Amino acid dipepetide frequency for Rotavirus A EC2184/ECU/G11P[6]

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.476AlaAla: 2.476 ± 0.941
0.825AlaCys: 0.825 ± 0.387
4.402AlaAsp: 4.402 ± 0.926
2.751AlaGlu: 2.751 ± 0.783
1.376AlaPhe: 1.376 ± 0.534
2.201AlaGly: 2.201 ± 0.825
0.275AlaHis: 0.275 ± 0.233
3.301AlaIle: 3.301 ± 0.746
2.751AlaLys: 2.751 ± 1.061
4.677AlaLeu: 4.677 ± 0.549
0.825AlaMet: 0.825 ± 0.393
4.127AlaAsn: 4.127 ± 1.379
1.926AlaPro: 1.926 ± 0.686
1.376AlaGln: 1.376 ± 0.401
1.926AlaArg: 1.926 ± 1.142
3.851AlaSer: 3.851 ± 1.215
3.851AlaThr: 3.851 ± 0.803
4.677AlaVal: 4.677 ± 0.839
0.55AlaTrp: 0.55 ± 0.346
1.1AlaTyr: 1.1 ± 0.593
0.0AlaXaa: 0.0 ± 0.0
Cys
0.275CysAla: 0.275 ± 0.237
0.55CysCys: 0.55 ± 0.339
1.1CysAsp: 1.1 ± 0.466
0.55CysGlu: 0.55 ± 0.325
0.825CysPhe: 0.825 ± 0.387
0.0CysGly: 0.0 ± 0.0
0.0CysHis: 0.0 ± 0.0
0.55CysIle: 0.55 ± 0.359
1.926CysLys: 1.926 ± 0.916
1.1CysLeu: 1.1 ± 0.666
0.825CysMet: 0.825 ± 0.465
1.376CysAsn: 1.376 ± 0.664
0.275CysPro: 0.275 ± 0.243
0.825CysGln: 0.825 ± 0.53
0.825CysArg: 0.825 ± 0.751
1.926CysSer: 1.926 ± 1.192
1.1CysThr: 1.1 ± 0.683
1.1CysVal: 1.1 ± 0.351
0.0CysTrp: 0.0 ± 0.0
0.55CysTyr: 0.55 ± 0.329
0.0CysXaa: 0.0 ± 0.0
Asp
4.402AspAla: 4.402 ± 1.102
0.825AspCys: 0.825 ± 0.497
5.227AspAsp: 5.227 ± 1.399
3.576AspGlu: 3.576 ± 0.882
2.751AspPhe: 2.751 ± 0.683
2.201AspGly: 2.201 ± 0.632
1.376AspHis: 1.376 ± 0.547
4.127AspIle: 4.127 ± 1.21
4.952AspLys: 4.952 ± 0.965
3.301AspLeu: 3.301 ± 0.722
3.026AspMet: 3.026 ± 0.899
3.576AspAsn: 3.576 ± 0.96
2.201AspPro: 2.201 ± 0.782
3.026AspGln: 3.026 ± 0.965
2.201AspArg: 2.201 ± 0.626
5.227AspSer: 5.227 ± 1.943
3.576AspThr: 3.576 ± 1.041
6.052AspVal: 6.052 ± 1.203
0.55AspTrp: 0.55 ± 0.412
4.127AspTyr: 4.127 ± 1.027
0.0AspXaa: 0.0 ± 0.0
Glu
2.476GluAla: 2.476 ± 0.763
0.275GluCys: 0.275 ± 0.27
3.026GluAsp: 3.026 ± 0.809
1.926GluGlu: 1.926 ± 0.931
1.651GluPhe: 1.651 ± 0.64
1.376GluGly: 1.376 ± 0.472
0.55GluHis: 0.55 ± 0.34
4.127GluIle: 4.127 ± 1.38
3.851GluLys: 3.851 ± 0.965
6.052GluLeu: 6.052 ± 1.378
3.576GluMet: 3.576 ± 0.774
4.127GluAsn: 4.127 ± 0.768
1.926GluPro: 1.926 ± 0.975
1.926GluGln: 1.926 ± 0.976
2.751GluArg: 2.751 ± 0.725
3.576GluSer: 3.576 ± 0.903
2.751GluThr: 2.751 ± 1.04
4.677GluVal: 4.677 ± 0.652
1.651GluTrp: 1.651 ± 0.565
