Amino acid dipepetide frequency for Chloroherpeton thalassium (strain ATCC 35110 / GB-78)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.105AlaAla: 7.105 ± 0.12	0.801AlaCys: 0.801 ± 0.035	3.971AlaAsp: 3.971 ± 0.072	6.077AlaGlu: 6.077 ± 0.119	3.873AlaPhe: 3.873 ± 0.058	5.407AlaGly: 5.407 ± 0.097	1.571AlaHis: 1.571 ± 0.041	5.767AlaIle: 5.767 ± 0.095	5.406AlaLys: 5.406 ± 0.084	8.649AlaLeu: 8.649 ± 0.125	2.166AlaMet: 2.166 ± 0.055	2.977AlaAsn: 2.977 ± 0.054	2.576AlaPro: 2.576 ± 0.054	2.998AlaGln: 2.998 ± 0.066	3.432AlaArg: 3.432 ± 0.069	5.232AlaSer: 5.232 ± 0.086	4.241AlaThr: 4.241 ± 0.074	5.435AlaVal: 5.435 ± 0.083	0.75AlaTrp: 0.75 ± 0.032	2.709AlaTyr: 2.709 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.711CysAla: 0.711 ± 0.027	0.11CysCys: 0.11 ± 0.011	0.539CysAsp: 0.539 ± 0.025	0.578CysGlu: 0.578 ± 0.03	0.461CysPhe: 0.461 ± 0.024	0.792CysGly: 0.792 ± 0.03	0.269CysHis: 0.269 ± 0.018	0.528CysIle: 0.528 ± 0.027	0.491CysLys: 0.491 ± 0.027	0.783CysLeu: 0.783 ± 0.028	0.159CysMet: 0.159 ± 0.012	0.353CysAsn: 0.353 ± 0.022	0.426CysPro: 0.426 ± 0.022	0.319CysGln: 0.319 ± 0.018	0.388CysArg: 0.388 ± 0.021	0.576CysSer: 0.576 ± 0.027	0.454CysThr: 0.454 ± 0.022	0.577CysVal: 0.577 ± 0.028	0.088CysTrp: 0.088 ± 0.009	0.383CysTyr: 0.383 ± 0.024	0.0CysXaa: 0.0 ± 0.0
Asp	4.69AspAla: 4.69 ± 0.084	0.467AspCys: 0.467 ± 0.024	2.936AspAsp: 2.936 ± 0.073	4.34AspGlu: 4.34 ± 0.079	3.198AspPhe: 3.198 ± 0.057	3.823AspGly: 3.823 ± 0.085	0.709AspHis: 0.709 ± 0.03	3.867AspIle: 3.867 ± 0.076	3.035AspLys: 3.035 ± 0.058	4.85AspLeu: 4.85 ± 0.082	1.349AspMet: 1.349 ± 0.037	1.72AspAsn: 1.72 ± 0.054	1.766AspPro: 1.766 ± 0.047	1.112AspGln: 1.112 ± 0.037	2.06AspArg: 2.06 ± 0.045	3.329AspSer: 3.329 ± 0.068	2.407AspThr: 2.407 ± 0.054	3.699AspVal: 3.699 ± 0.071	0.672AspTrp: 0.672 ± 0.027	2.152AspTyr: 2.152 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.939GluAla: 5.939 ± 0.098	0.436GluCys: 0.436 ± 0.024	3.092GluAsp: 3.092 ± 0.071	4.89GluGlu: 4.89 ± 0.11	2.876GluPhe: 2.876 ± 0.056	3.378GluGly: 3.378 ± 0.07	1.497GluHis: 1.497 ± 0.047	5.644GluIle: 5.644 ± 0.087	6.621GluLys: 6.621 ± 0.109	7.049GluLeu: 7.049 ± 0.105	1.816GluMet: 1.816 ± 0.049	3.987GluAsn: 3.987 ± 0.074	2.378GluPro: 2.378 ± 0.057	2.87GluGln: 2.87 ± 0.064	3.596GluArg: 3.596 ± 0.072	4.248GluSer: 4.248 ± 0.069	4.167GluThr: 4.167 ± 0.073	4.442GluVal: 4.442 ± 0.074	0.631GluTrp: 0.631 ± 0.024	2.033GluTyr: 2.033 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.714PheAla: 3.714 ± 0.069	0.481PheCys: 0.481 ± 0.024	2.8PheAsp: 2.8 ± 0.049	3.424PheGlu: 3.424 ± 0.066	2.921PhePhe: 2.921 ± 0.077	3.681PheGly: 3.681 ± 0.07	1.022PheHis: 1.022 ± 0.035	3.085PheIle: 3.085 ± 0.061	2.395PheLys: 2.395 ± 0.058	4.943PheLeu: 4.943 ± 0.092	0.983PheMet: 0.983 ± 0.033	2.058PheAsn: 2.058 ± 0.055	1.856PhePro: 1.856 ± 0.05	1.707PheGln: 1.707 ± 0.053	2.136PheArg: 2.136 ± 0.053	4.435PheSer: 4.435 ± 0.083	2.304PheThr: 2.304 ± 0.047	3.189PheVal: 3.189 ± 0.065	0.59PheTrp: 0.59 ± 0.026	1.857PheTyr: 1.857 ± 0.047	0.0PheXaa: 0.0 ± 0.0
Gly	5.059GlyAla: 5.059 ± 0.1	0.723GlyCys: 0.723 ± 0.031	3.349GlyAsp: 3.349 ± 0.082	4.469GlyGlu: 4.469 ± 0.085	3.643GlyPhe: 3.643 ± 0.071	4.643GlyGly: 4.643 ± 0.093	1.314GlyHis: 1.314 ± 0.043	4.867GlyIle: 4.867 ± 0.082	5.328GlyLys: 5.328 ± 0.088	6.343GlyLeu: 6.343 ± 0.091	1.722GlyMet: 1.722 ± 0.044	2.742GlyAsn: 2.742 ± 0.069	1.146GlyPro: 1.146 ± 0.04	2.054GlyGln: 2.054 ± 0.052	2.683GlyArg: 2.683 ± 0.056	4.143GlySer: 4.143 ± 0.111	3.799GlyThr: 3.799 ± 0.094	4.682GlyVal: 4.682 ± 0.074	0.742GlyTrp: 0.742 ± 0.032	2.746GlyTyr: 2.746 ± 0.066	0.0GlyXaa: 0.0 ± 0.0
His	1.672HisAla: 1.672 ± 0.051	0.202HisCys: 0.202 ± 0.015	1.086HisAsp: 1.086 ± 0.04	1.451HisGlu: 1.451 ± 0.044	1.214HisPhe: 1.214 ± 0.035	1.326HisGly: 1.326 ± 0.042	0.669HisHis: 0.669 ± 0.031	1.345HisIle: 1.345 ± 0.036	0.981HisLys: 0.981 ± 0.036	1.986HisLeu: 1.986 ± 0.043	0.305HisMet: 0.305 ± 0.017	0.74HisAsn: 0.74 ± 0.028	1.105HisPro: 1.105 ± 0.039	0.805HisGln: 0.805 ± 0.032	1.01HisArg: 1.01 ± 0.036	1.202HisSer: 1.202 ± 0.034	0.948HisThr: 0.948 ± 0.035	1.273HisVal: 1.273 ± 0.043	0.214HisTrp: 0.214 ± 0.015	0.78HisTyr: 0.78 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.624IleAla: 5.624 ± 0.087	0.785IleCys: 0.785 ± 0.031	4.23IleAsp: 4.23 ± 0.07	5.046IleGlu: 5.046 ± 0.084	3.585IlePhe: 3.585 ± 0.076	5.049IleGly: 5.049 ± 0.106	1.385IleHis: 1.385 ± 0.042	4.149IleIle: 4.149 ± 0.079	3.612IleLys: 3.612 ± 0.074	6.492IleLeu: 6.492 ± 0.092	1.211IleMet: 1.211 ± 0.035	2.761IleAsn: 2.761 ± 0.061	2.801IlePro: 2.801 ± 0.057	2.388IleGln: 2.388 ± 0.05	3.16IleArg: 3.16 ± 0.067	5.6IleSer: 5.6 ± 0.096	3.604IleThr: 3.604 ± 0.078	4.277IleVal: 4.277 ± 0.081	0.669IleTrp: 0.669 ± 0.022	2.46IleTyr: 2.46 ± 0.06	0.0IleXaa: 0.0 ± 0.0
Lys	5.053LysAla: 5.053 ± 0.095	0.437LysCys: 0.437 ± 0.022	2.944LysAsp: 2.944 ± 0.064	4.675LysGlu: 4.675 ± 0.089	2.381LysPhe: 2.381 ± 0.047	3.444LysGly: 3.444 ± 0.057	1.383LysHis: 1.383 ± 0.043	5.047LysIle: 5.047 ± 0.069	5.233LysLys: 5.233 ± 0.106	6.138LysLeu: 6.138 ± 0.102	1.861LysMet: 1.861 ± 0.044	3.503LysAsn: 3.503 ± 0.062	2.698LysPro: 2.698 ± 0.064	2.539LysGln: 2.539 ± 0.053	3.084LysArg: 3.084 ± 0.069	4.366LysSer: 4.366 ± 0.074	3.996LysThr: 3.996 ± 0.06	4.072LysVal: 4.072 ± 0.071	0.624LysTrp: 0.624 ± 0.029	2.213LysTyr: 2.213 ± 0.059	0.0LysXaa: 0.0 ± 0.0
Leu	8.362LeuAla: 8.362 ± 0.119	0.983LeuCys: 0.983 ± 0.034	5.01LeuAsp: 5.01 ± 0.09	6.64LeuGlu: 6.64 ± 0.099	4.84LeuPhe: 4.84 ± 0.09	6.665LeuGly: 6.665 ± 0.108	1.905LeuHis: 1.905 ± 0.055	6.48LeuIle: 6.48 ± 0.11	6.826LeuLys: 6.826 ± 0.083	9.66LeuLeu: 9.66 ± 0.139	2.142LeuMet: 2.142 ± 0.051	4.364LeuAsn: 4.364 ± 0.073	4.275LeuPro: 4.275 ± 0.077	3.803LeuGln: 3.803 ± 0.074	4.632LeuArg: 4.632 ± 0.073	7.932LeuSer: 7.932 ± 0.1	5.177LeuThr: 5.177 ± 0.078	5.785LeuVal: 5.785 ± 0.087	0.859LeuTrp: 0.859 ± 0.039	2.966LeuTyr: 2.966 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	1.963MetAla: 1.963 ± 0.052	0.128MetCys: 0.128 ± 0.013	1.016MetAsp: 1.016 ± 0.039	1.291MetGlu: 1.291 ± 0.035	0.825MetPhe: 0.825 ± 0.031	1.387MetGly: 1.387 ± 0.045	0.397MetHis: 0.397 ± 0.019	1.532MetIle: 1.532 ± 0.041	1.863MetLys: 1.863 ± 0.046	2.58MetLeu: 2.58 ± 0.047	0.725MetMet: 0.725 ± 0.03	1.265MetAsn: 1.265 ± 0.039	1.209MetPro: 1.209 ± 0.034	1.027MetGln: 1.027 ± 0.037	1.144MetArg: 1.144 ± 0.036	1.538MetSer: 1.538 ± 0.037	1.276MetThr: 1.276 ± 0.039	1.447MetVal: 1.447 ± 0.041	0.139MetTrp: 0.139 ± 0.011	0.552MetTyr: 0.552 ± 0.025	0.0MetXaa: 0.0 ± 0.0
Asn	3.611AsnAla: 3.611 ± 0.068	0.421AsnCys: 0.421 ± 0.026	2.136AsnAsp: 2.136 ± 0.052	2.944AsnGlu: 2.944 ± 0.059	2.147AsnPhe: 2.147 ± 0.055	3.074AsnGly: 3.074 ± 0.075	0.852AsnHis: 0.852 ± 0.028	3.091AsnIle: 3.091 ± 0.06	2.093AsnLys: 2.093 ± 0.049	4.377AsnLeu: 4.377 ± 0.084	0.983AsnMet: 0.983 ± 0.03	1.675AsnAsn: 1.675 ± 0.057	2.388AsnPro: 2.388 ± 0.05	1.635AsnGln: 1.635 ± 0.043	2.049AsnArg: 2.049 ± 0.053	2.601AsnSer: 2.601 ± 0.074	2.129AsnThr: 2.129 ± 0.064	2.646AsnVal: 2.646 ± 0.061	0.49AsnTrp: 0.49 ± 0.028	1.72AsnTyr: 1.72 ± 0.048	0.0AsnXaa: 0.0 ± 0.0
Pro	2.831ProAla: 2.831 ± 0.062	0.327ProCys: 0.327 ± 0.02	2.569ProAsp: 2.569 ± 0.065	3.723ProGlu: 3.723 ± 0.069	1.909ProPhe: 1.909 ± 0.042	2.2ProGly: 2.2 ± 0.06	0.774ProHis: 0.774 ± 0.031	2.723ProIle: 2.723 ± 0.056	2.562ProLys: 2.562 ± 0.054	3.322ProLeu: 3.322 ± 0.06	0.807ProMet: 0.807 ± 0.032	1.961ProAsn: 1.961 ± 0.046	1.304ProPro: 1.304 ± 0.042	1.195ProGln: 1.195 ± 0.044	1.183ProArg: 1.183 ± 0.037	2.395ProSer: 2.395 ± 0.063	1.963ProThr: 1.963 ± 0.053	2.764ProVal: 2.764 ± 0.056	0.311ProTrp: 0.311 ± 0.021	1.377ProTyr: 1.377 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.196GlnAla: 3.196 ± 0.06	0.216GlnCys: 0.216 ± 0.015	1.626GlnAsp: 1.626 ± 0.048	2.465GlnGlu: 2.465 ± 0.051	1.543GlnPhe: 1.543 ± 0.044	1.882GlnGly: 1.882 ± 0.046	0.752GlnHis: 0.752 ± 0.029	2.62GlnIle: 2.62 ± 0.052	2.985GlnLys: 2.985 ± 0.067	3.352GlnLeu: 3.352 ± 0.071	0.915GlnMet: 0.915 ± 0.031	1.967GlnAsn: 1.967 ± 0.05	1.393GlnPro: 1.393 ± 0.042	1.402GlnGln: 1.402 ± 0.05	1.635GlnArg: 1.635 ± 0.048	2.344GlnSer: 2.344 ± 0.057	2.152GlnThr: 2.152 ± 0.055	2.264GlnVal: 2.264 ± 0.052	0.261GlnTrp: 0.261 ± 0.018	1.051GlnTyr: 1.051 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	3.207ArgAla: 3.207 ± 0.063	0.362ArgCys: 0.362 ± 0.02	2.199ArgAsp: 2.199 ± 0.046	3.39ArgGlu: 3.39 ± 0.068	2.49ArgPhe: 2.49 ± 0.058	2.286ArgGly: 2.286 ± 0.052	1.028ArgHis: 1.028 ± 0.039	3.127ArgIle: 3.127 ± 0.054	3.292ArgLys: 3.292 ± 0.067	4.874ArgLeu: 4.874 ± 0.077	1.127ArgMet: 1.127 ± 0.039	2.011ArgAsn: 2.011 ± 0.045	1.513ArgPro: 1.513 ± 0.044	1.731ArgGln: 1.731 ± 0.047	2.429ArgArg: 2.429 ± 0.068	2.514ArgSer: 2.514 ± 0.057	2.233ArgThr: 2.233 ± 0.047	2.959ArgVal: 2.959 ± 0.055	0.459ArgTrp: 0.459 ± 0.021	1.821ArgTyr: 1.821 ± 0.05	0.0ArgXaa: 0.0 ± 0.0
Ser	5.473SerAla: 5.473 ± 0.092	0.573SerCys: 0.573 ± 0.028	3.735SerAsp: 3.735 ± 0.065	5.028SerGlu: 5.028 ± 0.09	3.493SerPhe: 3.493 ± 0.07	5.545SerGly: 5.545 ± 0.114	1.387SerHis: 1.387 ± 0.039	4.376SerIle: 4.376 ± 0.07	3.603SerLys: 3.603 ± 0.069	7.252SerLeu: 7.252 ± 0.106	1.482SerMet: 1.482 ± 0.043	2.511SerAsn: 2.511 ± 0.077	2.759SerPro: 2.759 ± 0.056	2.407SerGln: 2.407 ± 0.053	2.839SerArg: 2.839 ± 0.061	4.732SerSer: 4.732 ± 0.13	3.312SerThr: 3.312 ± 0.088	4.628SerVal: 4.628 ± 0.086	0.672SerTrp: 0.672 ± 0.035	2.326SerTyr: 2.326 ± 0.056	0.0SerXaa: 0.0 ± 0.0
Thr	4.331ThrAla: 4.331 ± 0.075	0.475ThrCys: 0.475 ± 0.024	2.957ThrAsp: 2.957 ± 0.06	3.601ThrGlu: 3.601 ± 0.069	2.402ThrPhe: 2.402 ± 0.063	4.221ThrGly: 4.221 ± 0.077	1.135ThrHis: 1.135 ± 0.039	3.572ThrIle: 3.572 ± 0.076	2.798ThrLys: 2.798 ± 0.05	5.593ThrLeu: 5.593 ± 0.092	1.034ThrMet: 1.034 ± 0.032	2.129ThrAsn: 2.129 ± 0.059	2.354ThrPro: 2.354 ± 0.056	1.656ThrGln: 1.656 ± 0.042	2.04ThrArg: 2.04 ± 0.047	3.28ThrSer: 3.28 ± 0.078	2.876ThrThr: 2.876 ± 0.074	3.892ThrVal: 3.892 ± 0.083	0.479ThrTrp: 0.479 ± 0.024	1.898ThrTyr: 1.898 ± 0.052	0.0ThrXaa: 0.0 ± 0.0
Val	5.265ValAla: 5.265 ± 0.089	0.685ValCys: 0.685 ± 0.028	3.274ValAsp: 3.274 ± 0.069	4.29ValGlu: 4.29 ± 0.075	3.417ValPhe: 3.417 ± 0.064	4.341ValGly: 4.341 ± 0.088	1.242ValHis: 1.242 ± 0.035	4.441ValIle: 4.441 ± 0.081	3.991ValLys: 3.991 ± 0.079	6.643ValLeu: 6.643 ± 0.096	1.545ValMet: 1.545 ± 0.037	2.369ValAsn: 2.369 ± 0.059	2.532ValPro: 2.532 ± 0.053	2.344ValGln: 2.344 ± 0.048	3.196ValArg: 3.196 ± 0.058	4.834ValSer: 4.834 ± 0.083	3.428ValThr: 3.428 ± 0.071	4.599ValVal: 4.599 ± 0.086	0.646ValTrp: 0.646 ± 0.028	2.013ValTyr: 2.013 ± 0.052	0.0ValXaa: 0.0 ± 0.0
Trp	0.691TrpAla: 0.691 ± 0.028	0.093TrpCys: 0.093 ± 0.011	0.53TrpAsp: 0.53 ± 0.026	0.61TrpGlu: 0.61 ± 0.024	0.472TrpPhe: 0.472 ± 0.023	0.614TrpGly: 0.614 ± 0.025	0.261TrpHis: 0.261 ± 0.015	0.67TrpIle: 0.67 ± 0.029	0.614TrpLys: 0.614 ± 0.025	1.166TrpLeu: 1.166 ± 0.04	0.304TrpMet: 0.304 ± 0.02	0.472TrpAsn: 0.472 ± 0.024	0.309TrpPro: 0.309 ± 0.021	0.521TrpGln: 0.521 ± 0.024	0.545TrpArg: 0.545 ± 0.026	0.519TrpSer: 0.519 ± 0.025	0.473TrpThr: 0.473 ± 0.023	0.548TrpVal: 0.548 ± 0.027	0.123TrpTrp: 0.123 ± 0.014	0.301TrpTyr: 0.301 ± 0.023	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.648TyrAla: 2.648 ± 0.054	0.282TyrCys: 0.282 ± 0.02	2.184TyrAsp: 2.184 ± 0.053	2.658TyrGlu: 2.658 ± 0.062	1.891TyrPhe: 1.891 ± 0.047	2.435TyrGly: 2.435 ± 0.059	0.76TyrHis: 0.76 ± 0.027	1.958TyrIle: 1.958 ± 0.053	1.961TyrLys: 1.961 ± 0.053	3.255TyrLeu: 3.255 ± 0.055	0.667TyrMet: 0.667 ± 0.027	1.499TyrAsn: 1.499 ± 0.042	1.415TyrPro: 1.415 ± 0.042	1.506TyrGln: 1.506 ± 0.046	1.811TyrArg: 1.811 ± 0.046	2.316TyrSer: 2.316 ± 0.059	1.784TyrThr: 1.784 ± 0.047	1.913TyrVal: 1.913 ± 0.043	0.417TyrTrp: 0.417 ± 0.022	1.348TyrTyr: 1.348 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2708 proteins (947848 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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