Amino acid dipepetide frequency for Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.375AlaAla: 6.375 ± 0.12
0.956AlaCys: 0.956 ± 0.034
3.981AlaAsp: 3.981 ± 0.078
5.804AlaGlu: 5.804 ± 0.106
3.54AlaPhe: 3.54 ± 0.074
5.273AlaGly: 5.273 ± 0.093
1.032AlaHis: 1.032 ± 0.04
4.762AlaIle: 4.762 ± 0.091
5.025AlaLys: 5.025 ± 0.085
7.263AlaLeu: 7.263 ± 0.11
1.599AlaMet: 1.599 ± 0.041
2.481AlaAsn: 2.481 ± 0.054
1.851AlaPro: 1.851 ± 0.056
2.036AlaGln: 2.036 ± 0.049
2.487AlaArg: 2.487 ± 0.061
4.648AlaSer: 4.648 ± 0.085
1.978AlaThr: 1.978 ± 0.06
5.557AlaVal: 5.557 ± 0.085
0.57AlaTrp: 0.57 ± 0.023
2.564AlaTyr: 2.564 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
0.702CysAla: 0.702 ± 0.032
0.156CysCys: 0.156 ± 0.014
0.574CysAsp: 0.574 ± 0.027
0.688CysGlu: 0.688 ± 0.029
0.753CysPhe: 0.753 ± 0.032
0.983CysGly: 0.983 ± 0.044
0.179CysHis: 0.179 ± 0.016
1.011CysIle: 1.011 ± 0.036
0.892CysLys: 0.892 ± 0.035
1.014CysLeu: 1.014 ± 0.038
0.245CysMet: 0.245 ± 0.018
0.541CysAsn: 0.541 ± 0.022
0.5CysPro: 0.5 ± 0.03
0.177CysGln: 0.177 ± 0.015
0.523CysArg: 0.523 ± 0.022
0.841CysSer: 0.841 ± 0.033
0.621CysThr: 0.621 ± 0.028
0.628CysVal: 0.628 ± 0.027
0.095CysTrp: 0.095 ± 0.011
0.431CysTyr: 0.431 ± 0.024
0.0CysXaa: 0.0 ± 0.0
Asp
3.466AspAla: 3.466 ± 0.061
0.586AspCys: 0.586 ± 0.03
2.737AspAsp: 2.737 ± 0.089
4.423AspGlu: 4.423 ± 0.094
3.338AspPhe: 3.338 ± 0.079
3.481AspGly: 3.481 ± 0.09
0.52AspHis: 0.52 ± 0.024
4.982AspIle: 4.982 ± 0.088
4.463AspLys: 4.463 ± 0.066
4.787AspLeu: 4.787 ± 0.08
1.35AspMet: 1.35 ± 0.038
2.333AspAsn: 2.333 ± 0.064
1.688AspPro: 1.688 ± 0.049
0.849AspGln: 0.849 ± 0.034
1.864AspArg: 1.864 ± 0.048
3.514AspSer: 3.514 ± 0.066
2.581AspThr: 2.581 ± 0.054
3.03AspVal: 3.03 ± 0.067
0.63AspTrp: 0.63 ± 0.028
2.381AspTyr: 2.381 ± 0.061
0.0AspXaa: 0.0 ± 0.0
Glu
5.346GluAla: 5.346 ± 0.09
0.578GluCys: 0.578 ± 0.028
3.781GluAsp: 3.781 ± 0.084
5.719GluGlu: 5.719 ± 0.111
3.143GluPhe: 3.143 ± 0.066
4.004GluGly: 4.004 ± 0.089
1.12GluHis: 1.12 ± 0.043
6.057GluIle: 6.057 ± 0.089
8.126GluLys: 8.126 ± 0.12
6.345GluLeu: 6.345 ± 0.1
1.728GluMet: 1.728 ± 0.05
4.715GluAsn: 4.715 ± 0.075
1.868GluPro: 1.868 ± 0.052
1.936GluGln: 1.936 ± 0.053
2.804GluArg: 2.804 ± 0.062
3.548GluSer: 3.548 ± 0.069
3.635GluThr: 3.635 ± 0.076
3.762GluVal: 3.762 ± 0.076
0.661GluTrp: 0.661 ± 0.034
2.748GluTyr: 2.748 ± 0.062
0.0GluXaa: 0.0 ± 0.0
Phe
3.645PheAla: 3.645 ± 0.073
0.749PheCys: 0.749 ± 0.033
2.956PheAsp: 2.956 ± 0.063
3.207PheGlu: 3.207 ± 0.068
3.759PhePhe: 3.759 ± 0.1
2.992PheGly: 2.992 ± 0.068
0.636PheHis: 0.636 ± 0.028
4.618PheIle: 4.618 ± 0.082
3.791PheLys: 3.791 ± 0.068
5.588PheLeu: 5.588 ± 0.101
1.285PheMet: 1.285 ± 0.039
2.492PheAsn: 2.492 ± 0.064
1.695PhePro: 1.695 ± 0.044
1.196PheGln: 1.196 ± 0.036
1.597PheArg: 1.597 ± 0.042
4.64PheSer: 4.64 ± 0.097
2.863PheThr: 2.863 ± 0.067
2.903PheVal: 2.903 ± 0.068
0.526PheTrp: 0.526 ± 0.028
2.419PheTyr: 2.419 ± 0.065
0.0PheXaa: 0.0 ± 0.0
Gly
4.083GlyAla: 4.083 ± 0.094
0.881GlyCys: 0.881 ± 0.038
2.907GlyAsp: 2.907 ± 0.064
3.996GlyGlu: 3.996 ± 0.07
3.58GlyPhe: 3.58 ± 0.064
4.485GlyGly: 4.485 ± 0.108
0.932GlyHis: 0.932 ± 0.031
5.6GlyIle: 5.6 ± 0.093
5.921GlyLys: 5.921 ± 0.079
6.188GlyLeu: 6.188 ± 0.111
1.649GlyMet: 1.649 ± 0.044
3.026GlyAsn: 3.026 ± 0.069
1.231GlyPro: 1.231 ± 0.037
1.535GlyGln: 1.535 ± 0.042
2.549GlyArg: 2.549 ± 0.057
4.261GlySer: 4.261 ± 0.085
3.6GlyThr: 3.6 ± 0.084
3.644GlyVal: 3.644 ± 0.077
0.611GlyTrp: 0.611 ± 0.029
2.384GlyTyr: 2.384 ± 0.056
0.0GlyXaa: 0.0 ± 0.0
His
0.963HisAla: 0.963 ± 0.03
0.23HisCys: 0.23 ± 0.017
0.753HisAsp: 0.753 ± 0.031
0.831HisGlu: 0.831 ± 0.034
0.831HisPhe: 0.831 ± 0.032
1.0HisGly: 1.0 ± 0.038
0.273HisHis: 0.273 ± 0.017
1.328HisIle: 1.328 ± 0.035
1.033HisLys: 1.033 ± 0.037
1.417HisLeu: 1.417 ± 0.039
0.247HisMet: 0.247 ± 0.017
0.753HisAsn: 0.753 ± 0.03
0.741HisPro: 0.741 ± 0.031
0.434HisGln: 0.434 ± 0.022
0.625HisArg: 0.625 ± 0.024
0.965HisSer: 0.965 ± 0.039
0.764HisThr: 0.764 ± 0.032
0.675HisVal: 0.675 ± 0.031
0.124HisTrp: 0.124 ± 0.013
0.562HisTyr: 0.562 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
5.93IleAla: 5.93 ± 0.094
1.0IleCys: 1.0 ± 0.035
4.539IleAsp: 4.539 ± 0.085
6.256IleGlu: 6.256 ± 0.106
4.74IlePhe: 4.74 ± 0.091
5.07IleGly: 5.07 ± 0.087
1.226IleHis: 1.226 ± 0.04
7.24IleIle: 7.24 ± 0.12
7.151IleLys: 7.151 ± 0.107
8.336IleLeu: 8.336 ± 0.147
1.763IleMet: 1.763 ± 0.045
4.192IleAsn: 4.192 ± 0.08
3.533IlePro: 3.533 ± 0.069
2.268IleGln: 2.268 ± 0.057
3.125IleArg: 3.125 ± 0.065
6.365IleSer: 6.365 ± 0.112
4.364IleThr: 4.364 ± 0.085
4.513IleVal: 4.513 ± 0.089
0.545IleTrp: 0.545 ± 0.029
3.013IleTyr: 3.013 ± 0.064
0.0IleXaa: 0.0 ± 0.0
Lys
5.898LysAla: 5.898 ± 0.098
0.632LysCys: 0.632 ± 0.025
4.875LysAsp: 4.875 ± 0.082
7.311LysGlu: 7.311 ± 0.1
3.015LysPhe: 3.015 ± 0.058
4.355LysGly: 4.355 ± 0.077
1.205LysHis: 1.205 ± 0.04
8.046LysIle: 8.046 ± 0.11
9.196LysLys: 9.196 ± 0.111
6.988LysLeu: 6.988 ± 0.096
2.2LysMet: 2.2 ± 0.051
6.224LysAsn: 6.224 ± 0.093
2.665LysPro: 2.665 ± 0.057
2.434LysGln: 2.434 ± 0.052
3.449LysArg: 3.449 ± 0.063
4.424LysSer: 4.424 ± 0.063
5.689LysThr: 5.689 ± 0.083
3.794LysVal: 3.794 ± 0.072
0.638LysTrp: 0.638 ± 0.028
3.156LysTyr: 3.156 ± 0.07
0.0LysXaa: 0.0 ± 0.0
Leu
6.381LeuAla: 6.381 ± 0.083
1.241LeuCys: 1.241 ± 0.044
4.929LeuAsp: 4.929 ± 0.094
5.836LeuGlu: 5.836 ± 0.104
5.418LeuPhe: 5.418 ± 0.108
5.452LeuGly: 5.452 ± 0.093
1.438LeuHis: 1.438 ± 0.038
7.956LeuIle: 7.956 ± 0.136
8.728LeuLys: 8.728 ± 0.115
8.92LeuLeu: 8.92 ± 0.144
2.234LeuMet: 2.234 ± 0.059
5.164LeuAsn: 5.164 ± 0.088
3.869LeuPro: 3.869 ± 0.062
2.707LeuGln: 2.707 ± 0.066
3.517LeuArg: 3.517 ± 0.066
7.624LeuSer: 7.624 ± 0.11
4.904LeuThr: 4.904 ± 0.086
4.808LeuVal: 4.808 ± 0.08
0.787LeuTrp: 0.787 ± 0.033
3.679LeuTyr: 3.679 ± 0.07
0.0LeuXaa: 0.0 ± 0.0
Met
1.524MetAla: 1.524 ± 0.048
0.223MetCys: 0.223 ± 0.019
1.204MetAsp: 1.204 ± 0.04
1.623MetGlu: 1.623 ± 0.047
0.975MetPhe: 0.975 ± 0.038
1.603MetGly: 1.603 ± 0.051
0.359MetHis: 0.359 ± 0.019
1.855MetIle: 1.855 ± 0.056
2.135MetLys: 2.135 ± 0.057
2.18MetLeu: 2.18 ± 0.049
0.587MetMet: 0.587 ± 0.03
1.279MetAsn: 1.279 ± 0.035
1.024MetPro: 1.024 ± 0.038
0.925MetGln: 0.925 ± 0.035
1.012MetArg: 1.012 ± 0.035
1.583MetSer: 1.583 ± 0.044
1.188MetThr: 1.188 ± 0.036
1.159MetVal: 1.159 ± 0.039
0.135MetTrp: 0.135 ± 0.013
0.863MetTyr: 0.863 ± 0.035
0.0MetXaa: 0.0 ± 0.0
Asn
3.232AsnAla: 3.232 ± 0.066
0.575AsnCys: 0.575 ± 0.03
2.364AsnAsp: 2.364 ± 0.056
3.513AsnGlu: 3.513 ± 0.068
2.719AsnPhe: 2.719 ± 0.068
3.026AsnGly: 3.026 ± 0.065
0.619AsnHis: 0.619 ± 0.026
5.082AsnIle: 5.082 ± 0.098
4.256AsnLys: 4.256 ± 0.08
5.22AsnLeu: 5.22 ± 0.084
1.325AsnMet: 1.325 ± 0.037
2.588AsnAsn: 2.588 ± 0.067
2.208AsnPro: 2.208 ± 0.051
1.351AsnGln: 1.351 ± 0.044
1.951AsnArg: 1.951 ± 0.047
3.416AsnSer: 3.416 ± 0.069
2.779AsnThr: 2.779 ± 0.067
2.457AsnVal: 2.457 ± 0.06
0.492AsnTrp: 0.492 ± 0.024
2.089AsnTyr: 2.089 ± 0.057
0.0AsnXaa: 0.0 ± 0.0
Pro
2.523ProAla: 2.523 ± 0.065
0.346ProCys: 0.346 ± 0.022
2.176ProAsp: 2.176 ± 0.059
3.143ProGlu: 3.143 ± 0.068
1.854ProPhe: 1.854 ± 0.058
1.709ProGly: 1.709 ± 0.048
0.644ProHis: 0.644 ± 0.023
2.762ProIle: 2.762 ± 0.056
2.425ProLys: 2.425 ± 0.058
3.093ProLeu: 3.093 ± 0.066
0.746ProMet: 0.746 ± 0.028
1.496ProAsn: 1.496 ± 0.04
1.18ProPro: 1.18 ± 0.046
1.196ProGln: 1.196 ± 0.039
0.995ProArg: 0.995 ± 0.034
2.147ProSer: 2.147 ± 0.052
1.355ProThr: 1.355 ± 0.041
2.637ProVal: 2.637 ± 0.06
0.278ProTrp: 0.278 ± 0.017
1.367ProTyr: 1.367 ± 0.038
0.0ProXaa: 0.0 ± 0.0
Gln
2.09GlnAla: 2.09 ± 0.051
0.223GlnCys: 0.223 ± 0.017
1.372GlnAsp: 1.372 ± 0.041
1.948GlnGlu: 1.948 ± 0.05
1.083GlnPhe: 1.083 ± 0.038
1.777GlnGly: 1.777 ± 0.052
0.365GlnHis: 0.365 ± 0.021
2.242GlnIle: 2.242 ± 0.054
3.099GlnLys: 3.099 ± 0.072
2.067GlnLeu: 2.067 ± 0.05
0.628GlnMet: 0.628 ± 0.026
1.989GlnAsn: 1.989 ± 0.051
0.694GlnPro: 0.694 ± 0.026
0.721GlnGln: 0.721 ± 0.033
1.12GlnArg: 1.12 ± 0.041
1.585GlnSer: 1.585 ± 0.046
1.606GlnThr: 1.606 ± 0.049
1.414GlnVal: 1.414 ± 0.037
0.24GlnTrp: 0.24 ± 0.019
0.958GlnTyr: 0.958 ± 0.035
0.0GlnXaa: 0.0 ± 0.0
Arg
2.577ArgAla: 2.577 ± 0.055
0.421ArgCys: 0.421 ± 0.024
1.746ArgAsp: 1.746 ± 0.043
2.518ArgGlu: 2.518 ± 0.054
2.043ArgPhe: 2.043 ± 0.05
2.17ArgGly: 2.17 ± 0.047
0.551ArgHis: 0.551 ± 0.027
3.433ArgIle: 3.433 ± 0.069
2.998ArgLys: 2.998 ± 0.068
4.026ArgLeu: 4.026 ± 0.072
1.031ArgMet: 1.031 ± 0.038
1.816ArgAsn: 1.816 ± 0.052
1.304ArgPro: 1.304 ± 0.039
1.112ArgGln: 1.112 ± 0.034
1.666ArgArg: 1.666 ± 0.054
2.264ArgSer: 2.264 ± 0.055
1.792ArgThr: 1.792 ± 0.045
2.071ArgVal: 2.071 ± 0.051
0.366ArgTrp: 0.366 ± 0.019
1.638ArgTyr: 1.638 ± 0.053
0.0ArgXaa: 0.0 ± 0.0
Ser
4.665SerAla: 4.665 ± 0.085
0.878SerCys: 0.878 ± 0.033
3.556SerAsp: 3.556 ± 0.067
4.35SerGlu: 4.35 ± 0.083
4.156SerPhe: 4.156 ± 0.085
5.486SerGly: 5.486 ± 0.105
1.006SerHis: 1.006 ± 0.036
5.751SerIle: 5.751 ± 0.084
4.724SerLys: 4.724 ± 0.074
6.929SerLeu: 6.929 ± 0.12
1.484SerMet: 1.484 ± 0.038
2.725SerAsn: 2.725 ± 0.064
2.356SerPro: 2.356 ± 0.055
1.892SerGln: 1.892 ± 0.05
2.256SerArg: 2.256 ± 0.051
5.065SerSer: 5.065 ± 0.101
2.801SerThr: 2.801 ± 0.064
4.46SerVal: 4.46 ± 0.082
0.648SerTrp: 0.648 ± 0.031
2.615SerTyr: 2.615 ± 0.062
0.0SerXaa: 0.0 ± 0.0
Thr
4.454ThrAla: 4.454 ± 0.081
0.442ThrCys: 0.442 ± 0.023
3.029ThrAsp: 3.029 ± 0.068
3.849ThrGlu: 3.849 ± 0.077
2.151ThrPhe: 2.151 ± 0.048
4.128ThrGly: 4.128 ± 0.082
0.829ThrHis: 0.829 ± 0.033
4.106ThrIle: 4.106 ± 0.076
3.484ThrLys: 3.484 ± 0.058
4.366ThrLeu: 4.366 ± 0.086
1.08ThrMet: 1.08 ± 0.033
2.092ThrAsn: 2.092 ± 0.053
1.868ThrPro: 1.868 ± 0.059
1.389ThrGln: 1.389 ± 0.038
1.636ThrArg: 1.636 ± 0.045
3.121ThrSer: 3.121 ± 0.069
2.112ThrThr: 2.112 ± 0.067
3.835ThrVal: 3.835 ± 0.083
0.405ThrTrp: 0.405 ± 0.025
1.633ThrTyr: 1.633 ± 0.05
0.0ThrXaa: 0.0 ± 0.0
Val
2.916ValAla: 2.916 ± 0.077
0.768ValCys: 0.768 ± 0.027
2.631ValAsp: 2.631 ± 0.062
3.44ValGlu: 3.44 ± 0.067
3.765ValPhe: 3.765 ± 0.069
3.011ValGly: 3.011 ± 0.066
0.877ValHis: 0.877 ± 0.034
4.618ValIle: 4.618 ± 0.084
4.764ValLys: 4.764 ± 0.083
6.437ValLeu: 6.437 ± 0.096
1.313ValMet: 1.313 ± 0.044
2.753ValAsn: 2.753 ± 0.061
2.155ValPro: 2.155 ± 0.062
1.713ValGln: 1.713 ± 0.045
2.312ValArg: 2.312 ± 0.054
4.472ValSer: 4.472 ± 0.079
2.714ValThr: 2.714 ± 0.067
3.114ValVal: 3.114 ± 0.071
0.56ValTrp: 0.56 ± 0.025
2.414ValTyr: 2.414 ± 0.046
0.0ValXaa: 0.0 ± 0.0
Trp
0.578TrpAla: 0.578 ± 0.028
0.118TrpCys: 0.118 ± 0.013
0.481TrpAsp: 0.481 ± 0.028
0.592TrpGlu: 0.592 ± 0.027
0.487TrpPhe: 0.487 ± 0.027
0.506TrpGly: 0.506 ± 0.024
0.178TrpHis: 0.178 ± 0.016
0.699TrpIle: 0.699 ± 0.032
0.827TrpLys: 0.827 ± 0.03
0.864TrpLeu: 0.864 ± 0.034
0.214TrpMet: 0.214 ± 0.016
0.543TrpAsn: 0.543 ± 0.026
0.191TrpPro: 0.191 ± 0.014
0.31TrpGln: 0.31 ± 0.019
0.337TrpArg: 0.337 ± 0.018
0.49TrpSer: 0.49 ± 0.025
0.431TrpThr: 0.431 ± 0.023
0.437TrpVal: 0.437 ± 0.025
0.104TrpTrp: 0.104 ± 0.012
0.438TrpTyr: 0.438 ± 0.026
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.435TyrAla: 2.435 ± 0.055
0.547TyrCys: 0.547 ± 0.026
2.412TyrAsp: 2.412 ± 0.064
2.574TyrGlu: 2.574 ± 0.07
2.208TyrPhe: 2.208 ± 0.051
2.552TyrGly: 2.552 ± 0.064
0.56TyrHis: 0.56 ± 0.027
3.023TyrIle: 3.023 ± 0.059
3.159TyrLys: 3.159 ± 0.069
3.563TyrLeu: 3.563 ± 0.068
0.728TyrMet: 0.728 ± 0.028
2.061TyrAsn: 2.061 ± 0.047
1.449TyrPro: 1.449 ± 0.038
1.036TyrGln: 1.036 ± 0.036
1.718TyrArg: 1.718 ± 0.05
2.833TyrSer: 2.833 ± 0.062
2.235TyrThr: 2.235 ± 0.052
1.848TyrVal: 1.848 ± 0.049
0.408TyrTrp: 0.408 ± 0.027
1.656TyrTyr: 1.656 ± 0.05
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2753 proteins (863642 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski