Amino acid dipepetide frequency for Pseudosporangium ferrugineum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	24.516AlaAla: 24.516 ± 0.16	0.961AlaCys: 0.961 ± 0.023	8.707AlaAsp: 8.707 ± 0.063	8.373AlaGlu: 8.373 ± 0.075	3.446AlaPhe: 3.446 ± 0.042	15.969AlaGly: 15.969 ± 0.095	2.488AlaHis: 2.488 ± 0.033	4.014AlaIle: 4.014 ± 0.045	2.424AlaLys: 2.424 ± 0.044	14.272AlaLeu: 14.272 ± 0.095	2.642AlaMet: 2.642 ± 0.038	2.141AlaAsn: 2.141 ± 0.039	7.409AlaPro: 7.409 ± 0.074	3.518AlaGln: 3.518 ± 0.044	10.755AlaArg: 10.755 ± 0.074	5.711AlaSer: 5.711 ± 0.053	8.129AlaThr: 8.129 ± 0.066	13.038AlaVal: 13.038 ± 0.086	1.949AlaTrp: 1.949 ± 0.032	3.056AlaTyr: 3.056 ± 0.035	0.0AlaXaa: 0.0 ± 0.0
Cys	0.928CysAla: 0.928 ± 0.019	0.085CysCys: 0.085 ± 0.007	0.454CysAsp: 0.454 ± 0.016	0.312CysGlu: 0.312 ± 0.01	0.198CysPhe: 0.198 ± 0.009	0.848CysGly: 0.848 ± 0.019	0.17CysHis: 0.17 ± 0.007	0.148CysIle: 0.148 ± 0.009	0.097CysLys: 0.097 ± 0.007	0.665CysLeu: 0.665 ± 0.017	0.097CysMet: 0.097 ± 0.006	0.135CysAsn: 0.135 ± 0.008	0.475CysPro: 0.475 ± 0.015	0.138CysGln: 0.138 ± 0.007	0.589CysArg: 0.589 ± 0.016	0.36CysSer: 0.36 ± 0.014	0.457CysThr: 0.457 ± 0.013	0.564CysVal: 0.564 ± 0.016	0.105CysTrp: 0.105 ± 0.007	0.136CysTyr: 0.136 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.704AspAla: 7.704 ± 0.054	0.382AspCys: 0.382 ± 0.012	3.942AspAsp: 3.942 ± 0.048	3.723AspGlu: 3.723 ± 0.044	1.527AspPhe: 1.527 ± 0.024	6.367AspGly: 6.367 ± 0.058	1.251AspHis: 1.251 ± 0.023	1.656AspIle: 1.656 ± 0.028	0.976AspLys: 0.976 ± 0.023	6.75AspLeu: 6.75 ± 0.062	0.726AspMet: 0.726 ± 0.016	1.015AspAsn: 1.015 ± 0.023	4.812AspPro: 4.812 ± 0.047	1.504AspGln: 1.504 ± 0.028	5.478AspArg: 5.478 ± 0.052	2.249AspSer: 2.249 ± 0.031	2.854AspThr: 2.854 ± 0.039	5.021AspVal: 5.021 ± 0.046	0.926AspTrp: 0.926 ± 0.019	1.133AspTyr: 1.133 ± 0.023	0.0AspXaa: 0.0 ± 0.0
Glu	6.814GluAla: 6.814 ± 0.066	0.3GluCys: 0.3 ± 0.011	2.347GluAsp: 2.347 ± 0.027	2.621GluGlu: 2.621 ± 0.035	1.409GluPhe: 1.409 ± 0.026	3.353GluGly: 3.353 ± 0.038	1.321GluHis: 1.321 ± 0.025	2.184GluIle: 2.184 ± 0.028	1.129GluLys: 1.129 ± 0.026	6.261GluLeu: 6.261 ± 0.054	0.863GluMet: 0.863 ± 0.02	0.931GluAsn: 0.931 ± 0.02	3.456GluPro: 3.456 ± 0.039	2.065GluGln: 2.065 ± 0.031	4.898GluArg: 4.898 ± 0.05	2.224GluSer: 2.224 ± 0.03	2.61GluThr: 2.61 ± 0.031	4.393GluVal: 4.393 ± 0.047	0.694GluTrp: 0.694 ± 0.017	1.008GluTyr: 1.008 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.895PheAla: 3.895 ± 0.045	0.236PheCys: 0.236 ± 0.01	1.975PheAsp: 1.975 ± 0.028	1.246PheGlu: 1.246 ± 0.026	0.838PhePhe: 0.838 ± 0.02	2.947PheGly: 2.947 ± 0.04	0.593PheHis: 0.593 ± 0.016	0.685PheIle: 0.685 ± 0.016	0.433PheLys: 0.433 ± 0.013	2.556PheLeu: 2.556 ± 0.039	0.354PheMet: 0.354 ± 0.012	0.539PheAsn: 0.539 ± 0.016	1.376PhePro: 1.376 ± 0.025	0.629PheGln: 0.629 ± 0.015	1.898PheArg: 1.898 ± 0.029	1.395PheSer: 1.395 ± 0.024	1.931PheThr: 1.931 ± 0.03	2.318PheVal: 2.318 ± 0.031	0.421PheTrp: 0.421 ± 0.013	0.613PheTyr: 0.613 ± 0.016	0.0PheXaa: 0.0 ± 0.0
Gly	11.511GlyAla: 11.511 ± 0.067	0.739GlyCys: 0.739 ± 0.018	5.758GlyAsp: 5.758 ± 0.053	4.786GlyGlu: 4.786 ± 0.05	2.888GlyPhe: 2.888 ± 0.038	9.078GlyGly: 9.078 ± 0.09	2.109GlyHis: 2.109 ± 0.028	3.388GlyIle: 3.388 ± 0.04	2.086GlyLys: 2.086 ± 0.034	9.584GlyLeu: 9.584 ± 0.069	1.859GlyMet: 1.859 ± 0.031	1.845GlyAsn: 1.845 ± 0.037	5.397GlyPro: 5.397 ± 0.061	2.466GlyGln: 2.466 ± 0.037	8.224GlyArg: 8.224 ± 0.063	5.193GlySer: 5.193 ± 0.052	6.372GlyThr: 6.372 ± 0.06	7.948GlyVal: 7.948 ± 0.06	1.808GlyTrp: 1.808 ± 0.031	2.398GlyTyr: 2.398 ± 0.034	0.0GlyXaa: 0.0 ± 0.0
His	2.596HisAla: 2.596 ± 0.038	0.17HisCys: 0.17 ± 0.008	1.348HisAsp: 1.348 ± 0.022	1.118HisGlu: 1.118 ± 0.022	0.561HisPhe: 0.561 ± 0.014	2.096HisGly: 2.096 ± 0.03	0.632HisHis: 0.632 ± 0.018	0.549HisIle: 0.549 ± 0.014	0.268HisLys: 0.268 ± 0.012	2.348HisLeu: 2.348 ± 0.03	0.274HisMet: 0.274 ± 0.01	0.354HisAsn: 0.354 ± 0.011	1.645HisPro: 1.645 ± 0.027	0.568HisGln: 0.568 ± 0.015	2.086HisArg: 2.086 ± 0.032	0.872HisSer: 0.872 ± 0.021	1.053HisThr: 1.053 ± 0.021	1.654HisVal: 1.654 ± 0.027	0.296HisTrp: 0.296 ± 0.011	0.432HisTyr: 0.432 ± 0.014	0.0HisXaa: 0.0 ± 0.0
Ile	5.159IleAla: 5.159 ± 0.051	0.279IleCys: 0.279 ± 0.011	2.45IleAsp: 2.45 ± 0.034	1.897IleGlu: 1.897 ± 0.034	0.84IlePhe: 0.84 ± 0.02	3.61IleGly: 3.61 ± 0.044	0.544IleHis: 0.544 ± 0.014	0.986IleIle: 0.986 ± 0.023	0.653IleLys: 0.653 ± 0.016	2.584IleLeu: 2.584 ± 0.037	0.458IleMet: 0.458 ± 0.014	0.754IleAsn: 0.754 ± 0.018	1.714IlePro: 1.714 ± 0.026	0.695IleGln: 0.695 ± 0.016	2.418IleArg: 2.418 ± 0.03	1.744IleSer: 1.744 ± 0.028	2.248IleThr: 2.248 ± 0.035	3.118IleVal: 3.118 ± 0.037	0.402IleTrp: 0.402 ± 0.013	0.573IleTyr: 0.573 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	2.337LysAla: 2.337 ± 0.046	0.117LysCys: 0.117 ± 0.008	0.922LysAsp: 0.922 ± 0.021	0.796LysGlu: 0.796 ± 0.02	0.432LysPhe: 0.432 ± 0.015	1.378LysGly: 1.378 ± 0.027	0.369LysHis: 0.369 ± 0.011	0.814LysIle: 0.814 ± 0.019	0.586LysLys: 0.586 ± 0.022	1.909LysLeu: 1.909 ± 0.032	0.312LysMet: 0.312 ± 0.012	0.398LysAsn: 0.398 ± 0.013	1.241LysPro: 1.241 ± 0.029	0.569LysGln: 0.569 ± 0.017	1.334LysArg: 1.334 ± 0.025	0.88LysSer: 0.88 ± 0.023	1.039LysThr: 1.039 ± 0.027	1.671LysVal: 1.671 ± 0.03	0.243LysTrp: 0.243 ± 0.011	0.37LysTyr: 0.37 ± 0.012	0.0LysXaa: 0.0 ± 0.0
Leu	15.825LeuAla: 15.825 ± 0.108	0.719LeuCys: 0.719 ± 0.017	6.704LeuAsp: 6.704 ± 0.069	4.22LeuGlu: 4.22 ± 0.045	2.595LeuPhe: 2.595 ± 0.037	9.449LeuGly: 9.449 ± 0.063	2.293LeuHis: 2.293 ± 0.032	3.642LeuIle: 3.642 ± 0.041	1.57LeuLys: 1.57 ± 0.028	11.323LeuLeu: 11.323 ± 0.092	1.523LeuMet: 1.523 ± 0.024	1.687LeuAsn: 1.687 ± 0.029	6.491LeuPro: 6.491 ± 0.061	2.043LeuGln: 2.043 ± 0.03	9.291LeuArg: 9.291 ± 0.067	5.265LeuSer: 5.265 ± 0.05	7.01LeuThr: 7.01 ± 0.063	9.012LeuVal: 9.012 ± 0.076	1.252LeuTrp: 1.252 ± 0.025	1.692LeuTyr: 1.692 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.183MetAla: 2.183 ± 0.031	0.107MetCys: 0.107 ± 0.006	0.773MetAsp: 0.773 ± 0.018	0.59MetGlu: 0.59 ± 0.015	0.455MetPhe: 0.455 ± 0.013	1.111MetGly: 1.111 ± 0.024	0.327MetHis: 0.327 ± 0.011	0.732MetIle: 0.732 ± 0.018	0.33MetLys: 0.33 ± 0.011	1.791MetLeu: 1.791 ± 0.029	0.294MetMet: 0.294 ± 0.011	0.387MetAsn: 0.387 ± 0.013	1.152MetPro: 1.152 ± 0.022	0.431MetGln: 0.431 ± 0.014	1.425MetArg: 1.425 ± 0.023	1.232MetSer: 1.232 ± 0.023	1.574MetThr: 1.574 ± 0.027	1.308MetVal: 1.308 ± 0.024	0.211MetTrp: 0.211 ± 0.009	0.294MetTyr: 0.294 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	2.282AsnAla: 2.282 ± 0.035	0.148AsnCys: 0.148 ± 0.007	0.993AsnAsp: 0.993 ± 0.024	0.765AsnGlu: 0.765 ± 0.019	0.5AsnPhe: 0.5 ± 0.015	1.931AsnGly: 1.931 ± 0.037	0.365AsnHis: 0.365 ± 0.013	0.568AsnIle: 0.568 ± 0.014	0.33AsnLys: 0.33 ± 0.012	1.869AsnLeu: 1.869 ± 0.03	0.269AsnMet: 0.269 ± 0.011	0.474AsnAsn: 0.474 ± 0.018	1.421AsnPro: 1.421 ± 0.024	0.508AsnGln: 0.508 ± 0.015	1.426AsnArg: 1.426 ± 0.025	0.844AsnSer: 0.844 ± 0.022	1.025AsnThr: 1.025 ± 0.021	1.409AsnVal: 1.409 ± 0.022	0.311AsnTrp: 0.311 ± 0.013	0.401AsnTyr: 0.401 ± 0.015	0.0AsnXaa: 0.0 ± 0.0
Pro	10.589ProAla: 10.589 ± 0.091	0.294ProCys: 0.294 ± 0.013	4.425ProAsp: 4.425 ± 0.048	3.89ProGlu: 3.89 ± 0.043	1.47ProPhe: 1.47 ± 0.025	7.288ProGly: 7.288 ± 0.068	1.202ProHis: 1.202 ± 0.024	1.631ProIle: 1.631 ± 0.027	0.93ProLys: 0.93 ± 0.025	5.13ProLeu: 5.13 ± 0.047	1.004ProMet: 1.004 ± 0.02	0.884ProAsn: 0.884 ± 0.019	4.357ProPro: 4.357 ± 0.075	1.585ProGln: 1.585 ± 0.03	4.147ProArg: 4.147 ± 0.043	3.242ProSer: 3.242 ± 0.048	3.138ProThr: 3.138 ± 0.04	5.719ProVal: 5.719 ± 0.057	0.891ProTrp: 0.891 ± 0.022	1.288ProTyr: 1.288 ± 0.024	0.0ProXaa: 0.0 ± 0.0
Gln	3.581GlnAla: 3.581 ± 0.046	0.15GlnCys: 0.15 ± 0.008	1.135GlnAsp: 1.135 ± 0.023	1.144GlnGlu: 1.144 ± 0.025	0.738GlnPhe: 0.738 ± 0.018	1.837GlnGly: 1.837 ± 0.031	0.58GlnHis: 0.58 ± 0.015	1.092GlnIle: 1.092 ± 0.019	0.495GlnLys: 0.495 ± 0.017	2.971GlnLeu: 2.971 ± 0.037	0.438GlnMet: 0.438 ± 0.013	0.52GlnAsn: 0.52 ± 0.015	1.737GlnPro: 1.737 ± 0.033	1.101GlnGln: 1.101 ± 0.027	2.491GlnArg: 2.491 ± 0.034	1.164GlnSer: 1.164 ± 0.024	1.293GlnThr: 1.293 ± 0.024	2.377GlnVal: 2.377 ± 0.036	0.455GlnTrp: 0.455 ± 0.014	0.555GlnTyr: 0.555 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	10.441ArgAla: 10.441 ± 0.076	0.541ArgCys: 0.541 ± 0.017	4.76ArgAsp: 4.76 ± 0.045	4.419ArgGlu: 4.419 ± 0.049	2.385ArgPhe: 2.385 ± 0.034	5.952ArgGly: 5.952 ± 0.052	2.113ArgHis: 2.113 ± 0.031	3.376ArgIle: 3.376 ± 0.037	1.469ArgLys: 1.469 ± 0.032	9.328ArgLeu: 9.328 ± 0.084	1.842ArgMet: 1.842 ± 0.03	1.483ArgAsn: 1.483 ± 0.029	5.49ArgPro: 5.49 ± 0.059	2.406ArgGln: 2.406 ± 0.037	8.686ArgArg: 8.686 ± 0.097	4.121ArgSer: 4.121 ± 0.045	5.356ArgThr: 5.356 ± 0.046	6.202ArgVal: 6.202 ± 0.054	1.557ArgTrp: 1.557 ± 0.026	1.954ArgTyr: 1.954 ± 0.028	0.0ArgXaa: 0.0 ± 0.0
Ser	6.8SerAla: 6.8 ± 0.058	0.375SerCys: 0.375 ± 0.012	2.471SerAsp: 2.471 ± 0.032	1.994SerGlu: 1.994 ± 0.031	1.46SerPhe: 1.46 ± 0.024	5.715SerGly: 5.715 ± 0.056	0.917SerHis: 0.917 ± 0.019	1.605SerIle: 1.605 ± 0.028	0.799SerLys: 0.799 ± 0.023	4.604SerLeu: 4.604 ± 0.047	1.013SerMet: 1.013 ± 0.017	0.817SerAsn: 0.817 ± 0.02	3.219SerPro: 3.219 ± 0.045	1.144SerGln: 1.144 ± 0.023	3.827SerArg: 3.827 ± 0.039	2.739SerSer: 2.739 ± 0.043	2.993SerThr: 2.993 ± 0.035	4.086SerVal: 4.086 ± 0.046	0.952SerTrp: 0.952 ± 0.023	1.082SerTyr: 1.082 ± 0.022	0.0SerXaa: 0.0 ± 0.0
Thr	9.052ThrAla: 9.052 ± 0.072	0.405ThrCys: 0.405 ± 0.014	3.474ThrAsp: 3.474 ± 0.038	2.82ThrGlu: 2.82 ± 0.036	1.762ThrPhe: 1.762 ± 0.03	6.73ThrGly: 6.73 ± 0.051	1.049ThrHis: 1.049 ± 0.02	2.074ThrIle: 2.074 ± 0.033	0.997ThrLys: 0.997 ± 0.026	5.757ThrLeu: 5.757 ± 0.053	1.005ThrMet: 1.005 ± 0.022	1.025ThrAsn: 1.025 ± 0.026	4.155ThrPro: 4.155 ± 0.047	1.244ThrGln: 1.244 ± 0.025	4.101ThrArg: 4.101 ± 0.043	3.057ThrSer: 3.057 ± 0.04	3.926ThrThr: 3.926 ± 0.052	6.477ThrVal: 6.477 ± 0.063	0.94ThrTrp: 0.94 ± 0.022	1.358ThrTyr: 1.358 ± 0.028	0.0ThrXaa: 0.0 ± 0.0
Val	12.612ValAla: 12.612 ± 0.091	0.642ValCys: 0.642 ± 0.016	5.201ValAsp: 5.201 ± 0.045	4.446ValGlu: 4.446 ± 0.049	2.261ValPhe: 2.261 ± 0.033	6.623ValGly: 6.623 ± 0.056	1.786ValHis: 1.786 ± 0.031	3.005ValIle: 3.005 ± 0.036	1.501ValLys: 1.501 ± 0.028	9.86ValLeu: 9.86 ± 0.081	1.239ValMet: 1.239 ± 0.022	1.674ValAsn: 1.674 ± 0.029	5.555ValPro: 5.555 ± 0.058	2.013ValGln: 2.013 ± 0.03	7.397ValArg: 7.397 ± 0.063	4.443ValSer: 4.443 ± 0.046	6.245ValThr: 6.245 ± 0.062	8.611ValVal: 8.611 ± 0.077	1.102ValTrp: 1.102 ± 0.02	1.488ValTyr: 1.488 ± 0.022	0.0ValXaa: 0.0 ± 0.0
Trp	1.72TrpAla: 1.72 ± 0.031	0.144TrpCys: 0.144 ± 0.007	0.748TrpAsp: 0.748 ± 0.018	0.641TrpGlu: 0.641 ± 0.015	0.482TrpPhe: 0.482 ± 0.013	0.993TrpGly: 0.993 ± 0.02	0.403TrpHis: 0.403 ± 0.014	0.58TrpIle: 0.58 ± 0.017	0.316TrpLys: 0.316 ± 0.012	1.794TrpLeu: 1.794 ± 0.032	0.29TrpMet: 0.29 ± 0.012	0.391TrpAsn: 0.391 ± 0.013	0.861TrpPro: 0.861 ± 0.021	0.64TrpGln: 0.64 ± 0.019	1.445TrpArg: 1.445 ± 0.024	0.991TrpSer: 0.991 ± 0.023	1.025TrpThr: 1.025 ± 0.021	1.018TrpVal: 1.018 ± 0.019	0.364TrpTrp: 0.364 ± 0.013	0.363TrpTyr: 0.363 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.974TyrAla: 2.974 ± 0.039	0.165TyrCys: 0.165 ± 0.008	1.409TyrAsp: 1.409 ± 0.029	1.079TyrGlu: 1.079 ± 0.021	0.629TyrPhe: 0.629 ± 0.02	2.161TyrGly: 2.161 ± 0.03	0.408TyrHis: 0.408 ± 0.013	0.399TyrIle: 0.399 ± 0.012	0.33TyrLys: 0.33 ± 0.013	2.249TyrLeu: 2.249 ± 0.03	0.203TyrMet: 0.203 ± 0.007	0.387TyrAsn: 0.387 ± 0.013	1.144TyrPro: 1.144 ± 0.021	0.586TyrGln: 0.586 ± 0.018	1.965TyrArg: 1.965 ± 0.027	0.887TyrSer: 0.887 ± 0.021	1.132TyrThr: 1.132 ± 0.024	1.759TyrVal: 1.759 ± 0.027	0.33TyrTrp: 0.33 ± 0.012	0.441TyrTyr: 0.441 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 7729 proteins (2588345 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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