Amino acid dipepetide frequency for Sphingomonas parva

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
22.617AlaAla: 22.617 ± 0.235
1.124AlaCys: 1.124 ± 0.031
7.396AlaAsp: 7.396 ± 0.069
8.875AlaGlu: 8.875 ± 0.115
4.485AlaPhe: 4.485 ± 0.061
12.661AlaGly: 12.661 ± 0.146
2.165AlaHis: 2.165 ± 0.048
6.312AlaIle: 6.312 ± 0.074
3.247AlaLys: 3.247 ± 0.057
14.762AlaLeu: 14.762 ± 0.15
3.362AlaMet: 3.362 ± 0.05
2.856AlaAsn: 2.856 ± 0.061
7.181AlaPro: 7.181 ± 0.096
4.103AlaGln: 4.103 ± 0.072
11.212AlaArg: 11.212 ± 0.136
6.955AlaSer: 6.955 ± 0.075
6.282AlaThr: 6.282 ± 0.078
8.849AlaVal: 8.849 ± 0.097
1.802AlaTrp: 1.802 ± 0.042
2.479AlaTyr: 2.479 ± 0.047
0.0AlaXaa: 0.0 ± 0.0
Cys
1.006CysAla: 1.006 ± 0.033
0.115CysCys: 0.115 ± 0.01
0.454CysAsp: 0.454 ± 0.02
0.388CysGlu: 0.388 ± 0.017
0.272CysPhe: 0.272 ± 0.015
0.869CysGly: 0.869 ± 0.031
0.187CysHis: 0.187 ± 0.012
0.319CysIle: 0.319 ± 0.017
0.118CysLys: 0.118 ± 0.009
0.7CysLeu: 0.7 ± 0.025
0.125CysMet: 0.125 ± 0.009
0.16CysAsn: 0.16 ± 0.012
0.436CysPro: 0.436 ± 0.02
0.162CysGln: 0.162 ± 0.011
0.658CysArg: 0.658 ± 0.026
0.452CysSer: 0.452 ± 0.02
0.419CysThr: 0.419 ± 0.019
0.489CysVal: 0.489 ± 0.022
0.104CysTrp: 0.104 ± 0.009
0.147CysTyr: 0.147 ± 0.011
0.0CysXaa: 0.0 ± 0.0
Asp
7.626AspAla: 7.626 ± 0.089
0.432AspCys: 0.432 ± 0.019
3.221AspAsp: 3.221 ± 0.076
3.578AspGlu: 3.578 ± 0.059
2.115AspPhe: 2.115 ± 0.043
5.742AspGly: 5.742 ± 0.112
1.154AspHis: 1.154 ± 0.031
2.441AspIle: 2.441 ± 0.048
1.207AspLys: 1.207 ± 0.029
5.798AspLeu: 5.798 ± 0.06
1.093AspMet: 1.093 ± 0.03
1.149AspAsn: 1.149 ± 0.043
3.965AspPro: 3.965 ± 0.061
1.675AspGln: 1.675 ± 0.036
5.066AspArg: 5.066 ± 0.072
2.256AspSer: 2.256 ± 0.043
2.391AspThr: 2.391 ± 0.07
4.236AspVal: 4.236 ± 0.076
1.022AspTrp: 1.022 ± 0.034
1.567AspTyr: 1.567 ± 0.035
0.0AspXaa: 0.0 ± 0.0
Glu
8.921GluAla: 8.921 ± 0.098
0.32GluCys: 0.32 ± 0.015
2.956GluAsp: 2.956 ± 0.055
3.6GluGlu: 3.6 ± 0.074
1.536GluPhe: 1.536 ± 0.036
4.931GluGly: 4.931 ± 0.068
1.137GluHis: 1.137 ± 0.032
3.219GluIle: 3.219 ± 0.053
1.644GluLys: 1.644 ± 0.039
5.247GluLeu: 5.247 ± 0.064
1.382GluMet: 1.382 ± 0.036
1.29GluAsn: 1.29 ± 0.033
2.729GluPro: 2.729 ± 0.053
2.186GluGln: 2.186 ± 0.043
5.737GluArg: 5.737 ± 0.089
2.552GluSer: 2.552 ± 0.044
3.464GluThr: 3.464 ± 0.058
3.752GluVal: 3.752 ± 0.057
0.758GluTrp: 0.758 ± 0.025
0.834GluTyr: 0.834 ± 0.03
0.0GluXaa: 0.0 ± 0.0
Phe
4.748PheAla: 4.748 ± 0.064
0.297PheCys: 0.297 ± 0.016
2.569PheAsp: 2.569 ± 0.048
2.132PheGlu: 2.132 ± 0.041
1.22PhePhe: 1.22 ± 0.035
3.591PheGly: 3.591 ± 0.059
0.719PheHis: 0.719 ± 0.021
1.236PheIle: 1.236 ± 0.032
0.69PheLys: 0.69 ± 0.023
3.22PheLeu: 3.22 ± 0.057
0.586PheMet: 0.586 ± 0.023
0.973PheAsn: 0.973 ± 0.036
1.442PhePro: 1.442 ± 0.035
0.867PheGln: 0.867 ± 0.027
2.439PheArg: 2.439 ± 0.042
1.975PheSer: 1.975 ± 0.04
1.881PheThr: 1.881 ± 0.039
2.793PheVal: 2.793 ± 0.05
0.512PheTrp: 0.512 ± 0.024
0.887PheTyr: 0.887 ± 0.026
0.0PheXaa: 0.0 ± 0.0
Gly
11.113GlyAla: 11.113 ± 0.134
0.848GlyCys: 0.848 ± 0.028
5.16GlyAsp: 5.16 ± 0.104
5.437GlyGlu: 5.437 ± 0.072
3.572GlyPhe: 3.572 ± 0.056
9.283GlyGly: 9.283 ± 0.174
1.828GlyHis: 1.828 ± 0.039
4.135GlyIle: 4.135 ± 0.054
2.653GlyLys: 2.653 ± 0.05
8.924GlyLeu: 8.924 ± 0.095
2.025GlyMet: 2.025 ± 0.039
2.413GlyAsn: 2.413 ± 0.085
3.904GlyPro: 3.904 ± 0.053
2.746GlyGln: 2.746 ± 0.051
7.843GlyArg: 7.843 ± 0.098
5.075GlySer: 5.075 ± 0.091
5.157GlyThr: 5.157 ± 0.138
6.221GlyVal: 6.221 ± 0.079
1.696GlyTrp: 1.696 ± 0.04
2.165GlyTyr: 2.165 ± 0.041
0.0GlyXaa: 0.0 ± 0.0
His
2.246HisAla: 2.246 ± 0.047
0.189HisCys: 0.189 ± 0.013
1.115HisAsp: 1.115 ± 0.03
1.016HisGlu: 1.016 ± 0.032
0.769HisPhe: 0.769 ± 0.025
1.888HisGly: 1.888 ± 0.04
0.544HisHis: 0.544 ± 0.023
0.73HisIle: 0.73 ± 0.022
0.369HisLys: 0.369 ± 0.019
1.922HisLeu: 1.922 ± 0.041
0.39HisMet: 0.39 ± 0.016
0.401HisAsn: 0.401 ± 0.018
1.237HisPro: 1.237 ± 0.032
0.568HisGln: 0.568 ± 0.021
1.567HisArg: 1.567 ± 0.035
0.884HisSer: 0.884 ± 0.024
0.536HisThr: 0.536 ± 0.021
1.424HisVal: 1.424 ± 0.034
0.319HisTrp: 0.319 ± 0.015
0.528HisTyr: 0.528 ± 0.019
0.0HisXaa: 0.0 ± 0.0
Ile
7.178IleAla: 7.178 ± 0.074
0.364IleCys: 0.364 ± 0.015
3.572IleAsp: 3.572 ± 0.057
3.595IleGlu: 3.595 ± 0.056
1.374IlePhe: 1.374 ± 0.033
4.851IleGly: 4.851 ± 0.057
0.784IleHis: 0.784 ± 0.019
1.572IleIle: 1.572 ± 0.042
0.86IleLys: 0.86 ± 0.024
3.891IleLeu: 3.891 ± 0.057
0.675IleMet: 0.675 ± 0.022
1.097IleAsn: 1.097 ± 0.034
2.05IlePro: 2.05 ± 0.043
1.07IleGln: 1.07 ± 0.031
3.26IleArg: 3.26 ± 0.056
2.355IleSer: 2.355 ± 0.041
2.174IleThr: 2.174 ± 0.048
4.373IleVal: 4.373 ± 0.06
0.546IleTrp: 0.546 ± 0.021
0.871IleTyr: 0.871 ± 0.025
0.0IleXaa: 0.0 ± 0.0
Lys
3.473LysAla: 3.473 ± 0.059
0.129LysCys: 0.129 ± 0.01
1.281LysAsp: 1.281 ± 0.037
1.153LysGlu: 1.153 ± 0.033
0.586LysPhe: 0.586 ± 0.024
2.122LysGly: 2.122 ± 0.042
0.409LysHis: 0.409 ± 0.017
1.15LysIle: 1.15 ± 0.031
0.855LysLys: 0.855 ± 0.033
2.534LysLeu: 2.534 ± 0.054
0.598LysMet: 0.598 ± 0.023
0.562LysAsn: 0.562 ± 0.02
1.586LysPro: 1.586 ± 0.038
0.758LysGln: 0.758 ± 0.028
1.956LysArg: 1.956 ± 0.044
1.284LysSer: 1.284 ± 0.031
1.409LysThr: 1.409 ± 0.034
1.876LysVal: 1.876 ± 0.04
0.314LysTrp: 0.314 ± 0.015
0.451LysTyr: 0.451 ± 0.022
0.0LysXaa: 0.0 ± 0.0
Leu
15.236LeuAla: 15.236 ± 0.147
0.744LeuCys: 0.744 ± 0.024
6.041LeuAsp: 6.041 ± 0.072
5.315LeuGlu: 5.315 ± 0.074
3.633LeuPhe: 3.633 ± 0.06
8.764LeuGly: 8.764 ± 0.1
1.785LeuHis: 1.785 ± 0.038
4.643LeuIle: 4.643 ± 0.071
2.727LeuLys: 2.727 ± 0.045
10.478LeuLeu: 10.478 ± 0.148
1.828LeuMet: 1.828 ± 0.039
2.271LeuAsn: 2.271 ± 0.045
5.739LeuPro: 5.739 ± 0.076
2.649LeuGln: 2.649 ± 0.048
7.644LeuArg: 7.644 ± 0.093
5.988LeuSer: 5.988 ± 0.074
5.183LeuThr: 5.183 ± 0.074
7.543LeuVal: 7.543 ± 0.096
1.304LeuTrp: 1.304 ± 0.035
1.937LeuTyr: 1.937 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
2.866MetAla: 2.866 ± 0.045
0.114MetCys: 0.114 ± 0.01
0.934MetAsp: 0.934 ± 0.029
0.919MetGlu: 0.919 ± 0.028
0.613MetPhe: 0.613 ± 0.021
1.514MetGly: 1.514 ± 0.03
0.346MetHis: 0.346 ± 0.016
1.17MetIle: 1.17 ± 0.027
0.748MetLys: 0.748 ± 0.027
2.287MetLeu: 2.287 ± 0.047
0.519MetMet: 0.519 ± 0.021
0.603MetAsn: 0.603 ± 0.022
1.318MetPro: 1.318 ± 0.032
0.593MetGln: 0.593 ± 0.023
1.815MetArg: 1.815 ± 0.032
1.234MetSer: 1.234 ± 0.032
1.357MetThr: 1.357 ± 0.03
1.365MetVal: 1.365 ± 0.032
0.22MetTrp: 0.22 ± 0.013
0.249MetTyr: 0.249 ± 0.017
0.0MetXaa: 0.0 ± 0.0
Asn
2.968AsnAla: 2.968 ± 0.056
0.23AsnCys: 0.23 ± 0.017
1.47AsnAsp: 1.47 ± 0.068
1.113AsnGlu: 1.113 ± 0.032
0.857AsnPhe: 0.857 ± 0.028
2.419AsnGly: 2.419 ± 0.075
0.416AsnHis: 0.416 ± 0.017
1.1AsnIle: 1.1 ± 0.035
0.489AsnLys: 0.489 ± 0.02
2.401AsnLeu: 2.401 ± 0.047
0.45AsnMet: 0.45 ± 0.017
0.647AsnAsn: 0.647 ± 0.028
1.614AsnPro: 1.614 ± 0.04
0.703AsnGln: 0.703 ± 0.026
1.842AsnArg: 1.842 ± 0.037
1.204AsnSer: 1.204 ± 0.043
1.017AsnThr: 1.017 ± 0.037
1.845AsnVal: 1.845 ± 0.046
0.34AsnTrp: 0.34 ± 0.018
0.595AsnTyr: 0.595 ± 0.025
0.0AsnXaa: 0.0 ± 0.0
Pro
7.919ProAla: 7.919 ± 0.11
0.381ProCys: 0.381 ± 0.018
3.641ProAsp: 3.641 ± 0.059
3.791ProGlu: 3.791 ± 0.066
1.916ProPhe: 1.916 ± 0.039
5.158ProGly: 5.158 ± 0.07
1.013ProHis: 1.013 ± 0.031
2.341ProIle: 2.341 ± 0.047
1.344ProLys: 1.344 ± 0.032
5.145ProLeu: 5.145 ± 0.075
0.997ProMet: 0.997 ± 0.028
1.316ProAsn: 1.316 ± 0.031
3.322ProPro: 3.322 ± 0.082
1.648ProGln: 1.648 ± 0.039
3.581ProArg: 3.581 ± 0.053
2.876ProSer: 2.876 ± 0.047
2.463ProThr: 2.463 ± 0.047
4.085ProVal: 4.085 ± 0.058
0.746ProTrp: 0.746 ± 0.025
1.064ProTyr: 1.064 ± 0.033
0.0ProXaa: 0.0 ± 0.0
Gln
4.148GlnAla: 4.148 ± 0.06
0.163GlnCys: 0.163 ± 0.011
1.336GlnAsp: 1.336 ± 0.035
1.329GlnGlu: 1.329 ± 0.035
0.961GlnPhe: 0.961 ± 0.024
2.463GlnGly: 2.463 ± 0.047
0.557GlnHis: 0.557 ± 0.024
1.544GlnIle: 1.544 ± 0.03
0.743GlnLys: 0.743 ± 0.026
3.054GlnLeu: 3.054 ± 0.056
0.686GlnMet: 0.686 ± 0.024
0.724GlnAsn: 0.724 ± 0.024
1.852GlnPro: 1.852 ± 0.04
1.13GlnGln: 1.13 ± 0.039
2.506GlnArg: 2.506 ± 0.047
1.578GlnSer: 1.578 ± 0.034
1.431GlnThr: 1.431 ± 0.037
2.187GlnVal: 2.187 ± 0.045
0.383GlnTrp: 0.383 ± 0.018
0.505GlnTyr: 0.505 ± 0.021
0.0GlnXaa: 0.0 ± 0.0
Arg
9.848ArgAla: 9.848 ± 0.109
0.58ArgCys: 0.58 ± 0.024
4.533ArgAsp: 4.533 ± 0.073
4.538ArgGlu: 4.538 ± 0.082
3.343ArgPhe: 3.343 ± 0.063
5.923ArgGly: 5.923 ± 0.069
1.718ArgHis: 1.718 ± 0.039
4.469ArgIle: 4.469 ± 0.064
2.048ArgLys: 2.048 ± 0.048
9.467ArgLeu: 9.467 ± 0.104
2.025ArgMet: 2.025 ± 0.038
1.932ArgAsn: 1.932 ± 0.041
4.496ArgPro: 4.496 ± 0.088
2.505ArgGln: 2.505 ± 0.049
7.589ArgArg: 7.589 ± 0.115
4.319ArgSer: 4.319 ± 0.062
3.869ArgThr: 3.869 ± 0.053
5.182ArgVal: 5.182 ± 0.066
1.304ArgTrp: 1.304 ± 0.036
1.931ArgTyr: 1.931 ± 0.041
0.0ArgXaa: 0.0 ± 0.0
Ser
6.79SerAla: 6.79 ± 0.075
0.39SerCys: 0.39 ± 0.017
3.049SerAsp: 3.049 ± 0.053
2.802SerGlu: 2.802 ± 0.048
2.144SerPhe: 2.144 ± 0.04
5.858SerGly: 5.858 ± 0.106
0.946SerHis: 0.946 ± 0.027
2.476SerIle: 2.476 ± 0.048
1.154SerLys: 1.154 ± 0.033
5.375SerLeu: 5.375 ± 0.072
0.978SerMet: 0.978 ± 0.025
1.301SerAsn: 1.301 ± 0.031
2.941SerPro: 2.941 ± 0.056
1.376SerGln: 1.376 ± 0.036
3.932SerArg: 3.932 ± 0.057
2.826SerSer: 2.826 ± 0.069
2.542SerThr: 2.542 ± 0.058
3.715SerVal: 3.715 ± 0.057
0.843SerTrp: 0.843 ± 0.029
1.294SerTyr: 1.294 ± 0.032
0.0SerXaa: 0.0 ± 0.0
Thr
6.309ThrAla: 6.309 ± 0.087
0.367ThrCys: 0.367 ± 0.018
2.527ThrAsp: 2.527 ± 0.05
2.285ThrGlu: 2.285 ± 0.046
1.838ThrPhe: 1.838 ± 0.042
5.437ThrGly: 5.437 ± 0.098
0.807ThrHis: 0.807 ± 0.026
2.958ThrIle: 2.958 ± 0.062
1.069ThrLys: 1.069 ± 0.031
5.749ThrLeu: 5.749 ± 0.088
1.033ThrMet: 1.033 ± 0.031
1.214ThrAsn: 1.214 ± 0.04
3.255ThrPro: 3.255 ± 0.054
1.225ThrGln: 1.225 ± 0.029
3.467ThrArg: 3.467 ± 0.053
2.655ThrSer: 2.655 ± 0.066
2.478ThrThr: 2.478 ± 0.071
3.879ThrVal: 3.879 ± 0.072
0.629ThrTrp: 0.629 ± 0.021
1.058ThrTyr: 1.058 ± 0.034
0.0ThrXaa: 0.0 ± 0.0
Val
9.899ValAla: 9.899 ± 0.103
0.507ValCys: 0.507 ± 0.019
4.373ValAsp: 4.373 ± 0.061
4.579ValGlu: 4.579 ± 0.062
2.218ValPhe: 2.218 ± 0.039
5.633ValGly: 5.633 ± 0.069
1.354ValHis: 1.354 ± 0.034
3.313ValIle: 3.313 ± 0.062
1.702ValLys: 1.702 ± 0.043
6.646ValLeu: 6.646 ± 0.086
1.362ValMet: 1.362 ± 0.033
1.818ValAsn: 1.818 ± 0.052
3.994ValPro: 3.994 ± 0.064
2.035ValGln: 2.035 ± 0.045
5.895ValArg: 5.895 ± 0.072
4.146ValSer: 4.146 ± 0.07
4.416ValThr: 4.416 ± 0.069
5.202ValVal: 5.202 ± 0.071
0.859ValTrp: 0.859 ± 0.025
1.457ValTyr: 1.457 ± 0.034
0.0ValXaa: 0.0 ± 0.0
Trp
1.395TrpAla: 1.395 ± 0.033
0.115TrpCys: 0.115 ± 0.011
0.695TrpAsp: 0.695 ± 0.025
0.623TrpGlu: 0.623 ± 0.021
0.521TrpPhe: 0.521 ± 0.022
1.017TrpGly: 1.017 ± 0.034
0.316TrpHis: 0.316 ± 0.016
0.686TrpIle: 0.686 ± 0.024
0.369TrpLys: 0.369 ± 0.022
1.764TrpLeu: 1.764 ± 0.042
0.331TrpMet: 0.331 ± 0.015
0.459TrpAsn: 0.459 ± 0.018
0.724TrpPro: 0.724 ± 0.023
0.592TrpGln: 0.592 ± 0.022
1.513TrpArg: 1.513 ± 0.035
0.907TrpSer: 0.907 ± 0.026
0.864TrpThr: 0.864 ± 0.027
0.826TrpVal: 0.826 ± 0.028
0.275TrpTrp: 0.275 ± 0.015
0.32TrpTyr: 0.32 ± 0.014
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.421TyrAla: 2.421 ± 0.047
0.168TyrCys: 0.168 ± 0.011
1.413TyrAsp: 1.413 ± 0.037
1.128TyrGlu: 1.128 ± 0.029
0.806TyrPhe: 0.806 ± 0.027
2.072TyrGly: 2.072 ± 0.044
0.455TyrHis: 0.455 ± 0.018
0.699TyrIle: 0.699 ± 0.027
0.449TyrLys: 0.449 ± 0.02
2.085TyrLeu: 2.085 ± 0.037
0.338TyrMet: 0.338 ± 0.014
0.533TyrAsn: 0.533 ± 0.024
0.962TyrPro: 0.962 ± 0.032
0.689TyrGln: 0.689 ± 0.024
2.1TyrArg: 2.1 ± 0.041
1.21TyrSer: 1.21 ± 0.034
0.909TyrThr: 0.909 ± 0.024
1.566TyrVal: 1.566 ± 0.038
0.336TyrTrp: 0.336 ± 0.019
0.521TyrTyr: 0.521 ± 0.019
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4021 proteins (1299525 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski