Amino acid dipepetide frequency for Lysobacter aestuarii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.382AlaAla: 17.382 ± 0.186	1.457AlaCys: 1.457 ± 0.04	7.759AlaAsp: 7.759 ± 0.158	7.178AlaGlu: 7.178 ± 0.104	4.331AlaPhe: 4.331 ± 0.077	11.719AlaGly: 11.719 ± 0.108	2.825AlaHis: 2.825 ± 0.052	5.511AlaIle: 5.511 ± 0.066	2.705AlaLys: 2.705 ± 0.071	15.448AlaLeu: 15.448 ± 0.158	3.575AlaMet: 3.575 ± 0.072	2.712AlaAsn: 2.712 ± 0.051	6.949AlaPro: 6.949 ± 0.099	4.303AlaGln: 4.303 ± 0.076	11.377AlaArg: 11.377 ± 0.134	7.179AlaSer: 7.179 ± 0.092	6.629AlaThr: 6.629 ± 0.103	8.713AlaVal: 8.713 ± 0.107	2.332AlaTrp: 2.332 ± 0.055	2.591AlaTyr: 2.591 ± 0.051	0.0AlaXaa: 0.0 ± 0.0
Cys	0.984CysAla: 0.984 ± 0.032	0.097CysCys: 0.097 ± 0.01	0.482CysAsp: 0.482 ± 0.022	0.463CysGlu: 0.463 ± 0.026	0.266CysPhe: 0.266 ± 0.015	0.9CysGly: 0.9 ± 0.031	0.222CysHis: 0.222 ± 0.014	0.336CysIle: 0.336 ± 0.019	0.149CysLys: 0.149 ± 0.011	0.855CysLeu: 0.855 ± 0.029	0.177CysMet: 0.177 ± 0.013	0.211CysAsn: 0.211 ± 0.016	0.461CysPro: 0.461 ± 0.024	0.247CysGln: 0.247 ± 0.016	0.635CysArg: 0.635 ± 0.024	0.487CysSer: 0.487 ± 0.024	0.462CysThr: 0.462 ± 0.026	0.663CysVal: 0.663 ± 0.026	0.114CysTrp: 0.114 ± 0.009	0.18CysTyr: 0.18 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	10.11AspAla: 10.11 ± 0.186	0.466AspCys: 0.466 ± 0.019	3.781AspAsp: 3.781 ± 0.07	3.63AspGlu: 3.63 ± 0.056	2.112AspPhe: 2.112 ± 0.048	6.37AspGly: 6.37 ± 0.091	1.211AspHis: 1.211 ± 0.036	2.486AspIle: 2.486 ± 0.05	1.376AspLys: 1.376 ± 0.047	5.571AspLeu: 5.571 ± 0.077	1.271AspMet: 1.271 ± 0.039	1.303AspAsn: 1.303 ± 0.038	3.915AspPro: 3.915 ± 0.065	1.514AspGln: 1.514 ± 0.046	4.512AspArg: 4.512 ± 0.069	2.431AspSer: 2.431 ± 0.046	3.101AspThr: 3.101 ± 0.061	4.534AspVal: 4.534 ± 0.074	1.233AspTrp: 1.233 ± 0.037	1.646AspTyr: 1.646 ± 0.045	0.0AspXaa: 0.0 ± 0.0
Glu	8.459GluAla: 8.459 ± 0.122	0.354GluCys: 0.354 ± 0.019	2.921GluAsp: 2.921 ± 0.053	2.412GluGlu: 2.412 ± 0.063	1.649GluPhe: 1.649 ± 0.045	4.797GluGly: 4.797 ± 0.077	1.427GluHis: 1.427 ± 0.042	2.395GluIle: 2.395 ± 0.048	1.436GluLys: 1.436 ± 0.049	5.748GluLeu: 5.748 ± 0.086	1.179GluMet: 1.179 ± 0.04	1.122GluAsn: 1.122 ± 0.033	2.728GluPro: 2.728 ± 0.052	2.244GluGln: 2.244 ± 0.055	5.554GluArg: 5.554 ± 0.081	2.761GluSer: 2.761 ± 0.053	2.586GluThr: 2.586 ± 0.054	4.308GluVal: 4.308 ± 0.068	0.789GluTrp: 0.789 ± 0.03	1.179GluTyr: 1.179 ± 0.038	0.0GluXaa: 0.0 ± 0.0
Phe	4.016PheAla: 4.016 ± 0.079	0.316PheCys: 0.316 ± 0.02	2.828PheAsp: 2.828 ± 0.056	2.215PheGlu: 2.215 ± 0.042	1.153PhePhe: 1.153 ± 0.037	3.363PheGly: 3.363 ± 0.074	0.749PheHis: 0.749 ± 0.028	1.211PheIle: 1.211 ± 0.032	0.795PheLys: 0.795 ± 0.034	2.86PheLeu: 2.86 ± 0.059	0.697PheMet: 0.697 ± 0.027	1.028PheAsn: 1.028 ± 0.034	1.43PhePro: 1.43 ± 0.036	0.947PheGln: 0.947 ± 0.028	2.148PheArg: 2.148 ± 0.043	1.898PheSer: 1.898 ± 0.038	1.62PheThr: 1.62 ± 0.045	2.521PheVal: 2.521 ± 0.061	0.486PheTrp: 0.486 ± 0.023	0.819PheTyr: 0.819 ± 0.029	0.0PheXaa: 0.0 ± 0.0
Gly	9.549GlyAla: 9.549 ± 0.108	0.821GlyCys: 0.821 ± 0.029	5.595GlyAsp: 5.595 ± 0.078	5.513GlyGlu: 5.513 ± 0.082	3.422GlyPhe: 3.422 ± 0.058	7.861GlyGly: 7.861 ± 0.11	2.22GlyHis: 2.22 ± 0.05	4.073GlyIle: 4.073 ± 0.06	2.736GlyLys: 2.736 ± 0.057	9.392GlyLeu: 9.392 ± 0.112	2.383GlyMet: 2.383 ± 0.046	2.369GlyAsn: 2.369 ± 0.061	3.592GlyPro: 3.592 ± 0.063	3.068GlyGln: 3.068 ± 0.055	7.042GlyArg: 7.042 ± 0.101	4.757GlySer: 4.757 ± 0.075	4.561GlyThr: 4.561 ± 0.084	6.517GlyVal: 6.517 ± 0.091	1.66GlyTrp: 1.66 ± 0.041	2.378GlyTyr: 2.378 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	3.42HisAla: 3.42 ± 0.058	0.267HisCys: 0.267 ± 0.015	1.481HisAsp: 1.481 ± 0.033	1.23HisGlu: 1.23 ± 0.035	0.872HisPhe: 0.872 ± 0.03	2.413HisGly: 2.413 ± 0.049	0.637HisHis: 0.637 ± 0.025	0.62HisIle: 0.62 ± 0.026	0.41HisLys: 0.41 ± 0.021	2.203HisLeu: 2.203 ± 0.048	0.415HisMet: 0.415 ± 0.021	0.427HisAsn: 0.427 ± 0.02	1.542HisPro: 1.542 ± 0.04	0.648HisGln: 0.648 ± 0.024	1.801HisArg: 1.801 ± 0.047	0.877HisSer: 0.877 ± 0.03	0.861HisThr: 0.861 ± 0.025	1.817HisVal: 1.817 ± 0.046	0.451HisTrp: 0.451 ± 0.02	0.616HisTyr: 0.616 ± 0.024	0.0HisXaa: 0.0 ± 0.0
Ile	5.719IleAla: 5.719 ± 0.082	0.317IleCys: 0.317 ± 0.02	3.387IleAsp: 3.387 ± 0.062	3.17IleGlu: 3.17 ± 0.06	1.007IlePhe: 1.007 ± 0.03	4.016IleGly: 4.016 ± 0.07	0.827IleHis: 0.827 ± 0.026	1.166IleIle: 1.166 ± 0.044	0.982IleLys: 0.982 ± 0.038	2.896IleLeu: 2.896 ± 0.062	0.513IleMet: 0.513 ± 0.023	1.083IleAsn: 1.083 ± 0.034	1.962IlePro: 1.962 ± 0.045	1.088IleGln: 1.088 ± 0.035	2.672IleArg: 2.672 ± 0.055	1.874IleSer: 1.874 ± 0.046	1.961IleThr: 1.961 ± 0.052	3.124IleVal: 3.124 ± 0.056	0.417IleTrp: 0.417 ± 0.023	0.723IleTyr: 0.723 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	3.195LysAla: 3.195 ± 0.078	0.126LysCys: 0.126 ± 0.012	1.305LysAsp: 1.305 ± 0.044	1.0LysGlu: 1.0 ± 0.036	0.636LysPhe: 0.636 ± 0.022	1.957LysGly: 1.957 ± 0.05	0.517LysHis: 0.517 ± 0.022	0.903LysIle: 0.903 ± 0.037	0.876LysLys: 0.876 ± 0.049	2.486LysLeu: 2.486 ± 0.054	0.524LysMet: 0.524 ± 0.022	0.51LysAsn: 0.51 ± 0.023	1.621LysPro: 1.621 ± 0.042	0.89LysGln: 0.89 ± 0.031	1.969LysArg: 1.969 ± 0.048	1.294LysSer: 1.294 ± 0.041	1.197LysThr: 1.197 ± 0.039	1.884LysVal: 1.884 ± 0.051	0.265LysTrp: 0.265 ± 0.015	0.516LysTyr: 0.516 ± 0.023	0.0LysXaa: 0.0 ± 0.0
Leu	15.623LeuAla: 15.623 ± 0.167	0.865LeuCys: 0.865 ± 0.031	7.229LeuAsp: 7.229 ± 0.093	5.86LeuGlu: 5.86 ± 0.074	3.333LeuPhe: 3.333 ± 0.064	8.968LeuGly: 8.968 ± 0.106	2.397LeuHis: 2.397 ± 0.054	3.061LeuIle: 3.061 ± 0.07	2.641LeuLys: 2.641 ± 0.052	11.208LeuLeu: 11.208 ± 0.161	2.149LeuMet: 2.149 ± 0.049	2.127LeuAsn: 2.127 ± 0.047	6.486LeuPro: 6.486 ± 0.098	3.451LeuGln: 3.451 ± 0.066	8.602LeuArg: 8.602 ± 0.111	5.745LeuSer: 5.745 ± 0.083	4.176LeuThr: 4.176 ± 0.067	8.469LeuVal: 8.469 ± 0.116	1.348LeuTrp: 1.348 ± 0.046	2.087LeuTyr: 2.087 ± 0.043	0.0LeuXaa: 0.0 ± 0.0
Met	2.939MetAla: 2.939 ± 0.057	0.15MetCys: 0.15 ± 0.013	1.181MetAsp: 1.181 ± 0.035	0.982MetGlu: 0.982 ± 0.03	0.677MetPhe: 0.677 ± 0.027	1.701MetGly: 1.701 ± 0.036	0.514MetHis: 0.514 ± 0.025	0.847MetIle: 0.847 ± 0.035	0.782MetLys: 0.782 ± 0.032	2.451MetLeu: 2.451 ± 0.056	0.435MetMet: 0.435 ± 0.021	0.644MetAsn: 0.644 ± 0.028	1.495MetPro: 1.495 ± 0.039	0.884MetGln: 0.884 ± 0.03	1.782MetArg: 1.782 ± 0.041	1.508MetSer: 1.508 ± 0.037	1.344MetThr: 1.344 ± 0.033	1.486MetVal: 1.486 ± 0.04	0.21MetTrp: 0.21 ± 0.016	0.371MetTyr: 0.371 ± 0.021	0.0MetXaa: 0.0 ± 0.0
Asn	3.17AsnAla: 3.17 ± 0.062	0.202AsnCys: 0.202 ± 0.013	1.351AsnAsp: 1.351 ± 0.038	1.103AsnGlu: 1.103 ± 0.036	0.803AsnPhe: 0.803 ± 0.03	2.182AsnGly: 2.182 ± 0.061	0.456AsnHis: 0.456 ± 0.021	0.952AsnIle: 0.952 ± 0.028	0.526AsnLys: 0.526 ± 0.025	2.285AsnLeu: 2.285 ± 0.051	0.402AsnMet: 0.402 ± 0.021	0.585AsnAsn: 0.585 ± 0.027	1.686AsnPro: 1.686 ± 0.042	0.636AsnGln: 0.636 ± 0.027	1.699AsnArg: 1.699 ± 0.037	0.975AsnSer: 0.975 ± 0.034	1.188AsnThr: 1.188 ± 0.037	1.695AsnVal: 1.695 ± 0.048	0.368AsnTrp: 0.368 ± 0.02	0.551AsnTyr: 0.551 ± 0.025	0.0AsnXaa: 0.0 ± 0.0
Pro	7.825ProAla: 7.825 ± 0.105	0.351ProCys: 0.351 ± 0.018	4.031ProAsp: 4.031 ± 0.063	3.381ProGlu: 3.381 ± 0.06	1.629ProPhe: 1.629 ± 0.045	5.815ProGly: 5.815 ± 0.082	1.099ProHis: 1.099 ± 0.034	1.807ProIle: 1.807 ± 0.041	1.051ProLys: 1.051 ± 0.034	5.415ProLeu: 5.415 ± 0.08	1.374ProMet: 1.374 ± 0.038	1.147ProAsn: 1.147 ± 0.037	3.327ProPro: 3.327 ± 0.072	1.502ProGln: 1.502 ± 0.037	4.184ProArg: 4.184 ± 0.073	2.789ProSer: 2.789 ± 0.062	2.495ProThr: 2.495 ± 0.059	4.567ProVal: 4.567 ± 0.073	0.914ProTrp: 0.914 ± 0.028	1.153ProTyr: 1.153 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.231GlnAla: 5.231 ± 0.077	0.239GlnCys: 0.239 ± 0.013	1.558GlnAsp: 1.558 ± 0.039	1.319GlnGlu: 1.319 ± 0.042	0.94GlnPhe: 0.94 ± 0.034	2.688GlnGly: 2.688 ± 0.055	0.745GlnHis: 0.745 ± 0.027	1.098GlnIle: 1.098 ± 0.035	0.756GlnLys: 0.756 ± 0.03	3.468GlnLeu: 3.468 ± 0.057	0.706GlnMet: 0.706 ± 0.027	0.571GlnAsn: 0.571 ± 0.025	1.829GlnPro: 1.829 ± 0.042	1.355GlnGln: 1.355 ± 0.041	3.046GlnArg: 3.046 ± 0.055	1.56GlnSer: 1.56 ± 0.041	1.275GlnThr: 1.275 ± 0.034	2.919GlnVal: 2.919 ± 0.051	0.567GlnTrp: 0.567 ± 0.023	0.704GlnTyr: 0.704 ± 0.026	0.0GlnXaa: 0.0 ± 0.0
Arg	9.14ArgAla: 9.14 ± 0.114	0.586ArgCys: 0.586 ± 0.028	5.075ArgAsp: 5.075 ± 0.085	5.276ArgGlu: 5.276 ± 0.081	3.165ArgPhe: 3.165 ± 0.063	5.766ArgGly: 5.766 ± 0.089	2.305ArgHis: 2.305 ± 0.049	3.981ArgIle: 3.981 ± 0.073	1.916ArgLys: 1.916 ± 0.051	9.214ArgLeu: 9.214 ± 0.128	2.058ArgMet: 2.058 ± 0.043	1.849ArgAsn: 1.849 ± 0.04	4.106ArgPro: 4.106 ± 0.071	2.952ArgGln: 2.952 ± 0.053	6.718ArgArg: 6.718 ± 0.102	3.671ArgSer: 3.671 ± 0.061	3.279ArgThr: 3.279 ± 0.055	5.881ArgVal: 5.881 ± 0.092	1.427ArgTrp: 1.427 ± 0.039	2.247ArgTyr: 2.247 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	5.93SerAla: 5.93 ± 0.092	0.394SerCys: 0.394 ± 0.018	2.814SerAsp: 2.814 ± 0.057	2.509SerGlu: 2.509 ± 0.048	1.702SerPhe: 1.702 ± 0.043	5.214SerGly: 5.214 ± 0.084	1.166SerHis: 1.166 ± 0.032	2.16SerIle: 2.16 ± 0.048	1.164SerLys: 1.164 ± 0.038	5.346SerLeu: 5.346 ± 0.078	1.171SerMet: 1.171 ± 0.034	1.331SerAsn: 1.331 ± 0.043	3.085SerPro: 3.085 ± 0.054	1.68SerGln: 1.68 ± 0.045	4.054SerArg: 4.054 ± 0.07	2.604SerSer: 2.604 ± 0.07	2.668SerThr: 2.668 ± 0.051	3.744SerVal: 3.744 ± 0.073	0.761SerTrp: 0.761 ± 0.028	1.166SerTyr: 1.166 ± 0.039	0.0SerXaa: 0.0 ± 0.0
Thr	5.709ThrAla: 5.709 ± 0.088	0.425ThrCys: 0.425 ± 0.026	2.625ThrAsp: 2.625 ± 0.052	2.069ThrGlu: 2.069 ± 0.049	1.39ThrPhe: 1.39 ± 0.039	4.729ThrGly: 4.729 ± 0.079	1.141ThrHis: 1.141 ± 0.033	1.862ThrIle: 1.862 ± 0.042	0.739ThrLys: 0.739 ± 0.03	5.854ThrLeu: 5.854 ± 0.082	0.845ThrMet: 0.845 ± 0.029	0.911ThrAsn: 0.911 ± 0.041	3.507ThrPro: 3.507 ± 0.062	1.338ThrGln: 1.338 ± 0.039	3.795ThrArg: 3.795 ± 0.054	2.252ThrSer: 2.252 ± 0.056	2.427ThrThr: 2.427 ± 0.069	3.988ThrVal: 3.988 ± 0.065	0.663ThrTrp: 0.663 ± 0.027	1.13ThrTyr: 1.13 ± 0.044	0.0ThrXaa: 0.0 ± 0.0
Val	10.141ValAla: 10.141 ± 0.116	0.645ValCys: 0.645 ± 0.025	5.054ValAsp: 5.054 ± 0.077	4.951ValGlu: 4.951 ± 0.076	2.609ValPhe: 2.609 ± 0.061	5.992ValGly: 5.992 ± 0.085	1.712ValHis: 1.712 ± 0.043	3.036ValIle: 3.036 ± 0.061	1.753ValLys: 1.753 ± 0.043	8.42ValLeu: 8.42 ± 0.11	1.623ValMet: 1.623 ± 0.046	1.814ValAsn: 1.814 ± 0.045	4.164ValPro: 4.164 ± 0.069	2.325ValGln: 2.325 ± 0.049	5.388ValArg: 5.388 ± 0.091	3.969ValSer: 3.969 ± 0.067	3.595ValThr: 3.595 ± 0.089	6.463ValVal: 6.463 ± 0.095	0.814ValTrp: 0.814 ± 0.029	1.481ValTyr: 1.481 ± 0.04	0.0ValXaa: 0.0 ± 0.0
Trp	1.417TrpAla: 1.417 ± 0.04	0.13TrpCys: 0.13 ± 0.01	0.708TrpAsp: 0.708 ± 0.027	0.604TrpGlu: 0.604 ± 0.028	0.578TrpPhe: 0.578 ± 0.024	0.998TrpGly: 0.998 ± 0.035	0.382TrpHis: 0.382 ± 0.018	0.683TrpIle: 0.683 ± 0.028	0.406TrpLys: 0.406 ± 0.019	2.246TrpLeu: 2.246 ± 0.058	0.455TrpMet: 0.455 ± 0.024	0.459TrpAsn: 0.459 ± 0.023	0.843TrpPro: 0.843 ± 0.03	0.722TrpGln: 0.722 ± 0.027	1.521TrpArg: 1.521 ± 0.045	0.874TrpSer: 0.874 ± 0.031	0.82TrpThr: 0.82 ± 0.031	1.007TrpVal: 1.007 ± 0.034	0.336TrpTrp: 0.336 ± 0.021	0.357TrpTyr: 0.357 ± 0.016	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.716TyrAla: 2.716 ± 0.052	0.185TyrCys: 0.185 ± 0.014	1.41TyrAsp: 1.41 ± 0.041	1.184TyrGlu: 1.184 ± 0.035	0.828TyrPhe: 0.828 ± 0.028	2.061TyrGly: 2.061 ± 0.051	0.454TyrHis: 0.454 ± 0.021	0.717TyrIle: 0.717 ± 0.026	0.469TyrLys: 0.469 ± 0.022	2.46TyrLeu: 2.46 ± 0.044	0.431TyrMet: 0.431 ± 0.021	0.61TyrAsn: 0.61 ± 0.028	1.13TyrPro: 1.13 ± 0.034	0.778TyrGln: 0.778 ± 0.026	2.111TyrArg: 2.111 ± 0.048	1.162TyrSer: 1.162 ± 0.037	1.154TyrThr: 1.154 ± 0.038	1.647TyrVal: 1.647 ± 0.044	0.389TyrTrp: 0.389 ± 0.021	0.606TyrTyr: 0.606 ± 0.025	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 3124 proteins (1031292 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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