5.502GluTyr: 5.502 ± 1.167
0.0GluXaa: 0.0 ± 0.0
Phe
1.651PheAla: 1.651 ± 0.639
0.275PheCys: 0.275 ± 0.242
2.476PheAsp: 2.476 ± 1.084
2.751PheGlu: 2.751 ± 0.786
0.825PhePhe: 0.825 ± 0.402
1.376PheGly: 1.376 ± 0.517
1.376PheHis: 1.376 ± 0.513
3.851PheIle: 3.851 ± 0.918
2.751PheLys: 2.751 ± 0.82
4.127PheLeu: 4.127 ± 1.021
0.275PheMet: 0.275 ± 0.25
2.751PheAsn: 2.751 ± 0.792
2.201PhePro: 2.201 ± 1.069
2.201PheGln: 2.201 ± 0.787
1.651PheArg: 1.651 ± 0.515
3.851PheSer: 3.851 ± 0.955
3.576PheThr: 3.576 ± 1.073
1.1PheVal: 1.1 ± 0.419
0.275PheTrp: 0.275 ± 0.233
1.376PheTyr: 1.376 ± 0.434
0.0PheXaa: 0.0 ± 0.0
Gly
0.825GlyAla: 0.825 ± 0.326
0.825GlyCys: 0.825 ± 0.408
1.1GlyAsp: 1.1 ± 0.68
2.476GlyGlu: 2.476 ± 0.894
1.1GlyPhe: 1.1 ± 0.506
1.1GlyGly: 1.1 ± 0.458
0.825GlyHis: 0.825 ± 0.384
3.026GlyIle: 3.026 ± 0.756
3.026GlyLys: 3.026 ± 1.2
2.476GlyLeu: 2.476 ± 0.852
0.825GlyMet: 0.825 ± 0.465
1.926GlyAsn: 1.926 ± 0.608
1.651GlyPro: 1.651 ± 0.628
0.825GlyGln: 0.825 ± 0.381
2.476GlyArg: 2.476 ± 1.182
2.201GlySer: 2.201 ± 0.872
1.926GlyThr: 1.926 ± 0.921
2.476GlyVal: 2.476 ± 0.541
0.825GlyTrp: 0.825 ± 0.37
0.825GlyTyr: 0.825 ± 0.408
0.0GlyXaa: 0.0 ± 0.0
His
1.926HisAla: 1.926 ± 0.489
0.275HisCys: 0.275 ± 0.25
1.651HisAsp: 1.651 ± 0.561
0.275HisGlu: 0.275 ± 0.233
0.275HisPhe: 0.275 ± 0.25
1.376HisGly: 1.376 ± 0.837
0.55HisHis: 0.55 ± 0.331
0.825HisIle: 0.825 ± 0.548
2.476HisLys: 2.476 ± 0.578
1.376HisLeu: 1.376 ± 0.626
0.0HisMet: 0.0 ± 0.0
1.1HisAsn: 1.1 ± 0.461
0.275HisPro: 0.275 ± 0.242
0.825HisGln: 0.825 ± 0.497
0.275HisArg: 0.275 ± 0.25
1.376HisSer: 1.376 ± 0.591
1.1HisThr: 1.1 ± 0.391
1.1HisVal: 1.1 ± 0.479
0.275HisTrp: 0.275 ± 0.274
0.825HisTyr: 0.825 ± 0.393
0.0HisXaa: 0.0 ± 0.0
Ile
5.227IleAla: 5.227 ± 1.064
0.55IleCys: 0.55 ± 0.307
5.777IleAsp: 5.777 ± 1.443
4.402IleGlu: 4.402 ± 0.911
2.476IlePhe: 2.476 ± 0.879
2.201IleGly: 2.201 ± 0.619
1.1IleHis: 1.1 ± 0.47
5.227IleIle: 5.227 ± 0.923
4.952IleLys: 4.952 ± 0.856
6.052IleLeu: 6.052 ± 1.438
0.55IleMet: 0.55 ± 0.35
6.878IleAsn: 6.878 ± 1.177
3.026IlePro: 3.026 ± 0.859
3.301IleGln: 3.301 ± 0.765
4.402IleArg: 4.402 ± 0.909
3.026IleSer: 3.026 ± 1.111
5.227IleThr: 5.227 ± 0.879
4.677IleVal: 4.677 ± 1.005
0.55IleTrp: 0.55 ± 0.354
2.201IleTyr: 2.201 ± 0.966
0.0IleXaa: 0.0 ± 0.0
Lys
1.926LysAla: 1.926 ± 0.675
2.476LysCys: 2.476 ± 0.686
4.402LysAsp: 4.402 ± 0.754
5.227LysGlu: 5.227 ± 1.651
2.476LysPhe: 2.476 ± 0.604
2.476LysGly: 2.476 ± 0.722
1.376LysHis: 1.376 ± 0.574
4.677LysIle: 4.677 ± 0.84
6.052LysLys: 6.052 ± 1.455
8.528LysLeu: 8.528 ± 1.588
2.201LysMet: 2.201 ± 0.786
3.851LysAsn: 3.851 ± 0.918
1.926LysPro: 1.926 ± 0.364
4.127LysGln: 4.127 ± 0.897
2.476LysArg: 2.476 ± 0.589
4.402LysSer: 4.402 ± 1.126
3.851LysThr: 3.851 ± 0.606
4.402LysVal: 4.402 ± 1.031
1.651LysTrp: 1.651 ± 0.87
3.576LysTyr: 3.576 ± 1.252
0.0LysXaa: 0.0 ± 0.0
Leu
4.402LeuAla: 4.402 ± 1.361
0.55LeuCys: 0.55 ± 0.486
6.602LeuAsp: 6.602 ± 1.132
5.502LeuGlu: 5.502 ± 1.331
4.402LeuPhe: 4.402 ± 0.624
2.201LeuGly: 2.201 ± 0.579
1.651LeuHis: 1.651 ± 0.861
5.777LeuIle: 5.777 ± 0.697
5.227LeuLys: 5.227 ± 0.891
7.978LeuLeu: 7.978 ± 1.247
3.851LeuMet: 3.851 ± 0.913
7.428LeuAsn: 7.428 ± 1.276
3.851LeuPro: 3.851 ± 0.977
3.026LeuGln: 3.026 ± 0.992
4.952LeuArg: 4.952 ± 1.09
7.703LeuSer: 7.703 ± 1.784
5.227LeuThr: 5.227 ± 1.033
4.677LeuVal: 4.677 ± 1.078
0.275LeuTrp: 0.275 ± 0.242
2.751LeuTyr: 2.751 ± 0.744
0.0LeuXaa: 0.0 ± 0.0
Met
1.651MetAla: 1.651 ± 0.508
0.55MetCys: 0.55 ± 0.329
4.127MetAsp: 4.127 ± 0.828
1.376MetGlu: 1.376 ± 0.827
1.376MetPhe: 1.376 ± 0.401
1.1MetGly: 1.1 ± 0.353
0.275MetHis: 0.275 ± 0.233
1.376MetIle: 1.376 ± 0.73
2.476MetLys: 2.476 ± 0.651
3.851MetLeu: 3.851 ± 1.181
0.825MetMet: 0.825 ± 0.407
2.201MetAsn: 2.201 ± 0.908
0.825MetPro: 0.825 ± 0.383
0.55MetGln: 0.55 ± 0.371
2.201MetArg: 2.201 ± 0.666
2.751MetSer: 2.751 ± 1.057
0.825MetThr: 0.825 ± 0.326
1.1MetVal: 1.1 ± 0.386
0.55MetTrp: 0.55 ± 0.325
1.651MetTyr: 1.651 ± 0.703
0.0MetXaa: 0.0 ± 0.0
Asn
4.402AsnAla: 4.402 ± 1.072
1.1AsnCys: 1.1 ± 0.584
4.127AsnAsp: 4.127 ± 1.024
6.052AsnGlu: 6.052 ± 1.142
2.476AsnPhe: 2.476 ± 0.877
2.476AsnGly: 2.476 ± 0.718
1.926AsnHis: 1.926 ± 0.88
4.952AsnIle: 4.952 ± 1.497
4.677AsnLys: 4.677 ± 0.959
7.428AsnLeu: 7.428 ± 0.921
1.926AsnMet: 1.926 ± 0.597
3.301AsnAsn: 3.301 ± 0.637
2.201AsnPro: 2.201 ± 0.613
2.476AsnGln: 2.476 ± 0.578
2.201AsnArg: 2.201 ± 0.412
5.227AsnSer: 5.227 ± 0.893
3.026AsnThr: 3.026 ± 0.8
4.952AsnVal: 4.952 ± 0.721
1.651AsnTrp: 1.651 ± 0.761
4.402AsnTyr: 4.402 ± 0.826
0.0AsnXaa: 0.0 ± 0.0
Pro
0.825ProAla: 0.825 ± 0.474
0.0ProCys: 0.0 ± 0.0
1.651ProAsp: 1.651 ± 0.475
0.825ProGlu: 0.825 ± 0.536
1.926ProPhe: 1.926 ± 0.506
2.201ProGly: 2.201 ± 0.475
0.825ProHis: 0.825 ± 0.399
3.576ProIle: 3.576 ± 0.706
0.825ProLys: 0.825 ± 0.403
1.926ProLeu: 1.926 ± 0.593
1.1ProMet: 1.1 ± 0.403
2.476ProAsn: 2.476 ± 0.914
1.926ProPro: 1.926 ± 0.652
1.651ProGln: 1.651 ± 0.684
1.926ProArg: 1.926 ± 0.47
2.476ProSer: 2.476 ± 0.891
2.201ProThr: 2.201 ± 0.936
2.751ProVal: 2.751 ± 0.839
0.0ProTrp: 0.0 ± 0.0
2.201ProTyr: 2.201 ± 0.686
0.0ProXaa: 0.0 ± 0.0
Gln
1.376GlnAla: 1.376 ± 0.628
0.275GlnCys: 0.275 ± 0.27
1.926GlnAsp: 1.926 ± 0.848
2.476GlnGlu: 2.476 ± 0.519
1.376GlnPhe: 1.376 ± 0.672
0.275GlnGly: 0.275 ± 0.242
1.926GlnHis: 1.926 ± 0.545
2.751GlnIle: 2.751 ± 0.709
2.476GlnLys: 2.476 ± 0.795
4.402GlnLeu: 4.402 ± 1.123
1.1GlnMet: 1.1 ± 0.474
3.026GlnAsn: 3.026 ± 1.027
1.1GlnPro: 1.1 ± 0.506
4.402GlnGln: 4.402 ± 1.368
1.651GlnArg: 1.651 ± 0.74
2.476GlnSer: 2.476 ± 0.511
3.576GlnThr: 3.576 ± 0.842
3.026GlnVal: 3.026 ± 0.981
0.825GlnTrp: 0.825 ± 0.497
2.751GlnTyr: 2.751 ± 0.68
0.0GlnXaa: 0.0 ± 0.0
Arg
1.1ArgAla: 1.1 ± 0.372
1.1ArgCys: 1.1 ± 0.496
1.651ArgAsp: 1.651 ± 0.622
2.476ArgGlu: 2.476 ± 0.771
2.201ArgPhe: 2.201 ± 0.454
1.376ArgGly: 1.376 ± 0.649
1.1ArgHis: 1.1 ± 0.488
3.576ArgIle: 3.576 ± 0.719
3.301ArgLys: 3.301 ± 0.846
1.926ArgLeu: 1.926 ± 0.474
2.476ArgMet: 2.476 ± 0.802
3.576ArgAsn: 3.576 ± 1.114
2.201ArgPro: 2.201 ± 0.661
2.476ArgGln: 2.476 ± 0.644
1.926ArgArg: 1.926 ± 0.781
2.476ArgSer: 2.476 ± 0.772
3.301ArgThr: 3.301 ± 0.727
3.026ArgVal: 3.026 ± 1.114
0.825ArgTrp: 0.825 ± 0.358
1.651ArgTyr: 1.651 ± 0.446
0.0ArgXaa: 0.0 ± 0.0
Ser
2.751SerAla: 2.751 ± 0.788
0.825SerCys: 0.825 ± 0.394
3.301SerAsp: 3.301 ± 1.038
3.851SerGlu: 3.851 ± 0.989
3.851SerPhe: 3.851 ± 0.763
1.926SerGly: 1.926 ± 0.49
1.376SerHis: 1.376 ± 0.536
6.327SerIle: 6.327 ± 1.598
6.052SerLys: 6.052 ± 0.64
4.677SerLeu: 4.677 ± 1.111
4.127SerMet: 4.127 ± 0.643
5.502SerAsn: 5.502 ± 1.459
1.651SerPro: 1.651 ± 0.571
3.851SerGln: 3.851 ± 0.638
3.301SerArg: 3.301 ± 0.627
6.878SerSer: 6.878 ± 1.744
5.227SerThr: 5.227 ± 1.095
4.952SerVal: 4.952 ± 1.019
0.55SerTrp: 0.55 ± 0.308
3.026SerTyr: 3.026 ± 1.257
0.0SerXaa: 0.0 ± 0.0
Thr
3.851ThrAla: 3.851 ± 0.947
0.55ThrCys: 0.55 ± 0.328
4.952ThrAsp: 4.952 ± 1.098
2.476ThrGlu: 2.476 ± 0.608
3.851ThrPhe: 3.851 ± 0.768
1.651ThrGly: 1.651 ± 0.664
0.825ThrHis: 0.825 ± 0.575
4.952ThrIle: 4.952 ± 1.266
3.576ThrLys: 3.576 ± 0.827
8.803ThrLeu: 8.803 ± 2.09
1.926ThrMet: 1.926 ± 0.699
3.301ThrAsn: 3.301 ± 1.335
1.651ThrPro: 1.651 ± 0.366
2.751ThrGln: 2.751 ± 0.688
3.026ThrArg: 3.026 ± 0.751
5.502ThrSer: 5.502 ± 1.005
6.052ThrThr: 6.052 ± 1.505
2.751ThrVal: 2.751 ± 0.951
1.1ThrTrp: 1.1 ± 0.386
2.201ThrTyr: 2.201 ± 0.923
0.0ThrXaa: 0.0 ± 0.0
Val
4.952ValAla: 4.952 ± 0.935
1.926ValCys: 1.926 ± 0.67
4.677ValAsp: 4.677 ± 1.201
5.227ValGlu: 5.227 ± 1.265
2.751ValPhe: 2.751 ± 0.81
3.301ValGly: 3.301 ± 0.509
0.55ValHis: 0.55 ± 0.339
4.677ValIle: 4.677 ± 0.853
4.952ValLys: 4.952 ± 1.18
5.227ValLeu: 5.227 ± 0.855
1.376ValMet: 1.376 ± 0.803
5.777ValAsn: 5.777 ± 1.298
1.1ValPro: 1.1 ± 0.931
1.926ValGln: 1.926 ± 0.398
1.926ValArg: 1.926 ± 0.455
3.301ValSer: 3.301 ± 0.472
5.227ValThr: 5.227 ± 0.98
3.301ValVal: 3.301 ± 0.742
0.275ValTrp: 0.275 ± 0.25
1.926ValTyr: 1.926 ± 0.594
0.0ValXaa: 0.0 ± 0.0
Trp
0.275TrpAla: 0.275 ± 0.233
0.825TrpCys: 0.825 ± 0.751
0.825TrpAsp: 0.825 ± 0.337
0.275TrpGlu: 0.275 ± 0.308
0.275TrpPhe: 0.275 ± 0.237
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
0.825TrpIle: 0.825 ± 0.417
2.201TrpLys: 2.201 ± 0.751
1.376TrpLeu: 1.376 ± 0.442
0.275TrpMet: 0.275 ± 0.27
1.1TrpAsn: 1.1 ± 0.781
0.275TrpPro: 0.275 ± 0.243
0.825TrpGln: 0.825 ± 0.549
0.55TrpArg: 0.55 ± 0.339
0.55TrpSer: 0.55 ± 0.343
0.825TrpThr: 0.825 ± 0.515
0.825TrpVal: 0.825 ± 0.467
0.275TrpTrp: 0.275 ± 0.243
1.1TrpTyr: 1.1 ± 0.418
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.476TyrAla: 2.476 ± 0.78
1.1TyrCys: 1.1 ± 0.446
3.301TyrAsp: 3.301 ± 1.025
3.301TyrGlu: 3.301 ± 0.822
2.476TyrPhe: 2.476 ± 0.716
1.926TyrGly: 1.926 ± 0.746
0.275TyrHis: 0.275 ± 0.25
3.576TyrIle: 3.576 ± 0.964
3.301TyrLys: 3.301 ± 0.957
2.751TyrLeu: 2.751 ± 1.304
0.55TyrMet: 0.55 ± 0.344
3.576TyrAsn: 3.576 ± 0.991
1.1TyrPro: 1.1 ± 0.443
0.825TyrGln: 0.825 ± 0.402
1.1TyrArg: 1.1 ± 0.393
5.227TyrSer: 5.227 ± 1.445
3.301TyrThr: 3.301 ± 1.299
2.751TyrVal: 2.751 ± 0.544
0.825TyrTrp: 0.825 ± 0.436
3.301TyrTyr: 3.301 ± 1.299
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 11 proteins (3636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski