Amino acid dipepetide frequency for Carnobacterium maltaromaticum LMA28

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.391AlaAla: 5.391 ± 0.102	0.44AlaCys: 0.44 ± 0.022	3.577AlaAsp: 3.577 ± 0.063	5.0AlaGlu: 5.0 ± 0.082	3.091AlaPhe: 3.091 ± 0.055	5.186AlaGly: 5.186 ± 0.099	1.064AlaHis: 1.064 ± 0.039	5.873AlaIle: 5.873 ± 0.076	5.108AlaLys: 5.108 ± 0.093	7.007AlaLeu: 7.007 ± 0.099	1.861AlaMet: 1.861 ± 0.05	3.304AlaAsn: 3.304 ± 0.066	2.125AlaPro: 2.125 ± 0.056	2.233AlaGln: 2.233 ± 0.056	2.256AlaArg: 2.256 ± 0.053	4.169AlaSer: 4.169 ± 0.073	4.608AlaThr: 4.608 ± 0.081	4.912AlaVal: 4.912 ± 0.076	0.515AlaTrp: 0.515 ± 0.022	2.376AlaTyr: 2.376 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.333CysAla: 0.333 ± 0.019	0.067CysCys: 0.067 ± 0.009	0.275CysAsp: 0.275 ± 0.014	0.363CysGlu: 0.363 ± 0.021	0.308CysPhe: 0.308 ± 0.018	0.583CysGly: 0.583 ± 0.027	0.151CysHis: 0.151 ± 0.013	0.414CysIle: 0.414 ± 0.022	0.22CysLys: 0.22 ± 0.015	0.647CysLeu: 0.647 ± 0.029	0.132CysMet: 0.132 ± 0.011	0.203CysAsn: 0.203 ± 0.014	0.206CysPro: 0.206 ± 0.015	0.277CysGln: 0.277 ± 0.018	0.18CysArg: 0.18 ± 0.014	0.454CysSer: 0.454 ± 0.023	0.324CysThr: 0.324 ± 0.018	0.358CysVal: 0.358 ± 0.019	0.06CysTrp: 0.06 ± 0.008	0.262CysTyr: 0.262 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	3.388AspAla: 3.388 ± 0.062	0.32AspCys: 0.32 ± 0.017	2.379AspAsp: 2.379 ± 0.089	3.969AspGlu: 3.969 ± 0.066	2.769AspPhe: 2.769 ± 0.051	3.51AspGly: 3.51 ± 0.069	0.809AspHis: 0.809 ± 0.037	3.939AspIle: 3.939 ± 0.066	3.43AspLys: 3.43 ± 0.07	5.188AspLeu: 5.188 ± 0.073	1.263AspMet: 1.263 ± 0.037	2.13AspAsn: 2.13 ± 0.049	1.821AspPro: 1.821 ± 0.053	2.01AspGln: 2.01 ± 0.051	1.666AspArg: 1.666 ± 0.039	3.365AspSer: 3.365 ± 0.054	2.804AspThr: 2.804 ± 0.052	3.612AspVal: 3.612 ± 0.062	0.549AspTrp: 0.549 ± 0.022	2.47AspTyr: 2.47 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.611GluAla: 5.611 ± 0.08	0.318GluCys: 0.318 ± 0.016	3.375GluAsp: 3.375 ± 0.071	6.1GluGlu: 6.1 ± 0.106	2.811GluPhe: 2.811 ± 0.05	3.692GluGly: 3.692 ± 0.07	1.186GluHis: 1.186 ± 0.033	5.983GluIle: 5.983 ± 0.088	6.944GluLys: 6.944 ± 0.098	7.701GluLeu: 7.701 ± 0.115	2.2GluMet: 2.2 ± 0.052	4.405GluAsn: 4.405 ± 0.056	1.904GluPro: 1.904 ± 0.039	2.829GluGln: 2.829 ± 0.059	2.814GluArg: 2.814 ± 0.061	3.772GluSer: 3.772 ± 0.07	4.38GluThr: 4.38 ± 0.066	4.975GluVal: 4.975 ± 0.082	0.739GluTrp: 0.739 ± 0.029	2.12GluTyr: 2.12 ± 0.048	0.0GluXaa: 0.0 ± 0.0
Phe	2.792PheAla: 2.792 ± 0.061	0.339PheCys: 0.339 ± 0.019	2.61PheAsp: 2.61 ± 0.057	2.854PheGlu: 2.854 ± 0.055	2.444PhePhe: 2.444 ± 0.059	3.173PheGly: 3.173 ± 0.06	0.73PheHis: 0.73 ± 0.028	4.082PheIle: 4.082 ± 0.082	2.905PheLys: 2.905 ± 0.063	4.426PheLeu: 4.426 ± 0.087	1.129PheMet: 1.129 ± 0.039	2.465PheAsn: 2.465 ± 0.048	1.572PhePro: 1.572 ± 0.04	1.521PheGln: 1.521 ± 0.038	1.267PheArg: 1.267 ± 0.033	3.685PheSer: 3.685 ± 0.069	2.661PheThr: 2.661 ± 0.054	3.03PheVal: 3.03 ± 0.059	0.449PheTrp: 0.449 ± 0.022	1.844PheTyr: 1.844 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	4.708GlyAla: 4.708 ± 0.09	0.448GlyCys: 0.448 ± 0.022	3.143GlyAsp: 3.143 ± 0.067	4.235GlyGlu: 4.235 ± 0.074	3.331GlyPhe: 3.331 ± 0.061	4.502GlyGly: 4.502 ± 0.101	1.072GlyHis: 1.072 ± 0.034	6.125GlyIle: 6.125 ± 0.089	4.72GlyLys: 4.72 ± 0.073	6.426GlyLeu: 6.426 ± 0.1	1.944GlyMet: 1.944 ± 0.053	3.087GlyAsn: 3.087 ± 0.06	1.464GlyPro: 1.464 ± 0.038	2.185GlyGln: 2.185 ± 0.051	2.16GlyArg: 2.16 ± 0.053	4.053GlySer: 4.053 ± 0.088	4.441GlyThr: 4.441 ± 0.085	4.595GlyVal: 4.595 ± 0.081	0.688GlyTrp: 0.688 ± 0.025	2.683GlyTyr: 2.683 ± 0.056	0.0GlyXaa: 0.0 ± 0.0
His	0.905HisAla: 0.905 ± 0.031	0.122HisCys: 0.122 ± 0.011	0.833HisAsp: 0.833 ± 0.032	1.134HisGlu: 1.134 ± 0.035	0.984HisPhe: 0.984 ± 0.033	1.166HisGly: 1.166 ± 0.038	0.439HisHis: 0.439 ± 0.021	1.172HisIle: 1.172 ± 0.037	0.894HisLys: 0.894 ± 0.032	1.795HisLeu: 1.795 ± 0.048	0.391HisMet: 0.391 ± 0.019	0.588HisAsn: 0.588 ± 0.023	0.8HisPro: 0.8 ± 0.031	0.727HisGln: 0.727 ± 0.026	0.627HisArg: 0.627 ± 0.023	1.034HisSer: 1.034 ± 0.031	0.809HisThr: 0.809 ± 0.028	1.033HisVal: 1.033 ± 0.03	0.181HisTrp: 0.181 ± 0.014	0.891HisTyr: 0.891 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.075IleAla: 6.075 ± 0.092	0.634IleCys: 0.634 ± 0.027	4.518IleAsp: 4.518 ± 0.072	6.111IleGlu: 6.111 ± 0.1	3.571IlePhe: 3.571 ± 0.073	5.749IleGly: 5.749 ± 0.092	1.443IleHis: 1.443 ± 0.042	5.836IleIle: 5.836 ± 0.107	5.26IleLys: 5.26 ± 0.079	7.47IleLeu: 7.47 ± 0.111	1.811IleMet: 1.811 ± 0.047	3.663IleAsn: 3.663 ± 0.067	3.385IlePro: 3.385 ± 0.063	3.031IleGln: 3.031 ± 0.049	2.79IleArg: 2.79 ± 0.059	5.496IleSer: 5.496 ± 0.073	4.521IleThr: 4.521 ± 0.075	5.498IleVal: 5.498 ± 0.078	0.597IleTrp: 0.597 ± 0.029	2.546IleTyr: 2.546 ± 0.054	0.0IleXaa: 0.0 ± 0.0
Lys	4.94LysAla: 4.94 ± 0.083	0.234LysCys: 0.234 ± 0.016	3.743LysAsp: 3.743 ± 0.068	7.12LysGlu: 7.12 ± 0.097	2.283LysPhe: 2.283 ± 0.052	4.086LysGly: 4.086 ± 0.061	1.007LysHis: 1.007 ± 0.034	6.017LysIle: 6.017 ± 0.082	7.183LysLys: 7.183 ± 0.102	6.176LysLeu: 6.176 ± 0.085	2.44LysMet: 2.44 ± 0.052	4.509LysAsn: 4.509 ± 0.076	1.954LysPro: 1.954 ± 0.046	2.869LysGln: 2.869 ± 0.056	2.889LysArg: 2.889 ± 0.052	3.737LysSer: 3.737 ± 0.063	4.044LysThr: 4.044 ± 0.062	4.599LysVal: 4.599 ± 0.069	0.706LysTrp: 0.706 ± 0.026	2.279LysTyr: 2.279 ± 0.056	0.0LysXaa: 0.0 ± 0.0
Leu	7.992LeuAla: 7.992 ± 0.091	0.556LeuCys: 0.556 ± 0.024	5.195LeuAsp: 5.195 ± 0.073	6.673LeuGlu: 6.673 ± 0.095	4.813LeuPhe: 4.813 ± 0.096	6.072LeuGly: 6.072 ± 0.103	1.381LeuHis: 1.381 ± 0.038	7.811LeuIle: 7.811 ± 0.106	7.153LeuLys: 7.153 ± 0.083	9.702LeuLeu: 9.702 ± 0.146	2.495LeuMet: 2.495 ± 0.049	4.975LeuAsn: 4.975 ± 0.084	3.698LeuPro: 3.698 ± 0.067	3.07LeuGln: 3.07 ± 0.057	3.019LeuArg: 3.019 ± 0.057	6.804LeuSer: 6.804 ± 0.093	6.625LeuThr: 6.625 ± 0.091	6.931LeuVal: 6.931 ± 0.093	0.713LeuTrp: 0.713 ± 0.028	2.96LeuTyr: 2.96 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	1.908MetAla: 1.908 ± 0.054	0.113MetCys: 0.113 ± 0.01	1.428MetAsp: 1.428 ± 0.037	1.775MetGlu: 1.775 ± 0.043	0.81MetPhe: 0.81 ± 0.028	1.753MetGly: 1.753 ± 0.045	0.38MetHis: 0.38 ± 0.02	2.054MetIle: 2.054 ± 0.054	2.353MetLys: 2.353 ± 0.041	2.33MetLeu: 2.33 ± 0.051	0.784MetMet: 0.784 ± 0.03	1.556MetAsn: 1.556 ± 0.038	0.96MetPro: 0.96 ± 0.029	0.913MetGln: 0.913 ± 0.033	0.905MetArg: 0.905 ± 0.032	1.675MetSer: 1.675 ± 0.041	1.726MetThr: 1.726 ± 0.042	1.657MetVal: 1.657 ± 0.045	0.18MetTrp: 0.18 ± 0.014	0.718MetTyr: 0.718 ± 0.028	0.0MetXaa: 0.0 ± 0.0
Asn	2.859AsnAla: 2.859 ± 0.064	0.294AsnCys: 0.294 ± 0.017	2.384AsnAsp: 2.384 ± 0.052	3.926AsnGlu: 3.926 ± 0.066	2.318AsnPhe: 2.318 ± 0.045	3.707AsnGly: 3.707 ± 0.08	0.97AsnHis: 0.97 ± 0.033	3.187AsnIle: 3.187 ± 0.062	3.456AsnLys: 3.456 ± 0.064	4.717AsnLeu: 4.717 ± 0.071	1.247AsnMet: 1.247 ± 0.035	2.384AsnAsn: 2.384 ± 0.063	2.309AsnPro: 2.309 ± 0.056	3.13AsnGln: 3.13 ± 0.07	1.903AsnArg: 1.903 ± 0.048	3.024AsnSer: 3.024 ± 0.065	2.43AsnThr: 2.43 ± 0.056	2.905AsnVal: 2.905 ± 0.059	0.59AsnTrp: 0.59 ± 0.026	2.204AsnTyr: 2.204 ± 0.049	0.0AsnXaa: 0.0 ± 0.0
