Amino acid dipepetide frequency for Oceanispirochaeta crateris

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.47AlaAla: 5.47 ± 0.095	0.676AlaCys: 0.676 ± 0.025	3.481AlaAsp: 3.481 ± 0.061	4.471AlaGlu: 4.471 ± 0.074	2.892AlaPhe: 2.892 ± 0.051	5.549AlaGly: 5.549 ± 0.083	1.131AlaHis: 1.131 ± 0.035	4.192AlaIle: 4.192 ± 0.074	2.775AlaLys: 2.775 ± 0.061	8.042AlaLeu: 8.042 ± 0.09	1.832AlaMet: 1.832 ± 0.043	1.915AlaAsn: 1.915 ± 0.048	2.034AlaPro: 2.034 ± 0.043	2.016AlaGln: 2.016 ± 0.043	2.992AlaArg: 2.992 ± 0.059	4.587AlaSer: 4.587 ± 0.074	2.503AlaThr: 2.503 ± 0.057	5.056AlaVal: 5.056 ± 0.076	0.667AlaTrp: 0.667 ± 0.024	2.017AlaTyr: 2.017 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	0.562CysAla: 0.562 ± 0.02	0.141CysCys: 0.141 ± 0.012	0.539CysAsp: 0.539 ± 0.023	0.513CysGlu: 0.513 ± 0.02	0.482CysPhe: 0.482 ± 0.02	0.965CysGly: 0.965 ± 0.035	0.246CysHis: 0.246 ± 0.014	0.654CysIle: 0.654 ± 0.021	0.413CysLys: 0.413 ± 0.021	1.002CysLeu: 1.002 ± 0.029	0.213CysMet: 0.213 ± 0.012	0.316CysAsn: 0.316 ± 0.015	0.553CysPro: 0.553 ± 0.023	0.3CysGln: 0.3 ± 0.014	0.659CysArg: 0.659 ± 0.025	0.837CysSer: 0.837 ± 0.029	0.475CysThr: 0.475 ± 0.02	0.462CysVal: 0.462 ± 0.018	0.09CysTrp: 0.09 ± 0.009	0.367CysTyr: 0.367 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.224AspAla: 3.224 ± 0.057	0.548AspCys: 0.548 ± 0.021	3.095AspAsp: 3.095 ± 0.088	4.207AspGlu: 4.207 ± 0.08	3.13AspPhe: 3.13 ± 0.054	3.603AspGly: 3.603 ± 0.073	1.191AspHis: 1.191 ± 0.037	4.217AspIle: 4.217 ± 0.057	3.215AspLys: 3.215 ± 0.053	6.571AspLeu: 6.571 ± 0.093	1.563AspMet: 1.563 ± 0.035	2.054AspAsn: 2.054 ± 0.047	2.449AspPro: 2.449 ± 0.043	2.014AspGln: 2.014 ± 0.048	2.797AspArg: 2.797 ± 0.054	4.149AspSer: 4.149 ± 0.061	2.414AspThr: 2.414 ± 0.056	3.12AspVal: 3.12 ± 0.057	0.687AspTrp: 0.687 ± 0.023	2.189AspTyr: 2.189 ± 0.046	0.0AspXaa: 0.0 ± 0.0
Glu	4.824GluAla: 4.824 ± 0.069	0.501GluCys: 0.501 ± 0.02	4.209GluAsp: 4.209 ± 0.071	6.134GluGlu: 6.134 ± 0.095	2.563GluPhe: 2.563 ± 0.05	4.651GluGly: 4.651 ± 0.063	1.032GluHis: 1.032 ± 0.029	5.722GluIle: 5.722 ± 0.079	5.597GluLys: 5.597 ± 0.071	6.752GluLeu: 6.752 ± 0.082	2.186GluMet: 2.186 ± 0.043	3.81GluAsn: 3.81 ± 0.06	1.776GluPro: 1.776 ± 0.037	2.366GluGln: 2.366 ± 0.053	2.917GluArg: 2.917 ± 0.055	4.912GluSer: 4.912 ± 0.067	3.67GluThr: 3.67 ± 0.052	3.878GluVal: 3.878 ± 0.051	0.646GluTrp: 0.646 ± 0.026	2.485GluTyr: 2.485 ± 0.046	0.0GluXaa: 0.0 ± 0.0
Phe	2.572PheAla: 2.572 ± 0.044	0.555PheCys: 0.555 ± 0.021	2.47PheAsp: 2.47 ± 0.045	2.534PheGlu: 2.534 ± 0.05	2.598PhePhe: 2.598 ± 0.057	2.951PheGly: 2.951 ± 0.062	0.976PheHis: 0.976 ± 0.027	3.646PheIle: 3.646 ± 0.07	2.426PheLys: 2.426 ± 0.048	5.529PheLeu: 5.529 ± 0.082	1.249PheMet: 1.249 ± 0.033	1.968PheAsn: 1.968 ± 0.045	1.989PhePro: 1.989 ± 0.035	1.594PheGln: 1.594 ± 0.036	2.167PheArg: 2.167 ± 0.046	4.315PheSer: 4.315 ± 0.068	2.527PheThr: 2.527 ± 0.047	2.429PheVal: 2.429 ± 0.049	0.514PheTrp: 0.514 ± 0.018	1.762PheTyr: 1.762 ± 0.041	0.0PheXaa: 0.0 ± 0.0
Gly	4.628GlyAla: 4.628 ± 0.081	0.802GlyCys: 0.802 ± 0.031	3.67GlyAsp: 3.67 ± 0.056	4.405GlyGlu: 4.405 ± 0.058	3.66GlyPhe: 3.66 ± 0.057	4.908GlyGly: 4.908 ± 0.1	1.361GlyHis: 1.361 ± 0.035	6.297GlyIle: 6.297 ± 0.077	4.367GlyLys: 4.367 ± 0.066	7.131GlyLeu: 7.131 ± 0.09	2.219GlyMet: 2.219 ± 0.046	2.825GlyAsn: 2.825 ± 0.062	1.91GlyPro: 1.91 ± 0.043	2.231GlyGln: 2.231 ± 0.047	3.265GlyArg: 3.265 ± 0.053	4.798GlySer: 4.798 ± 0.08	3.811GlyThr: 3.811 ± 0.099	4.447GlyVal: 4.447 ± 0.061	0.839GlyTrp: 0.839 ± 0.028	2.677GlyTyr: 2.677 ± 0.05	0.0GlyXaa: 0.0 ± 0.0
His	0.938HisAla: 0.938 ± 0.029	0.228HisCys: 0.228 ± 0.014	0.949HisAsp: 0.949 ± 0.032	1.081HisGlu: 1.081 ± 0.034	1.072HisPhe: 1.072 ± 0.035	1.188HisGly: 1.188 ± 0.034	0.474HisHis: 0.474 ± 0.022	1.393HisIle: 1.393 ± 0.037	1.115HisLys: 1.115 ± 0.03	1.896HisLeu: 1.896 ± 0.041	0.459HisMet: 0.459 ± 0.019	0.798HisAsn: 0.798 ± 0.028	1.093HisPro: 1.093 ± 0.033	0.682HisGln: 0.682 ± 0.021	0.901HisArg: 0.901 ± 0.025	1.371HisSer: 1.371 ± 0.038	0.846HisThr: 0.846 ± 0.026	0.848HisVal: 0.848 ± 0.027	0.261HisTrp: 0.261 ± 0.018	0.746HisTyr: 0.746 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	4.826IleAla: 4.826 ± 0.078	0.837IleCys: 0.837 ± 0.027	4.082IleAsp: 4.082 ± 0.06	4.787IleGlu: 4.787 ± 0.06	3.416IlePhe: 3.416 ± 0.064	4.614IleGly: 4.614 ± 0.074	1.653IleHis: 1.653 ± 0.042	5.747IleIle: 5.747 ± 0.091	4.279IleLys: 4.279 ± 0.061	9.477IleLeu: 9.477 ± 0.108	1.943IleMet: 1.943 ± 0.046	3.225IleAsn: 3.225 ± 0.059	4.172IlePro: 4.172 ± 0.067	2.975IleGln: 2.975 ± 0.049	3.931IleArg: 3.931 ± 0.064	6.182IleSer: 6.182 ± 0.069	3.747IleThr: 3.747 ± 0.055	4.164IleVal: 4.164 ± 0.071	0.555IleTrp: 0.555 ± 0.021	2.308IleTyr: 2.308 ± 0.045	0.0IleXaa: 0.0 ± 0.0
Lys	4.35LysAla: 4.35 ± 0.071	0.372LysCys: 0.372 ± 0.018	3.888LysAsp: 3.888 ± 0.054	5.684LysGlu: 5.684 ± 0.086	1.613LysPhe: 1.613 ± 0.036	4.398LysGly: 4.398 ± 0.067	0.877LysHis: 0.877 ± 0.028	4.866LysIle: 4.866 ± 0.069	5.208LysLys: 5.208 ± 0.085	4.743LysLeu: 4.743 ± 0.057	1.923LysMet: 1.923 ± 0.041	3.336LysAsn: 3.336 ± 0.059	1.966LysPro: 1.966 ± 0.041	1.924LysGln: 1.924 ± 0.04	2.829LysArg: 2.829 ± 0.053	4.031LysSer: 4.031 ± 0.063	3.565LysThr: 3.565 ± 0.056	3.481LysVal: 3.481 ± 0.051	0.561LysTrp: 0.561 ± 0.021	1.812LysTyr: 1.812 ± 0.044	0.0LysXaa: 0.0 ± 0.0
Leu	6.756LeuAla: 6.756 ± 0.083	1.089LeuCys: 1.089 ± 0.03	6.008LeuAsp: 6.008 ± 0.09	7.457LeuGlu: 7.457 ± 0.09	5.397LeuPhe: 5.397 ± 0.089	6.904LeuGly: 6.904 ± 0.084	1.714LeuHis: 1.714 ± 0.039	8.26LeuIle: 8.26 ± 0.105	7.644LeuLys: 7.644 ± 0.086	10.89LeuLeu: 10.89 ± 0.128	3.036LeuMet: 3.036 ± 0.045	5.049LeuAsn: 5.049 ± 0.074	4.549LeuPro: 4.549 ± 0.066	3.318LeuGln: 3.318 ± 0.051	4.224LeuArg: 4.224 ± 0.065	8.869LeuSer: 8.869 ± 0.093	5.542LeuThr: 5.542 ± 0.094	5.92LeuVal: 5.92 ± 0.075	1.054LeuTrp: 1.054 ± 0.033	3.587LeuTyr: 3.587 ± 0.053	0.0LeuXaa: 0.0 ± 0.0
Met	2.269MetAla: 2.269 ± 0.045	0.181MetCys: 0.181 ± 0.013	1.917MetAsp: 1.917 ± 0.04	2.174MetGlu: 2.174 ± 0.038	0.856MetPhe: 0.856 ± 0.03	2.153MetGly: 2.153 ± 0.048	0.367MetHis: 0.367 ± 0.016	2.392MetIle: 2.392 ± 0.046	2.504MetLys: 2.504 ± 0.045	2.069MetLeu: 2.069 ± 0.039	0.856MetMet: 0.856 ± 0.032	1.682MetAsn: 1.682 ± 0.044	0.956MetPro: 0.956 ± 0.029	0.693MetGln: 0.693 ± 0.027	1.1MetArg: 1.1 ± 0.033	1.814MetSer: 1.814 ± 0.043	1.777MetThr: 1.777 ± 0.044	1.784MetVal: 1.784 ± 0.043	0.159MetTrp: 0.159 ± 0.012	0.582MetTyr: 0.582 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	2.378AsnAla: 2.378 ± 0.049	0.463AsnCys: 0.463 ± 0.017	2.22AsnAsp: 2.22 ± 0.046	2.678AsnGlu: 2.678 ± 0.047	1.817AsnPhe: 1.817 ± 0.037	2.669AsnGly: 2.669 ± 0.053	0.944AsnHis: 0.944 ± 0.03	3.397AsnIle: 3.397 ± 0.06	2.566AsnLys: 2.566 ± 0.046	4.768AsnLeu: 4.768 ± 0.065	1.23AsnMet: 1.23 ± 0.03	1.755AsnAsn: 1.755 ± 0.044	2.444AsnPro: 2.444 ± 0.048	1.684AsnGln: 1.684 ± 0.037	2.524AsnArg: 2.524 ± 0.048	3.004AsnSer: 3.004 ± 0.059	2.125AsnThr: 2.125 ± 0.053	2.091AsnVal: 2.091 ± 0.044	0.534AsnTrp: 0.534 ± 0.021	1.473AsnTyr: 1.473 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	2.382ProAla: 2.382 ± 0.049	0.325ProCys: 0.325 ± 0.019	2.698ProAsp: 2.698 ± 0.056	3.786ProGlu: 3.786 ± 0.069	2.011ProPhe: 2.011 ± 0.039	3.537ProGly: 3.537 ± 0.059	0.8ProHis: 0.8 ± 0.025	2.162ProIle: 2.162 ± 0.042	1.367ProLys: 1.367 ± 0.033	4.454ProLeu: 4.454 ± 0.066	0.899ProMet: 0.899 ± 0.026	1.076ProAsn: 1.076 ± 0.028	1.393ProPro: 1.393 ± 0.037	1.319ProGln: 1.319 ± 0.031	1.481ProArg: 1.481 ± 0.04	2.669ProSer: 2.669 ± 0.048	1.469ProThr: 1.469 ± 0.039	3.281ProVal: 3.281 ± 0.056	0.521ProTrp: 0.521 ± 0.02	1.417ProTyr: 1.417 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	2.232GlnAla: 2.232 ± 0.051	0.246GlnCys: 0.246 ± 0.015	2.035GlnAsp: 2.035 ± 0.041	2.578GlnGlu: 2.578 ± 0.055	1.489GlnPhe: 1.489 ± 0.039	2.322GlnGly: 2.322 ± 0.045	0.456GlnHis: 0.456 ± 0.02	2.725GlnIle: 2.725 ± 0.046	2.587GlnLys: 2.587 ± 0.048	2.962GlnLeu: 2.962 ± 0.052	0.989GlnMet: 0.989 ± 0.029	1.786GlnAsn: 1.786 ± 0.039	0.909GlnPro: 0.909 ± 0.026	1.124GlnGln: 1.124 ± 0.039	1.437GlnArg: 1.437 ± 0.035	2.318GlnSer: 2.318 ± 0.05	1.671GlnThr: 1.671 ± 0.043	1.915GlnVal: 1.915 ± 0.037	0.413GlnTrp: 0.413 ± 0.021	1.165GlnTyr: 1.165 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	2.494ArgAla: 2.494 ± 0.049	0.397ArgCys: 0.397 ± 0.019	2.683ArgAsp: 2.683 ± 0.052	3.636ArgGlu: 3.636 ± 0.055	2.316ArgPhe: 2.316 ± 0.047	2.936ArgGly: 2.936 ± 0.052	0.827ArgHis: 0.827 ± 0.025	4.14ArgIle: 4.14 ± 0.061	3.323ArgLys: 3.323 ± 0.051	4.458ArgLeu: 4.458 ± 0.059	1.457ArgMet: 1.457 ± 0.036	2.225ArgAsn: 2.225 ± 0.044	1.406ArgPro: 1.406 ± 0.038	1.651ArgGln: 1.651 ± 0.038	2.097ArgArg: 2.097 ± 0.043	3.071ArgSer: 3.071 ± 0.049	2.222ArgThr: 2.222 ± 0.044	2.868ArgVal: 2.868 ± 0.049	0.504ArgTrp: 0.504 ± 0.023	1.695ArgTyr: 1.695 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	4.423SerAla: 4.423 ± 0.068	0.866SerCys: 0.866 ± 0.032	3.968SerAsp: 3.968 ± 0.064	4.816SerGlu: 4.816 ± 0.07	3.957SerPhe: 3.957 ± 0.059	5.934SerGly: 5.934 ± 0.089	1.407SerHis: 1.407 ± 0.036	5.499SerIle: 5.499 ± 0.077	3.354SerLys: 3.354 ± 0.066	9.12SerLeu: 9.12 ± 0.1	2.101SerMet: 2.101 ± 0.04	2.431SerAsn: 2.431 ± 0.044	2.79SerPro: 2.79 ± 0.05	2.505SerGln: 2.505 ± 0.054	3.985SerArg: 3.985 ± 0.061	5.817SerSer: 5.817 ± 0.089	3.143SerThr: 3.143 ± 0.067	4.578SerVal: 4.578 ± 0.065	0.967SerTrp: 0.967 ± 0.028	2.571SerTyr: 2.571 ± 0.047	0.0SerXaa: 0.0 ± 0.0
Thr	3.915ThrAla: 3.915 ± 0.076	0.364ThrCys: 0.364 ± 0.02	2.617ThrAsp: 2.617 ± 0.051	3.128ThrGlu: 3.128 ± 0.053	2.002ThrPhe: 2.002 ± 0.041	4.468ThrGly: 4.468 ± 0.078	0.906ThrHis: 0.906 ± 0.028	3.896ThrIle: 3.896 ± 0.067	2.228ThrLys: 2.228 ± 0.045	5.709ThrLeu: 5.709 ± 0.08	1.276ThrMet: 1.276 ± 0.032	1.695ThrAsn: 1.695 ± 0.042	2.307ThrPro: 2.307 ± 0.047	1.374ThrGln: 1.374 ± 0.036	2.104ThrArg: 2.104 ± 0.044	3.366ThrSer: 3.366 ± 0.061	2.396ThrThr: 2.396 ± 0.059	3.609ThrVal: 3.609 ± 0.076	0.489ThrTrp: 0.489 ± 0.022	1.395ThrTyr: 1.395 ± 0.036	0.0ThrXaa: 0.0 ± 0.0
Val	3.583ValAla: 3.583 ± 0.061	0.69ValCys: 0.69 ± 0.028	3.262ValAsp: 3.262 ± 0.055	3.768ValGlu: 3.768 ± 0.069	3.14ValPhe: 3.14 ± 0.058	3.389ValGly: 3.389 ± 0.06	1.118ValHis: 1.118 ± 0.031	4.613ValIle: 4.613 ± 0.065	3.618ValLys: 3.618 ± 0.056	7.112ValLeu: 7.112 ± 0.085	1.709ValMet: 1.709 ± 0.034	2.634ValAsn: 2.634 ± 0.052	2.439ValPro: 2.439 ± 0.05	1.987ValGln: 1.987 ± 0.041	2.733ValArg: 2.733 ± 0.049	4.73ValSer: 4.73 ± 0.057	2.957ValThr: 2.957 ± 0.058	3.773ValVal: 3.773 ± 0.066	0.546ValTrp: 0.546 ± 0.021	2.105ValTyr: 2.105 ± 0.043	0.0ValXaa: 0.0 ± 0.0
Trp	0.583TrpAla: 0.583 ± 0.025	0.117TrpCys: 0.117 ± 0.011	0.686TrpAsp: 0.686 ± 0.027	0.775TrpGlu: 0.775 ± 0.027	0.518TrpPhe: 0.518 ± 0.02	0.774TrpGly: 0.774 ± 0.027	0.178TrpHis: 0.178 ± 0.013	0.769TrpIle: 0.769 ± 0.025	0.768TrpLys: 0.768 ± 0.024	0.941TrpLeu: 0.941 ± 0.032	0.322TrpMet: 0.322 ± 0.016	0.587TrpAsn: 0.587 ± 0.023	0.321TrpPro: 0.321 ± 0.017	0.396TrpGln: 0.396 ± 0.018	0.405TrpArg: 0.405 ± 0.017	0.736TrpSer: 0.736 ± 0.025	0.539TrpThr: 0.539 ± 0.023	0.604TrpVal: 0.604 ± 0.025	0.134TrpTrp: 0.134 ± 0.01	0.368TrpTyr: 0.368 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.889TyrAla: 1.889 ± 0.038	0.391TyrCys: 0.391 ± 0.018	1.959TyrAsp: 1.959 ± 0.043	2.016TyrGlu: 2.016 ± 0.041	1.844TyrPhe: 1.844 ± 0.045	2.337TyrGly: 2.337 ± 0.049	0.687TyrHis: 0.687 ± 0.026	2.336TyrIle: 2.336 ± 0.045	2.071TyrLys: 2.071 ± 0.043	3.641TyrLeu: 3.641 ± 0.061	0.823TyrMet: 0.823 ± 0.027	1.597TyrAsn: 1.597 ± 0.038	1.592TyrPro: 1.592 ± 0.037	1.206TyrGln: 1.206 ± 0.035	1.858TyrArg: 1.858 ± 0.042	2.654TyrSer: 2.654 ± 0.053	1.846TyrThr: 1.846 ± 0.044	1.597TyrVal: 1.597 ± 0.041	0.378TyrTrp: 0.378 ± 0.019	1.393TyrTyr: 1.393 ± 0.04	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3504 proteins (1208583 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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