Amino acid dipepetide frequency for Mycobacterium virus lockley

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.008AlaAla: 12.008 ± 1.222
0.569AlaCys: 0.569 ± 0.204
6.636AlaAsp: 6.636 ± 0.609
6.446AlaGlu: 6.446 ± 0.669
3.034AlaPhe: 3.034 ± 0.478
7.521AlaGly: 7.521 ± 0.931
1.643AlaHis: 1.643 ± 0.379
3.982AlaIle: 3.982 ± 0.537
4.614AlaLys: 4.614 ± 0.568
9.101AlaLeu: 9.101 ± 1.026
2.654AlaMet: 2.654 ± 0.378
2.465AlaAsn: 2.465 ± 0.368
4.993AlaPro: 4.993 ± 0.68
2.718AlaGln: 2.718 ± 0.456
6.257AlaArg: 6.257 ± 0.651
4.93AlaSer: 4.93 ± 0.608
5.372AlaThr: 5.372 ± 0.595
8.532AlaVal: 8.532 ± 0.811
1.77AlaTrp: 1.77 ± 0.409
2.781AlaTyr: 2.781 ± 0.353
0.0AlaXaa: 0.0 ± 0.0
Cys
0.569CysAla: 0.569 ± 0.198
0.063CysCys: 0.063 ± 0.056
0.632CysAsp: 0.632 ± 0.204
0.569CysGlu: 0.569 ± 0.179
0.126CysPhe: 0.126 ± 0.086
0.822CysGly: 0.822 ± 0.24
0.126CysHis: 0.126 ± 0.086
0.126CysIle: 0.126 ± 0.085
0.19CysLys: 0.19 ± 0.148
0.442CysLeu: 0.442 ± 0.227
0.063CysMet: 0.063 ± 0.065
0.316CysAsn: 0.316 ± 0.136
0.316CysPro: 0.316 ± 0.141
0.316CysGln: 0.316 ± 0.119
0.632CysArg: 0.632 ± 0.187
0.442CysSer: 0.442 ± 0.176
0.316CysThr: 0.316 ± 0.132
0.316CysVal: 0.316 ± 0.17
0.253CysTrp: 0.253 ± 0.133
0.063CysTyr: 0.063 ± 0.063
0.0CysXaa: 0.0 ± 0.0
Asp
6.51AspAla: 6.51 ± 0.561
0.506AspCys: 0.506 ± 0.188
4.866AspAsp: 4.866 ± 0.57
3.855AspGlu: 3.855 ± 0.537
2.465AspPhe: 2.465 ± 0.366
6.194AspGly: 6.194 ± 0.59
1.327AspHis: 1.327 ± 0.277
3.034AspIle: 3.034 ± 0.494
2.844AspLys: 2.844 ± 0.497
6.826AspLeu: 6.826 ± 0.75
1.39AspMet: 1.39 ± 0.262
1.833AspAsn: 1.833 ± 0.339
4.866AspPro: 4.866 ± 0.569
1.58AspGln: 1.58 ± 0.348
3.476AspArg: 3.476 ± 0.424
2.781AspSer: 2.781 ± 0.455
3.729AspThr: 3.729 ± 0.372
4.74AspVal: 4.74 ± 0.5
2.149AspTrp: 2.149 ± 0.371
2.022AspTyr: 2.022 ± 0.389
0.0AspXaa: 0.0 ± 0.0
Glu
5.941GluAla: 5.941 ± 0.627
0.379GluCys: 0.379 ± 0.156
4.93GluAsp: 4.93 ± 0.533
5.119GluGlu: 5.119 ± 0.636
2.149GluPhe: 2.149 ± 0.39
4.171GluGly: 4.171 ± 0.536
1.706GluHis: 1.706 ± 0.383
3.729GluIle: 3.729 ± 0.472
2.528GluLys: 2.528 ± 0.424
6.573GluLeu: 6.573 ± 0.617
1.643GluMet: 1.643 ± 0.325
1.517GluAsn: 1.517 ± 0.353
2.718GluPro: 2.718 ± 0.429
2.718GluGln: 2.718 ± 0.424
4.108GluArg: 4.108 ± 0.618
3.413GluSer: 3.413 ± 0.482
3.729GluThr: 3.729 ± 0.509
5.498GluVal: 5.498 ± 0.568
1.327GluTrp: 1.327 ± 0.324
2.528GluTyr: 2.528 ± 0.457
0.0GluXaa: 0.0 ± 0.0
Phe
2.591PheAla: 2.591 ± 0.504
0.253PheCys: 0.253 ± 0.114
3.097PheAsp: 3.097 ± 0.343
2.402PheGlu: 2.402 ± 0.357
0.695PhePhe: 0.695 ± 0.191
3.792PheGly: 3.792 ± 0.503
0.569PheHis: 0.569 ± 0.232
1.327PheIle: 1.327 ± 0.284
1.39PheLys: 1.39 ± 0.279
2.465PheLeu: 2.465 ± 0.435
0.569PheMet: 0.569 ± 0.186
1.138PheAsn: 1.138 ± 0.307
1.58PhePro: 1.58 ± 0.28
0.758PheGln: 0.758 ± 0.217
1.896PheArg: 1.896 ± 0.365
1.833PheSer: 1.833 ± 0.302
2.022PheThr: 2.022 ± 0.355
1.959PheVal: 1.959 ± 0.378
0.506PheTrp: 0.506 ± 0.166
0.885PheTyr: 0.885 ± 0.245
0.0PheXaa: 0.0 ± 0.0
Gly
7.837GlyAla: 7.837 ± 1.277
0.632GlyCys: 0.632 ± 0.208
6.13GlyAsp: 6.13 ± 0.583
4.93GlyGlu: 4.93 ± 0.506
2.781GlyPhe: 2.781 ± 0.452
9.859GlyGly: 9.859 ± 2.494
1.643GlyHis: 1.643 ± 0.336
4.298GlyIle: 4.298 ± 0.699
3.792GlyLys: 3.792 ± 0.617
7.394GlyLeu: 7.394 ± 0.804
2.022GlyMet: 2.022 ± 0.448
3.223GlyAsn: 3.223 ± 0.435
3.476GlyPro: 3.476 ± 0.527
2.338GlyGln: 2.338 ± 0.323
4.866GlyArg: 4.866 ± 0.628
6.067GlySer: 6.067 ± 0.726
4.74GlyThr: 4.74 ± 0.68
5.372GlyVal: 5.372 ± 0.487
2.654GlyTrp: 2.654 ± 0.394
2.907GlyTyr: 2.907 ± 0.415
0.0GlyXaa: 0.0 ± 0.0
His
1.896HisAla: 1.896 ± 0.393
0.126HisCys: 0.126 ± 0.124
1.39HisAsp: 1.39 ± 0.27
1.39HisGlu: 1.39 ± 0.309
0.569HisPhe: 0.569 ± 0.181
1.39HisGly: 1.39 ± 0.37
0.569HisHis: 0.569 ± 0.221
0.822HisIle: 0.822 ± 0.226
0.948HisLys: 0.948 ± 0.258
1.706HisLeu: 1.706 ± 0.426
0.19HisMet: 0.19 ± 0.107
0.316HisAsn: 0.316 ± 0.122
1.264HisPro: 1.264 ± 0.282
1.074HisGln: 1.074 ± 0.297
1.58HisArg: 1.58 ± 0.313
0.632HisSer: 0.632 ± 0.198
1.138HisThr: 1.138 ± 0.247
1.77HisVal: 1.77 ± 0.351
0.506HisTrp: 0.506 ± 0.171
0.632HisTyr: 0.632 ± 0.206
0.0HisXaa: 0.0 ± 0.0
Ile
5.562IleAla: 5.562 ± 0.672
0.253IleCys: 0.253 ± 0.125
3.476IleAsp: 3.476 ± 0.388
3.539IleGlu: 3.539 ± 0.537
1.138IlePhe: 1.138 ± 0.293
3.982IleGly: 3.982 ± 0.475
0.822IleHis: 0.822 ± 0.201
1.39IleIle: 1.39 ± 0.257
2.022IleLys: 2.022 ± 0.348
3.476IleLeu: 3.476 ± 0.465
0.695IleMet: 0.695 ± 0.186
1.833IleAsn: 1.833 ± 0.359
3.286IlePro: 3.286 ± 0.455
1.454IleGln: 1.454 ± 0.322
3.539IleArg: 3.539 ± 0.455
3.35IleSer: 3.35 ± 0.514
3.602IleThr: 3.602 ± 0.528
3.286IleVal: 3.286 ± 0.527
0.822IleTrp: 0.822 ± 0.182
1.58IleTyr: 1.58 ± 0.291
0.0IleXaa: 0.0 ± 0.0
Lys
4.108LysAla: 4.108 ± 0.544
0.442LysCys: 0.442 ± 0.175
2.528LysAsp: 2.528 ± 0.501
2.149LysGlu: 2.149 ± 0.415
1.39LysPhe: 1.39 ± 0.231
2.718LysGly: 2.718 ± 0.428
1.011LysHis: 1.011 ± 0.315
2.465LysIle: 2.465 ± 0.444
1.706LysLys: 1.706 ± 0.444
3.476LysLeu: 3.476 ± 0.427
1.011LysMet: 1.011 ± 0.203
1.454LysAsn: 1.454 ± 0.297
2.654LysPro: 2.654 ± 0.472
1.833LysGln: 1.833 ± 0.452
3.034LysArg: 3.034 ± 0.477
2.402LysSer: 2.402 ± 0.437
2.528LysThr: 2.528 ± 0.412
3.476LysVal: 3.476 ± 0.507
0.569LysTrp: 0.569 ± 0.194
1.201LysTyr: 1.201 ± 0.37
0.0LysXaa: 0.0 ± 0.0
Leu
9.101LeuAla: 9.101 ± 0.866
0.316LeuCys: 0.316 ± 0.148
6.257LeuAsp: 6.257 ± 0.618
5.562LeuGlu: 5.562 ± 0.654
2.275LeuPhe: 2.275 ± 0.361
6.889LeuGly: 6.889 ± 0.71
1.454LeuHis: 1.454 ± 0.299
4.93LeuIle: 4.93 ± 0.59
4.234LeuLys: 4.234 ± 0.494
5.878LeuLeu: 5.878 ± 0.568
1.833LeuMet: 1.833 ± 0.328
3.034LeuAsn: 3.034 ± 0.359
5.751LeuPro: 5.751 ± 0.608
2.781LeuGln: 2.781 ± 0.474
5.814LeuArg: 5.814 ± 0.556
5.562LeuSer: 5.562 ± 0.616
5.878LeuThr: 5.878 ± 0.482
4.55LeuVal: 4.55 ± 0.567
0.822LeuTrp: 0.822 ± 0.286
2.528LeuTyr: 2.528 ± 0.479
0.0LeuXaa: 0.0 ± 0.0
Met
2.528MetAla: 2.528 ± 0.379
0.063MetCys: 0.063 ± 0.065
0.885MetAsp: 0.885 ± 0.229
1.58MetGlu: 1.58 ± 0.294
0.758MetPhe: 0.758 ± 0.195
1.643MetGly: 1.643 ± 0.316
0.316MetHis: 0.316 ± 0.165
0.569MetIle: 0.569 ± 0.183
1.264MetLys: 1.264 ± 0.302
1.074MetLeu: 1.074 ± 0.267
0.126MetMet: 0.126 ± 0.089
1.138MetAsn: 1.138 ± 0.209
1.011MetPro: 1.011 ± 0.271
0.632MetGln: 0.632 ± 0.208
1.074MetArg: 1.074 ± 0.248
2.086MetSer: 2.086 ± 0.398
2.275MetThr: 2.275 ± 0.349
0.885MetVal: 0.885 ± 0.233
0.253MetTrp: 0.253 ± 0.108
0.506MetTyr: 0.506 ± 0.188
0.0MetXaa: 0.0 ± 0.0
Asn
3.35AsnAla: 3.35 ± 0.505
0.063AsnCys: 0.063 ± 0.074
2.086AsnAsp: 2.086 ± 0.347
1.959AsnGlu: 1.959 ± 0.384
1.011AsnPhe: 1.011 ± 0.283
3.16AsnGly: 3.16 ± 0.456
0.758AsnHis: 0.758 ± 0.189
1.77AsnIle: 1.77 ± 0.337
0.695AsnLys: 0.695 ± 0.251
2.528AsnLeu: 2.528 ± 0.342
0.506AsnMet: 0.506 ± 0.155
0.948AsnAsn: 0.948 ± 0.23
2.718AsnPro: 2.718 ± 0.379
1.011AsnGln: 1.011 ± 0.264
1.201AsnArg: 1.201 ± 0.337
1.643AsnSer: 1.643 ± 0.306
1.959AsnThr: 1.959 ± 0.358
2.465AsnVal: 2.465 ± 0.395
0.758AsnTrp: 0.758 ± 0.193
1.264AsnTyr: 1.264 ± 0.28
0.0AsnXaa: 0.0 ± 0.0
Pro
5.309ProAla: 5.309 ± 0.574
0.442ProCys: 0.442 ± 0.175
4.171ProAsp: 4.171 ± 0.509
4.298ProGlu: 4.298 ± 0.558
2.275ProPhe: 2.275 ± 0.355
5.119ProGly: 5.119 ± 0.626
1.264ProHis: 1.264 ± 0.324
2.718ProIle: 2.718 ± 0.382
1.896ProLys: 1.896 ± 0.288
4.361ProLeu: 4.361 ± 0.524
1.011ProMet: 1.011 ± 0.225
1.643ProAsn: 1.643 ± 0.3
3.097ProPro: 3.097 ± 0.513
1.706ProGln: 1.706 ± 0.383
2.718ProArg: 2.718 ± 0.504
3.855ProSer: 3.855 ± 0.456
3.413ProThr: 3.413 ± 0.472
3.729ProVal: 3.729 ± 0.478
0.885ProTrp: 0.885 ± 0.256
1.58ProTyr: 1.58 ± 0.344
0.0ProXaa: 0.0 ± 0.0
Gln
2.591GlnAla: 2.591 ± 0.448
0.19GlnCys: 0.19 ± 0.12
1.454GlnAsp: 1.454 ± 0.389
1.706GlnGlu: 1.706 ± 0.288
1.264GlnPhe: 1.264 ± 0.24
2.275GlnGly: 2.275 ± 0.3
0.506GlnHis: 0.506 ± 0.168
2.465GlnIle: 2.465 ± 0.524
1.264GlnLys: 1.264 ± 0.292
3.792GlnLeu: 3.792 ± 0.479
1.138GlnMet: 1.138 ± 0.319
0.442GlnAsn: 0.442 ± 0.15
1.959GlnPro: 1.959 ± 0.401
1.77GlnGln: 1.77 ± 0.391
1.706GlnArg: 1.706 ± 0.361
1.896GlnSer: 1.896 ± 0.348
2.022GlnThr: 2.022 ± 0.421
2.781GlnVal: 2.781 ± 0.392
0.758GlnTrp: 0.758 ± 0.185
0.695GlnTyr: 0.695 ± 0.174
0.0GlnXaa: 0.0 ± 0.0
Arg
5.562ArgAla: 5.562 ± 0.753
0.632ArgCys: 0.632 ± 0.206
2.907ArgAsp: 2.907 ± 0.434
4.803ArgGlu: 4.803 ± 0.597
2.022ArgPhe: 2.022 ± 0.364
5.119ArgGly: 5.119 ± 0.659
1.264ArgHis: 1.264 ± 0.253
2.97ArgIle: 2.97 ± 0.501
3.539ArgLys: 3.539 ± 0.604
5.688ArgLeu: 5.688 ± 0.736
1.77ArgMet: 1.77 ± 0.37
2.149ArgAsn: 2.149 ± 0.416
2.275ArgPro: 2.275 ± 0.404
1.959ArgGln: 1.959 ± 0.367
5.562ArgArg: 5.562 ± 0.7
3.286ArgSer: 3.286 ± 0.567
2.654ArgThr: 2.654 ± 0.507
5.056ArgVal: 5.056 ± 0.584
1.327ArgTrp: 1.327 ± 0.305
1.706ArgTyr: 1.706 ± 0.297
0.0ArgXaa: 0.0 ± 0.0
Ser
6.32SerAla: 6.32 ± 0.852
0.569SerCys: 0.569 ± 0.19
3.097SerAsp: 3.097 ± 0.424
3.855SerGlu: 3.855 ± 0.475
2.086SerPhe: 2.086 ± 0.448
5.941SerGly: 5.941 ± 0.748
1.517SerHis: 1.517 ± 0.316
2.844SerIle: 2.844 ± 0.473
2.465SerLys: 2.465 ± 0.441
4.677SerLeu: 4.677 ± 0.587
1.264SerMet: 1.264 ± 0.233
2.465SerAsn: 2.465 ± 0.451
3.097SerPro: 3.097 ± 0.532
1.959SerGln: 1.959 ± 0.316
3.097SerArg: 3.097 ± 0.36
3.792SerSer: 3.792 ± 0.893
3.097SerThr: 3.097 ± 0.461
4.171SerVal: 4.171 ± 0.625
1.264SerTrp: 1.264 ± 0.317
1.643SerTyr: 1.643 ± 0.325
0.0SerXaa: 0.0 ± 0.0
Thr
5.435ThrAla: 5.435 ± 0.761
0.316ThrCys: 0.316 ± 0.143
4.361ThrAsp: 4.361 ± 0.583
4.045ThrGlu: 4.045 ± 0.495
1.77ThrPhe: 1.77 ± 0.34
6.826ThrGly: 6.826 ± 0.653
1.011ThrHis: 1.011 ± 0.314
2.844ThrIle: 2.844 ± 0.574
2.591ThrLys: 2.591 ± 0.321
5.751ThrLeu: 5.751 ± 0.663
0.822ThrMet: 0.822 ± 0.257
1.58ThrAsn: 1.58 ± 0.304
3.602ThrPro: 3.602 ± 0.503
1.706ThrGln: 1.706 ± 0.365
3.223ThrArg: 3.223 ± 0.535
3.413ThrSer: 3.413 ± 0.653
4.361ThrThr: 4.361 ± 0.642
5.246ThrVal: 5.246 ± 0.592
0.948ThrTrp: 0.948 ± 0.255
2.149ThrTyr: 2.149 ± 0.393
0.0ThrXaa: 0.0 ± 0.0
Val
6.762ValAla: 6.762 ± 0.581
0.506ValCys: 0.506 ± 0.148
5.372ValAsp: 5.372 ± 0.558
5.056ValGlu: 5.056 ± 0.507
2.212ValPhe: 2.212 ± 0.391
5.056ValGly: 5.056 ± 0.809
1.39ValHis: 1.39 ± 0.24
4.108ValIle: 4.108 ± 0.499
2.591ValLys: 2.591 ± 0.41
5.372ValLeu: 5.372 ± 0.623
1.011ValMet: 1.011 ± 0.288
2.528ValAsn: 2.528 ± 0.414
4.234ValPro: 4.234 ± 0.527
2.212ValGln: 2.212 ± 0.347
4.803ValArg: 4.803 ± 0.596
5.435ValSer: 5.435 ± 0.596
5.562ValThr: 5.562 ± 0.65
4.74ValVal: 4.74 ± 0.61
1.264ValTrp: 1.264 ± 0.257
2.212ValTyr: 2.212 ± 0.437
0.0ValXaa: 0.0 ± 0.0
Trp
1.706TrpAla: 1.706 ± 0.32
0.126TrpCys: 0.126 ± 0.094
1.39TrpAsp: 1.39 ± 0.293
0.822TrpGlu: 0.822 ± 0.212
0.948TrpPhe: 0.948 ± 0.24
1.77TrpGly: 1.77 ± 0.387
0.379TrpHis: 0.379 ± 0.147
1.138TrpIle: 1.138 ± 0.268
0.379TrpLys: 0.379 ± 0.213
1.896TrpLeu: 1.896 ± 0.363
0.379TrpMet: 0.379 ± 0.158
0.506TrpAsn: 0.506 ± 0.167
0.948TrpPro: 0.948 ± 0.233
0.885TrpGln: 0.885 ± 0.214
1.138TrpArg: 1.138 ± 0.293
0.885TrpSer: 0.885 ± 0.283
1.454TrpThr: 1.454 ± 0.292
2.086TrpVal: 2.086 ± 0.345
0.506TrpTrp: 0.506 ± 0.198
0.442TrpTyr: 0.442 ± 0.169
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.402TyrAla: 2.402 ± 0.379
0.253TyrCys: 0.253 ± 0.168
1.327TyrAsp: 1.327 ± 0.332
2.338TyrGlu: 2.338 ± 0.369
0.758TyrPhe: 0.758 ± 0.211
2.718TyrGly: 2.718 ± 0.471
0.632TyrHis: 0.632 ± 0.213
1.58TyrIle: 1.58 ± 0.323
1.201TyrLys: 1.201 ± 0.29
2.97TyrLeu: 2.97 ± 0.47
0.506TyrMet: 0.506 ± 0.168
1.327TyrAsn: 1.327 ± 0.309
1.643TyrPro: 1.643 ± 0.332
1.264TyrGln: 1.264 ± 0.304
2.528TyrArg: 2.528 ± 0.361
1.517TyrSer: 1.517 ± 0.292
2.149TyrThr: 2.149 ± 0.428
1.77TyrVal: 1.77 ± 0.33
0.442TyrTrp: 0.442 ± 0.168
0.885TyrTyr: 0.885 ± 0.259
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 90 proteins (15824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski