Amino acid dipepetide frequency for Sanxia tombus-like virus 4

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.732AlaAla: 10.732 ± 4.117
0.976AlaCys: 0.976 ± 1.223
4.878AlaAsp: 4.878 ± 0.447
3.902AlaGlu: 3.902 ± 1.052
3.902AlaPhe: 3.902 ± 1.264
9.756AlaGly: 9.756 ± 4.362
0.976AlaHis: 0.976 ± 0.75
2.927AlaIle: 2.927 ± 1.224
2.927AlaLys: 2.927 ± 1.041
1.951AlaLeu: 1.951 ± 0.957
0.0AlaMet: 0.0 ± 0.0
2.927AlaAsn: 2.927 ± 1.224
1.951AlaPro: 1.951 ± 1.499
0.976AlaGln: 0.976 ± 0.75
6.829AlaArg: 6.829 ± 1.596
2.927AlaSer: 2.927 ± 1.041
2.927AlaThr: 2.927 ± 2.38
8.78AlaVal: 8.78 ± 3.33
2.927AlaTrp: 2.927 ± 0.67
2.927AlaTyr: 2.927 ± 0.67
0.0AlaXaa: 0.0 ± 0.0
Cys
1.951CysAla: 1.951 ± 1.499
0.0CysCys: 0.0 ± 0.0
2.927CysAsp: 2.927 ± 1.087
0.976CysGlu: 0.976 ± 0.75
0.0CysPhe: 0.0 ± 0.0
0.976CysGly: 0.976 ± 0.651
0.976CysHis: 0.976 ± 1.223
3.902CysIle: 3.902 ± 2.604
0.0CysLys: 0.0 ± 0.0
0.0CysLeu: 0.0 ± 0.0
0.0CysMet: 0.0 ± 0.0
0.0CysAsn: 0.0 ± 0.0
0.976CysPro: 0.976 ± 0.651
1.951CysGln: 1.951 ± 1.302
2.927CysArg: 2.927 ± 2.097
1.951CysSer: 1.951 ± 0.632
0.0CysThr: 0.0 ± 0.0
2.927CysVal: 2.927 ± 1.224
0.0CysTrp: 0.0 ± 0.0
0.976CysTyr: 0.976 ± 0.651
0.0CysXaa: 0.0 ± 0.0
Asp
3.902AspAla: 3.902 ± 0.359
1.951AspCys: 1.951 ± 0.632
4.878AspAsp: 4.878 ± 2.063
1.951AspGlu: 1.951 ± 1.302
3.902AspPhe: 3.902 ± 1.913
5.854AspGly: 5.854 ± 2.658
0.0AspHis: 0.0 ± 0.0
2.927AspIle: 2.927 ± 2.097
0.976AspLys: 0.976 ± 0.651
3.902AspLeu: 3.902 ± 1.618
0.976AspMet: 0.976 ± 0.651
2.927AspAsn: 2.927 ± 1.087
0.0AspPro: 0.0 ± 0.0
3.902AspGln: 3.902 ± 0.359
2.927AspArg: 2.927 ± 1.041
1.951AspSer: 1.951 ± 0.957
3.902AspThr: 3.902 ± 1.929
4.878AspVal: 4.878 ± 1.941
0.976AspTrp: 0.976 ± 0.75
2.927AspTyr: 2.927 ± 1.041
0.0AspXaa: 0.0 ± 0.0
Glu
3.902GluAla: 3.902 ± 1.052
0.976GluCys: 0.976 ± 1.223
2.927GluAsp: 2.927 ± 2.097
3.902GluGlu: 3.902 ± 1.913
2.927GluPhe: 2.927 ± 1.087
4.878GluGly: 4.878 ± 1.925
3.902GluHis: 3.902 ± 1.913
1.951GluIle: 1.951 ± 0.632
4.878GluLys: 4.878 ± 1.472
2.927GluLeu: 2.927 ± 1.087
2.927GluMet: 2.927 ± 1.953
2.927GluAsn: 2.927 ± 0.67
0.976GluPro: 0.976 ± 0.651
2.927GluGln: 2.927 ± 1.041
5.854GluArg: 5.854 ± 2.658
3.902GluSer: 3.902 ± 1.618
0.976GluThr: 0.976 ± 1.223
