Amino acid dipepetide frequency for Mycobacterium virus Pukovnik

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.9AlaAla: 11.9 ± 1.189
0.429AlaCys: 0.429 ± 0.176
6.686AlaAsp: 6.686 ± 0.641
6.87AlaGlu: 6.87 ± 0.764
3.619AlaPhe: 3.619 ± 0.497
7.606AlaGly: 7.606 ± 0.859
1.595AlaHis: 1.595 ± 0.298
4.723AlaIle: 4.723 ± 0.493
6.073AlaLys: 6.073 ± 0.722
8.158AlaLeu: 8.158 ± 0.742
3.067AlaMet: 3.067 ± 0.452
3.128AlaAsn: 3.128 ± 0.528
5.275AlaPro: 5.275 ± 0.686
3.619AlaGln: 3.619 ± 0.546
6.686AlaArg: 6.686 ± 0.717
4.048AlaSer: 4.048 ± 0.546
4.662AlaThr: 4.662 ± 0.503
7.238AlaVal: 7.238 ± 0.643
1.84AlaTrp: 1.84 ± 0.395
2.454AlaTyr: 2.454 ± 0.446
0.0AlaXaa: 0.0 ± 0.0
Cys
0.675CysAla: 0.675 ± 0.215
0.0CysCys: 0.0 ± 0.0
0.429CysAsp: 0.429 ± 0.139
0.552CysGlu: 0.552 ± 0.181
0.491CysPhe: 0.491 ± 0.183
0.859CysGly: 0.859 ± 0.245
0.245CysHis: 0.245 ± 0.124
0.061CysIle: 0.061 ± 0.057
0.429CysLys: 0.429 ± 0.147
0.368CysLeu: 0.368 ± 0.165
0.245CysMet: 0.245 ± 0.154
0.491CysAsn: 0.491 ± 0.143
0.613CysPro: 0.613 ± 0.259
0.368CysGln: 0.368 ± 0.167
0.429CysArg: 0.429 ± 0.194
0.429CysSer: 0.429 ± 0.195
0.859CysThr: 0.859 ± 0.227
0.613CysVal: 0.613 ± 0.175
0.552CysTrp: 0.552 ± 0.206
0.307CysTyr: 0.307 ± 0.134
0.0CysXaa: 0.0 ± 0.0
Asp
5.827AspAla: 5.827 ± 0.702
0.613AspCys: 0.613 ± 0.2
3.312AspAsp: 3.312 ± 0.533
4.048AspGlu: 4.048 ± 0.553
2.944AspPhe: 2.944 ± 0.495
5.827AspGly: 5.827 ± 0.653
1.472AspHis: 1.472 ± 0.312
3.312AspIle: 3.312 ± 0.401
2.392AspLys: 2.392 ± 0.38
5.336AspLeu: 5.336 ± 0.572
1.165AspMet: 1.165 ± 0.223
1.717AspAsn: 1.717 ± 0.361
4.784AspPro: 4.784 ± 0.653
1.717AspGln: 1.717 ± 0.391
2.822AspArg: 2.822 ± 0.338
3.435AspSer: 3.435 ± 0.409
4.048AspThr: 4.048 ± 0.582
4.171AspVal: 4.171 ± 0.504
1.288AspTrp: 1.288 ± 0.243
1.963AspTyr: 1.963 ± 0.324
0.0AspXaa: 0.0 ± 0.0
Glu
7.483GluAla: 7.483 ± 0.831
0.245GluCys: 0.245 ± 0.137
4.539GluAsp: 4.539 ± 0.595
4.478GluGlu: 4.478 ± 0.67
2.576GluPhe: 2.576 ± 0.422
5.704GluGly: 5.704 ± 0.591
2.024GluHis: 2.024 ± 0.31
3.619GluIle: 3.619 ± 0.422
2.147GluLys: 2.147 ± 0.419
6.563GluLeu: 6.563 ± 0.769
2.392GluMet: 2.392 ± 0.388
1.84GluAsn: 1.84 ± 0.322
2.822GluPro: 2.822 ± 0.394
2.086GluGln: 2.086 ± 0.317
4.662GluArg: 4.662 ± 0.591
2.27GluSer: 2.27 ± 0.351
3.128GluThr: 3.128 ± 0.386
4.478GluVal: 4.478 ± 0.462
