Amino acid dipepetide frequency for Corynebacterium phage Adelaide

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
20.826AlaAla: 20.826 ± 2.404
0.51AlaCys: 0.51 ± 0.194
9.758AlaAsp: 9.758 ± 0.934
9.685AlaGlu: 9.685 ± 1.041
2.913AlaPhe: 2.913 ± 0.573
10.995AlaGly: 10.995 ± 1.261
1.748AlaHis: 1.748 ± 0.401
6.044AlaIle: 6.044 ± 0.819
4.078AlaLys: 4.078 ± 0.652
10.85AlaLeu: 10.85 ± 0.953
4.223AlaMet: 4.223 ± 0.653
2.403AlaAsn: 2.403 ± 0.691
7.355AlaPro: 7.355 ± 0.73
5.024AlaGln: 5.024 ± 0.79
7.355AlaArg: 7.355 ± 0.822
5.388AlaSer: 5.388 ± 0.643
6.554AlaThr: 6.554 ± 0.584
8.301AlaVal: 8.301 ± 0.892
2.621AlaTrp: 2.621 ± 0.499
2.767AlaTyr: 2.767 ± 0.517
0.0AlaXaa: 0.0 ± 0.0
Cys
0.364CysAla: 0.364 ± 0.19
0.073CysCys: 0.073 ± 0.084
0.291CysAsp: 0.291 ± 0.143
0.364CysGlu: 0.364 ± 0.164
0.291CysPhe: 0.291 ± 0.149
0.801CysGly: 0.801 ± 0.315
0.218CysHis: 0.218 ± 0.143
0.218CysIle: 0.218 ± 0.123
0.146CysLys: 0.146 ± 0.089
0.437CysLeu: 0.437 ± 0.162
0.0CysMet: 0.0 ± 0.0
0.218CysAsn: 0.218 ± 0.143
0.291CysPro: 0.291 ± 0.155
0.146CysGln: 0.146 ± 0.112
0.655CysArg: 0.655 ± 0.2
0.364CysSer: 0.364 ± 0.173
0.583CysThr: 0.583 ± 0.182
0.146CysVal: 0.146 ± 0.137
0.291CysTrp: 0.291 ± 0.138
0.146CysTyr: 0.146 ± 0.106
0.0CysXaa: 0.0 ± 0.0
Asp
9.758AspAla: 9.758 ± 0.755
0.291AspCys: 0.291 ± 0.112
5.971AspAsp: 5.971 ± 0.914
5.024AspGlu: 5.024 ± 0.575
1.748AspPhe: 1.748 ± 0.317
8.083AspGly: 8.083 ± 0.776
1.456AspHis: 1.456 ± 0.281
2.403AspIle: 2.403 ± 0.492
1.675AspLys: 1.675 ± 0.54
5.971AspLeu: 5.971 ± 0.698
1.456AspMet: 1.456 ± 0.254
1.384AspAsn: 1.384 ± 0.277
4.223AspPro: 4.223 ± 0.657
2.84AspGln: 2.84 ± 0.368
4.296AspArg: 4.296 ± 0.671
2.549AspSer: 2.549 ± 0.421
4.005AspThr: 4.005 ± 0.718
4.369AspVal: 4.369 ± 0.615
1.748AspTrp: 1.748 ± 0.298
1.238AspTyr: 1.238 ± 0.309
0.0AspXaa: 0.0 ± 0.0
Glu
5.971GluAla: 5.971 ± 0.515
0.364GluCys: 0.364 ± 0.153
2.767GluAsp: 2.767 ± 0.388
4.442GluGlu: 4.442 ± 0.977
1.529GluPhe: 1.529 ± 0.316
3.131GluGly: 3.131 ± 0.452
2.039GluHis: 2.039 ± 0.411
3.932GluIle: 3.932 ± 0.619
2.84GluLys: 2.84 ± 0.485
5.388GluLeu: 5.388 ± 0.801
1.602GluMet: 1.602 ± 0.297
1.529GluAsn: 1.529 ± 0.283
4.515GluPro: 4.515 ± 0.706
3.277GluGln: 3.277 ± 0.367
4.66GluArg: 4.66 ± 0.662
3.714GluSer: 3.714 ± 0.386
3.422GluThr: 3.422 ± 0.466
4.296GluVal: 4.296 ± 0.532
1.384GluTrp: 1.384 ± 0.299
2.33GluTyr: 2.33 ± 0.442
0.0GluXaa: 0.0 ± 0.0
Phe
2.33PheAla: 2.33 ± 0.407
0.291PheCys: 0.291 ± 0.12
2.476PheAsp: 2.476 ± 0.339
1.675PheGlu: 1.675 ± 0.325
1.019PhePhe: 1.019 ± 0.417
2.986PheGly: 2.986 ± 0.469
0.51PheHis: 0.51 ± 0.202
1.384PheIle: 1.384 ± 0.241
1.019PheLys: 1.019 ± 0.229
2.185PheLeu: 2.185 ± 0.472
0.583PheMet: 0.583 ± 0.164
0.51PheAsn: 0.51 ± 0.205
0.801PhePro: 0.801 ± 0.284
0.728PheGln: 0.728 ± 0.182
1.748PheArg: 1.748 ± 0.368
1.384PheSer: 1.384 ± 0.438
1.602PheThr: 1.602 ± 0.258
1.456PheVal: 1.456 ± 0.292
0.583PheTrp: 0.583 ± 0.192
0.364PheTyr: 0.364 ± 0.116
0.0PheXaa: 0.0 ± 0.0
Gly
8.957GlyAla: 8.957 ± 1.109
0.51GlyCys: 0.51 ± 0.208
5.607GlyAsp: 5.607 ± 0.602
5.024GlyGlu: 5.024 ± 0.6
2.403GlyPhe: 2.403 ± 0.362
7.719GlyGly: 7.719 ± 1.135
2.767GlyHis: 2.767 ± 0.475
3.859GlyIle: 3.859 ± 0.849
4.369GlyLys: 4.369 ± 0.614
6.335GlyLeu: 6.335 ± 0.587
3.277GlyMet: 3.277 ± 0.53
1.893GlyAsn: 1.893 ± 0.296
4.078GlyPro: 4.078 ± 0.516
2.767GlyGln: 2.767 ± 0.337
6.626GlyArg: 6.626 ± 0.589
3.786GlySer: 3.786 ± 0.733
5.534GlyThr: 5.534 ± 0.686
6.335GlyVal: 6.335 ± 0.84
2.112GlyTrp: 2.112 ± 0.306
2.403GlyTyr: 2.403 ± 0.41
0.0GlyXaa: 0.0 ± 0.0
His
2.403HisAla: 2.403 ± 0.474
0.291HisCys: 0.291 ± 0.17
1.675HisAsp: 1.675 ± 0.361
1.456HisGlu: 1.456 ± 0.343
0.291HisPhe: 0.291 ± 0.149
1.893HisGly: 1.893 ± 0.45
0.655HisHis: 0.655 ± 0.293
1.238HisIle: 1.238 ± 0.245
0.51HisLys: 0.51 ± 0.197
2.33HisLeu: 2.33 ± 0.431
0.291HisMet: 0.291 ± 0.137
0.291HisAsn: 0.291 ± 0.147
1.456HisPro: 1.456 ± 0.302
1.238HisGln: 1.238 ± 0.306
1.238HisArg: 1.238 ± 0.312
0.728HisSer: 0.728 ± 0.176
1.092HisThr: 1.092 ± 0.249
2.549HisVal: 2.549 ± 0.497
0.291HisTrp: 0.291 ± 0.14
0.655HisTyr: 0.655 ± 0.21
0.0HisXaa: 0.0 ± 0.0
Ile
6.554IleAla: 6.554 ± 0.688
0.218IleCys: 0.218 ± 0.129
4.587IleAsp: 4.587 ± 0.652
2.84IleGlu: 2.84 ± 0.397
1.019IlePhe: 1.019 ± 0.286
4.005IleGly: 4.005 ± 0.886
1.092IleHis: 1.092 ± 0.309
2.84IleIle: 2.84 ± 0.385
1.092IleLys: 1.092 ± 0.305
2.694IleLeu: 2.694 ± 0.393
0.728IleMet: 0.728 ± 0.225
1.092IleAsn: 1.092 ± 0.307
2.694IlePro: 2.694 ± 0.485
1.456IleGln: 1.456 ± 0.316
3.204IleArg: 3.204 ± 0.502
2.403IleSer: 2.403 ± 0.502
3.859IleThr: 3.859 ± 0.591
3.277IleVal: 3.277 ± 0.456
0.437IleTrp: 0.437 ± 0.199
0.947IleTyr: 0.947 ± 0.343
0.0IleXaa: 0.0 ± 0.0
Lys
4.806LysAla: 4.806 ± 0.99
0.0LysCys: 0.0 ± 0.0
1.529LysAsp: 1.529 ± 0.37
1.384LysGlu: 1.384 ± 0.335
0.801LysPhe: 0.801 ± 0.239
2.112LysGly: 2.112 ± 0.305
0.801LysHis: 0.801 ± 0.233
1.311LysIle: 1.311 ± 0.283
1.165LysLys: 1.165 ± 0.361
3.422LysLeu: 3.422 ± 0.494
0.728LysMet: 0.728 ± 0.261
0.437LysAsn: 0.437 ± 0.143
1.893LysPro: 1.893 ± 0.376
1.675LysGln: 1.675 ± 0.4
2.549LysArg: 2.549 ± 0.502
2.33LysSer: 2.33 ± 0.468
2.549LysThr: 2.549 ± 0.48
1.529LysVal: 1.529 ± 0.32
1.019LysTrp: 1.019 ± 0.213
1.019LysTyr: 1.019 ± 0.181
0.0LysXaa: 0.0 ± 0.0
Leu
10.413LeuAla: 10.413 ± 0.963
0.437LeuCys: 0.437 ± 0.185
6.845LeuAsp: 6.845 ± 0.919
3.495LeuGlu: 3.495 ± 0.603
1.966LeuPhe: 1.966 ± 0.44
7.355LeuGly: 7.355 ± 0.827
1.966LeuHis: 1.966 ± 0.419
3.786LeuIle: 3.786 ± 0.552
2.33LeuLys: 2.33 ± 0.509
4.952LeuLeu: 4.952 ± 0.681
1.748LeuMet: 1.748 ± 0.307
2.039LeuAsn: 2.039 ± 0.334
5.825LeuPro: 5.825 ± 0.826
2.257LeuGln: 2.257 ± 0.358
6.481LeuArg: 6.481 ± 0.767
3.932LeuSer: 3.932 ± 0.596
4.879LeuThr: 4.879 ± 0.636
4.733LeuVal: 4.733 ± 0.61
1.82LeuTrp: 1.82 ± 0.336
1.675LeuTyr: 1.675 ± 0.397
0.0LeuXaa: 0.0 ± 0.0
Met
2.913MetAla: 2.913 ± 0.426
0.218MetCys: 0.218 ± 0.124
1.602MetAsp: 1.602 ± 0.298
1.82MetGlu: 1.82 ± 0.468
0.291MetPhe: 0.291 ± 0.126
2.767MetGly: 2.767 ± 0.557
0.291MetHis: 0.291 ± 0.153
0.728MetIle: 0.728 ± 0.272
1.092MetLys: 1.092 ± 0.26
1.529MetLeu: 1.529 ± 0.372
0.146MetMet: 0.146 ± 0.109
0.801MetAsn: 0.801 ± 0.233
1.82MetPro: 1.82 ± 0.295
0.655MetGln: 0.655 ± 0.194
1.384MetArg: 1.384 ± 0.337
1.529MetSer: 1.529 ± 0.313
3.422MetThr: 3.422 ± 0.775
1.238MetVal: 1.238 ± 0.359
0.583MetTrp: 0.583 ± 0.286
0.291MetTyr: 0.291 ± 0.137
0.0MetXaa: 0.0 ± 0.0
Asn
3.204AsnAla: 3.204 ± 0.492
0.073AsnCys: 0.073 ± 0.083
1.238AsnAsp: 1.238 ± 0.275
0.801AsnGlu: 0.801 ± 0.235
0.801AsnPhe: 0.801 ± 0.216
2.84AsnGly: 2.84 ± 0.526
0.728AsnHis: 0.728 ± 0.31
1.019AsnIle: 1.019 ± 0.243
0.437AsnLys: 0.437 ± 0.17
2.767AsnLeu: 2.767 ± 0.467
0.364AsnMet: 0.364 ± 0.136
0.655AsnAsn: 0.655 ± 0.216
2.039AsnPro: 2.039 ± 0.333
0.728AsnGln: 0.728 ± 0.261
1.82AsnArg: 1.82 ± 0.312
0.874AsnSer: 0.874 ± 0.231
1.384AsnThr: 1.384 ± 0.361
1.311AsnVal: 1.311 ± 0.366
0.073AsnTrp: 0.073 ± 0.069
0.437AsnTyr: 0.437 ± 0.198
0.0AsnXaa: 0.0 ± 0.0
Pro
7.355ProAla: 7.355 ± 0.612
