Amino acid dipepetide frequency for Clostridiales bacterium KLE1615

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.783AlaAla: 7.783 ± 0.116	1.121AlaCys: 1.121 ± 0.032	4.641AlaAsp: 4.641 ± 0.06	5.086AlaGlu: 5.086 ± 0.075	3.161AlaPhe: 3.161 ± 0.05	5.435AlaGly: 5.435 ± 0.076	1.252AlaHis: 1.252 ± 0.039	5.03AlaIle: 5.03 ± 0.062	5.155AlaLys: 5.155 ± 0.069	6.746AlaLeu: 6.746 ± 0.084	2.399AlaMet: 2.399 ± 0.044	2.826AlaAsn: 2.826 ± 0.053	2.102AlaPro: 2.102 ± 0.046	2.787AlaGln: 2.787 ± 0.059	2.814AlaArg: 2.814 ± 0.053	4.5AlaSer: 4.5 ± 0.059	3.054AlaThr: 3.054 ± 0.067	6.056AlaVal: 6.056 ± 0.082	0.761AlaTrp: 0.761 ± 0.029	2.938AlaTyr: 2.938 ± 0.05	0.0AlaXaa: 0.0 ± 0.0
Cys	1.155CysAla: 1.155 ± 0.036	0.348CysCys: 0.348 ± 0.019	0.903CysAsp: 0.903 ± 0.034	1.069CysGlu: 1.069 ± 0.029	0.762CysPhe: 0.762 ± 0.026	1.397CysGly: 1.397 ± 0.038	0.338CysHis: 0.338 ± 0.017	1.173CysIle: 1.173 ± 0.036	0.895CysLys: 0.895 ± 0.026	1.283CysLeu: 1.283 ± 0.036	0.491CysMet: 0.491 ± 0.021	0.605CysAsn: 0.605 ± 0.023	0.621CysPro: 0.621 ± 0.026	0.462CysGln: 0.462 ± 0.019	0.782CysArg: 0.782 ± 0.03	0.969CysSer: 0.969 ± 0.033	0.819CysThr: 0.819 ± 0.028	1.17CysVal: 1.17 ± 0.036	0.175CysTrp: 0.175 ± 0.013	0.699CysTyr: 0.699 ± 0.027	0.0CysXaa: 0.0 ± 0.0
Asp	4.28AspAla: 4.28 ± 0.078	0.941AspCys: 0.941 ± 0.029	3.152AspAsp: 3.152 ± 0.058	5.135AspGlu: 5.135 ± 0.074	2.575AspPhe: 2.575 ± 0.05	4.649AspGly: 4.649 ± 0.082	0.995AspHis: 0.995 ± 0.031	4.024AspIle: 4.024 ± 0.062	3.326AspLys: 3.326 ± 0.054	4.457AspLeu: 4.457 ± 0.07	1.765AspMet: 1.765 ± 0.038	2.17AspAsn: 2.17 ± 0.046	1.882AspPro: 1.882 ± 0.044	1.737AspGln: 1.737 ± 0.04	2.298AspArg: 2.298 ± 0.048	3.118AspSer: 3.118 ± 0.054	3.204AspThr: 3.204 ± 0.063	3.589AspVal: 3.589 ± 0.056	0.734AspTrp: 0.734 ± 0.027	2.707AspTyr: 2.707 ± 0.053	0.0AspXaa: 0.0 ± 0.0
Glu	5.659GluAla: 5.659 ± 0.075	0.92GluCys: 0.92 ± 0.031	4.05GluAsp: 4.05 ± 0.069	6.741GluGlu: 6.741 ± 0.117	2.405GluPhe: 2.405 ± 0.049	4.061GluGly: 4.061 ± 0.057	1.423GluHis: 1.423 ± 0.037	5.06GluIle: 5.06 ± 0.067	6.513GluLys: 6.513 ± 0.094	6.729GluLeu: 6.729 ± 0.092	2.277GluMet: 2.277 ± 0.056	4.302GluAsn: 4.302 ± 0.066	2.002GluPro: 2.002 ± 0.043	3.207GluGln: 3.207 ± 0.068	3.254GluArg: 3.254 ± 0.058	3.823GluSer: 3.823 ± 0.083	4.03GluThr: 4.03 ± 0.081	3.928GluVal: 3.928 ± 0.07	0.815GluTrp: 0.815 ± 0.029	3.179GluTyr: 3.179 ± 0.058	0.0GluXaa: 0.0 ± 0.0
Phe	3.216PheAla: 3.216 ± 0.055	0.963PheCys: 0.963 ± 0.028	2.754PheAsp: 2.754 ± 0.05	2.823PheGlu: 2.823 ± 0.052	2.037PhePhe: 2.037 ± 0.045	2.929PheGly: 2.929 ± 0.049	0.916PheHis: 0.916 ± 0.028	2.573PheIle: 2.573 ± 0.055	1.89PheLys: 1.89 ± 0.049	4.052PheLeu: 4.052 ± 0.071	1.171PheMet: 1.171 ± 0.03	1.5PheAsn: 1.5 ± 0.036	1.327PhePro: 1.327 ± 0.032	1.316PheGln: 1.316 ± 0.032	1.615PheArg: 1.615 ± 0.035	3.03PheSer: 3.03 ± 0.056	2.392PheThr: 2.392 ± 0.048	2.962PheVal: 2.962 ± 0.055	0.518PheTrp: 0.518 ± 0.021	1.846PheTyr: 1.846 ± 0.045	0.0PheXaa: 0.0 ± 0.0
Gly	4.522GlyAla: 4.522 ± 0.078	1.356GlyCys: 1.356 ± 0.037	3.23GlyAsp: 3.23 ± 0.06	4.277GlyGlu: 4.277 ± 0.056	2.938GlyPhe: 2.938 ± 0.051	4.235GlyGly: 4.235 ± 0.078	1.264GlyHis: 1.264 ± 0.032	5.756GlyIle: 5.756 ± 0.065	4.976GlyLys: 4.976 ± 0.063	5.451GlyLeu: 5.451 ± 0.078	2.458GlyMet: 2.458 ± 0.048	2.889GlyAsn: 2.889 ± 0.049	1.182GlyPro: 1.182 ± 0.034	2.113GlyGln: 2.113 ± 0.042	2.838GlyArg: 2.838 ± 0.054	3.984GlySer: 3.984 ± 0.069	4.123GlyThr: 4.123 ± 0.075	4.678GlyVal: 4.678 ± 0.07	0.884GlyTrp: 0.884 ± 0.032	3.211GlyTyr: 3.211 ± 0.051	0.0GlyXaa: 0.0 ± 0.0
His	1.166HisAla: 1.166 ± 0.028	0.326HisCys: 0.326 ± 0.016	1.01HisAsp: 1.01 ± 0.033	1.202HisGlu: 1.202 ± 0.033	0.982HisPhe: 0.982 ± 0.028	1.191HisGly: 1.191 ± 0.034	0.484HisHis: 0.484 ± 0.029	1.32HisIle: 1.32 ± 0.032	0.923HisLys: 0.923 ± 0.026	1.557HisLeu: 1.557 ± 0.041	0.629HisMet: 0.629 ± 0.025	0.784HisAsn: 0.784 ± 0.026	0.882HisPro: 0.882 ± 0.027	0.559HisGln: 0.559 ± 0.023	0.794HisArg: 0.794 ± 0.024	1.012HisSer: 1.012 ± 0.029	1.047HisThr: 1.047 ± 0.033	1.218HisVal: 1.218 ± 0.034	0.261HisTrp: 0.261 ± 0.016	0.864HisTyr: 0.864 ± 0.025	0.0HisXaa: 0.0 ± 0.0
Ile	5.585IleAla: 5.585 ± 0.07	1.422IleCys: 1.422 ± 0.037	3.915IleAsp: 3.915 ± 0.061	4.684IleGlu: 4.684 ± 0.065	2.899IlePhe: 2.899 ± 0.053	4.693IleGly: 4.693 ± 0.066	1.325IleHis: 1.325 ± 0.032	4.584IleIle: 4.584 ± 0.081	3.792IleLys: 3.792 ± 0.055	6.602IleLeu: 6.602 ± 0.082	1.933IleMet: 1.933 ± 0.041	2.803IleAsn: 2.803 ± 0.044	2.947IlePro: 2.947 ± 0.06	2.38IleGln: 2.38 ± 0.049	3.539IleArg: 3.539 ± 0.053	4.925IleSer: 4.925 ± 0.075	4.065IleThr: 4.065 ± 0.064	4.75IleVal: 4.75 ± 0.074	0.77IleTrp: 0.77 ± 0.026	2.715IleTyr: 2.715 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	4.8LysAla: 4.8 ± 0.065	0.682LysCys: 0.682 ± 0.024	3.785LysAsp: 3.785 ± 0.06	6.701LysGlu: 6.701 ± 0.092	1.737LysPhe: 1.737 ± 0.038	3.865LysGly: 3.865 ± 0.057	1.027LysHis: 1.027 ± 0.028	4.42LysIle: 4.42 ± 0.065	6.665LysLys: 6.665 ± 0.098	5.339LysLeu: 5.339 ± 0.071	2.212LysMet: 2.212 ± 0.042	3.729LysAsn: 3.729 ± 0.055	1.984LysPro: 1.984 ± 0.044	2.804LysGln: 2.804 ± 0.05	3.23LysArg: 3.23 ± 0.052	3.42LysSer: 3.42 ± 0.062	3.985LysThr: 3.985 ± 0.063	3.672LysVal: 3.672 ± 0.055	0.69LysTrp: 0.69 ± 0.027	2.599LysTyr: 2.599 ± 0.063	0.0LysXaa: 0.0 ± 0.0
Leu	6.772LeuAla: 6.772 ± 0.088	1.621LeuCys: 1.621 ± 0.042	5.061LeuAsp: 5.061 ± 0.066	6.021LeuGlu: 6.021 ± 0.088	4.021LeuPhe: 4.021 ± 0.081	5.315LeuGly: 5.315 ± 0.079	1.625LeuHis: 1.625 ± 0.044	5.923LeuIle: 5.923 ± 0.087	5.58LeuLys: 5.58 ± 0.079	8.534LeuLeu: 8.534 ± 0.12	2.694LeuMet: 2.694 ± 0.048	3.744LeuAsn: 3.744 ± 0.057	3.479LeuPro: 3.479 ± 0.057	2.949LeuGln: 2.949 ± 0.059	3.638LeuArg: 3.638 ± 0.059	6.47LeuSer: 6.47 ± 0.076	5.399LeuThr: 5.399 ± 0.068	5.357LeuVal: 5.357 ± 0.07	0.898LeuTrp: 0.898 ± 0.026	3.725LeuTyr: 3.725 ± 0.057	0.0LeuXaa: 0.0 ± 0.0
Met	2.52MetAla: 2.52 ± 0.049	0.372MetCys: 0.372 ± 0.02	1.796MetAsp: 1.796 ± 0.039	2.538MetGlu: 2.538 ± 0.046	0.996MetPhe: 0.996 ± 0.034	1.875MetGly: 1.875 ± 0.04	0.469MetHis: 0.469 ± 0.02	2.332MetIle: 2.332 ± 0.052	2.431MetLys: 2.431 ± 0.045	2.753MetLeu: 2.753 ± 0.053	1.028MetMet: 1.028 ± 0.033	1.595MetAsn: 1.595 ± 0.041	1.179MetPro: 1.179 ± 0.031	1.206MetGln: 1.206 ± 0.031	1.447MetArg: 1.447 ± 0.04	1.712MetSer: 1.712 ± 0.041	1.88MetThr: 1.88 ± 0.038	1.907MetVal: 1.907 ± 0.041	0.3MetTrp: 0.3 ± 0.019	1.02MetTyr: 1.02 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.308AsnAla: 3.308 ± 0.055	0.694AsnCys: 0.694 ± 0.029	2.312AsnAsp: 2.312 ± 0.048	3.104AsnGlu: 3.104 ± 0.053	1.66AsnPhe: 1.66 ± 0.035	3.631AsnGly: 3.631 ± 0.072	0.844AsnHis: 0.844 ± 0.025	3.088AsnIle: 3.088 ± 0.049	2.555AsnLys: 2.555 ± 0.05	3.728AsnLeu: 3.728 ± 0.059	1.37AsnMet: 1.37 ± 0.029	1.809AsnAsn: 1.809 ± 0.047	1.92AsnPro: 1.92 ± 0.036	1.683AsnGln: 1.683 ± 0.037	2.006AsnArg: 2.006 ± 0.042	2.339AsnSer: 2.339 ± 0.041	2.499AsnThr: 2.499 ± 0.054	2.842AsnVal: 2.842 ± 0.051	0.583AsnTrp: 0.583 ± 0.027	1.83AsnTyr: 1.83 ± 0.043	0.0AsnXaa: 0.0 ± 0.0
Pro	2.313ProAla: 2.313 ± 0.056	0.472ProCys: 0.472 ± 0.022	2.379ProAsp: 2.379 ± 0.047	3.001ProGlu: 3.001 ± 0.058	1.613ProPhe: 1.613 ± 0.038	2.115ProGly: 2.115 ± 0.038	0.589ProHis: 0.589 ± 0.022	2.12ProIle: 2.12 ± 0.043	2.055ProLys: 2.055 ± 0.043	2.63ProLeu: 2.63 ± 0.048	0.903ProMet: 0.903 ± 0.027	1.278ProAsn: 1.278 ± 0.031	0.718ProPro: 0.718 ± 0.026	1.27ProGln: 1.27 ± 0.03	0.983ProArg: 0.983 ± 0.032	2.028ProSer: 2.028 ± 0.042	1.699ProThr: 1.699 ± 0.042	2.791ProVal: 2.791 ± 0.051	0.396ProTrp: 0.396 ± 0.017	1.525ProTyr: 1.525 ± 0.04	0.0ProXaa: 0.0 ± 0.0
Gln	2.824GlnAla: 2.824 ± 0.054	0.415GlnCys: 0.415 ± 0.023	1.736GlnAsp: 1.736 ± 0.042	2.779GlnGlu: 2.779 ± 0.059	1.314GlnPhe: 1.314 ± 0.033	1.866GlnGly: 1.866 ± 0.043	0.504GlnHis: 0.504 ± 0.021	2.912GlnIle: 2.912 ± 0.055	3.137GlnLys: 3.137 ± 0.053	3.264GlnLeu: 3.264 ± 0.056	1.425GlnMet: 1.425 ± 0.035	1.777GlnAsn: 1.777 ± 0.042	1.07GlnPro: 1.07 ± 0.029	1.392GlnGln: 1.392 ± 0.034	1.522GlnArg: 1.522 ± 0.038	1.939GlnSer: 1.939 ± 0.042	2.208GlnThr: 2.208 ± 0.052	2.097GlnVal: 2.097 ± 0.045	0.375GlnTrp: 0.375 ± 0.019	1.601GlnTyr: 1.601 ± 0.037	0.0GlnXaa: 0.0 ± 0.0
Arg	2.716ArgAla: 2.716 ± 0.048	0.61ArgCys: 0.61 ± 0.022	2.135ArgAsp: 2.135 ± 0.045	3.332ArgGlu: 3.332 ± 0.061	1.988ArgPhe: 1.988 ± 0.047	2.248ArgGly: 2.248 ± 0.05	0.796ArgHis: 0.796 ± 0.029	3.362ArgIle: 3.362 ± 0.06	3.343ArgLys: 3.343 ± 0.052	3.92ArgLeu: 3.92 ± 0.065	1.601ArgMet: 1.601 ± 0.037	1.93ArgAsn: 1.93 ± 0.043	1.363ArgPro: 1.363 ± 0.034	1.858ArgGln: 1.858 ± 0.043	2.178ArgArg: 2.178 ± 0.043	2.267ArgSer: 2.267 ± 0.043	2.161ArgThr: 2.161 ± 0.041	2.674ArgVal: 2.674 ± 0.053	0.448ArgTrp: 0.448 ± 0.019	1.991ArgTyr: 1.991 ± 0.045	0.0ArgXaa: 0.0 ± 0.0
Ser	4.401SerAla: 4.401 ± 0.069	0.962SerCys: 0.962 ± 0.028	3.691SerAsp: 3.691 ± 0.064	4.332SerGlu: 4.332 ± 0.089	2.999SerPhe: 2.999 ± 0.052	4.692SerGly: 4.692 ± 0.07	1.104SerHis: 1.104 ± 0.039	4.241SerIle: 4.241 ± 0.07	3.645SerLys: 3.645 ± 0.051	5.225SerLeu: 5.225 ± 0.077	1.934SerMet: 1.934 ± 0.041	2.358SerAsn: 2.358 ± 0.046	1.668SerPro: 1.668 ± 0.037	2.079SerGln: 2.079 ± 0.037	2.483SerArg: 2.483 ± 0.041	3.906SerSer: 3.906 ± 0.088	2.945SerThr: 2.945 ± 0.057	4.448SerVal: 4.448 ± 0.069	0.746SerTrp: 0.746 ± 0.028	2.756SerTyr: 2.756 ± 0.052	0.0SerXaa: 0.0 ± 0.0
Thr	4.631ThrAla: 4.631 ± 0.075	0.686ThrCys: 0.686 ± 0.022	3.41ThrAsp: 3.41 ± 0.058	3.717ThrGlu: 3.717 ± 0.069	2.36ThrPhe: 2.36 ± 0.054	4.38ThrGly: 4.38 ± 0.07	0.938ThrHis: 0.938 ± 0.031	4.093ThrIle: 4.093 ± 0.071	3.407ThrLys: 3.407 ± 0.053	4.926ThrLeu: 4.926 ± 0.072	1.527ThrMet: 1.527 ± 0.036	2.219ThrAsn: 2.219 ± 0.044	2.218ThrPro: 2.218 ± 0.051	1.972ThrGln: 1.972 ± 0.049	1.897ThrArg: 1.897 ± 0.044	3.179ThrSer: 3.179 ± 0.065	2.988ThrThr: 2.988 ± 0.079	4.414ThrVal: 4.414 ± 0.065	0.611ThrTrp: 0.611 ± 0.026	2.173ThrTyr: 2.173 ± 0.042	0.0ThrXaa: 0.0 ± 0.0
Val	4.466ValAla: 4.466 ± 0.076	1.306ValCys: 1.306 ± 0.037	3.487ValAsp: 3.487 ± 0.062	3.939ValGlu: 3.939 ± 0.069	2.972ValPhe: 2.972 ± 0.049	3.992ValGly: 3.992 ± 0.069	1.124ValHis: 1.124 ± 0.031	4.844ValIle: 4.844 ± 0.064	3.945ValLys: 3.945 ± 0.062	6.518ValLeu: 6.518 ± 0.09	2.043ValMet: 2.043 ± 0.046	2.862ValAsn: 2.862 ± 0.059	2.455ValPro: 2.455 ± 0.045	2.147ValGln: 2.147 ± 0.042	2.915ValArg: 2.915 ± 0.052	4.837ValSer: 4.837 ± 0.074	4.259ValThr: 4.259 ± 0.073	4.478ValVal: 4.478 ± 0.068	0.801ValTrp: 0.801 ± 0.027	2.854ValTyr: 2.854 ± 0.048	0.0ValXaa: 0.0 ± 0.0
Trp	0.642TrpAla: 0.642 ± 0.026	0.213TrpCys: 0.213 ± 0.012	0.64TrpAsp: 0.64 ± 0.023	0.757TrpGlu: 0.757 ± 0.026	0.49TrpPhe: 0.49 ± 0.02	0.812TrpGly: 0.812 ± 0.029	0.247TrpHis: 0.247 ± 0.016	0.784TrpIle: 0.784 ± 0.025	0.914TrpLys: 0.914 ± 0.029	1.057TrpLeu: 1.057 ± 0.036	0.371TrpMet: 0.371 ± 0.018	0.73TrpAsn: 0.73 ± 0.023	0.285TrpPro: 0.285 ± 0.016	0.491TrpGln: 0.491 ± 0.022	0.48TrpArg: 0.48 ± 0.023	0.665TrpSer: 0.665 ± 0.027	0.526TrpThr: 0.526 ± 0.022	0.575TrpVal: 0.575 ± 0.024	0.164TrpTrp: 0.164 ± 0.011	0.616TrpTyr: 0.616 ± 0.028	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.888TyrAla: 2.888 ± 0.045	0.686TyrCys: 0.686 ± 0.025	2.655TyrAsp: 2.655 ± 0.055	3.143TyrGlu: 3.143 ± 0.058	1.92TyrPhe: 1.92 ± 0.044	2.984TyrGly: 2.984 ± 0.047	0.947TyrHis: 0.947 ± 0.025	2.685TyrIle: 2.685 ± 0.05	2.2TyrLys: 2.2 ± 0.043	4.055TyrLeu: 4.055 ± 0.067	1.122TyrMet: 1.122 ± 0.033	1.895TyrAsn: 1.895 ± 0.044	1.593TyrPro: 1.593 ± 0.039	1.744TyrGln: 1.744 ± 0.042	2.206TyrArg: 2.206 ± 0.042	2.496TyrSer: 2.496 ± 0.048	2.461TyrThr: 2.461 ± 0.05	2.638TyrVal: 2.638 ± 0.052	0.529TyrTrp: 0.529 ± 0.02	2.195TyrTyr: 2.195 ± 0.052	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3669 proteins (1184311 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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