Amino acid dipepetide frequency for Chryseolinea serpens

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.737AlaAla: 6.737 ± 0.061	0.77AlaCys: 0.77 ± 0.021	4.333AlaAsp: 4.333 ± 0.045	4.26AlaGlu: 4.26 ± 0.05	3.935AlaPhe: 3.935 ± 0.047	5.951AlaGly: 5.951 ± 0.057	1.423AlaHis: 1.423 ± 0.023	4.999AlaIle: 4.999 ± 0.049	4.3AlaLys: 4.3 ± 0.055	8.34AlaLeu: 8.34 ± 0.076	1.973AlaMet: 1.973 ± 0.031	3.32AlaAsn: 3.32 ± 0.037	2.888AlaPro: 2.888 ± 0.036	3.049AlaGln: 3.049 ± 0.039	3.294AlaArg: 3.294 ± 0.037	5.112AlaSer: 5.112 ± 0.044	4.898AlaThr: 4.898 ± 0.063	5.298AlaVal: 5.298 ± 0.059	1.088AlaTrp: 1.088 ± 0.02	2.889AlaTyr: 2.889 ± 0.037	0.0AlaXaa: 0.0 ± 0.0
Cys	0.57CysAla: 0.57 ± 0.016	0.122CysCys: 0.122 ± 0.007	0.374CysAsp: 0.374 ± 0.013	0.384CysGlu: 0.384 ± 0.014	0.389CysPhe: 0.389 ± 0.014	0.604CysGly: 0.604 ± 0.018	0.23CysHis: 0.23 ± 0.012	0.504CysIle: 0.504 ± 0.015	0.333CysLys: 0.333 ± 0.012	0.8CysLeu: 0.8 ± 0.017	0.177CysMet: 0.177 ± 0.01	0.316CysAsn: 0.316 ± 0.012	0.343CysPro: 0.343 ± 0.014	0.261CysGln: 0.261 ± 0.01	0.338CysArg: 0.338 ± 0.011	0.564CysSer: 0.564 ± 0.02	0.44CysThr: 0.44 ± 0.015	0.494CysVal: 0.494 ± 0.017	0.089CysTrp: 0.089 ± 0.006	0.285CysTyr: 0.285 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	4.386AspAla: 4.386 ± 0.055	0.331AspCys: 0.331 ± 0.014	2.86AspAsp: 2.86 ± 0.04	3.241AspGlu: 3.241 ± 0.038	3.148AspPhe: 3.148 ± 0.04	4.21AspGly: 4.21 ± 0.06	1.276AspHis: 1.276 ± 0.02	3.457AspIle: 3.457 ± 0.038	3.485AspLys: 3.485 ± 0.05	5.156AspLeu: 5.156 ± 0.054	1.178AspMet: 1.178 ± 0.024	2.509AspAsn: 2.509 ± 0.039	2.566AspPro: 2.566 ± 0.035	1.943AspGln: 1.943 ± 0.028	2.523AspArg: 2.523 ± 0.031	2.821AspSer: 2.821 ± 0.042	2.576AspThr: 2.576 ± 0.034	3.848AspVal: 3.848 ± 0.037	0.759AspTrp: 0.759 ± 0.019	2.359AspTyr: 2.359 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	4.525GluAla: 4.525 ± 0.05	0.299GluCys: 0.299 ± 0.013	2.756GluAsp: 2.756 ± 0.04	3.711GluGlu: 3.711 ± 0.05	2.479GluPhe: 2.479 ± 0.032	3.692GluGly: 3.692 ± 0.037	1.189GluHis: 1.189 ± 0.021	3.924GluIle: 3.924 ± 0.044	4.811GluLys: 4.811 ± 0.056	5.124GluLeu: 5.124 ± 0.057	1.51GluMet: 1.51 ± 0.025	2.923GluAsn: 2.923 ± 0.035	1.839GluPro: 1.839 ± 0.026	2.257GluGln: 2.257 ± 0.038	2.78GluArg: 2.78 ± 0.039	3.016GluSer: 3.016 ± 0.035	3.147GluThr: 3.147 ± 0.035	3.979GluVal: 3.979 ± 0.042	0.731GluTrp: 0.731 ± 0.018	2.033GluTyr: 2.033 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	3.533PheAla: 3.533 ± 0.038	0.456PheCys: 0.456 ± 0.014	3.027PheAsp: 3.027 ± 0.041	2.754PheGlu: 2.754 ± 0.04	2.639PhePhe: 2.639 ± 0.039	3.43PheGly: 3.43 ± 0.041	1.07PheHis: 1.07 ± 0.019	3.146PheIle: 3.146 ± 0.042	2.866PheLys: 2.866 ± 0.036	4.665PheLeu: 4.665 ± 0.051	1.15PheMet: 1.15 ± 0.02	2.566PheAsn: 2.566 ± 0.036	1.891PhePro: 1.891 ± 0.026	1.738PheGln: 1.738 ± 0.027	2.21PheArg: 2.21 ± 0.032	3.697PheSer: 3.697 ± 0.043	3.205PheThr: 3.205 ± 0.054	3.403PheVal: 3.403 ± 0.045	0.611PheTrp: 0.611 ± 0.016	2.07PheTyr: 2.07 ± 0.034	0.0PheXaa: 0.0 ± 0.0
Gly	5.047GlyAla: 5.047 ± 0.052	0.652GlyCys: 0.652 ± 0.019	3.742GlyAsp: 3.742 ± 0.048	3.578GlyGlu: 3.578 ± 0.04	3.61GlyPhe: 3.61 ± 0.036	5.117GlyGly: 5.117 ± 0.074	1.379GlyHis: 1.379 ± 0.025	4.668GlyIle: 4.668 ± 0.046	5.11GlyLys: 5.11 ± 0.06	6.633GlyLeu: 6.633 ± 0.059	1.812GlyMet: 1.812 ± 0.026	3.493GlyAsn: 3.493 ± 0.053	1.992GlyPro: 1.992 ± 0.032	2.413GlyGln: 2.413 ± 0.034	2.908GlyArg: 2.908 ± 0.039	4.354GlySer: 4.354 ± 0.057	4.655GlyThr: 4.655 ± 0.087	5.094GlyVal: 5.094 ± 0.045	1.088GlyTrp: 1.088 ± 0.023	2.955GlyTyr: 2.955 ± 0.044	0.0GlyXaa: 0.0 ± 0.0
His	1.583HisAla: 1.583 ± 0.023	0.179HisCys: 0.179 ± 0.009	1.144HisAsp: 1.144 ± 0.023	1.176HisGlu: 1.176 ± 0.021	1.152HisPhe: 1.152 ± 0.022	1.395HisGly: 1.395 ± 0.025	0.695HisHis: 0.695 ± 0.018	1.225HisIle: 1.225 ± 0.023	0.95HisLys: 0.95 ± 0.02	1.962HisLeu: 1.962 ± 0.031	0.43HisMet: 0.43 ± 0.012	0.789HisAsn: 0.789 ± 0.02	1.195HisPro: 1.195 ± 0.023	0.825HisGln: 0.825 ± 0.019	0.989HisArg: 0.989 ± 0.021	1.136HisSer: 1.136 ± 0.022	1.147HisThr: 1.147 ± 0.023	1.28HisVal: 1.28 ± 0.026	0.33HisTrp: 0.33 ± 0.013	0.984HisTyr: 0.984 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	5.315IleAla: 5.315 ± 0.052	0.547IleCys: 0.547 ± 0.018	3.77IleAsp: 3.77 ± 0.039	3.635IleGlu: 3.635 ± 0.042	3.02IlePhe: 3.02 ± 0.048	4.427IleGly: 4.427 ± 0.045	1.347IleHis: 1.347 ± 0.027	3.673IleIle: 3.673 ± 0.044	3.647IleLys: 3.647 ± 0.039	5.709IleLeu: 5.709 ± 0.052	1.191IleMet: 1.191 ± 0.021	3.002IleAsn: 3.002 ± 0.04	2.876IlePro: 2.876 ± 0.039	2.242IleGln: 2.242 ± 0.031	3.097IleArg: 3.097 ± 0.039	4.117IleSer: 4.117 ± 0.042	4.289IleThr: 4.289 ± 0.046	4.343IleVal: 4.343 ± 0.045	0.606IleTrp: 0.606 ± 0.018	2.118IleTyr: 2.118 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	5.016LysAla: 5.016 ± 0.057	0.27LysCys: 0.27 ± 0.011	3.862LysAsp: 3.862 ± 0.045	4.352LysGlu: 4.352 ± 0.049	2.54LysPhe: 2.54 ± 0.034	4.202LysGly: 4.202 ± 0.045	1.187LysHis: 1.187 ± 0.02	4.294LysIle: 4.294 ± 0.049	4.997LysLys: 4.997 ± 0.064	5.502LysLeu: 5.502 ± 0.05	1.728LysMet: 1.728 ± 0.027	3.42LysAsn: 3.42 ± 0.035	2.609LysPro: 2.609 ± 0.033	2.161LysGln: 2.161 ± 0.03	2.85LysArg: 2.85 ± 0.034	3.514LysSer: 3.514 ± 0.043	3.97LysThr: 3.97 ± 0.041	4.24LysVal: 4.24 ± 0.045	0.669LysTrp: 0.669 ± 0.019	2.277LysTyr: 2.277 ± 0.031	0.0LysXaa: 0.0 ± 0.0
Leu	7.618LeuAla: 7.618 ± 0.063	0.817LeuCys: 0.817 ± 0.02	4.89LeuAsp: 4.89 ± 0.05	5.159LeuGlu: 5.159 ± 0.061	4.687LeuPhe: 4.687 ± 0.049	6.214LeuGly: 6.214 ± 0.059	1.937LeuHis: 1.937 ± 0.028	5.677LeuIle: 5.677 ± 0.061	6.654LeuLys: 6.654 ± 0.053	9.585LeuLeu: 9.585 ± 0.081	2.168LeuMet: 2.168 ± 0.027	4.545LeuAsn: 4.545 ± 0.045	4.248LeuPro: 4.248 ± 0.046	3.774LeuGln: 3.774 ± 0.045	4.482LeuArg: 4.482 ± 0.046	6.952LeuSer: 6.952 ± 0.058	5.865LeuThr: 5.865 ± 0.055	6.274LeuVal: 6.274 ± 0.058	1.125LeuTrp: 1.125 ± 0.024	3.444LeuTyr: 3.444 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	2.02MetAla: 2.02 ± 0.03	0.125MetCys: 0.125 ± 0.007	1.191MetAsp: 1.191 ± 0.023	1.429MetGlu: 1.429 ± 0.026	0.846MetPhe: 0.846 ± 0.018	1.591MetGly: 1.591 ± 0.025	0.455MetHis: 0.455 ± 0.013	1.451MetIle: 1.451 ± 0.024	2.059MetLys: 2.059 ± 0.029	2.217MetLeu: 2.217 ± 0.028	0.594MetMet: 0.594 ± 0.017	1.224MetAsn: 1.224 ± 0.022	1.082MetPro: 1.082 ± 0.023	0.812MetGln: 0.812 ± 0.018	1.132MetArg: 1.132 ± 0.021	1.257MetSer: 1.257 ± 0.022	1.362MetThr: 1.362 ± 0.027	1.535MetVal: 1.535 ± 0.021	0.198MetTrp: 0.198 ± 0.009	0.581MetTyr: 0.581 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.782AsnAla: 3.782 ± 0.043	0.29AsnCys: 0.29 ± 0.014	2.61AsnAsp: 2.61 ± 0.047	2.508AsnGlu: 2.508 ± 0.033	2.503AsnPhe: 2.503 ± 0.033	3.732AsnGly: 3.732 ± 0.052	0.914AsnHis: 0.914 ± 0.02	3.071AsnIle: 3.071 ± 0.034	2.584AsnLys: 2.584 ± 0.032	4.567AsnLeu: 4.567 ± 0.047	0.972AsnMet: 0.972 ± 0.021	2.418AsnAsn: 2.418 ± 0.046	2.591AsnPro: 2.591 ± 0.04	1.684AsnGln: 1.684 ± 0.032	2.132AsnArg: 2.132 ± 0.03	2.641AsnSer: 2.641 ± 0.034	3.005AsnThr: 3.005 ± 0.043	3.167AsnVal: 3.167 ± 0.045	0.575AsnTrp: 0.575 ± 0.016	2.039AsnTyr: 2.039 ± 0.029	0.0AsnXaa: 0.0 ± 0.0
Pro	3.642ProAla: 3.642 ± 0.046	0.238ProCys: 0.238 ± 0.009	2.763ProAsp: 2.763 ± 0.034	2.981ProGlu: 2.981 ± 0.039	2.086ProPhe: 2.086 ± 0.033	3.23ProGly: 3.23 ± 0.04	0.845ProHis: 0.845 ± 0.017	2.228ProIle: 2.228 ± 0.029	2.111ProLys: 2.111 ± 0.032	3.69ProLeu: 3.69 ± 0.041	0.895ProMet: 0.895 ± 0.021	1.811ProAsn: 1.811 ± 0.032	1.527ProPro: 1.527 ± 0.033	1.469ProGln: 1.469 ± 0.021	1.47ProArg: 1.47 ± 0.024	2.629ProSer: 2.629 ± 0.034	2.376ProThr: 2.376 ± 0.045	3.48ProVal: 3.48 ± 0.044	0.539ProTrp: 0.539 ± 0.016	1.559ProTyr: 1.559 ± 0.029	0.0ProXaa: 0.0 ± 0.0
Gln	2.91GlnAla: 2.91 ± 0.036	0.219GlnCys: 0.219 ± 0.009	1.709GlnAsp: 1.709 ± 0.03	2.088GlnGlu: 2.088 ± 0.036	1.685GlnPhe: 1.685 ± 0.03	2.36GlnGly: 2.36 ± 0.03	0.875GlnHis: 0.875 ± 0.019	2.003GlnIle: 2.003 ± 0.028	2.437GlnLys: 2.437 ± 0.036	3.447GlnLeu: 3.447 ± 0.04	0.817GlnMet: 0.817 ± 0.019	1.783GlnAsn: 1.783 ± 0.025	1.64GlnPro: 1.64 ± 0.029	1.819GlnGln: 1.819 ± 0.036	1.913GlnArg: 1.913 ± 0.033	2.179GlnSer: 2.179 ± 0.031	2.165GlnThr: 2.165 ± 0.034	2.457GlnVal: 2.457 ± 0.034	0.587GlnTrp: 0.587 ± 0.016	1.522GlnTyr: 1.522 ± 0.025	0.0GlnXaa: 0.0 ± 0.0
Arg	3.094ArgAla: 3.094 ± 0.037	0.283ArgCys: 0.283 ± 0.012	2.431ArgAsp: 2.431 ± 0.034	2.883ArgGlu: 2.883 ± 0.039	2.353ArgPhe: 2.353 ± 0.034	2.476ArgGly: 2.476 ± 0.038	0.931ArgHis: 0.931 ± 0.019	3.267ArgIle: 3.267 ± 0.036	3.235ArgLys: 3.235 ± 0.039	4.302ArgLeu: 4.302 ± 0.047	1.256ArgMet: 1.256 ± 0.023	2.282ArgAsn: 2.282 ± 0.033	1.629ArgPro: 1.629 ± 0.027	1.776ArgGln: 1.776 ± 0.029	2.022ArgArg: 2.022 ± 0.032	2.72ArgSer: 2.72 ± 0.035	2.405ArgThr: 2.405 ± 0.035	2.926ArgVal: 2.926 ± 0.038	0.666ArgTrp: 0.666 ± 0.018	1.957ArgTyr: 1.957 ± 0.027	0.0ArgXaa: 0.0 ± 0.0
Ser	4.749SerAla: 4.749 ± 0.047	0.552SerCys: 0.552 ± 0.016	3.219SerAsp: 3.219 ± 0.032	3.064SerGlu: 3.064 ± 0.039	3.559SerPhe: 3.559 ± 0.039	4.874SerGly: 4.874 ± 0.054	1.233SerHis: 1.233 ± 0.022	4.199SerIle: 4.199 ± 0.04	3.456SerLys: 3.456 ± 0.044	6.523SerLeu: 6.523 ± 0.048	1.414SerMet: 1.414 ± 0.024	2.733SerAsn: 2.733 ± 0.034	2.687SerPro: 2.687 ± 0.038	2.1SerGln: 2.1 ± 0.032	2.702SerArg: 2.702 ± 0.033	3.952SerSer: 3.952 ± 0.052	3.741SerThr: 3.741 ± 0.048	4.461SerVal: 4.461 ± 0.043	0.821SerTrp: 0.821 ± 0.019	2.459SerTyr: 2.459 ± 0.036	0.0SerXaa: 0.0 ± 0.0
Thr	4.99ThrAla: 4.99 ± 0.066	0.424ThrCys: 0.424 ± 0.023	3.321ThrAsp: 3.321 ± 0.048	3.045ThrGlu: 3.045 ± 0.037	3.21ThrPhe: 3.21 ± 0.05	4.838ThrGly: 4.838 ± 0.065	1.13ThrHis: 1.13 ± 0.021	3.836ThrIle: 3.836 ± 0.054	3.089ThrLys: 3.089 ± 0.035	6.423ThrLeu: 6.423 ± 0.054	1.064ThrMet: 1.064 ± 0.02	2.59ThrAsn: 2.59 ± 0.046	3.079ThrPro: 3.079 ± 0.042	2.034ThrGln: 2.034 ± 0.031	2.447ThrArg: 2.447 ± 0.031	3.77ThrSer: 3.77 ± 0.048	3.925ThrThr: 3.925 ± 0.056	4.503ThrVal: 4.503 ± 0.062	0.83ThrTrp: 0.83 ± 0.022	2.427ThrTyr: 2.427 ± 0.037	0.0ThrXaa: 0.0 ± 0.0
Val	5.503ValAla: 5.503 ± 0.059	0.61ValCys: 0.61 ± 0.017	3.68ValAsp: 3.68 ± 0.032	3.742ValGlu: 3.742 ± 0.038	3.399ValPhe: 3.399 ± 0.042	4.43ValGly: 4.43 ± 0.044	1.273ValHis: 1.273 ± 0.025	4.521ValIle: 4.521 ± 0.041	4.39ValLys: 4.39 ± 0.043	6.663ValLeu: 6.663 ± 0.055	1.712ValMet: 1.712 ± 0.027	3.457ValAsn: 3.457 ± 0.044	2.813ValPro: 2.813 ± 0.033	2.219ValGln: 2.219 ± 0.033	2.971ValArg: 2.971 ± 0.036	4.708ValSer: 4.708 ± 0.049	4.506ValThr: 4.506 ± 0.064	5.281ValVal: 5.281 ± 0.056	0.841ValTrp: 0.841 ± 0.02	2.526ValTyr: 2.526 ± 0.035	0.0ValXaa: 0.0 ± 0.0
Trp	0.858TrpAla: 0.858 ± 0.019	0.12TrpCys: 0.12 ± 0.006	0.67TrpAsp: 0.67 ± 0.019	0.688TrpGlu: 0.688 ± 0.015	0.605TrpPhe: 0.605 ± 0.017	0.868TrpGly: 0.868 ± 0.022	0.291TrpHis: 0.291 ± 0.011	0.836TrpIle: 0.836 ± 0.021	0.903TrpLys: 0.903 ± 0.02	1.227TrpLeu: 1.227 ± 0.024	0.403TrpMet: 0.403 ± 0.014	0.676TrpAsn: 0.676 ± 0.017	0.411TrpPro: 0.411 ± 0.013	0.542TrpGln: 0.542 ± 0.017	0.641TrpArg: 0.641 ± 0.015	0.834TrpSer: 0.834 ± 0.018	0.815TrpThr: 0.815 ± 0.021	0.825TrpVal: 0.825 ± 0.017	0.24TrpTrp: 0.24 ± 0.01	0.485TrpTyr: 0.485 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.98TyrAla: 2.98 ± 0.036	0.315TyrCys: 0.315 ± 0.012	2.277TyrAsp: 2.277 ± 0.034	2.048TyrGlu: 2.048 ± 0.03	2.279TyrPhe: 2.279 ± 0.034	2.66TyrGly: 2.66 ± 0.038	0.888TyrHis: 0.888 ± 0.019	1.988TyrIle: 1.988 ± 0.031	2.242TyrLys: 2.242 ± 0.032	3.583TyrLeu: 3.583 ± 0.041	0.716TyrMet: 0.716 ± 0.018	1.928TyrAsn: 1.928 ± 0.03	1.662TyrPro: 1.662 ± 0.027	1.498TyrGln: 1.498 ± 0.028	1.996TyrArg: 1.996 ± 0.032	2.523TyrSer: 2.523 ± 0.035	2.483TyrThr: 2.483 ± 0.041	2.359TyrVal: 2.359 ± 0.031	0.546TyrTrp: 0.546 ± 0.016	1.779TyrTyr: 1.779 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 6790 proteins (2474512 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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