Amino acid dipepetide frequency for Corynebacterium glaucum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.318AlaAla: 16.318 ± 0.242	0.86AlaCys: 0.86 ± 0.036	7.182AlaAsp: 7.182 ± 0.119	8.341AlaGlu: 8.341 ± 0.117	3.8AlaPhe: 3.8 ± 0.096	10.294AlaGly: 10.294 ± 0.126	2.336AlaHis: 2.336 ± 0.056	5.553AlaIle: 5.553 ± 0.1	3.691AlaLys: 3.691 ± 0.073	11.744AlaLeu: 11.744 ± 0.173	2.794AlaMet: 2.794 ± 0.059	3.143AlaAsn: 3.143 ± 0.066	5.9AlaPro: 5.9 ± 0.13	4.412AlaGln: 4.412 ± 0.097	7.074AlaArg: 7.074 ± 0.123	6.281AlaSer: 6.281 ± 0.112	7.186AlaThr: 7.186 ± 0.116	9.896AlaVal: 9.896 ± 0.158	1.628AlaTrp: 1.628 ± 0.05	2.48AlaTyr: 2.48 ± 0.061	0.0AlaXaa: 0.0 ± 0.0
Cys	0.765CysAla: 0.765 ± 0.031	0.072CysCys: 0.072 ± 0.011	0.368CysAsp: 0.368 ± 0.025	0.386CysGlu: 0.386 ± 0.026	0.208CysPhe: 0.208 ± 0.019	0.648CysGly: 0.648 ± 0.034	0.15CysHis: 0.15 ± 0.015	0.268CysIle: 0.268 ± 0.018	0.131CysLys: 0.131 ± 0.013	0.482CysLeu: 0.482 ± 0.029	0.124CysMet: 0.124 ± 0.013	0.177CysAsn: 0.177 ± 0.014	0.346CysPro: 0.346 ± 0.024	0.192CysGln: 0.192 ± 0.017	0.343CysArg: 0.343 ± 0.025	0.373CysSer: 0.373 ± 0.02	0.401CysThr: 0.401 ± 0.02	0.506CysVal: 0.506 ± 0.026	0.085CysTrp: 0.085 ± 0.01	0.131CysTyr: 0.131 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.928AspAla: 7.928 ± 0.124	0.347AspCys: 0.347 ± 0.021	3.808AspAsp: 3.808 ± 0.099	4.778AspGlu: 4.778 ± 0.1	2.12AspPhe: 2.12 ± 0.058	5.556AspGly: 5.556 ± 0.116	1.134AspHis: 1.134 ± 0.042	2.851AspIle: 2.851 ± 0.066	1.806AspLys: 1.806 ± 0.052	5.41AspLeu: 5.41 ± 0.104	1.258AspMet: 1.258 ± 0.039	1.743AspAsn: 1.743 ± 0.052	3.801AspPro: 3.801 ± 0.08	1.858AspGln: 1.858 ± 0.053	3.547AspArg: 3.547 ± 0.072	3.014AspSer: 3.014 ± 0.069	3.501AspThr: 3.501 ± 0.067	4.789AspVal: 4.789 ± 0.088	0.831AspTrp: 0.831 ± 0.033	1.53AspTyr: 1.53 ± 0.051	0.0AspXaa: 0.0 ± 0.0
Glu	7.866GluAla: 7.866 ± 0.125	0.355GluCys: 0.355 ± 0.022	3.664GluAsp: 3.664 ± 0.075	4.485GluGlu: 4.485 ± 0.087	2.322GluPhe: 2.322 ± 0.064	4.655GluGly: 4.655 ± 0.078	1.644GluHis: 1.644 ± 0.046	3.522GluIle: 3.522 ± 0.075	2.064GluLys: 2.064 ± 0.056	7.301GluLeu: 7.301 ± 0.122	1.443GluMet: 1.443 ± 0.055	1.878GluAsn: 1.878 ± 0.053	3.327GluPro: 3.327 ± 0.085	2.793GluGln: 2.793 ± 0.067	4.729GluArg: 4.729 ± 0.084	3.198GluSer: 3.198 ± 0.076	3.774GluThr: 3.774 ± 0.074	5.41GluVal: 5.41 ± 0.092	0.957GluTrp: 0.957 ± 0.04	1.452GluTyr: 1.452 ± 0.047	0.0GluXaa: 0.0 ± 0.0
Phe	4.113PheAla: 4.113 ± 0.082	0.241PheCys: 0.241 ± 0.017	2.589PheAsp: 2.589 ± 0.061	2.111PheGlu: 2.111 ± 0.057	1.237PhePhe: 1.237 ± 0.046	3.371PheGly: 3.371 ± 0.068	0.64PheHis: 0.64 ± 0.028	1.614PheIle: 1.614 ± 0.052	0.791PheLys: 0.791 ± 0.035	2.864PheLeu: 2.864 ± 0.076	0.707PheMet: 0.707 ± 0.031	1.113PheAsn: 1.113 ± 0.04	1.454PhePro: 1.454 ± 0.046	0.877PheGln: 0.877 ± 0.034	1.615PheArg: 1.615 ± 0.042	1.944PheSer: 1.944 ± 0.052	2.279PheThr: 2.279 ± 0.062	2.6PheVal: 2.6 ± 0.061	0.476PheTrp: 0.476 ± 0.028	0.824PheTyr: 0.824 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	8.995GlyAla: 8.995 ± 0.128	0.609GlyCys: 0.609 ± 0.03	4.765GlyAsp: 4.765 ± 0.089	5.784GlyGlu: 5.784 ± 0.091	3.086GlyPhe: 3.086 ± 0.073	6.954GlyGly: 6.954 ± 0.139	1.722GlyHis: 1.722 ± 0.043	4.516GlyIle: 4.516 ± 0.08	2.943GlyLys: 2.943 ± 0.07	7.773GlyLeu: 7.773 ± 0.11	2.183GlyMet: 2.183 ± 0.055	2.295GlyAsn: 2.295 ± 0.058	3.454GlyPro: 3.454 ± 0.072	2.893GlyGln: 2.893 ± 0.065	4.707GlyArg: 4.707 ± 0.084	4.842GlySer: 4.842 ± 0.093	5.289GlyThr: 5.289 ± 0.081	7.149GlyVal: 7.149 ± 0.097	1.359GlyTrp: 1.359 ± 0.041	2.238GlyTyr: 2.238 ± 0.057	0.0GlyXaa: 0.0 ± 0.0
His	2.198HisAla: 2.198 ± 0.056	0.154HisCys: 0.154 ± 0.015	1.253HisAsp: 1.253 ± 0.042	1.238HisGlu: 1.238 ± 0.037	0.649HisPhe: 0.649 ± 0.025	1.819HisGly: 1.819 ± 0.054	0.536HisHis: 0.536 ± 0.029	0.941HisIle: 0.941 ± 0.035	0.44HisLys: 0.44 ± 0.025	1.972HisLeu: 1.972 ± 0.055	0.434HisMet: 0.434 ± 0.021	0.603HisAsn: 0.603 ± 0.027	1.46HisPro: 1.46 ± 0.048	0.67HisGln: 0.67 ± 0.028	1.309HisArg: 1.309 ± 0.041	1.107HisSer: 1.107 ± 0.037	1.2HisThr: 1.2 ± 0.044	1.585HisVal: 1.585 ± 0.051	0.284HisTrp: 0.284 ± 0.021	0.494HisTyr: 0.494 ± 0.031	0.0HisXaa: 0.0 ± 0.0
Ile	6.777IleAla: 6.777 ± 0.106	0.34IleCys: 0.34 ± 0.02	3.854IleAsp: 3.854 ± 0.068	3.387IleGlu: 3.387 ± 0.084	1.552IlePhe: 1.552 ± 0.055	4.389IleGly: 4.389 ± 0.087	0.856IleHis: 0.856 ± 0.035	2.322IleIle: 2.322 ± 0.072	1.15IleLys: 1.15 ± 0.046	3.776IleLeu: 3.776 ± 0.081	1.0IleMet: 1.0 ± 0.042	1.414IleAsn: 1.414 ± 0.045	2.479IlePro: 2.479 ± 0.06	1.312IleGln: 1.312 ± 0.044	2.566IleArg: 2.566 ± 0.06	2.666IleSer: 2.666 ± 0.056	3.185IleThr: 3.185 ± 0.066	4.163IleVal: 4.163 ± 0.076	0.551IleTrp: 0.551 ± 0.032	1.016IleTyr: 1.016 ± 0.04	0.0IleXaa: 0.0 ± 0.0
Lys	3.286LysAla: 3.286 ± 0.078	0.12LysCys: 0.12 ± 0.014	1.71LysAsp: 1.71 ± 0.05	1.836LysGlu: 1.836 ± 0.049	0.852LysPhe: 0.852 ± 0.036	2.106LysGly: 2.106 ± 0.051	0.699LysHis: 0.699 ± 0.031	1.325LysIle: 1.325 ± 0.046	1.31LysLys: 1.31 ± 0.06	2.847LysLeu: 2.847 ± 0.053	0.701LysMet: 0.701 ± 0.029	0.942LysAsn: 0.942 ± 0.043	1.664LysPro: 1.664 ± 0.045	1.262LysGln: 1.262 ± 0.043	2.259LysArg: 2.259 ± 0.06	1.472LysSer: 1.472 ± 0.045	1.74LysThr: 1.74 ± 0.053	2.278LysVal: 2.278 ± 0.063	0.411LysTrp: 0.411 ± 0.023	0.645LysTyr: 0.645 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	12.126LeuAla: 12.126 ± 0.156	0.542LeuCys: 0.542 ± 0.027	6.093LeuAsp: 6.093 ± 0.097	5.565LeuGlu: 5.565 ± 0.102	2.794LeuPhe: 2.794 ± 0.073	8.015LeuGly: 8.015 ± 0.113	1.763LeuHis: 1.763 ± 0.046	5.03LeuIle: 5.03 ± 0.094	2.475LeuLys: 2.475 ± 0.057	8.756LeuLeu: 8.756 ± 0.143	1.895LeuMet: 1.895 ± 0.052	2.595LeuAsn: 2.595 ± 0.067	5.085LeuPro: 5.085 ± 0.094	2.622LeuGln: 2.622 ± 0.059	6.16LeuArg: 6.16 ± 0.105	5.409LeuSer: 5.409 ± 0.087	6.097LeuThr: 6.097 ± 0.093	7.751LeuVal: 7.751 ± 0.13	1.019LeuTrp: 1.019 ± 0.04	1.848LeuTyr: 1.848 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	2.623MetAla: 2.623 ± 0.06	0.121MetCys: 0.121 ± 0.013	1.147MetAsp: 1.147 ± 0.039	1.154MetGlu: 1.154 ± 0.041	0.731MetPhe: 0.731 ± 0.034	1.709MetGly: 1.709 ± 0.047	0.493MetHis: 0.493 ± 0.024	1.191MetIle: 1.191 ± 0.04	0.658MetLys: 0.658 ± 0.029	2.237MetLeu: 2.237 ± 0.064	0.53MetMet: 0.53 ± 0.025	0.69MetAsn: 0.69 ± 0.031	1.292MetPro: 1.292 ± 0.041	0.752MetGln: 0.752 ± 0.033	1.567MetArg: 1.567 ± 0.043	1.58MetSer: 1.58 ± 0.047	1.628MetThr: 1.628 ± 0.045	1.742MetVal: 1.742 ± 0.053	0.309MetTrp: 0.309 ± 0.02	0.414MetTyr: 0.414 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.323AsnAla: 3.323 ± 0.067	0.156AsnCys: 0.156 ± 0.015	1.512AsnAsp: 1.512 ± 0.047	1.728AsnGlu: 1.728 ± 0.058	0.977AsnPhe: 0.977 ± 0.038	2.329AsnGly: 2.329 ± 0.063	0.606AsnHis: 0.606 ± 0.025	1.253AsnIle: 1.253 ± 0.041	0.815AsnLys: 0.815 ± 0.039	2.696AsnLeu: 2.696 ± 0.059	0.595AsnMet: 0.595 ± 0.029	0.845AsnAsn: 0.845 ± 0.036	2.223AsnPro: 2.223 ± 0.06	1.045AsnGln: 1.045 ± 0.039	1.744AsnArg: 1.744 ± 0.051	1.592AsnSer: 1.592 ± 0.049	1.65AsnThr: 1.65 ± 0.051	2.229AsnVal: 2.229 ± 0.059	0.423AsnTrp: 0.423 ± 0.024	0.77AsnTyr: 0.77 ± 0.034	0.0AsnXaa: 0.0 ± 0.0
Pro	6.297ProAla: 6.297 ± 0.129	0.185ProCys: 0.185 ± 0.02	3.515ProAsp: 3.515 ± 0.072	4.536ProGlu: 4.536 ± 0.085	1.756ProPhe: 1.756 ± 0.054	4.633ProGly: 4.633 ± 0.08	1.099ProHis: 1.099 ± 0.042	2.141ProIle: 2.141 ± 0.061	1.665ProLys: 1.665 ± 0.051	4.322ProLeu: 4.322 ± 0.084	1.074ProMet: 1.074 ± 0.039	1.656ProAsn: 1.656 ± 0.047	2.089ProPro: 2.089 ± 0.068	1.895ProGln: 1.895 ± 0.049	2.731ProArg: 2.731 ± 0.073	2.923ProSer: 2.923 ± 0.068	3.239ProThr: 3.239 ± 0.073	4.524ProVal: 4.524 ± 0.077	0.716ProTrp: 0.716 ± 0.033	1.171ProTyr: 1.171 ± 0.042	0.0ProXaa: 0.0 ± 0.0
Gln	3.905GlnAla: 3.905 ± 0.07	0.171GlnCys: 0.171 ± 0.016	1.586GlnAsp: 1.586 ± 0.049	2.019GlnGlu: 2.019 ± 0.056	1.187GlnPhe: 1.187 ± 0.049	2.347GlnGly: 2.347 ± 0.057	0.732GlnHis: 0.732 ± 0.029	1.715GlnIle: 1.715 ± 0.051	0.932GlnLys: 0.932 ± 0.041	3.735GlnLeu: 3.735 ± 0.072	0.903GlnMet: 0.903 ± 0.034	0.936GlnAsn: 0.936 ± 0.034	1.912GlnPro: 1.912 ± 0.068	1.526GlnGln: 1.526 ± 0.061	2.61GlnArg: 2.61 ± 0.067	1.614GlnSer: 1.614 ± 0.046	1.759GlnThr: 1.759 ± 0.042	2.756GlnVal: 2.756 ± 0.062	0.502GlnTrp: 0.502 ± 0.031	0.707GlnTyr: 0.707 ± 0.031	0.0GlnXaa: 0.0 ± 0.0
Arg	6.829ArgAla: 6.829 ± 0.126	0.308ArgCys: 0.308 ± 0.023	3.961ArgAsp: 3.961 ± 0.078	4.663ArgGlu: 4.663 ± 0.084	2.184ArgPhe: 2.184 ± 0.056	4.725ArgGly: 4.725 ± 0.094	1.245ArgHis: 1.245 ± 0.035	3.16ArgIle: 3.16 ± 0.071	2.036ArgLys: 2.036 ± 0.056	5.397ArgLeu: 5.397 ± 0.097	1.761ArgMet: 1.761 ± 0.052	1.753ArgAsn: 1.753 ± 0.054	2.865ArgPro: 2.865 ± 0.072	2.102ArgGln: 2.102 ± 0.058	4.729ArgArg: 4.729 ± 0.118	3.329ArgSer: 3.329 ± 0.068	3.582ArgThr: 3.582 ± 0.072	4.98ArgVal: 4.98 ± 0.083	0.938ArgTrp: 0.938 ± 0.039	1.589ArgTyr: 1.589 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	6.239SerAla: 6.239 ± 0.088	0.309SerCys: 0.309 ± 0.02	3.11SerAsp: 3.11 ± 0.067	3.419SerGlu: 3.419 ± 0.071	1.811SerPhe: 1.811 ± 0.051	5.198SerGly: 5.198 ± 0.076	1.104SerHis: 1.104 ± 0.044	2.492SerIle: 2.492 ± 0.06	1.72SerLys: 1.72 ± 0.053	4.967SerLeu: 4.967 ± 0.083	1.352SerMet: 1.352 ± 0.049	1.652SerAsn: 1.652 ± 0.046	2.842SerPro: 2.842 ± 0.066	1.874SerGln: 1.874 ± 0.056	3.466SerArg: 3.466 ± 0.071	3.555SerSer: 3.555 ± 0.076	3.697SerThr: 3.697 ± 0.072	4.216SerVal: 4.216 ± 0.079	0.808SerTrp: 0.808 ± 0.034	1.299SerTyr: 1.299 ± 0.041	0.0SerXaa: 0.0 ± 0.0
Thr	7.062ThrAla: 7.062 ± 0.118	0.39ThrCys: 0.39 ± 0.021	3.659ThrAsp: 3.659 ± 0.068	3.71ThrGlu: 3.71 ± 0.081	1.985ThrPhe: 1.985 ± 0.059	5.473ThrGly: 5.473 ± 0.082	1.324ThrHis: 1.324 ± 0.043	2.917ThrIle: 2.917 ± 0.071	1.723ThrLys: 1.723 ± 0.05	5.624ThrLeu: 5.624 ± 0.096	1.247ThrMet: 1.247 ± 0.036	1.622ThrAsn: 1.622 ± 0.047	3.837ThrPro: 3.837 ± 0.084	1.894ThrGln: 1.894 ± 0.058	3.558ThrArg: 3.558 ± 0.081	3.494ThrSer: 3.494 ± 0.077	4.218ThrThr: 4.218 ± 0.15	5.817ThrVal: 5.817 ± 0.089	0.935ThrTrp: 0.935 ± 0.037	1.468ThrTyr: 1.468 ± 0.047	0.0ThrXaa: 0.0 ± 0.0
Val	10.372ValAla: 10.372 ± 0.143	0.609ValCys: 0.609 ± 0.033	5.611ValAsp: 5.611 ± 0.098	5.511ValGlu: 5.511 ± 0.102	2.717ValPhe: 2.717 ± 0.066	6.3ValGly: 6.3 ± 0.098	1.548ValHis: 1.548 ± 0.049	4.274ValIle: 4.274 ± 0.078	2.196ValLys: 2.196 ± 0.056	7.905ValLeu: 7.905 ± 0.121	1.747ValMet: 1.747 ± 0.049	2.288ValAsn: 2.288 ± 0.062	4.228ValPro: 4.228 ± 0.087	2.244ValGln: 2.244 ± 0.054	4.95ValArg: 4.95 ± 0.093	4.598ValSer: 4.598 ± 0.082	5.483ValThr: 5.483 ± 0.105	7.443ValVal: 7.443 ± 0.121	1.012ValTrp: 1.012 ± 0.04	1.686ValTyr: 1.686 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	1.483TrpAla: 1.483 ± 0.045	0.101TrpCys: 0.101 ± 0.012	0.753TrpAsp: 0.753 ± 0.033	0.794TrpGlu: 0.794 ± 0.03	0.569TrpPhe: 0.569 ± 0.033	0.936TrpGly: 0.936 ± 0.04	0.287TrpHis: 0.287 ± 0.019	0.729TrpIle: 0.729 ± 0.033	0.385TrpLys: 0.385 ± 0.025	1.573TrpLeu: 1.573 ± 0.056	0.392TrpMet: 0.392 ± 0.024	0.434TrpAsn: 0.434 ± 0.027	0.69TrpPro: 0.69 ± 0.031	0.544TrpGln: 0.544 ± 0.03	0.924TrpArg: 0.924 ± 0.034	0.768TrpSer: 0.768 ± 0.034	0.749TrpThr: 0.749 ± 0.027	1.199TrpVal: 1.199 ± 0.044	0.315TrpTrp: 0.315 ± 0.024	0.273TrpTyr: 0.273 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.407TyrAla: 2.407 ± 0.051	0.17TyrCys: 0.17 ± 0.015	1.471TyrAsp: 1.471 ± 0.049	1.395TyrGlu: 1.395 ± 0.045	0.923TyrPhe: 0.923 ± 0.034	2.099TyrGly: 2.099 ± 0.057	0.431TyrHis: 0.431 ± 0.023	0.938TyrIle: 0.938 ± 0.037	0.532TyrLys: 0.532 ± 0.029	2.259TyrLeu: 2.259 ± 0.057	0.426TyrMet: 0.426 ± 0.028	0.729TyrAsn: 0.729 ± 0.033	1.22TyrPro: 1.22 ± 0.039	0.789TyrGln: 0.789 ± 0.034	1.548TyrArg: 1.548 ± 0.052	1.375TyrSer: 1.375 ± 0.047	1.3TyrThr: 1.3 ± 0.049	1.689TyrVal: 1.689 ± 0.052	0.338TyrTrp: 0.338 ± 0.024	0.581TyrTyr: 0.581 ± 0.033	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2366 proteins (760833 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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