Amino acid dipepetide frequency for Dorea sp. 5-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.441AlaAla: 7.441 ± 0.106
1.171AlaCys: 1.171 ± 0.028
4.658AlaAsp: 4.658 ± 0.06
5.802AlaGlu: 5.802 ± 0.081
2.918AlaPhe: 2.918 ± 0.039
6.204AlaGly: 6.204 ± 0.079
1.074AlaHis: 1.074 ± 0.026
4.509AlaIle: 4.509 ± 0.058
4.626AlaLys: 4.626 ± 0.052
6.64AlaLeu: 6.64 ± 0.068
2.311AlaMet: 2.311 ± 0.037
2.408AlaAsn: 2.408 ± 0.042
1.942AlaPro: 1.942 ± 0.042
2.259AlaGln: 2.259 ± 0.038
3.34AlaArg: 3.34 ± 0.042
3.817AlaSer: 3.817 ± 0.057
2.639AlaThr: 2.639 ± 0.048
6.437AlaVal: 6.437 ± 0.063
0.646AlaTrp: 0.646 ± 0.02
2.883AlaTyr: 2.883 ± 0.042
0.0AlaXaa: 0.0 ± 0.0
Cys
1.005CysAla: 1.005 ± 0.027
0.305CysCys: 0.305 ± 0.015
0.825CysAsp: 0.825 ± 0.027
0.989CysGlu: 0.989 ± 0.027
0.715CysPhe: 0.715 ± 0.022
1.536CysGly: 1.536 ± 0.031
0.355CysHis: 0.355 ± 0.014
1.146CysIle: 1.146 ± 0.028
0.905CysLys: 0.905 ± 0.023
1.255CysLeu: 1.255 ± 0.028
0.496CysMet: 0.496 ± 0.016
0.584CysAsn: 0.584 ± 0.019
0.675CysPro: 0.675 ± 0.02
0.481CysGln: 0.481 ± 0.016
0.974CysArg: 0.974 ± 0.024
0.923CysSer: 0.923 ± 0.023
0.767CysThr: 0.767 ± 0.023
0.99CysVal: 0.99 ± 0.025
0.136CysTrp: 0.136 ± 0.009
0.622CysTyr: 0.622 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
3.99AspAla: 3.99 ± 0.055
0.829AspCys: 0.829 ± 0.023
2.807AspAsp: 2.807 ± 0.051
4.683AspGlu: 4.683 ± 0.055
2.572AspPhe: 2.572 ± 0.036
4.537AspGly: 4.537 ± 0.075
0.994AspHis: 0.994 ± 0.026
4.505AspIle: 4.505 ± 0.054
3.412AspLys: 3.412 ± 0.046
4.461AspLeu: 4.461 ± 0.05
1.946AspMet: 1.946 ± 0.038
2.052AspAsn: 2.052 ± 0.041
1.851AspPro: 1.851 ± 0.031
1.404AspGln: 1.404 ± 0.035
2.813AspArg: 2.813 ± 0.046
3.011AspSer: 3.011 ± 0.042
3.21AspThr: 3.21 ± 0.044
3.764AspVal: 3.764 ± 0.051
0.619AspTrp: 0.619 ± 0.021
2.795AspTyr: 2.795 ± 0.043
0.0AspXaa: 0.0 ± 0.0
Glu
5.832GluAla: 5.832 ± 0.072
0.978GluCys: 0.978 ± 0.025
4.645GluAsp: 4.645 ± 0.057
7.949GluGlu: 7.949 ± 0.103
2.705GluPhe: 2.705 ± 0.044
4.77GluGly: 4.77 ± 0.06
1.441GluHis: 1.441 ± 0.028
5.887GluIle: 5.887 ± 0.06
6.73GluLys: 6.73 ± 0.072
7.116GluLeu: 7.116 ± 0.075
2.625GluMet: 2.625 ± 0.042
4.003GluAsn: 4.003 ± 0.051
2.013GluPro: 2.013 ± 0.042
3.29GluGln: 3.29 ± 0.055
4.105GluArg: 4.105 ± 0.061
3.574GluSer: 3.574 ± 0.054
3.714GluThr: 3.714 ± 0.062
4.542GluVal: 4.542 ± 0.053
0.817GluTrp: 0.817 ± 0.021
3.596GluTyr: 3.596 ± 0.047
0.0GluXaa: 0.0 ± 0.0
Phe
2.896PheAla: 2.896 ± 0.042
0.846PheCys: 0.846 ± 0.023
2.447PheAsp: 2.447 ± 0.041
2.683PheGlu: 2.683 ± 0.035
1.813PhePhe: 1.813 ± 0.041
2.869PheGly: 2.869 ± 0.046
0.894PheHis: 0.894 ± 0.022
2.782PheIle: 2.782 ± 0.044
1.855PheLys: 1.855 ± 0.032
4.084PheLeu: 4.084 ± 0.064
1.127PheMet: 1.127 ± 0.027
1.367PheAsn: 1.367 ± 0.031
1.405PhePro: 1.405 ± 0.029
1.372PheGln: 1.372 ± 0.03
2.059PheArg: 2.059 ± 0.037
2.835PheSer: 2.835 ± 0.043
2.171PheThr: 2.171 ± 0.036
2.657PheVal: 2.657 ± 0.043
0.412PheTrp: 0.412 ± 0.015
1.772PheTyr: 1.772 ± 0.037
0.0PheXaa: 0.0 ± 0.0
Gly
4.857GlyAla: 4.857 ± 0.068
1.266GlyCys: 1.266 ± 0.028
3.394GlyAsp: 3.394 ± 0.051
5.028GlyGlu: 5.028 ± 0.062
3.041GlyPhe: 3.041 ± 0.047
4.782GlyGly: 4.782 ± 0.076
1.242GlyHis: 1.242 ± 0.03
6.249GlyIle: 6.249 ± 0.067
5.605GlyLys: 5.605 ± 0.057
5.55GlyLeu: 5.55 ± 0.061
2.612GlyMet: 2.612 ± 0.038
3.171GlyAsn: 3.171 ± 0.046
1.007GlyPro: 1.007 ± 0.025
2.22GlyGln: 2.22 ± 0.047
3.697GlyArg: 3.697 ± 0.061
4.041GlySer: 4.041 ± 0.068
4.095GlyThr: 4.095 ± 0.059
4.595GlyVal: 4.595 ± 0.065
0.758GlyTrp: 0.758 ± 0.035
3.507GlyTyr: 3.507 ± 0.04
0.0GlyXaa: 0.0 ± 0.0
His
1.179HisAla: 1.179 ± 0.029
0.302HisCys: 0.302 ± 0.013
0.932HisAsp: 0.932 ± 0.023
1.177HisGlu: 1.177 ± 0.027
0.832HisPhe: 0.832 ± 0.021
1.293HisGly: 1.293 ± 0.031
0.384HisHis: 0.384 ± 0.016
1.481HisIle: 1.481 ± 0.038
1.039HisLys: 1.039 ± 0.027
1.572HisLeu: 1.572 ± 0.031
0.654HisMet: 0.654 ± 0.019
0.702HisAsn: 0.702 ± 0.02
0.856HisPro: 0.856 ± 0.022
0.567HisGln: 0.567 ± 0.02
0.889HisArg: 0.889 ± 0.021
1.077HisSer: 1.077 ± 0.026
1.007HisThr: 1.007 ± 0.024
1.125HisVal: 1.125 ± 0.027
0.165HisTrp: 0.165 ± 0.009
0.81HisTyr: 0.81 ± 0.02
0.0HisXaa: 0.0 ± 0.0
Ile
5.454IleAla: 5.454 ± 0.058
1.372IleCys: 1.372 ± 0.029
3.949IleAsp: 3.949 ± 0.052
5.099IleGlu: 5.099 ± 0.063
2.887IlePhe: 2.887 ± 0.05
4.955IleGly: 4.955 ± 0.065
1.421IleHis: 1.421 ± 0.032
4.742IleIle: 4.742 ± 0.054
3.778IleLys: 3.778 ± 0.049
7.163IleLeu: 7.163 ± 0.092
2.012IleMet: 2.012 ± 0.037
2.639IleAsn: 2.639 ± 0.042
3.11IlePro: 3.11 ± 0.044
2.306IleGln: 2.306 ± 0.035
4.266IleArg: 4.266 ± 0.054
4.793IleSer: 4.793 ± 0.063
3.911IleThr: 3.911 ± 0.048
4.593IleVal: 4.593 ± 0.066
0.675IleTrp: 0.675 ± 0.022
2.862IleTyr: 2.862 ± 0.044
0.0IleXaa: 0.0 ± 0.0
Lys
4.854LysAla: 4.854 ± 0.058
0.735LysCys: 0.735 ± 0.023
3.909LysAsp: 3.909 ± 0.054
7.145LysGlu: 7.145 ± 0.077
1.728LysPhe: 1.728 ± 0.032
4.221LysGly: 4.221 ± 0.048
1.035LysHis: 1.035 ± 0.025
4.737LysIle: 4.737 ± 0.063
5.961LysLys: 5.961 ± 0.064
5.158LysLeu: 5.158 ± 0.056
2.097LysMet: 2.097 ± 0.033
3.373LysAsn: 3.373 ± 0.052
2.041LysPro: 2.041 ± 0.037
2.356LysGln: 2.356 ± 0.039
3.588LysArg: 3.588 ± 0.056
3.301LysSer: 3.301 ± 0.048
3.488LysThr: 3.488 ± 0.047
3.983LysVal: 3.983 ± 0.044
0.641LysTrp: 0.641 ± 0.021
2.933LysTyr: 2.933 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
6.694LeuAla: 6.694 ± 0.07
1.637LeuCys: 1.637 ± 0.033
5.054LeuAsp: 5.054 ± 0.051
6.528LeuGlu: 6.528 ± 0.069
3.851LeuPhe: 3.851 ± 0.066
5.694LeuGly: 5.694 ± 0.072
1.653LeuHis: 1.653 ± 0.036
5.782LeuIle: 5.782 ± 0.069
6.165LeuLys: 6.165 ± 0.067
8.782LeuLeu: 8.782 ± 0.112
2.573LeuMet: 2.573 ± 0.042
3.658LeuAsn: 3.658 ± 0.048
3.642LeuPro: 3.642 ± 0.051
2.789LeuGln: 2.789 ± 0.042
4.361LeuArg: 4.361 ± 0.057
6.304LeuSer: 6.304 ± 0.072
4.914LeuThr: 4.914 ± 0.051
5.135LeuVal: 5.135 ± 0.056
0.798LeuTrp: 0.798 ± 0.024
3.569LeuTyr: 3.569 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
2.352MetAla: 2.352 ± 0.042
0.387MetCys: 0.387 ± 0.017
2.007MetAsp: 2.007 ± 0.038
2.812MetGlu: 2.812 ± 0.044
1.02MetPhe: 1.02 ± 0.025
2.092MetGly: 2.092 ± 0.038
0.492MetHis: 0.492 ± 0.019
2.176MetIle: 2.176 ± 0.043
2.604MetLys: 2.604 ± 0.045
2.84MetLeu: 2.84 ± 0.045
0.939MetMet: 0.939 ± 0.026
1.539MetAsn: 1.539 ± 0.034
1.162MetPro: 1.162 ± 0.03
1.16MetGln: 1.16 ± 0.026
1.455MetArg: 1.455 ± 0.028
1.846MetSer: 1.846 ± 0.032
1.631MetThr: 1.631 ± 0.034
1.87MetVal: 1.87 ± 0.036
0.244MetTrp: 0.244 ± 0.013
1.007MetTyr: 1.007 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.985AsnAla: 2.985 ± 0.039
0.62AsnCys: 0.62 ± 0.019
2.038AsnAsp: 2.038 ± 0.032
2.761AsnGlu: 2.761 ± 0.044
1.495AsnPhe: 1.495 ± 0.032
3.286AsnGly: 3.286 ± 0.05
0.852AsnHis: 0.852 ± 0.028
3.268AsnIle: 3.268 ± 0.052
2.246AsnLys: 2.246 ± 0.041
3.749AsnLeu: 3.749 ± 0.047
1.322AsnMet: 1.322 ± 0.032
1.6AsnAsn: 1.6 ± 0.032
1.847AsnPro: 1.847 ± 0.038
1.439AsnGln: 1.439 ± 0.036
2.232AsnArg: 2.232 ± 0.04
2.195AsnSer: 2.195 ± 0.035
2.173AsnThr: 2.173 ± 0.04
2.628AsnVal: 2.628 ± 0.042
0.397AsnTrp: 0.397 ± 0.016
1.764AsnTyr: 1.764 ± 0.035
0.0AsnXaa: 0.0 ± 0.0
Pro
2.48ProAla: 2.48 ± 0.045
0.465ProCys: 0.465 ± 0.017
2.369ProAsp: 2.369 ± 0.037
3.432ProGlu: 3.432 ± 0.047
1.484ProPhe: 1.484 ± 0.03
2.321ProGly: 2.321 ± 0.039
0.571ProHis: 0.571 ± 0.018
1.912ProIle: 1.912 ± 0.036
1.906ProLys: 1.906 ± 0.036
2.645ProLeu: 2.645 ± 0.043
0.872ProMet: 0.872 ± 0.024
1.12ProAsn: 1.12 ± 0.027
0.828ProPro: 0.828 ± 0.025
1.067ProGln: 1.067 ± 0.024
1.123ProArg: 1.123 ± 0.028
1.758ProSer: 1.758 ± 0.032
1.39ProThr: 1.39 ± 0.03
2.935ProVal: 2.935 ± 0.042
0.317ProTrp: 0.317 ± 0.013
1.503ProTyr: 1.503 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.562GlnAla: 2.562 ± 0.04
0.398GlnCys: 0.398 ± 0.015
1.645GlnAsp: 1.645 ± 0.034
3.09GlnGlu: 3.09 ± 0.053
1.208GlnPhe: 1.208 ± 0.025
2.03GlnGly: 2.03 ± 0.039
0.458GlnHis: 0.458 ± 0.015
2.718GlnIle: 2.718 ± 0.036
2.856GlnLys: 2.856 ± 0.049
2.764GlnLeu: 2.764 ± 0.044
1.216GlnMet: 1.216 ± 0.031
1.569GlnAsn: 1.569 ± 0.032
0.942GlnPro: 0.942 ± 0.026
1.214GlnGln: 1.214 ± 0.033
1.727GlnArg: 1.727 ± 0.036
1.695GlnSer: 1.695 ± 0.037
1.643GlnThr: 1.643 ± 0.034
1.962GlnVal: 1.962 ± 0.033
0.342GlnTrp: 0.342 ± 0.014
1.445GlnTyr: 1.445 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
2.978ArgAla: 2.978 ± 0.04
0.706ArgCys: 0.706 ± 0.022
2.503ArgAsp: 2.503 ± 0.042
4.554ArgGlu: 4.554 ± 0.059
2.126ArgPhe: 2.126 ± 0.04
2.819ArgGly: 2.819 ± 0.041
1.015ArgHis: 1.015 ± 0.023
4.057ArgIle: 4.057 ± 0.058
4.088ArgLys: 4.088 ± 0.06
4.659ArgLeu: 4.659 ± 0.053
1.914ArgMet: 1.914 ± 0.033
2.345ArgAsn: 2.345 ± 0.039
1.303ArgPro: 1.303 ± 0.03
2.22ArgGln: 2.22 ± 0.037
3.144ArgArg: 3.144 ± 0.06
2.553ArgSer: 2.553 ± 0.042
2.398ArgThr: 2.398 ± 0.04
2.791ArgVal: 2.791 ± 0.043
0.492ArgTrp: 0.492 ± 0.017
2.383ArgTyr: 2.383 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
4.153SerAla: 4.153 ± 0.056
0.844SerCys: 0.844 ± 0.02
3.256SerAsp: 3.256 ± 0.048
4.089SerGlu: 4.089 ± 0.056
2.626SerPhe: 2.626 ± 0.044
5.102SerGly: 5.102 ± 0.068
1.078SerHis: 1.078 ± 0.025
3.992SerIle: 3.992 ± 0.055
3.314SerLys: 3.314 ± 0.046
5.164SerLeu: 5.164 ± 0.065
1.867SerMet: 1.867 ± 0.034
2.01SerAsn: 2.01 ± 0.039
1.763SerPro: 1.763 ± 0.032
1.833SerGln: 1.833 ± 0.036
2.948SerArg: 2.948 ± 0.045
3.257SerSer: 3.257 ± 0.052
2.444SerThr: 2.444 ± 0.053
4.349SerVal: 4.349 ± 0.059
0.563SerTrp: 0.563 ± 0.018
2.458SerTyr: 2.458 ± 0.044
0.0SerXaa: 0.0 ± 0.0
Thr
4.461ThrAla: 4.461 ± 0.056
0.662ThrCys: 0.662 ± 0.019
3.182ThrAsp: 3.182 ± 0.045
3.98ThrGlu: 3.98 ± 0.055
2.021ThrPhe: 2.021 ± 0.038
4.395ThrGly: 4.395 ± 0.056
0.841ThrHis: 0.841 ± 0.023
3.4ThrIle: 3.4 ± 0.043
2.815ThrLys: 2.815 ± 0.048
4.508ThrLeu: 4.508 ± 0.05
1.386ThrMet: 1.386 ± 0.029
1.782ThrAsn: 1.782 ± 0.036
2.028ThrPro: 2.028 ± 0.036
1.409ThrGln: 1.409 ± 0.027
2.028ThrArg: 2.028 ± 0.036
2.644ThrSer: 2.644 ± 0.05
2.403ThrThr: 2.403 ± 0.046
4.12ThrVal: 4.12 ± 0.055
0.5ThrTrp: 0.5 ± 0.019
1.944ThrTyr: 1.944 ± 0.032
0.0ThrXaa: 0.0 ± 0.0
Val
4.156ValAla: 4.156 ± 0.055
1.265ValCys: 1.265 ± 0.031
3.525ValAsp: 3.525 ± 0.047
4.481ValGlu: 4.481 ± 0.059
3.029ValPhe: 3.029 ± 0.049
3.97ValGly: 3.97 ± 0.057
1.1ValHis: 1.1 ± 0.027
4.945ValIle: 4.945 ± 0.066
4.337ValLys: 4.337 ± 0.054
6.409ValLeu: 6.409 ± 0.079
2.139ValMet: 2.139 ± 0.04
2.659ValAsn: 2.659 ± 0.039
2.387ValPro: 2.387 ± 0.045
2.013ValGln: 2.013 ± 0.036
3.426ValArg: 3.426 ± 0.052
4.708ValSer: 4.708 ± 0.059
3.781ValThr: 3.781 ± 0.051
4.298ValVal: 4.298 ± 0.056
0.707ValTrp: 0.707 ± 0.018
2.7ValTyr: 2.7 ± 0.039
0.0ValXaa: 0.0 ± 0.0
Trp
0.542TrpAla: 0.542 ± 0.019
0.175TrpCys: 0.175 ± 0.01
0.591TrpAsp: 0.591 ± 0.021
0.788TrpGlu: 0.788 ± 0.024
0.395TrpPhe: 0.395 ± 0.015
0.716TrpGly: 0.716 ± 0.023
0.198TrpHis: 0.198 ± 0.011
0.73TrpIle: 0.73 ± 0.023
0.754TrpLys: 0.754 ± 0.024
0.922TrpLeu: 0.922 ± 0.022
0.331TrpMet: 0.331 ± 0.014
0.581TrpAsn: 0.581 ± 0.022
0.165TrpPro: 0.165 ± 0.01
0.405TrpGln: 0.405 ± 0.016
0.452TrpArg: 0.452 ± 0.017
0.455TrpSer: 0.455 ± 0.019
0.446TrpThr: 0.446 ± 0.018
0.551TrpVal: 0.551 ± 0.018
0.116TrpTrp: 0.116 ± 0.009
0.455TrpTyr: 0.455 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.855TyrAla: 2.855 ± 0.043
0.723TyrCys: 0.723 ± 0.021
2.518TyrAsp: 2.518 ± 0.05
3.261TyrGlu: 3.261 ± 0.048
1.88TyrPhe: 1.88 ± 0.035
3.123TyrGly: 3.123 ± 0.038
0.945TyrHis: 0.945 ± 0.021
2.967TyrIle: 2.967 ± 0.046
2.289TyrLys: 2.289 ± 0.043
4.143TyrLeu: 4.143 ± 0.051
1.197TyrMet: 1.197 ± 0.027
1.735TyrAsn: 1.735 ± 0.034
1.53TyrPro: 1.53 ± 0.03
1.681TyrGln: 1.681 ± 0.029
2.418TyrArg: 2.418 ± 0.045
2.319TyrSer: 2.319 ± 0.042
2.284TyrThr: 2.284 ± 0.037
2.711TyrVal: 2.711 ± 0.041
0.426TyrTrp: 0.426 ± 0.017
2.05TyrTyr: 2.05 ± 0.042
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5824 proteins (1704686 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski