Amino acid dipepetide frequency for Acidaminobacter hydrogenoformans DSM 2784

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	8.961AlaAla: 8.961 ± 0.14	0.869AlaCys: 0.869 ± 0.033	4.09AlaAsp: 4.09 ± 0.079	5.642AlaGlu: 5.642 ± 0.08	3.952AlaPhe: 3.952 ± 0.079	6.724AlaGly: 6.724 ± 0.085	1.542AlaHis: 1.542 ± 0.039	5.976AlaIle: 5.976 ± 0.086	4.329AlaLys: 4.329 ± 0.065	10.139AlaLeu: 10.139 ± 0.125	2.843AlaMet: 2.843 ± 0.064	2.443AlaAsn: 2.443 ± 0.047	2.753AlaPro: 2.753 ± 0.061	2.587AlaGln: 2.587 ± 0.054	3.513AlaArg: 3.513 ± 0.062	4.928AlaSer: 4.928 ± 0.079	3.755AlaThr: 3.755 ± 0.072	7.018AlaVal: 7.018 ± 0.081	0.715AlaTrp: 0.715 ± 0.029	2.916AlaTyr: 2.916 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.716CysAla: 0.716 ± 0.028	0.123CysCys: 0.123 ± 0.012	0.536CysAsp: 0.536 ± 0.024	0.58CysGlu: 0.58 ± 0.023	0.365CysPhe: 0.365 ± 0.019	1.125CysGly: 1.125 ± 0.04	0.253CysHis: 0.253 ± 0.017	0.577CysIle: 0.577 ± 0.023	0.437CysLys: 0.437 ± 0.021	0.807CysLeu: 0.807 ± 0.025	0.211CysMet: 0.211 ± 0.014	0.31CysAsn: 0.31 ± 0.018	0.494CysPro: 0.494 ± 0.027	0.27CysGln: 0.27 ± 0.016	0.481CysArg: 0.481 ± 0.024	0.633CysSer: 0.633 ± 0.024	0.49CysThr: 0.49 ± 0.024	0.656CysVal: 0.656 ± 0.027	0.083CysTrp: 0.083 ± 0.008	0.298CysTyr: 0.298 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	4.353AspAla: 4.353 ± 0.073	0.508AspCys: 0.508 ± 0.023	2.382AspAsp: 2.382 ± 0.082	3.756AspGlu: 3.756 ± 0.081	2.573AspPhe: 2.573 ± 0.054	3.808AspGly: 3.808 ± 0.069	1.217AspHis: 1.217 ± 0.035	3.512AspIle: 3.512 ± 0.062	2.789AspLys: 2.789 ± 0.062	5.904AspLeu: 5.904 ± 0.085	1.514AspMet: 1.514 ± 0.037	1.659AspAsn: 1.659 ± 0.043	2.422AspPro: 2.422 ± 0.068	2.056AspGln: 2.056 ± 0.041	2.814AspArg: 2.814 ± 0.054	2.59AspSer: 2.59 ± 0.057	2.458AspThr: 2.458 ± 0.056	3.756AspVal: 3.756 ± 0.06	0.529AspTrp: 0.529 ± 0.023	2.274AspTyr: 2.274 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	7.873GluAla: 7.873 ± 0.117	0.436GluCys: 0.436 ± 0.023	4.119GluAsp: 4.119 ± 0.074	5.354GluGlu: 5.354 ± 0.101	2.277GluPhe: 2.277 ± 0.045	4.765GluGly: 4.765 ± 0.076	1.223GluHis: 1.223 ± 0.036	5.857GluIle: 5.857 ± 0.087	4.987GluLys: 4.987 ± 0.086	6.475GluLeu: 6.475 ± 0.088	2.375GluMet: 2.375 ± 0.046	3.159GluAsn: 3.159 ± 0.063	2.276GluPro: 2.276 ± 0.061	2.019GluGln: 2.019 ± 0.049	3.721GluArg: 3.721 ± 0.065	3.56GluSer: 3.56 ± 0.067	4.095GluThr: 4.095 ± 0.07	5.481GluVal: 5.481 ± 0.071	0.518GluTrp: 0.518 ± 0.022	1.878GluTyr: 1.878 ± 0.045	0.0GluXaa: 0.0 ± 0.0
Phe	3.1PheAla: 3.1 ± 0.06	0.415PheCys: 0.415 ± 0.023	2.667PheAsp: 2.667 ± 0.057	3.408PheGlu: 3.408 ± 0.06	1.824PhePhe: 1.824 ± 0.052	3.581PheGly: 3.581 ± 0.067	0.663PheHis: 0.663 ± 0.025	2.793PheIle: 2.793 ± 0.061	2.345PheLys: 2.345 ± 0.046	3.693PheLeu: 3.693 ± 0.073	1.277PheMet: 1.277 ± 0.038	1.782PheAsn: 1.782 ± 0.043	1.345PhePro: 1.345 ± 0.038	1.069PheGln: 1.069 ± 0.033	1.747PheArg: 1.747 ± 0.048	3.044PheSer: 3.044 ± 0.065	2.217PheThr: 2.217 ± 0.047	3.054PheVal: 3.054 ± 0.06	0.376PheTrp: 0.376 ± 0.021	1.398PheTyr: 1.398 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	6.252GlyAla: 6.252 ± 0.095	0.924GlyCys: 0.924 ± 0.033	3.648GlyAsp: 3.648 ± 0.064	4.602GlyGlu: 4.602 ± 0.065	3.528GlyPhe: 3.528 ± 0.06	5.691GlyGly: 5.691 ± 0.102	1.527GlyHis: 1.527 ± 0.037	6.326GlyIle: 6.326 ± 0.084	4.532GlyLys: 4.532 ± 0.067	7.69GlyLeu: 7.69 ± 0.1	2.467GlyMet: 2.467 ± 0.056	2.484GlyAsn: 2.484 ± 0.05	2.08GlyPro: 2.08 ± 0.051	2.222GlyGln: 2.222 ± 0.045	3.506GlyArg: 3.506 ± 0.058	4.379GlySer: 4.379 ± 0.064	4.403GlyThr: 4.403 ± 0.065	5.84GlyVal: 5.84 ± 0.095	0.733GlyTrp: 0.733 ± 0.03	3.069GlyTyr: 3.069 ± 0.064	0.0GlyXaa: 0.0 ± 0.0
His	1.397HisAla: 1.397 ± 0.04	0.231HisCys: 0.231 ± 0.013	0.992HisAsp: 0.992 ± 0.036	1.296HisGlu: 1.296 ± 0.041	0.897HisPhe: 0.897 ± 0.027	1.419HisGly: 1.419 ± 0.038	0.53HisHis: 0.53 ± 0.023	1.131HisIle: 1.131 ± 0.034	0.982HisLys: 0.982 ± 0.033	1.993HisLeu: 1.993 ± 0.046	0.498HisMet: 0.498 ± 0.021	0.677HisAsn: 0.677 ± 0.025	1.04HisPro: 1.04 ± 0.031	0.679HisGln: 0.679 ± 0.028	0.924HisArg: 0.924 ± 0.029	1.081HisSer: 1.081 ± 0.033	0.902HisThr: 0.902 ± 0.033	1.218HisVal: 1.218 ± 0.035	0.215HisTrp: 0.215 ± 0.016	0.783HisTyr: 0.783 ± 0.028	0.0HisXaa: 0.0 ± 0.0
Ile	5.979IleAla: 5.979 ± 0.077	0.702IleCys: 0.702 ± 0.023	4.225IleAsp: 4.225 ± 0.074	5.697IleGlu: 5.697 ± 0.08	2.834IlePhe: 2.834 ± 0.064	5.565IleGly: 5.565 ± 0.1	1.417IleHis: 1.417 ± 0.038	4.656IleIle: 4.656 ± 0.08	3.93IleLys: 3.93 ± 0.062	7.186IleLeu: 7.186 ± 0.11	1.93IleMet: 1.93 ± 0.045	2.586IleAsn: 2.586 ± 0.057	3.091IlePro: 3.091 ± 0.06	2.405IleGln: 2.405 ± 0.055	3.567IleArg: 3.567 ± 0.074	4.732IleSer: 4.732 ± 0.074	3.699IleThr: 3.699 ± 0.068	4.959IleVal: 4.959 ± 0.073	0.479IleTrp: 0.479 ± 0.024	2.086IleTyr: 2.086 ± 0.053	0.0IleXaa: 0.0 ± 0.0
Lys	5.616LysAla: 5.616 ± 0.075	0.447LysCys: 0.447 ± 0.025	3.111LysAsp: 3.111 ± 0.053	4.065LysGlu: 4.065 ± 0.059	1.859LysPhe: 1.859 ± 0.043	3.969LysGly: 3.969 ± 0.066	1.006LysHis: 1.006 ± 0.03	4.174LysIle: 4.174 ± 0.069	4.005LysLys: 4.005 ± 0.076	5.575LysLeu: 5.575 ± 0.079	1.792LysMet: 1.792 ± 0.04	2.456LysAsn: 2.456 ± 0.048	2.225LysPro: 2.225 ± 0.051	1.616LysGln: 1.616 ± 0.038	3.116LysArg: 3.116 ± 0.06	3.429LysSer: 3.429 ± 0.061	3.343LysThr: 3.343 ± 0.054	4.28LysVal: 4.28 ± 0.074	0.501LysTrp: 0.501 ± 0.023	1.915LysTyr: 1.915 ± 0.048	0.0LysXaa: 0.0 ± 0.0
Leu	7.748LeuAla: 7.748 ± 0.099	0.885LeuCys: 0.885 ± 0.03	5.394LeuAsp: 5.394 ± 0.076	8.041LeuGlu: 8.041 ± 0.109	4.054LeuPhe: 4.054 ± 0.079	7.425LeuGly: 7.425 ± 0.101	1.611LeuHis: 1.611 ± 0.041	7.406LeuIle: 7.406 ± 0.105	6.862LeuLys: 6.862 ± 0.076	9.523LeuLeu: 9.523 ± 0.118	3.509LeuMet: 3.509 ± 0.061	4.065LeuAsn: 4.065 ± 0.068	3.994LeuPro: 3.994 ± 0.071	2.66LeuGln: 2.66 ± 0.05	4.651LeuArg: 4.651 ± 0.071	7.355LeuSer: 7.355 ± 0.086	5.648LeuThr: 5.648 ± 0.072	6.569LeuVal: 6.569 ± 0.089	0.783LeuTrp: 0.783 ± 0.028	3.094LeuTyr: 3.094 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	2.804MetAla: 2.804 ± 0.061	0.19MetCys: 0.19 ± 0.015	1.701MetAsp: 1.701 ± 0.04	1.864MetGlu: 1.864 ± 0.041	0.95MetPhe: 0.95 ± 0.03	2.253MetGly: 2.253 ± 0.055	0.437MetHis: 0.437 ± 0.021	2.295MetIle: 2.295 ± 0.054	2.205MetLys: 2.205 ± 0.046	2.926MetLeu: 2.926 ± 0.064	1.003MetMet: 1.003 ± 0.036	1.364MetAsn: 1.364 ± 0.032	1.339MetPro: 1.339 ± 0.035	0.748MetGln: 0.748 ± 0.028	1.349MetArg: 1.349 ± 0.041	1.965MetSer: 1.965 ± 0.04	2.179MetThr: 2.179 ± 0.046	2.148MetVal: 2.148 ± 0.049	0.15MetTrp: 0.15 ± 0.012	0.636MetTyr: 0.636 ± 0.027	0.0MetXaa: 0.0 ± 0.0
Asn	3.065AsnAla: 3.065 ± 0.054	0.427AsnCys: 0.427 ± 0.022	1.728AsnAsp: 1.728 ± 0.047	2.437AsnGlu: 2.437 ± 0.047	1.484AsnPhe: 1.484 ± 0.039	2.774AsnGly: 2.774 ± 0.053	0.763AsnHis: 0.763 ± 0.029	2.579AsnIle: 2.579 ± 0.056	2.042AsnLys: 2.042 ± 0.055	3.86AsnLeu: 3.86 ± 0.059	1.004AsnMet: 1.004 ± 0.032	1.351AsnAsn: 1.351 ± 0.043	1.985AsnPro: 1.985 ± 0.049	1.317AsnGln: 1.317 ± 0.036	1.881AsnArg: 1.881 ± 0.044	1.832AsnSer: 1.832 ± 0.051	1.884AsnThr: 1.884 ± 0.045	2.656AsnVal: 2.656 ± 0.051	0.344AsnTrp: 0.344 ± 0.02	1.267AsnTyr: 1.267 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	3.272ProAla: 3.272 ± 0.075	0.335ProCys: 0.335 ± 0.018	2.233ProAsp: 2.233 ± 0.05	4.046ProGlu: 4.046 ± 0.073	1.687ProPhe: 1.687 ± 0.043	3.092ProGly: 3.092 ± 0.063	0.718ProHis: 0.718 ± 0.025	2.381ProIle: 2.381 ± 0.054	1.875ProLys: 1.875 ± 0.041	3.632ProLeu: 3.632 ± 0.068	1.044ProMet: 1.044 ± 0.035	1.235ProAsn: 1.235 ± 0.032	1.113ProPro: 1.113 ± 0.037	1.141ProGln: 1.141 ± 0.037	1.291ProArg: 1.291 ± 0.032	2.209ProSer: 2.209 ± 0.045	1.846ProThr: 1.846 ± 0.045	3.457ProVal: 3.457 ± 0.06	0.351ProTrp: 0.351 ± 0.019	1.353ProTyr: 1.353 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	2.562GlnAla: 2.562 ± 0.055	0.264GlnCys: 0.264 ± 0.018	1.457GlnAsp: 1.457 ± 0.039	1.932GlnGlu: 1.932 ± 0.043	1.118GlnPhe: 1.118 ± 0.035	2.075GlnGly: 2.075 ± 0.048	0.545GlnHis: 0.545 ± 0.022	2.279GlnIle: 2.279 ± 0.049	1.96GlnLys: 1.96 ± 0.039	3.131GlnLeu: 3.131 ± 0.058	0.942GlnMet: 0.942 ± 0.03	1.275GlnAsn: 1.275 ± 0.041	1.158GlnPro: 1.158 ± 0.035	0.933GlnGln: 0.933 ± 0.031	1.553GlnArg: 1.553 ± 0.042	1.843GlnSer: 1.843 ± 0.038	1.642GlnThr: 1.642 ± 0.038	2.157GlnVal: 2.157 ± 0.041	0.304GlnTrp: 0.304 ± 0.018	1.015GlnTyr: 1.015 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	3.421ArgAla: 3.421 ± 0.062	0.426ArgCys: 0.426 ± 0.022	2.504ArgAsp: 2.504 ± 0.051	3.526ArgGlu: 3.526 ± 0.061	2.168ArgPhe: 2.168 ± 0.05	3.015ArgGly: 3.015 ± 0.05	1.083ArgHis: 1.083 ± 0.032	3.648ArgIle: 3.648 ± 0.065	2.722ArgLys: 2.722 ± 0.056	4.982ArgLeu: 4.982 ± 0.084	1.535ArgMet: 1.535 ± 0.041	1.694ArgAsn: 1.694 ± 0.042	1.668ArgPro: 1.668 ± 0.038	1.726ArgGln: 1.726 ± 0.049	2.683ArgArg: 2.683 ± 0.056	2.559ArgSer: 2.559 ± 0.054	2.269ArgThr: 2.269 ± 0.051	3.307ArgVal: 3.307 ± 0.062	0.445ArgTrp: 0.445 ± 0.025	1.807ArgTyr: 1.807 ± 0.04	0.0ArgXaa: 0.0 ± 0.0
Ser	4.914SerAla: 4.914 ± 0.074	0.58SerCys: 0.58 ± 0.027	3.01SerAsp: 3.01 ± 0.06	4.474SerGlu: 4.474 ± 0.072	2.667SerPhe: 2.667 ± 0.05	5.382SerGly: 5.382 ± 0.075	1.151SerHis: 1.151 ± 0.036	4.177SerIle: 4.177 ± 0.066	3.39SerLys: 3.39 ± 0.054	6.067SerLeu: 6.067 ± 0.082	1.748SerMet: 1.748 ± 0.046	2.096SerAsn: 2.096 ± 0.047	2.23SerPro: 2.23 ± 0.048	1.813SerGln: 1.813 ± 0.041	2.798SerArg: 2.798 ± 0.057	3.57SerSer: 3.57 ± 0.074	3.065SerThr: 3.065 ± 0.065	4.514SerVal: 4.514 ± 0.068	0.508SerTrp: 0.508 ± 0.021	1.877SerTyr: 1.877 ± 0.045	0.0SerXaa: 0.0 ± 0.0
Thr	4.691ThrAla: 4.691 ± 0.071	0.489ThrCys: 0.489 ± 0.025	2.538ThrAsp: 2.538 ± 0.058	3.34ThrGlu: 3.34 ± 0.061	2.272ThrPhe: 2.272 ± 0.05	4.895ThrGly: 4.895 ± 0.077	1.065ThrHis: 1.065 ± 0.034	3.732ThrIle: 3.732 ± 0.07	2.46ThrLys: 2.46 ± 0.045	5.831ThrLeu: 5.831 ± 0.078	1.374ThrMet: 1.374 ± 0.034	1.744ThrAsn: 1.744 ± 0.04	2.57ThrPro: 2.57 ± 0.053	1.497ThrGln: 1.497 ± 0.04	2.183ThrArg: 2.183 ± 0.042	3.068ThrSer: 3.068 ± 0.064	2.873ThrThr: 2.873 ± 0.065	4.162ThrVal: 4.162 ± 0.064	0.469ThrTrp: 0.469 ± 0.024	1.717ThrTyr: 1.717 ± 0.038	0.0ThrXaa: 0.0 ± 0.0
Val	5.883ValAla: 5.883 ± 0.095	0.693ValCys: 0.693 ± 0.028	4.035ValAsp: 4.035 ± 0.062	5.395ValGlu: 5.395 ± 0.083	3.228ValPhe: 3.228 ± 0.058	5.004ValGly: 5.004 ± 0.091	1.269ValHis: 1.269 ± 0.036	5.429ValIle: 5.429 ± 0.073	4.364ValLys: 4.364 ± 0.067	7.57ValLeu: 7.57 ± 0.094	2.361ValMet: 2.361 ± 0.051	2.675ValAsn: 2.675 ± 0.05	2.903ValPro: 2.903 ± 0.051	1.951ValGln: 1.951 ± 0.046	3.333ValArg: 3.333 ± 0.065	4.836ValSer: 4.836 ± 0.066	4.073ValThr: 4.073 ± 0.07	5.892ValVal: 5.892 ± 0.085	0.563ValTrp: 0.563 ± 0.025	2.377ValTyr: 2.377 ± 0.053	0.0ValXaa: 0.0 ± 0.0
Trp	0.6TrpAla: 0.6 ± 0.024	0.09TrpCys: 0.09 ± 0.01	0.406TrpAsp: 0.406 ± 0.018	0.476TrpGlu: 0.476 ± 0.021	0.398TrpPhe: 0.398 ± 0.021	0.632TrpGly: 0.632 ± 0.026	0.187TrpHis: 0.187 ± 0.014	0.706TrpIle: 0.706 ± 0.026	0.439TrpLys: 0.439 ± 0.019	1.004TrpLeu: 1.004 ± 0.036	0.279TrpMet: 0.279 ± 0.015	0.338TrpAsn: 0.338 ± 0.017	0.32TrpPro: 0.32 ± 0.018	0.304TrpGln: 0.304 ± 0.017	0.411TrpArg: 0.411 ± 0.02	0.495TrpSer: 0.495 ± 0.026	0.459TrpThr: 0.459 ± 0.022	0.533TrpVal: 0.533 ± 0.026	0.089TrpTrp: 0.089 ± 0.01	0.274TrpTyr: 0.274 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.491TyrAla: 2.491 ± 0.052	0.41TyrCys: 0.41 ± 0.02	2.097TyrAsp: 2.097 ± 0.046	2.519TyrGlu: 2.519 ± 0.058	1.664TyrPhe: 1.664 ± 0.041	2.707TyrGly: 2.707 ± 0.055	0.676TyrHis: 0.676 ± 0.028	2.09TyrIle: 2.09 ± 0.051	1.844TyrLys: 1.844 ± 0.048	3.288TyrLeu: 3.288 ± 0.066	0.803TyrMet: 0.803 ± 0.032	1.289TyrAsn: 1.289 ± 0.034	1.306TyrPro: 1.306 ± 0.034	1.131TyrGln: 1.131 ± 0.032	1.663TyrArg: 1.663 ± 0.046	1.921TyrSer: 1.921 ± 0.044	1.669TyrThr: 1.669 ± 0.041	2.178TyrVal: 2.178 ± 0.051	0.285TyrTrp: 0.285 ± 0.018	1.313TyrTyr: 1.313 ± 0.039	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3277 proteins (1050301 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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