Pro	2.244ProAla: 2.244 ± 0.062	0.14ProCys: 0.14 ± 0.013	1.913ProAsp: 1.913 ± 0.044	2.973ProGlu: 2.973 ± 0.076	1.751ProPhe: 1.751 ± 0.042	1.884ProGly: 1.884 ± 0.044	0.558ProHis: 0.558 ± 0.023	2.906ProIle: 2.906 ± 0.055	2.208ProLys: 2.208 ± 0.049	3.289ProLeu: 3.289 ± 0.057	0.789ProMet: 0.789 ± 0.028	1.754ProAsn: 1.754 ± 0.051	0.784ProPro: 0.784 ± 0.028	1.136ProGln: 1.136 ± 0.037	0.872ProArg: 0.872 ± 0.029	1.965ProSer: 1.965 ± 0.041	2.444ProThr: 2.444 ± 0.059	2.775ProVal: 2.775 ± 0.057	0.27ProTrp: 0.27 ± 0.015	1.295ProTyr: 1.295 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	2.856GlnAla: 2.856 ± 0.062	0.138GlnCys: 0.138 ± 0.013	1.69GlnAsp: 1.69 ± 0.043	2.812GlnGlu: 2.812 ± 0.057	1.645GlnPhe: 1.645 ± 0.044	1.944GlnGly: 1.944 ± 0.047	0.607GlnHis: 0.607 ± 0.025	2.863GlnIle: 2.863 ± 0.055	3.097GlnLys: 3.097 ± 0.057	4.585GlnLeu: 4.585 ± 0.079	1.065GlnMet: 1.065 ± 0.037	1.911GlnAsn: 1.911 ± 0.042	1.235GlnPro: 1.235 ± 0.032	1.727GlnGln: 1.727 ± 0.05	1.391GlnArg: 1.391 ± 0.041	2.056GlnSer: 2.056 ± 0.047	2.239GlnThr: 2.239 ± 0.044	2.764GlnVal: 2.764 ± 0.059	0.378GlnTrp: 0.378 ± 0.022	1.127GlnTyr: 1.127 ± 0.038	0.0GlnXaa: 0.0 ± 0.0
Arg	1.914ArgAla: 1.914 ± 0.048	0.199ArgCys: 0.199 ± 0.014	1.614ArgAsp: 1.614 ± 0.041	2.496ArgGlu: 2.496 ± 0.056	1.72ArgPhe: 1.72 ± 0.045	2.062ArgGly: 2.062 ± 0.052	0.638ArgHis: 0.638 ± 0.025	2.801ArgIle: 2.801 ± 0.064	2.655ArgLys: 2.655 ± 0.058	3.542ArgLeu: 3.542 ± 0.068	0.99ArgMet: 0.99 ± 0.034	1.767ArgAsn: 1.767 ± 0.048	1.031ArgPro: 1.031 ± 0.034	1.335ArgGln: 1.335 ± 0.038	1.445ArgArg: 1.445 ± 0.044	1.858ArgSer: 1.858 ± 0.049	1.762ArgThr: 1.762 ± 0.037	2.293ArgVal: 2.293 ± 0.056	0.273ArgTrp: 0.273 ± 0.016	1.54ArgTyr: 1.54 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.82SerAla: 3.82 ± 0.064	0.333SerCys: 0.333 ± 0.018	3.242SerAsp: 3.242 ± 0.057	4.504SerGlu: 4.504 ± 0.065	3.276SerPhe: 3.276 ± 0.07	4.618SerGly: 4.618 ± 0.078	1.094SerHis: 1.094 ± 0.032	5.227SerIle: 5.227 ± 0.077	4.104SerLys: 4.104 ± 0.061	6.472SerLeu: 6.472 ± 0.082	1.431SerMet: 1.431 ± 0.036	3.001SerAsn: 3.001 ± 0.064	1.958SerPro: 1.958 ± 0.049	2.434SerGln: 2.434 ± 0.049	2.036SerArg: 2.036 ± 0.048	4.343SerSer: 4.343 ± 0.098	3.62SerThr: 3.62 ± 0.064	4.129SerVal: 4.129 ± 0.067	0.636SerTrp: 0.636 ± 0.024	2.638SerTyr: 2.638 ± 0.059	0.0SerXaa: 0.0 ± 0.0
Thr	4.236ThrAla: 4.236 ± 0.084	0.306ThrCys: 0.306 ± 0.019	3.316ThrAsp: 3.316 ± 0.063	4.138ThrGlu: 4.138 ± 0.069	2.615ThrPhe: 2.615 ± 0.052	4.545ThrGly: 4.545 ± 0.081	1.014ThrHis: 1.014 ± 0.028	5.471ThrIle: 5.471 ± 0.085	4.227ThrLys: 4.227 ± 0.073	5.684ThrLeu: 5.684 ± 0.088	1.33ThrMet: 1.33 ± 0.038	3.211ThrAsn: 3.211 ± 0.073	2.485ThrPro: 2.485 ± 0.057	1.816ThrGln: 1.816 ± 0.044	1.764ThrArg: 1.764 ± 0.04	3.679ThrSer: 3.679 ± 0.061	3.867ThrThr: 3.867 ± 0.077	4.347ThrVal: 4.347 ± 0.087	0.51ThrTrp: 0.51 ± 0.026	2.1ThrTyr: 2.1 ± 0.053	0.0ThrXaa: 0.0 ± 0.0
Val	5.454ValAla: 5.454 ± 0.077	0.516ValCys: 0.516 ± 0.023	3.76ValAsp: 3.76 ± 0.064	4.795ValGlu: 4.795 ± 0.087	2.831ValPhe: 2.831 ± 0.05	4.815ValGly: 4.815 ± 0.072	1.04ValHis: 1.04 ± 0.031	5.275ValIle: 5.275 ± 0.084	4.419ValLys: 4.419 ± 0.065	6.466ValLeu: 6.466 ± 0.078	1.711ValMet: 1.711 ± 0.042	3.002ValAsn: 3.002 ± 0.06	2.674ValPro: 2.674 ± 0.056	2.181ValGln: 2.181 ± 0.049	2.103ValArg: 2.103 ± 0.045	4.699ValSer: 4.699 ± 0.07	4.697ValThr: 4.697 ± 0.095	5.019ValVal: 5.019 ± 0.076	0.516ValTrp: 0.516 ± 0.022	2.205ValTyr: 2.205 ± 0.05	0.0ValXaa: 0.0 ± 0.0
Trp	0.533TrpAla: 0.533 ± 0.027	0.046TrpCys: 0.046 ± 0.007	0.499TrpAsp: 0.499 ± 0.023	0.612TrpGlu: 0.612 ± 0.029	0.441TrpPhe: 0.441 ± 0.025	0.624TrpGly: 0.624 ± 0.028	0.167TrpHis: 0.167 ± 0.014	0.697TrpIle: 0.697 ± 0.028	0.546TrpLys: 0.546 ± 0.023	1.02TrpLeu: 1.02 ± 0.034	0.242TrpMet: 0.242 ± 0.017	0.487TrpAsn: 0.487 ± 0.028	0.186TrpPro: 0.186 ± 0.013	0.472TrpGln: 0.472 ± 0.022	0.334TrpArg: 0.334 ± 0.016	0.629TrpSer: 0.629 ± 0.028	0.546TrpThr: 0.546 ± 0.023	0.531TrpVal: 0.531 ± 0.024	0.105TrpTrp: 0.105 ± 0.011	0.309TrpTyr: 0.309 ± 0.017	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.138TyrAla: 2.138 ± 0.043	0.254TyrCys: 0.254 ± 0.016	1.897TyrAsp: 1.897 ± 0.047	2.271TyrGlu: 2.271 ± 0.048	2.165TyrPhe: 2.165 ± 0.057	2.336TyrGly: 2.336 ± 0.046	0.776TyrHis: 0.776 ± 0.032	2.272TyrIle: 2.272 ± 0.054	1.932TyrLys: 1.932 ± 0.052	3.998TyrLeu: 3.998 ± 0.077	0.724TyrMet: 0.724 ± 0.027	1.543TyrAsn: 1.543 ± 0.039	1.4TyrPro: 1.4 ± 0.038	2.233TyrGln: 2.233 ± 0.052	1.514TyrArg: 1.514 ± 0.041	2.415TyrSer: 2.415 ± 0.054	2.114TyrThr: 2.114 ± 0.057	2.213TyrVal: 2.213 ± 0.054	0.37TyrTrp: 0.37 ± 0.022	1.587TyrTyr: 1.587 ± 0.049	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3539 proteins (1025100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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