0.146ProCys: 0.146 ± 0.092
5.461ProAsp: 5.461 ± 0.75
4.369ProGlu: 4.369 ± 0.655
1.675ProPhe: 1.675 ± 0.236
4.733ProGly: 4.733 ± 0.752
1.019ProHis: 1.019 ± 0.29
2.33ProIle: 2.33 ± 0.407
2.257ProLys: 2.257 ± 0.568
3.058ProLeu: 3.058 ± 0.393
1.748ProMet: 1.748 ± 0.444
1.238ProAsn: 1.238 ± 0.26
3.786ProPro: 3.786 ± 0.846
1.456ProGln: 1.456 ± 0.356
3.932ProArg: 3.932 ± 0.597
2.185ProSer: 2.185 ± 0.477
3.932ProThr: 3.932 ± 0.62
4.515ProVal: 4.515 ± 0.503
1.384ProTrp: 1.384 ± 0.327
0.947ProTyr: 0.947 ± 0.237
0.0ProXaa: 0.0 ± 0.0
Gln
5.024GlnAla: 5.024 ± 0.782
0.291GlnCys: 0.291 ± 0.137
0.947GlnAsp: 0.947 ± 0.317
1.82GlnGlu: 1.82 ± 0.315
1.019GlnPhe: 1.019 ± 0.319
2.694GlnGly: 2.694 ± 0.429
0.655GlnHis: 0.655 ± 0.223
1.748GlnIle: 1.748 ± 0.386
1.384GlnLys: 1.384 ± 0.342
4.151GlnLeu: 4.151 ± 0.48
0.874GlnMet: 0.874 ± 0.249
0.728GlnAsn: 0.728 ± 0.275
1.384GlnPro: 1.384 ± 0.309
1.602GlnGln: 1.602 ± 0.322
2.621GlnArg: 2.621 ± 0.357
1.238GlnSer: 1.238 ± 0.29
1.748GlnThr: 1.748 ± 0.33
3.277GlnVal: 3.277 ± 0.443
1.238GlnTrp: 1.238 ± 0.264
0.583GlnTyr: 0.583 ± 0.218
0.0GlnXaa: 0.0 ± 0.0
Arg
8.447ArgAla: 8.447 ± 0.847
0.874ArgCys: 0.874 ± 0.312
5.753ArgAsp: 5.753 ± 0.756
4.369ArgGlu: 4.369 ± 0.656
2.185ArgPhe: 2.185 ± 0.328
4.223ArgGly: 4.223 ± 0.525
1.529ArgHis: 1.529 ± 0.39
3.641ArgIle: 3.641 ± 0.517
2.767ArgLys: 2.767 ± 0.379
5.607ArgLeu: 5.607 ± 0.803
2.549ArgMet: 2.549 ± 0.385
1.966ArgAsn: 1.966 ± 0.45
3.786ArgPro: 3.786 ± 0.681
2.403ArgGln: 2.403 ± 0.452
6.189ArgArg: 6.189 ± 0.748
3.568ArgSer: 3.568 ± 0.606
3.714ArgThr: 3.714 ± 0.415
4.587ArgVal: 4.587 ± 0.598
2.185ArgTrp: 2.185 ± 0.445
1.456ArgTyr: 1.456 ± 0.406
0.0ArgXaa: 0.0 ± 0.0
Ser
5.68SerAla: 5.68 ± 0.728
0.218SerCys: 0.218 ± 0.146
2.694SerAsp: 2.694 ± 0.471
2.549SerGlu: 2.549 ± 0.507
1.602SerPhe: 1.602 ± 0.345
4.952SerGly: 4.952 ± 1.122
1.529SerHis: 1.529 ± 0.383
2.112SerIle: 2.112 ± 0.379
1.092SerLys: 1.092 ± 0.284
3.35SerLeu: 3.35 ± 0.607
1.238SerMet: 1.238 ± 0.264
1.165SerAsn: 1.165 ± 0.28
1.893SerPro: 1.893 ± 0.391
1.748SerGln: 1.748 ± 0.289
3.422SerArg: 3.422 ± 0.475
2.476SerSer: 2.476 ± 0.474
4.296SerThr: 4.296 ± 0.663
3.568SerVal: 3.568 ± 0.591
1.092SerTrp: 1.092 ± 0.225
0.801SerTyr: 0.801 ± 0.232
0.0SerXaa: 0.0 ± 0.0
Thr
8.083ThrAla: 8.083 ± 0.79
0.291ThrCys: 0.291 ± 0.19
4.005ThrAsp: 4.005 ± 0.696
3.422ThrGlu: 3.422 ± 0.506
1.311ThrPhe: 1.311 ± 0.266
5.898ThrGly: 5.898 ± 0.563
1.092ThrHis: 1.092 ± 0.241
3.568ThrIle: 3.568 ± 0.828
1.82ThrLys: 1.82 ± 0.286
5.68ThrLeu: 5.68 ± 0.696
1.384ThrMet: 1.384 ± 0.329
1.82ThrAsn: 1.82 ± 0.381
4.296ThrPro: 4.296 ± 0.769
1.748ThrGln: 1.748 ± 0.376
4.151ThrArg: 4.151 ± 0.646
3.131ThrSer: 3.131 ± 0.847
4.952ThrThr: 4.952 ± 0.808
5.17ThrVal: 5.17 ± 0.866
1.238ThrTrp: 1.238 ± 0.293
1.675ThrTyr: 1.675 ± 0.342
0.0ThrXaa: 0.0 ± 0.0
Val
10.122ValAla: 10.122 ± 0.957
0.364ValCys: 0.364 ± 0.161
4.442ValAsp: 4.442 ± 0.558
5.388ValGlu: 5.388 ± 0.652
1.602ValPhe: 1.602 ± 0.385
6.335ValGly: 6.335 ± 0.73
1.675ValHis: 1.675 ± 0.34
2.767ValIle: 2.767 ± 0.497
2.112ValLys: 2.112 ± 0.424
4.806ValLeu: 4.806 ± 0.643
1.092ValMet: 1.092 ± 0.283
2.039ValAsn: 2.039 ± 0.395
2.913ValPro: 2.913 ± 0.428
1.893ValGln: 1.893 ± 0.443
4.879ValArg: 4.879 ± 0.599
3.568ValSer: 3.568 ± 0.448
4.66ValThr: 4.66 ± 0.659
4.587ValVal: 4.587 ± 0.646
1.529ValTrp: 1.529 ± 0.318
1.238ValTyr: 1.238 ± 0.305
0.0ValXaa: 0.0 ± 0.0
Trp
3.058TrpAla: 3.058 ± 0.555
0.364TrpCys: 0.364 ± 0.159
1.456TrpAsp: 1.456 ± 0.336
1.82TrpGlu: 1.82 ± 0.352
0.655TrpPhe: 0.655 ± 0.224
1.456TrpGly: 1.456 ± 0.311
0.291TrpHis: 0.291 ± 0.159
1.311TrpIle: 1.311 ± 0.283
0.364TrpLys: 0.364 ± 0.13
1.966TrpLeu: 1.966 ± 0.452
0.655TrpMet: 0.655 ± 0.223
0.801TrpAsn: 0.801 ± 0.239
1.311TrpPro: 1.311 ± 0.299
0.655TrpGln: 0.655 ± 0.173
2.257TrpArg: 2.257 ± 0.353
0.947TrpSer: 0.947 ± 0.244
1.311TrpThr: 1.311 ± 0.404
1.165TrpVal: 1.165 ± 0.312
0.51TrpTrp: 0.51 ± 0.164
0.218TrpTyr: 0.218 ± 0.167
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.131TyrAla: 3.131 ± 0.429
0.218TyrCys: 0.218 ± 0.15
1.384TyrAsp: 1.384 ± 0.321
1.384TyrGlu: 1.384 ± 0.271
0.51TyrPhe: 0.51 ± 0.204
1.384TyrGly: 1.384 ± 0.35
0.51TyrHis: 0.51 ± 0.21
0.874TyrIle: 0.874 ± 0.244
0.51TyrLys: 0.51 ± 0.198
1.456TyrLeu: 1.456 ± 0.361
0.364TyrMet: 0.364 ± 0.153
0.583TyrAsn: 0.583 ± 0.205
1.165TyrPro: 1.165 ± 0.366
0.728TyrGln: 0.728 ± 0.217
2.33TyrArg: 2.33 ± 0.409
1.384TyrSer: 1.384 ± 0.384
1.238TyrThr: 1.238 ± 0.287
1.602TyrVal: 1.602 ± 0.303
0.437TyrTrp: 0.437 ± 0.198
0.291TyrTyr: 0.291 ± 0.211
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 57 proteins (13734 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski