Amino acid dipepetide frequency for Aliidiomarina haloalkalitolerans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.28AlaAla: 11.28 ± 0.159	0.942AlaCys: 0.942 ± 0.041	5.701AlaAsp: 5.701 ± 0.094	7.671AlaGlu: 7.671 ± 0.122	3.583AlaPhe: 3.583 ± 0.063	7.389AlaGly: 7.389 ± 0.117	2.091AlaHis: 2.091 ± 0.05	5.931AlaIle: 5.931 ± 0.096	3.793AlaLys: 3.793 ± 0.085	11.119AlaLeu: 11.119 ± 0.136	2.695AlaMet: 2.695 ± 0.052	3.682AlaAsn: 3.682 ± 0.073	3.553AlaPro: 3.553 ± 0.067	4.863AlaGln: 4.863 ± 0.095	5.496AlaArg: 5.496 ± 0.099	5.301AlaSer: 5.301 ± 0.09	5.107AlaThr: 5.107 ± 0.092	7.096AlaVal: 7.096 ± 0.107	1.31AlaTrp: 1.31 ± 0.042	2.441AlaTyr: 2.441 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.768CysAla: 0.768 ± 0.03	0.105CysCys: 0.105 ± 0.011	0.495CysAsp: 0.495 ± 0.023	0.508CysGlu: 0.508 ± 0.026	0.323CysPhe: 0.323 ± 0.019	0.753CysGly: 0.753 ± 0.037	0.27CysHis: 0.27 ± 0.02	0.437CysIle: 0.437 ± 0.023	0.3CysLys: 0.3 ± 0.019	0.763CysLeu: 0.763 ± 0.029	0.18CysMet: 0.18 ± 0.014	0.271CysAsn: 0.271 ± 0.02	0.412CysPro: 0.412 ± 0.025	0.404CysGln: 0.404 ± 0.023	0.477CysArg: 0.477 ± 0.026	0.555CysSer: 0.555 ± 0.028	0.441CysThr: 0.441 ± 0.024	0.544CysVal: 0.544 ± 0.032	0.115CysTrp: 0.115 ± 0.013	0.253CysTyr: 0.253 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.982AspAla: 4.982 ± 0.074	0.466AspCys: 0.466 ± 0.024	3.215AspAsp: 3.215 ± 0.069	3.775AspGlu: 3.775 ± 0.075	2.492AspPhe: 2.492 ± 0.061	3.925AspGly: 3.925 ± 0.092	1.219AspHis: 1.219 ± 0.046	3.296AspIle: 3.296 ± 0.071	2.0AspLys: 2.0 ± 0.053	5.384AspLeu: 5.384 ± 0.087	1.419AspMet: 1.419 ± 0.046	1.853AspAsn: 1.853 ± 0.053	2.259AspPro: 2.259 ± 0.06	2.201AspGln: 2.201 ± 0.053	2.871AspArg: 2.871 ± 0.069	2.893AspSer: 2.893 ± 0.059	2.404AspThr: 2.404 ± 0.054	4.019AspVal: 4.019 ± 0.065	0.934AspTrp: 0.934 ± 0.037	2.103AspTyr: 2.103 ± 0.054	0.0AspXaa: 0.0 ± 0.0
Glu	5.723GluAla: 5.723 ± 0.104	0.409GluCys: 0.409 ± 0.023	2.587GluAsp: 2.587 ± 0.07	3.652GluGlu: 3.652 ± 0.093	2.687GluPhe: 2.687 ± 0.066	3.578GluGly: 3.578 ± 0.074	1.845GluHis: 1.845 ± 0.053	3.665GluIle: 3.665 ± 0.078	2.69GluLys: 2.69 ± 0.068	7.826GluLeu: 7.826 ± 0.107	1.476GluMet: 1.476 ± 0.044	2.31GluAsn: 2.31 ± 0.056	2.478GluPro: 2.478 ± 0.062	4.747GluGln: 4.747 ± 0.105	4.909GluArg: 4.909 ± 0.089	3.246GluSer: 3.246 ± 0.062	3.033GluThr: 3.033 ± 0.061	4.455GluVal: 4.455 ± 0.083	0.795GluTrp: 0.795 ± 0.028	1.689GluTyr: 1.689 ± 0.05	0.0GluXaa: 0.0 ± 0.0
Phe	4.555PheAla: 4.555 ± 0.084	0.395PheCys: 0.395 ± 0.022	2.452PheAsp: 2.452 ± 0.055	2.214PheGlu: 2.214 ± 0.059	1.681PhePhe: 1.681 ± 0.052	3.315PheGly: 3.315 ± 0.075	0.893PheHis: 0.893 ± 0.031	2.374PheIle: 2.374 ± 0.062	1.352PheLys: 1.352 ± 0.048	3.507PheLeu: 3.507 ± 0.077	0.991PheMet: 0.991 ± 0.037	1.756PheAsn: 1.756 ± 0.052	1.547PhePro: 1.547 ± 0.052	1.476PheGln: 1.476 ± 0.042	2.131PheArg: 2.131 ± 0.055	2.778PheSer: 2.778 ± 0.066	2.315PheThr: 2.315 ± 0.056	2.962PheVal: 2.962 ± 0.071	0.547PheTrp: 0.547 ± 0.028	1.29PheTyr: 1.29 ± 0.042	0.0PheXaa: 0.0 ± 0.0
Gly	6.054GlyAla: 6.054 ± 0.106	0.767GlyCys: 0.767 ± 0.033	3.777GlyAsp: 3.777 ± 0.071	4.471GlyGlu: 4.471 ± 0.09	3.375GlyPhe: 3.375 ± 0.067	5.2GlyGly: 5.2 ± 0.103	1.764GlyHis: 1.764 ± 0.05	4.285GlyIle: 4.285 ± 0.077	3.069GlyLys: 3.069 ± 0.075	7.219GlyLeu: 7.219 ± 0.11	2.058GlyMet: 2.058 ± 0.057	2.455GlyAsn: 2.455 ± 0.062	2.05GlyPro: 2.05 ± 0.06	3.325GlyGln: 3.325 ± 0.069	4.066GlyArg: 4.066 ± 0.08	4.093GlySer: 4.093 ± 0.086	3.536GlyThr: 3.536 ± 0.076	5.595GlyVal: 5.595 ± 0.089	0.992GlyTrp: 0.992 ± 0.037	2.51GlyTyr: 2.51 ± 0.052	0.0GlyXaa: 0.0 ± 0.0
His	2.24HisAla: 2.24 ± 0.06	0.296HisCys: 0.296 ± 0.021	1.346HisAsp: 1.346 ± 0.041	1.499HisGlu: 1.499 ± 0.047	1.084HisPhe: 1.084 ± 0.038	1.937HisGly: 1.937 ± 0.058	0.658HisHis: 0.658 ± 0.028	1.281HisIle: 1.281 ± 0.045	0.743HisLys: 0.743 ± 0.032	2.273HisLeu: 2.273 ± 0.048	0.482HisMet: 0.482 ± 0.026	0.767HisAsn: 0.767 ± 0.033	1.303HisPro: 1.303 ± 0.038	1.149HisGln: 1.149 ± 0.037	1.397HisArg: 1.397 ± 0.047	1.39HisSer: 1.39 ± 0.04	1.064HisThr: 1.064 ± 0.04	1.57HisVal: 1.57 ± 0.042	0.411HisTrp: 0.411 ± 0.019	0.873HisTyr: 0.873 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	6.402IleAla: 6.402 ± 0.102	0.498IleCys: 0.498 ± 0.024	3.625IleAsp: 3.625 ± 0.059	4.023IleGlu: 4.023 ± 0.086	1.963IlePhe: 1.963 ± 0.058	4.452IleGly: 4.452 ± 0.097	1.246IleHis: 1.246 ± 0.044	2.945IleIle: 2.945 ± 0.064	1.911IleLys: 1.911 ± 0.061	5.006IleLeu: 5.006 ± 0.091	1.184IleMet: 1.184 ± 0.042	2.107IleAsn: 2.107 ± 0.061	2.565IlePro: 2.565 ± 0.069	2.394IleGln: 2.394 ± 0.049	3.296IleArg: 3.296 ± 0.063	3.278IleSer: 3.278 ± 0.065	3.045IleThr: 3.045 ± 0.062	3.842IleVal: 3.842 ± 0.082	0.642IleTrp: 0.642 ± 0.03	1.487IleTyr: 1.487 ± 0.042	0.0IleXaa: 0.0 ± 0.0
Lys	3.822LysAla: 3.822 ± 0.085	0.204LysCys: 0.204 ± 0.015	1.829LysAsp: 1.829 ± 0.063	2.273LysGlu: 2.273 ± 0.068	1.229LysPhe: 1.229 ± 0.041	2.227LysGly: 2.227 ± 0.064	0.884LysHis: 0.884 ± 0.032	1.933LysIle: 1.933 ± 0.053	1.942LysLys: 1.942 ± 0.064	3.98LysLeu: 3.98 ± 0.078	0.884LysMet: 0.884 ± 0.035	1.246LysAsn: 1.246 ± 0.047	1.845LysPro: 1.845 ± 0.055	1.995LysGln: 1.995 ± 0.053	2.39LysArg: 2.39 ± 0.059	2.077LysSer: 2.077 ± 0.06	2.041LysThr: 2.041 ± 0.058	2.803LysVal: 2.803 ± 0.068	0.396LysTrp: 0.396 ± 0.023	0.874LysTyr: 0.874 ± 0.033	0.0LysXaa: 0.0 ± 0.0
Leu	11.949LeuAla: 11.949 ± 0.15	0.848LeuCys: 0.848 ± 0.032	5.428LeuAsp: 5.428 ± 0.103	6.306LeuGlu: 6.306 ± 0.097	4.019LeuPhe: 4.019 ± 0.084	7.044LeuGly: 7.044 ± 0.102	2.443LeuHis: 2.443 ± 0.065	5.584LeuIle: 5.584 ± 0.104	3.828LeuLys: 3.828 ± 0.077	11.099LeuLeu: 11.099 ± 0.174	2.569LeuMet: 2.569 ± 0.063	4.027LeuAsn: 4.027 ± 0.076	5.323LeuPro: 5.323 ± 0.09	5.367LeuGln: 5.367 ± 0.111	6.387LeuArg: 6.387 ± 0.093	6.548LeuSer: 6.548 ± 0.11	6.17LeuThr: 6.17 ± 0.094	7.508LeuVal: 7.508 ± 0.099	1.232LeuTrp: 1.232 ± 0.045	2.468LeuTyr: 2.468 ± 0.061	0.0LeuXaa: 0.0 ± 0.0
Met	2.711MetAla: 2.711 ± 0.057	0.15MetCys: 0.15 ± 0.014	1.049MetAsp: 1.049 ± 0.037	1.12MetGlu: 1.12 ± 0.039	0.814MetPhe: 0.814 ± 0.03	1.502MetGly: 1.502 ± 0.047	0.552MetHis: 0.552 ± 0.027	1.237MetIle: 1.237 ± 0.04	1.133MetLys: 1.133 ± 0.035	2.735MetLeu: 2.735 ± 0.068	0.601MetMet: 0.601 ± 0.027	0.981MetAsn: 0.981 ± 0.035	1.216MetPro: 1.216 ± 0.041	1.36MetGln: 1.36 ± 0.044	1.523MetArg: 1.523 ± 0.045	1.751MetSer: 1.751 ± 0.049	1.605MetThr: 1.605 ± 0.041	1.708MetVal: 1.708 ± 0.048	0.222MetTrp: 0.222 ± 0.017	0.509MetTyr: 0.509 ± 0.026	0.0MetXaa: 0.0 ± 0.0
Asn	3.314AsnAla: 3.314 ± 0.065	0.315AsnCys: 0.315 ± 0.022	2.076AsnAsp: 2.076 ± 0.06	2.286AsnGlu: 2.286 ± 0.058	1.419AsnPhe: 1.419 ± 0.047	2.716AsnGly: 2.716 ± 0.063	0.871AsnHis: 0.871 ± 0.034	1.915AsnIle: 1.915 ± 0.055	1.273AsnLys: 1.273 ± 0.039	3.641AsnLeu: 3.641 ± 0.077	0.869AsnMet: 0.869 ± 0.034	1.362AsnAsn: 1.362 ± 0.051	2.133AsnPro: 2.133 ± 0.052	1.799AsnGln: 1.799 ± 0.052	2.157AsnArg: 2.157 ± 0.052	1.937AsnSer: 1.937 ± 0.049	1.916AsnThr: 1.916 ± 0.054	2.334AsnVal: 2.334 ± 0.055	0.582AsnTrp: 0.582 ± 0.032	1.132AsnTyr: 1.132 ± 0.039	0.0AsnXaa: 0.0 ± 0.0
Pro	4.291ProAla: 4.291 ± 0.086	0.298ProCys: 0.298 ± 0.021	2.652ProAsp: 2.652 ± 0.059	3.596ProGlu: 3.596 ± 0.071	1.698ProPhe: 1.698 ± 0.044	3.017ProGly: 3.017 ± 0.066	0.923ProHis: 0.923 ± 0.034	2.254ProIle: 2.254 ± 0.053	1.562ProLys: 1.562 ± 0.048	4.473ProLeu: 4.473 ± 0.084	1.032ProMet: 1.032 ± 0.032	1.656ProAsn: 1.656 ± 0.049	1.44ProPro: 1.44 ± 0.053	2.04ProGln: 2.04 ± 0.054	1.941ProArg: 1.941 ± 0.054	2.29ProSer: 2.29 ± 0.051	2.222ProThr: 2.222 ± 0.048	3.506ProVal: 3.506 ± 0.067	0.645ProTrp: 0.645 ± 0.033	1.231ProTyr: 1.231 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	5.571GlnAla: 5.571 ± 0.124	0.317GlnCys: 0.317 ± 0.019	2.061GlnAsp: 2.061 ± 0.054	2.907GlnGlu: 2.907 ± 0.071	1.884GlnPhe: 1.884 ± 0.051	3.267GlnGly: 3.267 ± 0.067	1.456GlnHis: 1.456 ± 0.048	2.543GlnIle: 2.543 ± 0.057	1.608GlnLys: 1.608 ± 0.047	5.948GlnLeu: 5.948 ± 0.111	1.056GlnMet: 1.056 ± 0.042	1.522GlnAsn: 1.522 ± 0.049	2.406GlnPro: 2.406 ± 0.051	4.098GlnGln: 4.098 ± 0.123	3.931GlnArg: 3.931 ± 0.084	2.606GlnSer: 2.606 ± 0.052	2.368GlnThr: 2.368 ± 0.057	3.885GlnVal: 3.885 ± 0.069	0.764GlnTrp: 0.764 ± 0.033	1.221GlnTyr: 1.221 ± 0.04	0.0GlnXaa: 0.0 ± 0.0
Arg	5.174ArgAla: 5.174 ± 0.077	0.448ArgCys: 0.448 ± 0.026	3.44ArgAsp: 3.44 ± 0.072	4.212ArgGlu: 4.212 ± 0.079	2.751ArgPhe: 2.751 ± 0.062	3.817ArgGly: 3.817 ± 0.075	1.485ArgHis: 1.485 ± 0.048	3.573ArgIle: 3.573 ± 0.062	2.26ArgLys: 2.26 ± 0.058	6.644ArgLeu: 6.644 ± 0.118	1.575ArgMet: 1.575 ± 0.047	2.143ArgAsn: 2.143 ± 0.051	2.201ArgPro: 2.201 ± 0.052	3.299ArgGln: 3.299 ± 0.065	3.642ArgArg: 3.642 ± 0.083	3.253ArgSer: 3.253 ± 0.065	2.68ArgThr: 2.68 ± 0.055	4.442ArgVal: 4.442 ± 0.081	1.027ArgTrp: 1.027 ± 0.036	2.107ArgTyr: 2.107 ± 0.057	0.0ArgXaa: 0.0 ± 0.0
Ser	5.864SerAla: 5.864 ± 0.095	0.456SerCys: 0.456 ± 0.023	3.167SerAsp: 3.167 ± 0.071	3.644SerGlu: 3.644 ± 0.071	2.474SerPhe: 2.474 ± 0.058	4.746SerGly: 4.746 ± 0.081	1.31SerHis: 1.31 ± 0.042	3.084SerIle: 3.084 ± 0.08	2.081SerLys: 2.081 ± 0.054	5.832SerLeu: 5.832 ± 0.096	1.534SerMet: 1.534 ± 0.044	1.965SerAsn: 1.965 ± 0.052	2.446SerPro: 2.446 ± 0.056	2.68SerGln: 2.68 ± 0.062	3.36SerArg: 3.36 ± 0.068	3.548SerSer: 3.548 ± 0.067	2.728SerThr: 2.728 ± 0.057	4.067SerVal: 4.067 ± 0.08	0.793SerTrp: 0.793 ± 0.034	1.683SerTyr: 1.683 ± 0.055	0.0SerXaa: 0.0 ± 0.0
Thr	5.257ThrAla: 5.257 ± 0.089	0.415ThrCys: 0.415 ± 0.02	2.787ThrAsp: 2.787 ± 0.062	3.132ThrGlu: 3.132 ± 0.065	2.025ThrPhe: 2.025 ± 0.056	4.185ThrGly: 4.185 ± 0.085	1.175ThrHis: 1.175 ± 0.037	2.988ThrIle: 2.988 ± 0.064	1.625ThrLys: 1.625 ± 0.05	5.936ThrLeu: 5.936 ± 0.095	1.1ThrMet: 1.1 ± 0.039	1.751ThrAsn: 1.751 ± 0.054	2.686ThrPro: 2.686 ± 0.052	2.226ThrGln: 2.226 ± 0.055	2.798ThrArg: 2.798 ± 0.062	2.925ThrSer: 2.925 ± 0.071	2.919ThrThr: 2.919 ± 0.056	3.92ThrVal: 3.92 ± 0.074	0.675ThrTrp: 0.675 ± 0.031	1.365ThrTyr: 1.365 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	7.682ValAla: 7.682 ± 0.103	0.617ValCys: 0.617 ± 0.027	3.894ValAsp: 3.894 ± 0.077	4.419ValGlu: 4.419 ± 0.077	2.977ValPhe: 2.977 ± 0.067	4.768ValGly: 4.768 ± 0.083	1.528ValHis: 1.528 ± 0.045	4.585ValIle: 4.585 ± 0.091	2.571ValLys: 2.571 ± 0.074	7.438ValLeu: 7.438 ± 0.115	1.879ValMet: 1.879 ± 0.051	2.841ValAsn: 2.841 ± 0.066	3.035ValPro: 3.035 ± 0.073	2.966ValGln: 2.966 ± 0.059	4.323ValArg: 4.323 ± 0.073	4.496ValSer: 4.496 ± 0.083	4.399ValThr: 4.399 ± 0.082	5.76ValVal: 5.76 ± 0.102	0.846ValTrp: 0.846 ± 0.032	1.873ValTyr: 1.873 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	0.866TrpAla: 0.866 ± 0.038	0.125TrpCys: 0.125 ± 0.012	0.592TrpAsp: 0.592 ± 0.029	0.542TrpGlu: 0.542 ± 0.028	0.695TrpPhe: 0.695 ± 0.033	0.768TrpGly: 0.768 ± 0.029	0.394TrpHis: 0.394 ± 0.02	0.655TrpIle: 0.655 ± 0.026	0.307TrpLys: 0.307 ± 0.022	2.146TrpLeu: 2.146 ± 0.065	0.348TrpMet: 0.348 ± 0.019	0.41TrpAsn: 0.41 ± 0.025	0.557TrpPro: 0.557 ± 0.027	1.279TrpGln: 1.279 ± 0.043	1.011TrpArg: 1.011 ± 0.036	0.754TrpSer: 0.754 ± 0.035	0.503TrpThr: 0.503 ± 0.028	0.964TrpVal: 0.964 ± 0.037	0.246TrpTrp: 0.246 ± 0.02	0.441TrpTyr: 0.441 ± 0.024	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.54TyrAla: 2.54 ± 0.062	0.302TyrCys: 0.302 ± 0.021	1.534TyrAsp: 1.534 ± 0.044	1.552TyrGlu: 1.552 ± 0.045	1.362TyrPhe: 1.362 ± 0.046	2.055TyrGly: 2.055 ± 0.056	0.754TyrHis: 0.754 ± 0.03	1.345TyrIle: 1.345 ± 0.045	0.829TyrLys: 0.829 ± 0.035	3.179TyrLeu: 3.179 ± 0.077	0.545TyrMet: 0.545 ± 0.03	0.944TyrAsn: 0.944 ± 0.036	1.31TyrPro: 1.31 ± 0.039	1.749TyrGln: 1.749 ± 0.046	2.068TyrArg: 2.068 ± 0.057	1.744TyrSer: 1.744 ± 0.051	1.393TyrThr: 1.393 ± 0.04	1.917TyrVal: 1.917 ± 0.046	0.429TyrTrp: 0.429 ± 0.023	0.9TyrTyr: 0.9 ± 0.037	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2391 proteins (807456 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---