935AspPro: 1.935 ± 0.037	1.41AspGln: 1.41 ± 0.03	1.903AspArg: 1.903 ± 0.036	2.954AspSer: 2.954 ± 0.057	2.445AspThr: 2.445 ± 0.042	3.729AspVal: 3.729 ± 0.059	0.769AspTrp: 0.769 ± 0.024	2.299AspTyr: 2.299 ± 0.043	0.0AspXaa: 0.0 ± 0.0
Glu	4.337GluAla: 4.337 ± 0.065	0.35GluCys: 0.35 ± 0.015	2.4GluAsp: 2.4 ± 0.043	4.096GluGlu: 4.096 ± 0.076	2.406GluPhe: 2.406 ± 0.039	3.311GluGly: 3.311 ± 0.044	1.014GluHis: 1.014 ± 0.025	3.875GluIle: 3.875 ± 0.062	4.904GluLys: 4.904 ± 0.067	5.798GluLeu: 5.798 ± 0.077	1.573GluMet: 1.573 ± 0.033	3.044GluAsn: 3.044 ± 0.05	1.622GluPro: 1.622 ± 0.037	2.873GluGln: 2.873 ± 0.048	2.452GluArg: 2.452 ± 0.044	2.495GluSer: 2.495 ± 0.043	3.163GluThr: 3.163 ± 0.044	3.778GluVal: 3.778 ± 0.053	0.856GluTrp: 0.856 ± 0.027	2.083GluTyr: 2.083 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	3.734PheAla: 3.734 ± 0.047	0.508PheCys: 0.508 ± 0.021	2.762PheAsp: 2.762 ± 0.044	2.679PheGlu: 2.679 ± 0.043	2.779PhePhe: 2.779 ± 0.052	3.408PheGly: 3.408 ± 0.049	0.861PheHis: 0.861 ± 0.025	3.428PheIle: 3.428 ± 0.059	2.922PheLys: 2.922 ± 0.049	4.505PheLeu: 4.505 ± 0.076	1.063PheMet: 1.063 ± 0.024	2.998PheAsn: 2.998 ± 0.048	1.745PhePro: 1.745 ± 0.032	1.562PheGln: 1.562 ± 0.031	1.997PheArg: 1.997 ± 0.041	3.755PheSer: 3.755 ± 0.057	3.539PheThr: 3.539 ± 0.053	3.302PheVal: 3.302 ± 0.041	0.645PheTrp: 0.645 ± 0.023	2.162PheTyr: 2.162 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.8GlyAla: 4.8 ± 0.064	0.7GlyCys: 0.7 ± 0.032	3.27GlyAsp: 3.27 ± 0.053	3.419GlyGlu: 3.419 ± 0.053	3.701GlyPhe: 3.701 ± 0.051	5.066GlyGly: 5.066 ± 0.088	1.137GlyHis: 1.137 ± 0.031	4.969GlyIle: 4.969 ± 0.064	5.259GlyLys: 5.259 ± 0.074	5.9GlyLeu: 5.9 ± 0.072	1.703GlyMet: 1.703 ± 0.035	4.043GlyAsn: 4.043 ± 0.067	1.542GlyPro: 1.542 ± 0.033	1.933GlyGln: 1.933 ± 0.039	2.616GlyArg: 2.616 ± 0.048	4.457GlySer: 4.457 ± 0.083	4.615GlyThr: 4.615 ± 0.085	4.479GlyVal: 4.479 ± 0.064	1.134GlyTrp: 1.134 ± 0.032	3.129GlyTyr: 3.129 ± 0.053	0.0GlyXaa: 0.0 ± 0.0
His	1.345HisAla: 1.345 ± 0.028	0.193HisCys: 0.193 ± 0.012	0.819HisAsp: 0.819 ± 0.024	0.966HisGlu: 0.966 ± 0.025	1.126HisPhe: 1.126 ± 0.032	1.065HisGly: 1.065 ± 0.026	0.517HisHis: 0.517 ± 0.021	1.281HisIle: 1.281 ± 0.029	1.065HisLys: 1.065 ± 0.028	1.858HisLeu: 1.858 ± 0.038	0.383HisMet: 0.383 ± 0.015	0.921HisAsn: 0.921 ± 0.024	0.988HisPro: 0.988 ± 0.026	0.706HisGln: 0.706 ± 0.022	0.733HisArg: 0.733 ± 0.02	1.094HisSer: 1.094 ± 0.027	1.004HisThr: 1.004 ± 0.028	1.077HisVal: 1.077 ± 0.027	0.287HisTrp: 0.287 ± 0.014	0.866HisTyr: 0.866 ± 0.026	0.0HisXaa: 0.0 ± 0.0
Ile	5.714IleAla: 5.714 ± 0.079	0.681IleCys: 0.681 ± 0.023	4.003IleAsp: 4.003 ± 0.057	4.031IleGlu: 4.031 ± 0.056	2.693IlePhe: 2.693 ± 0.048	4.447IleGly: 4.447 ± 0.06	1.248IleHis: 1.248 ± 0.032	4.503IleIle: 4.503 ± 0.065	4.508IleLys: 4.508 ± 0.053	5.283IleLeu: 5.283 ± 0.074	1.159IleMet: 1.159 ± 0.032	4.052IleAsn: 4.052 ± 0.053	2.777IlePro: 2.777 ± 0.044	2.198IleGln: 2.198 ± 0.04	2.833IleArg: 2.833 ± 0.043	4.552IleSer: 4.552 ± 0.063	4.52IleThr: 4.52 ± 0.058	4.432IleVal: 4.432 ± 0.058	0.697IleTrp: 0.697 ± 0.026	2.341IleTyr: 2.341 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	5.288LysAla: 5.288 ± 0.076	0.336LysCys: 0.336 ± 0.018	3.926LysAsp: 3.926 ± 0.047	5.383LysGlu: 5.383 ± 0.08	2.505LysPhe: 2.505 ± 0.041	4.524LysGly: 4.524 ± 0.064	1.338LysHis: 1.338 ± 0.03	4.399LysIle: 4.399 ± 0.061	5.839LysLys: 5.839 ± 0.085	6.059LysLeu: 6.059 ± 0.068	1.864LysMet: 1.864 ± 0.036	3.958LysAsn: 3.958 ± 0.049	2.85LysPro: 2.85 ± 0.051	3.709LysGln: 3.709 ± 0.06	2.837LysArg: 2.837 ± 0.04	3.425LysSer: 3.425 ± 0.049	4.304LysThr: 4.304 ± 0.058	4.183LysVal: 4.183 ± 0.052	0.982LysTrp: 0.982 ± 0.026	2.653LysTyr: 2.653 ± 0.042	0.0LysXaa: 0.0 ± 0.0
Leu	6.272LeuAla: 6.272 ± 0.087	0.825LeuCys: 0.825 ± 0.025	3.845LeuAsp: 3.845 ± 0.061	4.269LeuGlu: 4.269 ± 0.056	5.356LeuPhe: 5.356 ± 0.09	5.147LeuGly: 5.147 ± 0.064	1.916LeuHis: 1.916 ± 0.04	5.767LeuIle: 5.767 ± 0.069	6.502LeuLys: 6.502 ± 0.079	10.216LeuLeu: 10.216 ± 0.143	2.14LeuMet: 2.14 ± 0.042	5.072LeuAsn: 5.072 ± 0.066	4.114LeuPro: 4.114 ± 0.064	4.585LeuGln: 4.585 ± 0.067	3.671LeuArg: 3.671 ± 0.055	6.322LeuSer: 6.322 ± 0.067	5.348LeuThr: 5.348 ± 0.067	5.487LeuVal: 5.487 ± 0.068	1.036LeuTrp: 1.036 ± 0.031	3.419LeuTyr: 3.419 ± 0.051	0.0LeuXaa: 0.0 ± 0.0
Met	1.628MetAla: 1.628 ± 0.033	0.141MetCys: 0.141 ± 0.01	1.091MetAsp: 1.091 ± 0.029	1.358MetGlu: 1.358 ± 0.032	0.912MetPhe: 0.912 ± 0.024	1.485MetGly: 1.485 ± 0.033	0.545MetHis: 0.545 ± 0.019	1.505MetIle: 1.505 ± 0.034	2.19MetLys: 2.19 ± 0.04	2.187MetLeu: 2.187 ± 0.045	0.699MetMet: 0.699 ± 0.022	1.427MetAsn: 1.427 ± 0.03	1.067MetPro: 1.067 ± 0.03	1.301MetGln: 1.301 ± 0.03	1.033MetArg: 1.033 ± 0.032	1.346MetSer: 1.346 ± 0.03	1.031MetThr: 1.031 ± 0.026	1.226MetVal: 1.226 ± 0.033	0.253MetTrp: 0.253 ± 0.014	0.802MetTyr: 0.802 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	4.297AsnAla: 4.297 ± 0.056	0.532AsnCys: 0.532 ± 0.025	3.101AsnAsp: 3.101 ± 0.051	3.291AsnGlu: 3.291 ± 0.045	2.61AsnPhe: 2.61 ± 0.042	4.622AsnGly: 4.622 ± 0.081	0.941AsnHis: 0.941 ± 0.027	3.981AsnIle: 3.981 ± 0.053	3.743AsnLys: 3.743 ± 0.048	4.403AsnLeu: 4.403 ± 0.055	1.254AsnMet: 1.254 ± 0.031	3.789AsnAsn: 3.789 ± 0.072	2.78AsnPro: 2.78 ± 0.048	1.887AsnGln: 1.887 ± 0.032	2.442AsnArg: 2.442 ± 0.041	3.566AsnSer: 3.566 ± 0.057	3.452AsnThr: 3.452 ± 0.063	3.337AsnVal: 3.337 ± 0.057	0.913AsnTrp: 0.913 ± 0.022	2.655AsnTyr: 2.655 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	3.396ProAla: 3.396 ± 0.05	0.225ProCys: 0.225 ± 0.013	2.244ProAsp: 2.244 ± 0.039	2.306ProGlu: 2.306 ± 0.042	1.963ProPhe: 1.963 ± 0.037	2.787ProGly: 2.787 ± 0.044	0.693ProHis: 0.693 ± 0.024	1.956ProIle: 1.956 ± 0.037	2.095ProLys: 2.095 ± 0.038	3.25ProLeu: 3.25 ± 0.047	0.774ProMet: 0.774 ± 0.026	1.983ProAsn: 1.983 ± 0.038	1.048ProPro: 1.048 ± 0.031	1.435ProGln: 1.435 ± 0.034	1.03ProArg: 1.03 ± 0.03	2.361ProSer: 2.361 ± 0.042	2.088ProThr: 2.088 ± 0.044	3.689ProVal: 3.689 ± 0.051	0.455ProTrp: 0.455 ± 0.017	1.487ProTyr: 1.487 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.368GlnAla: 2.368 ± 0.041	0.262GlnCys: 0.262 ± 0.015	1.353GlnAsp: 1.353 ± 0.028	1.954GlnGlu: 1.954 ± 0.04	1.989GlnPhe: 1.989 ± 0.034	1.89GlnGly: 1.89 ± 0.034	0.925GlnHis: 0.925 ± 0.026	2.267GlnIle: 2.267 ± 0.037	2.888GlnLys: 2.888 ± 0.048	4.849GlnLeu: 4.849 ± 0.076	1.042GlnMet: 1.042 ± 0.027	2.024GlnAsn: 2.024 ± 0.039	1.672GlnPro: 1.672 ± 0.032	3.048GlnGln: 3.048 ± 0.064	1.714GlnArg: 1.714 ± 0.037	2.229GlnSer: 2.229 ± 0.035	2.573GlnThr: 2.573 ± 0.043	2.28GlnVal: 2.28 ± 0.04	0.618GlnTrp: 0.618 ± 0.023	1.682GlnTyr: 1.682 ± 0.035	0.0GlnXaa: 0.0 ± 0.0
Arg	2.204ArgAla: 2.204 ± 0.041	0.266ArgCys: 0.266 ± 0.014	1.671ArgAsp: 1.671 ± 0.036	1.993ArgGlu: 1.993 ± 0.042	2.349ArgPhe: 2.349 ± 0.045	2.116ArgGly: 2.116 ± 0.04	0.657ArgHis: 0.657 ± 0.022	3.149ArgIle: 3.149 ± 0.042	2.992ArgLys: 2.992 ± 0.052	3.726ArgLeu: 3.726 ± 0.053	1.128ArgMet: 1.128 ± 0.026	2.545ArgAsn: 2.545 ± 0.042	1.247ArgPro: 1.247 ± 0.032	1.398ArgGln: 1.398 ± 0.034	1.651ArgArg: 1.651 ± 0.035	2.419ArgSer: 2.419 ± 0.044	2.29ArgThr: 2.29 ± 0.036	2.329ArgVal: 2.329 ± 0.041	0.616ArgTrp: 0.616 ± 0.019	1.886ArgTyr: 1.886 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	4.678SerAla: 4.678 ± 0.064	0.662SerCys: 0.662 ± 0.021	2.841SerAsp: 2.841 ± 0.045	2.739SerGlu: 2.739 ± 0.047	3.975SerPhe: 3.975 ± 0.059	4.779SerGly: 4.779 ± 0.08	0.944SerHis: 0.944 ± 0.026	4.654SerIle: 4.654 ± 0.059	4.012SerLys: 4.012 ± 0.054	5.668SerLeu: 5.668 ± 0.065	1.356SerMet: 1.356 ± 0.028	3.747SerAsn: 3.747 ± 0.075	2.206SerPro: 2.206 ± 0.035	1.723SerGln: 1.723 ± 0.038	2.154SerArg: 2.154 ± 0.039	4.397SerSer: 4.397 ± 0.082	3.98SerThr: 3.98 ± 0.068	4.365SerVal: 4.365 ± 0.055	0.873SerTrp: 0.873 ± 0.027	2.66SerTyr: 2.66 ± 0.043	0.0SerXaa: 0.0 ± 0.0
