Amino acid dipepetide frequency for Siccibacter turicensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.592AlaAla: 11.592 ± 0.144	1.162AlaCys: 1.162 ± 0.037	5.248AlaAsp: 5.248 ± 0.077	5.47AlaGlu: 5.47 ± 0.075	3.82AlaPhe: 3.82 ± 0.064	8.385AlaGly: 8.385 ± 0.108	2.061AlaHis: 2.061 ± 0.043	5.757AlaIle: 5.757 ± 0.081	3.476AlaLys: 3.476 ± 0.07	13.006AlaLeu: 13.006 ± 0.133	3.085AlaMet: 3.085 ± 0.054	2.979AlaAsn: 2.979 ± 0.053	4.151AlaPro: 4.151 ± 0.075	4.941AlaGln: 4.941 ± 0.078	6.536AlaArg: 6.536 ± 0.101	5.901AlaSer: 5.901 ± 0.088	5.236AlaThr: 5.236 ± 0.081	7.269AlaVal: 7.269 ± 0.088	1.865AlaTrp: 1.865 ± 0.044	1.962AlaTyr: 1.962 ± 0.039	0.0AlaXaa: 0.0 ± 0.0
Cys	1.011CysAla: 1.011 ± 0.033	0.169CysCys: 0.169 ± 0.011	0.612CysAsp: 0.612 ± 0.02	0.601CysGlu: 0.601 ± 0.021	0.436CysPhe: 0.436 ± 0.018	1.003CysGly: 1.003 ± 0.029	0.302CysHis: 0.302 ± 0.017	0.539CysIle: 0.539 ± 0.025	0.272CysLys: 0.272 ± 0.017	0.944CysLeu: 0.944 ± 0.027	0.232CysMet: 0.232 ± 0.015	0.302CysAsn: 0.302 ± 0.016	0.514CysPro: 0.514 ± 0.023	0.439CysGln: 0.439 ± 0.02	0.64CysArg: 0.64 ± 0.022	0.601CysSer: 0.601 ± 0.025	0.491CysThr: 0.491 ± 0.019	0.728CysVal: 0.728 ± 0.025	0.182CysTrp: 0.182 ± 0.012	0.316CysTyr: 0.316 ± 0.018	0.0CysXaa: 0.0 ± 0.0
Asp	6.052AspAla: 6.052 ± 0.072	0.489AspCys: 0.489 ± 0.02	3.244AspAsp: 3.244 ± 0.064	3.697AspGlu: 3.697 ± 0.074	2.007AspPhe: 2.007 ± 0.042	4.158AspGly: 4.158 ± 0.079	1.008AspHis: 1.008 ± 0.032	3.295AspIle: 3.295 ± 0.061	2.308AspLys: 2.308 ± 0.048	4.725AspLeu: 4.725 ± 0.069	1.336AspMet: 1.336 ± 0.033	2.168AspAsn: 2.168 ± 0.052	2.399AspPro: 2.399 ± 0.047	1.587AspGln: 1.587 ± 0.04	3.002AspArg: 3.002 ± 0.054	2.777AspSer: 2.777 ± 0.045	2.813AspThr: 2.813 ± 0.046	4.002AspVal: 4.002 ± 0.059	0.817AspTrp: 0.817 ± 0.027	1.838AspTyr: 1.838 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	5.836GluAla: 5.836 ± 0.083	0.431GluCys: 0.431 ± 0.02	2.315GluAsp: 2.315 ± 0.046	3.213GluGlu: 3.213 ± 0.066	1.691GluPhe: 1.691 ± 0.038	3.608GluGly: 3.608 ± 0.062	1.372GluHis: 1.372 ± 0.036	3.077GluIle: 3.077 ± 0.057	2.966GluLys: 2.966 ± 0.067	5.632GluLeu: 5.632 ± 0.087	1.82GluMet: 1.82 ± 0.041	2.119GluAsn: 2.119 ± 0.034	2.228GluPro: 2.228 ± 0.045	3.419GluGln: 3.419 ± 0.062	3.77GluArg: 3.77 ± 0.062	2.823GluSer: 2.823 ± 0.051	2.907GluThr: 2.907 ± 0.053	3.735GluVal: 3.735 ± 0.069	0.766GluTrp: 0.766 ± 0.024	1.386GluTyr: 1.386 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	3.736PheAla: 3.736 ± 0.055	0.498PheCys: 0.498 ± 0.018	2.351PheAsp: 2.351 ± 0.047	1.682PheGlu: 1.682 ± 0.035	1.583PhePhe: 1.583 ± 0.049	3.16PheGly: 3.16 ± 0.052	0.813PheHis: 0.813 ± 0.029	2.419PheIle: 2.419 ± 0.055	1.138PheLys: 1.138 ± 0.033	3.081PheLeu: 3.081 ± 0.055	0.99PheMet: 0.99 ± 0.033	1.642PheAsn: 1.642 ± 0.041	1.546PhePro: 1.546 ± 0.033	1.124PheGln: 1.124 ± 0.032	1.928PheArg: 1.928 ± 0.04	2.951PheSer: 2.951 ± 0.054	2.507PheThr: 2.507 ± 0.047	2.415PheVal: 2.415 ± 0.045	0.622PheTrp: 0.622 ± 0.026	1.179PheTyr: 1.179 ± 0.031	0.0PheXaa: 0.0 ± 0.0
Gly	6.791GlyAla: 6.791 ± 0.1	1.007GlyCys: 1.007 ± 0.034	4.008GlyAsp: 4.008 ± 0.064	4.744GlyGlu: 4.744 ± 0.07	3.224GlyPhe: 3.224 ± 0.054	5.684GlyGly: 5.684 ± 0.122	1.647GlyHis: 1.647 ± 0.044	4.84GlyIle: 4.84 ± 0.082	3.715GlyLys: 3.715 ± 0.071	7.702GlyLeu: 7.702 ± 0.093	2.441GlyMet: 2.441 ± 0.051	2.774GlyAsn: 2.774 ± 0.071	2.204GlyPro: 2.204 ± 0.049	3.016GlyGln: 3.016 ± 0.056	4.005GlyArg: 4.005 ± 0.063	4.386GlySer: 4.386 ± 0.082	4.026GlyThr: 4.026 ± 0.09	6.103GlyVal: 6.103 ± 0.077	1.322GlyTrp: 1.322 ± 0.035	2.587GlyTyr: 2.587 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.143HisAla: 2.143 ± 0.043	0.317HisCys: 0.317 ± 0.018	1.274HisAsp: 1.274 ± 0.037	1.099HisGlu: 1.099 ± 0.032	1.06HisPhe: 1.06 ± 0.031	1.752HisGly: 1.752 ± 0.039	0.799HisHis: 0.799 ± 0.027	1.277HisIle: 1.277 ± 0.035	0.726HisLys: 0.726 ± 0.026	2.31HisLeu: 2.31 ± 0.048	0.507HisMet: 0.507 ± 0.02	0.824HisAsn: 0.824 ± 0.025	1.351HisPro: 1.351 ± 0.036	1.157HisGln: 1.157 ± 0.036	1.306HisArg: 1.306 ± 0.034	1.233HisSer: 1.233 ± 0.031	1.186HisThr: 1.186 ± 0.03	1.294HisVal: 1.294 ± 0.031	0.391HisTrp: 0.391 ± 0.018	0.869HisTyr: 0.869 ± 0.027	0.0HisXaa: 0.0 ± 0.0
Ile	6.38IleAla: 6.38 ± 0.078	0.604IleCys: 0.604 ± 0.021	3.544IleAsp: 3.544 ± 0.057	3.066IleGlu: 3.066 ± 0.054	1.856IlePhe: 1.856 ± 0.042	4.56IleGly: 4.56 ± 0.084	1.129IleHis: 1.129 ± 0.035	2.957IleIle: 2.957 ± 0.063	2.033IleLys: 2.033 ± 0.041	4.549IleLeu: 4.549 ± 0.067	1.13IleMet: 1.13 ± 0.031	2.429IleAsn: 2.429 ± 0.048	2.556IlePro: 2.556 ± 0.045	1.643IleGln: 1.643 ± 0.041	2.884IleArg: 2.884 ± 0.057	3.382IleSer: 3.382 ± 0.06	3.502IleThr: 3.502 ± 0.061	3.862IleVal: 3.862 ± 0.068	0.635IleTrp: 0.635 ± 0.022	1.379IleTyr: 1.379 ± 0.033	0.0IleXaa: 0.0 ± 0.0
Lys	4.133LysAla: 4.133 ± 0.077	0.234LysCys: 0.234 ± 0.015	1.826LysAsp: 1.826 ± 0.041	2.2LysGlu: 2.2 ± 0.052	1.031LysPhe: 1.031 ± 0.029	2.827LysGly: 2.827 ± 0.052	0.799LysHis: 0.799 ± 0.03	2.015LysIle: 2.015 ± 0.042	1.932LysLys: 1.932 ± 0.049	3.808LysLeu: 3.808 ± 0.07	1.098LysMet: 1.098 ± 0.031	1.472LysAsn: 1.472 ± 0.036	2.002LysPro: 2.002 ± 0.044	1.765LysGln: 1.765 ± 0.038	2.425LysArg: 2.425 ± 0.045	2.1LysSer: 2.1 ± 0.049	2.309LysThr: 2.309 ± 0.04	2.747LysVal: 2.747 ± 0.053	0.434LysTrp: 0.434 ± 0.015	0.985LysTyr: 0.985 ± 0.032	0.0LysXaa: 0.0 ± 0.0
Leu	12.051LeuAla: 12.051 ± 0.119	1.279LeuCys: 1.279 ± 0.033	5.616LeuAsp: 5.616 ± 0.072	5.494LeuGlu: 5.494 ± 0.089	4.216LeuPhe: 4.216 ± 0.069	7.4LeuGly: 7.4 ± 0.099	2.384LeuHis: 2.384 ± 0.047	5.54LeuIle: 5.54 ± 0.081	4.217LeuLys: 4.217 ± 0.064	12.01LeuLeu: 12.01 ± 0.16	2.961LeuMet: 2.961 ± 0.049	4.182LeuAsn: 4.182 ± 0.063	5.856LeuPro: 5.856 ± 0.08	3.811LeuGln: 3.811 ± 0.065	6.599LeuArg: 6.599 ± 0.097	7.088LeuSer: 7.088 ± 0.085	6.606LeuThr: 6.606 ± 0.076	7.315LeuVal: 7.315 ± 0.097	1.486LeuTrp: 1.486 ± 0.039	2.563LeuTyr: 2.563 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	2.888MetAla: 2.888 ± 0.048	0.194MetCys: 0.194 ± 0.011	1.213MetAsp: 1.213 ± 0.028	1.269MetGlu: 1.269 ± 0.038	0.812MetPhe: 0.812 ± 0.027	1.797MetGly: 1.797 ± 0.042	0.538MetHis: 0.538 ± 0.022	1.381MetIle: 1.381 ± 0.041	1.358MetLys: 1.358 ± 0.036	3.177MetLeu: 3.177 ± 0.062	0.871MetMet: 0.871 ± 0.025	1.019MetAsn: 1.019 ± 0.032	1.406MetPro: 1.406 ± 0.034	1.206MetGln: 1.206 ± 0.033	1.518MetArg: 1.518 ± 0.037	1.818MetSer: 1.818 ± 0.034	1.774MetThr: 1.774 ± 0.035	2.027MetVal: 2.027 ± 0.046	0.261MetTrp: 0.261 ± 0.015	0.515MetTyr: 0.515 ± 0.02	0.0MetXaa: 0.0 ± 0.0
Asn	3.687AsnAla: 3.687 ± 0.076	0.302AsnCys: 0.302 ± 0.016	2.081AsnAsp: 2.081 ± 0.045	1.822AsnGlu: 1.822 ± 0.042	1.191AsnPhe: 1.191 ± 0.034	3.011AsnGly: 3.011 ± 0.068	0.801AsnHis: 0.801 ± 0.024	2.029AsnIle: 2.029 ± 0.042	1.348AsnLys: 1.348 ± 0.032	3.358AsnLeu: 3.358 ± 0.053	0.82AsnMet: 0.82 ± 0.025	1.463AsnAsn: 1.463 ± 0.044	2.117AsnPro: 2.117 ± 0.038	1.497AsnGln: 1.497 ± 0.033	2.068AsnArg: 2.068 ± 0.039	1.809AsnSer: 1.809 ± 0.047	1.886AsnThr: 1.886 ± 0.046	2.551AsnVal: 2.551 ± 0.059	0.543AsnTrp: 0.543 ± 0.024	1.091AsnTyr: 1.091 ± 0.037	0.0AsnXaa: 0.0 ± 0.0
Pro	5.122ProAla: 5.122 ± 0.082	0.386ProCys: 0.386 ± 0.019	3.076ProAsp: 3.076 ± 0.05	3.391ProGlu: 3.391 ± 0.053	1.847ProPhe: 1.847 ± 0.04	3.839ProGly: 3.839 ± 0.063	1.13ProHis: 1.13 ± 0.032	1.676ProIle: 1.676 ± 0.039	1.431ProLys: 1.431 ± 0.039	5.276ProLeu: 5.276 ± 0.084	1.097ProMet: 1.097 ± 0.029	1.221ProAsn: 1.221 ± 0.032	1.866ProPro: 1.866 ± 0.05	2.261ProGln: 2.261 ± 0.041	2.194ProArg: 2.194 ± 0.047	2.14ProSer: 2.14 ± 0.039	2.231ProThr: 2.231 ± 0.05	4.139ProVal: 4.139 ± 0.061	0.834ProTrp: 0.834 ± 0.028	1.168ProTyr: 1.168 ± 0.035	0.0ProXaa: 0.0 ± 0.0
Gln	4.972GlnAla: 4.972 ± 0.068	0.351GlnCys: 0.351 ± 0.017	1.832GlnAsp: 1.832 ± 0.039	2.107GlnGlu: 2.107 ± 0.045	1.397GlnPhe: 1.397 ± 0.036	3.17GlnGly: 3.17 ± 0.051	1.288GlnHis: 1.288 ± 0.031	2.14GlnIle: 2.14 ± 0.043	1.571GlnLys: 1.571 ± 0.037	4.85GlnLeu: 4.85 ± 0.075	1.214GlnMet: 1.214 ± 0.034	1.365GlnAsn: 1.365 ± 0.033	2.315GlnPro: 2.315 ± 0.048	3.205GlnGln: 3.205 ± 0.074	3.189GlnArg: 3.189 ± 0.062	2.215GlnSer: 2.215 ± 0.047	2.227GlnThr: 2.227 ± 0.048	2.965GlnVal: 2.965 ± 0.056	0.618GlnTrp: 0.618 ± 0.021	1.113GlnTyr: 1.113 ± 0.029	0.0GlnXaa: 0.0 ± 0.0
Arg	5.256ArgAla: 5.256 ± 0.074	0.621ArgCys: 0.621 ± 0.02	3.458ArgAsp: 3.458 ± 0.068	3.902ArgGlu: 3.902 ± 0.057	2.692ArgPhe: 2.692 ± 0.046	3.635ArgGly: 3.635 ± 0.059	1.684ArgHis: 1.684 ± 0.043	3.419ArgIle: 3.419 ± 0.055	2.218ArgLys: 2.218 ± 0.049	6.957ArgLeu: 6.957 ± 0.098	1.629ArgMet: 1.629 ± 0.036	2.061ArgAsn: 2.061 ± 0.048	2.46ArgPro: 2.46 ± 0.05	3.082ArgGln: 3.082 ± 0.055	3.8ArgArg: 3.8 ± 0.069	2.875ArgSer: 2.875 ± 0.057	2.788ArgThr: 2.788 ± 0.043	4.215ArgVal: 4.215 ± 0.062	1.015ArgTrp: 1.015 ± 0.03	2.27ArgTyr: 2.27 ± 0.047	0.0ArgXaa: 0.0 ± 0.0
Ser	5.854SerAla: 5.854 ± 0.077	0.539SerCys: 0.539 ± 0.026	3.204SerAsp: 3.204 ± 0.061	3.056SerGlu: 3.056 ± 0.056	2.151SerPhe: 2.151 ± 0.043	5.331SerGly: 5.331 ± 0.099	1.349SerHis: 1.349 ± 0.035	2.7SerIle: 2.7 ± 0.049	1.743SerLys: 1.743 ± 0.044	6.577SerLeu: 6.577 ± 0.093	1.428SerMet: 1.428 ± 0.034	1.714SerAsn: 1.714 ± 0.04	2.596SerPro: 2.596 ± 0.051	2.464SerGln: 2.464 ± 0.049	3.539SerArg: 3.539 ± 0.054	3.336SerSer: 3.336 ± 0.063	2.917SerThr: 2.917 ± 0.06	4.261SerVal: 4.261 ± 0.064	0.954SerTrp: 0.954 ± 0.028	1.472SerTyr: 1.472 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.375ThrAla: 5.375 ± 0.077	0.48ThrCys: 0.48 ± 0.017	2.678ThrAsp: 2.678 ± 0.047	2.413ThrGlu: 2.413 ± 0.048	2.019ThrPhe: 2.019 ± 0.044	4.78ThrGly: 4.78 ± 0.083	1.315ThrHis: 1.315 ± 0.032	2.718ThrIle: 2.718 ± 0.05	1.376ThrLys: 1.376 ± 0.036	8.042ThrLeu: 8.042 ± 0.099	1.133ThrMet: 1.133 ± 0.026	1.538ThrAsn: 1.538 ± 0.036	3.536ThrPro: 3.536 ± 0.06	2.229ThrGln: 2.229 ± 0.043	3.534ThrArg: 3.534 ± 0.055	2.808ThrSer: 2.808 ± 0.055	3.025ThrThr: 3.025 ± 0.062	4.128ThrVal: 4.128 ± 0.1	0.884ThrTrp: 0.884 ± 0.031	1.037ThrTyr: 1.037 ± 0.033	0.0ThrXaa: 0.0 ± 0.0
Val	7.541ValAla: 7.541 ± 0.093	0.74ValCys: 0.74 ± 0.023	3.899ValAsp: 3.899 ± 0.054	4.068ValGlu: 4.068 ± 0.066	2.526ValPhe: 2.526 ± 0.051	5.031ValGly: 5.031 ± 0.07	1.3ValHis: 1.3 ± 0.036	4.311ValIle: 4.311 ± 0.07	2.937ValLys: 2.937 ± 0.053	7.45ValLeu: 7.45 ± 0.088	2.251ValMet: 2.251 ± 0.041	2.83ValAsn: 2.83 ± 0.065	3.225ValPro: 3.225 ± 0.052	2.47ValGln: 2.47 ± 0.051	4.01ValArg: 4.01 ± 0.062	4.56ValSer: 4.56 ± 0.059	4.568ValThr: 4.568 ± 0.095	5.9ValVal: 5.9 ± 0.087	1.024ValTrp: 1.024 ± 0.03	1.66ValTyr: 1.66 ± 0.038	0.0ValXaa: 0.0 ± 0.0
Trp	1.051TrpAla: 1.051 ± 0.031	0.195TrpCys: 0.195 ± 0.012	0.686TrpAsp: 0.686 ± 0.023	0.617TrpGlu: 0.617 ± 0.023	0.717TrpPhe: 0.717 ± 0.024	0.926TrpGly: 0.926 ± 0.031	0.493TrpHis: 0.493 ± 0.02	0.712TrpIle: 0.712 ± 0.028	0.491TrpLys: 0.491 ± 0.023	2.346TrpLeu: 2.346 ± 0.053	0.44TrpMet: 0.44 ± 0.021	0.467TrpAsn: 0.467 ± 0.019	0.693TrpPro: 0.693 ± 0.024	1.229TrpGln: 1.229 ± 0.039	1.172TrpArg: 1.172 ± 0.035	0.798TrpSer: 0.798 ± 0.031	0.586TrpThr: 0.586 ± 0.025	0.98TrpVal: 0.98 ± 0.032	0.253TrpTrp: 0.253 ± 0.014	0.477TrpTyr: 0.477 ± 0.019	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.43TyrAla: 2.43 ± 0.049	0.336TyrCys: 0.336 ± 0.014	1.553TyrAsp: 1.553 ± 0.038	1.204TyrGlu: 1.204 ± 0.029	1.09TyrPhe: 1.09 ± 0.032	2.167TyrGly: 2.167 ± 0.044	0.665TyrHis: 0.665 ± 0.023	1.281TyrIle: 1.281 ± 0.032	0.884TyrLys: 0.884 ± 0.026	2.875TyrLeu: 2.875 ± 0.049	0.557TyrMet: 0.557 ± 0.021	0.907TyrAsn: 0.907 ± 0.027	1.304TyrPro: 1.304 ± 0.035	1.562TyrGln: 1.562 ± 0.038	1.919TyrArg: 1.919 ± 0.041	1.587TyrSer: 1.587 ± 0.04	1.462TyrThr: 1.462 ± 0.037	1.665TyrVal: 1.665 ± 0.041	0.422TyrTrp: 0.422 ± 0.02	0.839TyrTyr: 0.839 ± 0.028	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3928 proteins (1227987 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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