Amino acid dipepetide frequency for Cognatishimia maritima

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	14.248AlaAla: 14.248 ± 0.16	1.067AlaCys: 1.067 ± 0.031	6.586AlaAsp: 6.586 ± 0.103	8.107AlaGlu: 8.107 ± 0.102	4.235AlaPhe: 4.235 ± 0.07	9.166AlaGly: 9.166 ± 0.099	2.191AlaHis: 2.191 ± 0.042	6.03AlaIle: 6.03 ± 0.086	4.882AlaLys: 4.882 ± 0.089	12.696AlaLeu: 12.696 ± 0.14	3.681AlaMet: 3.681 ± 0.064	3.06AlaAsn: 3.06 ± 0.054	5.064AlaPro: 5.064 ± 0.079	4.531AlaGln: 4.531 ± 0.08	6.937AlaArg: 6.937 ± 0.101	5.476AlaSer: 5.476 ± 0.078	5.755AlaThr: 5.755 ± 0.08	7.693AlaVal: 7.693 ± 0.1	1.267AlaTrp: 1.267 ± 0.043	2.585AlaTyr: 2.585 ± 0.052	0.0AlaXaa: 0.0 ± 0.0
Cys	1.058CysAla: 1.058 ± 0.034	0.11CysCys: 0.11 ± 0.012	0.66CysAsp: 0.66 ± 0.027	0.501CysGlu: 0.501 ± 0.026	0.361CysPhe: 0.361 ± 0.018	0.937CysGly: 0.937 ± 0.032	0.272CysHis: 0.272 ± 0.017	0.46CysIle: 0.46 ± 0.023	0.268CysLys: 0.268 ± 0.017	0.874CysLeu: 0.874 ± 0.027	0.201CysMet: 0.201 ± 0.013	0.231CysAsn: 0.231 ± 0.015	0.493CysPro: 0.493 ± 0.024	0.302CysGln: 0.302 ± 0.019	0.54CysArg: 0.54 ± 0.024	0.485CysSer: 0.485 ± 0.026	0.469CysThr: 0.469 ± 0.023	0.628CysVal: 0.628 ± 0.023	0.113CysTrp: 0.113 ± 0.011	0.228CysTyr: 0.228 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	6.974AspAla: 6.974 ± 0.099	0.575AspCys: 0.575 ± 0.024	3.484AspAsp: 3.484 ± 0.072	3.639AspGlu: 3.639 ± 0.071	2.552AspPhe: 2.552 ± 0.051	5.168AspGly: 5.168 ± 0.089	1.423AspHis: 1.423 ± 0.042	3.61AspIle: 3.61 ± 0.048	2.045AspLys: 2.045 ± 0.052	6.66AspLeu: 6.66 ± 0.089	1.785AspMet: 1.785 ± 0.042	1.437AspAsn: 1.437 ± 0.037	3.256AspPro: 3.256 ± 0.058	2.189AspGln: 2.189 ± 0.045	3.877AspArg: 3.877 ± 0.077	2.378AspSer: 2.378 ± 0.052	2.905AspThr: 2.905 ± 0.062	4.552AspVal: 4.552 ± 0.078	1.085AspTrp: 1.085 ± 0.035	1.657AspTyr: 1.657 ± 0.042	0.0AspXaa: 0.0 ± 0.0
Glu	7.931GluAla: 7.931 ± 0.103	0.429GluCys: 0.429 ± 0.022	3.712GluAsp: 3.712 ± 0.068	3.796GluGlu: 3.796 ± 0.08	2.111GluPhe: 2.111 ± 0.035	4.75GluGly: 4.75 ± 0.083	1.192GluHis: 1.192 ± 0.041	3.948GluIle: 3.948 ± 0.07	2.705GluLys: 2.705 ± 0.056	5.313GluLeu: 5.313 ± 0.081	1.956GluMet: 1.956 ± 0.045	2.206GluAsn: 2.206 ± 0.048	2.312GluPro: 2.312 ± 0.054	2.043GluGln: 2.043 ± 0.047	3.936GluArg: 3.936 ± 0.068	2.59GluSer: 2.59 ± 0.044	3.959GluThr: 3.959 ± 0.067	4.483GluVal: 4.483 ± 0.079	0.738GluTrp: 0.738 ± 0.024	1.118GluTyr: 1.118 ± 0.035	0.0GluXaa: 0.0 ± 0.0
Phe	4.566PheAla: 4.566 ± 0.069	0.466PheCys: 0.466 ± 0.021	3.021PheAsp: 3.021 ± 0.056	2.469PheGlu: 2.469 ± 0.054	1.666PhePhe: 1.666 ± 0.049	3.824PheGly: 3.824 ± 0.057	0.771PheHis: 0.771 ± 0.032	1.836PheIle: 1.836 ± 0.054	1.248PheLys: 1.248 ± 0.039	3.645PheLeu: 3.645 ± 0.075	0.977PheMet: 0.977 ± 0.032	1.142PheAsn: 1.142 ± 0.035	1.598PhePro: 1.598 ± 0.042	1.265PheGln: 1.265 ± 0.037	2.011PheArg: 2.011 ± 0.044	2.266PheSer: 2.266 ± 0.051	2.095PheThr: 2.095 ± 0.048	2.923PheVal: 2.923 ± 0.058	0.607PheTrp: 0.607 ± 0.025	1.003PheTyr: 1.003 ± 0.032	0.0PheXaa: 0.0 ± 0.0
Gly	8.724GlyAla: 8.724 ± 0.1	0.868GlyCys: 0.868 ± 0.034	4.639GlyAsp: 4.639 ± 0.085	4.646GlyGlu: 4.646 ± 0.072	3.791GlyPhe: 3.791 ± 0.071	6.659GlyGly: 6.659 ± 0.118	1.867GlyHis: 1.867 ± 0.043	4.545GlyIle: 4.545 ± 0.075	3.597GlyLys: 3.597 ± 0.066	8.489GlyLeu: 8.489 ± 0.107	2.471GlyMet: 2.471 ± 0.06	2.17GlyAsn: 2.17 ± 0.057	3.218GlyPro: 3.218 ± 0.065	3.147GlyGln: 3.147 ± 0.055	4.828GlyArg: 4.828 ± 0.08	4.076GlySer: 4.076 ± 0.065	4.46GlyThr: 4.46 ± 0.066	6.37GlyVal: 6.37 ± 0.078	1.37GlyTrp: 1.37 ± 0.038	2.255GlyTyr: 2.255 ± 0.048	0.0GlyXaa: 0.0 ± 0.0
His	2.148HisAla: 2.148 ± 0.049	0.25HisCys: 0.25 ± 0.019	1.258HisAsp: 1.258 ± 0.039	1.117HisGlu: 1.117 ± 0.034	0.923HisPhe: 0.923 ± 0.032	1.75HisGly: 1.75 ± 0.046	0.579HisHis: 0.579 ± 0.025	1.102HisIle: 1.102 ± 0.034	0.681HisLys: 0.681 ± 0.027	2.161HisLeu: 2.161 ± 0.059	0.596HisMet: 0.596 ± 0.027	0.536HisAsn: 0.536 ± 0.025	1.34HisPro: 1.34 ± 0.044	0.635HisGln: 0.635 ± 0.027	1.293HisArg: 1.293 ± 0.039	0.979HisSer: 0.979 ± 0.034	0.867HisThr: 0.867 ± 0.034	1.593HisVal: 1.593 ± 0.042	0.375HisTrp: 0.375 ± 0.019	0.589HisTyr: 0.589 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.997IleAla: 6.997 ± 0.086	0.656IleCys: 0.656 ± 0.026	3.74IleAsp: 3.74 ± 0.061	3.79IleGlu: 3.79 ± 0.057	2.066IlePhe: 2.066 ± 0.052	4.815IleGly: 4.815 ± 0.069	0.98IleHis: 0.98 ± 0.037	2.5IleIle: 2.5 ± 0.055	1.973IleLys: 1.973 ± 0.043	5.17IleLeu: 5.17 ± 0.083	1.231IleMet: 1.231 ± 0.041	1.62IleAsn: 1.62 ± 0.042	2.445IlePro: 2.445 ± 0.056	1.468IleGln: 1.468 ± 0.039	3.011IleArg: 3.011 ± 0.06	3.444IleSer: 3.444 ± 0.067	2.923IleThr: 2.923 ± 0.065	3.995IleVal: 3.995 ± 0.074	0.767IleTrp: 0.767 ± 0.028	1.28IleTyr: 1.28 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	4.882LysAla: 4.882 ± 0.082	0.216LysCys: 0.216 ± 0.014	2.497LysAsp: 2.497 ± 0.055	2.125LysGlu: 2.125 ± 0.056	1.254LysPhe: 1.254 ± 0.039	3.151LysGly: 3.151 ± 0.062	0.786LysHis: 0.786 ± 0.031	2.194LysIle: 2.194 ± 0.048	1.618LysLys: 1.618 ± 0.047	3.535LysLeu: 3.535 ± 0.065	1.088LysMet: 1.088 ± 0.032	1.115LysAsn: 1.115 ± 0.034	2.077LysPro: 2.077 ± 0.054	1.24LysGln: 1.24 ± 0.033	2.602LysArg: 2.602 ± 0.059	2.325LysSer: 2.325 ± 0.048	2.372LysThr: 2.372 ± 0.051	2.75LysVal: 2.75 ± 0.062	0.493LysTrp: 0.493 ± 0.023	0.785LysTyr: 0.785 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	11.452LeuAla: 11.452 ± 0.133	0.957LeuCys: 0.957 ± 0.033	5.735LeuAsp: 5.735 ± 0.073	5.74LeuGlu: 5.74 ± 0.095	3.637LeuPhe: 3.637 ± 0.072	8.11LeuGly: 8.11 ± 0.102	1.821LeuHis: 1.821 ± 0.045	5.512LeuIle: 5.512 ± 0.094	4.135LeuLys: 4.135 ± 0.07	8.794LeuLeu: 8.794 ± 0.144	2.726LeuMet: 2.726 ± 0.052	3.027LeuAsn: 3.027 ± 0.057	5.251LeuPro: 5.251 ± 0.085	3.165LeuGln: 3.165 ± 0.055	6.455LeuArg: 6.455 ± 0.094	6.614LeuSer: 6.614 ± 0.094	6.0LeuThr: 6.0 ± 0.091	6.681LeuVal: 6.681 ± 0.099	1.326LeuTrp: 1.326 ± 0.037	1.941LeuTyr: 1.941 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.423MetAla: 3.423 ± 0.058	0.21MetCys: 0.21 ± 0.014	1.53MetAsp: 1.53 ± 0.043	1.425MetGlu: 1.425 ± 0.041	0.875MetPhe: 0.875 ± 0.031	2.284MetGly: 2.284 ± 0.045	0.539MetHis: 0.539 ± 0.024	1.558MetIle: 1.558 ± 0.044	1.227MetLys: 1.227 ± 0.036	2.656MetLeu: 2.656 ± 0.053	0.779MetMet: 0.779 ± 0.033	0.91MetAsn: 0.91 ± 0.031	1.543MetPro: 1.543 ± 0.035	1.116MetGln: 1.116 ± 0.029	1.805MetArg: 1.805 ± 0.047	1.91MetSer: 1.91 ± 0.045	2.07MetThr: 2.07 ± 0.043	1.933MetVal: 1.933 ± 0.047	0.245MetTrp: 0.245 ± 0.015	0.391MetTyr: 0.391 ± 0.019	0.0MetXaa: 0.0 ± 0.0
Asn	3.438AsnAla: 3.438 ± 0.064	0.278AsnCys: 0.278 ± 0.017	1.68AsnAsp: 1.68 ± 0.05	1.441AsnGlu: 1.441 ± 0.04	1.163AsnPhe: 1.163 ± 0.034	2.689AsnGly: 2.689 ± 0.062	0.625AsnHis: 0.625 ± 0.026	1.593AsnIle: 1.593 ± 0.041	0.92AsnLys: 0.92 ± 0.03	2.815AsnLeu: 2.815 ± 0.058	0.793AsnMet: 0.793 ± 0.028	0.824AsnAsn: 0.824 ± 0.029	1.897AsnPro: 1.897 ± 0.048	0.869AsnGln: 0.869 ± 0.031	1.76AsnArg: 1.76 ± 0.037	1.432AsnSer: 1.432 ± 0.034	1.518AsnThr: 1.518 ± 0.04	2.104AsnVal: 2.104 ± 0.046	0.508AsnTrp: 0.508 ± 0.023	0.707AsnTyr: 0.707 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	4.817ProAla: 4.817 ± 0.075	0.362ProCys: 0.362 ± 0.02	3.498ProAsp: 3.498 ± 0.058	4.03ProGlu: 4.03 ± 0.069	1.98ProPhe: 1.98 ± 0.048	3.603ProGly: 3.603 ± 0.063	1.058ProHis: 1.058 ± 0.034	2.447ProIle: 2.447 ± 0.044	2.07ProLys: 2.07 ± 0.05	4.414ProLeu: 4.414 ± 0.071	1.324ProMet: 1.324 ± 0.034	1.588ProAsn: 1.588 ± 0.041	1.78ProPro: 1.78 ± 0.054	1.625ProGln: 1.625 ± 0.039	2.304ProArg: 2.304 ± 0.048	2.524ProSer: 2.524 ± 0.048	2.413ProThr: 2.413 ± 0.049	3.891ProVal: 3.891 ± 0.062	0.627ProTrp: 0.627 ± 0.026	1.179ProTyr: 1.179 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	4.092GlnAla: 4.092 ± 0.066	0.242GlnCys: 0.242 ± 0.015	2.028GlnAsp: 2.028 ± 0.046	1.845GlnGlu: 1.845 ± 0.049	1.266GlnPhe: 1.266 ± 0.036	2.587GlnGly: 2.587 ± 0.051	0.659GlnHis: 0.659 ± 0.025	2.286GlnIle: 2.286 ± 0.052	1.377GlnLys: 1.377 ± 0.035	3.082GlnLeu: 3.082 ± 0.067	1.152GlnMet: 1.152 ± 0.033	1.101GlnAsn: 1.101 ± 0.034	1.621GlnPro: 1.621 ± 0.045	1.229GlnGln: 1.229 ± 0.042	2.216GlnArg: 2.216 ± 0.052	2.131GlnSer: 2.131 ± 0.049	2.0GlnThr: 2.0 ± 0.046	2.426GlnVal: 2.426 ± 0.05	0.411GlnTrp: 0.411 ± 0.021	0.653GlnTyr: 0.653 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	6.78ArgAla: 6.78 ± 0.097	0.432ArgCys: 0.432 ± 0.019	3.786ArgAsp: 3.786 ± 0.062	3.555ArgGlu: 3.555 ± 0.067	2.501ArgPhe: 2.501 ± 0.051	4.005ArgGly: 4.005 ± 0.061	1.382ArgHis: 1.382 ± 0.037	3.436ArgIle: 3.436 ± 0.058	2.612ArgLys: 2.612 ± 0.055	6.55ArgLeu: 6.55 ± 0.102	1.768ArgMet: 1.768 ± 0.041	1.854ArgAsn: 1.854 ± 0.046	2.804ArgPro: 2.804 ± 0.058	2.216ArgGln: 2.216 ± 0.049	4.237ArgArg: 4.237 ± 0.086	3.109ArgSer: 3.109 ± 0.058	2.728ArgThr: 2.728 ± 0.05	4.375ArgVal: 4.375 ± 0.067	0.852ArgTrp: 0.852 ± 0.033	1.508ArgTyr: 1.508 ± 0.039	0.0ArgXaa: 0.0 ± 0.0
Ser	5.76SerAla: 5.76 ± 0.072	0.47SerCys: 0.47 ± 0.023	3.574SerAsp: 3.574 ± 0.068	3.249SerGlu: 3.249 ± 0.062	2.378SerPhe: 2.378 ± 0.055	5.222SerGly: 5.222 ± 0.087	1.162SerHis: 1.162 ± 0.034	2.799SerIle: 2.799 ± 0.057	2.026SerLys: 2.026 ± 0.045	5.179SerLeu: 5.179 ± 0.083	1.448SerMet: 1.448 ± 0.039	1.599SerAsn: 1.599 ± 0.042	2.4SerPro: 2.4 ± 0.048	1.855SerGln: 1.855 ± 0.041	3.148SerArg: 3.148 ± 0.059	2.674SerSer: 2.674 ± 0.058	2.645SerThr: 2.645 ± 0.049	4.005SerVal: 4.005 ± 0.061	0.731SerTrp: 0.731 ± 0.026	1.422SerTyr: 1.422 ± 0.037	0.0SerXaa: 0.0 ± 0.0
Thr	5.835ThrAla: 5.835 ± 0.079	0.527ThrCys: 0.527 ± 0.025	3.159ThrAsp: 3.159 ± 0.062	3.195ThrGlu: 3.195 ± 0.063	2.056ThrPhe: 2.056 ± 0.043	4.924ThrGly: 4.924 ± 0.071	1.198ThrHis: 1.198 ± 0.032	2.868ThrIle: 2.868 ± 0.048	1.869ThrLys: 1.869 ± 0.047	5.886ThrLeu: 5.886 ± 0.078	1.365ThrMet: 1.365 ± 0.041	1.435ThrAsn: 1.435 ± 0.041	3.308ThrPro: 3.308 ± 0.053	1.79ThrGln: 1.79 ± 0.047	3.136ThrArg: 3.136 ± 0.059	2.888ThrSer: 2.888 ± 0.057	2.803ThrThr: 2.803 ± 0.049	4.14ThrVal: 4.14 ± 0.066	0.671ThrTrp: 0.671 ± 0.03	1.359ThrTyr: 1.359 ± 0.04	0.0ThrXaa: 0.0 ± 0.0
Val	8.342ValAla: 8.342 ± 0.09	0.67ValCys: 0.67 ± 0.026	4.277ValAsp: 4.277 ± 0.08	4.408ValGlu: 4.408 ± 0.07	2.98ValPhe: 2.98 ± 0.055	5.462ValGly: 5.462 ± 0.074	1.377ValHis: 1.377 ± 0.04	4.403ValIle: 4.403 ± 0.07	2.623ValLys: 2.623 ± 0.054	7.254ValLeu: 7.254 ± 0.108	2.124ValMet: 2.124 ± 0.056	2.164ValAsn: 2.164 ± 0.058	3.437ValPro: 3.437 ± 0.065	2.306ValGln: 2.306 ± 0.046	3.889ValArg: 3.889 ± 0.066	4.439ValSer: 4.439 ± 0.074	4.617ValThr: 4.617 ± 0.063	5.712ValVal: 5.712 ± 0.089	0.876ValTrp: 0.876 ± 0.033	1.531ValTyr: 1.531 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.285TrpAla: 1.285 ± 0.04	0.127TrpCys: 0.127 ± 0.012	0.777TrpAsp: 0.777 ± 0.03	0.723TrpGlu: 0.723 ± 0.025	0.609TrpPhe: 0.609 ± 0.028	0.985TrpGly: 0.985 ± 0.036	0.339TrpHis: 0.339 ± 0.018	0.742TrpIle: 0.742 ± 0.026	0.508TrpLys: 0.508 ± 0.021	1.557TrpLeu: 1.557 ± 0.044	0.428TrpMet: 0.428 ± 0.024	0.409TrpAsn: 0.409 ± 0.019	0.644TrpPro: 0.644 ± 0.027	0.621TrpGln: 0.621 ± 0.029	0.953TrpArg: 0.953 ± 0.034	0.787TrpSer: 0.787 ± 0.028	0.693TrpThr: 0.693 ± 0.026	0.96TrpVal: 0.96 ± 0.033	0.216TrpTrp: 0.216 ± 0.016	0.27TrpTyr: 0.27 ± 0.018	0.001TrpXaa: 0.001 ± 0.001
Tyr	2.503TyrAla: 2.503 ± 0.05	0.279TyrCys: 0.279 ± 0.015	1.613TyrAsp: 1.613 ± 0.04	1.424TyrGlu: 1.424 ± 0.041	0.995TyrPhe: 0.995 ± 0.032	2.098TyrGly: 2.098 ± 0.05	0.551TyrHis: 0.551 ± 0.022	1.001TyrIle: 1.001 ± 0.029	0.72TyrLys: 0.72 ± 0.027	2.349TyrLeu: 2.349 ± 0.048	0.536TyrMet: 0.536 ± 0.025	0.627TyrAsn: 0.627 ± 0.025	1.045TyrPro: 1.045 ± 0.029	0.794TyrGln: 0.794 ± 0.028	1.55TyrArg: 1.55 ± 0.042	1.22TyrSer: 1.22 ± 0.034	1.121TyrThr: 1.121 ± 0.03	1.678TyrVal: 1.678 ± 0.038	0.358TyrTrp: 0.358 ± 0.019	0.593TyrTyr: 0.593 ± 0.027	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.003XaaXaa: 0.003 ± 0.003

Statistics based on 3233 proteins (981079 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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