Amino acid dipepetide frequency for Corynebacterium genitalium ATCC 33030

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	15.08AlaAla: 15.08 ± 0.193	0.838AlaCys: 0.838 ± 0.036	7.314AlaAsp: 7.314 ± 0.124	8.045AlaGlu: 8.045 ± 0.124	3.524AlaPhe: 3.524 ± 0.073	10.325AlaGly: 10.325 ± 0.135	2.285AlaHis: 2.285 ± 0.058	5.138AlaIle: 5.138 ± 0.088	3.523AlaLys: 3.523 ± 0.071	11.101AlaLeu: 11.101 ± 0.142	2.877AlaMet: 2.877 ± 0.072	2.957AlaAsn: 2.957 ± 0.073	5.397AlaPro: 5.397 ± 0.12	4.124AlaGln: 4.124 ± 0.076	6.967AlaArg: 6.967 ± 0.117	5.925AlaSer: 5.925 ± 0.104	6.534AlaThr: 6.534 ± 0.112	9.887AlaVal: 9.887 ± 0.147	1.534AlaTrp: 1.534 ± 0.054	2.37AlaTyr: 2.37 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.8CysAla: 0.8 ± 0.035	0.062CysCys: 0.062 ± 0.011	0.376CysAsp: 0.376 ± 0.023	0.386CysGlu: 0.386 ± 0.026	0.261CysPhe: 0.261 ± 0.018	0.73CysGly: 0.73 ± 0.033	0.13CysHis: 0.13 ± 0.014	0.296CysIle: 0.296 ± 0.02	0.152CysLys: 0.152 ± 0.013	0.559CysLeu: 0.559 ± 0.029	0.119CysMet: 0.119 ± 0.014	0.162CysAsn: 0.162 ± 0.013	0.352CysPro: 0.352 ± 0.026	0.172CysGln: 0.172 ± 0.018	0.36CysArg: 0.36 ± 0.026	0.455CysSer: 0.455 ± 0.027	0.388CysThr: 0.388 ± 0.024	0.551CysVal: 0.551 ± 0.033	0.081CysTrp: 0.081 ± 0.011	0.146CysTyr: 0.146 ± 0.015	0.0CysXaa: 0.0 ± 0.0
Asp	7.568AspAla: 7.568 ± 0.105	0.381AspCys: 0.381 ± 0.024	4.31AspAsp: 4.31 ± 0.084	4.911AspGlu: 4.911 ± 0.103	2.115AspPhe: 2.115 ± 0.059	5.837AspGly: 5.837 ± 0.114	1.211AspHis: 1.211 ± 0.044	3.239AspIle: 3.239 ± 0.071	2.117AspLys: 2.117 ± 0.057	5.617AspLeu: 5.617 ± 0.092	1.402AspMet: 1.402 ± 0.046	2.022AspAsn: 2.022 ± 0.061	4.056AspPro: 4.056 ± 0.089	1.825AspGln: 1.825 ± 0.056	3.659AspArg: 3.659 ± 0.078	3.319AspSer: 3.319 ± 0.068	3.646AspThr: 3.646 ± 0.075	5.099AspVal: 5.099 ± 0.085	0.848AspTrp: 0.848 ± 0.04	1.619AspTyr: 1.619 ± 0.058	0.0AspXaa: 0.0 ± 0.0
Glu	7.063GluAla: 7.063 ± 0.12	0.373GluCys: 0.373 ± 0.028	3.849GluAsp: 3.849 ± 0.077	5.043GluGlu: 5.043 ± 0.12	2.206GluPhe: 2.206 ± 0.055	4.673GluGly: 4.673 ± 0.09	1.551GluHis: 1.551 ± 0.046	3.458GluIle: 3.458 ± 0.085	2.616GluLys: 2.616 ± 0.069	7.03GluLeu: 7.03 ± 0.101	1.523GluMet: 1.523 ± 0.053	2.129GluAsn: 2.129 ± 0.064	3.485GluPro: 3.485 ± 0.126	2.833GluGln: 2.833 ± 0.062	4.443GluArg: 4.443 ± 0.08	3.388GluSer: 3.388 ± 0.068	3.737GluThr: 3.737 ± 0.091	4.861GluVal: 4.861 ± 0.087	0.919GluTrp: 0.919 ± 0.039	1.374GluTyr: 1.374 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	3.818PheAla: 3.818 ± 0.071	0.261PheCys: 0.261 ± 0.018	2.424PheAsp: 2.424 ± 0.055	1.873PheGlu: 1.873 ± 0.056	1.235PhePhe: 1.235 ± 0.046	3.395PheGly: 3.395 ± 0.074	0.663PheHis: 0.663 ± 0.031	1.698PheIle: 1.698 ± 0.053	0.841PheLys: 0.841 ± 0.035	2.865PheLeu: 2.865 ± 0.069	0.74PheMet: 0.74 ± 0.035	1.011PheAsn: 1.011 ± 0.036	1.489PhePro: 1.489 ± 0.045	0.835PheGln: 0.835 ± 0.04	1.662PheArg: 1.662 ± 0.041	2.041PheSer: 2.041 ± 0.055	2.38PheThr: 2.38 ± 0.063	2.506PheVal: 2.506 ± 0.064	0.468PheTrp: 0.468 ± 0.029	0.737PheTyr: 0.737 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.175GlyAla: 9.175 ± 0.13	0.629GlyCys: 0.629 ± 0.029	4.98GlyAsp: 4.98 ± 0.094	5.665GlyGlu: 5.665 ± 0.093	3.205GlyPhe: 3.205 ± 0.067	7.081GlyGly: 7.081 ± 0.128	1.832GlyHis: 1.832 ± 0.054	4.705GlyIle: 4.705 ± 0.083	3.034GlyLys: 3.034 ± 0.077	7.734GlyLeu: 7.734 ± 0.116	2.383GlyMet: 2.383 ± 0.062	2.351GlyAsn: 2.351 ± 0.054	3.625GlyPro: 3.625 ± 0.072	2.872GlyGln: 2.872 ± 0.076	4.979GlyArg: 4.979 ± 0.085	5.014GlySer: 5.014 ± 0.078	5.326GlyThr: 5.326 ± 0.09	6.9GlyVal: 6.9 ± 0.107	1.377GlyTrp: 1.377 ± 0.048	2.263GlyTyr: 2.263 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.175HisAla: 2.175 ± 0.054	0.149HisCys: 0.149 ± 0.015	1.401HisAsp: 1.401 ± 0.04	1.309HisGlu: 1.309 ± 0.044	0.6HisPhe: 0.6 ± 0.033	1.783HisGly: 1.783 ± 0.049	0.499HisHis: 0.499 ± 0.029	0.974HisIle: 0.974 ± 0.037	0.481HisLys: 0.481 ± 0.023	1.874HisLeu: 1.874 ± 0.059	0.432HisMet: 0.432 ± 0.023	0.598HisAsn: 0.598 ± 0.027	1.473HisPro: 1.473 ± 0.044	0.646HisGln: 0.646 ± 0.03	1.324HisArg: 1.324 ± 0.043	1.089HisSer: 1.089 ± 0.037	1.228HisThr: 1.228 ± 0.04	1.628HisVal: 1.628 ± 0.06	0.262HisTrp: 0.262 ± 0.02	0.5HisTyr: 0.5 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	6.442IleAla: 6.442 ± 0.105	0.396IleCys: 0.396 ± 0.028	3.951IleAsp: 3.951 ± 0.076	3.232IleGlu: 3.232 ± 0.072	1.565IlePhe: 1.565 ± 0.053	4.466IleGly: 4.466 ± 0.087	0.95IleHis: 0.95 ± 0.037	2.47IleIle: 2.47 ± 0.068	1.275IleLys: 1.275 ± 0.044	3.849IleLeu: 3.849 ± 0.087	1.134IleMet: 1.134 ± 0.045	1.48IleAsn: 1.48 ± 0.043	2.677IlePro: 2.677 ± 0.062	1.311IleGln: 1.311 ± 0.047	2.647IleArg: 2.647 ± 0.055	2.817IleSer: 2.817 ± 0.057	3.18IleThr: 3.18 ± 0.063	4.24IleVal: 4.24 ± 0.077	0.476IleTrp: 0.476 ± 0.026	1.06IleTyr: 1.06 ± 0.037	0.0IleXaa: 0.0 ± 0.0
Lys	3.279LysAla: 3.279 ± 0.082	0.123LysCys: 0.123 ± 0.013	1.996LysAsp: 1.996 ± 0.057	2.054LysGlu: 2.054 ± 0.054	0.785LysPhe: 0.785 ± 0.031	2.248LysGly: 2.248 ± 0.074	0.716LysHis: 0.716 ± 0.032	1.474LysIle: 1.474 ± 0.05	1.611LysLys: 1.611 ± 0.064	2.987LysLeu: 2.987 ± 0.064	0.712LysMet: 0.712 ± 0.034	1.113LysAsn: 1.113 ± 0.041	1.796LysPro: 1.796 ± 0.067	1.198LysGln: 1.198 ± 0.045	2.186LysArg: 2.186 ± 0.059	1.542LysSer: 1.542 ± 0.046	1.86LysThr: 1.86 ± 0.059	2.348LysVal: 2.348 ± 0.068	0.407LysTrp: 0.407 ± 0.026	0.699LysTyr: 0.699 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	11.388LeuAla: 11.388 ± 0.143	0.583LeuCys: 0.583 ± 0.029	6.202LeuAsp: 6.202 ± 0.105	5.376LeuGlu: 5.376 ± 0.088	2.954LeuPhe: 2.954 ± 0.085	7.987LeuGly: 7.987 ± 0.12	1.741LeuHis: 1.741 ± 0.053	5.053LeuIle: 5.053 ± 0.094	2.505LeuLys: 2.505 ± 0.074	8.285LeuLeu: 8.285 ± 0.136	1.91LeuMet: 1.91 ± 0.056	2.61LeuAsn: 2.61 ± 0.061	4.992LeuPro: 4.992 ± 0.085	2.458LeuGln: 2.458 ± 0.055	5.909LeuArg: 5.909 ± 0.1	5.545LeuSer: 5.545 ± 0.11	5.876LeuThr: 5.876 ± 0.101	7.708LeuVal: 7.708 ± 0.125	1.086LeuTrp: 1.086 ± 0.043	1.774LeuTyr: 1.774 ± 0.048	0.0LeuXaa: 0.0 ± 0.0
Met	2.705MetAla: 2.705 ± 0.068	0.167MetCys: 0.167 ± 0.016	1.307MetAsp: 1.307 ± 0.042	1.205MetGlu: 1.205 ± 0.043	0.75MetPhe: 0.75 ± 0.035	1.844MetGly: 1.844 ± 0.053	0.466MetHis: 0.466 ± 0.025	1.236MetIle: 1.236 ± 0.048	0.746MetLys: 0.746 ± 0.03	2.247MetLeu: 2.247 ± 0.064	0.568MetMet: 0.568 ± 0.031	0.825MetAsn: 0.825 ± 0.03	1.303MetPro: 1.303 ± 0.044	0.71MetGln: 0.71 ± 0.034	1.473MetArg: 1.473 ± 0.044	1.722MetSer: 1.722 ± 0.052	1.822MetThr: 1.822 ± 0.049	1.748MetVal: 1.748 ± 0.059	0.329MetTrp: 0.329 ± 0.028	0.407MetTyr: 0.407 ± 0.024	0.0MetXaa: 0.0 ± 0.0
Asn	3.194AsnAla: 3.194 ± 0.071	0.177AsnCys: 0.177 ± 0.015	1.759AsnAsp: 1.759 ± 0.049	1.809AsnGlu: 1.809 ± 0.058	0.91AsnPhe: 0.91 ± 0.043	2.477AsnGly: 2.477 ± 0.084	0.628AsnHis: 0.628 ± 0.03	1.374AsnIle: 1.374 ± 0.042	0.889AsnLys: 0.889 ± 0.041	2.594AsnLeu: 2.594 ± 0.061	0.702AsnMet: 0.702 ± 0.036	0.98AsnAsn: 0.98 ± 0.044	2.168AsnPro: 2.168 ± 0.06	1.043AsnGln: 1.043 ± 0.042	1.74AsnArg: 1.74 ± 0.047	1.615AsnSer: 1.615 ± 0.056	1.697AsnThr: 1.697 ± 0.051	2.307AsnVal: 2.307 ± 0.054	0.437AsnTrp: 0.437 ± 0.025	0.751AsnTyr: 0.751 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	6.096ProAla: 6.096 ± 0.118	0.242ProCys: 0.242 ± 0.02	3.76ProAsp: 3.76 ± 0.084	4.827ProGlu: 4.827 ± 0.103	1.725ProPhe: 1.725 ± 0.049	4.803ProGly: 4.803 ± 0.095	1.157ProHis: 1.157 ± 0.045	2.022ProIle: 2.022 ± 0.051	1.571ProLys: 1.571 ± 0.054	4.399ProLeu: 4.399 ± 0.086	1.116ProMet: 1.116 ± 0.041	1.51ProAsn: 1.51 ± 0.045	2.091ProPro: 2.091 ± 0.069	1.87ProGln: 1.87 ± 0.05	2.779ProArg: 2.779 ± 0.062	2.915ProSer: 2.915 ± 0.068	3.147ProThr: 3.147 ± 0.09	4.619ProVal: 4.619 ± 0.086	0.773ProTrp: 0.773 ± 0.033	1.13ProTyr: 1.13 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	3.727GlnAla: 3.727 ± 0.092	0.174GlnCys: 0.174 ± 0.014	1.68GlnAsp: 1.68 ± 0.064	1.982GlnGlu: 1.982 ± 0.058	1.033GlnPhe: 1.033 ± 0.038	2.326GlnGly: 2.326 ± 0.062	0.618GlnHis: 0.618 ± 0.029	1.724GlnIle: 1.724 ± 0.051	1.026GlnLys: 1.026 ± 0.042	3.414GlnLeu: 3.414 ± 0.07	0.852GlnMet: 0.852 ± 0.031	0.897GlnAsn: 0.897 ± 0.036	2.015GlnPro: 2.015 ± 0.077	1.533GlnGln: 1.533 ± 0.069	2.504GlnArg: 2.504 ± 0.071	1.595GlnSer: 1.595 ± 0.054	1.605GlnThr: 1.605 ± 0.052	2.368GlnVal: 2.368 ± 0.058	0.55GlnTrp: 0.55 ± 0.03	0.717GlnTyr: 0.717 ± 0.034	0.0GlnXaa: 0.0 ± 0.0
Arg	6.618ArgAla: 6.618 ± 0.123	0.344ArgCys: 0.344 ± 0.023	4.069ArgAsp: 4.069 ± 0.084	4.551ArgGlu: 4.551 ± 0.092	2.125ArgPhe: 2.125 ± 0.059	4.626ArgGly: 4.626 ± 0.098	1.287ArgHis: 1.287 ± 0.05	3.11ArgIle: 3.11 ± 0.08	2.101ArgLys: 2.101 ± 0.065	5.177ArgLeu: 5.177 ± 0.089	1.701ArgMet: 1.701 ± 0.045	1.822ArgAsn: 1.822 ± 0.058	2.835ArgPro: 2.835 ± 0.055	2.007ArgGln: 2.007 ± 0.055	4.776ArgArg: 4.776 ± 0.116	3.361ArgSer: 3.361 ± 0.082	3.76ArgThr: 3.76 ± 0.078	4.654ArgVal: 4.654 ± 0.086	0.879ArgTrp: 0.879 ± 0.035	1.628ArgTyr: 1.628 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	6.395SerAla: 6.395 ± 0.113	0.325SerCys: 0.325 ± 0.022	3.4SerAsp: 3.4 ± 0.071	3.387SerGlu: 3.387 ± 0.076	1.895SerPhe: 1.895 ± 0.05	5.502SerGly: 5.502 ± 0.1	1.096SerHis: 1.096 ± 0.037	2.638SerIle: 2.638 ± 0.072	1.68SerLys: 1.68 ± 0.053	5.038SerLeu: 5.038 ± 0.09	1.415SerMet: 1.415 ± 0.05	1.593SerAsn: 1.593 ± 0.048	2.915SerPro: 2.915 ± 0.063	1.748SerGln: 1.748 ± 0.055	3.462SerArg: 3.462 ± 0.072	3.557SerSer: 3.557 ± 0.085	3.75SerThr: 3.75 ± 0.084	4.409SerVal: 4.409 ± 0.074	0.818SerTrp: 0.818 ± 0.035	1.307SerTyr: 1.307 ± 0.04	0.0SerXaa: 0.0 ± 0.0
Thr	6.815ThrAla: 6.815 ± 0.099	0.434ThrCys: 0.434 ± 0.026	3.76ThrAsp: 3.76 ± 0.09	3.635ThrGlu: 3.635 ± 0.083	2.026ThrPhe: 2.026 ± 0.057	5.6ThrGly: 5.6 ± 0.09	1.287ThrHis: 1.287 ± 0.046	2.98ThrIle: 2.98 ± 0.064	1.69ThrLys: 1.69 ± 0.055	5.781ThrLeu: 5.781 ± 0.102	1.331ThrMet: 1.331 ± 0.045	1.646ThrAsn: 1.646 ± 0.046	3.801ThrPro: 3.801 ± 0.083	1.765ThrGln: 1.765 ± 0.047	3.445ThrArg: 3.445 ± 0.072	3.581ThrSer: 3.581 ± 0.079	4.082ThrThr: 4.082 ± 0.156	5.591ThrVal: 5.591 ± 0.121	0.926ThrTrp: 0.926 ± 0.041	1.44ThrTyr: 1.44 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.637ValAla: 9.637 ± 0.135	0.598ValCys: 0.598 ± 0.028	5.959ValAsp: 5.959 ± 0.098	5.187ValGlu: 5.187 ± 0.092	2.613ValPhe: 2.613 ± 0.069	6.357ValGly: 6.357 ± 0.102	1.588ValHis: 1.588 ± 0.051	4.293ValIle: 4.293 ± 0.073	2.301ValLys: 2.301 ± 0.066	7.725ValLeu: 7.725 ± 0.112	1.796ValMet: 1.796 ± 0.049	2.325ValAsn: 2.325 ± 0.061	4.167ValPro: 4.167 ± 0.085	2.114ValGln: 2.114 ± 0.058	4.674ValArg: 4.674 ± 0.084	4.663ValSer: 4.663 ± 0.083	5.526ValThr: 5.526 ± 0.097	7.517ValVal: 7.517 ± 0.145	1.11ValTrp: 1.11 ± 0.043	1.62ValTyr: 1.62 ± 0.041	0.0ValXaa: 0.0 ± 0.0
Trp	1.472TrpAla: 1.472 ± 0.049	0.111TrpCys: 0.111 ± 0.013	0.751TrpAsp: 0.751 ± 0.033	0.746TrpGlu: 0.746 ± 0.029	0.544TrpPhe: 0.544 ± 0.029	0.999TrpGly: 0.999 ± 0.044	0.295TrpHis: 0.295 ± 0.02	0.754TrpIle: 0.754 ± 0.033	0.413TrpLys: 0.413 ± 0.025	1.533TrpLeu: 1.533 ± 0.052	0.42TrpMet: 0.42 ± 0.025	0.451TrpAsn: 0.451 ± 0.025	0.682TrpPro: 0.682 ± 0.032	0.51TrpGln: 0.51 ± 0.031	0.927TrpArg: 0.927 ± 0.035	0.798TrpSer: 0.798 ± 0.04	0.78TrpThr: 0.78 ± 0.033	1.161TrpVal: 1.161 ± 0.043	0.333TrpTrp: 0.333 ± 0.023	0.258TrpTyr: 0.258 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.298TyrAla: 2.298 ± 0.052	0.169TyrCys: 0.169 ± 0.016	1.552TyrAsp: 1.552 ± 0.049	1.33TyrGlu: 1.33 ± 0.046	0.869TyrPhe: 0.869 ± 0.036	2.07TyrGly: 2.07 ± 0.065	0.425TyrHis: 0.425 ± 0.027	0.981TyrIle: 0.981 ± 0.034	0.567TyrLys: 0.567 ± 0.032	2.132TyrLeu: 2.132 ± 0.066	0.448TyrMet: 0.448 ± 0.027	0.768TyrAsn: 0.768 ± 0.034	1.235TyrPro: 1.235 ± 0.049	0.766TyrGln: 0.766 ± 0.034	1.518TyrArg: 1.518 ± 0.049	1.388TyrSer: 1.388 ± 0.045	1.292TyrThr: 1.292 ± 0.046	1.667TyrVal: 1.667 ± 0.052	0.326TyrTrp: 0.326 ± 0.02	0.561TyrTyr: 0.561 ± 0.03	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2216 proteins (705372 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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