Amino acid dipepetide frequency for Drancourtella sp. An57

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.207AlaAla: 7.207 ± 0.134
1.172AlaCys: 1.172 ± 0.037
4.304AlaAsp: 4.304 ± 0.066
5.582AlaGlu: 5.582 ± 0.088
3.059AlaPhe: 3.059 ± 0.057
6.551AlaGly: 6.551 ± 0.103
1.107AlaHis: 1.107 ± 0.037
4.088AlaIle: 4.088 ± 0.077
4.723AlaLys: 4.723 ± 0.1
6.722AlaLeu: 6.722 ± 0.075
2.227AlaMet: 2.227 ± 0.048
2.203AlaAsn: 2.203 ± 0.052
1.971AlaPro: 1.971 ± 0.048
2.124AlaGln: 2.124 ± 0.053
3.132AlaArg: 3.132 ± 0.054
3.924AlaSer: 3.924 ± 0.067
2.536AlaThr: 2.536 ± 0.06
6.655AlaVal: 6.655 ± 0.098
0.681AlaTrp: 0.681 ± 0.026
2.665AlaTyr: 2.665 ± 0.058
0.0AlaXaa: 0.0 ± 0.0
Cys
0.971CysAla: 0.971 ± 0.035
0.275CysCys: 0.275 ± 0.02
0.756CysAsp: 0.756 ± 0.027
0.973CysGlu: 0.973 ± 0.031
0.65CysPhe: 0.65 ± 0.026
1.523CysGly: 1.523 ± 0.047
0.346CysHis: 0.346 ± 0.02
1.09CysIle: 1.09 ± 0.04
0.73CysLys: 0.73 ± 0.029
1.181CysLeu: 1.181 ± 0.035
0.475CysMet: 0.475 ± 0.022
0.475CysAsn: 0.475 ± 0.021
0.713CysPro: 0.713 ± 0.033
0.426CysGln: 0.426 ± 0.02
0.884CysArg: 0.884 ± 0.033
0.868CysSer: 0.868 ± 0.032
0.739CysThr: 0.739 ± 0.032
0.979CysVal: 0.979 ± 0.036
0.107CysTrp: 0.107 ± 0.01
0.541CysTyr: 0.541 ± 0.023
0.0CysXaa: 0.0 ± 0.0
Asp
3.87AspAla: 3.87 ± 0.075
0.804AspCys: 0.804 ± 0.029
2.615AspAsp: 2.615 ± 0.058
4.739AspGlu: 4.739 ± 0.078
2.529AspPhe: 2.529 ± 0.049
4.479AspGly: 4.479 ± 0.077
0.999AspHis: 0.999 ± 0.033
4.135AspIle: 4.135 ± 0.069
2.92AspLys: 2.92 ± 0.056
4.936AspLeu: 4.936 ± 0.076
1.723AspMet: 1.723 ± 0.039
1.788AspAsn: 1.788 ± 0.045
2.038AspPro: 2.038 ± 0.05
1.809AspGln: 1.809 ± 0.044
2.814AspArg: 2.814 ± 0.058
2.843AspSer: 2.843 ± 0.057
2.958AspThr: 2.958 ± 0.058
3.833AspVal: 3.833 ± 0.068
0.611AspTrp: 0.611 ± 0.029
2.591AspTyr: 2.591 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
6.166GluAla: 6.166 ± 0.09
0.851GluCys: 0.851 ± 0.032
4.565GluAsp: 4.565 ± 0.075
9.607GluGlu: 9.607 ± 0.15
2.787GluPhe: 2.787 ± 0.053
4.954GluGly: 4.954 ± 0.077
1.524GluHis: 1.524 ± 0.04
6.324GluIle: 6.324 ± 0.083
7.646GluLys: 7.646 ± 0.096
6.83GluLeu: 6.83 ± 0.102
2.891GluMet: 2.891 ± 0.057
4.065GluAsn: 4.065 ± 0.064
2.101GluPro: 2.101 ± 0.049
3.289GluGln: 3.289 ± 0.074
3.877GluArg: 3.877 ± 0.084
3.597GluSer: 3.597 ± 0.064
4.507GluThr: 4.507 ± 0.072
4.821GluVal: 4.821 ± 0.068
0.795GluTrp: 0.795 ± 0.028
3.385GluTyr: 3.385 ± 0.066
0.0GluXaa: 0.0 ± 0.0
Phe
2.861PheAla: 2.861 ± 0.063
0.766PheCys: 0.766 ± 0.03
2.367PheAsp: 2.367 ± 0.046
2.866PheGlu: 2.866 ± 0.058
1.927PhePhe: 1.927 ± 0.048
3.142PheGly: 3.142 ± 0.067
0.949PheHis: 0.949 ± 0.032
2.545PheIle: 2.545 ± 0.054
1.634PheLys: 1.634 ± 0.048
4.267PheLeu: 4.267 ± 0.078
1.086PheMet: 1.086 ± 0.036
1.171PheAsn: 1.171 ± 0.037
1.498PhePro: 1.498 ± 0.04
1.505PheGln: 1.505 ± 0.042
2.075PheArg: 2.075 ± 0.048
2.819PheSer: 2.819 ± 0.062
2.251PheThr: 2.251 ± 0.049
2.692PheVal: 2.692 ± 0.051
0.434PheTrp: 0.434 ± 0.024
1.789PheTyr: 1.789 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
4.92GlyAla: 4.92 ± 0.076
1.352GlyCys: 1.352 ± 0.041
3.445GlyAsp: 3.445 ± 0.066
5.395GlyGlu: 5.395 ± 0.086
3.098GlyPhe: 3.098 ± 0.06
4.828GlyGly: 4.828 ± 0.088
1.261GlyHis: 1.261 ± 0.036
6.346GlyIle: 6.346 ± 0.092
5.746GlyLys: 5.746 ± 0.078
5.743GlyLeu: 5.743 ± 0.082
2.489GlyMet: 2.489 ± 0.05
2.992GlyAsn: 2.992 ± 0.06
1.405GlyPro: 1.405 ± 0.036
2.236GlyGln: 2.236 ± 0.052
3.495GlyArg: 3.495 ± 0.062
3.976GlySer: 3.976 ± 0.075
4.528GlyThr: 4.528 ± 0.077
4.863GlyVal: 4.863 ± 0.085
0.784GlyTrp: 0.784 ± 0.042
3.306GlyTyr: 3.306 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
1.217HisAla: 1.217 ± 0.03
0.322HisCys: 0.322 ± 0.018
0.983HisAsp: 0.983 ± 0.029
1.153HisGlu: 1.153 ± 0.04
0.821HisPhe: 0.821 ± 0.03
1.339HisGly: 1.339 ± 0.04
0.467HisHis: 0.467 ± 0.027
1.394HisIle: 1.394 ± 0.043
0.886HisLys: 0.886 ± 0.032
1.634HisLeu: 1.634 ± 0.043
0.568HisMet: 0.568 ± 0.024
0.644HisAsn: 0.644 ± 0.024
1.005HisPro: 1.005 ± 0.037
0.592HisGln: 0.592 ± 0.024
0.848HisArg: 0.848 ± 0.027
0.971HisSer: 0.971 ± 0.032
1.012HisThr: 1.012 ± 0.033
1.27HisVal: 1.27 ± 0.041
0.176HisTrp: 0.176 ± 0.014
0.814HisTyr: 0.814 ± 0.026
0.0HisXaa: 0.0 ± 0.0
Ile
5.183IleAla: 5.183 ± 0.072
1.306IleCys: 1.306 ± 0.047
3.885IleAsp: 3.885 ± 0.071
4.944IleGlu: 4.944 ± 0.076
2.783IlePhe: 2.783 ± 0.064
5.116IleGly: 5.116 ± 0.08
1.476IleHis: 1.476 ± 0.04
4.457IleIle: 4.457 ± 0.081
3.388IleLys: 3.388 ± 0.064
7.452IleLeu: 7.452 ± 0.108
1.891IleMet: 1.891 ± 0.047
2.305IleAsn: 2.305 ± 0.054
3.228IlePro: 3.228 ± 0.056
2.592IleGln: 2.592 ± 0.058
4.727IleArg: 4.727 ± 0.072
4.498IleSer: 4.498 ± 0.07
3.854IleThr: 3.854 ± 0.062
4.918IleVal: 4.918 ± 0.074
0.703IleTrp: 0.703 ± 0.03
2.714IleTyr: 2.714 ± 0.062
0.0IleXaa: 0.0 ± 0.0
Lys
4.903LysAla: 4.903 ± 0.084
0.687LysCys: 0.687 ± 0.028
3.786LysAsp: 3.786 ± 0.07
7.731LysGlu: 7.731 ± 0.104
1.756LysPhe: 1.756 ± 0.044
4.319LysGly: 4.319 ± 0.07
1.022LysHis: 1.022 ± 0.036
4.767LysIle: 4.767 ± 0.067
6.433LysLys: 6.433 ± 0.086
5.035LysLeu: 5.035 ± 0.08
2.268LysMet: 2.268 ± 0.046
3.073LysAsn: 3.073 ± 0.059
1.913LysPro: 1.913 ± 0.048
2.425LysGln: 2.425 ± 0.058
3.488LysArg: 3.488 ± 0.056
3.009LysSer: 3.009 ± 0.065
3.713LysThr: 3.713 ± 0.068
4.086LysVal: 4.086 ± 0.059
0.625LysTrp: 0.625 ± 0.026
2.614LysTyr: 2.614 ± 0.048
0.0LysXaa: 0.0 ± 0.0
Leu
6.607LeuAla: 6.607 ± 0.089
1.457LeuCys: 1.457 ± 0.042
5.041LeuAsp: 5.041 ± 0.08
6.754LeuGlu: 6.754 ± 0.088
3.856LeuPhe: 3.856 ± 0.075
5.788LeuGly: 5.788 ± 0.077
1.619LeuHis: 1.619 ± 0.046
6.15LeuIle: 6.15 ± 0.089
6.279LeuLys: 6.279 ± 0.084
8.582LeuLeu: 8.582 ± 0.138
2.617LeuMet: 2.617 ± 0.057
3.579LeuAsn: 3.579 ± 0.061
3.61LeuPro: 3.61 ± 0.068
2.849LeuGln: 2.849 ± 0.054
3.953LeuArg: 3.953 ± 0.062
6.143LeuSer: 6.143 ± 0.095
5.018LeuThr: 5.018 ± 0.081
5.184LeuVal: 5.184 ± 0.077
0.746LeuTrp: 0.746 ± 0.029
3.448LeuTyr: 3.448 ± 0.065
0.0LeuXaa: 0.0 ± 0.0
Met
2.277MetAla: 2.277 ± 0.051
0.33MetCys: 0.33 ± 0.015
1.907MetAsp: 1.907 ± 0.047
3.087MetGlu: 3.087 ± 0.055
0.979MetPhe: 0.979 ± 0.033
1.953MetGly: 1.953 ± 0.052
0.46MetHis: 0.46 ± 0.022
2.358MetIle: 2.358 ± 0.045
2.81MetLys: 2.81 ± 0.051
2.666MetLeu: 2.666 ± 0.062
1.069MetMet: 1.069 ± 0.038
1.466MetAsn: 1.466 ± 0.037
1.115MetPro: 1.115 ± 0.034
1.05MetGln: 1.05 ± 0.033
1.415MetArg: 1.415 ± 0.037
1.695MetSer: 1.695 ± 0.043
1.81MetThr: 1.81 ± 0.046
1.773MetVal: 1.773 ± 0.044
0.258MetTrp: 0.258 ± 0.018
0.931MetTyr: 0.931 ± 0.03
0.0MetXaa: 0.0 ± 0.0
Asn
2.739AsnAla: 2.739 ± 0.06
0.531AsnCys: 0.531 ± 0.021
1.813AsnAsp: 1.813 ± 0.045
2.83AsnGlu: 2.83 ± 0.058
1.409AsnPhe: 1.409 ± 0.037
3.245AsnGly: 3.245 ± 0.065
0.792AsnHis: 0.792 ± 0.027
2.833AsnIle: 2.833 ± 0.058
1.98AsnLys: 1.98 ± 0.051
3.488AsnLeu: 3.488 ± 0.062
1.279AsnMet: 1.279 ± 0.039
1.424AsnAsn: 1.424 ± 0.048
1.891AsnPro: 1.891 ± 0.049
1.478AsnGln: 1.478 ± 0.042
2.024AsnArg: 2.024 ± 0.04
1.974AsnSer: 1.974 ± 0.044
2.129AsnThr: 2.129 ± 0.057
2.504AsnVal: 2.504 ± 0.068
0.4AsnTrp: 0.4 ± 0.022
1.656AsnTyr: 1.656 ± 0.038
0.0AsnXaa: 0.0 ± 0.0
Pro
2.476ProAla: 2.476 ± 0.063
0.426ProCys: 0.426 ± 0.024
2.602ProAsp: 2.602 ± 0.056
3.856ProGlu: 3.856 ± 0.077
1.606ProPhe: 1.606 ± 0.048
2.566ProGly: 2.566 ± 0.058
0.568ProHis: 0.568 ± 0.022
1.793ProIle: 1.793 ± 0.043
1.99ProLys: 1.99 ± 0.046
2.709ProLeu: 2.709 ± 0.058
0.882ProMet: 0.882 ± 0.028
1.157ProAsn: 1.157 ± 0.034
0.735ProPro: 0.735 ± 0.03
1.024ProGln: 1.024 ± 0.034
0.992ProArg: 0.992 ± 0.035
1.747ProSer: 1.747 ± 0.045
1.461ProThr: 1.461 ± 0.041
3.212ProVal: 3.212 ± 0.059
0.351ProTrp: 0.351 ± 0.02
1.551ProTyr: 1.551 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.425GlnAla: 2.425 ± 0.055
0.338GlnCys: 0.338 ± 0.016
1.703GlnAsp: 1.703 ± 0.044
3.242GlnGlu: 3.242 ± 0.07
1.241GlnPhe: 1.241 ± 0.034
2.085GlnGly: 2.085 ± 0.047
0.456GlnHis: 0.456 ± 0.023
2.968GlnIle: 2.968 ± 0.054
2.99GlnLys: 2.99 ± 0.067
2.545GlnLeu: 2.545 ± 0.062
1.268GlnMet: 1.268 ± 0.037
1.664GlnAsn: 1.664 ± 0.04
0.869GlnPro: 0.869 ± 0.03
1.038GlnGln: 1.038 ± 0.038
1.454GlnArg: 1.454 ± 0.041
1.695GlnSer: 1.695 ± 0.044
1.853GlnThr: 1.853 ± 0.044
2.09GlnVal: 2.09 ± 0.046
0.325GlnTrp: 0.325 ± 0.02
1.509GlnTyr: 1.509 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
2.936ArgAla: 2.936 ± 0.063
0.611ArgCys: 0.611 ± 0.027
2.368ArgAsp: 2.368 ± 0.053
4.572ArgGlu: 4.572 ± 0.086
2.066ArgPhe: 2.066 ± 0.044
2.694ArgGly: 2.694 ± 0.047
0.923ArgHis: 0.923 ± 0.03
4.095ArgIle: 4.095 ± 0.068
4.385ArgLys: 4.385 ± 0.071
4.214ArgLeu: 4.214 ± 0.073
1.82ArgMet: 1.82 ± 0.051
2.127ArgAsn: 2.127 ± 0.046
1.52ArgPro: 1.52 ± 0.045
1.879ArgGln: 1.879 ± 0.045
2.733ArgArg: 2.733 ± 0.062
2.411ArgSer: 2.411 ± 0.045
2.718ArgThr: 2.718 ± 0.058
2.663ArgVal: 2.663 ± 0.059
0.447ArgTrp: 0.447 ± 0.02
2.162ArgTyr: 2.162 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
4.013SerAla: 4.013 ± 0.074
0.833SerCys: 0.833 ± 0.031
3.089SerAsp: 3.089 ± 0.069
4.073SerGlu: 4.073 ± 0.073
2.48SerPhe: 2.48 ± 0.054
5.197SerGly: 5.197 ± 0.094
0.981SerHis: 0.981 ± 0.031
3.807SerIle: 3.807 ± 0.067
2.809SerLys: 2.809 ± 0.066
4.957SerLeu: 4.957 ± 0.066
1.914SerMet: 1.914 ± 0.05
1.852SerAsn: 1.852 ± 0.045
1.733SerPro: 1.733 ± 0.043
1.666SerGln: 1.666 ± 0.044
3.067SerArg: 3.067 ± 0.053
3.365SerSer: 3.365 ± 0.085
2.545SerThr: 2.545 ± 0.055
4.039SerVal: 4.039 ± 0.067
0.56SerTrp: 0.56 ± 0.028
2.403SerTyr: 2.403 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
4.378ThrAla: 4.378 ± 0.071
0.692ThrCys: 0.692 ± 0.025
3.168ThrAsp: 3.168 ± 0.062
4.24ThrGlu: 4.24 ± 0.073
2.174ThrPhe: 2.174 ± 0.047
4.775ThrGly: 4.775 ± 0.085
0.868ThrHis: 0.868 ± 0.026
3.832ThrIle: 3.832 ± 0.07
3.029ThrLys: 3.029 ± 0.052
4.637ThrLeu: 4.637 ± 0.065
1.443ThrMet: 1.443 ± 0.035
1.807ThrAsn: 1.807 ± 0.045
2.028ThrPro: 2.028 ± 0.043
1.472ThrGln: 1.472 ± 0.046
2.148ThrArg: 2.148 ± 0.049
2.797ThrSer: 2.797 ± 0.065
2.663ThrThr: 2.663 ± 0.071
4.464ThrVal: 4.464 ± 0.069
0.484ThrTrp: 0.484 ± 0.024
2.065ThrTyr: 2.065 ± 0.051
0.0ThrXaa: 0.0 ± 0.0
Val
4.231ValAla: 4.231 ± 0.078
1.206ValCys: 1.206 ± 0.034
3.544ValAsp: 3.544 ± 0.072
4.757ValGlu: 4.757 ± 0.08
3.166ValPhe: 3.166 ± 0.068
3.969ValGly: 3.969 ± 0.07
1.184ValHis: 1.184 ± 0.039
4.985ValIle: 4.985 ± 0.084
4.457ValLys: 4.457 ± 0.071
6.932ValLeu: 6.932 ± 0.094
2.039ValMet: 2.039 ± 0.047
2.519ValAsn: 2.519 ± 0.05
2.577ValPro: 2.577 ± 0.058
2.144ValGln: 2.144 ± 0.059
3.432ValArg: 3.432 ± 0.068
4.39ValSer: 4.39 ± 0.076
4.167ValThr: 4.167 ± 0.066
4.606ValVal: 4.606 ± 0.085
0.671ValTrp: 0.671 ± 0.025
2.729ValTyr: 2.729 ± 0.058
0.0ValXaa: 0.0 ± 0.0
Trp
0.532TrpAla: 0.532 ± 0.022
0.154TrpCys: 0.154 ± 0.013
0.582TrpAsp: 0.582 ± 0.029
0.785TrpGlu: 0.785 ± 0.028
0.44TrpPhe: 0.44 ± 0.022
0.63TrpGly: 0.63 ± 0.025
0.176TrpHis: 0.176 ± 0.015
0.798TrpIle: 0.798 ± 0.029
0.855TrpLys: 0.855 ± 0.031
0.848TrpLeu: 0.848 ± 0.031
0.399TrpMet: 0.399 ± 0.022
0.567TrpAsn: 0.567 ± 0.025
0.215TrpPro: 0.215 ± 0.016
0.379TrpGln: 0.379 ± 0.021
0.396TrpArg: 0.396 ± 0.022
0.451TrpSer: 0.451 ± 0.024
0.47TrpThr: 0.47 ± 0.021
0.464TrpVal: 0.464 ± 0.022
0.109TrpTrp: 0.109 ± 0.011
0.409TrpTyr: 0.409 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.722TyrAla: 2.722 ± 0.054
0.59TyrCys: 0.59 ± 0.026
2.511TyrAsp: 2.511 ± 0.056
3.394TyrGlu: 3.394 ± 0.066
1.816TyrPhe: 1.816 ± 0.046
3.053TyrGly: 3.053 ± 0.053
0.934TyrHis: 0.934 ± 0.036
2.653TyrIle: 2.653 ± 0.056
1.966TyrLys: 1.966 ± 0.048
3.902TyrLeu: 3.902 ± 0.073
1.06TyrMet: 1.06 ± 0.037
1.542TyrAsn: 1.542 ± 0.047
1.542TyrPro: 1.542 ± 0.043
1.782TyrGln: 1.782 ± 0.048
2.389TyrArg: 2.389 ± 0.052
2.212TyrSer: 2.212 ± 0.048
2.231TyrThr: 2.231 ± 0.051
2.59TyrVal: 2.59 ± 0.057
0.393TyrTrp: 0.393 ± 0.024
1.905TyrTyr: 1.905 ± 0.051
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3069 proteins (969582 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski