Amino acid dipepetide frequency for Rhodopirellula pilleata

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
10.518AlaAla: 10.518 ± 0.097
1.081AlaCys: 1.081 ± 0.026
6.299AlaAsp: 6.299 ± 0.056
6.019AlaGlu: 6.019 ± 0.073
3.286AlaPhe: 3.286 ± 0.041
7.725AlaGly: 7.725 ± 0.092
1.442AlaHis: 1.442 ± 0.029
6.166AlaIle: 6.166 ± 0.058
3.711AlaLys: 3.711 ± 0.065
7.224AlaLeu: 7.224 ± 0.07
2.795AlaMet: 2.795 ± 0.048
3.295AlaAsn: 3.295 ± 0.054
3.638AlaPro: 3.638 ± 0.052
2.952AlaGln: 2.952 ± 0.037
5.107AlaArg: 5.107 ± 0.063
6.913AlaSer: 6.913 ± 0.059
6.165AlaThr: 6.165 ± 0.066
6.579AlaVal: 6.579 ± 0.066
1.32AlaTrp: 1.32 ± 0.028
1.989AlaTyr: 1.989 ± 0.034
0.0AlaXaa: 0.0 ± 0.0
Cys
0.624CysAla: 0.624 ± 0.017
0.219CysCys: 0.219 ± 0.016
0.733CysAsp: 0.733 ± 0.018
0.685CysGlu: 0.685 ± 0.022
0.432CysPhe: 0.432 ± 0.014
1.015CysGly: 1.015 ± 0.036
0.44CysHis: 0.44 ± 0.021
0.43CysIle: 0.43 ± 0.014
0.25CysLys: 0.25 ± 0.011
1.104CysLeu: 1.104 ± 0.025
0.188CysMet: 0.188 ± 0.009
0.278CysAsn: 0.278 ± 0.011
0.54CysPro: 0.54 ± 0.018
0.453CysGln: 0.453 ± 0.015
0.819CysArg: 0.819 ± 0.022
0.647CysSer: 0.647 ± 0.022
0.456CysThr: 0.456 ± 0.015
0.829CysVal: 0.829 ± 0.021
0.158CysTrp: 0.158 ± 0.009
0.28CysTyr: 0.28 ± 0.01
0.0CysXaa: 0.0 ± 0.0
Asp
6.675AspAla: 6.675 ± 0.068
0.588AspCys: 0.588 ± 0.017
4.626AspAsp: 4.626 ± 0.058
4.622AspGlu: 4.622 ± 0.046
2.454AspPhe: 2.454 ± 0.039
5.762AspGly: 5.762 ± 0.119
1.581AspHis: 1.581 ± 0.029
2.542AspIle: 2.542 ± 0.045
1.537AspLys: 1.537 ± 0.031
6.09AspLeu: 6.09 ± 0.067
0.995AspMet: 0.995 ± 0.023
1.82AspAsn: 1.82 ± 0.046
3.921AspPro: 3.921 ± 0.045
3.05AspGln: 3.05 ± 0.041
4.87AspArg: 4.87 ± 0.057
4.214AspSer: 4.214 ± 0.074
2.886AspThr: 2.886 ± 0.069
4.604AspVal: 4.604 ± 0.062
1.166AspTrp: 1.166 ± 0.022
1.575AspTyr: 1.575 ± 0.025
0.0AspXaa: 0.0 ± 0.0
Glu
5.425GluAla: 5.425 ± 0.071
0.484GluCys: 0.484 ± 0.019
2.848GluAsp: 2.848 ± 0.04
2.896GluGlu: 2.896 ± 0.051
2.224GluPhe: 2.224 ± 0.033
3.489GluGly: 3.489 ± 0.046
1.37GluHis: 1.37 ± 0.031
3.616GluIle: 3.616 ± 0.039
2.267GluLys: 2.267 ± 0.046
6.621GluLeu: 6.621 ± 0.069
1.565GluMet: 1.565 ± 0.031
2.136GluAsn: 2.136 ± 0.029
2.955GluPro: 2.955 ± 0.038
2.824GluGln: 2.824 ± 0.046
3.867GluArg: 3.867 ± 0.061
4.764GluSer: 4.764 ± 0.051
3.973GluThr: 3.973 ± 0.051
4.095GluVal: 4.095 ± 0.046
0.595GluTrp: 0.595 ± 0.017
1.229GluTyr: 1.229 ± 0.025
0.0GluXaa: 0.0 ± 0.0
Phe
3.891PheAla: 3.891 ± 0.051
0.444PheCys: 0.444 ± 0.014
3.056PheAsp: 3.056 ± 0.046
2.403PheGlu: 2.403 ± 0.031
1.422PhePhe: 1.422 ± 0.032
3.342PheGly: 3.342 ± 0.048
0.765PheHis: 0.765 ± 0.02
1.513PheIle: 1.513 ± 0.027
0.891PheLys: 0.891 ± 0.023
3.21PheLeu: 3.21 ± 0.045
0.649PheMet: 0.649 ± 0.017
1.316PheAsn: 1.316 ± 0.037
1.588PhePro: 1.588 ± 0.026
1.375PheGln: 1.375 ± 0.025
2.313PheArg: 2.313 ± 0.034
2.354PheSer: 2.354 ± 0.034
2.093PheThr: 2.093 ± 0.046
2.887PheVal: 2.887 ± 0.041
0.537PheTrp: 0.537 ± 0.015
0.871PheTyr: 0.871 ± 0.021
0.0PheXaa: 0.0 ± 0.0
Gly
5.351GlyAla: 5.351 ± 0.089
0.988GlyCys: 0.988 ± 0.031
5.207GlyAsp: 5.207 ± 0.097
4.61GlyGlu: 4.61 ± 0.047
3.112GlyPhe: 3.112 ± 0.042
7.103GlyGly: 7.103 ± 0.15
1.664GlyHis: 1.664 ± 0.033
4.045GlyIle: 4.045 ± 0.043
3.281GlyLys: 3.281 ± 0.045
6.976GlyLeu: 6.976 ± 0.063
1.861GlyMet: 1.861 ± 0.033
3.043GlyAsn: 3.043 ± 0.082
3.108GlyPro: 3.108 ± 0.043
3.117GlyGln: 3.117 ± 0.045
5.085GlyArg: 5.085 ± 0.056
5.404GlySer: 5.404 ± 0.101
4.829GlyThr: 4.829 ± 0.125
5.509GlyVal: 5.509 ± 0.062
1.304GlyTrp: 1.304 ± 0.029
2.083GlyTyr: 2.083 ± 0.034
0.0GlyXaa: 0.0 ± 0.0
His
1.999HisAla: 1.999 ± 0.035
0.352HisCys: 0.352 ± 0.013
1.447HisAsp: 1.447 ± 0.028
1.268HisGlu: 1.268 ± 0.024
0.94HisPhe: 0.94 ± 0.022
1.762HisGly: 1.762 ± 0.03
0.724HisHis: 0.724 ± 0.018
0.77HisIle: 0.77 ± 0.018
0.44HisLys: 0.44 ± 0.014
2.105HisLeu: 2.105 ± 0.033
0.313HisMet: 0.313 ± 0.013
0.61HisAsn: 0.61 ± 0.017
1.404HisPro: 1.404 ± 0.031
0.987HisGln: 0.987 ± 0.022
1.762HisArg: 1.762 ± 0.034
1.358HisSer: 1.358 ± 0.029
0.935HisThr: 0.935 ± 0.021
1.564HisVal: 1.564 ± 0.027
0.443HisTrp: 0.443 ± 0.015
0.617HisTyr: 0.617 ± 0.016
0.0HisXaa: 0.0 ± 0.0
Ile
6.516IleAla: 6.516 ± 0.056
0.549IleCys: 0.549 ± 0.018
4.738IleAsp: 4.738 ± 0.067
4.275IleGlu: 4.275 ± 0.047
1.401IlePhe: 1.401 ± 0.027
4.685IleGly: 4.685 ± 0.05
1.171IleHis: 1.171 ± 0.02
1.984IleIle: 1.984 ± 0.029
1.408IleLys: 1.408 ± 0.026
3.984IleLeu: 3.984 ± 0.045
0.727IleMet: 0.727 ± 0.02
1.855IleAsn: 1.855 ± 0.046
2.54IlePro: 2.54 ± 0.03
1.938IleGln: 1.938 ± 0.028
3.695IleArg: 3.695 ± 0.043
3.267IleSer: 3.267 ± 0.043
3.003IleThr: 3.003 ± 0.072
4.154IleVal: 4.154 ± 0.045
0.585IleTrp: 0.585 ± 0.015
1.107IleTyr: 1.107 ± 0.021
0.0IleXaa: 0.0 ± 0.0
Lys
2.802LysAla: 2.802 ± 0.047
0.271LysCys: 0.271 ± 0.011
1.573LysAsp: 1.573 ± 0.026
1.666LysGlu: 1.666 ± 0.034
1.134LysPhe: 1.134 ± 0.02
1.758LysGly: 1.758 ± 0.031
0.754LysHis: 0.754 ± 0.019
1.781LysIle: 1.781 ± 0.035
1.432LysLys: 1.432 ± 0.039
3.372LysLeu: 3.372 ± 0.051
0.851LysMet: 0.851 ± 0.021
1.107LysAsn: 1.107 ± 0.025
2.147LysPro: 2.147 ± 0.041
1.528LysGln: 1.528 ± 0.031
2.405LysArg: 2.405 ± 0.041
2.22LysSer: 2.22 ± 0.037
2.173LysThr: 2.173 ± 0.036
2.1LysVal: 2.1 ± 0.037
0.518LysTrp: 0.518 ± 0.017
0.749LysTyr: 0.749 ± 0.019
0.0LysXaa: 0.0 ± 0.0
Leu
10.087LeuAla: 10.087 ± 0.085
0.969LeuCys: 0.969 ± 0.023
6.074LeuAsp: 6.074 ± 0.061
4.95LeuGlu: 4.95 ± 0.053
3.301LeuPhe: 3.301 ± 0.047
6.679LeuGly: 6.679 ± 0.063
1.892LeuHis: 1.892 ± 0.032
5.247LeuIle: 5.247 ± 0.053
3.167LeuLys: 3.167 ± 0.052
8.572LeuLeu: 8.572 ± 0.089
2.035LeuMet: 2.035 ± 0.038
3.161LeuAsn: 3.161 ± 0.053
5.305LeuPro: 5.305 ± 0.056
3.583LeuGln: 3.583 ± 0.046
6.217LeuArg: 6.217 ± 0.064
6.747LeuSer: 6.747 ± 0.055
5.82LeuThr: 5.82 ± 0.09
6.798LeuVal: 6.798 ± 0.055
1.146LeuTrp: 1.146 ± 0.029
1.895LeuTyr: 1.895 ± 0.03
0.0LeuXaa: 0.0 ± 0.0
Met
2.068MetAla: 2.068 ± 0.043
0.198MetCys: 0.198 ± 0.01
1.046MetAsp: 1.046 ± 0.022
0.958MetGlu: 0.958 ± 0.024
0.755MetPhe: 0.755 ± 0.02
1.447MetGly: 1.447 ± 0.032
0.463MetHis: 0.463 ± 0.014
1.462MetIle: 1.462 ± 0.031
1.007MetLys: 1.007 ± 0.022
2.296MetLeu: 2.296 ± 0.033
0.649MetMet: 0.649 ± 0.019
0.956MetAsn: 0.956 ± 0.022
1.393MetPro: 1.393 ± 0.029
0.909MetGln: 0.909 ± 0.024
1.533MetArg: 1.533 ± 0.03
1.654MetSer: 1.654 ± 0.032
1.63MetThr: 1.63 ± 0.029
1.486MetVal: 1.486 ± 0.03
0.228MetTrp: 0.228 ± 0.011
0.348MetTyr: 0.348 ± 0.013
0.0MetXaa: 0.0 ± 0.0
Asn
3.224AsnAla: 3.224 ± 0.057
0.323AsnCys: 0.323 ± 0.014
2.511AsnAsp: 2.511 ± 0.07
2.274AsnGlu: 2.274 ± 0.03
1.133AsnPhe: 1.133 ± 0.029
3.001AsnGly: 3.001 ± 0.084
0.83AsnHis: 0.83 ± 0.017
1.377AsnIle: 1.377 ± 0.029
0.725AsnLys: 0.725 ± 0.019
3.102AsnLeu: 3.102 ± 0.041
0.526AsnMet: 0.526 ± 0.014
1.194AsnAsn: 1.194 ± 0.049
2.175AsnPro: 2.175 ± 0.04
1.61AsnGln: 1.61 ± 0.026
2.449AsnArg: 2.449 ± 0.038
2.141AsnSer: 2.141 ± 0.056
1.765AsnThr: 1.765 ± 0.059
2.56AsnVal: 2.56 ± 0.051
0.494AsnTrp: 0.494 ± 0.015
0.82AsnTyr: 0.82 ± 0.021
0.0AsnXaa: 0.0 ± 0.0
Pro
4.844ProAla: 4.844 ± 0.06
0.365ProCys: 0.365 ± 0.016
3.546ProAsp: 3.546 ± 0.049
3.603ProGlu: 3.603 ± 0.051
1.787ProPhe: 1.787 ± 0.034
3.947ProGly: 3.947 ± 0.053
1.107ProHis: 1.107 ± 0.026
3.061ProIle: 3.061 ± 0.035
1.796ProLys: 1.796 ± 0.034
4.39ProLeu: 4.39 ± 0.051
1.276ProMet: 1.276 ± 0.023
2.032ProAsn: 2.032 ± 0.033
2.91ProPro: 2.91 ± 0.05
1.816ProGln: 1.816 ± 0.032
2.612ProArg: 2.612 ± 0.037
3.906ProSer: 3.906 ± 0.046
3.543ProThr: 3.543 ± 0.043
3.78ProVal: 3.78 ± 0.045
0.714ProTrp: 0.714 ± 0.022
1.031ProTyr: 1.031 ± 0.023
0.0ProXaa: 0.0 ± 0.0
Gln
3.828GlnAla: 3.828 ± 0.049
0.427GlnCys: 0.427 ± 0.014
1.873GlnAsp: 1.873 ± 0.031
1.8GlnGlu: 1.8 ± 0.033
1.559GlnPhe: 1.559 ± 0.029
2.368GlnGly: 2.368 ± 0.032
0.87GlnHis: 0.87 ± 0.02
2.339GlnIle: 2.339 ± 0.034
1.253GlnLys: 1.253 ± 0.027
3.953GlnLeu: 3.953 ± 0.048
0.919GlnMet: 0.919 ± 0.021
1.239GlnAsn: 1.239 ± 0.027
2.283GlnPro: 2.283 ± 0.033
1.774GlnGln: 1.774 ± 0.039
3.087GlnArg: 3.087 ± 0.046
3.2GlnSer: 3.2 ± 0.039
2.868GlnThr: 2.868 ± 0.041
2.613GlnVal: 2.613 ± 0.032
0.796GlnTrp: 0.796 ± 0.021
0.971GlnTyr: 0.971 ± 0.02
0.0GlnXaa: 0.0 ± 0.0
Arg
4.56ArgAla: 4.56 ± 0.056
0.841ArgCys: 0.841 ± 0.022
4.112ArgAsp: 4.112 ± 0.052
3.828ArgGlu: 3.828 ± 0.057
3.015ArgPhe: 3.015 ± 0.037
4.267ArgGly: 4.267 ± 0.046
1.537ArgHis: 1.537 ± 0.029
3.89ArgIle: 3.89 ± 0.051
2.186ArgLys: 2.186 ± 0.043
7.266ArgLeu: 7.266 ± 0.088
1.813ArgMet: 1.813 ± 0.036
2.082ArgAsn: 2.082 ± 0.031
3.192ArgPro: 3.192 ± 0.045
2.775ArgGln: 2.775 ± 0.043
5.336ArgArg: 5.336 ± 0.089
4.694ArgSer: 4.694 ± 0.057
3.393ArgThr: 3.393 ± 0.047
4.739ArgVal: 4.739 ± 0.052
1.304ArgTrp: 1.304 ± 0.027
1.881ArgTyr: 1.881 ± 0.028
0.0ArgXaa: 0.0 ± 0.0
Ser
5.833SerAla: 5.833 ± 0.055
0.604SerCys: 0.604 ± 0.02
4.687SerAsp: 4.687 ± 0.054
3.995SerGlu: 3.995 ± 0.047
2.521SerPhe: 2.521 ± 0.039
6.188SerGly: 6.188 ± 0.098
1.466SerHis: 1.466 ± 0.028
3.923SerIle: 3.923 ± 0.044
2.071SerLys: 2.071 ± 0.036
6.935SerLeu: 6.935 ± 0.062
1.653SerMet: 1.653 ± 0.031
2.401SerAsn: 2.401 ± 0.054
3.963SerPro: 3.963 ± 0.047
2.758SerGln: 2.758 ± 0.04
4.33SerArg: 4.33 ± 0.055
4.926SerSer: 4.926 ± 0.058
4.034SerThr: 4.034 ± 0.07
5.131SerVal: 5.131 ± 0.058
0.888SerTrp: 0.888 ± 0.023
1.377SerTyr: 1.377 ± 0.031
0.0SerXaa: 0.0 ± 0.0
Thr
5.576ThrAla: 5.576 ± 0.072
0.536ThrCys: 0.536 ± 0.018
3.831ThrAsp: 3.831 ± 0.071
3.128ThrGlu: 3.128 ± 0.037
2.306ThrPhe: 2.306 ± 0.059
4.989ThrGly: 4.989 ± 0.099
1.215ThrHis: 1.215 ± 0.022
3.838ThrIle: 3.838 ± 0.08
1.777ThrLys: 1.777 ± 0.031
5.904ThrLeu: 5.904 ± 0.089
1.256ThrMet: 1.256 ± 0.027
2.096ThrAsn: 2.096 ± 0.062
3.646ThrPro: 3.646 ± 0.045
2.102ThrGln: 2.102 ± 0.03
3.37ThrArg: 3.37 ± 0.043
3.988ThrSer: 3.988 ± 0.069
3.812ThrThr: 3.812 ± 0.088
4.353ThrVal: 4.353 ± 0.095
0.794ThrTrp: 0.794 ± 0.02
1.352ThrTyr: 1.352 ± 0.035
0.0ThrXaa: 0.0 ± 0.0
Val
7.335ValAla: 7.335 ± 0.059
0.871ValCys: 0.871 ± 0.029
5.062ValAsp: 5.062 ± 0.062
4.196ValGlu: 4.196 ± 0.049
2.572ValPhe: 2.572 ± 0.039
5.417ValGly: 5.417 ± 0.067
1.476ValHis: 1.476 ± 0.028
3.911ValIle: 3.911 ± 0.042
1.977ValLys: 1.977 ± 0.033
6.583ValLeu: 6.583 ± 0.063
1.595ValMet: 1.595 ± 0.031
2.323ValAsn: 2.323 ± 0.051
3.534ValPro: 3.534 ± 0.046
2.494ValGln: 2.494 ± 0.034
4.865ValArg: 4.865 ± 0.051
4.936ValSer: 4.936 ± 0.058
4.485ValThr: 4.485 ± 0.089
5.589ValVal: 5.589 ± 0.058
1.062ValTrp: 1.062 ± 0.024
1.57ValTyr: 1.57 ± 0.028
0.0ValXaa: 0.0 ± 0.0
Trp
1.046TrpAla: 1.046 ± 0.023
0.188TrpCys: 0.188 ± 0.01
0.79TrpAsp: 0.79 ± 0.017
0.65TrpGlu: 0.65 ± 0.017
0.597TrpPhe: 0.597 ± 0.017
0.858TrpGly: 0.858 ± 0.021
0.413TrpHis: 0.413 ± 0.015
0.941TrpIle: 0.941 ± 0.023
0.645TrpLys: 0.645 ± 0.02
1.645TrpLeu: 1.645 ± 0.035
0.47TrpMet: 0.47 ± 0.017
0.608TrpAsn: 0.608 ± 0.02
0.663TrpPro: 0.663 ± 0.02
0.761TrpGln: 0.761 ± 0.016
0.961TrpArg: 0.961 ± 0.019
1.009TrpSer: 1.009 ± 0.021
0.897TrpThr: 0.897 ± 0.022
0.948TrpVal: 0.948 ± 0.026
0.28TrpTrp: 0.28 ± 0.012
0.344TrpTyr: 0.344 ± 0.011
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.024TyrAla: 2.024 ± 0.032
0.28TyrCys: 0.28 ± 0.011
1.52TyrAsp: 1.52 ± 0.025
1.418TyrGlu: 1.418 ± 0.024
0.97TyrPhe: 0.97 ± 0.023
1.876TyrGly: 1.876 ± 0.029
0.619TyrHis: 0.619 ± 0.018
0.745TyrIle: 0.745 ± 0.018
0.518TyrLys: 0.518 ± 0.018
2.311TyrLeu: 2.311 ± 0.034
0.348TyrMet: 0.348 ± 0.013
0.683TyrAsn: 0.683 ± 0.023
1.161TyrPro: 1.161 ± 0.028
1.214TyrGln: 1.214 ± 0.021
2.029TyrArg: 2.029 ± 0.037
1.344TyrSer: 1.344 ± 0.028
1.107TyrThr: 1.107 ± 0.035
1.536TyrVal: 1.536 ± 0.024
0.384TyrTrp: 0.384 ± 0.012
0.677TyrTyr: 0.677 ± 0.021
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 6138 proteins (2488680 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski