Amino acid dipepetide frequency for Arthrobacter phage Sonali

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
21.496AlaAla: 21.496 ± 3.303
0.783AlaCys: 0.783 ± 0.169
6.105AlaAsp: 6.105 ± 0.422
8.557AlaGlu: 8.557 ± 1.0
2.609AlaPhe: 2.609 ± 0.454
8.348AlaGly: 8.348 ± 0.834
3.026AlaHis: 3.026 ± 0.354
4.852AlaIle: 4.852 ± 0.549
5.739AlaLys: 5.739 ± 0.793
9.861AlaLeu: 9.861 ± 0.67
3.965AlaMet: 3.965 ± 0.348
3.965AlaAsn: 3.965 ± 0.487
9.966AlaPro: 9.966 ± 2.092
5.792AlaGln: 5.792 ± 0.831
8.087AlaArg: 8.087 ± 0.712
7.148AlaSer: 7.148 ± 0.698
8.922AlaThr: 8.922 ± 0.759
8.296AlaVal: 8.296 ± 0.676
2.4AlaTrp: 2.4 ± 0.417
2.661AlaTyr: 2.661 ± 0.362
0.0AlaXaa: 0.0 ± 0.0
Cys
0.783CysAla: 0.783 ± 0.202
0.104CysCys: 0.104 ± 0.083
0.626CysAsp: 0.626 ± 0.204
0.313CysGlu: 0.313 ± 0.126
0.209CysPhe: 0.209 ± 0.089
0.73CysGly: 0.73 ± 0.21
0.209CysHis: 0.209 ± 0.104
0.157CysIle: 0.157 ± 0.081
0.104CysLys: 0.104 ± 0.078
0.261CysLeu: 0.261 ± 0.123
0.052CysMet: 0.052 ± 0.047
0.313CysAsn: 0.313 ± 0.118
0.574CysPro: 0.574 ± 0.197
0.313CysGln: 0.313 ± 0.136
0.783CysArg: 0.783 ± 0.206
0.783CysSer: 0.783 ± 0.192
0.365CysThr: 0.365 ± 0.133
0.417CysVal: 0.417 ± 0.13
0.313CysTrp: 0.313 ± 0.138
0.157CysTyr: 0.157 ± 0.087
0.0CysXaa: 0.0 ± 0.0
Asp
7.148AspAla: 7.148 ± 0.557
0.365AspCys: 0.365 ± 0.139
3.183AspAsp: 3.183 ± 0.573
3.496AspGlu: 3.496 ± 0.499
1.722AspPhe: 1.722 ± 0.316
5.739AspGly: 5.739 ± 0.625
1.357AspHis: 1.357 ± 0.273
2.765AspIle: 2.765 ± 0.368
2.348AspLys: 2.348 ± 0.308
5.426AspLeu: 5.426 ± 0.723
0.73AspMet: 0.73 ± 0.19
1.304AspAsn: 1.304 ± 0.246
3.548AspPro: 3.548 ± 0.543
1.983AspGln: 1.983 ± 0.296
3.131AspArg: 3.131 ± 0.369
3.287AspSer: 3.287 ± 0.404
2.661AspThr: 2.661 ± 0.372
3.757AspVal: 3.757 ± 0.509
1.252AspTrp: 1.252 ± 0.304
1.826AspTyr: 1.826 ± 0.311
0.0AspXaa: 0.0 ± 0.0
Glu
9.026GluAla: 9.026 ± 1.052
0.574GluCys: 0.574 ± 0.21
2.817GluAsp: 2.817 ± 0.407
5.009GluGlu: 5.009 ± 0.66
2.191GluPhe: 2.191 ± 0.258
4.435GluGly: 4.435 ± 0.501
0.887GluHis: 0.887 ± 0.235
1.565GluIle: 1.565 ± 0.286
2.452GluLys: 2.452 ± 0.43
4.957GluLeu: 4.957 ± 0.67
1.252GluMet: 1.252 ± 0.277
1.878GluAsn: 1.878 ± 0.241
2.922GluPro: 2.922 ± 0.522
2.035GluGln: 2.035 ± 0.331
2.974GluArg: 2.974 ± 0.477
2.348GluSer: 2.348 ± 0.323
3.026GluThr: 3.026 ± 0.403
5.113GluVal: 5.113 ± 0.473
1.096GluTrp: 1.096 ± 0.224
1.409GluTyr: 1.409 ± 0.298
0.0GluXaa: 0.0 ± 0.0
Phe
3.183PheAla: 3.183 ± 0.527
0.157PheCys: 0.157 ± 0.077
2.035PheAsp: 2.035 ± 0.315
1.044PheGlu: 1.044 ± 0.201
0.73PhePhe: 0.73 ± 0.186
1.983PheGly: 1.983 ± 0.29
0.574PheHis: 0.574 ± 0.176
1.461PheIle: 1.461 ± 0.277
1.826PheLys: 1.826 ± 0.349
2.817PheLeu: 2.817 ± 0.375
0.365PheMet: 0.365 ± 0.116
1.2PheAsn: 1.2 ± 0.215
1.409PhePro: 1.409 ± 0.295
1.304PheGln: 1.304 ± 0.241
1.513PheArg: 1.513 ± 0.233
1.304PheSer: 1.304 ± 0.304
2.244PheThr: 2.244 ± 0.328
1.617PheVal: 1.617 ± 0.302
0.522PheTrp: 0.522 ± 0.189
0.261PheTyr: 0.261 ± 0.141
0.0PheXaa: 0.0 ± 0.0
Gly
8.348GlyAla: 8.348 ± 0.775
0.887GlyCys: 0.887 ± 0.227
5.009GlyAsp: 5.009 ± 0.517
3.913GlyGlu: 3.913 ± 0.449
2.765GlyPhe: 2.765 ± 0.427
7.409GlyGly: 7.409 ± 0.867
1.67GlyHis: 1.67 ± 0.348
3.652GlyIle: 3.652 ± 0.561
4.174GlyLys: 4.174 ± 0.534
6.887GlyLeu: 6.887 ± 0.525
1.826GlyMet: 1.826 ± 0.262
2.4GlyAsn: 2.4 ± 0.358
3.652GlyPro: 3.652 ± 0.444
4.018GlyGln: 4.018 ± 0.578
3.861GlyArg: 3.861 ± 0.435
5.948GlySer: 5.948 ± 0.624
6.157GlyThr: 6.157 ± 0.568
5.478GlyVal: 5.478 ± 0.56
1.617GlyTrp: 1.617 ± 0.281
1.983GlyTyr: 1.983 ± 0.337
0.0GlyXaa: 0.0 ± 0.0
His
1.826HisAla: 1.826 ± 0.411
0.313HisCys: 0.313 ± 0.122
1.409HisAsp: 1.409 ± 0.338
1.148HisGlu: 1.148 ± 0.22
0.678HisPhe: 0.678 ± 0.201
1.565HisGly: 1.565 ± 0.349
0.678HisHis: 0.678 ± 0.232
0.887HisIle: 0.887 ± 0.213
0.574HisLys: 0.574 ± 0.161
2.244HisLeu: 2.244 ± 0.359
0.365HisMet: 0.365 ± 0.148
0.783HisAsn: 0.783 ± 0.205
1.409HisPro: 1.409 ± 0.288
0.939HisGln: 0.939 ± 0.228
1.67HisArg: 1.67 ± 0.338
0.783HisSer: 0.783 ± 0.219
0.939HisThr: 0.939 ± 0.247
1.148HisVal: 1.148 ± 0.291
0.261HisTrp: 0.261 ± 0.119
0.678HisTyr: 0.678 ± 0.208
0.0HisXaa: 0.0 ± 0.0
Ile
6.783IleAla: 6.783 ± 0.568
0.261IleCys: 0.261 ± 0.117
3.235IleAsp: 3.235 ± 0.355
2.244IleGlu: 2.244 ± 0.367
0.626IlePhe: 0.626 ± 0.131
3.809IleGly: 3.809 ± 0.673
0.939IleHis: 0.939 ± 0.281
1.67IleIle: 1.67 ± 0.296
1.774IleLys: 1.774 ± 0.315
2.296IleLeu: 2.296 ± 0.312
0.678IleMet: 0.678 ± 0.157
2.087IleAsn: 2.087 ± 0.29
2.4IlePro: 2.4 ± 0.354
1.983IleGln: 1.983 ± 0.291
2.087IleArg: 2.087 ± 0.324
1.826IleSer: 1.826 ± 0.335
4.539IleThr: 4.539 ± 0.659
2.609IleVal: 2.609 ± 0.366
0.47IleTrp: 0.47 ± 0.123
1.096IleTyr: 1.096 ± 0.281
0.0IleXaa: 0.0 ± 0.0
Lys
7.461LysAla: 7.461 ± 1.329
0.157LysCys: 0.157 ± 0.082
2.087LysAsp: 2.087 ± 0.305
2.191LysGlu: 2.191 ± 0.308
1.044LysPhe: 1.044 ± 0.219
2.87LysGly: 2.87 ± 0.428
0.678LysHis: 0.678 ± 0.192
1.304LysIle: 1.304 ± 0.278
1.409LysLys: 1.409 ± 0.348
3.496LysLeu: 3.496 ± 0.483
0.835LysMet: 0.835 ± 0.202
0.939LysAsn: 0.939 ± 0.2
3.235LysPro: 3.235 ± 0.48
1.878LysGln: 1.878 ± 0.327
3.026LysArg: 3.026 ± 0.52
1.878LysSer: 1.878 ± 0.447
2.244LysThr: 2.244 ± 0.336
4.018LysVal: 4.018 ± 0.439
0.47LysTrp: 0.47 ± 0.132
0.991LysTyr: 0.991 ± 0.226
0.0LysXaa: 0.0 ± 0.0
Leu
10.853LeuAla: 10.853 ± 0.763
0.261LeuCys: 0.261 ± 0.136
6.052LeuAsp: 6.052 ± 0.621
4.331LeuGlu: 4.331 ± 0.599
1.461LeuPhe: 1.461 ± 0.287
5.583LeuGly: 5.583 ± 0.506
1.826LeuHis: 1.826 ± 0.33
3.496LeuIle: 3.496 ± 0.415
2.504LeuLys: 2.504 ± 0.391
6.522LeuLeu: 6.522 ± 0.773
1.826LeuMet: 1.826 ± 0.282
3.339LeuAsn: 3.339 ± 0.371
5.009LeuPro: 5.009 ± 0.633
3.235LeuGln: 3.235 ± 0.445
4.644LeuArg: 4.644 ± 0.522
4.696LeuSer: 4.696 ± 0.546
5.948LeuThr: 5.948 ± 0.6
6.157LeuVal: 6.157 ± 0.691
0.991LeuTrp: 0.991 ± 0.232
1.565LeuTyr: 1.565 ± 0.33
0.0LeuXaa: 0.0 ± 0.0
Met
2.557MetAla: 2.557 ± 0.355
0.104MetCys: 0.104 ± 0.065
0.887MetAsp: 0.887 ± 0.191
1.148MetGlu: 1.148 ± 0.265
0.626MetPhe: 0.626 ± 0.166
1.2MetGly: 1.2 ± 0.261
0.209MetHis: 0.209 ± 0.101
0.991MetIle: 0.991 ± 0.249
0.835MetLys: 0.835 ± 0.217
0.991MetLeu: 0.991 ± 0.188
0.261MetMet: 0.261 ± 0.122
0.417MetAsn: 0.417 ± 0.134
1.409MetPro: 1.409 ± 0.234
0.835MetGln: 0.835 ± 0.183
0.574MetArg: 0.574 ± 0.172
2.661MetSer: 2.661 ± 0.345
2.765MetThr: 2.765 ± 0.434
1.409MetVal: 1.409 ± 0.271
0.261MetTrp: 0.261 ± 0.126
0.417MetTyr: 0.417 ± 0.139
0.0MetXaa: 0.0 ± 0.0
Asn
4.383AsnAla: 4.383 ± 0.507
0.365AsnCys: 0.365 ± 0.134
1.461AsnAsp: 1.461 ± 0.251
1.357AsnGlu: 1.357 ± 0.291
1.565AsnPhe: 1.565 ± 0.221
3.235AsnGly: 3.235 ± 0.391
0.835AsnHis: 0.835 ± 0.226
1.774AsnIle: 1.774 ± 0.311
0.73AsnLys: 0.73 ± 0.166
2.348AsnLeu: 2.348 ± 0.293
0.365AsnMet: 0.365 ± 0.138
0.522AsnAsn: 0.522 ± 0.15
2.922AsnPro: 2.922 ± 0.453
0.991AsnGln: 0.991 ± 0.19
1.774AsnArg: 1.774 ± 0.354
1.461AsnSer: 1.461 ± 0.268
2.4AsnThr: 2.4 ± 0.445
2.087AsnVal: 2.087 ± 0.4
0.47AsnTrp: 0.47 ± 0.137
0.73AsnTyr: 0.73 ± 0.192
0.0AsnXaa: 0.0 ± 0.0
Pro
9.444ProAla: 9.444 ± 2.004
0.365ProCys: 0.365 ± 0.118
3.913ProAsp: 3.913 ± 0.578
4.122ProGlu: 4.122 ± 0.712
2.348ProPhe: 2.348 ± 0.35
6.47ProGly: 6.47 ± 0.768
0.939ProHis: 0.939 ± 0.203
2.191ProIle: 2.191 ± 0.388
2.609ProLys: 2.609 ± 0.307
3.548ProLeu: 3.548 ± 0.48
1.096ProMet: 1.096 ± 0.213
1.878ProAsn: 1.878 ± 0.358
2.922ProPro: 2.922 ± 0.566
1.357ProGln: 1.357 ± 0.221
2.244ProArg: 2.244 ± 0.412
3.235ProSer: 3.235 ± 0.462
4.644ProThr: 4.644 ± 0.494
5.635ProVal: 5.635 ± 0.587
0.678ProTrp: 0.678 ± 0.166
1.409ProTyr: 1.409 ± 0.268
0.0ProXaa: 0.0 ± 0.0
Gln
7.2GlnAla: 7.2 ± 0.642
0.209GlnCys: 0.209 ± 0.116
2.452GlnAsp: 2.452 ± 0.333
3.235GlnGlu: 3.235 ± 0.384
1.252GlnPhe: 1.252 ± 0.242
3.078GlnGly: 3.078 ± 0.449
0.574GlnHis: 0.574 ± 0.197
1.617GlnIle: 1.617 ± 0.354
0.939GlnLys: 0.939 ± 0.297
2.87GlnLeu: 2.87 ± 0.436
0.783GlnMet: 0.783 ± 0.168
1.096GlnAsn: 1.096 ± 0.262
2.035GlnPro: 2.035 ± 0.383
0.887GlnGln: 0.887 ± 0.197
1.722GlnArg: 1.722 ± 0.301
1.409GlnSer: 1.409 ± 0.264
2.087GlnThr: 2.087 ± 0.309
4.122GlnVal: 4.122 ± 0.487
0.783GlnTrp: 0.783 ± 0.207
0.783GlnTyr: 0.783 ± 0.187
0.0GlnXaa: 0.0 ± 0.0
Arg
6.835ArgAla: 6.835 ± 0.788
0.522ArgCys: 0.522 ± 0.209
2.87ArgAsp: 2.87 ± 0.444
3.078ArgGlu: 3.078 ± 0.406
1.565ArgPhe: 1.565 ± 0.349
4.278ArgGly: 4.278 ± 0.519
1.513ArgHis: 1.513 ± 0.295
2.557ArgIle: 2.557 ± 0.395
3.6ArgLys: 3.6 ± 0.533
5.687ArgLeu: 5.687 ± 0.586
1.2ArgMet: 1.2 ± 0.252
2.244ArgAsn: 2.244 ± 0.281
3.339ArgPro: 3.339 ± 0.529
2.452ArgGln: 2.452 ± 0.362
3.861ArgArg: 3.861 ± 0.587
2.244ArgSer: 2.244 ± 0.378
3.235ArgThr: 3.235 ± 0.454
3.235ArgVal: 3.235 ± 0.365
0.73ArgTrp: 0.73 ± 0.216
1.461ArgTyr: 1.461 ± 0.299
0.0ArgXaa: 0.0 ± 0.0
Ser
5.531SerAla: 5.531 ± 0.491
0.626SerCys: 0.626 ± 0.192
2.504SerAsp: 2.504 ± 0.363
2.244SerGlu: 2.244 ± 0.303
1.409SerPhe: 1.409 ± 0.284
5.478SerGly: 5.478 ± 0.65
0.626SerHis: 0.626 ± 0.19
3.444SerIle: 3.444 ± 0.417
2.609SerLys: 2.609 ± 0.401
4.957SerLeu: 4.957 ± 0.493
1.513SerMet: 1.513 ± 0.253
1.409SerAsn: 1.409 ± 0.259
3.391SerPro: 3.391 ± 0.445
1.931SerGln: 1.931 ± 0.277
3.235SerArg: 3.235 ± 0.39
4.018SerSer: 4.018 ± 0.553
4.018SerThr: 4.018 ± 0.636
4.278SerVal: 4.278 ± 0.546
1.2SerTrp: 1.2 ± 0.25
1.617SerTyr: 1.617 ± 0.279
0.0SerXaa: 0.0 ± 0.0
Thr
7.931ThrAla: 7.931 ± 0.936
0.417ThrCys: 0.417 ± 0.157
3.496ThrAsp: 3.496 ± 0.43
3.235ThrGlu: 3.235 ± 0.462
2.191ThrPhe: 2.191 ± 0.343
6.574ThrGly: 6.574 ± 0.604
1.044ThrHis: 1.044 ± 0.253
4.07ThrIle: 4.07 ± 0.52
2.557ThrLys: 2.557 ± 0.355
6.0ThrLeu: 6.0 ± 0.647
1.096ThrMet: 1.096 ± 0.175
2.609ThrAsn: 2.609 ± 0.566
5.322ThrPro: 5.322 ± 0.603
1.931ThrGln: 1.931 ± 0.269
3.809ThrArg: 3.809 ± 0.5
4.174ThrSer: 4.174 ± 0.55
5.218ThrThr: 5.218 ± 0.677
6.261ThrVal: 6.261 ± 0.734
1.304ThrTrp: 1.304 ± 0.236
1.722ThrTyr: 1.722 ± 0.363
0.0ThrXaa: 0.0 ± 0.0
Val
7.826ValAla: 7.826 ± 0.793
0.626ValCys: 0.626 ± 0.173
3.913ValAsp: 3.913 ± 0.465
5.426ValGlu: 5.426 ± 0.586
1.461ValPhe: 1.461 ± 0.267
5.27ValGly: 5.27 ± 0.495
1.565ValHis: 1.565 ± 0.264
3.444ValIle: 3.444 ± 0.401
3.809ValLys: 3.809 ± 0.538
5.322ValLeu: 5.322 ± 0.537
1.513ValMet: 1.513 ± 0.234
1.983ValAsn: 1.983 ± 0.259
3.704ValPro: 3.704 ± 0.59
3.496ValGln: 3.496 ± 0.431
5.27ValArg: 5.27 ± 0.512
4.696ValSer: 4.696 ± 0.516
6.678ValThr: 6.678 ± 0.643
4.748ValVal: 4.748 ± 0.591
1.044ValTrp: 1.044 ± 0.202
1.67ValTyr: 1.67 ± 0.246
0.0ValXaa: 0.0 ± 0.0
Trp
1.409TrpAla: 1.409 ± 0.329
0.209TrpCys: 0.209 ± 0.094
1.461TrpAsp: 1.461 ± 0.296
1.148TrpGlu: 1.148 ± 0.261
0.417TrpPhe: 0.417 ± 0.177
1.148TrpGly: 1.148 ± 0.246
0.574TrpHis: 0.574 ± 0.166
0.522TrpIle: 0.522 ± 0.17
0.783TrpLys: 0.783 ± 0.177
1.565TrpLeu: 1.565 ± 0.293
0.313TrpMet: 0.313 ± 0.119
0.574TrpAsn: 0.574 ± 0.145
0.626TrpPro: 0.626 ± 0.197
0.678TrpGln: 0.678 ± 0.213
0.991TrpArg: 0.991 ± 0.238
0.783TrpSer: 0.783 ± 0.211
1.304TrpThr: 1.304 ± 0.267
1.565TrpVal: 1.565 ± 0.233
0.313TrpTrp: 0.313 ± 0.114
0.365TrpTyr: 0.365 ± 0.136
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.557TyrAla: 2.557 ± 0.337
0.261TyrCys: 0.261 ± 0.143
1.513TyrAsp: 1.513 ± 0.264
0.73TyrGlu: 0.73 ± 0.184
0.678TyrPhe: 0.678 ± 0.201
2.452TyrGly: 2.452 ± 0.37
0.574TyrHis: 0.574 ± 0.18
0.991TyrIle: 0.991 ± 0.246
0.835TyrLys: 0.835 ± 0.206
2.244TyrLeu: 2.244 ± 0.28
0.47TyrMet: 0.47 ± 0.126
0.835TyrAsn: 0.835 ± 0.25
1.252TyrPro: 1.252 ± 0.249
1.096TyrGln: 1.096 ± 0.317
1.304TyrArg: 1.304 ± 0.235
1.357TyrSer: 1.357 ± 0.295
1.565TyrThr: 1.565 ± 0.329
1.513TyrVal: 1.513 ± 0.324
0.574TyrTrp: 0.574 ± 0.199
0.417TyrTyr: 0.417 ± 0.136
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 99 proteins (19167 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski