Amino acid dipepetide frequency for Halorubrum pleomorphic virus 9

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.58AlaAla: 10.58 ± 2.154
0.61AlaCys: 0.61 ± 0.339
5.697AlaAsp: 5.697 ± 1.289
5.29AlaGlu: 5.29 ± 1.008
1.831AlaPhe: 1.831 ± 0.588
9.563AlaGly: 9.563 ± 1.736
1.424AlaHis: 1.424 ± 0.543
6.307AlaIle: 6.307 ± 1.602
1.831AlaLys: 1.831 ± 0.505
6.511AlaLeu: 6.511 ± 1.324
2.645AlaMet: 2.645 ± 0.914
2.848AlaAsn: 2.848 ± 0.602
2.645AlaPro: 2.645 ± 0.649
2.238AlaGln: 2.238 ± 0.618
5.697AlaArg: 5.697 ± 1.121
5.29AlaSer: 5.29 ± 1.068
5.493AlaThr: 5.493 ± 1.138
10.987AlaVal: 10.987 ± 1.471
2.035AlaTrp: 2.035 ± 0.79
3.662AlaTyr: 3.662 ± 1.079
0.0AlaXaa: 0.0 ± 0.0
Cys
0.407CysAla: 0.407 ± 0.267
0.203CysCys: 0.203 ± 0.212
0.0CysAsp: 0.0 ± 0.0
1.017CysGlu: 1.017 ± 0.526
0.0CysPhe: 0.0 ± 0.0
0.203CysGly: 0.203 ± 0.212
0.0CysHis: 0.0 ± 0.0
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.203CysLeu: 0.203 ± 0.228
0.203CysMet: 0.203 ± 0.195
0.0CysAsn: 0.0 ± 0.0
0.814CysPro: 0.814 ± 0.534
0.61CysGln: 0.61 ± 0.347
0.61CysArg: 0.61 ± 0.329
0.203CysSer: 0.203 ± 0.228
0.0CysThr: 0.0 ± 0.0
0.407CysVal: 0.407 ± 0.363
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
8.342AspAla: 8.342 ± 1.218
0.0AspCys: 0.0 ± 0.0
5.493AspAsp: 5.493 ± 1.104
7.325AspGlu: 7.325 ± 1.808
0.61AspPhe: 0.61 ± 0.393
7.528AspGly: 7.528 ± 1.695
1.424AspHis: 1.424 ± 0.768
2.442AspIle: 2.442 ± 0.839
1.221AspLys: 1.221 ± 0.359
5.086AspLeu: 5.086 ± 1.171
1.017AspMet: 1.017 ± 0.494
1.221AspAsn: 1.221 ± 0.454
4.273AspPro: 4.273 ± 1.099
2.238AspGln: 2.238 ± 0.787
6.918AspArg: 6.918 ± 1.733
4.069AspSer: 4.069 ± 1.201
3.255AspThr: 3.255 ± 0.833
4.069AspVal: 4.069 ± 0.738
1.017AspTrp: 1.017 ± 0.416
1.831AspTyr: 1.831 ± 0.599
0.0AspXaa: 0.0 ± 0.0
Glu
7.325GluAla: 7.325 ± 1.622
0.814GluCys: 0.814 ± 0.448
4.883GluAsp: 4.883 ± 1.571
5.493GluGlu: 5.493 ± 1.196
2.035GluPhe: 2.035 ± 0.599
4.883GluGly: 4.883 ± 1.054
1.628GluHis: 1.628 ± 0.611
4.069GluIle: 4.069 ± 0.835
2.035GluLys: 2.035 ± 0.55
8.138GluLeu: 8.138 ± 1.072
1.628GluMet: 1.628 ± 0.536
2.035GluAsn: 2.035 ± 0.646
2.645GluPro: 2.645 ± 0.874
2.848GluGln: 2.848 ± 0.589
5.493GluArg: 5.493 ± 1.215
7.528GluSer: 7.528 ± 1.68
6.918GluThr: 6.918 ± 0.841
4.069GluVal: 4.069 ± 0.835
1.424GluTrp: 1.424 ± 0.446
1.831GluTyr: 1.831 ± 0.459
0.0GluXaa: 0.0 ± 0.0
Phe
2.442PheAla: 2.442 ± 0.598
0.407PheCys: 0.407 ± 0.261
2.442PheAsp: 2.442 ± 0.643
3.662PheGlu: 3.662 ± 0.88
0.61PhePhe: 0.61 ± 0.363
3.052PheGly: 3.052 ± 0.944
0.407PheHis: 0.407 ± 0.28
1.424PheIle: 1.424 ± 0.628
0.61PheLys: 0.61 ± 0.346
2.238PheLeu: 2.238 ± 0.875
0.407PheMet: 0.407 ± 0.278
0.61PheAsn: 0.61 ± 0.373
0.407PhePro: 0.407 ± 0.285
0.814PheGln: 0.814 ± 0.569
0.61PheArg: 0.61 ± 0.413
1.628PheSer: 1.628 ± 0.734
1.831PheThr: 1.831 ± 0.553
3.052PheVal: 3.052 ± 0.907
0.407PheTrp: 0.407 ± 0.301
0.61PheTyr: 0.61 ± 0.356
0.0PheXaa: 0.0 ± 0.0
Gly
7.731GlyAla: 7.731 ± 1.662
0.0GlyCys: 0.0 ± 0.0
5.29GlyAsp: 5.29 ± 0.936
5.493GlyGlu: 5.493 ± 1.136
2.442GlyPhe: 2.442 ± 0.879
8.342GlyGly: 8.342 ± 1.246
1.017GlyHis: 1.017 ± 0.405
4.069GlyIle: 4.069 ± 0.942
2.035GlyLys: 2.035 ± 0.612
10.376GlyLeu: 10.376 ± 1.215
0.814GlyMet: 0.814 ± 0.469
2.645GlyAsn: 2.645 ± 0.824
3.459GlyPro: 3.459 ± 0.784
2.442GlyGln: 2.442 ± 0.656
4.883GlyArg: 4.883 ± 1.312
8.545GlySer: 8.545 ± 1.325
4.069GlyThr: 4.069 ± 1.373
6.307GlyVal: 6.307 ± 1.144
1.017GlyTrp: 1.017 ± 0.553
2.848GlyTyr: 2.848 ± 0.677
0.0GlyXaa: 0.0 ± 0.0
His
1.424HisAla: 1.424 ± 0.638
0.203HisCys: 0.203 ± 0.19
0.814HisAsp: 0.814 ± 0.408
1.424HisGlu: 1.424 ± 0.616
0.814HisPhe: 0.814 ± 0.448
1.424HisGly: 1.424 ± 0.684
0.61HisHis: 0.61 ± 0.291
0.61HisIle: 0.61 ± 0.364
0.407HisLys: 0.407 ± 0.309
1.424HisLeu: 1.424 ± 0.564
0.0HisMet: 0.0 ± 0.0
0.203HisAsn: 0.203 ± 0.195
1.628HisPro: 1.628 ± 0.628
0.203HisGln: 0.203 ± 0.201
1.017HisArg: 1.017 ± 0.475
0.61HisSer: 0.61 ± 0.306
1.017HisThr: 1.017 ± 0.417
0.814HisVal: 0.814 ± 0.345
0.0HisTrp: 0.0 ± 0.0
1.424HisTyr: 1.424 ± 0.632
0.0HisXaa: 0.0 ± 0.0
Ile
4.476IleAla: 4.476 ± 0.644
0.203IleCys: 0.203 ± 0.228
3.662IleAsp: 3.662 ± 0.706
4.476IleGlu: 4.476 ± 1.197
1.831IlePhe: 1.831 ± 0.728
3.866IleGly: 3.866 ± 0.921
1.628IleHis: 1.628 ± 0.604
1.424IleIle: 1.424 ± 0.685
1.017IleLys: 1.017 ± 0.47
4.476IleLeu: 4.476 ± 0.966
0.61IleMet: 0.61 ± 0.595
1.831IleAsn: 1.831 ± 0.68
2.238IlePro: 2.238 ± 0.647
1.628IleGln: 1.628 ± 0.596
3.459IleArg: 3.459 ± 1.079
3.459IleSer: 3.459 ± 1.049
3.459IleThr: 3.459 ± 1.172
3.662IleVal: 3.662 ± 1.039
0.61IleTrp: 0.61 ± 0.437
1.628IleTyr: 1.628 ± 0.705
0.0IleXaa: 0.0 ± 0.0