1.951GluVal: 1.951 ± 1.272
0.976GluTrp: 0.976 ± 0.75
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
2.927PheAla: 2.927 ± 1.224
2.927PheCys: 2.927 ± 1.953
2.927PheAsp: 2.927 ± 1.041
2.927PheGlu: 2.927 ± 1.087
1.951PhePhe: 1.951 ± 2.446
4.878PheGly: 4.878 ± 0.447
1.951PheHis: 1.951 ± 1.499
0.976PheIle: 0.976 ± 0.651
0.976PheLys: 0.976 ± 1.223
2.927PheLeu: 2.927 ± 0.67
0.976PheMet: 0.976 ± 0.75
1.951PheAsn: 1.951 ± 0.957
0.976PhePro: 0.976 ± 1.223
0.0PheGln: 0.0 ± 0.0
1.951PheArg: 1.951 ± 1.302
1.951PheSer: 1.951 ± 0.632
3.902PheThr: 3.902 ± 0.359
1.951PheVal: 1.951 ± 0.957
0.0PheTrp: 0.0 ± 0.0
2.927PheTyr: 2.927 ± 2.38
0.0PheXaa: 0.0 ± 0.0
Gly
9.756GlyAla: 9.756 ± 1.494
1.951GlyCys: 1.951 ± 0.632
5.854GlyAsp: 5.854 ± 2.174
3.902GlyGlu: 3.902 ± 1.052
4.878GlyPhe: 4.878 ± 0.81
3.902GlyGly: 3.902 ± 2.543
0.0GlyHis: 0.0 ± 0.0
5.854GlyIle: 5.854 ± 1.895
6.829GlyLys: 6.829 ± 1.596
6.829GlyLeu: 6.829 ± 2.191
1.951GlyMet: 1.951 ± 0.926
2.927GlyAsn: 2.927 ± 1.224
0.976GlyPro: 0.976 ± 0.75
3.902GlyGln: 3.902 ± 1.618
6.829GlyArg: 6.829 ± 2.642
6.829GlySer: 6.829 ± 2.741
6.829GlyThr: 6.829 ± 1.596
6.829GlyVal: 6.829 ± 1.596
0.976GlyTrp: 0.976 ± 0.75
1.951GlyTyr: 1.951 ± 0.632
0.0GlyXaa: 0.0 ± 0.0
His
0.976HisAla: 0.976 ± 0.75
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.976HisGlu: 0.976 ± 0.75
0.976HisPhe: 0.976 ± 1.223
2.927HisGly: 2.927 ± 0.67
0.0HisHis: 0.0 ± 0.0
0.976HisIle: 0.976 ± 1.223
1.951HisLys: 1.951 ± 0.632
1.951HisLeu: 1.951 ± 0.632
0.0HisMet: 0.0 ± 0.0
0.976HisAsn: 0.976 ± 0.651
3.902HisPro: 3.902 ± 1.264
1.951HisGln: 1.951 ± 0.632
0.0HisArg: 0.0 ± 0.0
1.951HisSer: 1.951 ± 1.499
0.0HisThr: 0.0 ± 0.0
1.951HisVal: 1.951 ± 1.272
0.0HisTrp: 0.0 ± 0.0
0.976HisTyr: 0.976 ± 1.223
0.0HisXaa: 0.0 ± 0.0
Ile
5.854IleAla: 5.854 ± 0.375
0.0IleCys: 0.0 ± 0.0
4.878IleAsp: 4.878 ± 0.81
0.976IleGlu: 0.976 ± 0.651
2.927IlePhe: 2.927 ± 1.041
3.902IleGly: 3.902 ± 1.618
0.976IleHis: 0.976 ± 0.75
2.927IleIle: 2.927 ± 1.953
1.951IleLys: 1.951 ± 0.957
1.951IleLeu: 1.951 ± 0.957
2.927IleMet: 2.927 ± 1.673
2.927IleAsn: 2.927 ± 1.041
1.951IlePro: 1.951 ± 1.499
0.0IleGln: 0.0 ± 0.0
3.902IleArg: 3.902 ± 0.359
1.951IleSer: 1.951 ± 1.302
2.927IleThr: 2.927 ± 1.224
3.902IleVal: 3.902 ± 1.929
0.0IleTrp: 0.0 ± 0.0
2.927IleTyr: 2.927 ± 2.38
0.0IleXaa: 0.0 ± 0.0
Lys
3.902LysAla: 3.902 ± 2.998
2.927LysCys: 2.927 ± 1.953
0.0LysAsp: 0.0 ± 0.0
0.976LysGlu: 0.976 ± 0.651
1.951LysPhe: 1.951 ± 2.446
3.902LysGly: 3.902 ± 1.913
0.976LysHis: 0.976 ± 0.651
2.927LysIle: 2.927 ± 2.38
4.878LysLys: 4.878 ± 4.51
6.829LysLeu: 6.829 ± 2.191
0.976LysMet: 0.976 ± 0.651
2.927LysAsn: 2.927 ± 2.38
1.951LysPro: 1.951 ± 1.302
0.0LysGln: 0.0 ± 0.0
1.951LysArg: 1.951 ± 1.272
1.951LysSer: 1.951 ± 1.272
2.927LysThr: 2.927 ± 1.087
5.854LysVal: 5.854 ± 1.299
1.951LysTrp: 1.951 ± 0.632
1.951LysTyr: 1.951 ± 0.957
0.0LysXaa: 0.0 ± 0.0
Leu
6.829LeuAla: 6.829 ± 2.063
0.0LeuCys: 0.0 ± 0.0
9.756LeuAsp: 9.756 ± 2.895
5.854LeuGlu: 5.854 ± 2.868
2.927LeuPhe: 2.927 ± 1.041
2.927LeuGly: 2.927 ± 1.087
2.927LeuHis: 2.927 ± 2.249
2.927LeuIle: 2.927 ± 0.67
6.829LeuLys: 6.829 ± 3.275
10.732LeuLeu: 10.732 ± 4.65
0.976LeuMet: 0.976 ± 0.656
3.902LeuAsn: 3.902 ± 0.359
0.0LeuPro: 0.0 ± 0.0
4.878LeuGln: 4.878 ± 3.255
2.927LeuArg: 2.927 ± 1.953
4.878LeuSer: 4.878 ± 2.658
4.878LeuThr: 4.878 ± 0.81
4.878LeuVal: 4.878 ± 1.699
0.0LeuTrp: 0.0 ± 0.0
0.0LeuTyr: 0.0 ± 0.0
0.0LeuXaa: 0.0 ± 0.0
Met
0.0MetAla: 0.0 ± 0.0
0.976MetCys: 0.976 ± 1.223
1.951MetAsp: 1.951 ± 0.957
0.976MetGlu: 0.976 ± 0.651
0.0MetPhe: 0.0 ± 0.0
0.0MetGly: 0.0 ± 0.0
0.0MetHis: 0.0 ± 0.0
0.976MetIle: 0.976 ± 1.223
0.976MetLys: 0.976 ± 0.651
3.902MetLeu: 3.902 ± 1.618
0.976MetMet: 0.976 ± 1.223
1.951MetAsn: 1.951 ± 0.632
0.0MetPro: 0.0 ± 0.0
0.0MetGln: 0.0 ± 0.0
4.878MetArg: 4.878 ± 3.615
0.0MetSer: 0.0 ± 0.0
1.951MetThr: 1.951 ± 1.302
0.976MetVal: 0.976 ± 0.75
0.0MetTrp: 0.0 ± 0.0
1.951MetTyr: 1.951 ± 1.302
0.0MetXaa: 0.0 ± 0.0
Asn
3.902AsnAla: 3.902 ± 1.868
0.976AsnCys: 0.976 ± 0.651
2.927AsnAsp: 2.927 ± 1.087
1.951AsnGlu: 1.951 ± 0.957
1.951AsnPhe: 1.951 ± 1.272
2.927AsnGly: 2.927 ± 1.041
1.951AsnHis: 1.951 ± 1.499
2.927AsnIle: 2.927 ± 1.224
1.951AsnLys: 1.951 ± 0.632
1.951AsnLeu: 1.951 ± 0.632
0.976AsnMet: 0.976 ± 1.223
0.976AsnAsn: 0.976 ± 1.223
4.878AsnPro: 4.878 ± 1.595
0.0AsnGln: 0.0 ± 0.0
1.951AsnArg: 1.951 ± 1.272
0.976AsnSer: 0.976 ± 0.651
4.878AsnThr: 4.878 ± 1.798
6.829AsnVal: 6.829 ± 2.401
0.0AsnTrp: 0.0 ± 0.0
0.976AsnTyr: 0.976 ± 1.223
0.0AsnXaa: 0.0 ± 0.0
Pro
1.951ProAla: 1.951 ± 0.632
0.0ProCys: 0.0 ± 0.0
0.0ProAsp: 0.0 ± 0.0
1.951ProGlu: 1.951 ± 0.957
0.976ProPhe: 0.976 ± 0.651
4.878ProGly: 4.878 ± 2.658
1.951ProHis: 1.951 ± 0.632
2.927ProIle: 2.927 ± 1.041
0.976ProLys: 0.976 ± 1.223
1.951ProLeu: 1.951 ± 0.632
0.0ProMet: 0.0 ± 0.0
2.927ProAsn: 2.927 ± 1.224
0.976ProPro: 0.976 ± 1.223
2.927ProGln: 2.927 ± 1.953
4.878ProArg: 4.878 ± 0.447
3.902ProSer: 3.902 ± 1.929
1.951ProThr: 1.951 ± 0.632
4.878ProVal: 4.878 ± 2.235
0.0ProTrp: 0.0 ± 0.0
0.0ProTyr: 0.0 ± 0.0
0.0ProXaa: 0.0 ± 0.0
Gln
1.951GlnAla: 1.951 ± 1.302
0.976GlnCys: 0.976 ± 0.651
1.951GlnAsp: 1.951 ± 0.632
1.951GlnGlu: 1.951 ± 1.302
0.976GlnPhe: 0.976 ± 0.651
0.976GlnGly: 0.976 ± 0.75
0.976GlnHis: 0.976 ± 0.651
1.951GlnIle: 1.951 ± 1.302
0.0GlnLys: 0.0 ± 0.0
3.902GlnLeu: 3.902 ± 1.618
0.0GlnMet: 0.0 ± 0.0
0.976GlnAsn: 0.976 ± 0.651
1.951GlnPro: 1.951 ± 1.302
0.976GlnGln: 0.976 ± 0.651
1.951GlnArg: 1.951 ± 0.632
1.951GlnSer: 1.951 ± 1.302
1.951GlnThr: 1.951 ± 1.499
1.951GlnVal: 1.951 ± 1.272
1.951GlnTrp: 1.951 ± 1.302
0.976GlnTyr: 0.976 ± 0.651
0.0GlnXaa: 0.0 ± 0.0
Arg
4.878ArgAla: 4.878 ± 1.595
0.976ArgCys: 0.976 ± 0.651
2.927ArgAsp: 2.927 ± 1.953
7.805ArgGlu: 7.805 ± 3.737
2.927ArgPhe: 2.927 ± 0.67
6.829ArgGly: 6.829 ± 2.401
1.951ArgHis: 1.951 ± 1.272
1.951ArgIle: 1.951 ± 1.302
3.902ArgLys: 3.902 ± 1.868
6.829ArgLeu: 6.829 ± 0.855
2.927ArgMet: 2.927 ± 1.087
2.927ArgAsn: 2.927 ± 1.041
4.878ArgPro: 4.878 ± 0.81
0.976ArgGln: 0.976 ± 0.651
8.78ArgArg: 8.78 ± 3.016
3.902ArgSer: 3.902 ± 1.515
0.976ArgThr: 0.976 ± 0.651
5.854ArgVal: 5.854 ± 1.299
0.0ArgTrp: 0.0 ± 0.0
4.878ArgTyr: 4.878 ± 0.81
0.0ArgXaa: 0.0 ± 0.0
Ser
2.927SerAla: 2.927 ± 1.691
0.0SerCys: 0.0 ± 0.0
1.951SerAsp: 1.951 ± 1.499
4.878SerGlu: 4.878 ± 1.472
1.951SerPhe: 1.951 ± 0.632
9.756SerGly: 9.756 ± 0.374
0.976SerHis: 0.976 ± 0.651
1.951SerIle: 1.951 ± 0.632
0.0SerLys: 0.0 ± 0.0
5.854SerLeu: 5.854 ± 1.895
0.0SerMet: 0.0 ± 0.0
3.902SerAsn: 3.902 ± 1.929
2.927SerPro: 2.927 ± 1.041
0.0SerGln: 0.0 ± 0.0
3.902SerArg: 3.902 ± 1.515
0.976SerSer: 0.976 ± 0.651
3.902SerThr: 3.902 ± 2.998
3.902SerVal: 3.902 ± 1.618
0.0SerTrp: 0.0 ± 0.0
1.951SerTyr: 1.951 ± 0.632
0.0SerXaa: 0.0 ± 0.0
Thr
4.878ThrAla: 4.878 ± 2.897
0.976ThrCys: 0.976 ± 0.75
1.951ThrAsp: 1.951 ± 1.302
1.951ThrGlu: 1.951 ± 0.957
1.951ThrPhe: 1.951 ± 0.632
4.878ThrGly: 4.878 ± 1.699
0.0ThrHis: 0.0 ± 0.0
2.927ThrIle: 2.927 ± 2.249
3.902ThrLys: 3.902 ± 3.298
1.951ThrLeu: 1.951 ± 1.302
1.951ThrMet: 1.951 ± 1.499
3.902ThrAsn: 3.902 ± 2.287
1.951ThrPro: 1.951 ± 1.302
1.951ThrGln: 1.951 ± 0.632
4.878ThrArg: 4.878 ± 2.235
3.902ThrSer: 3.902 ± 1.264
5.854ThrThr: 5.854 ± 1.181
4.878ThrVal: 4.878 ± 1.925
0.0ThrTrp: 0.0 ± 0.0
0.976ThrTyr: 0.976 ± 0.75
0.0ThrXaa: 0.0 ± 0.0
Val
2.927ValAla: 2.927 ± 1.691
6.829ValCys: 6.829 ± 0.865
1.951ValAsp: 1.951 ± 0.632
5.854ValGlu: 5.854 ± 4.195
1.951ValPhe: 1.951 ± 0.632
10.732ValGly: 10.732 ± 2.853
0.976ValHis: 0.976 ± 0.651
2.927ValIle: 2.927 ± 2.097
6.829ValLys: 6.829 ± 3.142
6.829ValLeu: 6.829 ± 2.063
0.976ValMet: 0.976 ± 0.651
1.951ValAsn: 1.951 ± 1.302
7.805ValPro: 7.805 ± 2.675
1.951ValGln: 1.951 ± 0.632
7.805ValArg: 7.805 ± 0.717
3.902ValSer: 3.902 ± 1.052
1.951ValThr: 1.951 ± 2.446
5.854ValVal: 5.854 ± 2.87
1.951ValTrp: 1.951 ± 2.446
1.951ValTyr: 1.951 ± 1.302
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
0.0TrpCys: 0.0 ± 0.0
0.976TrpAsp: 0.976 ± 1.223
0.976TrpGlu: 0.976 ± 0.651
1.951TrpPhe: 1.951 ± 1.272
0.976TrpGly: 0.976 ± 0.651
0.0TrpHis: 0.0 ± 0.0
0.0TrpIle: 0.0 ± 0.0
0.976TrpLys: 0.976 ± 1.223
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.0TrpSer: 0.0 ± 0.0
0.0TrpThr: 0.0 ± 0.0
2.927TrpVal: 2.927 ± 2.249
0.0TrpTrp: 0.0 ± 0.0
2.927TrpTyr: 2.927 ± 1.041
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.951TyrAla: 1.951 ± 1.272
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
1.951TyrGlu: 1.951 ± 0.632
0.976TyrPhe: 0.976 ± 0.75
4.878TyrGly: 4.878 ± 3.022
0.976TyrHis: 0.976 ± 1.223
2.927TyrIle: 2.927 ± 1.041
0.0TyrLys: 0.0 ± 0.0
5.854TyrLeu: 5.854 ± 2.658
1.951TyrMet: 1.951 ± 0.957
1.951TyrAsn: 1.951 ± 1.272
0.976TyrPro: 0.976 ± 0.75
0.976TyrGln: 0.976 ± 0.651
1.951TyrArg: 1.951 ± 0.957
1.951TyrSer: 1.951 ± 0.632
2.927TyrThr: 2.927 ± 1.224
1.951TyrVal: 1.951 ± 1.302
0.0TyrTrp: 0.0 ± 0.0
0.976TyrTyr: 0.976 ± 0.75
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3 proteins (1026 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski