Amino acid dipepetide frequency for Desulforhopalus sp. IMCC35007

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.516AlaAla: 7.516 ± 0.084	1.018AlaCys: 1.018 ± 0.034	4.309AlaAsp: 4.309 ± 0.059	5.324AlaGlu: 5.324 ± 0.059	3.192AlaPhe: 3.192 ± 0.055	6.532AlaGly: 6.532 ± 0.077	1.479AlaHis: 1.479 ± 0.029	5.804AlaIle: 5.804 ± 0.061	4.371AlaLys: 4.371 ± 0.06	8.201AlaLeu: 8.201 ± 0.077	2.364AlaMet: 2.364 ± 0.042	2.638AlaAsn: 2.638 ± 0.042	2.562AlaPro: 2.562 ± 0.037	2.597AlaGln: 2.597 ± 0.049	3.731AlaArg: 3.731 ± 0.056	4.571AlaSer: 4.571 ± 0.061	4.368AlaThr: 4.368 ± 0.055	5.883AlaVal: 5.883 ± 0.06	0.735AlaTrp: 0.735 ± 0.023	2.161AlaTyr: 2.161 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.9CysAla: 0.9 ± 0.021	0.305CysCys: 0.305 ± 0.016	0.597CysAsp: 0.597 ± 0.02	0.674CysGlu: 0.674 ± 0.021	0.548CysPhe: 0.548 ± 0.018	1.264CysGly: 1.264 ± 0.034	0.487CysHis: 0.487 ± 0.032	0.791CysIle: 0.791 ± 0.021	0.606CysLys: 0.606 ± 0.02	1.264CysLeu: 1.264 ± 0.03	0.312CysMet: 0.312 ± 0.017	0.476CysAsn: 0.476 ± 0.017	0.764CysPro: 0.764 ± 0.024	0.447CysGln: 0.447 ± 0.017	0.715CysArg: 0.715 ± 0.021	0.957CysSer: 0.957 ± 0.027	0.678CysThr: 0.678 ± 0.022	0.776CysVal: 0.776 ± 0.026	0.166CysTrp: 0.166 ± 0.011	0.401CysTyr: 0.401 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.634AspAla: 3.634 ± 0.06	0.689AspCys: 0.689 ± 0.019	2.773AspAsp: 2.773 ± 0.055	3.585AspGlu: 3.585 ± 0.054	2.609AspPhe: 2.609 ± 0.041	3.857AspGly: 3.857 ± 0.058	1.173AspHis: 1.173 ± 0.024	4.213AspIle: 4.213 ± 0.06	3.011AspLys: 3.011 ± 0.048	5.777AspLeu: 5.777 ± 0.06	1.294AspMet: 1.294 ± 0.03	2.192AspAsn: 2.192 ± 0.046	2.405AspPro: 2.405 ± 0.042	1.83AspGln: 1.83 ± 0.034	2.517AspArg: 2.517 ± 0.041	3.168AspSer: 3.168 ± 0.062	2.702AspThr: 2.702 ± 0.049	3.43AspVal: 3.43 ± 0.058	0.667AspTrp: 0.667 ± 0.021	1.871AspTyr: 1.871 ± 0.036	0.0AspXaa: 0.0 ± 0.0
Glu	5.023GluAla: 5.023 ± 0.066	0.594GluCys: 0.594 ± 0.018	3.246GluAsp: 3.246 ± 0.049	4.669GluGlu: 4.669 ± 0.067	2.273GluPhe: 2.273 ± 0.033	3.807GluGly: 3.807 ± 0.053	1.218GluHis: 1.218 ± 0.027	4.935GluIle: 4.935 ± 0.059	5.247GluLys: 5.247 ± 0.063	6.621GluLeu: 6.621 ± 0.067	1.868GluMet: 1.868 ± 0.037	3.198GluAsn: 3.198 ± 0.056	2.028GluPro: 2.028 ± 0.038	2.822GluGln: 2.822 ± 0.044	3.227GluArg: 3.227 ± 0.049	3.461GluSer: 3.461 ± 0.049	3.428GluThr: 3.428 ± 0.05	4.26GluVal: 4.26 ± 0.06	0.57GluTrp: 0.57 ± 0.017	1.824GluTyr: 1.824 ± 0.03	0.0GluXaa: 0.0 ± 0.0
Phe	3.275PheAla: 3.275 ± 0.048	0.717PheCys: 0.717 ± 0.022	2.543PheAsp: 2.543 ± 0.043	2.326PheGlu: 2.326 ± 0.042	2.47PhePhe: 2.47 ± 0.047	3.208PheGly: 3.208 ± 0.048	0.939PheHis: 0.939 ± 0.024	2.953PheIle: 2.953 ± 0.047	2.032PheLys: 2.032 ± 0.038	4.582PheLeu: 4.582 ± 0.071	1.061PheMet: 1.061 ± 0.029	1.705PheAsn: 1.705 ± 0.039	1.758PhePro: 1.758 ± 0.031	1.385PheGln: 1.385 ± 0.031	1.822PheArg: 1.822 ± 0.03	3.553PheSer: 3.553 ± 0.053	2.703PheThr: 2.703 ± 0.05	2.786PheVal: 2.786 ± 0.046	0.537PheTrp: 0.537 ± 0.018	1.41PheTyr: 1.41 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	5.5GlyAla: 5.5 ± 0.066	1.171GlyCys: 1.171 ± 0.032	3.609GlyAsp: 3.609 ± 0.06	4.382GlyGlu: 4.382 ± 0.058	3.296GlyPhe: 3.296 ± 0.049	5.517GlyGly: 5.517 ± 0.075	1.532GlyHis: 1.532 ± 0.031	5.417GlyIle: 5.417 ± 0.066	4.725GlyLys: 4.725 ± 0.062	7.431GlyLeu: 7.431 ± 0.079	2.1GlyMet: 2.1 ± 0.038	2.683GlyAsn: 2.683 ± 0.042	2.157GlyPro: 2.157 ± 0.035	2.516GlyGln: 2.516 ± 0.04	3.526GlyArg: 3.526 ± 0.048	4.516GlySer: 4.516 ± 0.057	4.043GlyThr: 4.043 ± 0.054	5.313GlyVal: 5.313 ± 0.065	0.875GlyTrp: 0.875 ± 0.024	2.652GlyTyr: 2.652 ± 0.046	0.0GlyXaa: 0.0 ± 0.0
His	1.386HisAla: 1.386 ± 0.032	0.363HisCys: 0.363 ± 0.015	1.074HisAsp: 1.074 ± 0.028	1.162HisGlu: 1.162 ± 0.029	1.044HisPhe: 1.044 ± 0.028	1.556HisGly: 1.556 ± 0.035	0.553HisHis: 0.553 ± 0.023	1.374HisIle: 1.374 ± 0.029	1.063HisLys: 1.063 ± 0.027	2.295HisLeu: 2.295 ± 0.043	0.451HisMet: 0.451 ± 0.016	0.842HisAsn: 0.842 ± 0.026	1.159HisPro: 1.159 ± 0.027	0.782HisGln: 0.782 ± 0.022	1.071HisArg: 1.071 ± 0.023	1.359HisSer: 1.359 ± 0.03	1.01HisThr: 1.01 ± 0.024	1.206HisVal: 1.206 ± 0.029	0.258HisTrp: 0.258 ± 0.013	0.758HisTyr: 0.758 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	5.892IleAla: 5.892 ± 0.072	0.976IleCys: 0.976 ± 0.023	4.068IleAsp: 4.068 ± 0.058	4.589IleGlu: 4.589 ± 0.056	3.144IlePhe: 3.144 ± 0.052	5.048IleGly: 5.048 ± 0.069	1.523IleHis: 1.523 ± 0.033	4.833IleIle: 4.833 ± 0.066	3.537IleLys: 3.537 ± 0.051	7.044IleLeu: 7.044 ± 0.075	1.525IleMet: 1.525 ± 0.035	2.834IleAsn: 2.834 ± 0.05	3.179IlePro: 3.179 ± 0.045	2.312IleGln: 2.312 ± 0.04	3.35IleArg: 3.35 ± 0.047	4.944IleSer: 4.944 ± 0.051	4.184IleThr: 4.184 ± 0.059	4.908IleVal: 4.908 ± 0.064	0.639IleTrp: 0.639 ± 0.025	1.966IleTyr: 1.966 ± 0.035	0.0IleXaa: 0.0 ± 0.0
Lys	4.415LysAla: 4.415 ± 0.055	0.522LysCys: 0.522 ± 0.02	3.26LysAsp: 3.26 ± 0.052	4.404LysGlu: 4.404 ± 0.058	1.692LysPhe: 1.692 ± 0.035	3.863LysGly: 3.863 ± 0.048	1.025LysHis: 1.025 ± 0.026	4.552LysIle: 4.552 ± 0.053	4.81LysLys: 4.81 ± 0.069	4.869LysLeu: 4.869 ± 0.059	1.755LysMet: 1.755 ± 0.034	2.959LysAsn: 2.959 ± 0.041	2.106LysPro: 2.106 ± 0.034	2.119LysGln: 2.119 ± 0.041	2.916LysArg: 2.916 ± 0.048	3.295LysSer: 3.295 ± 0.047	3.443LysThr: 3.443 ± 0.047	3.794LysVal: 3.794 ± 0.052	0.52LysTrp: 0.52 ± 0.019	1.71LysTyr: 1.71 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	9.104LeuAla: 9.104 ± 0.08	1.375LeuCys: 1.375 ± 0.032	5.325LeuAsp: 5.325 ± 0.064	6.367LeuGlu: 6.367 ± 0.07	4.777LeuPhe: 4.777 ± 0.073	7.189LeuGly: 7.189 ± 0.074	2.138LeuHis: 2.138 ± 0.042	6.567LeuIle: 6.567 ± 0.067	5.807LeuLys: 5.807 ± 0.067	11.242LeuLeu: 11.242 ± 0.126	2.404LeuMet: 2.404 ± 0.042	3.698LeuAsn: 3.698 ± 0.052	4.718LeuPro: 4.718 ± 0.058	4.202LeuGln: 4.202 ± 0.058	4.872LeuArg: 4.872 ± 0.061	7.442LeuSer: 7.442 ± 0.078	5.885LeuThr: 5.885 ± 0.063	6.688LeuVal: 6.688 ± 0.069	0.954LeuTrp: 0.954 ± 0.026	2.763LeuTyr: 2.763 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.557MetAla: 2.557 ± 0.047	0.239MetCys: 0.239 ± 0.014	1.369MetAsp: 1.369 ± 0.031	1.607MetGlu: 1.607 ± 0.027	0.9MetPhe: 0.9 ± 0.025	1.891MetGly: 1.891 ± 0.034	0.435MetHis: 0.435 ± 0.016	1.668MetIle: 1.668 ± 0.035	1.783MetLys: 1.783 ± 0.036	2.404MetLeu: 2.404 ± 0.042	0.705MetMet: 0.705 ± 0.023	1.104MetAsn: 1.104 ± 0.026	1.034MetPro: 1.034 ± 0.026	0.987MetGln: 0.987 ± 0.026	1.209MetArg: 1.209 ± 0.027	1.678MetSer: 1.678 ± 0.032	1.545MetThr: 1.545 ± 0.029	1.997MetVal: 1.997 ± 0.038	0.177MetTrp: 0.177 ± 0.011	0.609MetTyr: 0.609 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.531AsnAla: 2.531 ± 0.042	0.601AsnCys: 0.601 ± 0.021	1.993AsnAsp: 1.993 ± 0.049	2.14AsnGlu: 2.14 ± 0.044	1.603AsnPhe: 1.603 ± 0.036	2.807AsnGly: 2.807 ± 0.046	0.846AsnHis: 0.846 ± 0.024	3.155AsnIle: 3.155 ± 0.048	2.085AsnLys: 2.085 ± 0.039	4.149AsnLeu: 4.149 ± 0.053	0.991AsnMet: 0.991 ± 0.024	1.792AsnAsn: 1.792 ± 0.035	2.019AsnPro: 2.019 ± 0.029	1.402AsnGln: 1.402 ± 0.03	2.132AsnArg: 2.132 ± 0.037	2.574AsnSer: 2.574 ± 0.05	2.067AsnThr: 2.067 ± 0.04	2.457AsnVal: 2.457 ± 0.044	0.464AsnTrp: 0.464 ± 0.017	1.319AsnTyr: 1.319 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	3.307ProAla: 3.307 ± 0.043	0.426ProCys: 0.426 ± 0.018	2.582ProAsp: 2.582 ± 0.04	3.542ProGlu: 3.542 ± 0.051	1.912ProPhe: 1.912 ± 0.032	3.27ProGly: 3.27 ± 0.046	0.843ProHis: 0.843 ± 0.026	2.356ProIle: 2.356 ± 0.042	1.975ProLys: 1.975 ± 0.036	4.169ProLeu: 4.169 ± 0.055	0.96ProMet: 0.96 ± 0.026	1.183ProAsn: 1.183 ± 0.03	1.679ProPro: 1.679 ± 0.035	1.511ProGln: 1.511 ± 0.032	1.505ProArg: 1.505 ± 0.034	2.259ProSer: 2.259 ± 0.035	2.006ProThr: 2.006 ± 0.037	3.55ProVal: 3.55 ± 0.053	0.456ProTrp: 0.456 ± 0.016	1.258ProTyr: 1.258 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.084GlnAla: 3.084 ± 0.048	0.387GlnCys: 0.387 ± 0.017	1.706GlnAsp: 1.706 ± 0.035	2.497GlnGlu: 2.497 ± 0.044	1.459GlnPhe: 1.459 ± 0.03	2.367GlnGly: 2.367 ± 0.039	0.763GlnHis: 0.763 ± 0.022	2.436GlnIle: 2.436 ± 0.038	2.539GlnLys: 2.539 ± 0.044	3.995GlnLeu: 3.995 ± 0.062	1.058GlnMet: 1.058 ± 0.023	1.513GlnAsn: 1.513 ± 0.033	1.412GlnPro: 1.412 ± 0.035	1.855GlnGln: 1.855 ± 0.039	1.919GlnArg: 1.919 ± 0.032	2.19GlnSer: 2.19 ± 0.037	1.941GlnThr: 1.941 ± 0.036	2.488GlnVal: 2.488 ± 0.037	0.41GlnTrp: 0.41 ± 0.017	1.054GlnTyr: 1.054 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.277ArgAla: 3.277 ± 0.043	0.607ArgCys: 0.607 ± 0.02	2.476ArgAsp: 2.476 ± 0.044	3.353ArgGlu: 3.353 ± 0.05	2.25ArgPhe: 2.25 ± 0.039	2.866ArgGly: 2.866 ± 0.042	1.031ArgHis: 1.031 ± 0.026	3.536ArgIle: 3.536 ± 0.049	3.081ArgLys: 3.081 ± 0.049	5.279ArgLeu: 5.279 ± 0.067	1.307ArgMet: 1.307 ± 0.033	1.954ArgAsn: 1.954 ± 0.03	1.815ArgPro: 1.815 ± 0.033	2.152ArgGln: 2.152 ± 0.036	2.5ArgArg: 2.5 ± 0.047	2.848ArgSer: 2.848 ± 0.043	2.353ArgThr: 2.353 ± 0.036	3.109ArgVal: 3.109 ± 0.045	0.518ArgTrp: 0.518 ± 0.018	1.724ArgTyr: 1.724 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	4.698SerAla: 4.698 ± 0.061	0.901SerCys: 0.901 ± 0.026	3.296SerAsp: 3.296 ± 0.063	3.666SerGlu: 3.666 ± 0.047	3.182SerPhe: 3.182 ± 0.048	5.52SerGly: 5.52 ± 0.072	1.417SerHis: 1.417 ± 0.028	4.42SerIle: 4.42 ± 0.057	3.095SerLys: 3.095 ± 0.044	6.929SerLeu: 6.929 ± 0.074	1.711SerMet: 1.711 ± 0.035	2.161SerAsn: 2.161 ± 0.04	2.732SerPro: 2.732 ± 0.043	2.331SerGln: 2.331 ± 0.032	3.133SerArg: 3.133 ± 0.044	4.408SerSer: 4.408 ± 0.057	3.428SerThr: 3.428 ± 0.051	4.198SerVal: 4.198 ± 0.056	0.816SerTrp: 0.816 ± 0.025	2.073SerTyr: 2.073 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	4.486ThrAla: 4.486 ± 0.058	0.677ThrCys: 0.677 ± 0.02	2.99ThrAsp: 2.99 ± 0.058	3.197ThrGlu: 3.197 ± 0.05	2.355ThrPhe: 2.355 ± 0.039	4.765ThrGly: 4.765 ± 0.06	1.094ThrHis: 1.094 ± 0.026	4.211ThrIle: 4.211 ± 0.051	2.558ThrLys: 2.558 ± 0.044	5.809ThrLeu: 5.809 ± 0.07	1.353ThrMet: 1.353 ± 0.031	1.908ThrAsn: 1.908 ± 0.047	2.744ThrPro: 2.744 ± 0.043	1.603ThrGln: 1.603 ± 0.03	2.456ThrArg: 2.456 ± 0.042	3.471ThrSer: 3.471 ± 0.055	3.412ThrThr: 3.412 ± 0.058	4.292ThrVal: 4.292 ± 0.075	0.557ThrTrp: 0.557 ± 0.022	1.515ThrTyr: 1.515 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	6.019ValAla: 6.019 ± 0.061	0.947ValCys: 0.947 ± 0.027	4.027ValAsp: 4.027 ± 0.056	4.547ValGlu: 4.547 ± 0.059	3.033ValPhe: 3.033 ± 0.045	4.639ValGly: 4.639 ± 0.065	1.355ValHis: 1.355 ± 0.03	4.855ValIle: 4.855 ± 0.056	3.582ValLys: 3.582 ± 0.05	6.822ValLeu: 6.822 ± 0.081	1.743ValMet: 1.743 ± 0.033	2.561ValAsn: 2.561 ± 0.046	2.68ValPro: 2.68 ± 0.038	2.329ValGln: 2.329 ± 0.038	3.152ValArg: 3.152 ± 0.043	4.647ValSer: 4.647 ± 0.055	4.057ValThr: 4.057 ± 0.064	5.456ValVal: 5.456 ± 0.071	0.66ValTrp: 0.66 ± 0.022	1.859ValTyr: 1.859 ± 0.036	0.0ValXaa: 0.0 ± 0.0
Trp	0.713TrpAla: 0.713 ± 0.021	0.13TrpCys: 0.13 ± 0.009	0.506TrpAsp: 0.506 ± 0.019	0.596TrpGlu: 0.596 ± 0.018	0.495TrpPhe: 0.495 ± 0.023	0.712TrpGly: 0.712 ± 0.021	0.232TrpHis: 0.232 ± 0.012	0.663TrpIle: 0.663 ± 0.023	0.638TrpLys: 0.638 ± 0.02	1.215TrpLeu: 1.215 ± 0.03	0.283TrpMet: 0.283 ± 0.013	0.45TrpAsn: 0.45 ± 0.019	0.435TrpPro: 0.435 ± 0.016	0.578TrpGln: 0.578 ± 0.021	0.534TrpArg: 0.534 ± 0.019	0.637TrpSer: 0.637 ± 0.019	0.489TrpThr: 0.489 ± 0.019	0.676TrpVal: 0.676 ± 0.021	0.142TrpTrp: 0.142 ± 0.01	0.347TrpTyr: 0.347 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.04TyrAla: 2.04 ± 0.039	0.486TyrCys: 0.486 ± 0.016	1.648TyrAsp: 1.648 ± 0.033	1.689TyrGlu: 1.689 ± 0.034	1.53TyrPhe: 1.53 ± 0.033	2.283TyrGly: 2.283 ± 0.037	0.679TyrHis: 0.679 ± 0.02	1.758TyrIle: 1.758 ± 0.04	1.483TyrLys: 1.483 ± 0.029	3.418TyrLeu: 3.418 ± 0.051	0.65TyrMet: 0.65 ± 0.022	1.275TyrAsn: 1.275 ± 0.032	1.362TyrPro: 1.362 ± 0.03	1.314TyrGln: 1.314 ± 0.03	1.748TyrArg: 1.748 ± 0.033	2.137TyrSer: 2.137 ± 0.039	1.712TyrThr: 1.712 ± 0.045	1.704TyrVal: 1.704 ± 0.029	0.353TyrTrp: 0.353 ± 0.017	1.104TyrTyr: 1.104 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4843 proteins (1630847 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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