Amino acid dipepetide frequency for Salinicoccus alkaliphilus DSM 16010

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.339AlaAla: 6.339 ± 0.119	0.491AlaCys: 0.491 ± 0.028	4.175AlaAsp: 4.175 ± 0.094	5.569AlaGlu: 5.569 ± 0.102	3.361AlaPhe: 3.361 ± 0.077	6.604AlaGly: 6.604 ± 0.108	1.544AlaHis: 1.544 ± 0.047	5.028AlaIle: 5.028 ± 0.099	3.511AlaLys: 3.511 ± 0.07	7.833AlaLeu: 7.833 ± 0.118	2.224AlaMet: 2.224 ± 0.056	2.292AlaAsn: 2.292 ± 0.048	2.33AlaPro: 2.33 ± 0.054	2.002AlaGln: 2.002 ± 0.052	3.095AlaArg: 3.095 ± 0.073	4.149AlaSer: 4.149 ± 0.078	3.341AlaThr: 3.341 ± 0.071	6.268AlaVal: 6.268 ± 0.102	0.546AlaTrp: 0.546 ± 0.027	2.302AlaTyr: 2.302 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.344CysAla: 0.344 ± 0.025	0.048CysCys: 0.048 ± 0.009	0.324CysAsp: 0.324 ± 0.023	0.327CysGlu: 0.327 ± 0.024	0.189CysPhe: 0.189 ± 0.015	0.629CysGly: 0.629 ± 0.029	0.175CysHis: 0.175 ± 0.017	0.365CysIle: 0.365 ± 0.026	0.2CysLys: 0.2 ± 0.018	0.437CysLeu: 0.437 ± 0.024	0.101CysMet: 0.101 ± 0.012	0.223CysAsn: 0.223 ± 0.02	0.291CysPro: 0.291 ± 0.02	0.121CysGln: 0.121 ± 0.015	0.299CysArg: 0.299 ± 0.02	0.333CysSer: 0.333 ± 0.021	0.325CysThr: 0.325 ± 0.024	0.281CysVal: 0.281 ± 0.021	0.032CysTrp: 0.032 ± 0.006	0.186CysTyr: 0.186 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	4.556AspAla: 4.556 ± 0.081	0.283AspCys: 0.283 ± 0.019	4.201AspAsp: 4.201 ± 0.099	6.38AspGlu: 6.38 ± 0.13	2.962AspPhe: 2.962 ± 0.074	4.468AspGly: 4.468 ± 0.092	1.527AspHis: 1.527 ± 0.05	5.246AspIle: 5.246 ± 0.088	3.282AspLys: 3.282 ± 0.076	5.292AspLeu: 5.292 ± 0.079	1.913AspMet: 1.913 ± 0.051	2.094AspAsn: 2.094 ± 0.054	2.142AspPro: 2.142 ± 0.062	1.608AspGln: 1.608 ± 0.051	2.674AspArg: 2.674 ± 0.062	2.937AspSer: 2.937 ± 0.079	3.079AspThr: 3.079 ± 0.075	4.575AspVal: 4.575 ± 0.095	0.532AspTrp: 0.532 ± 0.025	2.656AspTyr: 2.656 ± 0.06	0.0AspXaa: 0.0 ± 0.0
Glu	6.831GluAla: 6.831 ± 0.115	0.311GluCys: 0.311 ± 0.019	5.737GluAsp: 5.737 ± 0.158	8.479GluGlu: 8.479 ± 0.199	2.662GluPhe: 2.662 ± 0.063	5.291GluGly: 5.291 ± 0.096	1.65GluHis: 1.65 ± 0.053	5.894GluIle: 5.894 ± 0.073	5.465GluLys: 5.465 ± 0.113	6.643GluLeu: 6.643 ± 0.096	2.81GluMet: 2.81 ± 0.062	3.991GluAsn: 3.991 ± 0.087	2.124GluPro: 2.124 ± 0.068	2.451GluGln: 2.451 ± 0.066	3.862GluArg: 3.862 ± 0.077	4.188GluSer: 4.188 ± 0.093	4.411GluThr: 4.411 ± 0.07	6.006GluVal: 6.006 ± 0.116	0.75GluTrp: 0.75 ± 0.027	2.883GluTyr: 2.883 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	2.804PheAla: 2.804 ± 0.066	0.247PheCys: 0.247 ± 0.017	2.779PheAsp: 2.779 ± 0.06	3.209PheGlu: 3.209 ± 0.076	2.089PhePhe: 2.089 ± 0.069	3.447PheGly: 3.447 ± 0.077	1.025PheHis: 1.025 ± 0.036	3.979PheIle: 3.979 ± 0.095	2.743PheLys: 2.743 ± 0.058	4.132PheLeu: 4.132 ± 0.089	1.299PheMet: 1.299 ± 0.044	2.151PheAsn: 2.151 ± 0.053	1.415PhePro: 1.415 ± 0.04	1.183PheGln: 1.183 ± 0.037	1.753PheArg: 1.753 ± 0.054	2.888PheSer: 2.888 ± 0.064	2.648PheThr: 2.648 ± 0.055	2.921PheVal: 2.921 ± 0.071	0.369PheTrp: 0.369 ± 0.024	1.531PheTyr: 1.531 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.765GlyAla: 5.765 ± 0.109	0.459GlyCys: 0.459 ± 0.027	4.159GlyAsp: 4.159 ± 0.071	5.553GlyGlu: 5.553 ± 0.093	3.499GlyPhe: 3.499 ± 0.068	5.765GlyGly: 5.765 ± 0.119	1.782GlyHis: 1.782 ± 0.048	5.891GlyIle: 5.891 ± 0.09	3.884GlyLys: 3.884 ± 0.079	6.782GlyLeu: 6.782 ± 0.112	2.44GlyMet: 2.44 ± 0.064	2.632GlyAsn: 2.632 ± 0.057	2.014GlyPro: 2.014 ± 0.047	2.038GlyGln: 2.038 ± 0.051	3.631GlyArg: 3.631 ± 0.07	4.12GlySer: 4.12 ± 0.086	4.375GlyThr: 4.375 ± 0.081	5.62GlyVal: 5.62 ± 0.102	0.694GlyTrp: 0.694 ± 0.035	2.952GlyTyr: 2.952 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.51HisAla: 1.51 ± 0.041	0.123HisCys: 0.123 ± 0.014	1.422HisAsp: 1.422 ± 0.046	1.769HisGlu: 1.769 ± 0.059	1.129HisPhe: 1.129 ± 0.035	1.68HisGly: 1.68 ± 0.052	0.863HisHis: 0.863 ± 0.037	1.633HisIle: 1.633 ± 0.048	1.009HisLys: 1.009 ± 0.036	2.399HisLeu: 2.399 ± 0.066	0.676HisMet: 0.676 ± 0.033	0.789HisAsn: 0.789 ± 0.028	1.34HisPro: 1.34 ± 0.047	0.762HisGln: 0.762 ± 0.035	1.04HisArg: 1.04 ± 0.045	1.206HisSer: 1.206 ± 0.044	1.212HisThr: 1.212 ± 0.042	1.484HisVal: 1.484 ± 0.045	0.199HisTrp: 0.199 ± 0.016	0.884HisTyr: 0.884 ± 0.041	0.0HisXaa: 0.0 ± 0.0
Ile	5.543IleAla: 5.543 ± 0.1	0.462IleCys: 0.462 ± 0.025	4.862IleAsp: 4.862 ± 0.078	5.84IleGlu: 5.84 ± 0.096	3.501IlePhe: 3.501 ± 0.083	5.927IleGly: 5.927 ± 0.106	1.677IleHis: 1.677 ± 0.048	6.586IleIle: 6.586 ± 0.124	3.963IleLys: 3.963 ± 0.086	6.863IleLeu: 6.863 ± 0.119	2.147IleMet: 2.147 ± 0.063	3.379IleAsn: 3.379 ± 0.072	3.063IlePro: 3.063 ± 0.069	2.09IleGln: 2.09 ± 0.056	3.273IleArg: 3.273 ± 0.069	4.857IleSer: 4.857 ± 0.08	4.484IleThr: 4.484 ± 0.073	5.25IleVal: 5.25 ± 0.09	0.588IleTrp: 0.588 ± 0.027	2.525IleTyr: 2.525 ± 0.061	0.0IleXaa: 0.0 ± 0.0
Lys	3.943LysAla: 3.943 ± 0.084	0.226LysCys: 0.226 ± 0.017	3.813LysAsp: 3.813 ± 0.075	5.362LysGlu: 5.362 ± 0.102	2.038LysPhe: 2.038 ± 0.051	3.708LysGly: 3.708 ± 0.068	1.268LysHis: 1.268 ± 0.041	3.808LysIle: 3.808 ± 0.078	4.218LysLys: 4.218 ± 0.094	4.56LysLeu: 4.56 ± 0.081	1.968LysMet: 1.968 ± 0.054	2.783LysAsn: 2.783 ± 0.07	1.753LysPro: 1.753 ± 0.055	1.694LysGln: 1.694 ± 0.049	2.981LysArg: 2.981 ± 0.071	3.296LysSer: 3.296 ± 0.064	2.875LysThr: 2.875 ± 0.062	4.402LysVal: 4.402 ± 0.076	0.475LysTrp: 0.475 ± 0.024	2.223LysTyr: 2.223 ± 0.058	0.0LysXaa: 0.0 ± 0.0
Leu	6.579LeuAla: 6.579 ± 0.106	0.465LeuCys: 0.465 ± 0.026	5.581LeuAsp: 5.581 ± 0.083	7.134LeuGlu: 7.134 ± 0.112	4.186LeuPhe: 4.186 ± 0.092	6.603LeuGly: 6.603 ± 0.093	1.794LeuHis: 1.794 ± 0.054	7.256LeuIle: 7.256 ± 0.12	6.047LeuLys: 6.047 ± 0.108	8.794LeuLeu: 8.794 ± 0.157	2.99LeuMet: 2.99 ± 0.071	4.197LeuAsn: 4.197 ± 0.075	3.573LeuPro: 3.573 ± 0.073	2.507LeuGln: 2.507 ± 0.059	3.549LeuArg: 3.549 ± 0.076	6.355LeuSer: 6.355 ± 0.114	5.315LeuThr: 5.315 ± 0.087	5.866LeuVal: 5.866 ± 0.103	0.681LeuTrp: 0.681 ± 0.03	3.106LeuTyr: 3.106 ± 0.069	0.0LeuXaa: 0.0 ± 0.0
Met	2.289MetAla: 2.289 ± 0.057	0.123MetCys: 0.123 ± 0.012	1.931MetAsp: 1.931 ± 0.051	2.33MetGlu: 2.33 ± 0.051	1.249MetPhe: 1.249 ± 0.048	1.966MetGly: 1.966 ± 0.059	0.609MetHis: 0.609 ± 0.03	2.409MetIle: 2.409 ± 0.049	2.401MetLys: 2.401 ± 0.052	2.855MetLeu: 2.855 ± 0.068	1.214MetMet: 1.214 ± 0.042	1.656MetAsn: 1.656 ± 0.044	1.154MetPro: 1.154 ± 0.037	0.914MetGln: 0.914 ± 0.037	1.236MetArg: 1.236 ± 0.042	1.885MetSer: 1.885 ± 0.046	2.046MetThr: 2.046 ± 0.051	1.968MetVal: 1.968 ± 0.053	0.175MetTrp: 0.175 ± 0.015	0.927MetTyr: 0.927 ± 0.034	0.0MetXaa: 0.0 ± 0.0
Asn	2.962AsnAla: 2.962 ± 0.069	0.228AsnCys: 0.228 ± 0.019	2.592AsnAsp: 2.592 ± 0.055	3.318AsnGlu: 3.318 ± 0.068	1.743AsnPhe: 1.743 ± 0.049	2.772AsnGly: 2.772 ± 0.07	1.073AsnHis: 1.073 ± 0.04	3.679AsnIle: 3.679 ± 0.075	2.334AsnLys: 2.334 ± 0.058	3.675AsnLeu: 3.675 ± 0.065	1.269AsnMet: 1.269 ± 0.039	1.69AsnAsn: 1.69 ± 0.053	1.766AsnPro: 1.766 ± 0.049	1.469AsnGln: 1.469 ± 0.046	1.921AsnArg: 1.921 ± 0.056	1.935AsnSer: 1.935 ± 0.063	2.192AsnThr: 2.192 ± 0.048	2.848AsnVal: 2.848 ± 0.064	0.315AsnTrp: 0.315 ± 0.019	1.609AsnTyr: 1.609 ± 0.047	0.0AsnXaa: 0.0 ± 0.0
Pro	2.52ProAla: 2.52 ± 0.066	0.166ProCys: 0.166 ± 0.014	2.432ProAsp: 2.432 ± 0.062	3.584ProGlu: 3.584 ± 0.08	1.8ProPhe: 1.8 ± 0.05	2.879ProGly: 2.879 ± 0.067	0.924ProHis: 0.924 ± 0.036	2.233ProIle: 2.233 ± 0.055	1.676ProLys: 1.676 ± 0.049	3.318ProLeu: 3.318 ± 0.068	0.951ProMet: 0.951 ± 0.034	1.174ProAsn: 1.174 ± 0.038	0.979ProPro: 0.979 ± 0.037	0.85ProGln: 0.85 ± 0.032	1.179ProArg: 1.179 ± 0.042	1.891ProSer: 1.891 ± 0.044	1.633ProThr: 1.633 ± 0.048	3.253ProVal: 3.253 ± 0.067	0.327ProTrp: 0.327 ± 0.022	1.248ProTyr: 1.248 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	2.11GlnAla: 2.11 ± 0.053	0.114GlnCys: 0.114 ± 0.011	1.66GlnAsp: 1.66 ± 0.05	2.259GlnGlu: 2.259 ± 0.055	1.368GlnPhe: 1.368 ± 0.044	1.778GlnGly: 1.778 ± 0.049	0.71GlnHis: 0.71 ± 0.035	1.969GlnIle: 1.969 ± 0.047	1.705GlnLys: 1.705 ± 0.045	2.926GlnLeu: 2.926 ± 0.058	0.989GlnMet: 0.989 ± 0.039	1.318GlnAsn: 1.318 ± 0.045	1.006GlnPro: 1.006 ± 0.035	0.963GlnGln: 0.963 ± 0.041	1.188GlnArg: 1.188 ± 0.04	1.713GlnSer: 1.713 ± 0.049	1.445GlnThr: 1.445 ± 0.038	1.852GlnVal: 1.852 ± 0.053	0.24GlnTrp: 0.24 ± 0.017	1.196GlnTyr: 1.196 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	2.884ArgAla: 2.884 ± 0.073	0.222ArgCys: 0.222 ± 0.018	2.548ArgAsp: 2.548 ± 0.064	3.736ArgGlu: 3.736 ± 0.082	1.99ArgPhe: 1.99 ± 0.049	2.664ArgGly: 2.664 ± 0.055	1.199ArgHis: 1.199 ± 0.042	3.192ArgIle: 3.192 ± 0.069	2.972ArgLys: 2.972 ± 0.059	4.098ArgLeu: 4.098 ± 0.076	1.623ArgMet: 1.623 ± 0.05	2.012ArgAsn: 2.012 ± 0.058	1.531ArgPro: 1.531 ± 0.047	1.591ArgGln: 1.591 ± 0.054	2.414ArgArg: 2.414 ± 0.061	2.3ArgSer: 2.3 ± 0.061	2.511ArgThr: 2.511 ± 0.071	2.84ArgVal: 2.84 ± 0.07	0.307ArgTrp: 0.307 ± 0.02	1.631ArgTyr: 1.631 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	4.03SerAla: 4.03 ± 0.081	0.289SerCys: 0.289 ± 0.021	3.427SerAsp: 3.427 ± 0.078	4.29SerGlu: 4.29 ± 0.083	2.861SerPhe: 2.861 ± 0.067	4.976SerGly: 4.976 ± 0.076	1.411SerHis: 1.411 ± 0.042	4.387SerIle: 4.387 ± 0.096	3.091SerLys: 3.091 ± 0.065	5.622SerLeu: 5.622 ± 0.104	1.727SerMet: 1.727 ± 0.043	2.191SerAsn: 2.191 ± 0.055	1.998SerPro: 1.998 ± 0.055	1.596SerGln: 1.596 ± 0.048	2.827SerArg: 2.827 ± 0.058	3.278SerSer: 3.278 ± 0.092	2.993SerThr: 2.993 ± 0.067	4.055SerVal: 4.055 ± 0.068	0.51SerTrp: 0.51 ± 0.026	2.063SerTyr: 2.063 ± 0.053	0.0SerXaa: 0.0 ± 0.0
Thr	4.186ThrAla: 4.186 ± 0.085	0.27ThrCys: 0.27 ± 0.021	3.395ThrAsp: 3.395 ± 0.07	4.111ThrGlu: 4.111 ± 0.076	2.575ThrPhe: 2.575 ± 0.062	4.919ThrGly: 4.919 ± 0.084	1.269ThrHis: 1.269 ± 0.04	4.013ThrIle: 4.013 ± 0.095	2.459ThrLys: 2.459 ± 0.059	5.281ThrLeu: 5.281 ± 0.091	1.426ThrMet: 1.426 ± 0.053	1.848ThrAsn: 1.848 ± 0.051	2.334ThrPro: 2.334 ± 0.055	1.301ThrGln: 1.301 ± 0.042	2.164ThrArg: 2.164 ± 0.058	3.149ThrSer: 3.149 ± 0.069	2.776ThrThr: 2.776 ± 0.064	4.597ThrVal: 4.597 ± 0.073	0.394ThrTrp: 0.394 ± 0.022	1.932ThrTyr: 1.932 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.004ValAla: 5.004 ± 0.095	0.437ValCys: 0.437 ± 0.028	4.421ValAsp: 4.421 ± 0.087	5.761ValGlu: 5.761 ± 0.108	3.164ValPhe: 3.164 ± 0.077	4.707ValGly: 4.707 ± 0.082	1.538ValHis: 1.538 ± 0.044	5.947ValIle: 5.947 ± 0.087	4.066ValLys: 4.066 ± 0.069	6.934ValLeu: 6.934 ± 0.108	2.227ValMet: 2.227 ± 0.058	3.03ValAsn: 3.03 ± 0.056	2.685ValPro: 2.685 ± 0.059	1.883ValGln: 1.883 ± 0.056	3.084ValArg: 3.084 ± 0.072	4.683ValSer: 4.683 ± 0.083	4.335ValThr: 4.335 ± 0.077	5.031ValVal: 5.031 ± 0.097	0.528ValTrp: 0.528 ± 0.025	2.308ValTyr: 2.308 ± 0.054	0.0ValXaa: 0.0 ± 0.0
Trp	0.551TrpAla: 0.551 ± 0.025	0.058TrpCys: 0.058 ± 0.009	0.406TrpAsp: 0.406 ± 0.029	0.494TrpGlu: 0.494 ± 0.027	0.451TrpPhe: 0.451 ± 0.028	0.586TrpGly: 0.586 ± 0.03	0.193TrpHis: 0.193 ± 0.017	0.586TrpIle: 0.586 ± 0.03	0.454TrpLys: 0.454 ± 0.025	0.925TrpLeu: 0.925 ± 0.034	0.356TrpMet: 0.356 ± 0.022	0.349TrpAsn: 0.349 ± 0.022	0.246TrpPro: 0.246 ± 0.017	0.3TrpGln: 0.3 ± 0.019	0.311TrpArg: 0.311 ± 0.019	0.414TrpSer: 0.414 ± 0.024	0.454TrpThr: 0.454 ± 0.025	0.491TrpVal: 0.491 ± 0.025	0.093TrpTrp: 0.093 ± 0.011	0.321TrpTyr: 0.321 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.252TyrAla: 2.252 ± 0.055	0.207TyrCys: 0.207 ± 0.018	2.543TyrAsp: 2.543 ± 0.064	2.938TyrGlu: 2.938 ± 0.075	1.794TyrPhe: 1.794 ± 0.057	2.686TyrGly: 2.686 ± 0.07	0.896TyrHis: 0.896 ± 0.036	2.78TyrIle: 2.78 ± 0.063	1.913TyrLys: 1.913 ± 0.054	3.209TyrLeu: 3.209 ± 0.065	0.987TyrMet: 0.987 ± 0.033	1.593TyrAsn: 1.593 ± 0.052	1.272TyrPro: 1.272 ± 0.046	1.188TyrGln: 1.188 ± 0.041	1.779TyrArg: 1.779 ± 0.054	2.047TyrSer: 2.047 ± 0.05	1.95TyrThr: 1.95 ± 0.052	2.163TyrVal: 2.163 ± 0.049	0.283TyrTrp: 0.283 ± 0.019	1.435TyrTyr: 1.435 ± 0.042	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2512 proteins (753143 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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