Lys
1.831LysAla: 1.831 ± 0.682
0.407LysCys: 0.407 ± 0.267
1.221LysAsp: 1.221 ± 0.465
1.628LysGlu: 1.628 ± 0.719
0.61LysPhe: 0.61 ± 0.517
1.628LysGly: 1.628 ± 0.513
0.61LysHis: 0.61 ± 0.263
2.442LysIle: 2.442 ± 0.821
0.203LysLys: 0.203 ± 0.219
1.424LysLeu: 1.424 ± 0.612
0.407LysMet: 0.407 ± 0.282
0.61LysAsn: 0.61 ± 0.298
0.61LysPro: 0.61 ± 0.333
1.424LysGln: 1.424 ± 0.469
3.255LysArg: 3.255 ± 0.82
3.255LysSer: 3.255 ± 0.975
2.645LysThr: 2.645 ± 0.685
1.831LysVal: 1.831 ± 0.61
0.407LysTrp: 0.407 ± 0.244
0.203LysTyr: 0.203 ± 0.191
0.0LysXaa: 0.0 ± 0.0
Leu
9.563LeuAla: 9.563 ± 1.469
0.203LeuCys: 0.203 ± 0.212
7.121LeuAsp: 7.121 ± 1.487
6.307LeuGlu: 6.307 ± 1.325
3.459LeuPhe: 3.459 ± 0.912
4.68LeuGly: 4.68 ± 0.948
0.814LeuHis: 0.814 ± 0.51
3.459LeuIle: 3.459 ± 0.629
4.069LeuLys: 4.069 ± 1.005
6.714LeuLeu: 6.714 ± 1.183
1.017LeuMet: 1.017 ± 0.382
2.848LeuAsn: 2.848 ± 1.015
3.052LeuPro: 3.052 ± 0.786
1.221LeuGln: 1.221 ± 0.503
5.493LeuArg: 5.493 ± 1.081
6.918LeuSer: 6.918 ± 1.704
5.29LeuThr: 5.29 ± 1.053
9.563LeuVal: 9.563 ± 2.164
0.814LeuTrp: 0.814 ± 0.398
1.424LeuTyr: 1.424 ± 0.531
0.0LeuXaa: 0.0 ± 0.0
Met
1.017MetAla: 1.017 ± 0.636
0.0MetCys: 0.0 ± 0.0
0.407MetAsp: 0.407 ± 0.306
1.017MetGlu: 1.017 ± 0.467
0.814MetPhe: 0.814 ± 0.412
1.424MetGly: 1.424 ± 0.675
0.0MetHis: 0.0 ± 0.0
0.61MetIle: 0.61 ± 0.464
0.814MetLys: 0.814 ± 0.357
1.628MetLeu: 1.628 ± 0.599
0.0MetMet: 0.0 ± 0.0
0.814MetAsn: 0.814 ± 0.51
0.61MetPro: 0.61 ± 0.325
0.0MetGln: 0.0 ± 0.0
0.814MetArg: 0.814 ± 0.391
2.645MetSer: 2.645 ± 0.912
1.424MetThr: 1.424 ± 0.486
1.017MetVal: 1.017 ± 0.458
0.203MetTrp: 0.203 ± 0.18
1.221MetTyr: 1.221 ± 0.609
0.0MetXaa: 0.0 ± 0.0
Asn
3.459AsnAla: 3.459 ± 1.12
0.0AsnCys: 0.0 ± 0.0
1.628AsnAsp: 1.628 ± 0.558
1.221AsnGlu: 1.221 ± 0.656
0.203AsnPhe: 0.203 ± 0.191
2.848AsnGly: 2.848 ± 0.837
0.407AsnHis: 0.407 ± 0.292
1.017AsnIle: 1.017 ± 0.508
1.221AsnLys: 1.221 ± 0.697
2.442AsnLeu: 2.442 ± 0.816
0.0AsnMet: 0.0 ± 0.0
0.61AsnAsn: 0.61 ± 0.332
2.035AsnPro: 2.035 ± 0.56
1.628AsnGln: 1.628 ± 0.803
1.628AsnArg: 1.628 ± 0.647
2.035AsnSer: 2.035 ± 0.741
2.848AsnThr: 2.848 ± 0.734
2.645AsnVal: 2.645 ± 0.799
1.017AsnTrp: 1.017 ± 0.426
1.831AsnTyr: 1.831 ± 0.527
0.0AsnXaa: 0.0 ± 0.0
Pro
3.662ProAla: 3.662 ± 0.916
0.407ProCys: 0.407 ± 0.255
3.255ProAsp: 3.255 ± 0.99
2.848ProGlu: 2.848 ± 0.599
0.61ProPhe: 0.61 ± 0.302
3.052ProGly: 3.052 ± 0.856
0.814ProHis: 0.814 ± 0.432
2.645ProIle: 2.645 ± 0.854
2.238ProLys: 2.238 ± 0.753
2.238ProLeu: 2.238 ± 0.893
1.017ProMet: 1.017 ± 0.467
1.831ProAsn: 1.831 ± 0.56
2.645ProPro: 2.645 ± 0.896
1.628ProGln: 1.628 ± 0.654
3.662ProArg: 3.662 ± 0.877
2.848ProSer: 2.848 ± 0.834
2.645ProThr: 2.645 ± 0.747
3.866ProVal: 3.866 ± 0.926
0.814ProTrp: 0.814 ± 0.4
1.221ProTyr: 1.221 ± 0.405
0.0ProXaa: 0.0 ± 0.0
Gln
1.017GlnAla: 1.017 ± 0.323
0.0GlnCys: 0.0 ± 0.0
1.221GlnAsp: 1.221 ± 0.505
1.831GlnGlu: 1.831 ± 0.546
2.238GlnPhe: 2.238 ± 0.653
2.238GlnGly: 2.238 ± 0.777
1.424GlnHis: 1.424 ± 0.581
1.424GlnIle: 1.424 ± 0.696
0.407GlnLys: 0.407 ± 0.28
2.035GlnLeu: 2.035 ± 0.455
0.407GlnMet: 0.407 ± 0.295
1.221GlnAsn: 1.221 ± 0.62
1.831GlnPro: 1.831 ± 0.717
0.61GlnGln: 0.61 ± 0.416
2.035GlnArg: 2.035 ± 0.642
2.645GlnSer: 2.645 ± 0.638
3.255GlnThr: 3.255 ± 0.852
2.035GlnVal: 2.035 ± 0.598
0.0GlnTrp: 0.0 ± 0.0
1.221GlnTyr: 1.221 ± 0.541
0.0GlnXaa: 0.0 ± 0.0
Arg
5.29ArgAla: 5.29 ± 1.241
0.0ArgCys: 0.0 ± 0.0
5.086ArgAsp: 5.086 ± 1.195
7.528ArgGlu: 7.528 ± 1.187
1.221ArgPhe: 1.221 ± 0.585
5.9ArgGly: 5.9 ± 1.154
0.814ArgHis: 0.814 ± 0.403
3.866ArgIle: 3.866 ± 0.988
2.442ArgLys: 2.442 ± 0.598
5.9ArgLeu: 5.9 ± 0.983
1.628ArgMet: 1.628 ± 0.477
2.442ArgAsn: 2.442 ± 0.824
3.866ArgPro: 3.866 ± 0.832
2.035ArgGln: 2.035 ± 0.456
7.121ArgArg: 7.121 ± 1.376
4.883ArgSer: 4.883 ± 0.909
4.069ArgThr: 4.069 ± 1.164
6.104ArgVal: 6.104 ± 1.411
1.424ArgTrp: 1.424 ± 0.663
1.831ArgTyr: 1.831 ± 0.696
0.0ArgXaa: 0.0 ± 0.0
Ser
4.68SerAla: 4.68 ± 0.876
0.0SerCys: 0.0 ± 0.0
4.476SerAsp: 4.476 ± 1.241
6.307SerGlu: 6.307 ± 1.056
2.645SerPhe: 2.645 ± 0.825
7.731SerGly: 7.731 ± 1.312
1.424SerHis: 1.424 ± 0.511
4.273SerIle: 4.273 ± 0.979
2.645SerLys: 2.645 ± 0.905
5.086SerLeu: 5.086 ± 1.111
1.628SerMet: 1.628 ± 0.536
1.831SerAsn: 1.831 ± 0.5
2.645SerPro: 2.645 ± 0.794
2.035SerGln: 2.035 ± 0.652
5.29SerArg: 5.29 ± 1.203
5.086SerSer: 5.086 ± 1.564
4.476SerThr: 4.476 ± 1.207
8.138SerVal: 8.138 ± 1.039
1.221SerTrp: 1.221 ± 0.456
1.628SerTyr: 1.628 ± 0.678
0.0SerXaa: 0.0 ± 0.0
Thr
5.697ThrAla: 5.697 ± 1.643
0.407ThrCys: 0.407 ± 0.343
4.273ThrAsp: 4.273 ± 1.072
5.493ThrGlu: 5.493 ± 1.113
1.424ThrPhe: 1.424 ± 0.402
4.476ThrGly: 4.476 ± 0.987
1.017ThrHis: 1.017 ± 0.48
5.493ThrIle: 5.493 ± 1.293
0.814ThrLys: 0.814 ± 0.626
6.918ThrLeu: 6.918 ± 1.246
1.017ThrMet: 1.017 ± 0.444
2.848ThrAsn: 2.848 ± 0.866
3.255ThrPro: 3.255 ± 0.648
1.831ThrGln: 1.831 ± 0.677
3.866ThrArg: 3.866 ± 0.727
3.255ThrSer: 3.255 ± 0.635
4.069ThrThr: 4.069 ± 1.256
7.121ThrVal: 7.121 ± 1.401
0.61ThrTrp: 0.61 ± 0.393
1.221ThrTyr: 1.221 ± 0.479
0.0ThrXaa: 0.0 ± 0.0
Val
11.801ValAla: 11.801 ± 2.01
0.61ValCys: 0.61 ± 0.32
8.138ValAsp: 8.138 ± 1.059
6.918ValGlu: 6.918 ± 1.408
3.255ValPhe: 3.255 ± 1.002
7.935ValGly: 7.935 ± 1.356
0.203ValHis: 0.203 ± 0.157
2.442ValIle: 2.442 ± 1.038
1.831ValLys: 1.831 ± 0.961
6.511ValLeu: 6.511 ± 1.177
1.017ValMet: 1.017 ± 0.615
2.848ValAsn: 2.848 ± 0.88
3.255ValPro: 3.255 ± 0.962
2.035ValGln: 2.035 ± 0.676
7.121ValArg: 7.121 ± 1.471
6.104ValSer: 6.104 ± 0.83
6.511ValThr: 6.511 ± 1.129
10.376ValVal: 10.376 ± 1.271
0.407ValTrp: 0.407 ± 0.274
2.035ValTyr: 2.035 ± 0.802
0.0ValXaa: 0.0 ± 0.0
Trp
0.61TrpAla: 0.61 ± 0.29
0.407TrpCys: 0.407 ± 0.267
1.424TrpAsp: 1.424 ± 0.597
1.017TrpGlu: 1.017 ± 0.421
0.407TrpPhe: 0.407 ± 0.255
1.424TrpGly: 1.424 ± 0.414
0.203TrpHis: 0.203 ± 0.18
0.203TrpIle: 0.203 ± 0.2
0.407TrpLys: 0.407 ± 0.272
0.407TrpLeu: 0.407 ± 0.311
0.407TrpMet: 0.407 ± 0.315
0.61TrpAsn: 0.61 ± 0.573
0.61TrpPro: 0.61 ± 0.331
0.0TrpGln: 0.0 ± 0.0
1.831TrpArg: 1.831 ± 0.56
1.221TrpSer: 1.221 ± 0.5
0.407TrpThr: 0.407 ± 0.267
1.831TrpVal: 1.831 ± 0.479
0.203TrpTrp: 0.203 ± 0.207
0.407TrpTyr: 0.407 ± 0.314
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.035TyrAla: 2.035 ± 0.663
0.0TyrCys: 0.0 ± 0.0
2.848TyrAsp: 2.848 ± 0.79
1.424TyrGlu: 1.424 ± 0.629
0.61TyrPhe: 0.61 ± 0.397
1.628TyrGly: 1.628 ± 0.513
0.203TyrHis: 0.203 ± 0.18
1.424TyrIle: 1.424 ± 0.481
0.407TyrLys: 0.407 ± 0.28
4.273TyrLeu: 4.273 ± 1.254
0.407TyrMet: 0.407 ± 0.257
0.814TyrAsn: 0.814 ± 0.334
1.424TyrPro: 1.424 ± 0.593
1.628TyrGln: 1.628 ± 0.427
2.645TyrArg: 2.645 ± 0.911
1.017TyrSer: 1.017 ± 0.486
1.424TyrThr: 1.424 ± 0.584
3.459TyrVal: 3.459 ± 0.732
0.407TyrTrp: 0.407 ± 0.276
1.424TyrTyr: 1.424 ± 0.65
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 28 proteins (4916 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski