Amino acid dipepetide frequency for Congregibacter litoralis KT71

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	12.812AlaAla: 12.812 ± 0.133	1.117AlaCys: 1.117 ± 0.032	6.207AlaAsp: 6.207 ± 0.077	6.831AlaGlu: 6.831 ± 0.09	3.849AlaPhe: 3.849 ± 0.057	8.598AlaGly: 8.598 ± 0.097	1.854AlaHis: 1.854 ± 0.044	5.463AlaIle: 5.463 ± 0.068	3.246AlaLys: 3.246 ± 0.056	12.987AlaLeu: 12.987 ± 0.122	3.211AlaMet: 3.211 ± 0.059	2.827AlaAsn: 2.827 ± 0.048	4.485AlaPro: 4.485 ± 0.073	4.051AlaGln: 4.051 ± 0.057	6.905AlaArg: 6.905 ± 0.075	6.61AlaSer: 6.61 ± 0.075	5.429AlaThr: 5.429 ± 0.075	7.934AlaVal: 7.934 ± 0.094	1.372AlaTrp: 1.372 ± 0.039	2.541AlaTyr: 2.541 ± 0.048	0.0AlaXaa: 0.0 ± 0.0
Cys	1.061CysAla: 1.061 ± 0.034	0.17CysCys: 0.17 ± 0.012	0.628CysAsp: 0.628 ± 0.019	0.606CysGlu: 0.606 ± 0.022	0.359CysPhe: 0.359 ± 0.016	0.913CysGly: 0.913 ± 0.033	0.257CysHis: 0.257 ± 0.018	0.479CysIle: 0.479 ± 0.019	0.27CysLys: 0.27 ± 0.015	0.968CysLeu: 0.968 ± 0.03	0.179CysMet: 0.179 ± 0.012	0.28CysAsn: 0.28 ± 0.016	0.492CysPro: 0.492 ± 0.022	0.276CysGln: 0.276 ± 0.016	0.61CysArg: 0.61 ± 0.026	0.696CysSer: 0.696 ± 0.026	0.433CysThr: 0.433 ± 0.021	0.661CysVal: 0.661 ± 0.024	0.134CysTrp: 0.134 ± 0.011	0.226CysTyr: 0.226 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.77AspAla: 6.77 ± 0.082	0.585AspCys: 0.585 ± 0.028	3.868AspAsp: 3.868 ± 0.064	4.021AspGlu: 4.021 ± 0.055	2.376AspPhe: 2.376 ± 0.047	5.084AspGly: 5.084 ± 0.088	1.172AspHis: 1.172 ± 0.032	3.224AspIle: 3.224 ± 0.059	1.814AspLys: 1.814 ± 0.038	6.024AspLeu: 6.024 ± 0.07	1.403AspMet: 1.403 ± 0.034	1.823AspAsn: 1.823 ± 0.044	3.2AspPro: 3.2 ± 0.06	1.908AspGln: 1.908 ± 0.038	3.794AspArg: 3.794 ± 0.058	3.795AspSer: 3.795 ± 0.074	2.938AspThr: 2.938 ± 0.052	4.14AspVal: 4.14 ± 0.06	1.017AspTrp: 1.017 ± 0.031	2.051AspTyr: 2.051 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.089GluAla: 7.089 ± 0.091	0.463GluCys: 0.463 ± 0.02	3.597GluAsp: 3.597 ± 0.066	4.268GluGlu: 4.268 ± 0.069	2.162GluPhe: 2.162 ± 0.041	4.556GluGly: 4.556 ± 0.055	1.553GluHis: 1.553 ± 0.039	3.158GluIle: 3.158 ± 0.05	2.369GluLys: 2.369 ± 0.044	6.991GluLeu: 6.991 ± 0.078	1.369GluMet: 1.369 ± 0.031	2.0GluAsn: 2.0 ± 0.038	2.539GluPro: 2.539 ± 0.042	2.967GluGln: 2.967 ± 0.058	4.899GluArg: 4.899 ± 0.066	3.997GluSer: 3.997 ± 0.056	3.243GluThr: 3.243 ± 0.052	4.299GluVal: 4.299 ± 0.056	0.741GluTrp: 0.741 ± 0.02	1.513GluTyr: 1.513 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.024PheAla: 4.024 ± 0.061	0.426PheCys: 0.426 ± 0.018	2.604PheAsp: 2.604 ± 0.047	2.332PheGlu: 2.332 ± 0.037	1.574PhePhe: 1.574 ± 0.042	3.258PheGly: 3.258 ± 0.051	0.708PheHis: 0.708 ± 0.024	1.77PheIle: 1.77 ± 0.038	1.052PheLys: 1.052 ± 0.028	3.606PheLeu: 3.606 ± 0.066	0.887PheMet: 0.887 ± 0.027	1.198PheAsn: 1.198 ± 0.03	1.571PhePro: 1.571 ± 0.03	1.11PheGln: 1.11 ± 0.031	2.097PheArg: 2.097 ± 0.046	2.741PheSer: 2.741 ± 0.055	2.037PheThr: 2.037 ± 0.042	2.583PheVal: 2.583 ± 0.044	0.516PheTrp: 0.516 ± 0.021	1.14PheTyr: 1.14 ± 0.03	0.0PheXaa: 0.0 ± 0.0
Gly	7.685GlyAla: 7.685 ± 0.093	0.803GlyCys: 0.803 ± 0.026	5.008GlyAsp: 5.008 ± 0.075	5.284GlyGlu: 5.284 ± 0.06	3.503GlyPhe: 3.503 ± 0.06	6.456GlyGly: 6.456 ± 0.105	1.66GlyHis: 1.66 ± 0.046	4.32GlyIle: 4.32 ± 0.058	3.013GlyLys: 3.013 ± 0.053	8.226GlyLeu: 8.226 ± 0.092	2.157GlyMet: 2.157 ± 0.04	2.514GlyAsn: 2.514 ± 0.049	2.737GlyPro: 2.737 ± 0.054	2.704GlyGln: 2.704 ± 0.048	4.68GlyArg: 4.68 ± 0.066	5.234GlySer: 5.234 ± 0.081	3.997GlyThr: 3.997 ± 0.078	5.995GlyVal: 5.995 ± 0.08	1.159GlyTrp: 1.159 ± 0.036	2.266GlyTyr: 2.266 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	1.896HisAla: 1.896 ± 0.037	0.329HisCys: 0.329 ± 0.017	1.086HisAsp: 1.086 ± 0.028	1.137HisGlu: 1.137 ± 0.029	0.839HisPhe: 0.839 ± 0.025	1.791HisGly: 1.791 ± 0.034	0.617HisHis: 0.617 ± 0.023	1.058HisIle: 1.058 ± 0.032	0.578HisLys: 0.578 ± 0.021	2.074HisLeu: 2.074 ± 0.048	0.472HisMet: 0.472 ± 0.023	0.579HisAsn: 0.579 ± 0.019	1.276HisPro: 1.276 ± 0.031	0.704HisGln: 0.704 ± 0.023	1.65HisArg: 1.65 ± 0.035	1.3HisSer: 1.3 ± 0.033	0.921HisThr: 0.921 ± 0.027	1.223HisVal: 1.223 ± 0.029	0.4HisTrp: 0.4 ± 0.019	0.722HisTyr: 0.722 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	6.288IleAla: 6.288 ± 0.08	0.496IleCys: 0.496 ± 0.023	3.859IleAsp: 3.859 ± 0.063	3.469IleGlu: 3.469 ± 0.046	1.581IlePhe: 1.581 ± 0.039	3.983IleGly: 3.983 ± 0.061	0.935IleHis: 0.935 ± 0.024	2.148IleIle: 2.148 ± 0.045	1.541IleLys: 1.541 ± 0.038	3.962IleLeu: 3.962 ± 0.07	0.932IleMet: 0.932 ± 0.027	1.921IleAsn: 1.921 ± 0.041	2.336IlePro: 2.336 ± 0.043	1.449IleGln: 1.449 ± 0.036	2.986IleArg: 2.986 ± 0.048	3.204IleSer: 3.204 ± 0.053	2.847IleThr: 2.847 ± 0.054	3.589IleVal: 3.589 ± 0.064	0.532IleTrp: 0.532 ± 0.022	1.287IleTyr: 1.287 ± 0.034	0.0IleXaa: 0.0 ± 0.0
Lys	3.662LysAla: 3.662 ± 0.061	0.197LysCys: 0.197 ± 0.015	1.722LysAsp: 1.722 ± 0.04	1.799LysGlu: 1.799 ± 0.042	0.795LysPhe: 0.795 ± 0.024	2.204LysGly: 2.204 ± 0.052	0.745LysHis: 0.745 ± 0.025	1.483LysIle: 1.483 ± 0.042	1.33LysLys: 1.33 ± 0.041	3.194LysLeu: 3.194 ± 0.059	0.662LysMet: 0.662 ± 0.025	1.065LysAsn: 1.065 ± 0.034	1.774LysPro: 1.774 ± 0.041	1.293LysGln: 1.293 ± 0.033	2.288LysArg: 2.288 ± 0.043	1.994LysSer: 1.994 ± 0.036	1.929LysThr: 1.929 ± 0.047	2.175LysVal: 2.175 ± 0.043	0.311LysTrp: 0.311 ± 0.016	0.695LysTyr: 0.695 ± 0.026	0.0LysXaa: 0.0 ± 0.0
Leu	12.019LeuAla: 12.019 ± 0.114	1.151LeuCys: 1.151 ± 0.03	6.333LeuAsp: 6.333 ± 0.077	6.81LeuGlu: 6.81 ± 0.084	3.902LeuPhe: 3.902 ± 0.063	8.36LeuGly: 8.36 ± 0.085	2.152LeuHis: 2.152 ± 0.041	4.993LeuIle: 4.993 ± 0.074	3.497LeuLys: 3.497 ± 0.06	11.815LeuLeu: 11.815 ± 0.132	2.452LeuMet: 2.452 ± 0.051	3.128LeuAsn: 3.128 ± 0.054	5.49LeuPro: 5.49 ± 0.072	3.868LeuGln: 3.868 ± 0.059	7.806LeuArg: 7.806 ± 0.086	7.595LeuSer: 7.595 ± 0.097	5.38LeuThr: 5.38 ± 0.069	7.05LeuVal: 7.05 ± 0.092	1.382LeuTrp: 1.382 ± 0.03	2.444LeuTyr: 2.444 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.687MetAla: 2.687 ± 0.047	0.16MetCys: 0.16 ± 0.012	1.399MetAsp: 1.399 ± 0.035	1.33MetGlu: 1.33 ± 0.032	0.72MetPhe: 0.72 ± 0.025	1.789MetGly: 1.789 ± 0.04	0.525MetHis: 0.525 ± 0.02	1.139MetIle: 1.139 ± 0.03	0.831MetLys: 0.831 ± 0.027	2.676MetLeu: 2.676 ± 0.051	0.608MetMet: 0.608 ± 0.023	0.87MetAsn: 0.87 ± 0.024	1.301MetPro: 1.301 ± 0.028	0.957MetGln: 0.957 ± 0.027	1.557MetArg: 1.557 ± 0.038	1.846MetSer: 1.846 ± 0.037	1.469MetThr: 1.469 ± 0.035	1.56MetVal: 1.56 ± 0.035	0.185MetTrp: 0.185 ± 0.012	0.419MetTyr: 0.419 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.384AsnAla: 3.384 ± 0.055	0.311AsnCys: 0.311 ± 0.016	1.747AsnAsp: 1.747 ± 0.053	1.603AsnGlu: 1.603 ± 0.033	1.116AsnPhe: 1.116 ± 0.028	2.394AsnGly: 2.394 ± 0.057	0.645AsnHis: 0.645 ± 0.02	1.62AsnIle: 1.62 ± 0.037	0.844AsnLys: 0.844 ± 0.029	2.903AsnLeu: 2.903 ± 0.048	0.631AsnMet: 0.631 ± 0.023	0.957AsnAsn: 0.957 ± 0.033	2.073AsnPro: 2.073 ± 0.043	1.013AsnGln: 1.013 ± 0.028	2.065AsnArg: 2.065 ± 0.043	1.811AsnSer: 1.811 ± 0.037	1.673AsnThr: 1.673 ± 0.039	2.048AsnVal: 2.048 ± 0.049	0.488AsnTrp: 0.488 ± 0.022	0.931AsnTyr: 0.931 ± 0.028	0.0AsnXaa: 0.0 ± 0.0
Pro	4.876ProAla: 4.876 ± 0.073	0.38ProCys: 0.38 ± 0.019	3.224ProAsp: 3.224 ± 0.053	3.832ProGlu: 3.832 ± 0.058	1.658ProPhe: 1.658 ± 0.032	4.35ProGly: 4.35 ± 0.064	0.876ProHis: 0.876 ± 0.025	2.031ProIle: 2.031 ± 0.043	1.389ProLys: 1.389 ± 0.04	4.828ProLeu: 4.828 ± 0.072	1.204ProMet: 1.204 ± 0.033	1.277ProAsn: 1.277 ± 0.031	2.15ProPro: 2.15 ± 0.053	1.699ProGln: 1.699 ± 0.035	2.773ProArg: 2.773 ± 0.044	2.671ProSer: 2.671 ± 0.049	2.248ProThr: 2.248 ± 0.039	3.664ProVal: 3.664 ± 0.051	0.708ProTrp: 0.708 ± 0.024	1.143ProTyr: 1.143 ± 0.034	0.0ProXaa: 0.0 ± 0.0
Gln	4.056GlnAla: 4.056 ± 0.061	0.317GlnCys: 0.317 ± 0.016	1.677GlnAsp: 1.677 ± 0.04	2.086GlnGlu: 2.086 ± 0.042	1.277GlnPhe: 1.277 ± 0.033	2.684GlnGly: 2.684 ± 0.05	0.832GlnHis: 0.832 ± 0.025	1.749GlnIle: 1.749 ± 0.035	1.119GlnLys: 1.119 ± 0.031	4.227GlnLeu: 4.227 ± 0.066	0.866GlnMet: 0.866 ± 0.028	0.992GlnAsn: 0.992 ± 0.034	1.602GlnPro: 1.602 ± 0.035	1.734GlnGln: 1.734 ± 0.045	3.219GlnArg: 3.219 ± 0.051	2.415GlnSer: 2.415 ± 0.044	1.767GlnThr: 1.767 ± 0.038	2.442GlnVal: 2.442 ± 0.045	0.61GlnTrp: 0.61 ± 0.022	0.825GlnTyr: 0.825 ± 0.027	0.0GlnXaa: 0.0 ± 0.0
Arg	6.123ArgAla: 6.123 ± 0.07	0.676ArgCys: 0.676 ± 0.023	4.242ArgAsp: 4.242 ± 0.05	5.014ArgGlu: 5.014 ± 0.067	2.892ArgPhe: 2.892 ± 0.051	4.685ArgGly: 4.685 ± 0.065	1.543ArgHis: 1.543 ± 0.037	3.452ArgIle: 3.452 ± 0.054	2.226ArgLys: 2.226 ± 0.045	7.119ArgLeu: 7.119 ± 0.081	1.637ArgMet: 1.637 ± 0.039	2.016ArgAsn: 2.016 ± 0.036	2.634ArgPro: 2.634 ± 0.046	2.81ArgGln: 2.81 ± 0.045	4.925ArgArg: 4.925 ± 0.076	4.262ArgSer: 4.262 ± 0.06	2.624ArgThr: 2.624 ± 0.046	4.701ArgVal: 4.701 ± 0.069	1.132ArgTrp: 1.132 ± 0.031	2.2ArgTyr: 2.2 ± 0.044	0.0ArgXaa: 0.0 ± 0.0
Ser	6.829SerAla: 6.829 ± 0.075	0.621SerCys: 0.621 ± 0.023	4.058SerAsp: 4.058 ± 0.063	3.812SerGlu: 3.812 ± 0.063	2.533SerPhe: 2.533 ± 0.046	5.618SerGly: 5.618 ± 0.068	1.245SerHis: 1.245 ± 0.033	3.135SerIle: 3.135 ± 0.058	1.931SerLys: 1.931 ± 0.039	7.16SerLeu: 7.16 ± 0.084	1.655SerMet: 1.655 ± 0.035	1.878SerAsn: 1.878 ± 0.039	3.133SerPro: 3.133 ± 0.055	2.295SerGln: 2.295 ± 0.047	4.124SerArg: 4.124 ± 0.057	4.08SerSer: 4.08 ± 0.075	3.222SerThr: 3.222 ± 0.048	4.698SerVal: 4.698 ± 0.066	0.93SerTrp: 0.93 ± 0.032	1.807SerTyr: 1.807 ± 0.038	0.0SerXaa: 0.0 ± 0.0
Thr	5.657ThrAla: 5.657 ± 0.074	0.391ThrCys: 0.391 ± 0.018	2.927ThrAsp: 2.927 ± 0.058	2.81ThrGlu: 2.81 ± 0.044	1.574ThrPhe: 1.574 ± 0.037	4.457ThrGly: 4.457 ± 0.068	1.071ThrHis: 1.071 ± 0.028	2.466ThrIle: 2.466 ± 0.05	1.134ThrLys: 1.134 ± 0.036	6.467ThrLeu: 6.467 ± 0.073	1.064ThrMet: 1.064 ± 0.03	1.348ThrAsn: 1.348 ± 0.036	3.045ThrPro: 3.045 ± 0.057	1.76ThrGln: 1.76 ± 0.042	3.172ThrArg: 3.172 ± 0.059	2.821ThrSer: 2.821 ± 0.05	2.671ThrThr: 2.671 ± 0.052	4.302ThrVal: 4.302 ± 0.088	0.61ThrTrp: 0.61 ± 0.024	1.185ThrTyr: 1.185 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	7.755ValAla: 7.755 ± 0.086	0.655ValCys: 0.655 ± 0.022	4.547ValAsp: 4.547 ± 0.064	4.442ValGlu: 4.442 ± 0.073	2.878ValPhe: 2.878 ± 0.053	5.135ValGly: 5.135 ± 0.071	1.358ValHis: 1.358 ± 0.03	3.907ValIle: 3.907 ± 0.06	2.014ValLys: 2.014 ± 0.047	7.547ValLeu: 7.547 ± 0.09	1.79ValMet: 1.79 ± 0.039	2.366ValAsn: 2.366 ± 0.056	3.269ValPro: 3.269 ± 0.049	2.149ValGln: 2.149 ± 0.045	4.075ValArg: 4.075 ± 0.053	5.072ValSer: 5.072 ± 0.07	4.146ValThr: 4.146 ± 0.078	5.516ValVal: 5.516 ± 0.082	0.805ValTrp: 0.805 ± 0.026	1.8ValTyr: 1.8 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.035TrpAla: 1.035 ± 0.029	0.157TrpCys: 0.157 ± 0.013	0.727TrpAsp: 0.727 ± 0.022	0.744TrpGlu: 0.744 ± 0.026	0.519TrpPhe: 0.519 ± 0.02	0.878TrpGly: 0.878 ± 0.03	0.334TrpHis: 0.334 ± 0.019	0.673TrpIle: 0.673 ± 0.023	0.402TrpLys: 0.402 ± 0.018	1.798TrpLeu: 1.798 ± 0.04	0.373TrpMet: 0.373 ± 0.017	0.437TrpAsn: 0.437 ± 0.021	0.561TrpPro: 0.561 ± 0.022	0.711TrpGln: 0.711 ± 0.024	1.085TrpArg: 1.085 ± 0.03	0.955TrpSer: 0.955 ± 0.027	0.678TrpThr: 0.678 ± 0.028	0.97TrpVal: 0.97 ± 0.027	0.209TrpTrp: 0.209 ± 0.013	0.393TrpTyr: 0.393 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.618TyrAla: 2.618 ± 0.052	0.294TyrCys: 0.294 ± 0.015	1.547TyrAsp: 1.547 ± 0.039	1.541TyrGlu: 1.541 ± 0.033	1.129TyrPhe: 1.129 ± 0.033	2.205TyrGly: 2.205 ± 0.044	0.568TyrHis: 0.568 ± 0.022	1.077TyrIle: 1.077 ± 0.028	0.717TyrLys: 0.717 ± 0.023	3.055TyrLeu: 3.055 ± 0.054	0.477TyrMet: 0.477 ± 0.019	0.784TyrAsn: 0.784 ± 0.033	1.312TyrPro: 1.312 ± 0.038	1.038TyrGln: 1.038 ± 0.03	2.203TyrArg: 2.203 ± 0.045	1.667TyrSer: 1.667 ± 0.041	1.282TyrThr: 1.282 ± 0.034	1.676TyrVal: 1.676 ± 0.037	0.397TyrTrp: 0.397 ± 0.016	0.795TyrTyr: 0.795 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3868 proteins (1301601 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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