Thr	5.696ThrAla: 5.696 ± 0.083	0.429ThrCys: 0.429 ± 0.02	3.445ThrAsp: 3.445 ± 0.062	3.195ThrGlu: 3.195 ± 0.056	2.688ThrPhe: 2.688 ± 0.048	5.247ThrGly: 5.247 ± 0.077	1.006ThrHis: 1.006 ± 0.029	4.451ThrIle: 4.451 ± 0.058	3.774ThrLys: 3.774 ± 0.053	4.927ThrLeu: 4.927 ± 0.058	1.065ThrMet: 1.065 ± 0.029	3.373ThrAsn: 3.373 ± 0.064	2.414ThrPro: 2.414 ± 0.043	1.996ThrGln: 1.996 ± 0.042	1.901ThrArg: 1.901 ± 0.036	3.782ThrSer: 3.782 ± 0.064	4.393ThrThr: 4.393 ± 0.097	4.932ThrVal: 4.932 ± 0.089	0.842ThrTrp: 0.842 ± 0.026	2.297ThrTyr: 2.297 ± 0.041	0.0ThrXaa: 0.0 ± 0.0
Val	5.145ValAla: 5.145 ± 0.065	0.659ValCys: 0.659 ± 0.023	3.347ValAsp: 3.347 ± 0.052	3.67ValGlu: 3.67 ± 0.051	3.393ValPhe: 3.393 ± 0.052	3.757ValGly: 3.757 ± 0.059	1.152ValHis: 1.152 ± 0.029	4.336ValIle: 4.336 ± 0.059	4.871ValLys: 4.871 ± 0.06	6.336ValLeu: 6.336 ± 0.076	1.562ValMet: 1.562 ± 0.031	3.895ValAsn: 3.895 ± 0.063	2.485ValPro: 2.485 ± 0.039	2.619ValGln: 2.619 ± 0.043	2.476ValArg: 2.476 ± 0.045	4.353ValSer: 4.353 ± 0.068	4.48ValThr: 4.48 ± 0.085	4.801ValVal: 4.801 ± 0.07	0.89ValTrp: 0.89 ± 0.026	2.741ValTyr: 2.741 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	0.846TrpAla: 0.846 ± 0.026	0.117TrpCys: 0.117 ± 0.008	0.689TrpAsp: 0.689 ± 0.024	0.724TrpGlu: 0.724 ± 0.022	0.716TrpPhe: 0.716 ± 0.024	0.904TrpGly: 0.904 ± 0.025	0.31TrpHis: 0.31 ± 0.013	0.895TrpIle: 0.895 ± 0.028	1.109TrpLys: 1.109 ± 0.03	1.301TrpLeu: 1.301 ± 0.03	0.446TrpMet: 0.446 ± 0.018	0.92TrpAsn: 0.92 ± 0.024	0.361TrpPro: 0.361 ± 0.018	0.625TrpGln: 0.625 ± 0.022	0.57TrpArg: 0.57 ± 0.02	0.844TrpSer: 0.844 ± 0.028	0.733TrpThr: 0.733 ± 0.022	0.82TrpVal: 0.82 ± 0.026	0.252TrpTrp: 0.252 ± 0.013	0.57TrpTyr: 0.57 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.834TyrAla: 2.834 ± 0.049	0.402TyrCys: 0.402 ± 0.017	2.231TyrAsp: 2.231 ± 0.05	2.092TyrGlu: 2.092 ± 0.034	2.27TyrPhe: 2.27 ± 0.042	2.689TyrGly: 2.689 ± 0.045	0.799TyrHis: 0.799 ± 0.024	2.409TyrIle: 2.409 ± 0.038	2.848TyrLys: 2.848 ± 0.046	3.579TyrLeu: 3.579 ± 0.045	0.822TyrMet: 0.822 ± 0.023	2.72TyrAsn: 2.72 ± 0.052	1.65TyrPro: 1.65 ± 0.032	1.494TyrGln: 1.494 ± 0.036	1.941TyrArg: 1.941 ± 0.041	2.81TyrSer: 2.81 ± 0.054	2.508TyrThr: 2.508 ± 0.047	2.291TyrVal: 2.291 ± 0.031	0.581TyrTrp: 0.581 ± 0.022	2.052TyrTyr: 2.052 ± 0.045	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4180 proteins (1521579 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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