1.411GluTrp: 1.411 ± 0.295
1.779GluTyr: 1.779 ± 0.314
0.0GluXaa: 0.0 ± 0.0
Phe
3.864PheAla: 3.864 ± 0.46
0.613PheCys: 0.613 ± 0.176
2.392PheAsp: 2.392 ± 0.448
3.067PheGlu: 3.067 ± 0.485
0.859PhePhe: 0.859 ± 0.256
3.251PheGly: 3.251 ± 0.598
0.675PheHis: 0.675 ± 0.224
0.981PheIle: 0.981 ± 0.279
1.227PheLys: 1.227 ± 0.266
2.208PheLeu: 2.208 ± 0.392
0.429PheMet: 0.429 ± 0.14
1.779PheAsn: 1.779 ± 0.385
1.779PhePro: 1.779 ± 0.301
1.104PheGln: 1.104 ± 0.281
2.392PheArg: 2.392 ± 0.334
1.84PheSer: 1.84 ± 0.306
2.392PheThr: 2.392 ± 0.476
2.822PheVal: 2.822 ± 0.407
0.429PheTrp: 0.429 ± 0.158
0.859PheTyr: 0.859 ± 0.201
0.0PheXaa: 0.0 ± 0.0
Gly
6.502GlyAla: 6.502 ± 0.645
0.797GlyCys: 0.797 ± 0.216
6.502GlyAsp: 6.502 ± 1.13
4.907GlyGlu: 4.907 ± 0.621
3.128GlyPhe: 3.128 ± 0.499
8.158GlyGly: 8.158 ± 1.157
2.086GlyHis: 2.086 ± 0.411
4.539GlyIle: 4.539 ± 0.743
4.171GlyLys: 4.171 ± 0.523
7.054GlyLeu: 7.054 ± 0.721
2.392GlyMet: 2.392 ± 0.454
3.19GlyAsn: 3.19 ± 0.446
4.784GlyPro: 4.784 ± 1.906
3.742GlyGln: 3.742 ± 0.465
4.355GlyArg: 4.355 ± 0.481
5.03GlySer: 5.03 ± 0.945
5.214GlyThr: 5.214 ± 0.711
6.073GlyVal: 6.073 ± 0.596
2.086GlyTrp: 2.086 ± 0.293
2.515GlyTyr: 2.515 ± 0.372
0.0GlyXaa: 0.0 ± 0.0
His
2.208HisAla: 2.208 ± 0.416
0.245HisCys: 0.245 ± 0.109
1.349HisAsp: 1.349 ± 0.304
1.288HisGlu: 1.288 ± 0.216
0.675HisPhe: 0.675 ± 0.171
1.963HisGly: 1.963 ± 0.484
0.491HisHis: 0.491 ± 0.181
1.104HisIle: 1.104 ± 0.317
0.859HisLys: 0.859 ± 0.249
1.533HisLeu: 1.533 ± 0.321
0.368HisMet: 0.368 ± 0.141
0.307HisAsn: 0.307 ± 0.128
1.104HisPro: 1.104 ± 0.253
1.104HisGln: 1.104 ± 0.235
1.717HisArg: 1.717 ± 0.403
1.043HisSer: 1.043 ± 0.318
1.227HisThr: 1.227 ± 0.254
1.349HisVal: 1.349 ± 0.301
0.368HisTrp: 0.368 ± 0.16
0.552HisTyr: 0.552 ± 0.23
0.0HisXaa: 0.0 ± 0.0
Ile
4.968IleAla: 4.968 ± 0.586
0.491IleCys: 0.491 ± 0.188
3.803IleAsp: 3.803 ± 0.371
4.784IleGlu: 4.784 ± 0.502
1.411IlePhe: 1.411 ± 0.305
4.294IleGly: 4.294 ± 0.609
1.043IleHis: 1.043 ± 0.247
2.208IleIle: 2.208 ± 0.392
2.454IleLys: 2.454 ± 0.46
4.048IleLeu: 4.048 ± 0.437
0.491IleMet: 0.491 ± 0.186
2.024IleAsn: 2.024 ± 0.383
3.435IlePro: 3.435 ± 0.477
1.656IleGln: 1.656 ± 0.362
3.619IleArg: 3.619 ± 0.493
2.024IleSer: 2.024 ± 0.329
2.822IleThr: 2.822 ± 0.367
3.374IleVal: 3.374 ± 0.369
0.736IleTrp: 0.736 ± 0.212
0.92IleTyr: 0.92 ± 0.227
0.0IleXaa: 0.0 ± 0.0
Lys
5.459LysAla: 5.459 ± 0.541
0.245LysCys: 0.245 ± 0.129
2.515LysAsp: 2.515 ± 0.452
2.515LysGlu: 2.515 ± 0.601
1.104LysPhe: 1.104 ± 0.228
4.294LysGly: 4.294 ± 0.867
0.859LysHis: 0.859 ± 0.228
2.944LysIle: 2.944 ± 0.576
3.128LysLys: 3.128 ± 0.487
3.864LysLeu: 3.864 ± 0.47
0.797LysMet: 0.797 ± 0.223
1.779LysAsn: 1.779 ± 0.317
3.128LysPro: 3.128 ± 0.506
1.717LysGln: 1.717 ± 0.374
3.496LysArg: 3.496 ± 0.569
3.006LysSer: 3.006 ± 0.477
2.822LysThr: 2.822 ± 0.463
3.435LysVal: 3.435 ± 0.497
0.92LysTrp: 0.92 ± 0.199
1.043LysTyr: 1.043 ± 0.216
0.0LysXaa: 0.0 ± 0.0
Leu
7.851LeuAla: 7.851 ± 0.672
0.675LeuCys: 0.675 ± 0.235
4.846LeuAsp: 4.846 ± 0.466
4.846LeuGlu: 4.846 ± 0.598
2.331LeuPhe: 2.331 ± 0.293
5.766LeuGly: 5.766 ± 0.604
1.779LeuHis: 1.779 ± 0.313
4.784LeuIle: 4.784 ± 0.522
4.11LeuLys: 4.11 ± 0.7
4.539LeuLeu: 4.539 ± 0.549
2.638LeuMet: 2.638 ± 0.367
2.331LeuAsn: 2.331 ± 0.431
4.232LeuPro: 4.232 ± 0.473
2.208LeuGln: 2.208 ± 0.4
6.073LeuArg: 6.073 ± 0.59
5.95LeuSer: 5.95 ± 0.659
5.152LeuThr: 5.152 ± 0.589
4.171LeuVal: 4.171 ± 0.58
1.349LeuTrp: 1.349 ± 0.276
2.638LeuTyr: 2.638 ± 0.437
0.0LeuXaa: 0.0 ± 0.0
Met
3.251MetAla: 3.251 ± 0.558
0.061MetCys: 0.061 ± 0.057
1.165MetAsp: 1.165 ± 0.258
1.227MetGlu: 1.227 ± 0.241
0.675MetPhe: 0.675 ± 0.186
1.901MetGly: 1.901 ± 0.337
0.613MetHis: 0.613 ± 0.146
1.411MetIle: 1.411 ± 0.361
1.411MetLys: 1.411 ± 0.291
1.533MetLeu: 1.533 ± 0.311
0.736MetMet: 0.736 ± 0.222
0.797MetAsn: 0.797 ± 0.253
1.104MetPro: 1.104 ± 0.22
0.736MetGln: 0.736 ± 0.21
1.288MetArg: 1.288 ± 0.279
2.454MetSer: 2.454 ± 0.342
1.84MetThr: 1.84 ± 0.378
1.779MetVal: 1.779 ± 0.368
0.368MetTrp: 0.368 ± 0.119
0.859MetTyr: 0.859 ± 0.237
0.0MetXaa: 0.0 ± 0.0
Asn
2.883AsnAla: 2.883 ± 0.54
0.429AsnCys: 0.429 ± 0.168
1.533AsnAsp: 1.533 ± 0.342
2.208AsnGlu: 2.208 ± 0.401
0.981AsnPhe: 0.981 ± 0.263
3.435AsnGly: 3.435 ± 0.46
0.797AsnHis: 0.797 ± 0.2
1.227AsnIle: 1.227 ± 0.27
1.165AsnLys: 1.165 ± 0.268
2.944AsnLeu: 2.944 ± 0.447
0.92AsnMet: 0.92 ± 0.22
0.859AsnAsn: 0.859 ± 0.217
2.454AsnPro: 2.454 ± 0.312
0.797AsnGln: 0.797 ± 0.204
2.024AsnArg: 2.024 ± 0.427
1.349AsnSer: 1.349 ± 0.336
1.901AsnThr: 1.901 ± 0.306
3.006AsnVal: 3.006 ± 0.418
0.613AsnTrp: 0.613 ± 0.168
1.043AsnTyr: 1.043 ± 0.201
0.0AsnXaa: 0.0 ± 0.0
Pro
4.907ProAla: 4.907 ± 0.564
0.307ProCys: 0.307 ± 0.163
4.11ProAsp: 4.11 ± 0.541
4.539ProGlu: 4.539 ± 0.495
2.331ProPhe: 2.331 ± 0.332
5.152ProGly: 5.152 ± 0.723
0.92ProHis: 0.92 ± 0.209
2.822ProIle: 2.822 ± 0.408
2.822ProLys: 2.822 ± 0.556
2.883ProLeu: 2.883 ± 0.412
1.043ProMet: 1.043 ± 0.277
1.84ProAsn: 1.84 ± 0.463
2.576ProPro: 2.576 ± 0.508
2.331ProGln: 2.331 ± 0.822
3.864ProArg: 3.864 ± 0.578
2.883ProSer: 2.883 ± 0.498
3.803ProThr: 3.803 ± 0.435
3.251ProVal: 3.251 ± 0.439
1.165ProTrp: 1.165 ± 0.414
1.411ProTyr: 1.411 ± 0.314
0.0ProXaa: 0.0 ± 0.0
Gln
4.662GlnAla: 4.662 ± 0.466
0.307GlnCys: 0.307 ± 0.148
1.227GlnAsp: 1.227 ± 0.241
2.576GlnGlu: 2.576 ± 0.372
1.411GlnPhe: 1.411 ± 0.255
3.864GlnGly: 3.864 ± 1.442
0.613GlnHis: 0.613 ± 0.185
2.392GlnIle: 2.392 ± 0.363
1.717GlnLys: 1.717 ± 0.358
3.19GlnLeu: 3.19 ± 0.611
1.104GlnMet: 1.104 ± 0.228
1.043GlnAsn: 1.043 ± 0.248
1.043GlnPro: 1.043 ± 0.357
1.472GlnGln: 1.472 ± 0.335
2.699GlnArg: 2.699 ± 0.351
1.288GlnSer: 1.288 ± 0.336
1.901GlnThr: 1.901 ± 0.339
2.392GlnVal: 2.392 ± 0.32
0.736GlnTrp: 0.736 ± 0.212
0.613GlnTyr: 0.613 ± 0.167
0.0GlnXaa: 0.0 ± 0.0
Arg
6.073ArgAla: 6.073 ± 0.707
0.736ArgCys: 0.736 ± 0.253
3.19ArgAsp: 3.19 ± 0.445
4.723ArgGlu: 4.723 ± 0.6
2.392ArgPhe: 2.392 ± 0.465
4.662ArgGly: 4.662 ± 0.637
1.779ArgHis: 1.779 ± 0.374
3.558ArgIle: 3.558 ± 0.447
4.232ArgLys: 4.232 ± 0.567
5.766ArgLeu: 5.766 ± 0.579
2.331ArgMet: 2.331 ± 0.373
1.901ArgAsn: 1.901 ± 0.319
2.454ArgPro: 2.454 ± 0.416
2.147ArgGln: 2.147 ± 0.413
5.582ArgArg: 5.582 ± 0.763
3.006ArgSer: 3.006 ± 0.435
2.883ArgThr: 2.883 ± 0.48
4.294ArgVal: 4.294 ± 0.447
1.227ArgTrp: 1.227 ± 0.298
2.27ArgTyr: 2.27 ± 0.406
0.0ArgXaa: 0.0 ± 0.0
Ser
4.171SerAla: 4.171 ± 0.491
0.429SerCys: 0.429 ± 0.168
3.312SerAsp: 3.312 ± 0.522
3.128SerGlu: 3.128 ± 0.433
1.963SerPhe: 1.963 ± 0.413
4.846SerGly: 4.846 ± 0.732
0.613SerHis: 0.613 ± 0.181
2.392SerIle: 2.392 ± 0.477
2.27SerLys: 2.27 ± 0.389
4.232SerLeu: 4.232 ± 0.544
1.411SerMet: 1.411 ± 0.297
1.227SerAsn: 1.227 ± 0.241
2.944SerPro: 2.944 ± 0.394
2.331SerGln: 2.331 ± 0.398
3.312SerArg: 3.312 ± 0.494
2.454SerSer: 2.454 ± 0.526
3.251SerThr: 3.251 ± 0.365
4.232SerVal: 4.232 ± 0.517
1.349SerTrp: 1.349 ± 0.302
1.717SerTyr: 1.717 ± 0.308
0.0SerXaa: 0.0 ± 0.0
Thr
5.643ThrAla: 5.643 ± 0.584
0.92ThrCys: 0.92 ± 0.268
3.374ThrAsp: 3.374 ± 0.433
3.128ThrGlu: 3.128 ± 0.389
2.454ThrPhe: 2.454 ± 0.446
6.318ThrGly: 6.318 ± 0.967
1.349ThrHis: 1.349 ± 0.301
2.576ThrIle: 2.576 ± 0.468
2.883ThrLys: 2.883 ± 0.421
4.907ThrLeu: 4.907 ± 0.481
1.411ThrMet: 1.411 ± 0.236
1.349ThrAsn: 1.349 ± 0.296
4.355ThrPro: 4.355 ± 0.481
2.638ThrGln: 2.638 ± 0.46
2.208ThrArg: 2.208 ± 0.393
2.699ThrSer: 2.699 ± 0.451
3.68ThrThr: 3.68 ± 0.535
4.171ThrVal: 4.171 ± 0.515
1.227ThrTrp: 1.227 ± 0.303
1.717ThrTyr: 1.717 ± 0.319
0.0ThrXaa: 0.0 ± 0.0
Val
6.563ValAla: 6.563 ± 0.753
0.797ValCys: 0.797 ± 0.21
4.907ValAsp: 4.907 ± 0.461
4.355ValGlu: 4.355 ± 0.511
2.27ValPhe: 2.27 ± 0.405
5.52ValGly: 5.52 ± 0.658
0.981ValHis: 0.981 ± 0.253
3.251ValIle: 3.251 ± 0.501
3.803ValLys: 3.803 ± 0.508
5.336ValLeu: 5.336 ± 0.66
1.349ValMet: 1.349 ± 0.284
3.251ValAsn: 3.251 ± 0.515
3.68ValPro: 3.68 ± 0.518
2.147ValGln: 2.147 ± 0.292
4.11ValArg: 4.11 ± 0.558
4.294ValSer: 4.294 ± 0.599
4.355ValThr: 4.355 ± 0.472
5.459ValVal: 5.459 ± 0.633
1.472ValTrp: 1.472 ± 0.322
1.533ValTyr: 1.533 ± 0.357
0.0ValXaa: 0.0 ± 0.0
Trp
1.779TrpAla: 1.779 ± 0.379
0.491TrpCys: 0.491 ± 0.151
1.165TrpAsp: 1.165 ± 0.257
1.288TrpGlu: 1.288 ± 0.281
0.491TrpPhe: 0.491 ± 0.197
1.411TrpGly: 1.411 ± 0.311
0.429TrpHis: 0.429 ± 0.18
1.043TrpIle: 1.043 ± 0.255
0.736TrpLys: 0.736 ± 0.205
1.472TrpLeu: 1.472 ± 0.271
0.491TrpMet: 0.491 ± 0.154
1.043TrpAsn: 1.043 ± 0.352
0.981TrpPro: 0.981 ± 0.276
1.165TrpGln: 1.165 ± 0.247
1.349TrpArg: 1.349 ± 0.273
0.797TrpSer: 0.797 ± 0.219
1.717TrpThr: 1.717 ± 0.303
1.288TrpVal: 1.288 ± 0.231
0.552TrpTrp: 0.552 ± 0.179
0.491TrpTyr: 0.491 ± 0.159
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.006TyrAla: 3.006 ± 0.419
0.184TyrCys: 0.184 ± 0.113
1.84TyrAsp: 1.84 ± 0.327
1.717TyrGlu: 1.717 ± 0.357
0.859TyrPhe: 0.859 ± 0.187
2.392TyrGly: 2.392 ± 0.405
0.491TyrHis: 0.491 ± 0.187
1.656TyrIle: 1.656 ± 0.311
1.043TyrLys: 1.043 ± 0.229
2.331TyrLeu: 2.331 ± 0.362
0.368TyrMet: 0.368 ± 0.193
0.675TyrAsn: 0.675 ± 0.219
1.411TyrPro: 1.411 ± 0.33
1.165TyrGln: 1.165 ± 0.254
2.515TyrArg: 2.515 ± 0.405
1.349TyrSer: 1.349 ± 0.325
1.349TyrThr: 1.349 ± 0.247
1.84TyrVal: 1.84 ± 0.351
0.491TyrTrp: 0.491 ± 0.172
0.797TyrTyr: 0.797 ± 0.218
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 88 proteins (16304 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski